# 2022 Mexico City Open – Singles

This was the first edition of the tournament.
Marc-Andrea Hüsler won the title after defeating Tomás Martín Etcheverry 6–4, 6–2 in the final.

## Seeds

* Facundo Bagnis (first round)
* Tomás Martín Etcheverry (final)
* Stefan Kozlov (first round, retired)
* Andrej Martin (first round)
* Juan Ignacio Londero (second round)
* Ernesto Escobedo (first round)
* Nicolás Jarry (semifinals)
* Jay Clarke (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Marc-Andrea Hüsler | 7$^7$ | 6 | | | | | |
| | Felipe Meligeni Alves | 6$^5$ | 2 | | | | | |
| | Felipe Meligeni Alves | 6$^5$ | 2 | | | Marc-Andrea Hüsler | 6 | 6 |
| | | | | | 2 | Tomás Martín Etcheverry | 4 | 2 |
| 7/WC | Nicolás Jarry | 6 | 5 | 6$^4$ | 2 | Tomás Martín Etcheverry | 4 | 2 |
| 2 | Tomás Martín Etcheverry | 3 | 7 | 7$^7$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 1 | F Bagnis | 3 | 2 | | | | | | | | | | | | |
| | JP Ficovich | 6 | 6 | | | JP Ficovich | 4 | 1 | | | | | | | |
| | M-A Hüsler | 3 | 6 | 6 | | M-A Hüsler | 6 | 6 | | | | | | | |
| Q | Gilbert Klier Júnior | 6 | 3 | 4 | | | | | | M-A Hüsler | 6 | 6 | | | |
| | M Janvier | 6 | 7$^7$ | | | | | | | M Janvier | 3 | 3 | | | |
| WC | LC Álvarez | 3 | 6$^2$ | | | M Janvier | 3 | 6 | 7$^7$ | | | | | | |
| | G Oliveira | 5 | 7$^8$ | 3 | 5 | JI Londero | 6 | 3 | 6$^5$ | | | | | | |
| 5 | JI Londero | 7 | 6$^6$ | 6 | | | | | | | | | M-A Hüsler | 7$^7$ | 6 |
| 4 | A Martin | 2 | 1 | | | | | | | | | | F Meligeni Alves | 6$^5$ | 2 |
| | J de Jong | 6 | 6 | | | J de Jong | 0 | 6 | 3 | | | | | | |
| | R Olivo | 6 | 4 | 7$^7$ | | R Olivo | 6 | 2 | 6 | | | | | | |
| Q | N Chappell | 4 | 6 | 6$^2$ | | | | | | R Olivo | 6$^5$ | 3 | | | |
| Q | K Smith | 6 | 3 | 4 | | | | | | F Meligeni Alves | 7$^7$ | 6 | | | |
| Alt | P Krstin | 4 | 6 | 6 | Alt | P Krstin | 1 | 4 | | | | | | | |
| | F Meligeni Alves | 1 | 7$^7$ | 6 | | F Meligeni Alves | 6 | 6 | | | | | | | |
| 6 | E Escobedo | 6 | 6$^5$ | 2 | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7/WC | N Jarry | 4 | 7$^7$ | 6 | | | | | | | | | | | | | |
| Alt | V Durasovic | 6 | 6$^5$ | 2 | 7/WC | N Jarry | 7$^7$ | 6 | | | | | | | | | |
| | M Pucinelli de Almeida | 5 | 7$^7$ | 7$^8$ | | M Pucinelli de Almeida | 6$^5$ | 2 | | | | | | | | | |
| Alt | D Istomin | 7 | 6$^5$ | 6$^6$ | | | | | 7/WC | N Jarry | 7$^7$ | 7 | | | | | |
| | F Mena | 1 | 6 | 3 | | | | | | G Melzer | 6$^4$ | 5 | | | | | |
| Q | N Barrientos | 6 | 2 | 6 | Q | N Barrientos | 1 | 1 | | | | | | | | | |
| | G Melzer | 6 | 0 | | | G Melzer | 6 | 6 | | | | | | | | | |
| 3 | S Kozlov | 4 | 0$^r$ | | | | | | | | | | 7/WC | N Jarry | 6 | 5 | 6$^4$ |
| 8 | J Clarke | 6 | 6$^3$ | 6 | | | | | | | | | 2 | TM Etcheverry | 3 | 7 | 7$^7$ |
| Alt | B Tomic | 4 | 7$^7$ | 3 | 8 | J Clarke | 5 | 3 | | | | | | | | | |
| | F Gaio | 3 | 6 | 4 | Q | M Alves | 7 | 6 | | | | | | | | | |
| Q | M Alves | 6 | 3 | 6 | | | | | Q | M Alves | 1 | 1 | | | | | |
| Q | Elmar Ejupovic | 6 | 6 | | | | | | 2 | TM Etcheverry | 6 | 6 | | | | | |
| WC | A Hernández | 4 | 4 | | Q | E Ejupovic | 1 | 6$^2$ | | | | | | | | | |
| | E Donskoy | 3 | 2 | | 2 | TM Etcheverry | 6 | 7$^7$ | | | | | | | | | |
| 2 | TM Etcheverry | 6 | 6 | | | | | | | | | | | | | | |