# List of fictional scientists and engineers

In addition to the archetypical mad scientist, there are fictional characters of scientists and engineers who go above and beyond the regular demands of their professions to use their skills and knowledge for the betterment of others, often at great personal risk. In this list of fictional scientists and engineers, an alphabetical overview is given of notable characters in this category.

## In literature

* Martin Arrowsmith from Arrowsmith
* Joseph Cavor from The First Men in the Moon – The inventor of the "Cavorite" anti-gravity material
* Captain [Hagbard Celine]] from Illuminatus trilogy – He fights the Illuminati from his submarine and with his computer, both designed by himself
* Norma Cenva from Legends of Dune – The inventor of the space folding engine
* Captain Jaylen Cresida from The Lost Fleet – The captain in the Alliance Navy under the command of Captain John "Black Jack" Geary, and an expert on hypernet gates.
* Dr. Claire Deller from I, Robot and other stories by Isaac Asimov – The chief robot genius of San Diego Robots and Mechanical Men
* Leonid Gorbovsky from Noon Universe – A genius scientist, progressor and spaceship captain who is known for his ability to land on even the most dangerous planets, to survive planet-wide catastrophes and easily making contact with any non-human civilization
* Leo Graf from Falling Free – A space engineer who leads a group of genetically engineered four-armed humans known as "quaddies" to freedom
* Gennady Komov from Noon Universe – A xenopsychologist whose main occupation is engaging contact with and studying alien (especially, non-human) civilizations.
* Chen Kui-lin from The Pig, the Snake and the Pigeon: My Idiotic Multiple Lives - A scientist in the hell mentioned by the one-eyed Chen Kui-lin
* Pardot Kynes from Prelude to Dune – A planetologist
* Liet-Kynes from Prelude to Dune and Dune – A planetologist
* William Harper "Johnny" Littlejohn from Doc Savage – An archaeologist and associate of Doc Savage
* Lt. Col Andrew Blodgett "Monk" Mayfair from Doc Savage – A chemist associate of Doc Savage
* Dr. Morel from The Invention of Morel – He invented a machine that records and reproduces reality
* Other Mother from Coraline
* Captain Nemo from Twenty Thousand Leagues Under the Seas and The Mysterious Island – An ambiguous-to-villainous figure, who later took on a heroic role
* Leonard of Quirm from Discworld – A super-intelligent clockpunk engineer
* Col John "Renny" Renwick from Doc Savage – A civil engineer and associate of Doc Savage
* Maj Thomas J. "Long Tom" Roberts from Doc Savage – An electrical engineer and associate of Doc Savage
* Dr. Clark Savage, Jr., a.k.a. Doc Savage (Doc Savage) – A surgeon, scientist, adventurer, inventor, explorer, and musician.
* Arne Saknussemm from Journey to the Center of the Earth – A 16th-century Icelandic naturalist, alchemist, and traveler whose messages guide a group of 19th-century adventurers
* Hari Seldon from Foundation Series – A mathematician who invents psychohistory
* Professor Shonku from Byomjatrir Diary, Professor Shonku o Robu, Professor Shonku o Khoka, Professor Shonku o Corvus, Ek Sringo Obhijaan, Swarnaparni and many more by the legendary Satyajit Ray – The world's most respected scientist, inventor and Physics professor in Scottish Church College. He had a bunch of incredible inventions and a series of adventures which he had written in his diary.
* Cyrus Smith from The Mysterious Island – A great literary example of a 19th-century engineer
* Dr. Phineas Waldolf Steel – A roboticist, transhumanist, and industrial/steampunk musician
* Franny K. Stein – A child scientist who frequently invents monsters to combat various danger
* Tom Swift and Tom Swift, Jr. – A father-and-son team of inventors
* Crawford Tillinghast from the short story "From Beyond" – The inventor of a machine which allows perception of normally imperceptible things
* Professor Abraham Van Helsing (Dracula) – The nemesis of Count Dracula. In later incarnations, the professor has not fared so well and in some adaptations, is himself a villain like in Hotel Transylvania 3: Summer Vacation.
* Mark Watney from The Martian – A botanist, mechanical engineer, astronaut
* Bertrand Zobrist from Inferno

