# 2022 Santa Cruz Challenger II – Singles

Francisco Cerúndolo was the defending champion but chose not to defend his title.
Paul Jubb won the title after defeating Juan Pablo Varillas 6–3, 7–6$^{(7–5)}$ in the final.

## Seeds

* Hugo Dellien (withdrew)
* Pablo Cuevas (semifinals)
* Juan Pablo Varillas (final)
* Tomás Martín Etcheverry (withdrew)
* Tomás Barrios Vera (quarterfinals)
* Camilo Ugo Carabelli (withdrew)
* Facundo Mena (quarterfinals)
* Jesper de Jong (second round, retired)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Paul Jubb | 6 | 7 | | | | |
| LL | Daniel Dutra da Silva | 4 | 5 | | | | |
| LL | Daniel Dutra da Silva | 4 | 5 | | Paul Jubb | 6 | 7$^7$ |
| | | | | 3 | Juan Pablo Varillas | 3 | 6$^5$ |
| 3 | Juan Pablo Varillas | 6 | 6 | 3 | Juan Pablo Varillas | 3 | 6$^5$ |
| 2/WC | Pablo Cuevas | 2 | 4 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| Q | N Nakagawa | 2 | 4 | | | | | | | | | | | | | | |
| | P Jubb | 6 | 6 | | | P Jubb | 6 | 6 | | | | | | | | | |
| Q | JB Torres | 6 | 6 | | Q | JB Torres | 2 | 3 | | | | | | | | | |
| Q | Gilbert Klier Júnior | 3 | 4 | | | | | | | | P Jubb | 6 | 7$^7$ | | | | |
| | H Casanova | 6 | 7 | | | | | | | | H Casanova | 3 | 6$^4$ | | | | |
| Q | C Denolly | 4 | 5 | | | H Casanova | 4 | | | | | | | | | | |
| Q | Y Oliel | 6$^1$ | 3 | | 8 | J de Jong | 0$^r$ | | | | | | | | | | |
| 8 | J de Jong | 7$^7$ | 6 | | | | | | | | | | | | P Jubb | 6 | 7 |
| LL | D Dutra da Silva | 6 | 6 | | | | | | | | | | | LL | D Dutra da Silva | 4 | 5 |
| | G Melzer | 2 | 3 | | LL | D Dutra da Silva | 6 | 6 | | | | | | | | | |
| | A Collarini | 3 | 4 | | | M Pucinelli de Almeida | 4 | 4 | | | | | | | | | |
| | M Pucinelli de Almeida | 6 | 6 | | | | | | | LL | D Dutra da Silva | 6 | 6 | | | | |
| | G Lama | 5 | 2 | | | | | | | 5 | T Barrios Vera | 4 | 3 | | | | |
| | F Meligeni Alves | 7 | 6 | | | F Meligeni Alves | 6 | 3 | 4 | | | | | | | | |
| Alt | N Hardt | 3 | 6 | 1 | 5 | T Barrios Vera | 4 | 6 | 6 | | | | | | | | |
| 5 | T Barrios Vera | 6 | 3 | 6 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | F Mena | 7 | 6 | | | | | | | | | | | | | | | |
| | G Oliveira | 5 | 4 | | 7 | F Mena | 2 | 7$^7$ | 6 | | | | | | | | | |
| | N Moreno de Alboran | 3 | 1 | | | A Ritschard | 6 | 6$^5$ | 4 | | | | | | | | | |
| | A Ritschard | 6 | 6 | | | | | | | 7 | F Mena | 4 | 5 | | | | | |
| Alt | J Nikles | 6 | 6 | | | | | | | 3 | JP Varillas | 6 | 7 | | | | | |
| WC | JC Prado Ángelo | 2 | 4 | | Alt | J Nikles | 2 | 1 | | | | | | | | | | |
| | R Olivo | 2 | 2 | | 3 | JP Varillas | 6 | 6 | | | | | | | | | | |
| 3 | JP Varillas | 6 | 6 | | | | | | | | | | | | 3 | JP Varillas | 6 | 6 |
| LL | G Villanueva | 5 | 6$^4$ | | | | | | | | | | | | 2/WC | P Cuevas | 2 | 4 |
| | S Rodríguez Taverna | 7 | 7$^7$ | | | S Rodríguez Taverna | 6$^4$ | 4 | | | | | | | | | | |
| | GA Olivieri | 2 | 7$^7$ | 6 | | GA Olivieri | 7$^7$ | 6 | | | | | | | | | | |
| Q | N Barrientos | 6 | 6$^4$ | 2 | | | | | | | GA Olivieri | 6 | 1 | 2 | | | | |
| LL | Facundo Juárez | 0 | 6$^5$ | | | | | | | 2/WC | P Cuevas | 3 | 6 | 6 | | | | |
| | S Diez | 6 | 7$^7$ | | | S Diez | 4 | 1 | | | | | | | | | | |
| WC | M Dellien | 4 | 6 | 3 | 2/WC | P Cuevas | 6 | 6 | | | | | | | | | | |
| 2/WC | P Cuevas | 6 | 3 | 6 | | | | | | | | | | | | | | |