OpenLLM-France/wikimedia huggingface dataset:
# Eana Jeans

Eana Blyth Jeans (16 August 1890 – 9 May 1986) was a New Zealand artist best known for her watercolour paintings of native New Zealand bush.

## Early life and family

Born in Brisbane, Queensland, Australia, on 16 August 1890, Jeans was the daughter of artist Blandina Jeans (née Maxwell) and Thomas William Jeans. The family moved to New Zealand in 1894, settling in the Leith Valley area of Dunedin. Jeans was educated at Otago Girls' High School.

## Art education and career

Jeans began studying art as a student at Otago Girls', under Fanny Wimperis. She later studied at the Dunedin School of Art and the Barn Studio, Dunedin, alongside notable New Zealand artists Alfred Henry O'Keeffe and Mabel Hill. In 1934 Jeans travelled to England and studied at the Slade School of Art in London and exhibited her work at the Paris Salon, Royal Institution of Watercolourists, the Royal Society of British Artists Salon and the Chelsea Art Society in London.
Returning to New Zealand, Jeans began to specialize in painting the bush around Ross Creek and the Leith Valley where she lived. She wrote of her inspiration in the 1960s: "Having had the privilege of living in the Leith Valley where ferns, trees, brooks and streams abound, one could not do other than come under their spell. Fortunate is New Zealand to have this unique and beautiful vegetation as a reserve of strength and life from which to absorb physical and spiritual powers."

## Death

Jeans died in Dunedin on 9 May 1986, and her body was cremated at the Dunedin Crematorium.

## Honours and legacy

Jeans was an honorary life member of the Otago Art Society, and her works are held in both private and public collections in New Zealand, including the Hocken Collection, the Dunedin Public Libraries and the Dunedin Public Art Gallery in Dunedin. In 2002 an exhibition of her paintings was held as part of the Otago Festival of the Arts.
# D.T.A.L.

D.T.A.L. was a chaotic hardcore band formed in Landskrona, south Sweden, in 1983 by the multi-artist Nelle (previously in The Bristles). Their first 7"EP "Time To Die" was released in 1984 and was followed by the 7"EP "A Beautiful Day" in 1985. 1988 the band contributed on the compilation LP "Really Fast Vol. 4" from Really Fast Records, and 1990 the compilation EP "Hard, raw and fast" from "Chicken Brain Records". The band split-up shortly thereafter. Many different members where in and out over the years and the music evolved from hardcore punk to death metal. In 1994 three songs from the 7"EP "Time To Die" were reissued on the 3CD compilation "Varning For Punk" from "Egg Tapes & Records".

## Members

* Nelle – drums 83-84/ vocals 84–86. Earlier in The Bristles.
* Moe – guitar & vocals 83–90. Later in Odium, Warmonger, Mangler, The Negatives.
* Fredde – vocals 83–84
* Tuben – drums/vocals (on & off ´til) 89. Later in Hyste'riah G.B.C and The Bristles.
* Snutte – bass & guitar 83–85. Later in Hyste'riah (founder and a k a J.B.Krown) and Hyste'riah G.B.C.
* Lankan- drums 84–85. Earlier in The Bristles.
* PG – drums 86–90 Later in Warmonger.
* Ingemar – bass 86. Earlier and later in The Bristles.
* Pagen – bass 86–90 Later in Warmonger.
* Levin – guitar 87–89
* Gruva – keyboard 88–90
# Izvorul Gropii

Izvorul Gropii may refer to:
* Izvorul Gropii, a tributary of the Lotru in Vâlcea County
* Izvorul Gropii, a tributary of the Bâsculița in Buzău County
# DCOP

DCOP may refer to:
* Desktop communication protocol, an inter-process communication (IPC) daemon by KDE used in K Desktop Environment 3
* Distributed constraint optimization, a framework for constraint optimization problems in which each variable may be owned by a different agent
* Deputy Commissioner of Police, a position in some police departments
# J. Hamilton-Holder