## In live-action films
### Individual scientist/engineers in live-action films

* Eleanor Arroway from Contact – A scientist who searches for extraterrestrial intelligence.
* Dr. Robert Bruce Banner from The Incredible Hulk, The Avengers, Avengers: Age of Ultron, Thor: Ragnarok, Avengers: Infinity War, Avengers: Endgame) – A renowned scientist with 7 PhDs (focus in gamma radiation).
* Buckaroo Banzai from The Adventures of Buckaroo Banzai Across the 8th Dimension – Aparticle physicist, neurosurgeon, test pilot, martial artist and rock star.
* Professor Barnhardt from The Day the Earth Stood Still – An American scientist who organizes a scientific reception for Klaatu's message of peace
* Dr. Glenn Barton from The Man and the Challenge – A human-factors scientist
* Blankman – A science whiz-nerd who believes he is a superhero, and becomes one
* Dr. Emmett Brown, aka Doc Brown from Back to the Future, Back to the Future Part II, and Back to the Future Part III – An inventor of the Flux Capacitor which makes time travel possible
* Seth Brundle from The Fly – An eccentric but brilliant physicist who invented the telepods, machines capable of teleportation
* Sebastian Caine from Hollow Man - A scientist part of a team that worked on an invisibility serum and its antidote that tested it on other animals. He goes insane when the invisibility serum tested on him became irreversible.
* Jackson Curtis from 2012 – A struggling science-fiction writer.
* Dr. Miles Bennett Dyson from Terminator 2: Judgment Day – He learns of the destructive destiny of his future creation. Dyson later destroys his research.
* Dr. Stephen Falken from WarGames) – The creator of the "Joshua" computer program
* Dr. Charles Forbin from Colossus: The Forbin Project – The designer of Colossus
* Dr. Clayton Forrester from The War of the Worlds
* Charlie Frost from 2012 – A fringe science conspiracy theorist and radio talk-show host. Killed in the scene where the Yellowstone Caldera erupted.
* Kaywinnet Lee Frye from Serenity – A mechanical engineer
* Dr. Leslie Gaskell from Kronos) – He came up with a way to destroy the giant machine
* Richard Hannay from The Thirty-Nine Steps and Greenmantle – British mining engineer who is the hero in John Buchan's World War I-era adventure novels; The Thirty-Nine Steps has been adapted for film three times
* Adrian Helmsley from 2012 – A geologist, chief science advisor to U.S. President Thomas Wilson
* Dr. Newton Geiszler from Pacific Rim and Pacific Rim Uprising – K-Science Officer (biologist/research team)
* Dr. Hermann Gottlieb from Pacific Rim and Pacific Rim Uprising – K-Science Officer (mathematician/research team)
* Dr. Stanley Goodspeed from The Rock – AFBI chemical weapons specialist
* Corporal Hardin from Southern Comfort – A chemical engineer in regular life on weekend maneuvers with Louisiana Army National Guard squad in rural bayou country as they antagonize some local Cajun people and become hunted. His day job is only relevant to explain his rational sensible approach.
* Professor Eddie Jessup from Altered States – He was heroic at the end
* Indiana Jones from theIndiana Jones movies and TV shows – An adventurous archaeologist
* John Koestler from Knowing – An astrophysicist at Massachusetts Institute of Technology. Killed at the end of the movie when the massive solar flare destroys and ignites Earth.
* David Levinson from Independence Day – A cable-TV engineer who devises the trick that blocks the alien invasion
* der Leitende - LI from das Boot - The chief engineer of U-96 portrayed by Klaus Wennemann after real-life chief engineer Friedrich (Fritz) Grade
* Dr. Emilio Lizardo from The Adventures of Buckaroo Banzai Across the 8th Dimension – A physicist whose mind is under control of the Black Lectroid, Lord John Whorfin
* Ian Malcolm from Jurassic Park – A mathematician and chaotician surviving numerous encounters with dinosaurs and other hazards. His mathematical prowess does not help so much as allow him to predict his own fate, and that of the park's inhabitants
* Dr. Russell A. Marvin from Earth vs. the Flying Saucers – He invented the weapon that brought down the saucers
* Leonora Orantes from Contagion – A World Health Organization epidemiologist
* Q from James Bond – He makes all the gadgets 007 uses; Q is most often portrayed using the conventional literary trappings of a scientist (such as a white lab coat), even though his activities are closer to engineering
* Hank Rearden from Atlas Shrugged – A metallurgist and railroad magnate who is the inventor of "Rearden metal"
* David Reed from the Creature from the Black Lagoon – Contrasted to Mark Williams, a hypermasculine and ultimately destructive scientist
* Ellen Ripley from Alien/Aliens – An engineer aboard the star ship Nostromo
* Menlo Schwartzer from Surf II: The End of the Trilogy – A reputedly brilliant chemist
* Erik Selvig from Thor, The Avengers, Thor: The Dark World, Avengers: Age of Ultron - Astrophysics, worked with Jane Foster on her Wormhole research, associate of Thor and former partner of Bruce Banner. Latter worked for S.H.I.E.L.D. to study the Tessaract.
* Dr. Daisuke Serizawa from Gojira/Godzilla – A scientist who invents the Oxygen Destroyer, uses it to destroy Godzilla, then destroys his notes and sacrifices his own life so his creation can never be misused
* Dr. Jeffrey Stewart from The Magnetic Monster – He personally destroyed the dangerous substance
* Dr. Thomas Stockmann from An Enemy of the People
* Dr. Ryan Stone from Gravity – A biomedical engineer at a hospital in Lake Zurich; later becomes a mission specialist at NASA
* Satnam Surtani from 2012 – An Indian astrophysicist
* Professor Wayne Szalinski from Honey, I Shrunk the Kids - He invented a shrink ray.
* Mark Watney from The Martian – A botanist, mechanical engineer, and astronaut
* Dr. William Weir from Event Horizon – The designer of the titular spacecraft and its FTL propulsion system, the "gravity drive"
* Steve Zissou from The Life Aquatic with Steve Zissou – An eccentric oceanographer who sets out to exact revenge on the "jaguar shark".

