# 2022 Internationaux de Tennis de Vendée – Singles

Jiří Veselý was the defending champion but chose not to defend his title.
Jelle Sels won the title after defeating Vasek Pospisil 6–4, 6–3 in the final.

## Seeds

* Jiří Lehečka (second round, retired)
* J. J. Wolf (quarterfinals)
* Hugo Gaston (semifinals)
* Richard Gasquet (first round)
* Quentin Halys (withdrew)
* Hugo Grenier (first round)
* Norbert Gombos (quarterfinals)
* Tomáš Macháč (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Jelle Sels | 6 | 6 | | | | | |
| Q | Jurgen Briand | 2 | 3 | | | | | |
| Q | Jurgen Briand | 2 | 3 | | | Jelle Sels | 6 | 6 |
| | | | | | WC | Vasek Pospisil | 4 | 3 |
| 3 | Hugo Gaston | 3 | 6 | 3 | WC | Vasek Pospisil | 4 | 3 |
| WC | Vasek Pospisil | 6 | 3 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | J Lehečka | 7$^{11}$ | 6 | | | | | | | | | | | | | | | |
| | T van Rijthoven | 6$^9$ | 4 | | 1 | J Lehečka | 6$^8$ | 2$^r$ | | | | | | | | | | |
| | J Sels | 5 | 6 | 6 | | J Sels | 7$^{10}$ | 4 | | | | | | | | | | |
| Q | David Poljak | 7 | 4 | 4 | | | | | | | J Sels | 6 | 6 | | | | | |
| WC | C Tabur | 3 | 4 | | | | | | | | O Virtanen | 3 | 4 | | | | | |
| | O Virtanen | 6 | 6 | | | O Virtanen | 6 | 6 | | | | | | | | | | |
| | G Simon | 6$^5$ | 6$^r$ | | LL | K de Schepper | 2 | 4 | | | | | | | | | | |
| LL | K de Schepper | 7$^7$ | 6 | | | | | | | | | | | | | J Sels | 6 | 6 |
| 4 | R Gasquet | 2 | 5 | | | | | | | | | | | | Q | J Briand | 2 | 3 |
| Q | Jurgen Briand | 6 | 7 | | Q | J Briand | 5 | 6 | 6 | | | | | | | | | |
| Q | M Bourgue | 6$^2$ | 6 | 6 | Q | M Bourgue | 7 | 4 | 3 | | | | | | | | | |
| | A Bellier | 7$^7$ | 4 | 3 | | | | | | Q | J Briand | 6 | 1 | 6 | | | | |
| Alt | A Cazaux | 7$^7$ | 6 | | | | | | | 8 | T Macháč | 3 | 6 | 3 | | | | |
| | J Forejtek | 6$^1$ | 4 | | Alt | A Cazaux | 2 | 4 | | | | | | | | | | |
| | A Vatutin | 5 | 6 | 3 | 8 | T Macháč | 6 | 6 | | | | | | | | | | |
| 8 | T Macháč | 7 | 2 | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | N Gombos | 2 | 6 | 6 | | | | | | | | | | | | | | |
| | A Escoffier | 6 | 1 | 2 | 7 | N Gombos | 6 | 7 | | | | | | | | | | |
| WC | A Fils | 5 | 5 | | Alt | V Sachko | 4 | 5 | | | | | | | | | | |
| Alt | V Sachko | 7 | 7 | | | | | | 7 | N Gombos | 4 | 4 | | | | | | |
| | E Furness | 2 | 0$^r$ | | | | | | 3 | H Gaston | 6 | 6 | | | | | | |
| Q | V Royer | 6 | 1 | | Q | V Royer | 6$^5$ | 4 | | | | | | | | | | |
| | H Laaksonen | 6$^6$ | 6 | 6$^7$ | 3 | H Gaston | 7$^7$ | 6 | | | | | | | | | | |
| 3 | H Gaston | 7$^8$ | 4 | 7$^9$ | | | | | | | | | | 3 | H Gaston | 3 | 6 | 3 |
| 6 | H Grenier | 6$^3$ | 4 | | | | | | | | | | | WC | V Pospisil | 6 | 3 | 6 |
| WC | V Pospisil | 7$^7$ | 6 | | WC | V Pospisil | 6 | 6 | | | | | | | | | | |
| | F Maestrelli | 1 | 7$^8$ | 3 | Q | J Marie | 3 | 3 | | | | | | | | | | |
| Q | Jules Marie | 6 | 6$^6$ | 6 | | | | | WC | V Pospisil | 4 | 6 | 7$^7$ | | | | | |
| | J Sock | 6 | 6 | | | | | | 2 | JJ Wolf | 6 | 3 | 6$^3$ | | | | | |
| Q | Alexis Gautier | 3 | 3 | | | J Sock | 6$^1$ | 4 | | | | | | | | | | |
| | D Masur | 3 | 5 | | 2 | JJ Wolf | 7$^7$ | 6 | | | | | | | | | | |
| 2 | JJ Wolf | 6 | 7 | | | | | | | | | | | | | | | |