Joseph Hamilton-Holder (born 1 February 1912, date of death unknown) was a Trinidadian politician who became Mayor of Port of Spain in 1968. Hamilton-Holder had joined the City Corporation in 1956 after defeating Michael Lee Leung in the Southern Ward on a PNM ticket. He then served as Dennis Mahabir's deputy when Mahabir was elected in 1957 to 1959. To his honour a street in Port of Spain located near the Hasely Crawford Stadium was named after him. O'Connor Street now merges into Hamilton-Holder Street.
He also served as principal and founded Progressive Educational Institute. He was also a winner of the Chaconia Gold Medal.
# Cychrus benesi

Cychrus benesi is a species of ground beetle in the subfamily of Carabinae that is endemic to Sichuan, province of China. It was described by Deuve in 1997.
# Charles W. Hoffman

Charles W. Hoffman (1829 - 1896) was a founder of the Georgetown University Law Center and its first dean. Hoffman also served as the second Law Librarian of Congress.

## Dean of Georgetown Law

Hoffman is widely viewed as one of the three primary founders of Georgetown's law school alongside Hubley Ashton and Charles James in 1870. A lawyer by trade, Hoffman served as the school's first secretary and treasurer in its early years of operation, and oversaw rapid growth of its initial classes. He also played a role in recruiting sitting Supreme Court Justice Samuel Miller to serve as the school's sole salaried professor in 1873, and he helped found the school's Moot Court in 1875.
In 1877, Georgetown University President Patrick Healy established the Office of the Dean and asked Hoffman to serve in the role. Hoffman accepted and served as the school's first dean until 1891, when he was replaced by long-serving faculty member Martin Morris.
Hoffman also served as a professor of various subjects at Georgetown College both before and after the Civil War.

## Law Librarian of Congress

Hoffman served for thirteen years as the Law Librarian of Congress, much of it while he was Dean of Georgetown Law. He became the second person appointed to the Law Librarian position when he was selected in 1873 by Ainsworth Spofford, the Librarian of Congress.
Hoffman's tenure was marked by the growth and professionalization of the Law Library, which was a small space still located inside the U.S. Capitol Building at the end of the nineteenth century. The role of Law Librarian was granted floor privileges by the U.S. House of Representatives in 1880 and by the U.S. Senate in 1884.
Hoffman served as Law Librarian until 1886, when he resigned from the role. The Washington Post reported that his resignation was due to “mental trouble” suffered after the loss of his mother.

## Personal life

Hoffman never married and lived for many years on Capitol Hill. According to his obituary, he collected antique furniture and was known to host parties attended by prominent legal figures including Supreme Court Justice Stephen Field. Hoffman later lived with his mother at 927 Massachusetts Avenue in Washington, D.C.
Hoffman died of pneumonia in 1896 in Frederick, Maryland, where he had relatives. He left behind an estate of approximately $80,000, worth $2.93 million in 2023 dollars.
# Susan Francis

Susan Francis-Wilkes (née Radford; 14 October 1877 – 22 April 1946) was an Australian midwife and women's rights activist.

## Early life

Francis was born at Kelvin Grove in Brisbane to labourer William Radford and Selina, née Stapleton. On 20 February 1897 she married Arthur Rawlins, who was known as Francis. Susan came to Sydney around 1911 with two of their three living children, assuming the name "Tarrant" between 1915 and 1917.

## Career

From the 1920s Francis worked as a midwife, although she never qualified with the Nurses' Registration Board and was the subject of two inquiries. She was also active in the Australian Labor Party, running for the state seat of Bondi in 1927. From 1928 to 1935 she was president then secretary of the Labor Women's Organising Committee; she was also a delegate to the Interstate Women's Conference in 1930 and president of the Blind Workers' Union in 1931. She ran for Waverley Municipal Council as a Lang Labor candidate in 1932, during which it emerged that she had been convicted in 1930 for witnessing false enrolment cards at the 1930 state election in Bondi.
Francis was involved in efforts to establish the Hostel for Homeless Women and Girls as secretary of a Labor committee. Well respected in the labour movement, her second marriage on 18 April 1936 to John Laurence Wilkes was preceded by a large function in her honour organised by a Labor committee; Jack Lang paid tribute to her in the annual party conference. Following this marriage she became known as Nurse Francis-Wilkes. She remained active in the local Labor Party until her death from myocardial infarction and diabetes on 22 April 1946 in Sydney. She was buried with Catholic rites in Botany cemetery.
# 2023 Gent–Wevelgem

The 2023 Gent–Wevelgem in Flanders Fields was a road cycling one-day race that took place on 26 March 2023 in the provinces of West Flanders and Hainaut in west Belgium. It was the 85th edition of Gent–Wevelgem and the 12th event of the 2023 UCI World Tour.