## In live-action television
### Individual scientist/engineers in live-action television

* Reginald Barclay from Star Trek: The Next Generation and Star Trek: Voyager – A diagnostic technician transferred to the USS Enterprise-D who later played a key role in a later project which enabled regular contact with the missing Starfleet ship, USS Voyager
* Janos Bartok from Legend – A Hungarian scientist and inventor
* Chuck Bartowski from Chuck – A nerd who uses his skills to save the day many times
* Julian Bashir from Star Trek: Deep Space Nine – The chief medical officer on Deep Space Nine
* Beaker from The Muppet Show – The assistant scientist at Muppet Labs.
* Beakman from Beakman's World – A general scientist who, in a funny and entertaining manner, teaches that science is a fact of life
* Walter White from Breaking Bad – A former chemist who, after getting diagnosed with terminal lung cancer, starts manufacturing meth to provide for his family
* Carson Beckett from Stargate Atlantis – A medical doctor and geneticist who discovers the ATA gene and serves as the chief medical officer for the Atlantis expedition
* Sam Beckett from Quantum Leap – Nobel-prize winning quantum physicist (with multiple doctorates) caught in his own time-travel experiment; "leaping" into many lives along the span of his own lifetime, he must change the histories of those around him for the better before he can return home
* Brains from Thunderbirds – An engineer
* Lieutenant Colonel Samantha Carter, Ph.D. from Stargate SG-1 – A United States Air Force officer and astrophysicist whose scientific knowledge and engineering skills are used to resolve various threats to her team and to Earth
* Dr. Pierre Chang from Lost – An astrophysicist.
* Ravi Chakrabarti from iZombie – medical examiner for the Seattle PD. He has studied the unique biology of zombies and has made several attempts to develop a cure for the condition.
* Dr. Sheldon Cooper from The Big Bang Theory – A theoretical physicist at Caltech
* Professor Monty Corndog from The Aquabats / The Aquabats! Super Show! – An eccentric scientist and inventor whose chemical creations turned a group of ordinary men into superhero rock musicians who fight crime with the aide of The Professor's gadgets and contraptions
* Zefram Cochrane from Star Trek: The Original Series and Star Trek: First Contact – The inventor of the warp drive
* Beverly Crusher from Star Trek: The Next Generation – The chief medical officer of the Enterprise-D
* Data from Star Trek: The Next Generation – The second officer and chief operations officer of the Enterprise-D, but his duties covered that of a science officer
* Bill Davis from Family Affair – A civil engineer
* Davros from Doctor Who – Universal Genius from the planet Skaro and nemesis from the Doctor, he invented the Reality Bomb – a moon sized machine which creates a wavelength with the ability to cancel the electrical field that holds atoms together, he intended to use it to destroy all life in his own, and all other Universes in existence
* Jadzia Dax from Star Trek: Deep Space Nine – A science officer on Deep Space Nine
* Ezri Dax from Star Trek: Deep Space Nine – A counselor on Deep Space Nine
* Dr. Richard Daystrom from "The Ultimate Computer" episode of Star Trek: The Original Series – The inventor of the duotronic computer systems, the basic principles behind the computers on all Starfleet vessels.
* Dr. Linda Denman from H$_2$O: Just Add Water - A marine biologist who wanted to prove the existence of merpeople.
* The Doctor from Doctor Who – Asuper-intelligent alien who was educated as a scientist and uses his skills extensively in his adventures
* The Doctor from Star Trek: Voyager – Voyager's Emergency Medical Hologram
* Stephen "Steve" Douglas from My Three Sons) – An aeronautical engineer
* Dr. Amy Farrah Fowler from The Big Bang Theory – A neurobiologist who was played by real-life neuroscientist Mayim Bialik.
* Professor Sydney Fox from Relic Hunter – An archaeologist
* Stephen Franklin from Babylon 5 and Crusade
* Kaywinnet Lee Frye from Firefly – A mechanical engineer
* Dr. Goodfellow from Buck Rogers in the 25th Century
* Dr. Ross Geller from Friends – Paleontologist working at a museum in research and administration. Lecturer/Professor at NYU
* Dr. Horace Goodspeed from Lost – A mathematician
* Artemus Gordon from The Wild Wild West – A brainy complement to James West's brawn
* Max Hamilton from H$_2$O: Just Add Water
* Professor Roy Hinkley from Gilligan's Island – The respected de facto leader of the castaways and usually represents the only real continual hope of rescue. He can make anything out of bamboo and coconuts, but cannot find a way to either fix the S.S. Minnow or build a working boat.
* Dr. Leonard Hofstadter from The Big Bang Theory – An experimental physicist at Caltech
* Dr. Bunsen Honeydew from The Muppet Show – A scientist and founder of Muppet Labs.
* Paige Howard from Zoey 101
* Dr. Elias Huer from Buck Rogers – The chief scientist and inventor in the comic strip, movie serial and television series
* Dr. Daniel Jackson from Stargate and Stargate SG-1 – An archaeologist and linguist who figures out how to open the Stargate; his understanding of cultures and languages typically comes in handy when dealing with the bewildering array of cultures in the Stargate universe
* Jimmy the Robot from The Aquabats / The Aquabats! Super Show! – An android with advanced skills and knowledge in numerous areas of science and technology
* Professor Ko from Q18 Quantum Dice: Allegory of the Quantum [zh] - A quantum scientist
* Dr. Rajesh Koothrappali from The Big Bang Theory – An astrophysicist at Caltech
* Geordi La Forge from Star Trek: The Next Generation – A chief engineering officer of the Enterprise-D
* Li Wei from Q18 Quantum Dice: Allegory of the Quantum [zh] - The engineer of the quantum starlight programming
* Lu Chia-chia from Q18 Quantum Dice: Allegory of the Quantum [zh] - A rational engineer
* Angus "Mac" MacGyver from MacGyver – A secret agent who fights the forces of evil using his scientific and engineering knowledge to his advantage
* Quinn Mallory from Sliders – A graduate student who invents the transdimensional gateway
* Lewis McCartney from H$_2$O: Just Add Water
* Leonard McCoy from Star Trek: The Original Series – The chief medical officer of the Enterprise
* Dr. Rodney McKay from Stargate SG-1 and Stargate Atlantis – A brilliant but whiny astrophysicist who manages to save the lost city of Atlantis on a regular basis (and never lets anyone forget it)
* Miles O'Brien from Star Trek: Deep Space 9 – The chief operations officer on Deep Space Nine, which doubles as a chief engineer
* Walter O'Brien from Scorpion – 197 IQ genius, hacker, and leader of team Scorpion
* Dr. Juliet Parrish frm V – A scientist who becomes the principal leader of the resistance against the genocidal alien Visitors
* Quinn Pensky from Zoey 101 – A 13-year-old aspiring scientist, best known for her "Quinventions" that helps out her friends
* Phlox from Star Trek: Enterprise – The chief medical officer on the Enterprise-NX01
* Professor Bernard Quatermass (various TV series and movies)
* Dr. Bernadette Rostenkowski-Wolowitz from The Big Bang Theory – A microbiologist for a pharmaceutical company
* Hoshi Sato from Star Trek: Enterprise – A communication officer of the Enterprise-NX01 and inventor of the universal translator
* Abby Sciuto from NCIS – A forensic scientist for the Naval Criminal Investigative Service
* Montgomery "Scotty" Scott from Star Trek: The Original Series – The chief engineer of the Enterprise, often described as a miracle worker
* Dr. Richard Seaton from Skylark – A super-scientist
* Seven of Nine from Star Trek: Voyager – A Borg drone with no official rank or post, but due to her access to advanced Borg knowledge, she was used as an acting science officer on Voyager
* Dr. River Song from Doctor Who – An archeologist, adventurer, and companion of the Doctor
* Noonien Soong from Star Trek: The Next Generation – An inventor of the positronic brain, which makes intelligent androids possible
* Dr. Tolian Soran from Star Trek Generations – An El-Aurian scientist desperate to return to the Nexus
* Mr. Spock from Star Trek: The Original Series – A science officer and second-in-command of the Enterprise
* Dr. Mohinder Suresh from Heroes – A professor of genetics and parapsychology from India
* B'Elanna Torres from Star Trek: Voyager – The chief engineer of Voyager
* T'Pol from Star Trek: Enterprise – The second-in-command of the Enterprise-NX01, though the crew relied on her as an acting science officer as well
* Charles "Trip" Tucker III from Star Trek: Enterprise – The chief engineer of the Enterprise-NX01
* Mrs. Wakeman from My Life as a Teenage Robot – A scientist who is XJ-9's creator
* Dr. Rudy Wells from novel Cyborg by Martin Caidin; The Six Million Dollar Man, The Bionic Woman – A cyberneticist
* Howard Wolowitz from The Big Bang Theory – A aerospace engineer at Caltech

## In animated television

* Alador Blight from The Owl House - A workaholic engineer that uses a mixture of witchcraft and technology in order to craft weapons and mechanical bodyguards.
* Princess Bubblegum from Adventure Time – A beautiful princess who invents and creates the citizens of Candy Kingdom in the land of Ooo
* Minerva Campbell from Adventure Time – Finn's biological mother
* Sandy Cheeks from SpongeBob SquarePants - A major character who is one of SpongeBob's best friends.
* Aviva Corcovado from Wild Kratts – An engineer and inventor
* Dexter from Dexter's Laboratory – child genius who whips up dazzling, world-saving inventions in his secret laboratory
* Professor Hubert Farnsworth from Futurama – The creator of an atomic monster, various inventions, and the engines that allow space travel
* Professor Frink from The Simpsons – Springfield's greatest scientific and engineering mind
* Newton Gimmick from The Adventures of Teddy Ruxpin – An absent-minded inventor whose inventions do not always work, but who always comes through in the end
* Dr. Gross from Adventure Time – Cyborg
* Prince Gumball from Adventure Time – A gender-swapped version of Princess Bubblegum
* Gadget Hackwrench from Chip 'n Dale Rescue Rangers – A mouse tinkerer/scientist
* Franz Hopper fom Code Lyoko – A genius in quantum physics and computer programming responsible for the creation of the virtual reality Lyoko, malevolent A.I. XANA, and the advanced hardware that support both
* Dr. Fritz Huhnmorder from Robot Chicken – A scientist who revives a road-killed chicken with cybernetic technology and forces the chicken to watch various stop motion comedy sketches
* Kowalski from Penguins of Madagascar – team's scientist and inventor
* Doctor Krieger from Archer – The head of the ISIS applied research department
* Lisa Loud from The Loud House - The gifted member of the Loud family who invented different things.
* Professor Membrane from Invader Zim – A super-scientist; "the man without whom this world falls into chaos, and the inventor of Super Toast"
* Mametchi from Tamagotchi
* Jimmy Neutron from Jimmy Neutron: Boy Genius and The Adventures of Jimmy Neutron: Boy Genius – A self-proclaimed boy genius
* Perceptor from Transformers – An Autobot scientist
* Peridot from Steven Universe – A gem scientist and guardian of the crystal gems
* Stanford "Ford" Pines from Gravity Falls – author of the three journals and earned his Ph.D. in Backupsmore University
* Professor Porter from The Legend of Tarzan
* Doctor Prince from Adventure Time – A gender-swapped version of Doctor Princess
* Doctor Princess from Adventure Time – A medical official in Ooo
* Dr. Benton Quest from Jonny Quest
* Ratchet from Transformers series – A skilled Autobot medic; in the G1 Comics, he sacrifices himself to kill Megatron
* Rick Sanchez from Rick and Morty – A sociopathic, alcoholic but the smartest man of the universe who travels various dimensions with his grandson Morty.
* Asami Sato from The Legend of Korra – A trained engineer, skilled pilot and driver, and competent unarmed combatant; partner of Avatar Korra and CEO of Future Industries
* Sokka from Avatar: The Last Airbender – A self-taught engineer, inventor, and military strategist
* Twilight Sparkle from My Little Pony: Friendship is Magic
* Susan and Mary Test from Johnnt Test - twin sisters who develop all sorts of gadgets and chemicals, usually tested by Johnny with unexpected results.
* Professor Utonium from Powerpuff Girls – A father/scientist who created the Powerpuff Girls, among several other wacky things
* Dr. Thaddeus "Rusty" Venture from The Venture Bros. – A self proclaimed super-scientist who primarily re-purposes his father Jonas Venture's old inventions. Parody of Dr. Benton Quest.
* Dr. Nuvo Vindi from Star Wars: The Clone Wars
* Wheeljack from Transformers – Autobot engineer and inventor
* Hange Zoe from Attack on Titan – A quirky scientist in charge of studying titans and inventing new weapons for the Survey Corps.
* Doctor Zoidberg from Futurama – A lobster-like creature working as the company doctor for Planet Express

