OpenLLM-France/wikimedia huggingface dataset:
# L-655,708

L-655,708 (FG-8094) is a nootropic drug invented in 1996 by a team working for Merck, Sharp and Dohme, that was the first compound developed which acts as a subtype-selective inverse agonist at the α$_5$ subtype of the benzodiazepine binding site on the GABA$_A$ receptor. It acts as an inverse agonist at the α$_1$, α$_2$, α$_3$ and α$_5$ subtypes, but with much higher affinity for α$_5$, and unlike newer α$_5$ inverse agonists such as α$_5$IA, L-655,708 exerts its subtype selectivity purely via higher binding affinity for this receptor subtype, with its efficacy as an inverse agonist being around the same at all the subtypes it binds to.
A radiolabelled form of L-655,708 was used to map the distribution of the GABA$_A$ α$_5$ subtype in the brain, and it was found to be expressed predominantly in the hippocampus, an area of the brain involved with learning and memory. Activation of this subtype is thought to be largely responsible for producing the cognitive side effects displayed by many benzodiazepine and nonbenzodiazepine drugs, such as amnesia and difficulties with learning and memory, and so this led researchers to conclude that a drug acting as an inverse agonist at this subtype should have the opposite effect and enhance learning and memory.
L-655,708 was indeed found to produce improved cognitive performance in animal studies, without producing the side effect of convulsions which is produced by non-selective inverse agonists like DMCM. However it was found to be anxiogenic at doses which enhanced cognition, most likely because of its inverse agonist effects on other subtypes such as α$_2$ and α$_3$, making it unlikely that this drug would be suitable for use as a nootropic in humans. Still, L-655,708 may find use in the clinic to combat postoperative cognitive dysfunction since administration of sub-nootropic doses of L-655,708 prevented persistent memory impairment in mice anesthetized with isoflurane.
A study from 2015 found that L-655,708, and another α$_5$ subunit-containing GABA$_A$ receptor-selective negative allosteric modulator, MRK-016, produced rapid, ketamine-like antidepressant effects in animal models of depression.
# São Bartolomeu de Regatos

São Bartolomeu de Regatos is a parish in the municipality of Angra do Heroísmo on the island of Terceira in the Azores. The population in 2011 was 1,983, in an area of 25.00 km². The parish lies at an elevation of 22 metres. It contains the localities Calçada, Canada da Igreja, Carneiros, Cruz dos Regatos, Cova dos Regatos, Outeirão, Outeiro, Pesqueiro, Regatos, São Bartolomeu dos Regatos and São José.
# Source (photography magazine)

Source is a quarterly photography magazine published in Belfast. It is distributed throughout Ireland, Great Britain and internationally.

## History

Source was first published in 1992 as a newsletter of the organisation Photo Works North. This organisation had been set up the previous year to promote photography in Northern Ireland. The first editor was the photographer Paul Seawright.
From 1995 Source expanded its remit to include review coverage of exhibitions across Ireland and the UK. Since 2002 it has also included extensive reviews of photographic publishing. In 2007 Source published its 50th issue and was relaunched in a new format with additional columns and more review coverage.

## Coverage

Source is primarily concerned with social, historical or aesthetic uses of photography rather than technical or amateur photography. The magazine deals largely with art photography, in exhibition or book reviews, essays or in the portfolios of photographs it publishes. These portfolios are selected from submissions, including those from photographers who have attended the regular portfolio days the magazine has run at venues around Ireland and the UK since 1997.
However, as well as art photography the magazine is also concerned with other non-artistic uses of the medium and has in the past published essays on subjects such as police photography, pornography, satellite photographs, children's book illustration, copyright, photography and literature, and the history of photography. This approach is typified by two columns that have run since the magazine's relaunch in 2007, discussing photography in relation to 'advertising' and 'law'.

## Source website

Source has had a website since 1997. Since 2002 this has included a growing archive of all the back issue content of the magazine. Additionally it contains two projects that are specific to the website: oral history interviews and graduate photography online. The Source oral history archive consists of lengthy interviews with photographers, curators and writers about their lives and involvement in photography. These are gradually being made available as indexed audio files sometimes up to three hours in length. Graduate photography online, running since 2007 is a large gallery of the work of graduating photography students in Ireland and the UK with each student represented by a selection of their work indexed by the universities they have attended.
# Hidden 3D

Hidden 3D is an Italian-Canadian horror film directed by Antoine Thomas and produced by Caramel Films. It was filmed in Italy and Canada over the Summer and Fall of 2010. Hidden 3D was filmed in both 2D and 3D Technologies.