## Teams

All 18 UCI WorldTeams and seven UCI ProTeams made up the 25 teams that participated in the race.
UCI WorldTeams
* AG2R Citroën Team
* Alpecin–Deceuninck
* Arkéa–Samsic
* Astana Qazaqstan Team
* Bora–Hansgrohe
* Cofidis
* EF Education–EasyPost
* Groupama–FDJ
* Ineos Grenadiers
* Intermarché–Circus–Wanty
* Movistar Team
* Soudal–Quick-Step
* Team Bahrain Victorious
* Team DSM
* Team Jayco–AlUla
* Team Jumbo–Visma
* Trek–Segafredo
* UAE Team Emirates
UCI ProTeams
* Bingoal WB
* Human Powered Health
* Israel–Premier Tech
* Lotto–Dstny
* Team Flanders–Baloise
* Team TotalEnergies
* Uno-X Pro Cycling Team

## Result

Result (1–10) :
| Rank | Rider | Team | Time |
| 1 | Christophe Laporte (FRA) | Team Jumbo–Visma | 5h 49' 39" |
| 2 | Wout van Aert (BEL) | Team Jumbo–Visma | + 0" |
| 3 | Sep Vanmarcke (BEL) | Israel–Premier Tech | + 1' 56" |
| 4 | Frederik Frison (BEL) | Lotto–Dstny | + 1' 56" |
| 5 | Mads Pedersen (DEN) | Trek–Segafredo | + 1' 56" |
| 6 | Mikkel Bjerg (DEN) | UAE Team Emirates | + 1' 56" |
| 7 | Alexis Renard (FRA) | Cofidis | + 2' 04" |
| 8 | Olav Kooij (NED) | Team Jumbo–Visma | + 2' 04" |
| 9 | Danny van Poppel (NED) | Bora–Hansgrohe | + 2' 04" |
| 10 | Daniel McLay (GBR) | Arkéa–Samsic | + 2' 04" |
# Sveistrup

Sveistrup is a Danish surname. Notable people with the surname include:
* Hans Sveistrup (1815–1893), Danish priest
* Poul Sveistrup (1848–1911), Danish social statistician
* Søren Sveistrup (born 1968), Danish screenwriter
* Jody Sveistrup (born 1969), Canadian curler
* Jakob Sveistrup (born 1972), Danish singer
# Swimming at the 2008 Summer Paralympics – Women's 100 metre breaststroke SB6

The women's 100m breaststroke SB6 event at the 2008 Summer Paralympics took place at the Beijing National Aquatics Center on 12 September. There were two heats; the swimmers with the eight fastest times advanced to the final.

## Results
### Heats

Competed from 10:41.

#### Heat 1

| Rank | Name | Nationality | Time | Notes |
| 1 | Sarah Bowen | Australia | 1:44.44 | Q |
| 2 | Deborah Gruen | United States | 1:46.76 | Q |
| 3 | Maria Goetze | Germany | 1:54.28 | Q |
| 4 | Steph McDougall | Canada | 1:56.10 | Q |
| 5 | Natasa Sobocan | Croatia | 2:04.88 | |
| 6 | Marianne Maeland | Norway | 2:10.55 | |

#### Heat 2

| Rank | Name | Nationality | Time | Notes |
| 1 | Elizabeth Johnson | Great Britain | 1:42.84 | Q |
| 2 | Charlotte Henshaw | Great Britain | 1:45.91 | Q |
| 3 | Miranda Uhl | United States | 1:50.80 | Q |
| 4 | Katrina Porter | Australia | 1:55.26 | Q |
| 5 | Lalita Loureiro | Sweden | 1:59.00 | |
| 6 | Casey Johnson | United States | 2:07.89 | |