## In animated films

* Dr. Cockroach from Monsters vs. Aliens – A brilliant professor with the head, body and abilities of a cockroach
* Monsieur D'Arque from Beauty and the Beast
* Gru from the Despicable Me franchise - A former criminal genius turned good in the franchise
* Dr. Jumba Jookiba from Lilo & Stitch - An alien genius
* Mac from Chicken Run - A Scottish Chicken Scientist, helps other chickens escape the farm using aerodynamics, anatomy, mechanics.
* Megamind from Megamind - An alien genius who later became heroic
* Dr. Nefario from Despicable Me - Gru's scientist ally.
* Victor "Vector" Perkins from Despicable Me

## In comics and graphic novels
### DC Comics

* Barry Allen / Flash from The Flash – A police scientist and superhero
* Brainiac 5 (Legion of Super-Heroes) – reputed to have a brain exponentially more powerful than a normal human
* Jay Garrick / Flash from The Flash – A research scientist, superhero and founding member of the Justice Society of America
* Carter Hall / Hawkman – An archaeologist who has been reborn many times, using his knowledge acquired through centuries to aid him on his anthropological studies
* Ted Knight / Starman – An astronomer, expert scientist, and superhero
* Will Magnus – The creator of a team of advanced artificially-intelligent robots called the Metal Men
* Dr. Jon Osterman / Doctor Manhattan from Watchmen – A nuclear physicist transformed by accident into a godlike super-being. While publicized as a superhero, he functions as the ultimate weapon for the United States military when working as one of their sanctioned superheroes
* Ray Palmer / Atom – A professor of physics at Ivy University; able to shrink his body to varying degrees, even to sub-atomic level, and able to alter his mass to near infinite levels
* Doctor Poison – A Wonder Woman villain and a mad scientist who specializes in chemistry and poisons
* Alan Scott – An engineer and the first Green Lantern
* Angela Spica / Engineer II from The Authority
* Tom Strong – science hero
* Bruce Wayne / Batman – The world's greatest detective (reputedly), with incredible scientific knowledge and forensic and memory skills that are second to none

### Marvel Comics

* Dr. Bruce Banner / Hulk – A scientist who developed the "Gamma Bomb" for the US government. An accident at the site of a test led to Bruce Banner becoming the Hulk. For a long period after, while in the form of Bruce Banner, he looked for scientific ways to rid himself of the transformation.
* Forge – A mutant engineering genius.
* Dr. Henry (Hank) Philip McCoy / Beast – A world-renowned biochemist and mutant superhero who is a member of the X-Men
* Peter Parker / Spider-Man – A superhero with great knowledge of advanced sciences; now teaches at the high school he formerly attended. His father Richard has also been portrayed as a scientist and geneticist in the Ultimate Marvel comics as well as the films The Amazing Spider-Man and its sequel.
* Reed Richards / Mister Fantastic (Fantastic Four) – scientist and inventor, regarded as one of the most intelligent people on Earth, leader of the Fantastic Four
* Ted Sallis – A duplicator of the serum that created Captain America; transformed into The Man-Thing. Although he had serious problems with his personal ethics when it came to women and girls, he abandoned Operation Sulfer on moral grounds and elected to remain as Man-Thing rather than allow innocents to be killed by the demon Thog.
* Tony Stark / Iron Man – An industrialist and mechanical engineer of incredible ingenuity and inventive genius, whose technology to fight crime keeps him alive as well; he suffers from alcoholism
* Victor and Janet Stein – The founding members of Pride and the parents of Chase Stein.
* Professor Charles Francis Xavier / Professor X – The founder, mentor, and sometime leader of the X-Men
* Dr. Henry "Hank" Pym biochemist, discovers an unusual set of subatomic particles he labels "Pym particles". Entrapping these within two separate serums, he creates a size-altering formula and a reversal formula, testing them on himself. Becomes original Ant-Man.

### Other comics

* Adhemar from The Adventures of Nero – A child prodigy; professor in many different disciplines; Nobel Prize laureate; teaches at the university of Oxford and Cambridge
* Professor Barabas from Suske en Wiske – An expert in many inventions, including time travel
* Brainstorm from The Transformers: More than Meets the Eye – A scientific genius who invented time travel in order to save his best friend's husband, the consequences of which technically began the Autobot-Decepticon civil war.
* Professor Cuthbert Calculus from The Adventures of Tintin – A brilliant, if distracted, scientist; responsible for developing the first one-person submarine, the first ultrasonic destruction device, and the first white rose; leader of the first crewed lunar mission. Also very hard of hearing.
* Dilbert – A star engineer of the comic strip series Dilbert
* Dilton Doiley from the Archie Comics – A teenage inventor and scientific genius
* Donatello from Teenage Mutant Ninja Turtles – The most intelligent of the four Turtles, he builds a lot of advanced devices, often in the heat of battle
* Dr. Frankenollie from the Mickey Mouse short "Runaway Brain"
* Gyro Gearloose from the Donald Duck universe
* Jeremias Gobelijn from Jommeke – The self-declared "professor in everything"
* Agatha Heterodyne from Airship Entertainment and Girl Genius – An heiress to the political background and scientific understanding of the Heterodyne family
* Professor Kumulus from Piet Pienter en Bert Bibber
* Fran Madaraki from Franken Fran – An artificial human created by a biologist; like her creator, she possesses immense medical skills
* Helen B. Narbon from Narbonic – A mad geneticist with an odd fascination with gerbils.
* Professor Philip Mortimer from Blake and Mortimer – The main character, physicist and gentleman scholar
* Professor Snuffel from Piet Pienter en Bert Bibber
* Tilly Tailor - teen wearable technology engineer and leader of the SEWing Circle (Style Engineers Worldwide)
* Ludwig Von Drake from the Donald Duck universe – A professor of science and psychology
* Wally from Dilbert – A lazy and disillusioned engineer of the comic strip series in the Dilbert universe
* Dr. Hans Zarkov from Flash Gordon

