# 2021–22 Coupe de France preliminary rounds, Auvergne-Rhône-Alpes

The 2021–22 Coupe de France preliminary rounds, Auvergne-Rhône-Alpes was the qualifying competition to decide which teams from the leagues of the Auvergne-Rhône-Alpes region of France took part in the main competition from the seventh round.
A total of nineteen teams qualified from the Auvergne-Rhône-Alpes preliminary rounds. In 2020–21, GFA Rumilly-Vallières progressed furthest in the main competition, becoming the first fourth tier side to reach the semi-final by beating Toulouse in the quarter-finals, before losing to Monaco.

## Draws and fixtures

On 10 August 2021, the league announced that a record 947 clubs had entered the competition from the region. The draw for the first round, featuring 836 teams from the district leagues and Régional 3, was made on 2 August 2021. Nine clubs in scope were exempted to the second round. The second round draw was published on 23 August 2021, with the exempted clubs and clubs from Régional 2 entering. The third round draw took place on 8 September 2021, and saw the Régional 1 and Championnat National 3 teams entering. The fourth round draw took place on 22 September 2021, and saw the Championnat National 2 teams entering. The fifth round draw, which saw the Championnat National teams entering, was made on 6 October 2021. The sixth round draw was made on 21 October 2021.

### First round

These matches were played on 28 and 29 August 2021.
First round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | FC Est Allier (11) | 2–5 | SC Gannat (9) |
| 2. | SC Ygrandais (11) | 0–8 | Stade Saint-Yorre (9) |
| 3. | AS Néris (12) | 0–4 | US Abrest (11) |
| 4. | CS Targetois (13) | 0–1 | FC Creuzier-le-Neuf (12) |
| 5. | AS Neuilly-le-Réal (11) | 1–1 (5–4 p) | CS Vaux-Estivareilles (11) |
| 6. | Espoir Molinetois (11) | 3–0 | AS Toulonnaise (10) |
| 7. | US Vallon (10) | 0–0 (6–5 p) | US Lignerolles-Lavault Sainte-Anne Prémilhat (8) |
| 8. | AS Val de Sioule (10) | 0–4 | AS Louchy (8) |
| 9. | US Varennes-sur-Tèche (10) | 0–3 | Bézenet-Doyet Foot (8) |
| 10. | FC Souvigny (10) | 3–2 | SC Avermes (8) |
| 11. | AS Gennetinoise (10) | 2–2 (5–6 p) | AS Varennes-sur-Allier (8) |
| 12. | Montluçon FC (11) | 1–2 | US Vendat (8) |
| 13. | Jaligny Vaumas Foot (10) | 2–3 | AC Creuzier-le-Vieux (8) |
| 14. | US Bien-Assis (11) | 3–2 | AS Tronget (10) |
| 15. | ES Montagne Bourbonnaise (11) | 3–0 | AS Sanssat (12) |
| 16. | Ballon Beaulonnais (10) | 0–4 | AS Dompierroise (9) |
| 17. | US Trezelles (10) | 2–1 | ES Vernetoise (9) |
| 18. | FC Haut d'Allier (10) | 2–1 | US Marcillat-Pionsat (10) |
| 19. | CS Chantelle (11) | 0–4 | US Chevagnes (11) |
| 20. | US Toque Huriel (11) | 3–3 (3–0 p) | OC Monetay-sur-Allier (11) |
| 21. | US Saint-Victor-Malescours (11) | 0–0 (3–4 p) | Magnet/Seuillet/Saint-Gérand-le-Puy Foot (11) |
| 22. | ES Saint-Étienne-de-Vicq/Bost (12) | 0–1 | FC Billy-Crechy (10) |
| 23. | US Malicorne (11) | 0–3 | Étoile Moulins Yzeure (9) |
| 24. | FR Pouzy-Mésangy (11) | 0–7 | Bourbon Sportif (9) |
| 25. | AS Rongères (11) | 0–1 | AL Quinssaines (10) |
| 26. | US Bussetoise (12) | 0–7 | Commentry FC (9) |
| 27. | US Coeur Allier (12) | 4–3 | Médiéval Club Montluçonnais (9) |
| 28. | CS Thielois (12) | 2–1 | Vigilante Garnat Saint-Martin (9) |
| 29. | AS Saint-Loup (12) | 2–1 | CS Cosne d'Allier (9) |
| 30. | Entente Pierrefitte/Saligny Foot (11) | 2–2 (7–8 p) | JS Neuvy (9) |
| 31. | AF Archignat-Treignat (12) | 0–2 | US Saulcet-Le Theil (11) |
| 32. | Entente Lurcy-Lévis/Cérilly (10) | 0–1 | US Biachette Désertines (10) |
| 33. | AS Chassenard Luneau (11) | 1–1 (6–5 p) | CS Bessay (9) |
| 34. | AS Boucetoise (10) | 1–2 | AC Franco-Algérienne (10) |
| 35. | Saint-Georges SL (11) | 2–0 | FC Artense (9) |
| 36. | ES Margeride (11) | 0–2 | FC Moussages (9) |
| 37. | AS Chaudes-Aigues (11) | 0–0 (3–4 p) | Carladez-Goul Sportif (9) |
| 38. | US Cère et Landes (10) | 1–2 | FC Junhac-Montsalvy (10) |
| 39. | AS Pleaux-Rilhac-Barriac (10) | 1–2 | AS Yolet (9) |
| 40. | US La Chapelle-Laurent (10) | 5–2 | Cère FC Vic/Polminhac (10) |
| 41. | FC Albepierre-Bredons (12) | 0–6 | FC des Quatre Vallées (9) |
| 42. | AS Neussargues (12) | 0–5 | ES Pierrefortaise (8) |
| 43. | ES Vebret-Ydes (11) | 2–2 (8–7 p) | CS Arpajonnais (8) |
| 44. | US Haut Célé (11) | 0–3 | Parlan-Le Rouget FC (8) |
| 45. | US Besse (11) | 0–2 | Sud Cantal Foot (8) |
| 46. | Jordanne FC (11) | 2–3 | ES Riomois-Condat (9) |
| 47. | Aspre FC Fontanges (13) | 2–1 | FC Minier (10) |
| 48. | US Giou de Mamou (13) | 0–5 | ES Saint-Mamet (9) |
| 49. | AS Naucelles (12) | 1–6 | CS Vézac (9) |
| 50. | AS Trizac (12) | 0–4 | AS Espinat (9) |
| 51. | FC Hauts de Cère (12) | 0–5 | AS Sansacoise (8) |
| 52. | US Loupiac Saint-Christophe (12) | 0–3 | AS Belbexoise (9) |
| 53. | AS Saint-Poncy (12) | 0–3 | US Murat (8) |
| 54. | ES Roannaise (12) | 0–8 | US Crandelles (9) |
| 55. | FC Paulhaguet (10) | 0–3 | FC Massiac-Molompize-Blesle (10) |
| 56. | US Vals Le Puy (9) | 2–0 | AS Saint-Didier-Saint-Just (8) |
| 57. | FC Tence (10) | 2–3 | FC Saint-Germain-Laprade (10) |
| 58. | AS Mazet-Chambon (11) | 0–1 | AS Grazac-Lapte (9) |
| 59. | AS Saint-Pierre-Eynac (10) | 0–4 | Seauve Sports (8) |
| 60. | CO Coubon (10) | 1–6 | Vigilante Saint-Pal-de-Mons (10) |
| 61. | US Bassoise (10) | 2–2 (2–4 p) | Olympic Saint-Julien-Chapteuil (8) |
| 62. | US Landos (9) | 2–3 | US Fontannoise (8) |
| 63. | AS Saugues (11) | 0–2 | AS Laussonne (9) |
| 64. | Aiguilhe FC (11) | 0–3 | FC Dunières (8) |
| 65. | AS Ally-Mercoeur (11) | 3–5 | AS Saint-Vidal (10) |
| 66. | FC Arzon (10) | 3–1 | US Arsac-en-Velay (9) |
| 67. | FC Vézézoux (10) | 1–4 | AS Chadrac (8) |
| 68. | US Montfaucon Montregard Raucoules (10) | 0–0 (4–2 p) | Sauveteurs Brivois (8) |
| 69. | Olympique Malrevers (13) | 1–11 | FC Aurec (10) |
| 70. | AS Riotord (12) | 0–5 | FJEP Freycenets Saint-Jeures (10) |
| 71. | AA Saint-Front (13) | 0–4 | AS Villettoise (9) |
| 72. | AS Saint-Pal-de-Chalencon (12) | 0–7 | US Bains-Saint-Christophe (9) |
| 73. | AS Pertuis (11) | 2–2 (4–2 p) | Solignac-Cussac FC (9) |
| 74. | FC Venteuges (12) | 0–6 | AS Cheminots Langeac (9) |
| 75. | AS Haute-Dordogne (10) | 1–3 | FF Chappes (11) |
| 76. | ES Champeyroux-Surat-Les Martres (11) | 0–4 | US Chapdes-Beaufort (10) |
| 77. | ES Couze Pavin (11) | 4–2 | RS Luzillat-Charnat-Vinzelles (10) |
| 78. | Pérignat FC (11) | 1–3 | US Limons (10) |
| 79. | AS Roche-Blanche FC (11) | 3–1 | RC Saint-Clément-de-Régnat (10) |
| 80. | AS Portugais Riom (11) | 1–3 | US Gervasienne (10) |
| 81. | ACS Cappadoce (11) | 2–0 | AL Glaine-Montaigut (10) |
| 82. | FC Mezel (11) | 0–2 | CS Pont-de-Dore (10) |
| 83. | US Messeix Bourg-Lastic (11) | 2–1 | FC Nord Combraille (10) |
| 84. | FC Sayat Argnat (11) | 3–2 | RAS Beauregard l'Évêque (10) |
| 85. | FC Bromont-Lamothe/Montfermy (11) | 2–1 | Durolle Foot (10) |
| 86. | ES Volcans Malauzat (11) | 1–1 (4–5 p) | CS Saint-Bonnet-près-Riom (10) |
| 87. | CO Veyre-Monton (10) | 1–2 | SC Billom (9) |
| 88. | FC Plauzat-Champeix (10) | 0–3 | US Bassin Minier (9) |
| 89. | Haute Combraille Foot (11) | 0–14 | FC Nord Limagne (9) |
| 90. | FC Saint-Julien-de-Coppel (10) | 1–2 | AS Job (9) |
