# 2021 Zagreb Ladies Open – Singles

Ana Konjuh was the defending champion but chose to compete in Madrid instead.
Anhelina Kalinina won the title, defeating Kamilla Rakhimova in the final, 6–1, 6–3.

## Seeds

* Elisabetta Cocciaretto (second round)
* Greet Minnen (first round)
* Katarzyna Kawa (first round)
* Kamilla Rakhimova (final)
* Kristína Kučová (quarterfinals)
* Kurumi Nara (first round)
* Barbara Haas (quarterfinals)
* Olga Danilović (withdrew)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| PR | Alexandra Dulgheru | 4 | 5 | | | | |
| 4 | Kamilla Rakhimova | 6 | 7 | | | | |
| 4 | Kamilla Rakhimova | 6 | 7 | 4 | Kamilla Rakhimova | 1 | 3 |
| | | | | | Anhelina Kalinina | 6 | 6 |
| | Anhelina Kalinina | 6 | 6 | | Anhelina Kalinina | 6 | 6 |
| Q | Jessica Pieri | 2 | 0 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | E Cocciaretto | 4 | 6 | 7$^{10}$ | | | | | | | | | | | | | | |
| | R Šramková | 6 | 3 | 6$^8$ | 1 | E Cocciaretto | 4 | 1 | | | | | | | | | | |
| PR | A Dulgheru | 6 | 6 | | PR | A Dulgheru | 6 | 6 | | | | | | | | | | |
| LL | F Arcidiacono | 0 | 1 | | | | | | | PR | A Dulgheru | 1 | 6 | 6 | | | | |
| PR | I Khromacheva | 4 | 6 | 4 | | | | | | 5 | K Kučová | 6 | 2 | 1 | | | | |
| | A Gasanova | 6 | 4 | 6 | | A Gasanova | 5 | 2 | | | | | | | | | | |
| WC | M Đaković | 1 | 4 | | 5 | K Kučová | 7 | 6 | | | | | | | | | | |
| 5 | K Kučová | 6 | 6 | | | | | | | | | | | | PR | A Dulgheru | 4 | 5 |
| 4 | K Rakhimova | 6 | 4 | 6 | | | | | | | | | | | 4 | K Rakhimova | 6 | 7 |
| | L Pattinama Kerkhove | 1 | 6 | 0 | 4 | K Rakhimova | 6 | 2 | 7 | | | | | | | | | |
| Q | T Mrdeža | 2 | 6 | 6 | Q | T Mrdeža | 4 | 6 | 5 | | | | | | | | | |
| Q | A Prisăcariu | 6 | 3 | 3 | | | | | | 4 | K Rakhimova | 6 | 4 | 6 | | | | |
| WC | J Fett | 6 | 6 | | | | | | | WC | J Fett | 3 | 6 | 4 | | | | |
| WC | L Bošković | 2 | 1 | | WC | J Fett | 6 | 6 | | | | | | | | | | |
| Q | RL Jani | 6 | 6 | | Q | RL Jani | 4 | 3 | | | | | | | | | | |
| LL | M Benoît | 1 | 2 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | K Nara | 4 | 3 | | | | | | | | | | | | | | | |
| WC | P Marčinko | 6 | 6 | | WC | P Marčinko | 1 | 2 | | | | | | | | | | |
| Q | J Niemeier | 6 | 7$^9$ | | Q | J Niemeier | 6 | 6 | | | | | | | | | | |
| Q | D Jakupović | 4 | 6$^7$ | | | | | | | Q | J Niemeier | 5 | 4 | | | | | |
| | A Kalinina | 6 | 6$^5$ | 6 | | | | | | | A Kalinina | 7 | 6 | | | | | |
| | M Bolkvadze | 3 | 7$^7$ | 2 | | A Kalinina | 6$^0$ | 6 | 6 | | | | | | | | | |
| JE | D Parry | 6 | 5 | 6 | JE | D Parry | 7$^7$ | 3 | 2 | | | | | | | | | |
| 3 | K Kawa | 4 | 7 | 4 | | | | | | | | | | | | A Kalinina | 6 | 6 |
| 7 | B Haas | 6$^5$ | 6 | 6 | | | | | | | | | | | Q | J Pieri | 2 | 0 |
| | C Bucșa | 7$^7$ | 1 | 2 | 7 | B Haas | 6 | 6 | | | | | | | | | | |
| Q | T Würth | 6 | 4 | 7$^7$ | Q | T Würth | 3 | 4 | | | | | | | | | | |
| Q | R Marino | 4 | 6 | 6$^4$ | | | | | | 7 | B Haas | 2 | 7 | 1 | | | | |
| Q | J Pieri | 2 | 6 | 6 | | | | | | Q | J Pieri | 6 | 5 | 6 | | | | |
| | M Di Giuseppe | 6 | 2 | 2 | Q | J Pieri | 4 | 7$^7$ | 6 | | | | | | | | | |
| | E-G Ruse | 6 | 6 | | | E-G Ruse | 6 | 6$^5$ | 3 | | | | | | | | | |
| 2 | G Minnen | 3 | 1 | | | | | | | | | | | | | | | |