# John Isner career statistics

This is a list of main career statistics of American former professional tennis player John Isner. All statistics are according to the ATP Tour and ITF website.

## Performance timelines

Key :
| W | F | SF | QF | #R | RR | Q# | P# | DNQ | A | Z# | PO | G | S | B | NMS | NTI | P | NH |

### Singles

| Tournament | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | SR | W–L | Win% |
| Grand Slam tournaments |||||||||||||||||||||
| Australian Open | A | 1R | 1R | 4R | 3R | 3R | A | 1R | 3R | 4R | 2R | 1R | 1R | 3R | A | 1R | 1R | 0 / 14 | 15–14 | 52% |
| French Open | A | 1R | A | 3R | 1R | 2R | 3R | 4R | 2R | 4R | 3R | 4R | A | 2R | 3R | 3R | 1R | 0 / 14 | 22–14 | 61% |
| Wimbledon | A | 1R | A | 2R | 2R | 1R | 2R | 3R | 3R | 3R | 2R | SF | 2R | NH$^*$ | 1R | 3R | 1R | 0 / 14 | 18–14 | 56% |
| US Open | 3R | 1R | 4R | 3R | QF | 3R | 3R | 3R | 4R | 3R | 3R | QF | 3R | 1R | 1R | 2R | 2R | 0 / 17 | 32–16 | 67% |
| Win–loss | 2–1 | 0–4 | 3–2 | 8–4 | 7–4 | 5–4 | 5–3 | 7–4 | 8–4 | 10–4 | 6–4 | 12–4 | 3–3 | 3–3 | 2–3 | 5–3 | 1–4 | 0 / 59 | 87–58 | 60% |
| Year-end championships |||||||||||||||||||||
| ATP Finals | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | Alt | DNQ | DNQ | RR | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | 0 / 1 | 0–3 | 0% |
| National representation ||||||||||||||||||||
| Summer Olympics | NH | A | not held | not held | not held | QF | not held | not held | not held | A | not held | not held | not held | not held | A | NH | NH | 0 / 1 | 3–1 | 75% |
| Davis Cup | A | A | A | 1R | QF | SF | QF | PO | 1R | QF | QF | SF | A | RR | RR | A | A | 0 / 9 | 15–13 | 54% |
| ATP Tour Masters 1000 |||||||||||||||||||||
| Indian Wells Masters | A | 2R | 4R | 4R | 3R | F | 2R | SF | 4R | 4R | 3R | 2R | 4R | NH$^*$ | 3R | 4R | 1R | 0 / 15 | 26–14 | 65% |
| Miami Open | A | 1R | 2R | 3R | 4R | 3R | 3R | 4R | SF | 2R | 3R | W | F | NH$^*$ | 4R | 2R | 1R | 1 / 15 | 26–14 | 65% |
| Monte-Carlo Masters | A | A | A | A | A | A | 1R | A | 3R | A | A | A | A | NH$^*$ | A | A | A | 0 / 2 | 2–2 | 50% |
| Madrid Open | A | A | A | 3R | 2R | 2R | 2R | 3R | QF | A | A | QF | A | NH$^*$ | QF | 2R | A | 0 / 9 | 15–9 | 63% |