| 91. | US Val de Couze Chambon (10) | 0–1 | FC Sauxillanges Saint-Babel Brenat (9) |
| 92. | US Courpière (9) | 1–6 | Espérance Ceyratois Football (8) |
| 93. | FC Aubierois (9) | 0–2 | Dômes-Sancy Foot (8) |
| 94. | Clermont Ouvoimoja (10) | 4–3 | US Ennezat (9) |
| 95. | FC Martres-Lussat (9) | 2–1 | US Maringues (8) |
| 96. | ÉS Saint-Rémy-sur-Durolle (10) | 0–7 | AS Saint-Genès-Champanelle (8) |
| 97. | AS Romagnat (9) | 1–2 | US Saint-Beauzire (8) |
| 98. | ES Saint-Germinoise (8) | 0–2 | AS Enval-Marsat (8) |
| 99. | AS Orcines (9) | 0–4 | EFC Saint-Amant-Tallende (8) |
| 100. | US Beauregard-Vendon (12) | 4–0 | US Menat-Neuf-Eglise (12) |
| 101. | AS Livradois Sud (9) | 2–2 (2–4 p) | UJ Clermontoise (8) |
| 102. | CS Saint-Anthème (12) | 1–4 | AS Moissat (10) |
| 103. | Clermont Outre-Mer (10) | 1–0 | US Orcet (9) |
| 104. | US Tours-sur-Meymont (12) | 2–4 | FC Lezoux (9) |
| 105. | FC Blanzat (9) | 1–2 | FC Vertaizon (8) |
| 106. | ALS Besse Egliseneuve (9) | 0–6 | US Les Martres-de-Veyre (8) |
| 107. | Ecureuils Franc Rosier (9) | 5–0 | US Saint-Georges / Les Ancizes (8) |
| 108. | Clermont Métropole FC (9) | 3–5 | US Vic-le-Comte (8) |
| 109. | Aulnat Sportif (12) | 3–0 | AS Royat (10) |
| 110. | Entente Charblot (11) | 1–5 | US Gerzat (9) |
| 111. | US Combronde (12) | 3–4 | FC Mirefleurs (10) |
| 112. | FC Paslières-Noalhat (12) | 1–3 | AS Cunlhat (11) |
| 113. | RC Charbonnières-Paugnat (10) | 3–3 (4–2 p) | JS Saint-Priest-des-Champs (9) |
| 114. | FC Augerollois (13) | 0–0 (2–3 p) | US Ménétrol (12) |
| 115. | AS Sugères (12) | 0–2 | AS Cellule (9) |
| 116. | AS Pontgibaud (13) | 0–3 | AS Saint-Ours (10) |
| 117. | US Saint-Sylvestre-Pragoulin (13) | 1–4 | Saint-Amant et Tallende SC (12) |
| 118. | JS Bresse Dombes (12) | 1–6 | AS Hautecourt-Romanèche (11) |
| 119. | Olympique Saint-Denis-lès-Bourg (11) | 1–5 | Olympique Sud Revermont 01 (10) |
| 120. | FC Nurieux-Volognat (12) | 0–4 | ES Revermontoise (10) |
| 121. | CSJ Châtillonnaise (11) | 0–2 | FC Côtière-Luenaz (10) |
| 122. | Côtière Meximieux Villieu (12) | 2–2 (5–4 p) | US Izernore (10) |
| 123. | SC Mille Étangs (12) | 0–1 | FC Saint-Maurice-de-Gourdans (11) |
| 124. | FC Veyle-Vieux-Jonc (12) | 1–1 (7–8 p) | ES Val de Saône (10) |
| 125. | FC Dombes (10) | 2–0 | ISN FC Chaniens (13) |
| 126. | CS Valromey (13) | 1–4 | Entente Bas Bugey Rhône (11) |
| 127. | FC Priay (12) | 1–2 | FC Montluel (13) |
| 128. | FC Mas-Rillier (12) | 0–3 | AS Portugaise Vaulx-en-Velin (10) |
| 129. | Concordia FC Bellegarde (10) | 1–2 | US Arbent Marchon (8) |
| 130. | AS Bâgé-le-Châtel (10) | 1–2 | FC Bressans (8) |
| 131. | US Replonges (10) | 0–3 | FC Veyle Sâone (8) |
| 132. | FC Curtafond-Confrançon-Saint-Martin-Saint-Didier (10) | 3–1 | Plaine Revermont Foot (9) |
| 133. | Bourg Sud (9) | 4–1 | AS Saint-Laurentin (10) |
| 134. | Olympique Rives de l'Ain-Pays du Cerdon (9) | 1–4 | CS Viriat (8) |
| 135. | Saint-Denis-Ambutrix FC (10) | 0–2 | CS Belley (9) |
| 136. | Bresse Foot 01 (10) | 0–1 | FC Plaine Tonique (9) |
| 137. | US Veyziat (11) | 3–6 | Ambérieu FC (9) |
| 138. | AS Attignat (10) | 2–1 | ES Foissiat-Étrez (8) |
| 139. | FC Artemare (13) | 0–3 | FC Saint-Vulbas Plaine de l'Ain (10) |
| 140. | CO Plateau (12) | 2–4 | Entente Saint-Martin-du-Frêne/Maillat/Combe du Val (11) |
| 141. | FO Leymentais (13) | 1–2 | Olympique Buyatin (11) |
| 142. | AS Chaveyriat-Chanoz (11) | 2–2 (2–3 p) | FC Manziat (10) |
| 143. | FC Injoux-Génissiat (12) | 0–3 | Valserine FC (11) |
| 144. | Association des Portugais d'Oyonnax (12) | 1–6 | AS Montréal-la-Cluse (9) |
| 145. | JS Bettant (13) | 0–5 | US Vaux-en-Bugey (12) |
| 146. | AS Travailleurs Turcs Oyonnax (11) | 6–2 | ES Ambronay-Saint-Jean-le-Vieux (10) |
| 147. | US Culoz Grand Colombier (10) | 0–3 | Oyonnax Plastics Vallée FC (8) |
| 148. | FC Dombes-Bresse (9) | 1–1 (4–2 p) | Olympique Belleroche Villefranche (8) |
| 149. | Jassans-Frans Foot (9) | 3–3 (3–4 p) | Belleville Football Beaujolais (8) |
| 150. | FO Bourg-en-Bresse (9) | 1–1 (1–4 p) | Caluire SC (8) |
| 151. | Foot Trois Rivières (11) | 2–3 | AS Genay (11) |
| 152. | Chazay FC (10) | 0–3 | SC Portes de l'Ain (9) |
| 153. | Fareins Saône Vallée Foot (10) | 0–3 | ÉS Liergues (9) |
| 154. | FC Serrières-Villebois (11) | 1–4 | AS Diémoz (10) |
| 155. | US Dombes-Chalamont (11) | 1–1 (4–5 p) | FC Rive Droite (10) |
| 156. | CS Chevroux (11) | 1–5 | Beaujolais Football (10) |
| 157. | FC Reneins Vauxonne (11) | 8–0 | FC Bresse Nord (10) |
| 158. | AS Saint-Étienne-sur-Chalaronne (12) | 5–0 | AS Limas (11) |
| 159. | FC Denicé Arnas (11) | 1–0 | FC Bord de Veyle (11) |
| 160. | AS Grièges Pont de Veyle (12) | 3–0 | RC Béligny (11) |
| 161. | US Formans (12) | 3–0 | ES Cormoranche (11) |
| 162. | AS Guéreins-Genouilleux (11) | 1–1 (3–4 p) | ASA Clochemerle (11) |
| 163. | Le Grand-Lemps/Colombe/Apprieu Foot 38 (12) | 2–4 | Beaucroissant FC (11) |
| 164. | Moirans FC (12) | 3–0 | US Montgasconnaise (11) |
| 165. | Vourey Sports (13) | 3–2 | FOC Froges (12) |
| 166. | CA Goncelin (13) | 0–6 | AS Fontaine (12) |
| 167. | US Abbaye (13) | 3–0 | Deux Rochers FC (11) |
| 168. | AS Cessieu (12) | 2–2 (2–4 p) | FC Virieu-Valondras (11) |
| 169. | FC Bourg-d'Oisans (12) | 1–2 | UO Portugal Saint-Martin-d'Hères (10) |
| 170. | FC Sud Isère (10) | 1–1 (7–8 p) | FC Vallée de la Gresse (8) |
| 171. | CS Voreppe (10) | 2–2 (7–6 p) | AJA Villeneuve (9) |
| 172. | AS Grésivaudan (11) | 1–1 (4–3 p) | ASJF Domène (10) |
| 173. | FC Canton de Vinay (12) | 1–3 | Rives SF (10) |
| 174. | ASF Portugais (11) | 7–0 | FC Bilieu (11) |
| 175. | FC Vallée Bleue (12) | 4–5 | Olympique Les Avenières (10) |
| 176. | FC Saint-Martin-d'Uriage (12) | 2–4 | JS Saint-Georgeoise (11) |
| 177. | US Beauvoir-Royas (11) | 0–2 | Isle d'Abeau FC (10) |
| 178. | US Cassolards Passageois (12) | 2–1 | ASCOL Foot 38 (11) |
| 179. | CF Estrablin (9) | 0–3 | AS Bron Grand Lyon (8) |
| 180. | US Creys-Morestel (10) | 1–5 | FC Colombier-Satolas (9) |
| 181. | US La Murette (9) | 3–3 (3–5 p) | FC Chaponnay-Marennes (8) |
| 182. | JS Cellieu (10) | 4–2 | FC Grigny (9) |
| 183. | Ménival FC (9) | 1–1 (5–4 p) | FC Val Lyonnais (8) |
| 184. | AS Toussieu (11) | 3–0 | AS Algerienne Villeurbanne (8) |
| 185. | FC Point du Jour (10) | 1–2 | FC Pays de l'Arbresle (9) |
| 186. | Rhône Sud FC (11) | 0–2 | CS Meginand (9) |
| 187. | US Vaulx-en-Velin (11) | 1–2 | Feyzin Club Belle Étoile (8) |
| 188. | AS Bellecour-Perrache (8) | 13–1 | FC Saint-Fons (11) |
| 189. | JS Irigny (9) | 0–3 | US Meyzieu (8) |
| 190. | SC Maccabi Lyon (11) | 1–7 | UGA Lyon-Décines (9) |
| 191. | AS Buers Villeurbanne (11) | 4–4 (2–4 p) | AS Villeurbanne Éveil Lyonnais (9) |
| 192. | US Des Monts (11) | 0–2 | ASC Générale Routière Maïa Sonnier (11) |
| 193. | FC Sud Ouest 69 (10) | 1–1 (1–3 p) | ES Genas Azieu (9) |
| 194. | ES Saint-Priest (10) | 3–1 | Olympique Rillieux (9) |
| 195. | ES Gleizé (11) | 1–1 (6–5 p) | Savigny FC (10) |
| 196. | USC Lyon Vaise (10) | 1–7 | ACS Mayotte du Rhône (11) |
| 197. | USM Pierre-Bénite (10) | 0–2 | AS Saint-Martin-en-Haut (9) |
| 198. | CO Saint-Fons (9) | 1–1 (5–4 p) | AS Craponne (8) |
| 199. | AS Quatre Vents Trèves (13) | 2–4 | US Montanay (11) |