## Plot

When his mother dies, Brian Carter is surprised to learn that he has inherited The Sanctuary, home to her controversial experimental addiction treatment center. Having previously believed that the building burned to the ground years ago, Brian travels there with a group of friends and meets Haley, a mysterious friend of his mother, who acts as their guide through the impressive, monastery-like building. During their tour it becomes clear that something sinister lies beneath the surface.
Despite their misgivings, they follow a secret passageway underground and come across strange and unsettling discoveries that trigger Brian's disturbing memories of his mother's research. Ultimately, they are confronted by her terrible secret: Brian's mother built a revolutionary machine that cured people of their addictions but, as a side effect, those addictions materialized in the form of mutant children hungry for human flesh.
Sharing the dark bowels of the building with swarms of firefly-like creatures that they use to lure their victims into death traps, the mutant children begin a wild hunt, with the new visitors as their prey. Fighting to stay alive against the inconceivable, Brian and his friends soon realize that some things are better left hidden.

## Cast

* Devon Bostick as Lucas
* Jason Blicker as Simon
* Sean Clement as Brian Carter
* Bjanka Murgel as Kimberly
* Simonetta Solder as Haley Gable
* Jordan Hayes as Vicky
* Dawn Ford as Dr Susan Carter
* Elliott Larson as Haley's Son
* Cristina Rosato as Newsreporter
* Allan Kolman as Chester

## Release

The film was released on 21 April 2011, in the US and United Kingdom.
# Chlorociboria aeruginosa

Chlorociboria aeruginosa is a saprobic species of mushroom, commonly known as the green elfcup or the green wood cup because of its characteristic small, green, saucer-shaped fruit bodies (macroscopically identical to those of Chlorociboria aeruginascens, also described with those names). Although the actual fruit bodies are infrequently seen, the green staining of wood caused by the fungus is more prevalent.

## Description

This species has apothecia (cup-shaped ascocarps) that are usually attached laterally, often less than 0.5 cm in diameter, reaching 0.5-1 cm, collapsing laterally and becoming rolled inwards when dry. The outer tissue layer of the apothecium is bright green and smooth on the top, and felty and pale blue-green on the underside and stipe, darkening with age. The stipe is typically short, with a central or eccentric attachment to the apothecia. Spores are roughly spindle-shaped (fusiform), smooth, 9-14 x 2-4 μm. Spore print is white. Asci are eight-spored; typically 65 x 5 μm. Apothecia grow on bark-free wood, especially oak, beech and hazel, part of which at least is stained greenish by the mycelium.
The species is distinguished from the closely related C. aeruginascens by having bigger spores. Although some authors have in the past failed to recognize any appreciable differences between the two species, Ramamurthi and colleagues note that not only are the spore sizes different, but C. aeruginosa have roughened hyphae, in contrast with the smooth hyphae of C. aeruginascens.

## "Green oak"

Both C. aeruginosa and C. aeruginascens contain a quinone pigment called xylindein, a dimeric naphthoquinone derivative, whose structure was determined by spectroscopic means in the 1960s and later confirmed by X-ray crystallography. It is this compound that is responsible for the characteristic bluish-green stain of wood infected by thosespecies, used today in decorative woodworking such as Tunbridge ware and parquetry. The use of this wood, known as "green oak", goes back to 15th century Italy, where it was used in intarsia panels made by Fra Giovanni da Veroni.
# List of awards and nominations received by Smriti Irani

Smriti Irani is an Indian television actress, known for her portrayal as Tulsi Virani in Ekta Kapoor's production Kyunki Saas Bhi Kabhi Bahu Thi on Star Plus, for which she holds the record of winning five consecutive ITA Award for Best Actress Popular and four Indian Telly Awards.

## Indian Television Academy Awards

The Indian Television Academy Awards, also known as the (ITA Awards) is an annual event organised by the Indian Television Academy. The awards are presented in various categories, including popular programming (music, news, entertainment, sports, travel, lifestyle and fashion), best television channel in various categories, technical awards, and Best Performance awards.
| Year | Category | Show | Character | Result |
| 2001 | Best Actress (Popular) | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2002 | Best Actress (Popular) | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2003 | Best Actress (Popular) | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2004 | Best Actress (Popular) | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2005 | Best Actress (Popular) | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2010 | ITA Milestone Award | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |

## Indian Telly Awards

The 'Indian Telly Awards' are annual honours presented by the company of Indian Television to persons and organisations in the television industry of India. The Awards are given in several categories such as best programme or series in a specific genre, best television channel in a particular category, most popular actors and awards for technical roles such as writers and directors.
| Year | Category | Show | Character | Result |
| 2002 | Best Actress in a Lead Role | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2003 | Best Actress in a Lead Role | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2003 | Best TV Personality | Kyunki Saas Bhi Kabhi Bahu Thi | Tulsi Virani | Won |
| 2007 | Best Actress (Jury) | Virrudh | Vasudha Sushant Sharma | Won |
# Simonovic

Simonovic may refer to:
* Simonović (pronounced), a Serbian surname
* Šimonović (pronounced), a Croatian surname
# Francis Clarke (mathematician)

Frank "Francis" H. Clarke (born 30 July 1948, in Montreal) is a Canadian and French mathematician.