## In anime and manga
### Individual scientist/engineers in anime and manga

* Lloyd Asplund from Code Geass – A Britannian scientist who designed the Lancelot Knightmare Frame, a bipedal, humanoid superweapon entrusted to Japanese pilot Suzaku Kururugi
* Professor Brown
* Bulma from Dragon Ball – The creator of the Dragon Radar and a time machine allowing Trunks to avert the conquest of the world by evil androids
* Heaven Canceller from A Certain Magical Index – A doctor and medical scientist
* Kiranin Colbock from Space Runaway Ideon – A member of a science academy
* Dr. Cinnamon from TwinBee – A genius scientist who is the creator of TwinBee and WinBee.
* Caesar Clown from One Piece – The former marine scientist and former partner of Doctor Vegapunk. He created mass destruction weapons and human experimentation, but was fired and arrested due to his unethical research methods.
* The Doctor from Hellsing – The lead scientist of Millennium who created the Nazi vampires and the catboy Schrödinger
* Professor Kozo Fuyutsuki from Neon Genesis Evangelion – The right-hand man to Supreme Commander Gendo Ikari and second in command of Nerv
* Szayelaporro Grantz fromBleach - An Arrancar scientist.
* Doctor Hogback from One Piece – The doctor of Gecko Moria's crew who modified dead bodies to create a zombie army with the help of his captain
* Jonathan Joestar from JoJo's Bizarre Adventure – Studied to be an archaeologist, but died before doing anything major.
* Harumi Kiyama from A Certain Scientific Railgun – The creator of the Level Upper
* Ri Kohran from Sakura Wars
* Jotaro Kujo from JoJo's Bizarre Adventure – An oceanographer, while unrelated to his role in the various plot arcs he appears in, Jotaro earns a doctorate in oceanography sometime during the summer of 1999 in the series' original timeline; dolphin and anchor motifs were added to his clothing designs to reflect his new occupation
* Dr. Emil Lang from Robotech – He was responsible for much of the Earth-based Robotechnology; briefly seen in the original series, he played a much larger role in the aborted series Robotech II: The Sentinels, which was adapted as a comic book series
* Professor Ochanomizu – The surrogate father of Osamu Tezuka's Astro Boy
* Manami Okuda from Assassination Classroom
* Tochiro Oyama from Captain Harlock – A designer and some say the soul of Harlock's spaceship Arcadia
* Dr. Tem Ray from Mobile Suit Gundam – The father of Amuro Ray; led the design team that created the RX-78 Gundam
* Dr. Aki Ross from Final Fantasy: The Spirits Within – A biologist vowing to stop the aliens that plague the Earth
* Shiro Sanada from Star Blazers – The chief technician or chief mechanic of the Space Battleship Yamato, called Sandor in Star Blazers
* Professor Noriyasu Seta from Love Hina
* Skuld from Oh My Goddess! – The goddess who has the ability to build robots and machines from scrap material
* James Ray Steam from Steamboy – A boy genius who helps his father and grandfather save Victorian London from a greedy corporation's superweapons
* Precia Testarossa from Magical Girl Lyrical Nanoha
* Wu Tomoki from JoJo's Bizarre Adventure – An orthopedic surgeon and cosmetic dermatologist employed at the T.G. University Hospital, notable for his research of the Locacaca fruit
* Doctor Vegapunk from One Piece – The leading scientist in the employment of the Marines. His work includes discovering the secrets and uses of Seastone, the secrets of how Devil Fruit powers work, how to get an item to "eat" a Devil Fruit, and other futuristic inventions.
* Hanji Zoe from Attack on Titan – The head scientist in the survey corps, performs experiments on captured titans hoping to find a new way to save humanity

## In video games
### Scientists in video games

* Dr. Alphys from Undertale – A stout Lizard monster, and Asgore's royal scientist; extremely timid; the creator of the robot Mettaton and the Amalgamates; has a crush on Undyne, captain of the Royal Guard
* Dr. Andonuts from EarthBound – The father of Jeff, one of the Chosen Four
* Rikako Asakura from Touhou Project – Titled "Scientist Searching for Dreams", she is one of the few people in Gensokyo to value using science over magic. While she still uses magic in order to enhance her science at times, she tries to refrain from using magic due to a natural distaste of it.
* Coco Bandicoot (Crash Bandicoot) - she is Crash Bandicoot's younger sister. She has a deep intelligence and a love of science, which makes her the opposite of her brother. He is an electronics engineer specializing in hacking, computer programming and machine building
* William Birkin from Resident Evil 2 – A microbiologist working for the pharmaceutical enterprise Umbrella Corporation; creator of the G-virus; he was wounded and injected himself with his G-virus, mutating him into a monster
* Dr. Bosconovitch from the Tekken series
* Ciel from Mega Man Zero – A young human scientist who awakens Zero in order to save the world
* Lucrecia Crescent from Final Fantasy VII – A Shinra scientist and lover of Vincent Valentine
* Penny Crygor from WarioWare - Dr. Crygor's granddaughter
* Dr. Casper Darling from Control - Head of Paranatural Research at the United States Federal Bureau of Control
* Pieter Van Eckhardt from Tomb Raider: The Angel of Darkness
* Dr. Gordon Freeman, Ph.D. from Half-Life – A theoretical physicist who fights a one-man battle against invading aliens, US Marines and Combine forces with a crowbar and other weapons; his associates are Drs. Isaac Kleiner, Eli Vance, Judith Mossman and Arne Magnusson
* Professor E. Gadd from the Nintendo video games
* Dr. Gast from Final Fantasy VII – The former head of the Shinra Company's science department; has a much stronger moral compass than his successor
* Dr. W.D. Gaster from Undertale – A former royal scientist who speaks in the Wingdings font
* Nicoletta "Nico" Goldstein from Devil May Cry - Creator of various robotic arms that the player can use when playing as Nero
* Catherine Elizabeth Halsey, MD, PhD from tje Halo series – scientist of the Office of Naval Intelligence, best known as the creator of the SPARTAN-II Program and Mjolnir Powered Assault Armor, for supervising the creation of the template for third-generation smart AI and creating Cortana
* Dr. Samuel Hayden from Doom – Head of the UAC, physicist.
* Hojo from Final Fantasy VII – Head of the Shinra Company's science department; a sociopathic, amoral bioengineer whose experiments drive the game's plot forward
* Kirin Jindosh from Dishonored 2 - Grand Inventor to Duke Luca Abele and founder of Jindosh Clockworks which created the Clockwork Soldiers and Clockwork Sentinels
* Cave Johnson from Portal 2 – The eccentric former owner of Aperture Science, and creator of the portal gun
* Plague Knight from Shovel Knight - A rouge member of the Order of No Quarter, tries to harvest their Essence for the Ultimate Potion to win over someone's heart.
* Dr. Krieger from Far Cry – A renowned scientist and creator/controller of the Trigens in the first Far Cry game
* The Love Lab scientists from Rhythm Heaven – A male and female scientist pass ingredients to each other to make love potions to the rhythm of the music
* Dr. Light from Mega Man – The creator of the revolutionary robot Mega Man
* Kurisu Makise from Steins;Gate – A famous Japanese neuroscientist who lives in the United States, builds a machine that allows the user's memories to be converted into data.
* Mei from Overwatch and Heroes of the Storm – A climatologist and one of the heroes in both games and comic series
* Moira from Overwatch – A geneticist and one of the playable heroes in the game
* Daro'Xen vas Moreh from Mass Effect 2 – A Quarian admiral and scientist who believes that the geth, a synthetic race created by the quarians, who subsequently rebelled and drove their masters from their homeworld, should be controlled by the quarians once again; Admiral Xen also performed surgery on her childhood toys, much to the quarian squadmate Tali'Zorah's disgust
* Neuron from City of Heroes
* Dr. Otto Wolfgang Ort-Meyer from Hitman – The creator of Agent 47 and other clone assassins
* Tobias Planck from Pirate Galaxy – Named after Max Planck, he is a theoretical physicist and field scientist with a parietal lobe 15% larger than average
* Miles "Tails" Prower from Sonic The Hedgehog
* Mordin Solus from Mass Effect 2 – A member of fictional alien species known as Salarians (who have fast metabolisms, talk fast, walk fast, and think fast); a brilliant biologist and a tech specialist
* Egon Stetmann from StarCraft II – The creator of the Mecha Swarm, paranoid, and prone to terrazine-induced hallucinations, he was once chief science adviser aboard the Hyperion.
* Dr. Yi Suchong from the Bioshock series – Ascientist in the city of Rapture, known for creating the Big Daddies, plasmids such as telekinesis and enrage, and helping to turn Jack into Frank Fontaine's "ace in the hole"
* Grimoire Valentine from Final Fantasy VII – A Shinra scientist and father of Vincent Valentine
* Wilhelm "Doktor" Voigt from Metal Gear Rising: Revengeance - Robotics engineer working for Maverick Security Consulting who assists the player in various ways throughout the game
* Reed Wahl from BioShock 2 – The co-founder of Rapture Central Computing, and co-inventor of the Thinker, main antagonist of Minerva's Den DLC
* Albert Wesker from Resident Evil – A microbiologist working for the pharmaceutical enterprise Umbrella and co-creator of the T-virus; he was killed in the first Resident Evil game by Tyrant T-002, a powerful biological weapon, and was resurrected with super-human powers after self-injecting the T-virus
* Dr. Zed from Borderlands – A "doctor"