| 200. | FC Meys-Grézieu (9) | 2–2 (3–4 p) | US Millery-Vourles (8) |
| 201. | FC Sourcieux-les-Mines (11) | 3–2 | FC Lamure Poule (10) |
| 202. | FC La Giraudière (11) | 1–1 (8–7 p) | ASM Saint-Pierre-la-Palud (10) |
| 203. | FC Sévenne (9) | 5–0 | Mions FC (8) |
| 204. | FC Corbas (9) | 0–5 | Sporting Nord-Isère (8) |
| 205. | FC Antillais Villeurbanne (13) | 2–1 | FC Franchevillois (11) |
| 206. | Association Chandieu-Heyrieux (9) | 3–1 | CS Verpillière (8) |
| 207. | JSO Givors (10) | 2–1 | US Est Lyonnais (9) |
| 208. | AS Écully (12) | 0–8 | FC Fontaines-sur-Saône (10) |
| 209. | Latino AFC Lyon (12) | 1–1 (3–2 p) | Éveil de Lyon (10) |
| 210. | US Loire-Saint-Romain (10) | 6–3 | AS Locataires de Bans FC (12) |
| 211. | US Villette-d'Anthon-Janneyrais (13) | 2–2 (5–4 p) | Muroise Foot (11) |
| 212. | SC Revolée (13) | 4–3 | FC Ternay (12) |
| 213. | ES Frontonas-Chamagnieu (11) | 1–2 | Saint-Alban Sportif (10) |
| 214. | FC Bully (12) | 0–2 | AS Saint-Forgeux (10) |
| 215. | Lyon Croix Rousse Football (11) | 3–0 | ES Charly Foot (10) |
| 216. | CS Vaulxois (11) | 0–5 | FC Croix Roussien (10) |
| 217. | AS Sornins Réunis (12) | 3–0 | USF Tarare (11) |
| 218. | Chambost-Allières-Saint-Just-d'Avray (12) | 6–2 | FC Saint-Romain-de-Popey (10) |
| 219. | CS Ozon (11) | 4–0 | AS Manissieux (10) |
| 220. | FC Franc Lyonnais (11) | 1–3 | CAS Cheminots Oullins Lyon (10) |
| 221. | US Côteaux Lyonnais (11) | 2–1 | FC Pontcharra-Saint-Loup (8) |
| 222. | FC Sainte-Foy-lès-Lyon (10) | 0–5 | SO Pont-de-Chéruy-Chavanoz (8) |
| 223. | Sud Azergues Foot (10) | 0–4 | Stade Amplepuisien (8) |
| 224. | FC Mont Brouilly (9) | 4–1 | ES Chaponost (9) |
| 225. | AS Rhodanienne (10) | 1–1 (2–3 p) | AL Saint-Maurice-l'Exil (9) |
| 226. | AS Pusignan (11) | 0–3 | FC Gerland Lyon (10) |
| 227. | Olympique Vaulx-en-Venlin (10) | 5–2 | Lyon Ouest SC (9) |
| 228. | Claix Football (12) | 3–4 | US Village Olympique Grenoble (11) |
| 229. | FC Tignieu-Jameyzieu (11) | 0–3 | US Corbelin (10) |
| 230. | Olympique Villefontaine (10) | 1–3 | AS Vézeronce-Huert (9) |
| 231. | Noyarey FC (10) | 2–2 (5–4 p) | FC Allobroges Asafia (9) |
| 232. | US Sassenage (9) | 0–3 | FC Varèze (8) |
| 233. | US Saint-Paul-de-Varces (11) | 1–4 | US Jarrie-Champ (9) |
| 234. | EF des Étangs (11) | 1–1 (2–3 p) | AS Tullins-Fures (10) |
| 235. | CS Miribel (11) | 1–1 (3–4 p) | US Ruy Montceau (10) |
| 236. | AS Crossey (12) | 3–0 | AS Saint-Joseph-de-Rivière (11) |
| 237. | Eyzin Saint-Sorlin FC (12) | 0–1 | Union Nord Iséroise (10) |
| 238. | FC Lauzes (10) | 0–1 | FC Balmes Nord-Isère (9) |
| 239. | FC Velanne (12) | 2–6 | Artas Charantonnay FC (10) |
| 240. | US Chatte (12) | 2–0 | US Ro-Claix (10) |
| 241. | ES Bizonnes-Belmont (12) | 0–3 | FC La Sure (10) |
| 242. | US Saint-Geoire-en-Valdaine (12) | 3–0 | Stade Chabonnais (10) |
| 243. | AS Italienne Européenne Grenoble (9) | 1–0 | FC Voiron-Moirans (8) |
| 244. | Formafoot Bièvre Valloire (9) | 2–2 (5–6 p) | Vallée du Guiers FC (8) |
| 245. | AS Saint-André-le-Gaz (9) | 1–2 | AS Domarin (8) |
| 246. | FC Crolles-Bernin (9) | 2–2 (4–2 p) | AS Ver Sau (8) |
| 247. | ASL Saint-Cassien (9) | 1–2 | FC Seyssins (8) |
| 248. | FC Versoud (9) | 2–4 | OC Eybens (8) |
| 249. | US Dolomoise (10) | 0–1 | Olympique Nord Dauphiné (8) |
| 250. | CS Faramans (10) | 0–1 | ES Rachais (8) |
| 251. | FC Agnin (12) | 0–5 | AS Saint-Lattier (11) |
| 252. | FC Vallée de l'Hien (11) | 3–0 | Saint-Martin-d'Hères FC (9) |
| 253. | AC Poisat (11) | 1–1 (3–4 p) | MJC Saint-Hilaire-de-la-Côte (11) |
| 254. | Eclose Châteauvilain Badinières Football (11) | 5–4 | FC des Collines (10) |
| 255. | FC Chirens (12) | 1–1 (4–2 p) | AS Cheyssieu (12) |
| 256. | ÉS Montrondaise (11) | 0–3 | FC Saint-Étienne (8) |
| 257. | ABH FC (12) | 3–2 | FC Montagnes du Matin (10) |
| 258. | FC Bords de Loire (11) | 1–5 | AS Savigneux-Montbrison (8) |
| 259. | ES Saint-Christo-Marcenod (10) | 0–0 (2–4 p) | Sorbiers-La Talaudière (8) |
| 260. | AS Aveizieux (10) | 1–1 (5–6 p) | Anzieux Foot (8) |
| 261. | AS Saint-Ferréol Gampille Firminy (12) | 0–8 | Olympique Saint-Étienne (11) |
| 262. | FC Bonson-Saint-Cyprien (12) | 3–3 (4–2 p) | OC Ondaine (11) |
| 263. | US Bussières (11) | 1–3 | Feu Vert Saint-Chamond (11) |
| 264. | FC Saint-Joseph-Saint-Martin (10) | 1–3 | Olympique Le Coteau (10) |
| 265. | AS La Chaumière (13) | 0–4 | Montreynaud 42 (13) |
| 266. | Saint-Étienne UC Terrenoire (11) | 1–1 (3–4 p) | Sury SC (10) |
| 267. | ES Haut Forez (12) | 3–0 | US Villars (8) |
| 268. | US Métare Saint-Étienne Sud Est (11) | 2–0 | AS Châteauneuf (9) |
| 269. | Périgneux Saint-Maurice Foot (11) | 1–3 | GS Dervaux Chambon-Feugerolles (9) |
| 270. | FC Marcellinois (12) | 1–12 | AS Algérienne Chambon-Feugerolles (9) |
| 271. | CO La Rivière (11) | 3–0 | Olympique du Montcel (9) |
| 272. | FC Genilac (12) | 1–2 | AF Pays de Coise (9) |
| 273. | AS Noirétable (11) | 1–4 | CS Crémeaux (10) |
| 274. | US Filerin (11) | 3–3 (4–3 p) | Roanne AS Parc du Sport (8) |
| 275. | FC Perreux (11) | 0–6 | FC Loire Sornin (10) |
| 276. | AS Astrée (12) | 1–6 | FCI Saint-Romain-le-Puy (10) |
| 277. | FC Boisset-Chalain (10) | 2–3 | USG La Fouillouse (8) |
| 278. | FC Bourguisan (10) | 3–1 | AC Rive-de-Gier (8) |
| 279. | Lignon FC (11) | 0–0 (4–5 p) | ES Champdieu-Marcilly (10) |
| 280. | SS Ussonaise (11) | 1–1 (5–4 p) | US Sud Forézienne (10) |
| 281. | FC Saint-Martin-la-Sauveté (12) | 0–7 | Forez Donzy FC (9) |
| 282. | AS Cours (13) | 0–9 | ES Dyonisienne (11) |
| 283. | FC Belette de Saint-Léger (13) | 3–1 | AS Saint Haonnoise (11) |
| 284. | US Briennon (11) | 1–6 | US Renaisonnaise Apchonnaise (10) |
| 285. | FC Régny (13) | 0–10 | AS Saint-Symphorien-de-Lay (11) |
| 286. | US Parigny Saint-Cyr (11) | 4–0 | FC Commelle-Vernay (9) |
| 287. | FC Montagny (12) | 0–3 | AS Pouilly-les-Nonains (10) |
| 288. | Nord Roannais (11) | 3–1 | ASL Portugais Roanne (10) |
| 289. | Rhins Trambouze Foot (11) | 2–2 (2–4 p) | US Villerest (10) |
| 290. | Gand Olympique Avenir Loire Football (11) | 1–1 (4–3 p) | Riorges FC (10) |
| 291. | Olympique Est Roannais (11) | 3–0 | Rhins Sportif Saint Victor (13) |
| 292. | Bellegarde Sports (13) | 0–0 (4–5 p) | AS Chambéon-Magneux (9) |
| 293. | AS Cuzieu (13) | 1–2 | Toranche FC (11) |
| 294. | AS Finerbal Nervieux Balbigny (11) | 0–3 | US Ecotay-Moingt (10) |
| 295. | Haut Pilat Interfoot (11) | 0–3 | L'Étrat-La Tour Sportif (8) |
| 296. | AL Saint-Genest-Lerpt (12) | 3–0 | FC Montrambert Ricamar (10) |
| 297. | AS Couzan (11) | 0–2 | AS Saint-Just-Saint-Rambert (10) |
| 298. | FC Saint-Paul-en-Jarez (9) | 3–0 | SEL Saint-Priest-en-Jarez (8) |
| 299. | ES Doizieux-La Terrasse-sur-Dorlay (11) | 1–14 | US L'Horme (10) |
| 300. | FC Plaine Cleppé/Poncins (12) | 3–2 | Saint-Romain-les-Atheux Sports (12) |
| 301. | ES Chomérac (10) | 0–2 | ASF Pierrelatte (8) |
| 302. | AS Portugaise Valence (10) | 0–3 | SC Cruas (8) |
| 303. | Allex-Chabrillan-Eurre FC (11) | 1–5 | Olympique Ruomsois (8) |
| 304. | AS Cornas (10) | 0–3 | Olympique Centre Ardèche (9) |
| 305. | US Ancône (11) | 1–2 | US Portes Hautes Cévennes (9) |
| 306. | CS Châteauneuf-de-Galaure (12) | 1–1 (3–5 p) | AAJ Saint-Alban-d'Ay (11) |
| 307. | AS Berg-Helvie (10) | 2–1 | FC Montélimar (10) |
