# 2022 Sanremo Challenger – Singles

This was the first edition of the tournament since it was discontinued in 2011.
Holger Rune won the title after defeating Francesco Passaro 6–1, 2–6, 6–4 in the final.

## Seeds

* Holger Rune (champion)
* Gianluca Mager (semifinals)
* Radu Albot (second round)
* Pierre-Hugues Herbert (first round)
* Hugo Grenier (first round)
* Flavio Cobolli (first round)
* Thomas Fabbiano (quarterfinals)
* Alexandre Müller (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Holger Rune | 6 | 6 | | | | | |
| | Andrea Arnaboldi | 4 | 1 | | | | | |
| | Andrea Arnaboldi | 4 | 1 | 1 | Holger Rune | 6 | 2 | 6 |
| | | | | Q | Francesco Passaro | 1 | 6 | 4 |
| Q | Francesco Passaro | 6 | 6 | Q | Francesco Passaro | 1 | 6 | 4 |
| 2 | Gianluca Mager | 1 | 1 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | H Rune | 6 | 7$^{14}$ | | | | | | | | | | | | | | | |
| | E Tiurnev | 3 | 6$^{12}$ | | 1 | H Rune | 6 | 6 | | | | | | | | | | |
| | G Zeppieri | 4 | 2 | | | N Fatić | 3 | 2 | | | | | | | | | | |
| | N Fatić | 6 | 6 | | | | | | | 1 | H Rune | 6 | 6 | | | | | |
| | G Blancaneaux | 3 | 0$^r$ | | | | | | | WC | M Gigante | 3 | 0 | | | | | |
| Q | M Martineau | 6 | 4 | | Q | M Martineau | 3 | 5 | | | | | | | | | | |
| WC | M Gigante | 2 | 6 | 6 | WC | M Gigante | 6 | 7 | | | | | | | | | | |
| 6 | F Cobolli | 6 | 4 | 3 | | | | | | | | | | | 1 | H Rune | 6 | 6 |
| 4 | P-H Herbert | 6 | 3 | 3 | | | | | | | | | | | | A Arnaboldi | 4 | 1 |
| | M Zekić | 4 | 6 | 6 | | M Zekić | 7 | 2 | 4 | | | | | | | | | |
| | R Haase | 5 | 6 | 2 | | A Vatutin | 5 | 6 | 6 | | | | | | | | | |
| | A Vatutin | 7 | 2 | 6 | | | | | | | A Vatutin | 2 | 6 | 6$^7$ | | | | |
| WC | M Arnaldi | 5 | 5 | | | | | | | | A Arnaboldi | 6 | 3 | 7$^9$ | | | | |
| | R Bonadio | 7 | 7 | | | R Bonadio | 6 | 2 | 3 | | | | | | | | | |
| | A Arnaboldi | 6 | 6 | | | A Arnaboldi | 4 | 6 | 6 | | | | | | | | | |
| 5 | H Grenier | 3 | 2 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | A Müller | 6 | 6 | | | | | | | | | | | | | | | |
| | L Miedler | 3 | 4 | | 8 | A Müller | 1 | 2 | | | | | | | | | | |
| | B Gojo | 4 | 2 | | Q | F Passaro | 6 | 6 | | | | | | | | | | |
| Q | F Passaro | 6 | 6 | | | | | | | Q | F Passaro | 4 | 6 | 6 | | | | |
| Q | M Valkusz | 6 | 6 | | | | | | | Q | M Valkusz | 6 | 3 | 2 | | | | |
| WC | M Donati | 1 | 2 | | Q | M Valkusz | 6 | 1 | 6 | | | | | | | | | |
| Q | K Sultanov | 2 | 6 | 1 | 3 | R Albot | 3 | 6 | 2 | | | | | | | | | |
| 3 | R Albot | 6 | 3 | 6 | | | | | | | | | | | Q | F Passaro | 6 | 6 |
| 7 | T Fabbiano | 7 | 1 | 6 | | | | | | | | | | | 2 | G Mager | 1 | 1 |
| | J Sels | 5 | 6 | 2 | 7 | T Fabbiano | 7 | 3 | 7 | | | | | | | | | |
| | V Sachko | 6 | 6 | | | V Sachko | 5 | 6 | 5 | | | | | | | | | |
| Q | Edoardo Lavagno | 3 | 4 | | | | | | | 7 | T Fabbiano | 4 | 3 | | | | | |
| Q | V Vacherot | 1 | 7$^7$ | 6$^2$ | | | | | | 2 | G Mager | 6 | 6 | | | | | |
| | E Karlovskiy | 6 | 6$^5$ | 7$^7$ | | E Karlovskiy | 1 | 4 | | | | | | | | | | |
| | F Forti | 2 | 4 | | 2 | G Mager | 6 | 6 | | | | | | | | | | |
| 2 | G Mager | 6 | 6 | | | | | | | | | | | | | | | |