| Italian Open | A | A | A | 2R | 1R | 2R | 1R | 1R | 3R | A | SF | 2R | A | A | A | 2R | A | 0 / 9 | 9–9 | 50% |
| Canadian Open | A | A | 2R | A | 2R | SF | 1R | 1R | QF | 2R | 1R | 3R | 2R | NH$^*$ | SF | A | A | 0 / 11 | 15–11 | 58% |
| Cincinnati Masters | 1R | 2R | 2R | 2R | 1R | A | F | 3R | 1R | 2R | SF | 1R | 2R | 3R | 3R | QF | 1R | 0 / 16 | 23–16 | 59% |
| Shanghai Masters | NH | NH | 1R | 2R | A | 3R | 2R | 3R | 3R | 1R | 3R | A | 3R | NH$^*$ | NH$^*$ | NH$^*$ | A | 0 / 9 | 11–9 | 55% |
| Paris Masters | A | A | 2R | 2R | SF | 2R | 3R | 2R | QF | F | SF | 3R | 2R | A | A | 2R | A | 0 / 12 | 18–12 | 60% |
| Win–loss | 0–1 | 2–3 | 7–6 | 8–7 | 9–7 | 11–7 | 9–9 | 12–8 | 20–9 | 9–6 | 15–7 | 10–6 | 11–6 | 2–1 | 12–4 | 8–6 | 0–3 | 1 / 98 | 145–96 | 60% |
| Career statistics |||||||||||||||||||||
| | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | Career | Career | Career |
| Tournaments | 5 | 19 | 18 | 21 | 21 | 21 | 24 | 23 | 24 | 20 | 23 | 22 | 18 | 7 | 12 | 16 | 14 | 308 | 308 | 308 |
| Titles | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 2 | 1 | 0 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 16 | 16 | 16 |
| Finals | 1 | 0 | 0 | 4 | 3 | 4 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 1 | 31 | 31 | 31 |
| Hard win–loss | 8–4 | 9–12 | 25–17 | 29–13 | 26–13 | 27–12 | 27–16 | 29–13 | 31–16 | 23–14 | 26–16 | 21–18 | 25–17 | 9–9 | 18–10 | 12–11 | 6–10 | 11 / 215 | 351–221 | 61% |
| Clay win–loss | 0–0 | 1–3 | 2–1 | 8–10 | 4–7 | 10–7 | 8–5 | 6–5 | 10–6 | 5–5 | 7–4 | 8–5 | 0–0 | 1–1 | 5–2 | 7–4 | 0–2 | 1 / 60 | 82–67 | 55% |
| Grass win–loss | 0–1 | 1–4 | 0–0 | 1–1 | 6–1 | 8–2 | 4–3 | 4–2 | 4–3 | 5–2 | 6–3 | 5–1 | 5–1 | 0–0 | 0–1 | 4–2 | 3–2 | 4 / 33 | 56–29 | 66% |
| Overall win–loss | 8–5 | 11–19 | 27–18 | 38–24 | 36–21 | 45–21 | 39–24 | 39–20 | 45–25 | 33–21 | 39–23 | 34–24 | 30–18 | 10–10 | 23–13 | 23–17 | 9–14 | 16 / 308 | 489–317 | 61% |
| Win % | 62% | 37% | 60% | 61% | 63% | 68% | 62% | 66% | 64% | 61% | 63% | 59% | 63% | 50% | 64% | 58% | 39% | 61% | 61% | 61% |
| Year-end ranking | 106 | 144 | 34 | 19 | 18 | 14 | 14 | 19 | 11 | 19 | 17 | 10 | 19 | 25 | 24 | 41 | 173 | $22,430,808 | $22,430,808 | $22,430,808 |