| 308. | ES Trèfle (12) | 2–6 | FC Muzolais (10) |
| 309. | AS La Sanne (11) | 0–3 | RC Mauves (10) |
| 310. | FC Clérieux-Saint-Bardoux-Granges-les-Beaumont (12) | 1–1 (1–3 p) | Entente Sarras Sports Saint-Vallier (10) |
| 311. | Glun FC (13) | 1–2 | US Peyrins (12) |
| 312. | RC Savasson (12) | 2–0 | US Meysse (13) |
| 313. | US Beaufortoise (12) | 1–3 | US Rochemaure (11) |
| 314. | US Baixoise (12) | 1–4 | RC Tournon-Tain (11) |
| 315. | FC Sauzet (12) | 1–4 | AS Homenetmen Bourg-lès Valence (11) |
| 316. | Inter Haute Herbasse (12) | 3–0 | ES Malissardoise (12) |
| 317. | CS Lapeyrousien (12) | 0–7 | US Pont-La Roche (11) |
| 318. | AS Génissieux (12) | 1–3 | US Davézieux-Vidalon (10) |
| 319. | US Saint-Just-Saint-Marcel (11) | 7–1 | FR Allan (10) |
| 320. | FC Plateau Ardèchois (11) | 3–0 | AS Saint-Barthélemy-de-Vals (12) |
| 321. | US Vals-les-Bains (11) | 0–4 | US Vallée du Jabron (11) |
| 322. | US Bas-Vivarais (11) | 4–0 | AS Coucouron (11) |
| 323. | FC Saint-Didier-sous-Aubenas (12) | 1–1 (4–5 p) | US Saint-Gervais-sur-Roubion (11) |
| 324. | CS Malataverne (12) | 1–12 | AS Roussas-Granges-Gontardes (11) |
| 325. | US Drôme Provence (12) | 3–8 | Diois FC (11) |
| 326. | AS Cancoise (12) | 2–1 | FC Hauterive (11) |
| 327. | FC Goubetois (12) | 2–6 | AS Vallée du Doux (11) |
| 328. | JS Saint-Paul-lès-Romans (12) | 2–0 | US Saint Martin-de-Valamas (12) |
| 329. | ÉS Saint-Jeure-d'Ay-Marsan (12) | 0–2 | Vallis Auréa Foot (11) |
| 330. | CO Châteauneuf-du-Rhône (12) | 2–3 | JS Livron (12) |
| 331. | AS Saint-Barthélemy-Grozon (12) | 3–0 | FC Hermitage (11) |
| 332. | US 2 Vallons (12) | 3–3 (4–5 p) | EA Montvendre (11) |
| 333. | FC Rochegudien (12) | 0–0 (3–4 p) | FC Aubenas (11) |
| 334. | ES Beaumonteleger (11) | 2–0 | FC Rambertois (11) |
| 335. | FC 540 (11) | 1–1 (4–3 p) | Olympique Saint-Montanais (12) |
| 336. | FC Baume Montségur (13) | 1–0 | FC La Coucourde (12) |
| 337. | US Lussas (12) | 6–1 | FC Saint-Restitut (13) |
| 338. | ES Le Laris-Montchenu (13) | 1–6 | AS Roiffieux (12) |
| 339. | FC Rochepaule (13) | 1–2 | US Veyras (12) |
| 340. | AS Beauvallon (13) | 2–2 (3–4 p) | OS Vallée de l'Ouvèze (12) |
| 341. | AS Saint-Marcelloise (12) | 1–0 | AS Saint-Priest 07 (12) |
| 342. | FC Bren (12) | 2–1 | FC Turquoise (12) |
| 343. | FC Montmiral-Parnans (12) | 3–2 | ES Boulieu-lès-Annonay (10) |
| 344. | FC Vallon-Pont d'Arc (12) | 3–6 | FC Tricastin (10) |
| 345. | AS Véore Montoison (10) | 3–1 | Valence FC (9) |
| 346. | FC Larnage-Serves (11) | 0–1 | Football Mont-Pilat (9) |
| 347. | ES Nord Drôme (11) | 0–6 | CO Châteauneuvois (9) |
| 348. | CO Donzère (11) | 1–0 | US Mours (9) |
| 349. | AS Dolon (11) | 1–0 | FC Portois (9) |
| 350. | SC Piraillon (12) | 3–1 | FC Colombier Saint Barthélemy (12) |
| 351. | Espérance Hostunoise (10) | 3–2 | Rhône Crussol Foot 07 (8) |
| 352. | FC Félines-Saint-Cyr-Peaugres (11) | 0–7 | FC Eyrieux Embroye (8) |
| 353. | IF Barbières-Bésayes-Rochefort-Samson-Marches (11) | 2–1 | US Chanas Sablons Serrières (9) |
| 354. | FC Cheylarois (11) | 1–4 | FC Bourg-lès-Valence (9) |
| 355. | US Montmeyran (10) | 0–2 | FC Péageois (9) |
| 356. | US Montélier (11) | 0–1 | AS Donatienne (8) |
| 357. | US Val d'Ay (10) | 0–2 | US Reventin (9) |
| 358. | FC Châtelet (10) | 3–3 (3–5 p) | PS Romanaise (9) |
| 359. | AS Mont Jovet Bozel (11) | 0–4 | AS Ugine (9) |
| 360. | US Grand Mont La Bâthie (10) | 0–4 | FC Haute Tarentaise (8) |
| 361. | AS La Bridoire (12) | 2–6 | Montmélian AF (9) |
| 362. | USC Aiguebelle (10) | 0–1 | Nivolet FC (8) |
| 363. | FC des Bauges (12) | 0–6 | UO Albertville (9) |
| 364. | FC Saint-Michel Sports (11) | 1–1 (3–1 p) | US Grignon (9) |
| 365. | US Modane (10) | 0–2 | CA Maurienne (8) |
| 366. | US Saint-Rémy-de-Maurienne (11) | 0–4 | US La Ravoire (9) |
| 367. | FC Laissaud (10) | 4–0 | Cognin Sports (8) |
| 368. | AS Novalaise (10) | 0–2 | US Chartreuse Guiers (9) |
| 369. | AS Haute Combe de Savoie | 0–3 | AS Cuines-La Chambre Val d'Arc (10) |
| 370. | FC Villargondran (11) | 0–5 | FC Belle Étoile Mercury (9) |
| 371. | Association Portugaise Croix Rouge Chambéry (10) | 6–1 | Saint-Pierre SF (10) |
| 372. | US Domessin (11) | 0–4 | FC Chambotte (8) |
| 373. | AS Brison-Saint-Innocent (11) | 0–3 | US Motteraine (9) |
| 374. | ES Bourget du Lac (11) | 1–3 | ES Drumettaz-Mouxy (8) |
| 375. | Challes SF (12) | 5–2 | FC Saint-Baldoph (11) |
| 376. | FC La Rochette (11) | 1–5 | JS Chambéry (8) |
| 377. | Cœur de Savoie (11) | 1–3 | US Pontoise (9) |
| 378. | FC Sud Lac (11) | 0–7 | Entente Val d'Hyères (8) |
| 379. | CA Yennne (11) | 1–3 | Chambéry Sport 73 (10) |
| 380. | CS Veigy-Foncenex (11) | 1–7 | CS Amphion Publier (8) |
| 381. | US Pers-Jussy (12) | 0–7 | AJ Ville-la-Grand (10) |
| 382. | AS Le Lyaud-Armoy (11) | 1–3 | SS Allinges (9) |
| 383. | FC Cranves-Sales (11) | 0–0 (3–4 p) | FC Ballaison (9) |
| 384. | FC Gavot (12) | 0–2 | AG Bons-en-Chablais (10) |
| 385. | Arthaz Sports (13) | 2–4 | ES Douvaine-Loisin (11) |
| 386. | FC Marcellaz-Albanais (11) | 0–0 (3–2 p) | FC Chéran (9) |
| 387. | CS Saint-Pierre (11) | 2–4 | US Pringy (8) |
| 388. | FC Foron (8) | 11–0 | AS Lac Bleu (11) |
| 389. | ES Lanfonnet (12) | 2–0 | CS La Balme-de-Sillingy (10) |
| 390. | CS Megève (12) | 0–2 | CS Ayze (10) |
| 391. | FC Villy-le-Pelloux (13) | 2–2 (6–7 p) | FC Frangy (11) |
| 392. | AS Cornier (12) | 2–3 | CSA Poisy (10) |
| 393. | FC Semine (11) | 1–1 (0–3 p) | CO Chavanod (10) |
| 394. | ES Meythet (11) | 2–2 (4–2 p) | Olympique Cran (10) |
| 395. | AS Thonon (11) | 0–3 | JS Reignier (9) |
| 396. | CS Vacheresse Vallée d'Abondance (12) | 1–3 | SC Morzine Vallée d'Aulps (10) |
| 397. | FC Anthy Sport (12) | 0–3 | ES Fillinges (10) |
| 398. | AS Épagny-Metz-Tessy (12) | 0–1 | FC La Filière (10) |
| 399. | CSL Perrignier (12) | 1–3 | FC Vuache (10) |
| 400. | Bonne AC (13) | 0–3 | ES Sciez (11) |
| 401. | FC Aravis (13) | 1–0 | AS Parmelan Villaz (11) |
| 402. | AS Évires (11) | 1–4 | FC Thônes (9) |
| 403. | FC Dingy-Saint-Clair (11) | 5–5 (4–3 p) | Beaumont Collonges FC (10) |
| 404. | US Argonay (10) | 2–2 (5–4 p) | US Semnoz-Vieugy (8) |
| 405. | ES Thyez (10) | 1–1 (5–6 p) | Haut Giffre FC (9) |
| 406. | US Challex (12) | 0–3 | Échenevex-Ségny-Chevry Olympique (10) |
| 407. | FC Leman Presqu'île (13) | 2–0 | FRS Champanges (11) |
| 408. | US Margencel (11) | 2–3 | Marignier Sports (9) |
| 409. | FC Combloux (10) | 0–5 | ES Amancy (8) |
| 410. | FC Arenthon-Scientrier (12) | 1–6 | ASC Sallanches (10) |
| 411. | ES Valleiry (10) | 1–3 | FC Cruseilles (8) |
| 412. | US Vétraz-Monthoux (12) | 0–3 | US Divonne (8) |
| 413. | Football Sud Gessien (11) | 0–5 | US Annemasse-Gaillard (8) |
| 414. | ES Viry (11) | 2–5 | Pays de Gex FC (8) |
| 415. | AS Prévessin-Moëns (11) | 0–4 | AS Sillingy (9) |
| 416. | AS Portugais Annecy (12) | 0–7 | ES Cernex (10) |
| 417. | ES Saint-Jeoire-La Tour (10) | 0–0 (4–3 p) | US Mont Blanc (8) |
| 418. | FC Les Houches-Servoz (13) | 0–8 | FC Cluses (11) |
* 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Tie won by means of forfeit.
* 1 2 3 4 5 6 7 8 9 Tie reversed from original draw.
* ↑ AS Haute Combe de Savoie entered into a merger with US Grignon after the draw was made, so were ineligible to play.

