# HLA-B58

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.

## Serotype

B58 and B17 serotype recognition of some more common HLA B*58 alleles :
| B*58 | B58 | B17 | Sample |
| allele | % | % | size (N) |
| *5801 | 79 | 4 | 2096 |
| *5802 | 72 | 3 | 837 |

## Allele distribution

HLA B*5801 frequencies :
| | | freq |
| ref. | Population | (%) |
| | Cameroon Pygmy Baka | 15.0 |
| | India Khandesh Pawra | 15.0 |
| | Cameroon Sawa | 11.5 |
| | Taiwan Hakka | 10.9 |
| | Kenya Nandi | 10.0 |
| | India West Bhils | 9.0 |
| | China South Han | 8.9 |
| | China Inner Mongolia | 8.8 |
| | India North Delhi | 8.8 |
| | Thailand Northeast | 8.4 |
| | Guinea Bissau | 7.8 |
| | Thailand | 7.7 |
| | India Mumbai Marathas | 7.4 |
| | India Andhra Pradesh Golla | 7.2 |
| | Kenya Luo | 7.0 |
| | Senegal Niokholo Mandenka | 6.9 |
| | India New Delhi | 6.8 |
| | Oman | 6.8 |
| | Russia Tuva (2) | 6.7 |
| | South Korea (3) | 6.5 |
| | Italy Sardinia (3) | 6.4 |
| | Burkina Faso Fulani | 6.1 |
| | Taiwan Siraya | 5.9 |
| | India North Hindus | 5.8 |
| | Burkina Faso Mossi | 5.7 |
| | Cameroon Yaounde | 5.4 |
| | Cameroon Bamileke | 5.2 |
| | Singapore Riau Malay | 5.0 |
| | Saudi Arabia Guraiat and Hail | 4.6 |
| | France Corsica | 4.5 |
| | Sudanese | 4.5 |
| | Zimbabwe Harare Shona | 4.4 |
| | Burkina Faso Rimaibe | 4.3 |
| | Iran Baloch | 4.0 |
| | South African Natal Zulu | 4.0 |
| | Tunisia | 4.0 |
| | Uganda Kampala | 4.0 |
| | Cameroon Beti | 3.7 |
| | Tunisia Ghannouch | 3.7 |
| | Taiwan Pazeh | 3.6 |
| | Tunisia Tunis | 3.4 |
| | Italy North (1) | 3.3 |
| | Israel Ashkenazi and Non Ashkenazi Jews | 3.2 |
| | India West Coast Parsis | 3.0 |
| | China North Han | 2.9 |
| | Ivory Coast Akan Adiopodoume | 2.3 |
| | Mali Bandiagara | 2.2 |
| | Mexico Zaptotec Oaxaca | 2.2 |
| | South Africa Natal Tamil | 2.0 |
| | China Yunnan Nu | 1.9 |
| | Bulgaria | 1.8 |
| | China Tibet Autonomous Region Tibetans | 1.6 |
| | France South East | 1.6 |
| | Israel Arab Druse | 1.5 |
| | Czech Republic | 1.4 |
| | Georgia Tbilisi Georgians | 1.4 |
| | Jordan Amman | 1.4 |
| | Morocco Nador Metalsa (berber) | 1.4 |
| | Croatia | 1.3 |
| | Romanian | 1.3 |
| | Spain Eastern Andalusia | 1.2 |
| | Australian Aborigine Cape York Peninsula | 1.0 |
| | B*5802 | B*5802 |
| | Cameroon Bamileke | 14.3 |
| | Kenya Luo | 12.5 |
| | Cameroon Yaounde | 10.9 |
| | Cameroon Pygmy Baka | 10.0 |
| | Cameroon Beti | 9.8 |
| | Kenya Nandi | 8.5 |
| | South African Natal Zulu | 8.5 |
| | Cameroon Sawa | 7.7 |
| | Zimbabwe Harare Shona | 6.4 |
| | Cape Verde Northwestern Islands | 5.6 |
| | Uganda Kampala | 4.4 |
| | Central Africa Republic Mbenzele Pygmy | 4.0 |
| | Zambia Lusaka | 2.3 |
| | Iran Baloch | 1.0 |
| | Tunisia | 1.0 |

## Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.