OpenLLM-France/wikimedia huggingface dataset:
# Mitotane

Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. It is a derivative of the early insecticide DDT and an isomer of p,p'-DDDTooltip dichlorodiphenyldichloroethane (4,4'-dichlorodiphenyldichloroethane) and is also known as 2,4'-(dichlorodiphenyl)-2,2-dichloroethane (o,p'-DDD).

## Medical uses

Mitotane has been produced by Bristol Myers Squibb but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in need of it. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. In a 2007 retrospective study of 177 patients from 1985 to 2005 showed a significant increase in the recurrence-free interval after radical surgery followed by mitotane when compared to surgery alone. The drug is also sometimes used in the treatment of Cushing's syndrome.

## Side effects

The use of mitotane is unfortunately limited by side effects, which, as reported by Schteingart et al., include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%).

## Pharmacology
### Pharmacodynamics

Mitotane is an inhibitor of the adrenal cortex. It acts as an inhibitor of cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), and also of 11β-hydroxylase (CYP11B1), 18-hydroxylase (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent. In addition, mitotane has direct and selective cytotoxic effects on the adrenal cortex, via an unknown mechanism, and thereby induces permanent adrenal atrophy similarly to DDD.

## Chemistry

Analogues of mitotane include aminoglutethimide, amphenone B, and metyrapone.

## History

Mitotane was introduced in 1960 for the treatment of adrenocortical carcinoma.

## Society and culture
### Generic names

Mitotane is the generic name of the medication and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name, and JANTooltip Japanese Accepted Name.

### Brand names

Mitotane is sold under the brand name Lysodren.

## Veterinary use

Mitotane is also used to treat Cushing's disease (pituitary-dependent Cushing's syndrome) in dogs. The medication is used in the controlled destruction of adrenal tissue, leading to a decrease in cortisol production.
# Capay Hills

The Capay Hills are a low mountain range of the Inner Northern California Coast Ranges System, in Yolo County, California.
They are located on the western side of the Sacramento Valley.
The Capay Valley and Capay Valley AVA are west of the hills.
# Muirpur Airport

Muirpur Airport also spelled as Myorpur Airport is an upcoming airport, situated at Myorpur approx 12 km (7.5 mi) from the Renukut in the Sonbhadra district in the Indian state of Uttar Pradesh. Airport is developing by upgrading the existing government airstrip. It serves nearby towns, Northern Coalfields Limited (NCL) (coal fields), NTPC projects Renukut and Robertsganj, the Other towns of Sonbhadra and Singrauli district of Madhya Pradesh. Balrampur-Ramanujganj district of Chhattisgarh and Garhwa district of Jharkhand. The airport serves the region which has many electrical power stations, known as the "Energy Capital of India". It is 26.5 km (16.5 mi) away from DUDHI TEHSIL. The proposed airport will boost the power sector of the nation and more investment will be made in the power sector internationally. This Airport will be connected to a nearby railway and bus station.

## Destinations

Domestic proposed flights will directly operate from Lucknow.

## Communities served

* OYNEERAJ OPC PVT LTD
* Rihandnagar NTPC
* Shaktinagar NTPC
* Vindhyanagar NTPC
* Anpara UPRVUNL
* Obra UPRVUNL
* Renusagar UPRVUNL
* Pipri UPRVUNL
* Singrauli
* Renusagar Hindalco
* Finiva Group Of Company
* Finiva Nidhi Limited
* Finiva Financial Limited
* Finiva Tech Limited
* Finiva Retail Limited
* Dalla Dalla Cement Factory etc.
# Edward Knatchbull-Hugessen

Edward Knatchbull-Hugessen may refer to:
* Edward Knatchbull-Hugessen, 1st Baron Brabourne (1829–1893), British politician
* Edward Knatchbull-Hugessen, 2nd Baron Brabourne (1857–1909), British politician
# Robert Ian Aonas MacInnes

Robert Ian Aonas MacInnes QC (23 July 1902 – 14 January 1972), was Sheriff of Lanarkshire and a Scottish Liberal Party and Scottish Labour Party politician.

## Background

MacInnes was born the younger son of Rev. Dr Alexander MacInnes, Kirkliston, of Edinburgh. He was educated at the University of Edinburgh. In 1937 he married Mary Galloway Morrison and together they had one daughter.

