# U.S. Route 385 in Texas

U.S. Route 385 (US 385) is a north-south U.S. highway that runs from Big Bend National Park in Texas to Deadwood, South Dakota. In Texas, the highway runs from Big Bend National Park to the Oklahoma state line, north of Dalhart. US 385 is part of the La Entrada al Pacifico trade corridor from Interstate 10 in Fort Stockton to Interstate 20 in Odessa.

## Route description

US 385 begins at Big Bend National Park near the Persimmon Gap Visitor Center. About 40 miles to the north, the highway intersects US 90 in the town of Marathon, sharing a short overlap with that highway. In Fort Stockton, US 385 begins an overlap with Interstate 10 and US 67. At I-10 exit 273, US 67/385 end their overlap with the interstate, running in a northeast direction. US 385 ends its overlap with US 67 in McCamey, running in a slight northwest direction. The highway intersects with Interstate 20, entering into the city of Odessa. US 385 runs through the city, leaving it just south of the northern intersection with Loop 338.
In Seminole, US 385 begins an overlap with US 62, with the two highways running through Seagraves together. US 62 leaves the highway in Brownfield, with US 385 running in a mostly north direction. The highway enters the town of Levelland, running along the western boundary of South Plains College; after intersecting with SH 114 US 385 leaves the town. In Littlefield, US 385 shares a short overlap with Loop 430 around the downtown area. North of Littlefield, the highway runs through mainly rural areas, passing through the towns of Springlake and Sunnyside. North of Dimmitt, US 385 begins running through the panhandle section of Texas and becomes less rural. North of Hereford, the highway becomes a rural route once again. From Vega to Channing US 385 makes a backwards c-shape, crossing the Canadian River in the process. US 385 runs through the Rita Blanca National Grassland, before entering into Oklahoma.