### Second round

These matches were played on 4, 5 and 8 September 2021.
Second round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | Olympique Saint-Étienne (11) | 0–0 (4–3 p) | AS Savigneux-Montbrison (8) |
| 2. | AS Louchy (8) | 3–3 (3–2 p) | Commentry FC (9) |
| 3. | FC La Sure (10) | 1–2 | FC Crolles-Bernin (9) |
| 4. | AS Algérienne Chambon-Feugerolles (9) | 0–0 (2–4 p) | ES Veauche (7) |
| 5. | ES Montagne Bourbonnaise (11) | 0–3 | Bézenet-Doyet Foot (8) |
| 6. | US Toque Huriel (11) | 1–2 | FC Souvigny (10) |
| 7. | Carladez-Goul Sportif (9) | 3–1 | FC des Quatre Vallées (9) |
| 8. | ES Riomois-Condat (9) | 1–1 (4–1 p) | AS Espinat (9) |
| 9. | US Chapdes-Beaufort (10) | 0–3 | AS Job (9) |
| 10. | US Saint-Gervaisienne (10) | 1–6 | Clermont Outre-Mer (10) |
| 11. | FC Nord Limagne (9) | 3–1 | FC Vertaizon (8) |
| 12. | Espérance Ceyratois Football (8) | 5–1 | FC Lezoux (9) |
| 13. | AS Saint-Ours (10) | 0–1 | US Saint-Beauzire (8) |
| 14. | US Davézieux-Vidalon (10) | 3–0 | AS Homenetmen Bourg-lès Valence (11) |
| 15. | Olympique Centre Ardèche (9) | 1–0 | Olympique Ruomsois (8) |
| 16. | AG Bons-en-Chablais (10) | 3–0 | SS Allinges (9) |
| 17. | SC Morzine Vallée d'Aulps (10) | 1–3 | Haut Giffre FC (9) |
| 18. | ASC Sallanches (10) | 3–3 (3–2 p) | ES Amancy (8) |
| 19. | AC Creuzier-le-Vieux (8) | 1–2 | AS Nord Vignoble (8) |
| 20. | Étoile Moulins Yzeure (9) | 0–4 | AS Cheminots Saint-Germain (7) |
| 21. | US Trezelles (10) | 1–2 | AS Varennes-sur-Allier (8) |
| 22. | AS Chassenard Luneau (11) | 2–3 | SC Gannat (9) |
| 23. | Stade Saint-Yorre (9) | 3–1 | US Biachette Désertines (10) |
| 24. | FC Creuzier-le-Neuf (12) | 0–6 | JS Neuvy (9) |
| 25. | AS Saint-Loup (12) | 2–3 | AS Neuilly-le-Réal (11) |
| 26. | US Abrest (11) | 4–0 | US Saulcet-Le Theil (11) |
| 27. | US Coeur Allier (12) | 1–4 | US Vallon (10) |
| 28. | CS Thielois (12) | 3–3 (3–2 p) | Espoir Molinetois (11) |
| 29. | FC Billy-Crechy (10) | 1–3 | Bourbon Sportif (9) |
| 30. | AL Quinssaines (10) | 1–3 | US Bien-Assis (11) |
| 31. | FC Haut d'Allier (10) | 0–2 | AA Lapalisse (7) |
| 32. | Magnet/Seuillet/Saint-Gérand-le-Puy Foot (11) | 0–1 | AS Dompierroise (9) |
| 33. | US Vendat (8) | 4–3 | SCA Cussét (7) |
| 34. | US Chevagnes (11) | 1–3 | SC Saint-Pourcain (7) |
| 35. | AC Franco-Algérienne (10) | 1–7 | FC Châtel-Guyon (7) |
| 36. | FC Massiac-Molompize-Blesle (10) | 4–1 | Saint-Georges SL (11) |
| 37. | FC Moussages (9) | 3–4 | ES Pierrefortaise (8) |
| 38. | ES Saint-Mamet (9) | 2–1 | US Vallée de l'Authre (7) |
| 39. | Aspre FC Fontanges (13) | 1–2 | AS Belbexoise (9) |
| 40. | CS Vézac (9) | 2–3 | US Murat (8) |
| 41. | US Crandelles (9) | 1–2 | Parlan-Le Rouget FC (8) |
| 42. | US La Chapelle-Laurent (10) | 0–9 | Entente Nord Lozère (7) |
| 43. | ES Vebret-Ydes (11) | 1–0 | AS Yolet (9) |
| 44. | FC Junhac-Montsalvy (10) | 0–2 | Sud Cantal Foot (8) |
| 45. | AS Sansacoise (8) | 4–0 | FC Ally Mauriac (7) |
| 46. | FC Aurec (10) | 1–2 | US Vals Le Puy (9) |
| 47. | Vigilante Saint-Pal-de-Mons (10) | 2–4 | Olympic Saint-Julien-Chapteuil (8) |
| 48. | AS Villettoise (9) | 1–2 | AS Chadrac (8) |
| 49. | US Montfaucon Montregard Raucoules (10) | 3–4 | FC Arzon (10) |
| 50. | FJEP Freycenets Saint-Jeures (10) | 1–4 | US Bains-Saint-Christophe (9) |
| 51. | AS Saint-Vidal (10) | 1–3 | AS Laussonne (9) |
| 52. | AS Grazac-Lapte (9) | 0–4 | US Sucs et Lignon (7) |
| 53. | FC Saint-Germain-Laprade (10) | 2–2 (2–4 p) | AS Loudes (8) |
| 54. | FC Dunières (8) | 3–1 | SC Langogne (7) |
| 55. | AS Pertuis (11) | 2–6 | Retournac Sportif (7) |
| 56. | US Fontannoise (8) | 0–2 | US Brioude (7) |
| 57. | AS Cheminots Langeac (9) | 4–4 (3–2 p) | Association Vergongheon-Arvant (7) |
| 58. | Seauve Sports (8) | 2–4 | AS Emblavez-Vorey (7) |
| 59. | AS Cunlhat (11) | 0–1 | ES Couze Pavin (11) |
| 60. | US Limons (10) | 1–2 | Dômes-Sancy Foot (8) |
| 61. | AS Roche-Blanche FC (11) | 3–6 | Ecureuils Franc Rosier (9) |
| 62. | ACS Cappadoce (11) | 1–1 (5–4 p) | AS Cellule (9) |
| 63. | CS Pont-de-Dore (10) | 2–3 | US Issoire (7) |
| 64. | US Messeix Bourg-Lastic (11) | 2–2 (4–5 p) | US Gerzat (9) |
| 65. | FC Bromont-Lamothe/Montfermy (11) | 1–3 | RC Charbonnières-Paugnat (10) |
| 66. | CS Saint-Bonnet-près-Riom (10) | 1–6 | US Beaumontoise (7) |
| 67. | FF Chappes (11) | 1–1 (9–10 p) | SC Billom (9) |
| 68. | Aulnat Sportif (12) | 1–5 | US Bassin Minier (9) |
| 69. | FC Sauxillanges Saint-Babel Brenat (9) | 1–2 | FCUS Ambert (7) |
| 70. | US Ménétrol (12) | 2–1 | FC Mirefleurs (10) |
| 71. | Clermont Ouvoimoja (10) | 2–2 (6–7 p) | FC Cournon-d'Auvergne (7) |
| 72. | FC Martres-Lussat (9) | 0–0 (5–3 p) | US Vic-le-Comte (8) |
| 73. | US Beauregard-Vendon (12) | 1–1 (3–2 p) | AS Enval-Marsat (8) |
| 74. | US Les Martres-de-Veyre (8) | 2–0 | CS Pont-du-Château (7) |
| 75. | UJ Clermontoise (8) | 0–1 | US Mozac (8) |
| 76. | AS Hautecourt-Romanèche (11) | 1–3 | Olympique Sud Revermont 01 (10) |
| 77. | Côtière Meximieux Villieu (12) | 0–2 | CS Lagnieu (8) |
| 78. | FC Saint-Maurice-de-Gourdans (11) | 2–6 | FC Dombes (10) |
| 79. | ES Val de Saône (10) | 0–0 (3–5 p) | FC Veyle Sâone (8) |
| 80. | Entente Bas Bugey Rhône (11) | 3–5 | Ambérieu FC (9) |
| 81. | AS Portugaise Vaulx-en-Velin (10) | 3–0 | FC Montluel (13) |
| 82. | Entente Saint-Martin-du-Frêne/Maillat/Combe du Val (11) | 1–1 (2–4 p) | US Arbent Marchon (8) |
| 83. | FC Bressans (8) | 2–1 | FC Plaine Tonique (9) |
| 84. | FC Curtafond-Confrançon-Saint-Martin-Saint-Didier (10) | 1–2 | CS Viriat (8) |
| 85. | Bourg Sud (9) | 0–3 | CS Neuville (7) |
| 86. | US Vaux-en-Bugey (12) | 1–1 (3–1 p) | CS Belley (9) |
| 87. | AS Genay (11) | 3–1 | AS Attignat (10) |
| 88. | FC Saint-Vulbas Plaine de l'Ain (10) | 1–10 | Oyonnax Plastics Vallée FC (8) |
| 89. | Olympique Buyatin (11) | 0–10 | Valserine FC (11) |
| 90. | FC Manziat (10) | 1–2 | SC Portes de l'Ain (9) |
| 91. | AS Travailleurs Turcs Oyonnax (11) | 2–4 | AS Montréal-la-Cluse (9) |
| 92. | ÉS Liergues (9) | 0–1 | FC Dombes-Bresse (9) |
| 93. | Belleville Football Beaujolais (8) | 1–6 | US Feillens (7) |
| 94. | Caluire SC (8) | 0–3 | FC Bords de Saône (7) |
| 95. | AS Saint-Étienne-sur-Chalaronne (12) | 2–3 | AS Diémoz (10) |
| 96. | FC Rive Droite (10) | 1–1 (4–3 p) | FC Reneins Vauxonne (11) |
| 97. | Beaujolais Football (10) | 3–1 | FC Denicé Arnas (11) |
| 98. | AS Grièges Pont de Veyle (12) | 1–3 | US Formans (12) |
| 99. | ASA Clochemerle (11) | 2–9 | ES Bressane Marboz (7) |
| 100. | AS Bron Grand Lyon (8) | 4–0 | FC Pays de l'Arbresle (9) |
| 101. | FC Colombier-Satolas (9) | 3–0 | US Meyzieu (8) |
| 102. | FC Chaponnay-Marennes (8) | 8–2 | UGA Lyon-Décines (9) |
| 103. | JS Cellieu (10) | 4–1 | Ménival FC (9) |
| 104. | AS Toussieu (11) | 1–3 | CS Meginand (9) |
| 105. | Feyzin Club Belle Étoile (8) | 0–5 | AS Villeurbanne Éveil Lyonnais (9) |
| 106. | ASC Générale Routière Maïa Sonnier (11) | 0–8 | AS Bellecour-Perrache (8) |
| 107. | ES Genas Azieu (9) | 2–3 | FC Saint-Cyr Collonges au Mont d'Or (8) |
| 108. | ES Saint-Priest (10) | 2–6 | AS Montchat Lyon (7) |
| 109. | ES Gleizé (11) | 1–6 | US Millery-Vourles (8) |
| 110. | ACS Mayotte du Rhône (11) | 0–4 | AS Saint-Martin-en-Haut (9) |
| 111. | FC La Giraudière (11) | 1–5 | CO Saint-Fons (9) |
| 112. | US Montanay (11) | 0–2 | FC Sourcieux-les-Mines (11) |
| 113. | FC Sévenne (9) | 3–1 | JSO Givors (10) |
| 114. | FC Fontaines-sur-Saône (10) | 1–4 | Sporting Nord-Isère (8) |
| 115. | FC Antillais Villeurbanne (13) | 1–2 | Association Chandieu-Heyrieux (9) |
| 116. | Latino AFC Lyon (12) | 0–1 | Sud Lyonnais Foot (7) |
| 117. | US Loire-Saint-Romain (10) | 1–0 | Domtac FC (7) |
| 118. | US Villette-d'Anthon-Janneyrais (13) | 8–3 | SC Revolée (13) |