## Professional career

MacInnes was called to Scottish Bar in 1924. He was Sheriff Substitute of Ross and Cromarty and Sutherland at Stornoway 1934–40, of Argyll at Dunoon 1940–41, of Bute at Rothesay 1940–41 and of Lanarkshire at Glasgow 1948–53. He was made a Queen's Counsel (Scotland) in 1946. He was Sheriff Substitute of Lanarkshire at Hamilton from 1953–55.

## Political career

MacInnes was Liberal candidate for the West Stirlingshire division at the 1923 General Election. He was Labour candidate for the Caithness and Sutherland division at the 1945 General Election. He did not stand for parliament again.

### Electoral record

General Election 1923: Stirlingshire West :
| Party | Party | Candidate | Votes | % | ±% |
| | Labour | Thomas Johnston | 9,242 | 51.9 | −0.5 |
| | Unionist | Harry Hope | 6,182 | 34.7 | −12.9 |
| | Liberal | Robert Ian Aonas MacInnes | 2,390 | 13.4 | n/a |
| Majority | Majority | Majority | 3,060 | 17.2 | +12.4 |
| Turnout | Turnout | Turnout | | 74.7 | +0.6 |
| | Labour hold | Labour hold | Swing | +6.2 | |
General Election 1945: Caithness and Sutherland :
| Party | Party | Candidate | Votes | % | ±% |
| | Unionist | Eric Gandar Dower | 5,564 | 33.5 | n/a |
| | Labour | Robert Ian Aonas MacInnes | 5,558 | 33.4 | n/a |
| | Liberal | Archibald Henry Macdonald Sinclair | 5,503 | 33.1 | −39.2 |
| Majority | Majority | Majority | 6 | 0.0 | |
| Turnout | Turnout | Turnout | | 64.2 | +4.1 |
| | Unionist gain from Liberal | Unionist gain from Liberal | Swing | n/a | |
# Port Hedland Saltworks Important Bird Area

The Port Hedland Saltworks Important Bird Area is a 103 km$^2$ tract of originally intertidal land, now containing a saltern, lying about 20 km east of the port of Port Hedland on the coast of the Pilbara region of north-west Western Australia. The salt processing facility is operated by Dampier Salt Ltd, part of the Rio Tinto Group.

## Description

The Important Bird Area (IBA) comprises a system of evaporation ponds, the intake zone where seawater enters, and the adjacent intertidal mudflats. The system includes levee banks and scattered mangroves. During low tides, waterbirds forage on the mudflats and along nearby creeks. During high tides, they move to the saltworks to continue feeding or to roost.

### Port Hedland Saltworks

The Port Hedland Saltworks was purchased by Dampier Salt in 2001 and covers an operational area of about 91 km$^2$ of which the nine evaporation ponds take up 78 km$^2$. It has an annual production capacity of 3.2 Mt.

### Birds

The site has been identified by BirdLife International as an IBA because it regularly supports over 1% of the world populations of red-necked stints and sharp-tailed sandpipers, as well as a population of the range-restricted dusky gerygone. It previously supported much greater numbers of several more species of waterbirds, especially waders, with counts of up to 66,800 birds present; however, since the expansion of the saltworks in the 1990s numbers have dropped to 5000–10,000. Species that have strongly declined since the 1980s are broad-billed sandpipers, Asian dowitchers, curlew sandpipers, red-necked avocets, banded stilts, Oriental plovers, Oriental pratincoles and white-winged black terns. Other species present include Australian bustards, bush stone-curlews, western bowerbirds, painted finches and canary white-eyes.
# Priestley

Priestley may refer to:

## Places

* Priestley, West Virginia, US, an unincorporated community
* Priestley Glacier, a major valley glacier in Antarctica
* Priestley (lunar crater), on the far side of the Moon
* Priestley (Martian crater)
* 5577 Priestley, an inner main belt asteroid

## People
### Arts

* Alice Priestley (born 1962), Canadian children's writer and illustrator
* Bel Priestley (born 2003), English actress and internet personality
* Brian Priestley (born 1940), English jazz writer, pianist and arranger
* Joanna Priestley (born 1950), American film director and animator
* Chris Priestley (born 1958), British children's book author and illustrator
* Jason Priestley (born 1969), Canadian-American actor
* J. B. Priestley (1894–1984), English writer and broadcaster
* Mark Priestley (1976–2008), Australian actor
* Rick Priestley (born 1959), British miniature wargame designer and author
* Robert Priestley (1901–1986), American set decorator
* Tom Priestley (born 1932), sound and film editor

