# 2021 Orlando Open II – Singles

Jenson Brooksby was the defending champion but withdrew from the quarterfinals.
Christopher Eubanks won the title after defeating Nicolás Mejía 2–6, 7–6$^{(7–3)}$, 6–4 in the final.

## Seeds

* Yasutaka Uchiyama (first round)
* Jason Jung (first round)
* Jenson Brooksby (quarterfinals, withdrew)
* Paolo Lorenzi (first round)
* Emilio Gómez (quarterfinals)
* Ernesto Escobedo (first round)
* Guido Andreozzi (second round)
* Mitchell Krueger (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| | JC Aragone | 6 | 6$^1$ | 0 | | | | | |
| Q | Nicolás Mejía | 1 | 7$^7$ | 6 | | | | | |
| Q | Nicolás Mejía | 1 | 7$^7$ | 6 | Q | Nicolás Mejía | 6 | 6$^3$ | 4 |
| | | | | | | Christopher Eubanks | 2 | 7$^7$ | 6 |
| WC | Sam Riffice | 3 | 6$^3$ | | | Christopher Eubanks | 2 | 7$^7$ | 6 |
| | Christopher Eubanks | 6 | 7$^7$ | | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | Y Uchiyama | 5 | 2 | | | | | | | | | | | | | | |
| | JC Aragone | 7 | 6 | | | JC Aragone | 6 | 7 | | | | | | | | | |
| Q | TA Tirante | 6 | 6 | | Q | TA Tirante | 3 | 5 | | | | | | | | | |
| Q | S Kozlov | 3 | 1 | | | | | | | JC Aragone | 6 | 7 | | | | | |
| | C Harrison | 6 | 6 | | | | | | 5 | E Gómez | 4 | 5 | | | | | |
| | H Moriya | 0 | 2 | | | C Harrison | 3 | 3 | | | | | | | | | |
| WC | O Crawford | 6$^2$ | 7$^7$ | 3 | 5 | E Gómez | 6 | 6 | | | | | | | | | |
| 5 | E Gómez | 7$^7$ | 6$^4$ | 6 | | | | | | | | | | JC Aragone | 6 | 6$^1$ | 0 |
| 3 | J Brooksby | 7$^7$ | 6 | | | | | | | | | | Q | N Mejía | 1 | 7$^7$ | 6 |
| | D King | 6$^5$ | 3 | | 3 | J Brooksby | 6 | 6 | | | | | | | | | |
| | R Quiroz | 6$^4$ | 4 | | | J Kubler | 3 | 1 | | | | | | | | | |
| | J Kubler | 7$^7$ | 6 | | | | | | 3 | J Brooksby | | | | | | | |
| Q | N Mejía | 6 | 6 | | | | | | Q | N Mejía | w/o | | | | | | |
| | S Mukund | 4 | 1 | | Q | N Mejía | 7 | 6 | | | | | | | | | |
| Q | D Kelly | 6 | 4 | 5 | 7 | G Andreozzi | 5 | 3 | | | | | | | | | |
| 7 | G Andreozzi | 4 | 6 | 7 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | E Escobedo | 4 | 6$^4$ | | | | | | | | | | | | | |
| | T-S Kwiatkowski | 6 | 7$^7$ | | T-S Kwiatkowski | 6$^5$ | 6 | 2 | | | | | | | | |
| | U Blanch | 6 | 6 | | U Blanch | 7$^7$ | 3 | 6 | | | | | | | | |
| | K King | 4 | 4 | | | | | | | U Blanch | 1 | 5 | | | | |
| | G Oliveira | 2 | 2$^r$ | | | | | | WC | S Riffice | 6 | 7 | | | | |
| | R Cid Subervi | 6 | 4 | | R Cid Subervi | 2 | 2 | | | | | | | | | |
| WC | S Riffice | 6 | 6 | WC | S Riffice | 6 | 6 | | | | | | | | | |
| 4 | P Lorenzi | 2 | 4 | | | | | | | | | | WC | S Riffice | 3 | 6$^3$ |
| 8 | M Krueger | 6 | 7 | | | | | | | | | | | C Eubanks | 6 | 7$^7$ |
| | J Sock | 2 | 5 | 8 | M Krueger | 6$^5$ | 6$^3$ | | | | | | | | | |
| | C Eubanks | 6 | 6 | | C Eubanks | 7$^7$ | 7$^7$ | | | | | | | | | |
| | A Ritschard | 3 | 4 | | | | | | | C Eubanks | 6 | 7 | | | | |
| | P Polansky | 6 | 6 | | | | | | | N Jarry | 3 | 5 | | | | |
| WC | D Young | 2 | 2 | | P Polansky | 3 | 3 | | | | | | | | | |
| | N Jarry | 6 | 7 | | N Jarry | 6 | 6 | | | | | | | | | |
| 2 | J Jung | 4 | 5 | | | | | | | | | | | | | |