| 119. | Saint-Alban Sportif (10) | 2–6 | ÉS Trinité Lyon (7) |
| 120. | AS Sornins Réunis (12) | 0–8 | AS Saint-Forgeux (10) |
| 121. | Lyon Croix Rousse Football (11) | 0–1 | Olympique Saint-Genis-Laval (7) |
| 122. | FC Croix Roussien (10) | 3–1 | CS Ozon (11) |
| 123. | Chambost-Allières-Saint-Just-d'Avray (12) | 0–9 | Stade Amplepuisien (8) |
| 124. | CAS Cheminots Oullins Lyon (10) | 6–0 | US Côteaux Lyonnais (11) |
| 125. | FC Mont Brouilly (9) | 2–1 | SO Pont-de-Chéruy-Chavanoz (8) |
| 126. | AL Saint-Maurice-l'Exil (9) | 2–1 | Olympique Nord Dauphiné (8) |
| 127. | Beaucroissant FC (11) | 1–3 | Moirans FC (12) |
| 128. | AS Fontaine (12) | 6–0 | Vourey Sports (13) |
| 129. | US Abbaye (13) | 5–2 | UO Portugal Saint-Martin-d'Hères (10) |
| 130. | FC Virieu-Valondras (11) | 1–10 | FC Vallée de la Gresse (8) |
| 131. | CS Voreppe (10) | 1–6 | ES Manival (7) |
| 132. | Rives SF (10) | 4–1 | AS Grésivaudan (11) |
| 133. | Isle d'Abeau FC (10) | 0–2 | ASF Portugais (11) |
| 134. | Olympique Les Avenières (10) | 3–3 (5–6 p) | FC Charvieu-Chavagneux (8) |
| 135. | JS Saint-Georgeoise (11) | 13–0 | US Cassolards Passageois (12) |
| 136. | US Village Olympique Grenoble (11) | 1–5 | Noyarey FC (10) |
| 137. | US Corbelin (10) | 1–4 | FC Varèze (8) |
| 138. | AS Vézeronce-Huert (9) | 1–5 | MOS Trois Rivières (7) |
| 139. | US Jarrie-Champ (9) | 1–1 (3–2 p) | Football Côte Saint-André (7) |
| 140. | AS Tullins-Fures (10) | 0–5 | US Ruy Montceau (10) |
| 141. | AS Crossey (12) | 1–5 | Artas Charantonnay FC (10) |
| 142. | Union Nord Iséroise (10) | 0–5 | AS Domarin (8) |
| 143. | FC Balmes Nord-Isère (9) | 2–10 | Vallée du Guiers FC (8) |
| 144. | US Chatte (12) | 0–4 | AS Italienne Européenne Grenoble (9) |
| 145. | FC Vallée de l'Hien (11) | 0–0 (4–3 p) | OC Eybens (8) |
| 146. | AS Saint-Lattier (11) | 0–5 | ES Rachais (8) |
| 147. | MJC Saint-Hilaire-de-la-Côte (11) | 0–3 | Olympique Saint-Marcellin (7) |
| 148. | Eclose Châteauvilain Badinières Football (11) | 1–5 | FC La Tour-Saint-Clair (7) |
| 149. | FC Chirens (12) | 0–6 | US Gières (7) |
| 150. | US Peyrins (12) | 1–3 | RC Savasson (12) |
| 151. | US Rochemaure (11) | 5–0 | RC Tournon-Tain (11) |
| 152. | US Pont-La Roche (11) | 5–0 | Inter Haute Herbasse (12) |
| 153. | US Vallée du Jabron (11) | 0–1 | US Bas-Vivarais (11) |
| 154. | ES Beaumonteleger (11) | 2–2 (4–3 p) | FC Valdaine (7) |
| 155. | AS Donatienne (8) | 2–2 (5–6 p) | US Reventin (9) |
| 156. | IF Barbières-Bésayes-Rochefort-Samson-Marches (11) | 3–5 | Football Mont-Pilat (9) |
| 157. | US Veyras (12) | 2–8 | FC Péageois (9) |
| 158. | OS Vallée de l'Ouvèze (12) | 0–8 | CO Châteauneuvois (9) |
| 159. | US Lussas (12) | 6–1 | FC 540 (11) |
| 160. | FC Bren (12) | 6–0 | FC Montmiral-Parnans (12) |
| 161. | CO Donzère (11) | 0–1 | FC Eyrieux Embroye (8) |
| 162. | FC Tricastin (10) | 1–3 | FC Aubenas (11) |
| 163. | FC Annonay (8) | 1–0 | US Monistrol (8) |
| 164. | SC Piraillon (12) | 1–11 | AS Chavanay (7) |
| 165. | US Saint-Just-Saint-Marcel (11) | 2–2 (2–3 p) | FC Chabeuil (7) |
| 166. | SC Cruas (8) | 0–6 | AS Sud Ardèche (7) |
| 167. | AS Berg-Helvie (10) | 2–4 | Entente Crest-Aouste (7) |
| 168. | US Saint-Gervais-sur-Roubion (11) | 4–2 | AS Roussas-Granges-Gontardes (11) |
| 169. | JS Livron (12) | 4–3 | PS Romanaise (9) |
| 170. | Diois FC (11) | 4–3 | FC Plateau Ardèchois (11) |
| 171. | AS Vallée du Doux (11) | 2–0 | AS Cancoise (12) |
| 172. | Vallis Auréa Foot (11) | 4–0 | JS Saint-Paul-lès-Romans (12) |
| 173. | ASF Pierrelatte (8) | 5–3 | US Portes Hautes Cévennes (9) |
| 174. | FC Bourg-lès-Valence (9) | 1–4 | UMS Montélimar (7) |
| 175. | AAJ Saint-Alban-d'Ay (11) | 0–2 | FC Muzolais (10) |
| 176. | RC Mauves (10) | 3–2 | Entente Sarras Sports Saint-Vallier (10) |
| 177. | FC Baume Montségur (13) | 0–8 | AS Véore Montoison (10) |
| 178. | AS Roiffieux (12) | 8–0 | AS Saint-Marcelloise (12) |
| 179. | AS Dolon (11) | 0–2 | Espérance Hostunoise (10) |
| 180. | CS Crémeaux (10) | 4–0 | AS Moissat (10) |
| 181. | FC Belette de Saint-Léger (13) | 0–0 (4–2 p) | ES Dyonisienne (11) |
| 182. | US Renaisonnaise Apchonnaise (10) | 2–3 | FC Loire Sornin (10) |
| 183. | AS Saint-Symphorien-de-Lay (11) | 0–2 | Roannais Foot 42 (7) |
| 184. | AS Pouilly-les-Nonains (10) | 1–2 | US Parigny Saint-Cyr (11) |
| 185. | US Villerest (10) | 3–1 | Nord Roannais (11) |
| 186. | Olympique Est Roannais (11) | 1–1 (3–1 p) | Gand Olympique Avenir Loire Football (11) |
| 187. | Toranche FC (11) | 0–2 | AS Chambéon-Magneux (9) |
| 188. | FC Bourguisan (10) | 3–4 | FC Saint-Étienne (8) |
| 189. | FCI Saint-Romain-le-Puy (10) | 3–2 | USG La Fouillouse (8) |
| 190. | US Filerin (11) | 2–1 | Anzieux Foot (8) |
| 191. | FC Bonson-Saint-Cyprien (12) | 0–12 | L'Étrat-La Tour Sportif (8) |
| 192. | US Ecotay-Moingt (10) | 1–10 | US Saint-Galmier-Chambœuf (8) |
| 193. | Montreynaud 42 (13) | 0–4 | Sorbiers-La Talaudière (8) |
| 194. | ABH FC (12) | 3–2 | Olympique Le Coteau (10) |
| 195. | Feu Vert Saint-Chamond (11) | 5–0 | US L'Horme (10) |
| 196. | Sury SC (10) | 2–3 | AS Saint-Just-Saint-Rambert (10) |
| 197. | US Métare Saint-Étienne Sud Est (11) | 3–0 | ES Haut Forez (12) |
| 198. | GS Dervaux Chambon-Feugerolles (9) | 1–3 | Saint-Chamond Foot (7) |
| 199. | CO La Rivière (11) | 0–3 | Côte Chaude Sportif (7) |
| 200. | FC Plaine Cleppé/Poncins (12) | 1–5 | AF Pays de Coise (9) |
| 201. | ES Champdieu-Marcilly (10) | 2–4 | Forez Donzy FC (9) |
| 202. | SS Ussonaise (11) | 1–0 | AL Saint-Genest-Lerpt (12) |
| 203. | FC Saint-Paul-en-Jarez (9) | 1–4 | FC Roche-Saint-Genest (7) |
| 204. | AS Ugine (9) | 4–2 | FC Haute Tarentaise (8) |
| 205. | FC Saint-Michel Sports (11) | 3–1 | CA Maurienne (8) |
| 206. | UO Albertville (9) | 0–2 | ES Tarentaise (7) |
| 207. | Montmélian AF (9) | 0–2 | Nivolet FC (8) |
| 208. | AS Cuines-La Chambre Val d'Arc (10) | 0–4 | FC Belle Étoile Mercury (9) |
| 209. | Challes SF (12) | 0–4 | US La Ravoire (9) |
| 210. | US Chartreuse Guiers (9) | 1–5 | JS Chambéry (8) |
| 211. | US Motteraine (9) | 0–0 (4–5 p) | ES Drumettaz-Mouxy (8) |
| 212. | Association Portugaise Croix Rouge Chambéry (10) | 1–3 | FC Chambotte (8) |
| 213. | US Pontoise (9) | 0–3 | FC Laissaud (10) |
| 214. | Chambéry Sport 73 (10) | 0–4 | Entente Val d'Hyères (8) |
| 215. | ES Douvaine-Loisin (11) | 0–0 (2–4 p) | CS Amphion Publier (8) |
| 216. | CS Ayze (10) | 0–6 | AJ Ville-la-Grand (10) |
| 217. | FC Ballaison (9) | 1–2 | JS Reignier (9) |
| 218. | FC Marcellaz-Albanais (11) | 0–2 | US Annecy-le-Vieux (7) |
| 219. | CSA Poisy (10) | 1–4 | US Pringy (8) |
| 220. | ES Lanfonnet (12) | 0–6 | FC Foron (8) |
| 221. | FC Frangy (11) | 4–3 | ES Chilly (7) |
| 222. | CO Chavanod (10) | 6–3 | ES Meythet (11) |
| 223. | ES Fillinges (10) | 6–2 | FC Vuache (10) |
| 224. | ES Sciez (11) | 1–2 | FC La Filière (10) |
| 225. | FC Aravis (13) | 2–2 (4–2 p) | FC Thônes (9) |
| 226. | FC Dingy-Saint-Clair (11) | 0–2 | US Argonay (10) |
| 227. | Échenevex-Ségny-Chevry Olympique (10) | 3–0 | ES Seynod (9) |
| 228. | FC Leman Presqu'île (13) | 0–3 | Marignier Sports (9) |
| 229. | ES Cernex (10) | 2–1 | FC Cruseilles (8) |
| 230. | US Divonne (8) | 3–5 | US Annemasse-Gaillard (8) |
| 231. | AS Sillingy (9) | 3–2 | Pays de Gex FC (8) |
| 232. | FC Cluses (11) | 2–3 | ES Saint-Jeoire-La Tour (10) |
| 233. | US Saint-Geoire-en-Valdaine (12) | 0–8 | FC Seyssins (8) |
| 234. | FC Sayat Argnat (11) | 0–2 | EFC Saint-Amant-Tallende (8) |
| 235. | Saint-Amant et Tallende SC (12) | 0–3 | AS Saint-Genès-Champanelle (8) |
| 236. | EA Montvendre (11) | 2–6 | FC Hermitage (11) |
| 237. | ES Revermontoise (10) | 2–2 (5–3 p) | FC Côtière-Luenaz (10) |
| 238. | FC Gerland Lyon (10) | 1–0 | Olympique Vaulx-en-Venlin (10) |
* ↑ Tie reversed from original draw.