### Sciences

* Henry Priestley (biochemist) (1884–1961), Australian biochemist
* Hilary Priestley, British mathematician
* James Taggart Priestley (1903–1979), American surgeon
* John Gillies Priestley (1879–1941), British physiologist
* Joseph Hubert Priestley (1883–1944), British botanist
* Joseph Priestley (1733–1804), British theologian, dissenting clergyman, natural philosopher, chemist, educator, and political theorist
* Maurice Priestley (1933–2013), emeritus professor of statistics at the University of Manchester
* Raymond Priestley (1886–1974), British geologist and Antarctic explorer

### Sports

* Adam Priestley (born 1990), Gibraltarian footballer
* Akeem Priestley (born 1985), Jamaican footballer
* Dennis Priestley (born 1950), English darts player
* Donald Priestley (1887–1917), English cricketer
* Gerry Priestley (1931–2020), English footballer
* John Priestley (footballer) (1900–1980), Scottish footballer
* Neil Priestley (born 1961), English cricketer
* Robert Priestley (1911–2007), English cricketer
* Tommy Priestley (1911–1985), Northern Irish footballer

### Other

* Arthur Priestley (1865–1933), English Liberal Party politician and cricketer
* Briggs Priestley (1831–1907), English cloth manufacturer and Liberal Party politician
* Julian Priestley (1950–2017), Secretary-General of the European Parliament 1997–2007
* Mary Priestley (1925–2017), British music therapist
* Monique Priestley, American politician from Vermont
* Philip Priestley (1946–2022), British diplomat

## Other uses

* Priestley College, a sixth-form college
* The Priestley, a proscenium theatre
* Dr. Priestley, a fictional investigator
# Delias pratti

Delias pratti is a species of butterfly in the family Pieridae. The type was described by George Hamilton Kenrick in 1909. It is found in Papua New Guinea, the type location is the Foja Mountains.
The wingspan is about 50 mm. The forewings and hindwings are black, the forewings are without markings and the hindwings have an inner white area between the cell and inner margin and between the base and outer margin to vein four.
# Cation-dependent mannose-6-phosphate receptor

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.
The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes.

## Structure

The CD-MPR is a type I transmembrane protein (that is, it has a single transmembrane domain with its C-termini on the cytoplasmic side of lipid membranes) with a relatively short cytoplasmic tail. The extracytoplasmic/lumenal M6P binding-domain consists of 157 amino acid residues. The CD-MPR is approximately 46 kDa in size and it both exists and functions as a dimer.
The cell surface receptor for insulin-like growth factor 2 also functions as a cation-independent mannose 6-phosphate receptor. It consists of fifteen repeats homologous to the 157-residue CD-M6PR domain, two of which are responsible for binding to M6P.

## Function

Both CD-MPRs and CI-MPRs are lectins that bind their M6P-tagged cargo in the lumen of the Golgi apparatus. The CD-MPR shows greatly enhanced binding to M6P in the presence of divalent cations, such as manganese. The MPRs (bound to their cargo) are recognized by the GGA family of clathrin adaptor proteins and accumulate in forming clathrin-coated vesicles. They are trafficked to the early endosome where, in the relatively low pH environment of the endosome, the MPRs release their cargo. The MPRs are recycled back to the Golgi, again by way of interaction with GGAs and vesicles. The cargo proteins are then trafficked to the lysosome via the late endosome independently of the MPRs.
# Santa Maria della Misericordia, Bologna

Santa Maria della Misericordia is a Renaissance-style Roman Catholic church located on Piazza di Porta Castiglione #4 in Bologna, region of Emilia Romagna, Italy. It stands adjacent to the Giardini Margherita and Viale Giovanni Gozzadini.
A church at this site, outside of the city walls, was rebuilt in 1432 by the Olivetan order. The church was then acquired by an Augustinian order of Friars, who added the portico in the late 15th-century. The interior houses works by various important artists including a fresco (moved to canvas) depicting the Madonna dell'Umiltà (1397) by Lippo di Dalmasio. There are also works by Bartolommeo Ramenghi (il Bagnacavallo), Bartolomeo Cesi, Vincenzo Spisanelli, Ubaldo Gandolfi and Francesco Francia.
# Chavadipalayam railway station

Chavadipalayam railway station (station code: CVD) is an NSG–6 category Indian railway station in Salem railway division of Southern Railway zone. It is a station near Erode in Tamil Nadu, India. It is located along the Erode–Tiruchirappalli line between Erode Junction and Karur Junction.