### Engineers in video games

* Cid from Final Fantasy – Although there are many different individuals with the name of Cid in many different Final Fantasy games, most of them are some sort of engineer. His existence is a tradition on par with the Chocobo in the series.
* Isaac Clarke from Dead Space – A space engineer tasked with investigating the U.S.G. Ishimura, and later fighting the Necromorphs
* The Engineer from Deep Rock Galactic – Dwarven engineer and employee of the Deep Rock Galactic corporation.
* The Engineer from Team Fortress 2 – One of nine playable classes who is capable of building sentry guns for area denial and other constructions which may support other characters
* Otacon from Metal Gear – A designer of Metal Gear REX and ally of Solid Snake
* Rory Swann from StarCraft II – A New Yorker and engineer who runs the mothership of Jim Raynor
* Torbjörn from Overwatch – Swedish engineer and weapons designer, and a founding member of Overwatch.
* Shion Uzuki from Xenosaga – A "geeky engineer" and "unlikely heroine" who creates KOS-MOS, an "armored gynoid"

## Mad scientists

This section lists all the mad scientists in different media appearances:

### Mad scientists and evil geniuses in literature

* Otto Hantzen from Les Mystères de Demain from Paul Féval, fils and H. J. Magog – A German mad scientist, with female accomplice Hindu mystic Yogha, battles his former colleague Oronius from Mount Everest to Atlantis
* Victor Frankenstein from the novel Frankenstein by Mary Shelley – A scientist who stole body parts from graves and used them to create his monster
* Dr. Henry Jekyll (Strange Case of Dr Jekyll and Mr Hyde) – A scientist who searches for alteration of the human body and to separate the evil from the good which led to him developing the bad form of Edward Hyde.
* Mad scientists of Stanisław Lem, quite a few mad geniuses, many of whom strove to "inflict social panacea on entire populations", a part of Lem's philosophical analysis of social engineering.
* Dr. Moreau (The Island of Doctor Moreau) – A vivisectionist who has fled scandal to live on a remote island in the Pacific to pursue his research of perfecting his Beast Folk
* Professor Moriarty – The evil genius antagonist of Sherlock Holmes
* Dr. Julius No from Dr. No