### Doubles

| Tournament | 2003 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | SR | W–L | Win % |
| Grand Slam tournaments ||||||||||||||||||||||
| Australian Open | A | A | 1R | QF | 3R | A | A | A | A | A | A | A | A | A | A | A | A | 1R | 0 / 4 | 5–4 | 63% |
| French Open | A | A | 3R | A | A | 1R | A | A | A | A | A | A | A | A | A | A | A | A | 0 / 2 | 2–2 | 50% |
| Wimbledon | A | A | A | A | A | A | A | A | A | A | A | A | A | A | NH$^*$ | A | A | 1R | 0 / 1 | 0–1 | 0% |
| US Open | 1R | 1R | 1R | 2R | A | A | A | A | A | A | A | A | A | A | A | A | A | 1R | 0 / 5 | 1–5 | 16% |
| Win–loss | 0–1 | 0–1 | 2–3 | 4–2 | 2–1 | 0–1 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–3 | 0 / 12 | 8–12 | 40% |
| National representation ||||||||||||||||||||||
| Summer Olympics | NH | NH | A | not held | not held | not held | 1R | not held | not held | not held | A | not held | not held | not held | not held | A | NH | NH | 0 / 1 | 0–1 | 0% |
| Davis Cup | A | A | A | A | 1R | QF | SF | QF | PO | 1R | QF | QF | SF | A | RR | RR | A | A | 0 / 9 | 2–0 | 100% |
| ATP Tour Masters 1000 ||||||||||||||||||||||
| Indian Wells Masters | A | A | A | A | SF | 2R | F | 2R | SF | 2R | 2R | 1R | W | 1R | NH$^*$ | 2R | W | SF | 2 / 13 | 27–10 | 73% |
| Miami Open | A | A | A | A | 2R | 2R | A | 1R | A | SF | QF | 2R | 2R | QF | NH$^*$ | 2R | W | A | 1 / 10 | 16–9 | 64% |
| Monte-Carlo Masters | A | A | A | A | A | A | A | A | A | A | A | A | A | A | NH$^*$ | A | A | A | 0 / 0 | 0–0 | – |
| Madrid Open | A | A | A | A | 2R | SF | 1R | 2R | 2R | A | A | A | 1R | A | NH$^*$ | A | SF | A | 0 / 7 | 9–6 | 60% |
| Italian Open | A | A | A | A | F | W | 1R | 1R | 1R | 1R | A | QF | 2R | A | A | A | F | A | 1 / 9 | 15–8 | 65% |
| Canadian Open | A | A | A | A | A | A | A | A | A | A | 2R | A | A | 1R | NH$^*$ | A | A | A | 0 / 2 | 1–2 | 33% |
| Cincinnati Masters | A | 2R | QF | 2R | 2R | 1R | A | A | A | A | A | 1R | A | A | 2R | A | 1R | A | 0 / 8 | 6–7 | 46% |
| Shanghai Masters | not held | not held | not held | 1R | 1R | A | A | A | A | 2R | W | 1R | A | 2R | NH$^*$ | NH$^*$ | NH$^*$ | A | 1 / 6 | 7–4 | 64% |
| Paris Masters | A | A | A | A | 2R | 1R | 1R | 2R | 1R | 1R | A | 1R | QF | A | A | A | A | A | 0 / 8 | 4–7 | 36% |
| Win–loss | 0–0 | 1–1 | 2–1 | 1–2 | 11–6 | 9–5 | 4–4 | 3–5 | 4–2 | 5–5 | 9–3 | 3–5 | 8–4 | 3–4 | 1–1 | 2–2 | 17–3 | 3–1 | 5 / 63 | 85–53 | 62% |
| Career statistics ||||||||||||||||||||||
| | 2003 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | Career | Career | Career |
| Tournaments | 1 | 4 | 11 | 10 | 14 | 13 | 9 | 8 | 6 | 8 | 7 | 11 | 5 | 6 | 2 | 3 | 6 | 4 | 128 | 128 | 128 |
| Titles | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 8 | 8 | 8 |
| Finals | 0 | 0 | 1 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 1 | 3 | 0 | 14 | 14 | 14 |
| Overall win–loss | 0–1 | 2–4 | 10–10 | 9–9 | 23–11 | 18–11 | 7–9 | 4–8 | 5–4 | 6–8 | 9–5 | 10–10 | 9–4 | 5–6 | 1–2 | 7–2 | 23–6 | 3–4 | 151–114 | 151–114 | 151–114 |
| Win % | 0% | 33% | 50% | 50% | 68% | 62% | 44% | 33% | 56% | 43% | 64% | 50% | 69% | 45% | 33% | 78% | 79% | 43% | 57% | 57% | 57% |
| Year-end ranking | 1383 | 226 | 106 | 97 | 31 | 36 | 94 | 193 | 170 | 122 | 54 | 100 | 59 | 182 | 184 | 206 | 20 | 192 | | | |
$^*$ not held due to COVID-19 pandemic.
* 1 2 2020 Summer Olympics was postponed to 2021 due to the COVID-19 pandemic.
* 1 2 Held as Hamburg Masters (outdoor clay) until 2008, Madrid Masters (outdoor clay) 2009 – present.
* 1 2 Held as Madrid Masters (indoor hard) from 2002 to 2008, and Shanghai Masters (outdoor hard) 2009 – present.
* 1 2 Including appearances in Grand Slam and ATP World Tour main draw matches, in Summer Olympics, and not included in Davis Cup, World Team Cup, Laver Cup and the ATP Cup.
* 1 2 Including matches in Grand Slam, in ATP World Tour, in Summer Olympics, in Davis Cup, World team Cup, Laver Cup and the ATP Cup.