## Biography

Francis Clarke graduated in 1969 from McGill University with a B.Sc. degree in 1969 and in 1973 from the University of Washington with a Ph.D. with thesis advisor R. Tyrrell Rockafellar. In 1978 Clarke became a full professor at the University of British Columbia and gave an invited lecture at the International Congress of Mathematicians (ICM) in Helsinki. In 1984 he was appointed director of the Centre de Recherches Mathématiques (CRM) of the University of Montreal. During the nine years of his directorship, CRM became Canada's leading national research center for mathematics and its applications. The successes of Clarke's directorship included the creation of workshops and postdoctoral fellowships, thematic years, two series of publications, research awards, and an endowment fund. Francis Clarke is also the founding director of the Institut des Sciences Mathématiques (ISM) of Quebec.
In 1995 Francis Clarke was appointed full professor at Claude Bernard University Lyon 1, where he was a member of the Institut Camille-Jordan. In 2000 he was appointed to a chair in mathematical theory of control at the Institut universitaire de France. In 2004, he chaired the selection committee for the first joint conference of the six mathematical societies of Canada and France.

## Research

Francis Clarke is known for his contributions to nonsmooth analysis (a term that is due to him), and particularly for his theory of generalized gradients (gradients généralisés), as well as for his work in optimization, differential equations, control theory, calculus of variations, and modeling in several application domains. His book Optimization and Nonsmooth Analysis has over 11600 citations.

## Awards and honours

* W. T. and Idalia Reid Prize, Society for Industrial and Applied Mathematics [2015]
* Senior Member, Institut universitaire de France (chair in Control Theory), 2000.
* Prix Urgel-Archambault, Association francophone pour le savoir (ACFAS), 1990.
* Coxeter-James Prize, Canadian Mathematical Society, 1980
* Killam Fellowship (Bourse de recherché Killam) 1978–80, Council of Canada
* Fellow of the Royal Society of Canada, 1979.

## Books

* Optimization and Nonsmooth Analysis, Wiley, 1983 (Russian translation 1984). Reissue: SIAM Classics in Applied Mathematics, Vol. 5 (1990).
* Methods of Dynamic and Nonsmooth Optimization, SIAM, 1989.
* Nonsmooth Analysis and Control Theory (with Yu. Ledyaev, R. J. Stern and P. R. Wolenski), Graduate Texts in Mathematics 178, Springer-Verlag, 1998; 2008 pbk edition
* Functional Analysis, Calculus of Variations and Optimal Control, Graduate Texts in Mathematics 264, Springer, 2013.
# Heterotrichoncus

Heterotrichoncus is a monotypic genus of dwarf spiders containing the single species, Heterotrichoncus pusillus. It was first described by J. Wunderlich in 1970, and has only been found in Albania, Austria, Czech Republic, France, Russia, Slovakia, and Spain.
# Chiropteris

Chiropteris is an extinct genus of plants that existed from the Early Permian (Sakmarian stage) to the Late Jurassic (?Oxfordian stage, maybe latter).
It is unknown whether it belongs in the Matoniaceae or the Dipteridaceae.

## Description

The genus Chiropteris was named from fragmentary and whole-plant fossils. It was constituted of a short 25cm long petiole and a 16cm diameter circular leaf.

## Location

In Brazil, fossil of genus Chiropteris, was located on outcrop in the municipalities of São Jerônimo and Mariana Pimentel. They are in the geopark Paleorrota in Rio Bonito Formation and date from Sakmarian in Permian.
# Patay

Patay may refer to:

## People

* Franz Patay (born 1961), Austrian arts administrator
* Marius Patay {fr, de}, French inventor
* Pál Patay {de, hu, ia}, Hungarian archeologist
* Vilmos Patay (born 1953), Hungarian politician

## Places

* Patay, Argentina [es]
* Patay, Loiret, France
# List of conflicts in Angola

This is a list of conflicts in Angola arranged chronologically from the early modern period to the present day. This list includes nationwide and international wars, including: wars of independence, liberation wars, colonial wars, undeclared wars, proxy wars, territorial disputes, and world wars. Also listed might be any battle that occurred within the territory of what is today known as the, "Republic of Angola" but was itself only part of an operation of a campaign in a theater of a war. There may also be periods of violent civil unrest listed, such as: riots, shootouts, spree killings, massacres, terrorist attacks, and civil wars. The list might also contain episodes of: human sacrifice, mass suicide, massacres, and genocides.

