# List of 2021 box office number-one films in Spain

This is a list of films which placed number one at the weekend box office for the year 2021 in Spain.
| # | Date | Film | Gross | Notes | Ref |
| 1 | January 3, 2021 | The Croods: A New Age | €787,446 | It was The Croods: A New Age second weekend at the top spot. | |
| 2 | January 10, 2021 | The Croods: A New Age | €206,753 | | |
| 3 | January 17, 2021 | The Croods: A New Age | €145,538 | | |
| 4 | January 24, 2021 | The Croods: A New Age | €106,205 | | |
| 5 | January 31, 2021 | The Croods: A New Age | €73,130 | | |
| 6 | February 7, 2021 | The Croods: A New Age | €67,876 | | |
| 7 | February 14, 2021 | The Croods: A New Age | €59,935 | The eighth weekend of The Croods: A New Age had the lowest number-one weekend of 2021. | |
| 8 | February 21, 2021 | New Order | €71,699 | New Order had the lowest number-one weekend debut of 2021. | |
| 9 | February 28, 2021 | The Little Things | €124,757 | | |
| 10 | March 7, 2021 | Raya and the Last Dragon | €257,626 | | |
| 11 | March 14, 2021 | Raya and the Last Dragon | €200,300 | | |
| 12 | March 21, 2021 | Raya and the Last Dragon | €212,104 | | |
| 13 | March 28, 2021 | Godzilla vs. Kong | €1,470,940 | | |
| 14 | April 4, 2021 | Godzilla vs. Kong | €1,197,172 | | |
| 15 | April 11, 2021 | Godzilla vs. Kong | €621,713 | | |
| 16 | April 18, 2021 | Mortal Kombat | €478,292 | | |
| 17 | April 25, 2021 | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train | €550,970 | | |
| 18 | May 2, 2021 | The Lord of the Rings: The Fellowship of the Ring | €314,206 | 2001 film re-release | |
| 19 | May 9, 2021 | The Lord of the Rings: The Two Towers | €292,703 | 2002 film re-release | |
| 20 | May 16, 2021 | The Lord of the Rings: The Return of the King | €289,511 | 2003 film re-release | |
| 21 | May 23, 2021 | Spiral | €275,707 | | |
| 22 | May 30, 2021 | Cruella | €666,244 | | |
| 23 | June 6, 2021 | The Conjuring: The Devil Made Me Do It | €1,526,292 | | |
| 24 | June 13, 2021 | The Conjuring: The Devil Made Me Do It | €832,411 | | |
| 25 | June 20, 2021 | The Conjuring: The Devil Made Me Do It | €547,065 | | |
| 26 | June 27, 2021 | Operación Camarón | €540,294 | Operación Camarón was the first of only two Spanish films to reach number one in 2021. | |
| 27 | July 4, 2021 | F9 | €2,800,097 | | . |
| 28 | July 11, 2021 | Black Widow | €1,633,024 | | |
| 29 | July 18, 2021 | Black Widow | €731,478 | | |
| 30 | July 25, 2021 | Space Jam: A New Legacy | €1,035,958 | | |
| 31 | August 1, 2021 | Old | €1,064,112 | | |
| 32 | August 8, 2021 | The Suicide Squad | €1,121,101 | | |
| 33 | August 15, 2021 | The Suicide Squad | €559,042 | | |
| 34 | August 22, 2021 | Free Guy | €509,933 | | |
| 35 | August 29, 2021 | PAW Patrol: The Movie | €498,416 | | |
| 36 | September 5, 2021 | Shang-Chi and the Legend of the Ten Rings | €1,518,763 | | |
| 37 | September 12, 2021 | Shang-Chi and the Legend of the Ten Rings | €915,810 | | |
| 38 | September 19, 2021 | Dune | €2,047,117 | | |
| 39 | September 26, 2021 | Dune | €1,223,770 | | |
| 40 | October 3, 2021 | No Time to Die | €2,183,770 | | |
| 41 | October 10, 2021 | No Time to Die | €1,316,437 | | |
| 42 | October 17, 2021 | Venom: Let There Be Carnage | €3,263,000 | | |
| 43 | October 24, 2021 | Venom: Let There Be Carnage | €1,413,798 | | |
| 44 | October 31, 2021 | Venom: Let There Be Carnage | €937,491 | | |
| 45 | November 7, 2021 | Eternals | €2,586,082 | | |
| 46 | November 14, 2021 | Way Down | €1,234,600 | Way Down was the second of only two Spanish film to reach number one in 2021 | |
| 47 | November 21, 2021 | Way Down | €975,500 | | |
| 48 | November 28, 2021 | Encanto | €1,520,495 | | |
| 49 | December 5, 2021 | Ghostbusters: Afterlife | €1,114,000 | | |
| 50 | December 12, 2021 | Encanto | €653,220 | Encanto reclaimed the number-one spot in its third weekend of release. | |
| 51 | December 19, 2021 | Spider-Man: No Way Home | €7,290,760 | Spider-Man: No Way Home had the highest number-one weekend of 2021. | |
| 52 | December 26, 2021 | Spider-Man: No Way Home | €2,470,000 | | |

## Highest-grossing films

Highest-grossing films of 2021 :
| Rank | Title | Distributor | Domestic gross |
| 1 | Spider-Man: No Way Home | Sony | €28,434,415 |
| 2 | Sing 2 | Universal | €9,546,151 |
| 3 | F9 | Universal | €9,545,343 |
| 4 | Venom: Let There Be Carnage | Sony | €8,928,499 |
| 5 | The Kids Are Alright | Warner Bros. | €8,493,358 |
| 6 | Dune | Warner Bros. | €8,241,598 |
| 7 | No Time to Die | Universal | €7,994,968 |
| 8 | Eternals | Disney | €7,357,371 |
| 9 | Encanto | Disney | €7,189,995 |
| 10 | Godzilla vs. Kong | Warner Bros. | €6,347,373 |