## Significant finals
### Masters 1000 finals
#### Singles: 5 (1 title, 4 runner-ups)

| Result | Year | Tournament | Surface | Opponent | Score |
| Loss | 2012 | Indian Wells Masters | Hard | Roger Federer | 6–7$^{(7–9)}$, 3–6 |
| Loss | 2013 | Cincinnati Masters | Hard | Rafael Nadal | 6–7$^{(8–10)}$, 6–7$^{(3–7)}$ |
| Loss | 2016 | Paris Masters | Hard (i) | Andy Murray | 3–6, 7–6$^{(7–4)}$, 4–6 |
| Win | 2018 | Miami Open | Hard | Alexander Zverev | 6–7$^{(4–7)}$, 6–4, 6–4 |
| Loss | 2019 | Miami Open | Hard | Roger Federer | 1–6, 4–6 |

#### Doubles: 8 (5 titles, 3 runner-ups)

| Result | Year | Tournament | Surface | Partner | Opponents | Score |
| Loss | 2010 | Italian Open | Clay | Sam Querrey | Bob Bryan Mike Bryan | 3–6, 2–6 |
| Win | 2011 | Italian Open | Clay | Sam Querrey | Mardy Fish Andy Roddick | w/o |
| Loss | 2012 | Indian Wells Masters | Hard | Sam Querrey | Rafael Nadal Marc López | 2–6, 6–7$^{(3–7)}$ |
| Win | 2016 | Shanghai Masters | Hard | Jack Sock | Henri Kontinen John Peers | 6–4, 6–4 |
| Win | 2018 | Indian Wells Masters | Hard | Jack Sock | Bob Bryan Mike Bryan | 7–6$^{(7–4)}$, 7–6$^{(7–2)}$ |
| Win | 2022 | Indian Wells Masters | Hard | Jack Sock | Santiago González Édouard Roger-Vasselin | 7–6$^{(7–4)}$, 6–3 |
| Win | 2022 | Miami Open | Hard | Hubert Hurkacz | Wesley Koolhof Neal Skupski | 7–6$^{(7–5)}$, 6–4 |
| Loss | 2022 | Italian Open | Clay | Diego Schwartzman | Nikola Mektić Mate Pavić | 2–6, 7–6$^{(8–6)}$, [10–12] |