### Mad scientists in live-action films

* Mr. Barron from Miss Peregrine's Home for Peculiar Children
* Dr. Simon Barsinister from Underdog - An adaption of the cartoon character who was scarred and cripped in an accident
* Nathan Bateman from Ex Machina
* Dr. René Emile Belloq (Raiders of the Lost Ark) – An adventuring archeologist and antagonist for Indiana Jones in targeting the Ark of the Covenant
* Dr. Ralph Benson from The Mad Doctor of Market Street
* Professor Gerard Beckert from Frostbite – A mad geneticist and Nazi World War II veteran creating genetically enhanced vampires out of the unsuspecting youth of a Norrland-town located above the Arctic Circle
* Dr. Theodore Bohmer from The Ghost of Frankenstein
* Dr. Paul Carruthers from The Devil Bat
* Dr. Phillip Channard from Hellbound: Hellraiser II
* Conal Cochran from Halloween III: Season of the Witch – He plans to resurrect macabre aspects of the Gaelic festival Samhain, which he connects to witchcraft
* Dr. Franz Edelmann from House of Dracula – A honourable doctor until he was transfused with the blood of Count Dracula. He then went insane and became a murderer.
* Dr. Evil from Austin Powers
* Casanova Frankenstein from Mystery Men - A criminal mastermind in Champion City
* Frederick Frankenstein from Young Frankenstein – The grandson of Victor Frankenstein, who at first is so embarrassed by his grandfather's deeds that he insists his name is pronounced "Fronkensteen," but eventually creates his own monster, equipped with an "enormous" Schwanzstücker.
* Henry Frankenstein from Frankenstein - The film's version of Victor Frankenstein.
* Dr. Frank N. Furter from The Rocky Horror Picture Show
* Dr. Golden Glory from The 5th Monkey - A deranged but brilliant Brazilian scientist who repeatedly attempts to torture monkeys in the hopes of discovering the cure for autism
* Dr. Gogol from Mad Love
* Dr. Lawrence Gordon from Saw and Saw 3D: The Final Chapter – An uncaring surgeon until he survived a "test" orchestrated by the Jigsaw Killer. After the experience changed his viewpoint on life, Gordon became Jigsaw's apprentice and began applying his medical skills to Jigsaw's traps which kidnapped victims were forced to endure. Following Jigsaw's death, Gordon became his successor.
* Dr. Josef Heiter from The Human Centipede (First Sequence) – Josef Mengele-esque surgeon known for his surgical atrocity he calls the "Human Centipede"
* Dr. Hoenneger (The Wolfman) – A German doctor who worked at an insane asylum and used medical torture to "treat" Lawrence Talbot's belief that he transformed into a werewolf every full moon
* Dr. Horrible from Dr. Horrible's Sing-Along Blog
* Dr. Ashley Kafka from The Amazing Spider-Man 2 – German doctor who experimented on the patients of the Ravencroft Institute for the Criminally Insane. He is a male version of the comic book character.
* John Kramer from Saw franchise – A former civil engineer who spends the last months of his life testing people's will to live by kidnapping and placing them in potentially deadly traps
* Dr. Nick Laslowicz from The Centrifuge Brain Project
* Dr. Mannering from Frankenstein Meets the Wolf Man
* Dr. Wolfe MacFarlane from The Body Snatcher
* Dr. Cal Meacham from This Island Earth – An earth scientist (a radio engineer in the novel) kidnapped to solve the problem of defending the planet Metaluna
* Dr. Harold Medford from Them! – He led the team that wiped out the giant ants
* Dr. Gustav Niemann from House of Frankenstein – A mad doctor who escaped prison for revenge, took over a horror carnival exhibit that included Count Dracula and later encountered Frankenstein's monster and the Wolf Man
* Philo from UHF
* Doctor Septimus Pretorius from Bride of Frankenstein – A mad doctor and Henry Frankenstein's teacher who followed in Henry Frankenstein's footsteps in creating living beings. He blackmailed Frankenstein into helping him to create a female companion for Frankenstein's monster
* Rotwang from Metropolis
* Dr. Shinzo Mafune from Terror of Mechagodzilla – A bitter oceanographer who had previously been ridiculed for his obsessive research into the brain patterns of sea creatures, he allies with the invading Black Hole Planet 3 Aliens, unleashing the mind-controlled kaiju Titanosaurus – whom he had personally discovered – to assist their newly-rebuilt Mechagodzilla.
* Dr. Carl Stoner from Sssssss - A delusional scientist attempting to create a method of transforming humans into snakes
* Dr. Strangelove from the film of the same name – A former Nazi scientist who was the scientific advisor to the President of the United States during the brink of apocalypse
* Dr. Alexander Thorkel from Dr. Cyclops
* Dr. Jane Tiptree from Carnosaur – A mad scientist who plans to recreate dinosaurs and destroy humanity
* Dr. Richard Vollin from The Raven
* Dr. Eric Vornoff from Bride of the Monster)
* Dr. Herbert West (Herbert West–Reanimator and Re-Animator)
* Peter Weyland from Prometheus
* Dr. Henry Wu from Jurassic Park, Jurassic World, and Jurassic World: Fallen Kingdom - The latter two movies had him creating hybrid dinosaurs for his clients
* Dr. XXX from The Mad Doctor animated film

### Mad scientists in live-action television

* Dr. Arthur Arden / Hans Grüper from American Horror Story: Asylum
* Walter Bishop from Fringe – A genius and literally mad scientist who was responsible for opening a doorway into another universe in order to save an alternate version of his son Peter from dying. His actions resulted in the gradual breakdown of both universes and inadvertently started a war between them
* Martin Brenner from Strange Things - He was the scientist who experimented on Eleven.
* Professor Roy Curien from House of the Dead 2
* Davros from Doctor Who - The creator of the Daleks.
* Dr. Laurence Erhardt from Mystery Science Theater 3000
* Dr. Clayton Forrester from Mystery Science Theater 3000
* TV's Frank from Mystery Science Theater 3000
* Kinga Forrester from Mystery Science Theater 3000
* Pearl Forrester from Mystery Science Theater 3000
* Dr. Benjamin Jeffcoat from My Secret Identity
* Dr. Loveless from The Wild Wild West
* The Master from Doctor Who - A renegade alien who seeks universal conquest.
* Masahiko Minami from Kamen Rider 555
* Dr. Jonathan Reiss from Lara Croft Tomb Raider: The Cradle of Life - A disease specialist who sought to obtain Pandora's box.
* Dr. Wilhelm Rolf - from Days of Our Lives
* Dr. Shrinker - from Doctor Shrinker

### Mad scientists in animated television

* Hugo A-Go-Go from Batfink - Batfink's most recurring enemy.
* Dr. Arkeville from The Transformers – A self-proclaimed evil genius who allies himself with the Decepticons
* Lord Boxman from OK K.O.! Let's Be Heroes – An evil robotics engineer and CEO of Boxmore.
* Professor Bug from The Backyardigans – A pseudo-steampunk mad scientist portrayed by Pablo who bugs all the robots in Mega City in the two-part episode "Robot Rampage"
* Professor Finbarr Calamitous from The Adventures of Jimmy Neutron: Boy Genius - A recurring enemy of Jimmy Neutron.
* Dr. Cerebral from Atomic Betty - A mad alien scientist, consisting of a brain with a face floating within a glass tank upon a mechanical body who seeks to control the universe and wipe out all organics due to a belief mechanical beings be more efficient.
* Dr. Claw from the Inspector Gadget series - The leader of MAD.
* Dr. Heinz Doofenshmirtz from Phineas and Ferb – A mad scientist whose goal is to take over the Tri-State Area
* Dr. Drakken from Kim Possible – A blue-skinned mad scientist determined to take over the world in order to prove his genius
* Miles Dredd from Max Steel – The main antagonist of Max Steel.
* Princess Entrapta from She-Ra: Princess of Power and She-Ra and the Princesses of Power - The Evil Horde's robotics engineer and inventor
* Dr. Flug from Villainous - An intelligent and inventive mad scientist who creates all the gadgets and machines that Black Hat attempts to sell.
* Mojo Jojo from Powerpuff Girls – A mad scientist chimpanzee that plots to take over the world and destroy the Powerpuff Girls. He was also Professor Utonium's former pet and partially responsible for the creation of the Powerpuff Girls
* Van Kleiss from Generator Rex – The main antagonist
* Mandark from Dexter's Laboratory – Dexter's rival, an evil genius who wants to destroy Dexter's laboratory and take over the world
* Mane-iac from My Little Pony: Friendship Is Magic – A mad scientist in chemical engineering, specializing in the production of detergents
* Marvin the Martian from Looney Tunes – A would-be planet conqueror
* Megatron from Transformers – The leader of the Decepticons.
* Dr. Alphonse Mephesto from South Park – A mad scientist who specializes in genetic engineering; creates strange creatures with his talents; also performs experiments ranging from simple DNA tests to creating a genetic clone of Stan Marsh for his son's science project
* Doctor Mindbender from G.I. Joe: Renegades – In this show, Doctor Mindbender is a mad young genius in charge of Cobra's secret Bio-Viper project
* Dr. Namba from Pokémon – An evil scientist who works for Team Rocket where he mostly oversees Cassidy and Butch.
* Plankton from SpongeBob SquarePants) – An evil genius who specializes in building robotic inventions, including his sidekick Karen.
* Vlad Plasmius from Danny Phantom – A half-ghost evil inventor
* Dr. Cinnamon J Scudworth from Clone High - A mad scientist who created all the clones of historic figures, employed by The Secret Board of Shadowy Figures
* Dr. Anton Sevarius from Gargoyles - A mad scientist, geneticist involved in several projects in the Gargoyles storyline. His most notable act is the creation of Talon and the Mutates.
* Jack Spicer from Xiaolin Showdown – A self-proclaimed evil boy genius
* Doctor Two-Brains from WordGirl
* Professor Venomous from OK K.O.! Let's Be Heroes – An international terrorist and evil inventor
* Dr. Weird from Aqua Teen Hunger Force – The smartest, madest, and scientistest scientist in the universe whose experiments often cause problems for the Aqua Teens.