### Final

Competed at 19:16.
| Rank | Name | Nationality | Time |
| | Elizabeth Johnson | Great Britain | 1:41.87 |
| | Sarah Bowen | Australia | 1:42.39 |
| | Deborah Gruen | United States | 1:44.00 |
| 4 | Charlotte Henshaw | Great Britain | 1:45.28 |
| 5 | Maria Goetze | Germany | 1:47.82 |
| 6 | Miranda Uhl | United States | 1:48.44 |
| 7 | Katrina Porter | Australia | 1:55.08 |
| 8 | Steph McDougall | Canada | 1:57.78 |
Q = qualified for final.
# J.W. McMillan

J.W. McMillan may refer to:
* James W. McMillan (1825-1903), American soldier
* J.W. McMillan (brick manufacturer) (1850-1925), Scottish-American businessman
# DIGITAL Q1

The Digital Q1 was a FUJIFILM digital camera model announced in 2003.
Its expected street price was listed at around £100.

## Features

The Digital Q1 is a compact 2 megapixel digital camera described as a budget beginners camera. The camera has 3 resolutions, plus a function to record compressed, low-resolution video (AVI format). It can be used as a webcam via the USB port. The DIGITAL Q1 is a low-cost, beginners model – only date and time need to be set. A 16 Mbyte xD card is included. The camera includes a battery-backed clock, allowing time and date to be included in the Exif record, which also includes shutter times. There are menu options to adjust brightness (and other) parameters, with little effect – the firmware aligns to a medium result.
* 1/2" CMOS sensor
* 4x digital zoom
* ISO 100, 200
* Built in flash
* Red-eye reduction
* Focal length = 46mm on a 35mm camera
* 1.5" colour LCD screen
* Focus: 120 cm to infinity
* Macro focus: approx. 60 to 120 cm
* File format: JPEG, AVI
* Memory: 8MB internal, optional xD-Picture Card
* USB output and cable
* Batteries: 2 x AA alkaline
* Neck strap

## Reception

Computer Active criticized the lack of optical zoom and plastic body, and rated the camera 3 out of 5 stars, saying: "As a fun snapper for holidays, nights out, or maybe as a first camera for the kids, it has plenty going for it. Serious photo fans should keep shopping."
# Miyama (surname)

Miyama (written: 美山 lit. "beauty mountain", 深山 lit. "mountain recess" or 宮間) is a Japanese surname. Notable people with the surname include:
* Aya Miyama (宮間 あや, born 1985), Japanese footballer
* Eijiro Miyama (宮間 英次郎, born 1934), Japanese artist
* Karen Miyama (美山 加恋, born 1996), Japanese actress
* Sajiro Miyama (宮間 佐治郎, born 1917), Japanese boxer
* Shizuo Miyama (深山 静夫), Japanese footballer
* Takuya Miyama (深山 卓也, born 1954), Japanese jurist
# Swimming at the 2004 Summer Paralympics – Men's 50 metre freestyle S12

The Men's 50 metre freestyle S12 swimming event at the 2004 Summer Paralympics was competed on 26 September. It was won by Dmytro Aleksyeyev, representing Ukraine.

## 1st round

* Qualified for final round

### Heat 1

26 Sept. 2004, morning session
| Rank | Athlete | Time | Notes |
| 1 | Wu Bin (CHN) | 25.69 | PR |
| 2 | Sergei Punko (BLR) | 25.97 | |
| 3 | Dmytro Kuzmin (UKR) | 26.36 | |
| 4 | Ebert Kleynhans (RSA) | 26.68 | |
| 5 | Sergiy Demchuk (UKR) | 26.83 | |
| 6 | Ziv Better (ISR) | 26.89 | |

### Heat 2

26 Sept. 2004, morning session
| Rank | Athlete | Time | Notes |
| 1 | Raman Makarau (BLR) | 25.58 | PR |
| 2 | Dmytro Aleksyeyev (UKR) | 25.74 | |
| 3 | Darren Leach (GBR) | 26.28 | |
| 4 | Emmanuel Provost (FRA) | 26.80 | |
| 5 | Kosei Egawa (JPN) | 26.83 | |
| 6 | Yury Rudzenok (BLR) | 27.49 | |

## Final round

26 Sept. 2004, evening session
| Rank | Athlete | Time | Notes |
| | Dmytro Aleksyeyev (UKR) | 24.80 | WR |
| | Raman Makarau (BLR) | 25.27 | |
| | Wu Bin (CHN) | 25.69 | |
| 4 | Sergei Punko (BLR) | 25.88 | |
| 5 | Dmytro Kuzmin (UKR) | 26.00 | |
| 6 | Darren Leach (GBR) | 26.08 | |
| 7 | Ebert Kleynhans (RSA) | 26.60 | |
| 8 | Emmanuel Provost (FRA) | 26.71 | |
# Swimming at the 2004 Summer Paralympics – Men's 50 metre freestyle S4

The Men's 50 metre freestyle S4 swimming event at the 2004 Summer Paralympics was competed on 27 September. It was won by Clodoaldo Silva, representing Brazil.