## Major intersections

| County | Location | mi | km | Destinations | Notes |
| Brewster | Big Bend | 0.0 | 0.0 | Main Park Road | Southern terminus of US 385 |
| Brewster | ​ | 0.8 | 1.3 | RM 2627 east – Black Gap Area, La Linda | |
| Brewster | Marathon | 39.7 | 63.9 | US 90 west – Marathon | South end of US 90 overlap |
| Brewster | ​ | 40.7 | 65.5 | US 90 east – Sanderson | North end of US 90 overlap |
| Pecos | Fort Stockton | 96.5 | 155.3 | Spur 194 west | |
| Pecos | Fort Stockton | 97.5 | 156.9 | I-10 BL west / US 285 north (Dickinson Boulevard) – Balmorhea | South end of BL I-10 / US 285 overlap |
| Pecos | Fort Stockton | 97.6 | 157.1 | FM 1053 north (Main Street) | |
| Pecos | Fort Stockton | 98.0 | 157.7 | US 285 south – Sanderson | North end of US 285 overlap |
| Pecos | Fort Stockton | 99.4 | 160.0 | I-10 west / US 67 south | North end of BL I-10 overlap; south end of I-10 / US 67 overlap; I-10 exit 261 |
| Pecos | ​ | 102.1 | 164.3 | Warnock Road | I-10 exit 264 |
| Pecos | ​ | 109.8 | 176.7 | University Road | I-10 exit 272 |
| Pecos | ​ | 110.9 | 178.5 | I-10 east – Ozona | North end of I-10 overlap; I-10 exit 273 |
| Pecos | Girvin | 131.9 | 212.3 | FM 11 – Imperial, Bakersfield | |
| Crane | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions |
| Upton | McCamey | 143.0 | 230.1 | US 67 north / FM 305 south – Rankin | North end of US 67 overlap; access to McCamey Hospital |
| Crane | Crane | 164.0 | 263.9 | SH 329 (6th Street) – Grandfalls, Rankin | |
| Crane | ​ | 173.1 | 278.6 | FM 1233 west | |
| Ector | ​ | 184.1 | 296.3 | FM 1787 east – Pleasant Farms | |
| Ector | ​ | 191.2 | 307.7 | Loop 338 | |
| Ector | ​ | 191.6 | 308.4 | FM 1882 north | |
| Ector | Odessa | 194.6 | 313.2 | I-20 / Pool Road – Monahans, Midland | I-20 exit 116 |
| Ector | Odessa | 196.0 | 315.4 | I-20 BL (2nd Street) | BL I-20 is former US 80; access to Medical Center Hospital |
| Ector | Odessa | 197.2 | 317.4 | Spur 450 west (Kermit Highway) – Kermit | |
| Ector | Odessa | 198.8 | 319.9 | SH 191 (42nd Street) | |
| Ector | ​ | 204.4 | 328.9 | Loop 338 | |
| Ector | ​ | 208.9 | 336.2 | SH 158 – Goldsmith, Gardendale | Interchange |
| Andrews | Andrews | 229.6 | 369.5 | Loop 1910 (South Mustang Drive) to SH 115 / SH 176 | Access to Permian Regional Medical Center |
| Andrews | Andrews | 230.5 | 371.0 | SH 115 / SH 176 (Broadway Street) – Kermit, Big Spring | |
| Andrews | ​ | 233.0 | 375.0 | Loop 1910 | |
| Andrews | ​ | 238.4 | 383.7 | FM 1967 west – Frankel City | |
| Gaines | ​ | 249.4 | 401.4 | FM 2885 north | |
| Gaines | ​ | 257.3 | 414.1 | FM 1788 south | |
| Gaines | Seminole | 258.4 | 415.9 | FM 181 south (South Avenue G) to US 62 / US 180 / SH 214 | |
| Gaines | Seminole | 258.9 | 416.7 | US 62 west / US 180 to SH 214 | South end of US 62 overlap; access to Seminole Hospital |
| Gaines | Seagraves | 276.4 | 444.8 | SH 83 – Denver City, Welch | |
| Terry | Wellman | 286.9 | 461.7 | FM 213 / FM 303 south | South end of FM 303 overlap |
| Terry | ​ | 291.0 | 468.3 | FM 303 north | North end of FM 303 overlap |
| Terry | Brownfield | 298.0 | 479.6 | SH 137 north / FM 403 south – Levelland | South end of SH 137 overlap |
| Terry | Brownfield | 298.2 | 479.9 | SH 137 south – Lamesa | North end of SH 137 overlap |
| Terry | Brownfield | 299.6 | 482.2 | US 82 west / US 380 west (Main Street) – Plains | South end of US 82/380 overlap |
| Terry | Brownfield | 299.8 | 482.5 | US 380 east (Tahoka Highway) – Terry County Airport | North end of US 380 overlap |
| Terry | Brownfield | 300.6 | 483.8 | US 62 east / US 82 east – Lubbock | North end of US 62/82 overlap |