### Third round

These matches were played on 17, 18 and 19 September 2021.
Third round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | Ecureuils Franc Rosier (9) | 1–6 | AS Moulins (5) |
| 2. | SC Gannat (9) | 1–4 | SA Thiers (6) |
| 3. | RC Charbonnières-Paugnat (10) | 3–1 | US Abrest (11) |
| 4. | US Saint-Beauzire (8) | 0–1 | Lempdes Sport (6) |
| 5. | AS Saint-Genès-Champanelle (8) | 1–1 (3–4 p) | Espérance Ceyratois Football (8) |
| 6. | US Ménétrol (12) | 0–1 | Clermont Outre-Mer (10) |
| 7. | Dômes-Sancy Foot (8) | 1–2 | FC Cournon-d'Auvergne (7) |
| 8. | ACS Cappadoce (11) | 0–9 | US Beaumontoise (7) |
| 9. | US Beauregard-Vendon (12) | 1–6 | FCUS Ambert (7) |
| 10. | Bézenet-Doyet Foot (8) | 1–1 (6–7 p) | FA Le Cendre (6) |
| 11. | AS Job (9) | 1–1 (6–5 p) | Stade Saint-Yorre (9) |
| 12. | FC Châtel-Guyon (7) | 0–1 | FC Riom (6) |
| 13. | AS Louchy (8) | 3–3 (3–4 p) | RC Vichy (6) |
| 14. | US Vallon (10) | 1–3 | AS Nord Vignoble (8) |
| 15. | Bourbon Sportif (9) | 1–5 | AA Lapalisse (7) |
| 16. | CS Thielois (12) | 1–8 | US Les Martres-de-Veyre (8) |
| 17. | US Vendat (8) | 1–3 | AS Domerat (6) |
| 18. | AS Neuilly-le-Réal (11) | 1–3 | FC Souvigny (10) |
| 19. | AS Dompierroise (9) | 0–2 | CS Volvic (6) |
| 20. | SC Saint-Pourcain (7) | 0–3 | Montluçon Football (5) |
| 21. | FC Nord Limagne (9) | 2–0 | Cébazat Sports (6) |
| 22. | JS Neuvy (9) | 1–1 (5–4 p) | AS Cheminots Saint-Germain (7) |
| 23. | US Bien-Assis (11) | 2–3 | US Mozac (8) |
| 24. | US Gerzat (9) | 2–2 (4–1 p) | AS Varennes-sur-Allier (8) |
| 25. | SC Billom (9) | 3–1 | Sud Cantal Foot (8) |
| 26. | US Brioude (7) | 2–1 | Ytrac Foot (6) |
| 27. | ES Vebret-Ydes (11) | 1–2 | ES Pierrefortaise (8) |
| 28. | ES Riomois-Condat (9) | 2–3 | US Issoire (7) |
| 29. | AS Belbexoise (9) | 1–1 (2–4 p) | Sporting Chataigneraie Cantal (6) |
| 30. | AS Cheminots Langeac (9) | 4–4 (3–5 p) | ES Saint-Mamet (9) |
| 31. | FC Massiac-Molompize-Blesle (10) | 2–6 | AS Sansacoise (8) |
| 32. | Carladez-Goul Sportif (9) | 2–6 | Entente Nord Lozère (7) |
| 33. | ES Couze Pavin (11) | 1–1 (6–5 p) | US Bassin Minier (9) |
| 34. | Parlan-Le Rouget FC (8) | 0–3 | US Saint-Flour (6) |
| 35. | US Murat (8) | 1–3 | Aurillac FC (5) |
| 36. | Feu Vert Saint-Chamond (11) | 1–2 | AS Chadrac (8) |
| 37. | FC Dunières (8) | 1–3 | AS Saint-Jacques (6) |
| 38. | SS Ussonaise (11) | 1–0 | US Bains-Saint-Christophe (9) |
| 39. | AF Pays de Coise (9) | 2–0 | FC Martres-Lussat (9) |
| 40. | EFC Saint-Amant-Tallende (8) | 0–1 | AS Emblavez-Vorey (7) |
| 41. | FC Arzon (10) | 1–6 | US Blavozy (6) |
| 42. | Football Mont-Pilat (9) | 4–0 | Retournac Sportif (7) |
| 43. | US Vals Le Puy (9) | 0–3 | FC Espaly (6) |
| 44. | AS Loudes (8) | 1–1 (5–4 p) | Olympic Saint-Julien-Chapteuil (8) |
| 45. | AS Laussonne (9) | 0–5 | Velay FC (5) |
| 46. | JS Cellieu (10) | 1–1 (4–3 p) | US Sucs et Lignon (7) |
| 47. | RC Savasson (12) | 1–3 | ASF Pierrelatte (8) |
| 48. | FC Eyrieux Embroye (8) | 0–3 | Entente Crest-Aouste (7) |
| 49. | US Pont-La Roche (11) | 6–1 | JS Livron (12) |
| 50. | FC Annonay (8) | 3–1 | Olympique Centre Ardèche (9) |
| 51. | AS Roiffieux (12) | 0–3 | US Reventin (9) |
| 52. | US Saint-Gervais-sur-Roubion (11) | 2–1 | FC Péageois (9) |
| 53. | Diois FC (11) | 1–4 | AS Chavanay (7) |
| 54. | Espérance Hostunoise (10) | 1–2 | FC Vaulx-en-Velin (5) |
| 55. | RC Mauves (10) | 3–4 | US Davézieux-Vidalon (10) |
| 56. | US Bas-Vivarais (11) | 0–0 (4–3 p) | Olympique de Valence (6) |
| 57. | UMS Montélimar (7) | 0–1 | FC Rhône Vallées (6) |
| 58. | AS Vallée du Doux (11) | 2–7 | FC Chabeuil (7) |
| 59. | FC Bren (12) | 2–2 (3–2 p) | FC Muzolais (10) |
| 60. | FC Hermitage (11) | 2–2 (2–4 p) | ES Beaumonteleger (11) |
| 61. | Vallis Auréa Foot (11) | 2–3 | CO Châteauneuvois (9) |
| 62. | FC Aubenas (11) | 1–2 | AL Saint-Maurice-l'Exil (9) |
| 63. | AS Véore Montoison (10) | 3–2 | US Rochemaure (11) |
| 64. | US Lussas (12) | 0–8 | AS Sud Ardèche (7) |
| 65. | ABH FC (12) | 0–6 | Hauts Lyonnais (5) |
| 66. | FC Loire Sornin (10) | 4–2 | FC Saint-Étienne (8) |
| 67. | FCI Saint-Romain-le-Puy (10) | 3–0 | Olympique Saint-Étienne (11) |
| 68. | US Métare Saint-Étienne Sud Est (11) | 0–3 | L'Étrat-La Tour Sportif (8) |
| 69. | US Filerin (11) | 0–8 | US Feurs (6) |
| 70. | CAS Cheminots Oullins Lyon (10) | 0–1 | Côte Chaude Sportif (7) |
| 71. | US Villerest (10) | 1–1 (4–5 p) | Sorbiers-La Talaudière (8) |
| 72. | AS Chambéon-Magneux (9) | 2–1 | CO Saint-Fons (9) |
| 73. | AS Saint-Just-Saint-Rambert (10) | 2–0 | FCO Firminy-Insersport (6) |
| 74. | AS Saint-Forgeux (10) | 0–2 | Stade Amplepuisien (8) |
| 75. | CS Crémeaux (10) | 1–1 (7–8 p) | ES Veauche (7) |
| 76. | Olympique Est Roannais (11) | 2–2 (4–3 p) | CS Meginand (9) |
| 77. | Saint-Chamond Foot (7) | 5–1 | US Saint-Galmier-Chambœuf (8) |
| 78. | FC Belette de Saint-Léger (13) | 2–2 (3–2 p) | FC Sourcieux-les-Mines (11) |
| 79. | US Parigny Saint-Cyr (11) | 4–5 | US Loire-Saint-Romain (10) |
| 80. | Roannais Foot 42 (7) | 0–3 | FC Roche-Saint-Genest (7) |
| 81. | AS Saint-Martin-en-Haut (9) | 1–3 | Forez Donzy FC (9) |
| 82. | US Formans (12) | 2–3 | Ambérieu FC (9) |
| 83. | Olympique Saint-Genis-Laval (7) | 1–2 | AS Bron Grand Lyon (8) |
| 84. | FC Gerland Lyon (10) | 1–0 | AS Bellecour-Perrache (8) |
| 85. | FC Varèze (8) | 2–0 | FC Sévenne (9) |
| 86. | US Villette-d'Anthon-Janneyrais (13) | 0–14 | FC Limonest Saint-Didier (5) |
| 87. | AS Genay (11) | 0–7 | AS Misérieux-Trévoux (6) |
| 88. | ASF Portugais (11) | 1–0 | Beaujolais Football (10) |
| 89. | AS Montchat Lyon (7) | 3–0 | Sud Lyonnais Foot (7) |
| 90. | FC Rive Droite (10) | 2–2 (2–3 p) | FC Chaponnay-Marennes (8) |
| 91. | Association Chandieu-Heyrieux (9) | 1–3 | CS Neuville (7) |
| 92. | US Millery-Vourles (8) | 0–2 | FC Saint-Cyr Collonges au Mont d'Or (8) |
| 93. | US Vaux-en-Bugey (12) | 1–5 | FC Veyle Sâone (8) |
| 94. | Valserine FC (11) | 3–0 | ES Revermontoise (10) |
| 95. | Échenevex-Ségny-Chevry Olympique (10) | 0–0 (5–4 p) | FC Mont Brouilly (9) |
| 96. | FC Dombes (10) | 1–4 | US Feillens (7) |
| 97. | FC Dombes-Bresse (9) | – | AS Portugaise Vaulx-en-Velin (10) |
| 98. | Olympique Saint-Marcellin (7) | 1–1 (5–4 p) | CS Viriat (8) |
| 99. | FC Colombier-Satolas (9) | 1–0 | ÉS Trinité Lyon (7) |
| 100. | FC Bressans (8) | 0–2 | Vénissieux FC (6) |
| 101. | CS Lagnieu (8) | 1–2 | Ain Sud Foot (5) |
| 102. | FC Bords de Saône (7) | 1–0 | FC Lyon (6) |
| 103. | AS Villeurbanne Éveil Lyonnais (9) | 1–0 | FC Croix Roussien (10) |
| 104. | FC Charvieu-Chavagneux (8) | 2–0 | SC Portes de l'Ain (9) |
| 105. | FC Échirolles (6) | 1–1 (6–5 p) | AC Seyssinet (6) |
| 106. | FC Vallée de l'Hien (11) | 2–5 | FC Vallée de la Gresse (8) |
| 107. | JS Chambéry (8) | 5–0 | AS Ugine (9) |
| 108. | Sporting Nord-Isère (8) | 4–1 | AS Italienne Européenne Grenoble (9) |
| 109. | ES Manival (7) | 2–5 | Chassieu Décines FC (6) |
| 110. | CO Chavanod (10) | 2–3 | Rives SF (10) |
| 111. | ES Rachais (8) | 0–0 (5–4 p) | Olympique Salaise Rhodia (6) |
| 112. | Noyarey FC (10) | 2–1 | FC Seyssins (8) |
| 113. | FC La Tour-Saint-Clair (7) | 2–0 | AS Domarin (8) |
| 114. | Nivolet FC (8) | 2–0 | US Jarrie-Champ (9) |
| 115. | Artas Charantonnay FC (10) | 1–2 | Vallée du Guiers FC (8) |
| 116. | AS Fontaine (12) | 0–10 | FC Bourgoin-Jallieu (5) |
| 117. | US Abbaye (13) | 0–3 | FC Belle Étoile Mercury (9) |
| 118. | US Ruy Montceau (10) | 3–1 | JS Saint-Georgeoise (11) |
| 119. | FC Laissaud (10) | 9–1 | AS Diémoz (10) |
| 120. | Moirans FC (12) | 2–4 | FC Crolles-Bernin (9) |
| 121. | MOS Trois Rivières (7) | 4–0 | US Arbent Marchon (8) |
| 122. | US La Ravoire (9) | 0–1 | US Gières (7) |
| 123. | Olympique Sud Revermont 01 (10) | 1–8 | Entente Val d'Hyères (8) |
| 124. | JS Reignier (9) | 1–2 | ES Bressane Marboz (7) |
| 125. | Haut Giffre FC (9) | 2–2 (5–4 p) | Marignier Sports (9) |
| 126. | FC Aravis (13) | 1–4 | ES Cernex (10) |
| 127. | AJ Ville-la-Grand (10) | 3–2 | US Pringy (8) |
| 128. | AG Bons-en-Chablais (10) | 2–3 | FC Foron (8) |
| 129. | ES Saint-Jeoire-La Tour (10) | 2–0 | FC Frangy (11) |
| 130. | AS Sillingy (9) | 4–1 | ASC Sallanches (10) |
| 131. | US Argonay (10) | 1–5 | US Annecy-le-Vieux (7) |
| 132. | ES Fillinges (10) | 0–5 | ES Tarentaise (7) |
| 133. | Oyonnax Plastics Vallée FC (8) | 4–2 | FC Chambotte (8) |
| 134. | US Annemasse-Gaillard (8) | 5–3 | AS Montréal-la-Cluse (9) |
| 135. | Chambéry SF (5) | 3–1 | Aix-les-Bains FC (6) |
| 136. | Thonon Évian FC (5) | 2–1 | Cluses-Scionzier FC (6) |
| 137. | ES Drumettaz-Mouxy (8) | 1–1 (5–4 p) | CS Amphion Publier (8) |
| 138. | FC La Filière (10) | 3–0 | FC Saint-Michel Sports (11) |
* ↑ Tie reversed from original draw.
* ↑ Match abandoned. Both sides penalised. No further information available.