## Goods terminal

A goods terminal has been developed by a private sector company in this station. It has a facility to serve goods traffic of half rake/full rake inward and outward goods from locals through booking.
# Kiridashi

Kiridashi may refer to:
* Kiridashi (knife), a Japanese knife
* Kiridashi (horse), a Canadian Thoroughbred racehorse
# Lebia subrugosa

Lebia subrugosa is a species of ground beetle in the family Carabidae. It is found in North America.
# Yard Movement

Yard Movement is an album by the Jamaican American musician Monty Alexander, released in 1996. Alexander supported the album with a UK tour that included Ernest Ranglin; Alexander also undertook a North American tour. With Ranglin's Below the Baseline, Yard Movement was the first album from Island Records' Island Jamaica Jazz label. The album peaked at No. 25 on the Official Jazz & Blues Albums Chart. Alexander subsequently formed a band he named Yard Movement.

## Production

Three songs were recorded at the 1995 Montreux Jazz Festival. "Exodus" is a combination of the "Theme of Exodus" with Bob Marley's "Exodus". Lennox "Boogsie" Sharpe played steelpan on "Crying". "Regulator" was inspired by Nat Adderley's "Work Song". Ernest Ranglin played lead guitar on Yard Movement.

## Critical reception

Professional ratings :
| Review scores ||
| Source | Rating |
| AllMusic | |
| The Guardian | |
| The Penguin Guide to Jazz on CD | |
The St. Louis Post-Dispatch wrote that "a technical bravado and engaging emotionalism mark the eight compositions of Yard Movement, Alexander favoring ripening glissandos to achieve his notable effects." The Guardian determined that Yard Movement "does capture much of the infectious appeal of his live shows, shows how effectively his improvising can avoid repetition when he's hot, and presents a crisp and energetic band." The South Wales Evening Post noted that the album "demonstrates his early musical influences and social experiences." The Houston Chronicle opined that Alexander "sounds like an herbally fortified cocktail pianist gone mad," and listed the album among the best of 1996.
AllMusic wrote: "Essentially smooth bop laid in over heavy reggae basslines, the tracks on Yard Movement ... work surprisingly well, grooving and shifting directions with a deceptive ease, and Ranglin's bright, bubbly guitar is a continual delight throughout."
# Cleptometopus similis

Cleptometopus similis is a species of beetle in the family Cerambycidae. It was described by Gahan in 1895.
# Delias periboea

Delias periboea is a butterfly in the family Pieridae. It was described by Jean-Baptiste Godart in 1819. It is found in both the Indomalayan realm and the Australasian realm; East and West of the Wallace line.

## Subspecies

* D. p. periboea (Java, Kangean Islands)
* D. p. alorensis Fruhstorfer, 1899 (Alor)
* D. p. floresiana Roepke, 1954 (Flores)
* D. p. livia Fruhstorfer, 1896 (Lombok)
* D. p. atakei Nakano, 1993 (Kangean)
* D. p. pagenstecheri Fruhstorfer, 1896 (Sumba)
* D. p. wallacei Rothschild, 1892 (Bali)
# Cation channel sperm-associated auxiliary subunit gamma

Cation channel sperm-associated auxiliary subunit gamma is a protein in humans encoded by the CATSPERG gene.
# Saposin protein domain

The saposin domains refers to two evolutionally-conserved protein domains found in saposin and related proteins (SAPLIP). Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes. They probably act by isolating the lipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after proteolytic cleavage, and two Saposin-A domains that are removed in the activation reaction.
The Saposin-B domains also occur in other proteins, most of them playing a role in interacting with membranes.