| Terry | ​ | 303.0 | 487.6 | SH 137 south – Lamesa | |
| Terry | ​ | 306.3 | 492.9 | FM 2196 west | |
| Terry | ​ | 310.5 | 499.7 | FM 211 | |
| Terry | ​ | 314.5 | 506.1 | FM 3261 east – Lockettville | |
| Hockley | ​ | 316.7 | 509.7 | FM 41 – Ropesville | |
| Hockley | ​ | 320.2 | 515.3 | FM 301 west – Sundown | |
| Hockley | ​ | 323.5 | 520.6 | FM 1585 | |
| Hockley | Levelland | 328.4 | 528.5 | FM 300 (Avenue H) | |
| Hockley | Levelland | 329.8 | 530.8 | Bus. SH 114 west (Houston Street) | South end of Bus. SH 114 overlap |
| Hockley | Levelland | 330.2 | 531.4 | SH 114 – Morton, Lubbock | North end of Bus. SH 114 overlap |
| Hockley | ​ | 334.9 | 539.0 | FM 2306 west | |
| Hockley | ​ | 336.1 | 540.9 | FM 1294 east – Shallowater | |
| Hockley | ​ | 343.9 | 553.5 | FM 597 west | South end of FM 597 overlap |
| Hockley | ​ | 345.0 | 555.2 | FM 597 east – Anton | North end of FM 597 overlap |
| Lamb | Littlefield | 352.1 | 566.7 | US 84 – Muleshoe, Lubbock | Interchange; access to Lamb Healthcare Center |
| Lamb | Littlefield | 353.1 | 568.3 | FM 54 (Waylon Jennings Boulevard) | |
| Lamb | Littlefield | 353.5 | 568.9 | Loop 430 east – Lubbock | South end of Loop 430 overlap |
| Lamb | Littlefield | 353.6 | 569.1 | Loop 430 west | North end of Loop 430 overlap |
| Lamb | ​ | 356.9 | 574.4 | FM 2197 east | |
| Lamb | ​ | 359.7 | 578.9 | FM 37 – Amherst | |
| Lamb | Springlake | 375.1 | 603.7 | US 70 – Muleshoe, Plainview | |
| Lamb | ​ | 377.1 | 606.9 | FM 2901 west | |
| Castro | ​ | 385.3 | 620.1 | FM 145 – Lazbuddie, Hart | |
| Castro | ​ | 388.4 | 625.1 | FM 1524 west – Flagg | |
| Castro | Dimmitt | 396.2 | 637.6 | SH 194 east – Plainview | |
| Castro | Dimmitt | 396.5 | 638.1 | FM 3215 west | |
| Castro | Dimmitt | 397.4 | 639.6 | SH 86 | |
| Castro | Dimmitt | 397.7 | 640.0 | FM 2392 west | Access to Plains Memorial Hospital |
| Castro | ​ | 403.9 | 650.0 | FM 2397 – Easter | |
| Deaf Smith | ​ | 411.1 | 661.6 | FM 2943 north to US 60 east – Canyon | |
| Deaf Smith | ​ | 415.5 | 668.7 | FM 1055 south | |
| Deaf Smith | Hereford | 417.5 | 671.9 | US 60 (First Street) – Friona, Canyon | |
| Deaf Smith | Hereford | 418.2 | 673.0 | FM 1058 west (West Park Avenue) / Spur 211 east (East Park Avenue) – Grady, Canyon | |
| Deaf Smith | ​ | 429.3 | 690.9 | FM 1057 south / FM 1062 east – Canyon | |
| Deaf Smith | ​ | 432.4 | 695.9 | FM 1412 west – Walcott | |
| Deaf Smith | ​ | 437.4 | 703.9 | FM 2587 | |
| Oldham | ​ | 447.1 | 719.5 | I-40 | I-40 exit 36 |
| Oldham | Vega | 447.6 | 720.3 | I-40 BL (Vega Boulevard) – Adrian, Wildorado | Former US 66 |
| Oldham | ​ | 469.3 | 755.3 | RM 1061 south – Amarillo | |
| Oldham | ​ | 471.5 | 758.8 | Spur 233 east – Boys Ranch | |
| Hartley | Channing | 483.1 | 777.5 | SH 354 east / FM 767 west – Nara Visa, Four Way | |
| Hartley | ​ | 486.6 | 783.1 | FM 722 east – Dumas | |
| Hartley | Hartley | 497.0 | 799.8 | US 87 south – Dumas | Interchange; south end of US 87 overlap |
| Hartley | Hartley | 498.1 | 801.6 | FM 998 north / FM 807 north | |
| Dallam | Dalhart | 509.7 | 820.3 | FM 281 – Etter | |
| Dallam | Dalhart | 512.0 | 824.0 | Bus. US 87 north (7th Street) / Tennessee Avenue | |
| Dallam | Dalhart | 512.5 | 824.8 | US 54 – Tucumcari, Stratford | Access to Dalhart Municipal Airport |
| Dallam | Dalhart | 512.7 | 825.1 | US 87 north – Clayton | North end of US 87 overlap |
| Dallam | Dalhart | 513.8 | 826.9 | Spur 17 west / Truck Line Road | |
| Dallam | ​ | 540.1 | 869.2 | FM 296 west – Texline | |
| Dallam | ​ | 543.3 | 874.4 | US 385 north – Boise City | Continuation into Oklahoma |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus ||||||