## ATP career finals
### Singles: 31 (16 titles, 15 runner-ups)

* Legend
* Grand Slam tournaments (0–0)
* ATP World Tour Finals (0–0)
* ATP World Tour Masters 1000 (1–4)
* ATP World Tour 500 Series (0–3)
* ATP World Tour 250 Series (15–8)
* Finals by surface
* Hard (11–12)
* Clay (1–3)
* Grass (4–0)
* Finals by setting
* Outdoor (16–12)
* Indoor (0–3)
| Result | W–L | Date | Tournament | Tier | Surface | Opponent | Score |
| Loss | 0–1 | Aug 2007 | Washington Open, United States | International | Hard | Andy Roddick | 4–6, 6–7$^{(4–7)}$ |
| Win | 1–1 | Jan 2010 | Auckland Open, New Zealand | 250 Series | Hard | Arnaud Clément | 6–3, 5–7, 7–6$^{(7–2)}$ |
| Loss | 1–2 | Feb 2010 | US National Indoor, United States | 500 Series | Hard (i) | Sam Querrey | 7–6$^{(7–3)}$, 6–7$^{(5–7)}$, 3–6 |
| Loss | 1–3 | May 2010 | Serbia Open, Serbia | 250 Series | Clay | Sam Querrey | 6–3, 6–7$^{(4–7)}$, 4–6 |
| Loss | 1–4 | Jul 2010 | Atlanta Open, United States | 250 Series | Hard | Mardy Fish | 6–4, 4–6, 6–7$^{(4–7)}$ |
| Win | 2–4 | Jul 2011 | Hall of Fame Open, United States | 250 Series | Grass | Olivier Rochus | 6–3, 7–6$^{(8–6)}$ |
| Loss | 2–5 | Aug 2011 | Atlanta Open, United States | 250 Series | Hard | Mardy Fish | 6–3, 6–7$^{(6–8)}$, 2–6 |
| Win | 3–5 | Aug 2011 | Winston-Salem Open, United States | 250 Series | Hard | Julien Benneteau | 4–6, 6–3, 6–4 |
| Loss | 3–6 | Mar 2012 | Indian Wells Masters, United States | Masters 1000 | Hard | Roger Federer | 6–7$^{(7–9)}$, 3–6 |
| Loss | 3–7 | Apr 2012 | U.S. Men's Clay Court Championships, United States | 250 Series | Clay | Juan Mónaco | 2–6, 6–3, 3–6 |
| Win | 4–7 | Jul 2012 | Hall of Fame Open, United States (2) | 250 Series | Grass | Lleyton Hewitt | 7–6$^{(7–1)}$, 6–4 |
| Win | 5–7 | Aug 2012 | Winston-Salem Open, United States (2) | 250 Series | Hard | Tomáš Berdych | 3–6, 6–4, 7–6$^{(11–9)}$ |
| Win | 6–7 | Apr 2013 | U.S. Men's Clay Court Championships, United States | 250 Series | Clay | Nicolás Almagro | 6–3, 7–5 |
| Win | 7–7 | Jul 2013 | Atlanta Open, United States | 250 Series | Hard | Kevin Anderson | 6–7$^{(3–7)}$, 7–6$^{(7–2)}$, 7–6$^{(7–2)}$ |