### Fourth round

These matches were played on 2 and 3 October 2021.
Fourth round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | RC Charbonnières-Paugnat (10) | 2–2 (2–3 p) | AS Sansacoise (8) |
| 2. | US Issoire (7) | 0–2 | FC Chamalières (4) |
| 3. | ES Pierrefortaise (8) | 2–3 | Entente Nord Lozère (7) |
| 4. | US Gerzat (9) | 1–2 | Sporting Chataigneraie Cantal (6) |
| 5. | ES Couze Pavin (11) | 1–4 | ES Saint-Mamet (9) |
| 6. | Clermont Outre-Mer (10) | 0–7 | AS Saint-Jacques (6) |
| 7. | US Beaumontoise (7) | 3–2 | Aurillac FC (5) |
| 8. | Espérance Ceyratois Football (8) | 0–3 | US Saint-Flour (6) |
| 9. | FA Le Cendre (6) | 4–0 | US Brioude (7) |
| 10. | US Davézieux-Vidalon (10) | 0–4 | Côte Chaude Sportif (7) |
| 11. | Football Mont-Pilat (9) | 2–0 | FC Annonay (8) |
| 12. | SA Thiers (6) | 3–1 | AS Emblavez-Vorey (7) |
| 13. | AS Chadrac (8) | 5–0 | AS Loudes (8) |
| 14. | AF Pays de Coise (9) | 0–2 | Velay FC (5) |
| 15. | FC Espaly (6) | 0–0 (2–4 p) | AS Chavanay (7) |
| 16. | JS Cellieu (10) | 0–4 | US Blavozy (6) |
| 17. | SS Ussonaise (11) | 0–2 | Le Puy Foot 43 Auvergne (4) |
| 18. | Lempdes Sport (6) | 2–2 (3–4 p) | FC Roche-Saint-Genest (7) |
| 19. | AS Job (9) | 1–3 | Moulins Yzeure Foot (4) |
| 20. | SC Billom (9) | 0–4 | RC Vichy (6) |
| 21. | US Mozac (8) | 2–2 (4–2 p) | FC Nord Limagne (9) |
| 22. | AS Nord Vignoble (8) | 0–2 | FC Riom (6) |
| 23. | JS Neuvy (9) | 1–5 | Montluçon Football (5) |
| 24. | US Les Martres-de-Veyre (8) | 7–1 | FCUS Ambert (7) |
| 25. | CS Volvic (6) | 0–0 (4–5 p) | FC Cournon-d'Auvergne (7) |
| 26. | AS Domerat (6) | 2–3 | AA Lapalisse (7) |
| 27. | FC Souvigny (10) | 0–4 | AS Moulins (5) |
| 28. | L'Étrat-La Tour Sportif (8) | 2–0 | AS Sud Ardèche (7) |
| 29. | FC Bren (12) | 1–1 (2–4 p) | FC Chaponnay-Marennes (8) |
| 30. | US Pont-La Roche (11) | 1–1 (2–3 p) | AL Saint-Maurice-l'Exil (9) |
| 31. | US Reventin (9) | 1–3 | FCI Saint-Romain-le-Puy (10) |
| 32. | FC Belette de Saint-Léger (13) | 0–3 | AS Chambéon-Magneux (9) |
| 33. | AS Saint-Just-Saint-Rambert (10) | 1–5 | US Feurs (6) |
| 34. | Sorbiers-La Talaudière (8) | 0–2 | Andrézieux-Bouthéon FC (4) |
| 35. | US Saint-Gervais-sur-Roubion (11) | 0–4 | FC Limonest Saint-Didier (5) |
| 36. | ASF Pierrelatte (8) | 2–3 | Forez Donzy FC (9) |
| 37. | ES Veauche (7) | 0–2 | Entente Crest-Aouste (7) |
| 38. | FC Varèze (8) | 1–0 | Chassieu Décines FC (6) |
| 39. | FC Loire Sornin (10) | 0–5 | AS Montchat Lyon (7) |
| 40. | ES Beaumonteleger (11) | 0–0 (4–5 p) | AS Véore Montoison (10) |
| 41. | CO Châteauneuvois (9) | 0–5 | Lyon La Duchère (4) |
| 42. | FC Chabeuil (7) | 1–4 | Saint-Chamond Foot (7) |
| 43. | CS Neuville (7) | 5–1 | Sporting Nord-Isère (8) |
| 44. | MOS Trois Rivières (7) | 1–4 | Ain Sud Foot (5) |
| 45. | Olympique Est Roannais (11) | 1–12 | FC Bourgoin-Jallieu (5) |
| 46. | US Bas-Vivarais (11) | 0–3 | Vénissieux FC (6) |
| 47. | US Loire-Saint-Romain (10) | 0–3 | FC Rhône Vallées (6) |
| 48. | US Feillens (7) | 2–2 (6–7 p) | Stade Amplepuisien (8) |
| 49. | AS Villeurbanne Éveil Lyonnais (9) | 3–1 | FC Gerland Lyon (10) |
| 50. | FC Bords de Saône (7) | 0–2 | Hauts Lyonnais (5) |
| 51. | FC Colombier-Satolas (9) | 0–2 | FC Vaulx-en-Velin (5) |
| 52. | US Gières (7) | 2–1 | AS Bron Grand Lyon (8) |
| 53. | FC Saint-Cyr Collonges au Mont d'Or (8) | 1–1 (4–2 p) | FC Charvieu-Chavagneux (8) |
| 54. | winner match 97 | – | AS Misérieux-Trévoux (6) |
| 55. | FC Veyle Sâone (8) | 0–3 | GOAL FC (4) |
| 56. | FC Échirolles (6) | 1–1 (4–5 p) | AS Saint-Priest (4) |
| 57. | FC Vallée de la Gresse (8) | 0–1 | FC La Tour-Saint-Clair (7) |
| 58. | Noyarey FC (10) | 1–1 (5–3 p) | ASF Portugais (11) |
| 59. | Ambérieu FC (9) | 2–3 | US Ruy Montceau (10) |
| 60. | ES Bressane Marboz (7) | 2–1 | Nivolet FC (8) |
| 61. | Entente Val d'Hyères (8) | 2–1 | Olympique Saint-Marcellin (7) |
| 62. | Rives SF (10) | 1–2 | FC Crolles-Bernin (9) |
| 63. | FC Laissaud (10) | 1–1 (4–5 p) | ES Rachais (8) |
| 64. | JS Chambéry (8) | 1–2 | Chambéry SF (5) |
| 65. | Échenevex-Ségny-Chevry Olympique (10) | 2–2 (5–4 p) | AJ Ville-la-Grand (10) |
| 66. | FC La Filière (10) | 1–3 | Haut Giffre FC (9) |
| 67. | US Annecy-le-Vieux (7) | 0–0 (2–3 p) | Vallée du Guiers FC (8) |
| 68. | FC Belle Étoile Mercury (9) | 2–1 | Oyonnax Plastics Vallée FC (8) |
| 69. | ES Tarentaise (7) | 3–1 | ES Drumettaz-Mouxy (8) |
| 70. | FC Foron (8) | 1–1 (4–5 p) | AS Sillingy (9) |
| 71. | Thonon Évian FC (5) | 1–3 | GFA Rumilly-Vallières (4) |
| 72. | Valserine FC (11) | 1–1 (4–5 p) | US Annemasse-Gaillard (8) |
| 73. | ES Cernex (10) | 4–3 | ES Saint-Jeoire-La Tour (10) |
* ↑ AS Misérieux-Trévoux awarded a bye due to the outcome of the previous round.

### Fifth round

These matches were played on 16 and 17 October 2021.
Fifth round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | Entente Nord Lozère (7) | 1–1 (3–4 p) | FA Le Cendre (6) |
| 2. | FC Cournon-d'Auvergne (7) | 2–3 | Moulins Yzeure Foot (4) |
| 3. | Sporting Chataigneraie Cantal (6) | 1–1 (0–3 p) | RC Vichy (6) |
| 4. | AA Lapalisse (7) | 2–3 | US Beaumontoise (7) |
| 5. | AS Sansacoise (8) | 1–2 | US Saint-Flour (6) |
| 6. | AS Saint-Jacques (6) | 0–3 | FC Chamalières (4) |
| 7. | ES Saint-Mamet (9) | 1–1 (4–2 p) | US Les Martres-de-Veyre (8) |
| 8. | US Mozac (8) | 2–4 | Montluçon Football (5) |
| 9. | AS Moulins (5) | 3–1 | Velay FC (5) |
| 10. | FC Riom (6) | 0–2 | Le Puy Foot 43 Auvergne (4) |
| 11. | Entente Crest-Aouste (7) | 0–0 (13–12 p) | GOAL FC (4) |
| 12. | AS Chavanay (7) | 0–5 | FC Limonest Saint-Didier (5) |
| 13. | AL Saint-Maurice-l'Exil (9) | 0–7 | FC Villefranche (3) |
| 14. | Forez Donzy FC (9) | 1–1 (3–1 p) | Football Mont-Pilat (9) |
| 15. | AS Chadrac (8) | 1–2 | US Blavozy (6) |
| 16. | L'Étrat-La Tour Sportif (8) | 0–2 | Andrézieux-Bouthéon FC (4) |
| 17. | AS Véore Montoison (10) | 0–6 | Hauts Lyonnais (5) |
| 18. | Côte Chaude Sportif (7) | 0–0 (5–4 p) | FC Rhône Vallées (6) |
| 19. | FCI Saint-Romain-le-Puy (10) | 0–4 | Stade Amplepuisien (8) |
| 20. | Saint-Chamond Foot (7) | 0–0 (5–4 p) | ES Rachais (8) |
| 21. | FC Crolles-Bernin (9) | 0–1 | AS Villeurbanne Éveil Lyonnais (9) |
| 22. | US Ruy Montceau (10) | 1–10 | FC Bourgoin-Jallieu (5) |
| 23. | FC Chaponnay-Marennes (8) | 0–2 | FC Saint-Cyr Collonges au Mont d'Or (8) |
| 24. | FC Roche-Saint-Genest (7) | 2–1 | US Feurs (6) |
| 25. | SA Thiers (6) | 1–3 | Lyon La Duchère (4) |
| 26. | AS Saint-Priest (4) | 2–3 | Football Bourg-en-Bresse Péronnas 01 (3) |
| 27. | AS Chambéon-Magneux (9) | 0–6 | AS Montchat Lyon (7) |
| 28. | CS Neuville (7) | 2–2 (7–6 p) | FC Varèze (8) |
| 29. | Noyarey FC (10) | 0–5 | FC Vaulx-en-Velin (5) |
| 30. | ES Tarentaise (7) | 1–0 | US Gières (7) |
| 31. | FC Belle Étoile Mercury (9) | 1–1 (2–4 p) | AS Misérieux-Trévoux (6) |
| 32. | GFA Rumilly-Vallières (4) | 3–2 | FC Annecy (3) |
| 33. | ES Cernex (10) | 0–3 | Chambéry SF (5) |
| 34. | Échenevex-Ségny-Chevry Olympique (10) | 2–4 | FC La Tour-Saint-Clair (7) |
| 35. | US Annemasse-Gaillard (8) | 2–6 | Vénissieux FC (6) |
| 36. | Haut Giffre FC (9) | 1–1 (1–3 p) | ES Bressane Marboz (7) |
| 37. | Vallée du Guiers FC (8) | 1–2 | AS Sillingy (9) |
| 38. | Entente Val d'Hyères (8) | 0–2 | Ain Sud Foot (5) |

### Sixth round

These matches were played on 30 and 31 October 2021.
Sixth round results: Auvergne-Rhône-Alpes :
| Tie no | Home team (tier) | Score | Away team (tier) |
| 1. | FC Roche-Saint-Genest (7) | 1–1 (4–5 p) | Hauts Lyonnais (5) |
| 2. | ES Saint-Mamet (9) | 0–6 | FC Villefranche (3) |
| 3. | US Saint-Flour (6) | 1–4 | Le Puy Foot 43 Auvergne (4) |
| 4. | Côte Chaude Sportif (7) | 1–0 | AS Moulins (5) |
| 5. | Forez Donzy FC (9) | 1–2 | RC Vichy (6) |
| 6. | US Beaumontoise (7) | 0–2 | Montluçon Football (5) |
| 7. | Stade Amplepuisien (8) | 1–1 (2–4 p) | FC Limonest Saint-Didier (5) |
| 8. | US Blavozy (6) | 1–0 | FA Le Cendre (6) |
| 9. | FC Chamalières (4) | 0–1 | Moulins Yzeure Foot (4) |
| 10. | FC Saint-Cyr Collonges au Mont d'Or (8) | 2–2 (3–0 p) | Entente Crest-Aouste (7) |
| 11. | AS Sillingy (9) | 1–4 | Ain Sud Foot (5) |
| 12. | AS Villeurbanne Éveil Lyonnais (9) | 0–1 | Vénissieux FC (6) |
| 13. | CS Neuville (7) | 1–0 | FC Vaulx-en-Velin (5) |
| 14. | FC La Tour-Saint-Clair (7) | 1–6 | Lyon La Duchère (4) |
| 15. | AS Montchat Lyon (7) | 4–0 | AS Misérieux-Trévoux (6) |
| 16. | ES Bressane Marboz (7) | 0–2 | Andrézieux-Bouthéon FC (4) |
| 17. | Chambéry SF (5) | 1–0 | GFA Rumilly-Vallières (4) |
| 18. | ES Tarentaise (7) | 1–2 | FC Bourgoin-Jallieu (5) |
| 19. | Saint-Chamond Foot (7) | 2–2 (8–9 p) | Football Bourg-en-Bresse Péronnas 01 (3) |