## Classification

The saposin (SapB1-SapB2) domains are found in a wide range of proteins. Each half-domain encodes two alpha helices in the SapB domain for a total of four.
The mamallian prosaposin (domain organization below) is a prototypic family member. It also includes the N- and C-terminal SapA domains, both of which are proteolyticly cleaved as the proprotein matures. Four connected pairs of SapB1-SapB2 domains are released, sequentially named Saposin-A through D. Some closely related proteins, such as PSAPL1 and SFTPB, share the architecture and the cleaving mechanism in whole or in part. While Prosaposin and PSAPL1 act in lysosomal lipid degradation, SFTPB is released into the pulmonary surfactant, playing a role in rearranging lipids.
However, proteins like GNLY and AOAH do not carry a SapA domain. While GNLY is essentially a SapB with N-terminal extensions specialized for lysing pathogen cell membranes, the ADAH protein uses the uncleaved SapB domain for targeting the correct intracellular compartment.
The plant-specific insert is an unusual variation on the SapB domains. It features a circular permutation compared to the usual topology: instead of featuring a SapB1-SapB2 unit, it is made up of a SapB2-linker-SapB1 unit seemingly derived by taking a half of each of two SapB units.

## Human proteins containing this domain

* AOAH
* GNLY
* Prosaposin
* PSAPL1
* SFTPB
# Darryl Haley

Darryl Haley (born February 16, 1961) is an American former professional football player who was an offensive lineman in the National Football League (NFL). He played college football for the Utah Utes before spending six seasons in the NFL with the New England Patriots, the Cleveland Browns, and the Green Bay Packers.
# Kiridashi (horse)

Kiridashi (foaled 1992 in Ontario) is a Canadian Thoroughbred racehorse.

## Background

He was bred, raced and trained by members of the Minshall family. Out of the mare, Sharp Briar, his sire was Canadian Horse Racing Hall of Fame inductee, Bold Ruckus. Grandsire Boldnesian was also the grandsire of the 1977 U.S. Triple Crown winner, Seattle Slew.

## Racing career
### 1994 Two-Year-Old season

For trainer Barbara Minshall, Kiridashi raced at age two, notably running second in the Kingarvie Stakes.

### 1995 Three-Year-Old season

At age three he ran a tired fourth to winner Regal Discovery in the Queen's Plate then won the second leg of the Canadian Triple Crown series, the Prince of Wales Stakes. For trainer Barbara Minshall, it marked the first time a woman saddled a winner of a Triple Crown race. Her accomplishment earned her a Sovereign Award nomination. Kirdashi's other 1995 win came in the Col. R.S. Mclaughlin Handicap.

### 1996: Four-Year-Old season

Racing at age four in 1996, Kiridashi's wins included the King Edward Breeders' Cup Handicap, the Fair Play Stakes, in which he set a Woodbine Racetrack track record of 1:40 4/5 for a mile and a sixteenth on dirt, and Vigil Handicap. As a five-year-old, Kiridashi won the first of his two Connaught Cup Stakes on turf, his second Vigil Handicap, and the Jacques Cartier Stakes. Kiridashi finished fourth to Da Hoss in the 1996 Breeders' Cup Mile, hosted that year by Woodbine Racetrack in Toronto.

## Stud career

Retired after his 1998 campaign, at stud, Kiridashi's best offspring was his millionaire daughter Financingavailable who was voted the 2006 and 2007 Sovereign Award for Champion Older Female Horse plus the 2007 Sovereign Award for Champion Sprinter.
# Edvaldo

Edvaldo is a given name. It may refer to:
* Edvaldo Alves de Santa Rosa (1934-2002), known as Dida, Brazilian football attacking midfielder
* Edvaldo Izidio Neto (1934-2002), known as Vavá, Brazilian football striker
* Edvaldo Oliveira (born 1963), Brazilian boxer
* Edvaldo Santos (born 1966), Brazilian weightlifter
* Edvaldo (footballer, born 1966), Edvaldo Teles Alves, Brazilian football forward
* Edvaldo (footballer, born 1974), Edvaldo Gonçalves Pereira, Brazilian football striker
* Edvaldo Valério (born 1978), Brazilian swimmer
* Edvaldo Gonzaga (born 1982), Brazilian boxer
* Edvaldo Ferreira (born 1990), Angolan handball player
# Dorcadion kapchagaicum

Dorcadion kapchagaicum is a species of beetle in the family Cerambycidae. It was described by Mikhail Leontievich Danilevsky in 1996. It is known from Kazakhstan.