| Loss | 7–8 | Aug 2013 | Washington Open, United States | 500 Series | Hard | Juan Martín del Potro | 6–3, 1–6, 2–6 |
| Loss | 7–9 | Aug 2013 | Cincinnati Masters, United States | Masters 1000 | Hard | Rafael Nadal | 6–7$^{(8–10)}$, 6–7$^{(3–7)}$ |
| Win | 8–9 | Jan 2014 | Auckland Open, New Zealand (2) | 250 Series | Hard | Lu Yen-hsun | 7–6$^{(7–4)}$, 7–6$^{(9–7)}$ |
| Win | 9–9 | Jul 2014 | Atlanta Open, United States (2) | 250 Series | Hard | Dudi Sela | 6–3, 6–4 |
| Win | 10–9 | Jul 2015 | Atlanta Open, United States (3) | 250 Series | Hard | Marcos Baghdatis | 6–3, 6–3 |
| Loss | 10–10 | Aug 2015 | Washington Open, United States | 500 Series | Hard | Kei Nishikori | 6–4, 4–6, 4–6 |
| Loss | 10–11 | Aug 2016 | Atlanta Open, United States | 250 Series | Hard | Nick Kyrgios | 6–7$^{(3–7)}$, 6–7$^{(4–7)}$ |
| Loss | 10–12 | Nov 2016 | Paris Masters, France | Masters 1000 | Hard (i) | Andy Murray | 3–6, 7–6$^{(7–4)}$, 4–6 |
| Win | 11–12 | Jul 2017 | Hall of Fame Open, United States (3) | 250 Series | Grass | Matthew Ebden | 6–3, 7–6$^{(7–4)}$ |
| Win | 12–12 | Jul 2017 | Atlanta Open, United States (4) | 250 Series | Hard | Ryan Harrison | 7–6$^{(8–6)}$, 7–6$^{(9–7)}$ |
| Win | 13–12 | Apr 2018 | Miami Open, United States | Masters 1000 | Hard | Alexander Zverev | 6–7$^{(4–7)}$, 6–4, 6–4 |
| Win | 14–12 | Jul 2018 | Atlanta Open, United States (5) | 250 Series | Hard | Ryan Harrison | 5–7, 6–3, 6–4 |
| Loss | 14–13 | Apr 2019 | Miami Open, United States | Masters 1000 | Hard | Roger Federer | 1–6, 4–6 |
| Win | 15–13 | Jul 2019 | Hall of Fame Open, United States (4) | 250 Series | Grass | Alexander Bublik | 7–6$^{(7–2)}$, 6–3 |
| Win | 16–13 | Jul 2021 | Atlanta Open, United States (6) | 250 Series | Hard | Brandon Nakashima | 7–6$^{(10–8)}$, 7–5 |
| Loss | 16–14 | Apr 2022 | U.S. Men's Clay Court Championships, United States | 250 Series | Clay | Reilly Opelka | 3–6, 6–7$^{(7–9)}$ |
| Loss | 16–15 | Feb 2023 | Dallas Open, United States | 250 Series | Hard (i) | Wu Yibing | 7–6$^{(7–4)}$, 6–7$^{(3–7)}$, 6–7$^{(12–14)}$ |