## Early modern period
### Kingdom of Kongo

* c. 1506 – c. 1543 Afonso I of Kongo's Rise to Power
** 1506 Battle of Mbanza Kongo
* 1588–1654 Dutch–Portuguese War
** 29 October 1647 Battle of Kombi
* 1622 Kongo-Portuguese War
** 18 December 1622 Battle of Mbumbi
* 1665–1709 Kongo Civil War
** 30 October 1665 Battle of Mbwila
** June 1670 Battle of Mbidizi River
** 18 October 1670 Battle of Kitombo
** 15 February 1709 Battle of São Salvador

### Kingdom of Matamba

* 4 September 1681 Battle of Katole

## Contemporary history
### Portuguese Angola

* 4 February 1961 – 25 April 1974 Angolan War of Independence
* 11 November 1975 – 4 April 2002 Angolan Civil War
** September 1987 – March 1988 Battle of Cuito Cuanavale
* 8 November 1975 – Present Cabinda War
# Simonović

Simonović (Serbian Cyrillic: Симоновић, pronounced) is a Serbo-Croatian surname, a patronymic derived from the given name Simon. Notable people with the surname include:
* Ana Simonović (born 1969), Serbian politician and biologist
* Boško Simonović (1898–1965), Yugoslavian football coach, player, referee, and administrator
* Čolak-Anta Simonović (1777–1853), Serbian commander
* Dragoljub Simonović (born 1972), Bulgarian - Serbian former footballer
* Ifigenija Zagoričnik Simonović (born 1953), Slovene poet, essayist, writer, editor and potter
* Ljubodrag Simonović (born 1949), Serbian philosopher, author and former basketball player
* Marko Simonović (basketball, born 1982), Serbian assistant coach for Serbia men's national under-19 basketball team
* Marko Simonović (basketball, born 1986), Serbian basketball player (Hemofarm, Budućnost, Crvena zvezda, Zenit Saint Petersburg) and coach
* Marko Simonović (basketball, born 1999), Montenegrin basketball player (Olimpija Ljubljana, Mega Basket, Chicago Bulls)
* Saša Simonović (born 1975), former Serbian footballer
* Stojan Simonović (1872–1937), Serbian Chetnik, nicknamed Koruba
# TOP Sassenheim

Korfbalvereniging Tot Ons Plezier (KV TOP), usually known as TOP Sassenheim, is a Dutch korfball club located in Sassenheim, Netherlands. The club was founded on 12 July 1928 and they play their home games in sports accommodation De Korf. The team plays in white/red vertically striped shirts and black shorts / skirts.

## History

During the nineties TOP made small steps to enter the elite korfball competition. When in 2005 a new elite indoor competition was founded, the Korfbal League it took them 3 years to take part of this. Once the club entered this competition in 2008, they quickly emerged to the top, winning titles in 2011, 2014, 2016, 2017 and 2018.
At the end of the 2021-22 Korfball League season the team relegated to Korfbal League 2.

## Honours

* Dutch national champion indoor, 2x (2011 en 2015)
* Dutch national champion outdoor, 5x (2011, 2014, 2016, 2017, 2018)
* Europacup champion indoor, 5x (2012, 2015, 2017, 2018, 2019)
* Supercup champion outdoor, 1x (2015)
# Francis Clay

Francis Clay (November 16, 1923 – January 21, 2008) was an American jazz and blues drummer, best known for his work behind Muddy Waters in the 1950s and 1960s, and as an original member of the James Cotton band. Clay's jazz-influenced style is cited as an influence by many of the British Invasion rock 'n' rollers of the 1960s such as Charlie Watts and Ronnie Wood of the Rolling Stones and Faces, respectively.
Born and raised in Rock Island, Illinois, he started playing jazz, professionally at the age of 15, played drums behind many of the biggest names of 20th century popular American music.
In his career, Clay claimed to have backed Gypsy Rose Lee, and played with Jay McShann and Charlie Parker early on and with Jimi Hendrix while in New York's Greenwich Village. He can be heard on recordings including John Lee Hooker's Live at Cafe Au Go Go and can be seen and heard on documents from the Waters band's 1960 Newport Jazz Festival appearance, and on albums issued by the Arhoolie label by Big Mama Thornton and Lightning Hopkins, among many others.
Clay made his home in San Francisco in the late 1960s and became a part of the music scene in the Bay Area throughout the rest of his life. His birthday parties at the Biscuits and Blues nightclub were an annual gathering of the tribe, and he was known also as "the ambassador" at the annual San Francisco Blues Festival, where he was the subject of a tribute in 2007, and mourned in 2008.
Clay claimed to have been deprived of recognition for his compositional contributions to the Waters oeuvre. Songs he claimed to have composed and/or arranged included "Walking in the Park," "She's Nineteen Years Old" and "Tiger in Your Hole."