## 1st round

* Qualified for final round

### Heat 1

27 Sept. 2004, morning session
| Rank | Athlete | Time | Notes |
| 1 | Yuji Hanada (JPN) | 38.43 | PR |
| 2 | David Smétanine (FRA) | 41.75 | |
| 3 | Luca Mazzone (ITA) | 43.17 | |
| 4 | Fotios Zafeiris (GRE) | 44.77 | |
| 5 | Juan Ignacio Reyes (MEX) | 45.82 | |
| 6 | Arkaitz Garcia (ESP) | 52.61 | |

### Heat 2

27 Sept. 2004, morning session
| Rank | Athlete | Time | Notes |
| 1 | Clodoaldo Silva (BRA) | 36.40 | PR |
| 2 | Ricardo Oribe (ESP) | 40.31 | |
| 3 | Jan Povysil (CZE) | 41.61 | |
| 4 | Joe McCarthy (USA) | 44.80 | |
| 5 | Jose Arnulfo Castorena (MEX) | 47.72 | |
| | Kestutis Skucas (LTU) | DNS | |

## Final round

27 Sept. 2004, evening session
| Rank | Athlete | Time | Notes |
| | Clodoaldo Silva (BRA) | 35.41 | WR |
| | Yuji Hanada (JPN) | 37.54 | |
| | David Smétanine (FRA) | 39.51 | |
| 4 | Ricardo Oribe (ESP) | 39.67 | |
| 5 | Luca Mazzone (ITA) | 39.78 | |
| 6 | Jan Povysil (CZE) | 42.33 | |
| 7 | Joe McCarthy (USA) | 44.39 | |
| 8 | Fotios Zafeiris (GRE) | 44.87 | |
# Swimming at the 2004 Summer Paralympics – Men's 50 metre butterfly S7

The Men's 50 metre butterfly S7 swimming event at the 2004 Summer Paralympics was competed on 25 September. It was won by Tian Rong, representing China.

## 1st round

* Qualified for final round

### Heat 1

25 Sept. 2004, morning session
| Rank | Athlete | Time | Notes |
| 1 | Tian Rong (CHN) | 31.91 | WR |
| 2 | Pei Mang (CHN) | 33.46 | |
| 3 | David Roberts (GBR) | 35.32 | |
| 4 | Alex Harris (AUS) | 37.68 | |
| 5 | Daniel Kamber (USA) | 39.16 | |
| 6 | Tomas Scharf (CZE) | 39.68 | |
| 7 | Tadhg Slattery (RSA) | 40.53 | |

### Heat 2

25 Sept. 2004, morning session
| Rank | Athlete | Time |
| 1 | Yuriy Andryushin (UKR) | 32.91 |
| 2 | Daniel Kuenzi (SUI) | 35.34 |
| 3 | Matthew Walker (GBR) | 35.68 |
| 4 | Alex Hadley (AUS) | 36.60 |
| 5 | Daisuke Ejima (JPN) | 36.61 |
| 6 | Jose Arnulfo Medeiros (BRA) | 36.92 |
| 7 | Jose Arnulfo Ramos (ESP) | 37.57 |
| 8 | Dalibor Mach (CZE) | 37.91 |

## Final round

25 Sept. 2004, evening session
| Rank | Athlete | Time | Notes |
| | Tian Rong (CHN) | 31.32 | WR |
| | Pei Mang (CHN) | 32.91 | |
| | Yuriy Andryushin (UKR) | 33.12 | |
| 4 | David Roberts (GBR) | 33.94 | |
| 5 | Daniel Kuenzi (SUI) | 34.92 | |
| 6 | Matthew Walker (GBR) | 35.52 | |
| 7 | Daisuke Ejima (JPN) | 35.91 | |
| 8 | Alex Hadley (AUS) | 36.20 | |
# Swimming at the 2012 Summer Paralympics – Women's 400 metre freestyle S11

The women's 400 metre freestyle S11 event at the 2012 Paralympic Games took place on 7 September, at the London Aquatics Centre.
Two heats were held, one with five swimmers, the other one with six competitors. The swimmers with the eight fastest times advanced to the final.