### Doubles: 14 (8 titles, 6 runner-ups)

* Legend
* Grand Slam tournaments (0–0)
* ATP Tour Finals (0–0)
* ATP Tour Masters 1000 (5–3)
* ATP Tour 500 Series (1–2)
* ATP Tour 250 Series (2–1)
* Finals by surface
* Hard (6–3)
* Clay (1–3)
* Grass (1–0)
* Finals by setting
* Outdoor (7–6)
* Indoor (1–0)
| Result | W–L | Date | Tournament | Tier | Surface | Partner | Opponents | Score |
| Win | 1–0 | Jul 2008 | Hall of Fame Open, United States | International | Grass | Mardy Fish | Rohan Bopanna Aisam-ul-Haq Qureshi | 6–4, 7–6$^{(7–1)}$ |
| Win | 2–0 | Feb 2010 | US National Indoor, United States | 500 Series | Hard (i) | Sam Querrey | Ross Hutchins Jordan Kerr | 6–4, 6–4 |
| Loss | 2–1 | May 2010 | Italian Open, Italy | Masters 1000 | Clay | Sam Querrey | Bob Bryan Mike Bryan | 2–6, 3–6 |
| Loss | 2–2 | Apr 2011 | U.S. Men's Clay Court Championships, United States | 250 Series | Clay | Sam Querrey | Bob Bryan Mike Bryan | 7–6$^{(7–4)}$, 2–6, [5–10] |
| Win | 3–2 | May 2011 | Italian Open, Italy | Masters 1000 | Clay | Sam Querrey | Mardy Fish Andy Roddick | Walkover |
| Loss | 3–3 | Mar 2012 | Indian Wells Masters, United States | Masters 1000 | Hard | Sam Querrey | Marc López Rafael Nadal | 2–6, 6–7$^{(3–7)}$ |
| Win | 4–3 | Oct 2016 | Shanghai Masters, China | Masters 1000 | Hard | Jack Sock | Henri Kontinen John Peers | 6–4, 6–4 |
| Loss | 4–4 | Mar 2017 | Mexican Open, Mexico | 500 Series | Hard | Feliciano López | Jamie Murray Bruno Soares | 3–6, 3–6 |
| Loss | 4–5 | Oct 2017 | China Open, China | 500 Series | Hard | Jack Sock | Henri Kontinen John Peers | 3–6, 6–3, [7–10] |
| Win | 5–5 | Mar 2018 | Indian Wells Masters, United States | Masters 1000 | Hard | Jack Sock | Bob Bryan Mike Bryan | 7–6$^{(7–4)}$, 7–6$^{(7–2)}$ |
| Win | 6–5 | Jul 2021 | Los Cabos Open, Mexico | 250 Series | Hard | Hans Hach Verdugo | Hunter Reese Sem Verbeek | 5–7, 6–2, [10–4] |
| Win | 7–5 | Mar 2022 | Indian Wells Masters, United States (2) | Masters 1000 | Hard | Jack Sock | Santiago González Édouard Roger-Vasselin | 7–6$^{(7–4)}$, 6–3 |
| Win | 8–5 | Apr 2022 | Miami Open, United States | Masters 1000 | Hard | Hubert Hurkacz | Wesley Koolhof Neal Skupski | 7–6$^{(7–5)}$, 6–4 |
| Loss | 8–6 | May 2022 | Italian Open, Italy | Masters 1000 | Clay | Diego Schwartzman | Nikola Mektić Mate Pavić | 2–6, 7–6$^{(8–6)}$, [10–12] |

