# 2023 Challenger Santa Fe II – Singles

Mariano Navone was the defending champion and successfully defended his title after defeating Andrea Pellegrino 3–6, 6–2, 6–3 in the final.

## Seeds

* Federico Coria (quarterfinals, retired)
* Juan Manuel Cerúndolo (first round)
* Tomás Barrios Vera (quarterfinals)
* Vít Kopřiva (semifinals)
* Francisco Comesaña (second round)
* Jan Choinski (first round, retired)
* Genaro Alberto Olivieri (first round, retired)
* Felipe Meligeni Alves (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Andrea Pellegrino | 6 | 6 | | | | |
| 4 | Vít Kopřiva | 1 | 3 | | | | |
| 4 | Vít Kopřiva | 1 | 3 | Andrea Pellegrino | 6 | 2 | 3 |
| | | | | Mariano Navone | 3 | 6 | 6 |
| | Mariano Navone | 7 | 6 | Mariano Navone | 3 | 6 | 6 |
| | Thiago Monteiro | 5 | 4 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | F Coria | 6 | 7 | | | | | | | | | | | | | | |
| Q | N Mejía | 4 | 5 | | 1 | F Coria | 4 | 7$^7$ | 7$^7$ | | | | | | | | |
| | F Agamenone | 3 | 4 | | | J Kovalík | 6 | 6$^5$ | 6$^2$ | | | | | | | | |
| | J Kovalík | 6 | 6 | | | | | | | 1 | F Coria | 0 | 2$^r$ | | | | |
| Alt | M Trungelliti | 6 | 6 | | | | | | | | A Pellegrino | 6 | 3 | | | | |
| | A Collarini | 3 | 4 | | Alt | M Trungelliti | 1 | 6 | 4 | | | | | | | | |
| | A Pellegrino | 6 | 3 | | | A Pellegrino | 6 | 2 | 6 | | | | | | | | |
| 6 | J Choinski | 4 | 0$^r$ | | | | | | | | | | | | A Pellegrino | 6 | 6 |
| 4 | V Kopřiva | 6 | 0 | 6 | | | | | | | | | | 4 | V Kopřiva | 1 | 3 |
| Q | AD Vallejo | 0 | 6 | 3 | 4 | V Kopřiva | 6 | 6 | | | | | | | | | |
| | G Bueno | 6 | 3 | 0 | WC | RA Burruchaga | 3 | 0 | | | | | | | | | |
| WC | RA Burruchaga | 4 | 6 | 6 | | | | | | 4 | V Kopřiva | 6 | 6 | | | | |
| Q | B Bicknell | 2 | 2 | | | | | | | WC | F Delbonis | 4 | 3 | | | | |
| WC | F Delbonis | 6 | 6 | | WC | F Delbonis | 6 | 6 | | | | | | | | | |
| | L Neumayer | 5 | 1 | | 8 | F Meligeni Alves | 1 | 3 | | | | | | | | | |
| 8 | F Meligeni Alves | 7 | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 5 | F Comesaña | 6 | 6 | | | | | | | | | | | | | |
| | R Bonadio | 4 | 2 | | 5 | F Comesaña | 3 | 6 | 4 | | | | | | | |
| | M Navone | 6$^7$ | 6 | 6 | | M Navone | 6 | 3 | 6 | | | | | | | |
| Q | Alex Barrena | 7$^9$ | 2 | 2 | | | | | | | M Navone | 7$^7$ | 6 | | | |
| WC | JB Torres | 1 | 0$^r$ | | | | | | | 3 | T Barrios Vera | 6$^2$ | 4 | | | |
| | L Darderi | 6 | 4 | | | L Darderi | 4 | 6 | 6$^3$ | | | | | | | |
| | G Andreozzi | 6$^3$ | 2 | | 3 | T Barrios Vera | 6 | 4 | 7$^7$ | | | | | | | |
| 3 | T Barrios Vera | 7$^7$ | 6 | | | | | | | | | | | M Navone | 7 | 6 |
| 7 | GA Olivieri | 5 | 0$^r$ | | | | | | | | | | | T Monteiro | 5 | 4 |
| | F Bagnis | 7 | 2 | | | F Bagnis | 6 | 6 | | | | | | | | |
| LL | JP Ficovich | 3 | 2 | | | D Svrčina | 3 | 4 | | | | | | | | |
| | D Svrčina | 6 | 6 | | | | | | | | F Bagnis | 2 | 0 | | | |
| Q | C Taberner | 6 | 7 | | | | | | | | T Monteiro | 6 | 6 | | | |
| Q | P Boscardin Dias | 4 | 5 | | Q | C Taberner | 4 | 6 | 1 | | | | | | | |
| | T Monteiro | 6 | 2 | 7$^7$ | | T Monteiro | 6 | 4 | 6 | | | | | | | |
| 2 | JM Cerúndolo | 3 | 6 | 6$^4$ | | | | | | | | | | | | |