## Heats
### Heat 1

| Rank | Lane | Name | Nationality | Time | Notes |
| 1 | 4 | Cecilia Camellini | Italy | 5:25.70 | Q, PR |
| 2 | 5 | Mary Fisher | New Zealand | 5:32.31 | Q, OC |
| 3 | 3 | Olga Iakibiuk | Ukraine | 5:43.89 | Q |
| 4 | 2 | Rina Akiyama | Japan | 6:21.58 | |
| 5 | 6 | Áine Kelly-Costello | New Zealand | 6:27.02 | |

### Heat 2

| Rank | Lane | Name | Nationality | Time | Notes |
| 1 | 4 | Daniela Schulte | Germany | 5:11.32 | Q, PR |
| 2 | 5 | Amber Thomas | Canada | 5:14.42 | Q, AM |
| 3 | 3 | Naomi Ikinaga | Japan | 6:02.91 | Q |
| 4 | 6 | Chantal Cavin | Switzerland | 6:05.55 | Q |
| 5 | 2 | Nadia Báez | Argentina | 6:19.35 | Q |
| 6 | 7 | Irina Lavrova | Russia | 7:01.18 | |

## Final

| Rank | Lane | Name | Nationality | Time | Notes |
| | 4 | Daniela Schulte | Germany | 5:14.36 | |
| | 5 | Amber Thomas | Canada | 5:15.48 | |
| | 3 | Cecilia Camellini | Italy | 5:20.27 | |
| 4 | 6 | Mary Fisher | New Zealand | 5:22.09 | OC |
| 5 | 2 | Olga Iakibiuk | Ukraine | 5:48.02 | |
| 6 | 7 | Naomi Ikinaga | Japan | 5:53.20 | AS |
| 7 | 1 | Chantal Cavin | Switzerland | 6:11.29 | |
| 8 | 8 | Nadia Báez | Argentina | 6:15.98 | |
# DKK1

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.

## Function

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.

## Interactions

DKK1 has been shown to interact with LRP6 and is a high affinity ligand of Kremen proteins.

## Clinical significance

Elevated levels of DKK1 in bone marrow, plasma and peripheral blood are associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Due to the role of DKK1 in inflammation induced bone loss DKK1 is under investigation as target for therapeutic strategies in medicine and dentistry.

## Animal studies

Scientists have created a DKK1 knockout model in mice that revealed the effects of this gene. All mice that were homozygous for the DKK1 knockout were dead at birth due to defects in the cranium and structures formed by the neural crest, such as failed development of eyes, olfactory placodes, frontonasal mass and mandibular processes, as well as incomplete development of the forebrain and midbrain and fusion of the digits of the forelimb. This evidence supports the idea that inhibition of the Wnt signaling pathway by DKK1 is crucial to proper cranial development.

## In vitro studies

DKK1 is one of the most upregulated genes in androgen-potentiated balding, with DKK-1 messenger RNA upregulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing antibody against DKK-1 reversed DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate in vitro, with the latter a metabolite of ascorbate.

## DKK1 and Alzheimer's

Alzheimer's disease occurs due to the overproduction of amyloid beta that will cluster together to form amyloid plaques between neurons in the brain and disrupt cell function. In addition, there is an accumulation of neurofibrillary tangles of hyperphosphorylated tau inside the neuron. The Wnt signaling pathway is crucial for brain development processes, which include neuron proliferation and differentiation as well as neuroblast migration and axon guidance. Downregulation of this signaling has been shown in those with Alzheimer's as a result of high levels of DKK1. Because of the hyperphosphorylation induced by DKK1, tau cannot interact with neuronal microtubules consequently compromising axonal transport resulting in synaptic loss and neuronal apoptosis. Because of its antagonistic effects on the Wnt signaling pathway, it is believed that DKK1 is a common marker for neuronal death in neurodegenerative diseases like Alzheimer's.