## Other finals
### Team competition: 2 (1 title, 1 runner-up)

| Outcome | W–L | Date | Team competition | Surface | Partner/team | Opponents | Score |
| Win | 1–0 | Jan 2011 | Hopman Cup, Perth | Hard | Bethanie Mattek-Sands | Justine Henin Ruben Bemelmans | 2–1 |
| Loss | 1–1 | Jan 2015 | Hopman Cup, Perth | Hard | Serena Williams | Agnieszka Radwańska Jerzy Janowicz | 1–2 |

## Wins over top 10 players

* Isner had a 29–80 record against players who were, at the time the match was played, ranked in the top 10.
| Season | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | Total |
| Wins | 0 | 0 | 3 | 1 | 1 | 6 | 3 | 0 | 3 | 1 | 4 | 3 | 1 | 0 | 2 | 1 | 0 | 29 |
| # | Player | Rank | Event | Surface | Rd | Score | JIR |
| 2009 ||||||||
| 1. | Gaël Monfils | 9 | Indian Wells, United States | Hard | 2R | 6–7$^{(5–7)}$, 6–1, 6–4 | 147 |
| 2. | Jo-Wilfried Tsonga | 7 | Washington, United States | Hard | 2R | 4–6, 7–6$^{(7–2)}$, 7–6$^{(7–4)}$ | 80 |
| 3. | Andy Roddick | 5 | US Open, New York, United States | Hard | 3R | 7–6$^{(7–3)}$, 6–3, 3–6, 5–7, 7–6$^{(7–5)}$ | 55 |
| 2010 ||||||||
| 4. | Nikolay Davydenko | 6 | Beijing, China | Hard | QF | 7–6$^{(7–2)}$, 6–4 | 22 |
| 2011 ||||||||
| 5. | David Ferrer | 5 | Paris, France | Hard (i) | QF | 6–3, 3–6, 6–3 | 25 |
| 2012 ||||||||
| 6. | Roger Federer | 3 | Davis Cup, Fribourg, Switzerland | Clay (i) | RR | 4–6, 6–3, 7–6$^{(7–4)}$, 6–2 | 17 |
| 7. | Novak Djokovic | 1 | Indian Wells, United States | Hard | SF | 7–6$^{(9–7)}$, 3–6, 7–6$^{(7–5)}$ | 11 |
| 8. | Jo-Wilfried Tsonga | 6 | Davis Cup, Roquebrune-Cap-Martin, France | Clay | RR | 6–3, 7–6$^{(7–4)}$, 5–7, 6–3 | 11 |
| 9. | Janko Tipsarević | 8 | Olympics, London, United Kingdom | Grass | 3R | 7–5, 7–6$^{(16–14)}$ | 11 |
| 10. | Jo-Wilfried Tsonga | 6 | Winston-Salem, United States | Hard | SF | 6–4, 3–6, 7–6$^{(7–3)}$ | 10 |
| 11. | Tomáš Berdych | 7 | Winston-Salem, United States | Hard | F | 3–6, 6–4, 7–6$^{(11–9)}$ | 10 |
| 2013 ||||||||
| 12. | Milos Raonic | 10 | Cincinnati, United States | Hard | 3R | 7–6$^{(7–5)}$, 6–4 | 22 |
| 13. | Novak Djokovic | 1 | Cincinnati, United States | Hard | QF | 7–6$^{(7–5)}$, 3–6, 7–5 | 22 |
| 14. | Juan Martín del Potro | 7 | Cincinnati, United States | Hard | SF | 6–7$^{(5–7)}$, 7–6$^{(11–9)}$, 6–3 | 22 |
| 2015 ||||||||
| 15. | Milos Raonic | 6 | Miami, United States | Hard | 4R | 6–7$^{(3–7)}$, 7–6$^{(8–6)}$, 7–6$^{(7–5)}$ | 24 |
| 16. | Kei Nishikori | 5 | Miami, United States | Hard | QF | 6–4, 6–3 | 24 |
| 17. | Roger Federer | 2 | Paris, France | Hard (i) | 3R | 7–6$^{(7–3)}$, 3–6, 7–6$^{(7–5)}$ | 13 |
| 2016 ||||||||
| 18. | Marin Čilić | 10 | Paris, France | Hard (i) | SF | 6–4, 6–3 | 27 |
| 2017 ||||||||
| 19. | Stan Wawrinka | 3 | Rome, Italy | Clay | 3R | 7–6$^{(7–1)}$, 6–4 | 24 |
| 20. | Marin Čilić | 8 | Rome, Italy | Clay | QF | 7–6$^{(7–3)}$, 2–6, 7–6$^{(7–2)}$ | 24 |
| 21. | Rafael Nadal | 1 | Laver Cup, Prague, Czech Republic | Hard (i) | RR | 7–5, 7–6$^{(7–1)}$ | 17 |
| 22. | Grigor Dimitrov | 8 | Paris, France | Hard (i) | 3R | 7–6$^{(12–10)}$, 5–7, 7–6$^{(7–3)}$ | 14 |
| 2018 ||||||||
| 23. | Marin Čilić | 3 | Miami, United States | Hard | 4R | 7–6$^{(7–0)}$, 6–3 | 17 |
| 24. | Juan Martín del Potro | 6 | Miami, United States | Hard | SF | 6–1, 7–6$^{(7–2)}$ | 17 |
| 25. | Alexander Zverev | 5 | Miami, United States | Hard | F | 6–7$^{(4–7)}$, 6–4, 6–4 | 17 |
| 2019 ||||||||
| 26. | Alexander Zverev | 6 | Laver Cup, Geneva, Switzerland | Hard (i) | RR | 6–7$^{(2–7)}$, 6–4, [10–1] | 20 |
| 2021 ||||||||
| 27. | Andrey Rublev | 7 | Madrid, Spain | Clay | 3R | 7–6$^{(7–4)}$, 3–6, 7–6$^{(7–4)}$ | 39 |
| 28. | Andrey Rublev | 7 | Toronto, Canada | Hard | 3R | 7–5, 7–6$^{(7–5)}$ | 30 |
| 2022 ||||||||
| 29. | Hubert Hurkacz | 10 | Cincinnati, United States | Hard | 2R | 7–6$^{(7–5)}$, 6–7$^{(5–7)}$, 6–2 | 50 |