# 2022 Challenger Ciudad de Guayaquil – Singles

Alejandro Tabilo was the defending champion but chose not to defend his title.
Daniel Altmaier won the title after defeating Federico Coria 6–2, 6–4 in the final.

## Seeds

* Federico Coria (final)
* Tomás Martín Etcheverry (first round)
* Daniel Altmaier (champion)
* Juan Pablo Varillas (semifinals)
* Juan Manuel Cerúndolo (second round)
* Franco Agamenone (second round)
* Santiago Rodríguez Taverna (first round)
* Felipe Meligeni Alves (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Federico Coria | 6 | 2 | 7$^7$ | | | | |
| 4 | Juan Pablo Varillas | 4 | 6 | 6$^4$ | | | | |
| 4 | Juan Pablo Varillas | 4 | 6 | 6$^4$ | 1 | Federico Coria | 2 | 4 |
| | | | | | 3 | Daniel Altmaier | 6 | 6 |
| 3 | Daniel Altmaier | 7$^7$ | 6 | | 3 | Daniel Altmaier | 6 | 6 |
| Q | Marco Cecchinato | 6$^4$ | 4 | | | | | |

### Top half

| First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | F Coria | 6 | 7$^8$ | | | | | | | | | | | | | | |
| | F Comesaña | 2 | 6$^6$ | 1 | F Coria | 3 | 6 | 7$^7$ | | | | | | | | | |
| Alt | N Milojević | 6$^1$ | 2 | | F Díaz Acosta | 6 | 1 | 6$^2$ | | | | | | | | | |
| | F Díaz Acosta | 7$^7$ | 6 | | | | | | 1 | F Coria | 6 | 6 | | | | | |
| Alt | N Sánchez Izquierdo | 1 | 6$^8$ | | | | | | | M Pucinelli de Almeida | 4 | 4 | | | | | |
| | M Pucinelli de Almeida | 6 | 7$^{10}$ | | M Pucinelli de Almeida | 6 | 6 | | | | | | | | | | |
| Q | Juan Ignacio Galarza | 4 | 6$^3$ | 8 | F Meligeni Alves | 3 | 4 | | | | | | | | | | |
| 8 | F Meligeni Alves | 6 | 7$^7$ | | | | | | | | | | 1 | F Coria | 6 | 2 | 7$^7$ |
| 4 | JP Varillas | 6 | 6 | | | | | | | | | | 4 | JP Varillas | 4 | 6 | 6$^4$ |
| Q | E Ribeiro | 2 | 1 | 4 | JP Varillas | 6 | 7$^7$ | | | | | | | | | | |
| WC | Á Guillén Meza | 6 | 6 | WC | A Guillén Meza | 1 | 6$^3$ | | | | | | | | | | |
| WC | A Andrade | 4 | 3 | | | | | | 4 | JP Varillas | 6 | 6 | | | | | |
| PR | S Nagal | 6 | 6 | | | | | | | N Kicker | 1 | 3 | | | | | |
| | D Dutra da Silva | 2 | 1 | PR | S Nagal | 1 | 6 | 5 | | | | | | | | | |
| | N Kicker | 6 | 6 | | N Kicker | 6 | 3 | 7 | | | | | | | | | |
| 7 | S Rodríguez Taverna | 1 | 4 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | F Agamenone | 7 | 6 | | | | | | | | | | | | | | | |
| WC | C March | 5 | 1 | | 6 | F Agamenone | 2 | 6 | 4 | | | | | | | | | |
| | H Casanova | 1 | 7$^7$ | 5 | | J de Jong | 6 | 4 | 6 | | | | | | | | | |
| | J de Jong | 6 | 6$^5$ | 7 | | | | | | | J de Jong | 2 | 6 | 3 | | | | |
| Alt | R Quiroz | 3 | 6$^2$ | | | | | | | 3 | D Altmaier | 6 | 3 | 6 | | | | |
| | JB Torres | 6 | 7$^7$ | | | JB Torres | 4 | 3 | | | | | | | | | | |
| Q | T Seyboth Wild | 6 | 6$^5$ | 2 | 3 | D Altmaier | 6 | 6 | | | | | | | | | | |
| 3 | D Altmaier | 1 | 7$^7$ | 6 | | | | | | | | | | | 3 | D Altmaier | 7$^7$ | 6 |
| 5 | JM Cerúndolo | 6 | 6 | | | | | | | | | | | | Q | M Cecchinato | 6$^4$ | 4 |
| | G Melzer | 4 | 2 | | 5 | JM Cerúndolo | 7$^7$ | 2 | 4 | | | | | | | | | |
| | TA Tirante | 3 | 6$^5$ | | Q | J Choinski | 6$^3$ | 6 | 6 | | | | | | | | | |
| Q | J Choinski | 6 | 7$^7$ | | | | | | | Q | J Choinski | 1 | 3 | | | | | |
| Q | M Cecchinato | 6 | 6 | | | | | | | Q | M Cecchinato | 6 | 6 | | | | | |
| Q | B Bicknell | 1 | 3 | | Q | M Cecchinato | 6 | 2 | | | | | | | | | | |
| LL | RA Burruchaga | 6$^3$ | 7 | 7 | LL | RA Burruchaga | 1 | 0$^r$ | | | | | | | | | | |
| 2 | TM Etcheverry | 7$^7$ | 5 | 5 | | | | | | | | | | | | | | |