## Discography

With John Lee Hooker
* Live at Cafe Au Go Go (BluesWay, 1967)
With Lightnin' Hopkins
* Lightnin'! (Poppy, 1969)
* In the Key of Lightnin' (Tomato, 1969 [2002])
* Lightning Hopkins in Berkeley (Arhoolie, 1969 [1972])
With Jimmy Rogers
* Jimmy Rogers (Chess, 1950–60)
With Otis Spann
* The Blues Is Where It's At (BluesWay, 1966)
With Muddy Waters
* Muddy Waters Sings "Big Bill" (Chess, 1960)
* At Newport 1960 (Chess, 1960)
* Folk Singer (Chess, 1964)
# Pancreatic endopeptidase E

Pancreatic endopeptidase E (EC 3.4.21.70, cholesterol-binding proteinase, proteinase E, cholesterol-binding serine proteinase, pancreatic protease E, pancreatic proteinase E, cholesterol-binding pancreatic proteinase, CBPP, pancreas E proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
    Preferential cleavage: Ala-. Does not hydrolyse elastin
This enzyme is peptidase of family S1 (trypsin family) from pancreatic juice.
# Dana Levin

Dana Levin (born 1965) is a poet and teaches Creative Writing at Maryville University in St. Louis, where she serves as Distinguished Writer in Residence. She also teaches in the Warren Wilson College MFA Program for Writers. She lives in Saint Louis, Missouri.

## Life

She earned degrees from Pitzer College and the Creative Writing Program at New York University.
Her first book, In the Surgical Theatre, was chosen by Louise Gluck for the 1999 American Poetry Review/Honickman First Book Prize (Copper Canyon Press. Her second book, Wedding Day, was released in 2005 and her third, Sky Burial, in 2011. In reviewing Sky Burial, The New Yorker called it "utterly her own, and utterly riveting." the Los Angeles Times says of Levin's work, "Dana Levin's poems are extravagant...her mind keeps making unexpected connections and the poems push beyond convention...they surprise us." Her most recent book is Now Do You Know Where You Are, which was released by Copper Canyon Press in 2022.

## Awards

* 1999 National Endowment for the Arts Grant
* 2000 John C. Zacharis First Book Award
* 2003 PEN/Joyce Osterweil Award for Poetry, In the Surgical Theatre
* 2004 Rona Jaffe Foundation Writers' Award
* 2004 Witter Bynner Fellowship from the Library of Congress
* 2005 Whiting Award for poetry
* 2007 Guggenheim Fellowship in Poetry

## Works

* In The Surgical Theatre. American Poetry Review/Copper Canyon Press. 1999. ISBN 978-0-9663395-2-9.
* Wedding Day. Copper Canyon Press. 2005. ISBN 978-1-55659-219-5.
* Sky Burial. Copper Canyon Press. 2011. ISBN 978-1-55659-219-5.
* Banana Palace. Copper Canyon Press. 2016. ISBN 978-1-55659-505-9.
* Now Do You Know Where You Are, Copper Canyon Press, 2022

### Anthologies

* Michael Dumanis; Cate Marvin, eds. (2006). Legitimate dangers: American poets of the new century. Sarabande Books. ISBN 978-1-932511-29-1.
* Joan Murray, ed. (2006). The Pushcart Book of Poetry. Pushcart Press. ISBN 978-1-888889-34-5.
* Gerald Costanzo; Jim Daniels, eds. (2000). American poetry: the next generation. Carnegie Mellon University Press. ISBN 978-0-88748-343-1.
# Heterotrissocladius

Heterotrissocladius is a genus of European non-biting midges in the subfamily Orthocladiinae of the bloodworm family (Chironomidae). Larvae of species in this genus have been found at the bottom of Crater Lake. Eggs are laid on the surface of the water, before sinking to the bottom. There, the larvae feed on the sediment, before swimming to the surface, pupating, and emerging as adults.