### Mad scientists in animated films

* Buddy Pine / Syndrome from The Incredibles - Mr. Incredible's fan/aspiring sidekick-turned-supervillain who uses his scientific prowess to give himself enhanced abilities.
* Dr. Finkelstein from The Nightmare Before Christmas
* Victor "Vector" Perkins from Despicable Me

### Mad scientists in anime and manga

* Naoko Akagi from Neon Genesis Evangelion
* Ritsuko Akagi from Neon Genesis Evangelion – The daughter of Naoko Akagi
* Dr. Hiroshi Agasa from Case Closed – An absent-minded professor who invents several devices to help out Jimmy Kudo
* Bondrewd from Made in Abyss – White Whistle of ill repute, "Bondrewd the Novel" is in charge of Idofront, the Cave Riders' forward Operating Base in the fifth layer. He was the one responsible for several unethical experiments on children, including the one which transformed Nanachi and Mitty into Hollows.
* Dr. Hell from Mazinger Z - A mad scientist that is obsessed with taking over the world with his army of robotic monsters known as Mechanical Beast or Kikaiju.
* Senku Ishigami from Dr. Stone - A genius with a vast amount of scientific knowledge. He is able to invent various kinds of tools and gadgets in a short amount of time with ease. As a child, he designed and built a functioning miniature rocket ship. Senkuu also possesses an analytical mind, being able to correctly discern the situation he is in. Even in his pre-teens, he was intelligent and sharp-minded enough to create advanced machines.
* Mayuri Kurotsuchi from Bleach – A sadistic and cruel shinigami who uses his position as the leader of the Soul Society's Shinigami Research and Development Institute to conduct his experiments.
* Desty Nova from Battle Angel Alita – A wicked genius whose work is fueled by philosophy; highly skilled at nanotechnology
* Rintaro Okabe from Steins;Gate - an eccentric yet kind-hearted inventor who embraces the typical image of a mad scientist. His experiments lead to the invention of time travel.
* Orochimaru from Naruto – A shinobi obsessed with immortality and obtaining knowledge of all jutsu. He conducted many illegal and unethical experiments that resulted in him becoming a wanted criminal.
* Franken Stein from Soul Eater
* Kaolla Su from Love Hina – An exchange student who is the princess of the island of Molmol. She frequently invents dangerous devices and wants to turn her kingdom into a technological powerhouse that will conquer Japan.
* Professor Souichi Tomoe from the Sailor Moon franchise - The father of Hotaru Tomoe and the leader of Death Busters, used to be as a world-renowned scientist in field of genetic engineering and forced out of the scientific community of his unethical experiments, he sold his findings to companies and bought the entire Sankakusu District to continue his research to create "Super Beings". He vesselized one of the Daimon eggs: Gematoid to become hybrid by sold his soul to Master Pharaoh 90 and willfully discards his humanity and created a lot of Daimons while working to perfect the stability of Daimon/human hybribs.
* Daruma Ujiko from My Hero Academia – A mad scientist associated with the series' main antagonists, League of Villains.
* Kabuto Yakushi from Naruto – Orochimaru's assistant who takes part in many of his master's illegal experiments in addition to conducting his own, which include raising the dead.

### Mad scientists in comics
#### Mad scientists in DC Comics

* Anti-Monitor
* Dr. Tito Daka from the Batman serial
* Doctor Death – The first supervillain Batman ever faces, Doctor Death is a chemist and producer of biological weapons
* Dollmaker – A serial killer and insane surgeon who makes dolls out of human flesh
* Gorilla Grodd
* Professor Ivo – A DC Comics supervillain and creator of Amazo who is obsessed with immortality
* Lex Luthor (Superman films and DC Comics) – The scientific genius who is the nemesis of Superman. While the Pre-Crisis version had him as a mad scientist with his Earth-Two counterpart being Alexei Luthor, the Post-Crisis version is the CEO of LexCorp.
* Man-Bat
* Mr. Freeze
* Orca
* Doctor Poison – A Wonder Woman villain and a mad scientist who specializes in chemistry and poisons
* Poison Ivy from Batman – A supervillain scientist with an affinity towards plant life.
* Doctor Sivana – The world's wickedest scientist and arch-enemy of Captain Marvel
* Hugo Strange - A mad scientist who obsessed over finding out Batman's true identity.
* T. O. Morrow
* Ultra-Humanite
* Wizard / Carter from the Batman and Robin serial

#### Mad scientists in Marvel Comics

* Apocalypse
* Curt Connors – A college professor who created a formula to regrow his missing arm; turning himself into "The Lizard".
* Doctor Doom – An evil scientist, engineer, genius, conqueror; like Mister Fantastic, he is regarded as one of the most intelligent people on Earth, even though he is a villain
* Il Dottore from Genshin Impact (introduced in the webtoon) – a harbinger and scientist, known for his unethical experiments on children and co-workers.
* Doctor Octopus (Spider-Man 2 and Marvel Comics) – A narcissistic roboticist and nuclear physicist who was fused to his four mechanical tentacles; has a vendetta against Spider-Man
* Jackal - A college professor who has a vendetta against Spider-Man due to the death of his girlfriend Gwen Stacy, whom he secretly loved, created multiple clones of the hero as well as a clone of Gwen herself to attack and torment him and eventually turning himself into a jackal-like beast.
* Kang the Conqueror
* Leader
* Mandarin
* Mister Sinister
* MODOK
* Morbius - A scientist whose experiment with vampire bat DNA turned him into a pseudo-vampire.
* Norman Osborn (Spider-Man and Marvel Comics) - A billionaire CEO of Oscorp who is at times portrayed as a scientist with brilliant intellect and who crafts a Halloween-themed costume called Green Goblin while having developed a personality associated with it. Spider-Man's nemesis.
* Scarab (Captain America) - A mad scientist who is the alias of Dr. Cyrus Maldor.
* Bolivar Trask
* Vulture
* Baron Heinrich Zemo - A Nazi and archemy of Captain America.
* Arnim Zola (Captain America films and Marvel Comics) – former Nazi scientist who escaped death by transferring his consciousness into a mechanical body. In the present day, he is a member of the HYDRA terrorist organization

#### Mad scientists in other comics

* Dr. Jonathan Septimus from Blake and Mortimer – A mad scientist vengeful due to perceived slights by his colleagues, appears in The Yellow "M" and The Septimus Wave
* Joachim Sickbock from Tom Poes – A mad scientist who often proves to be a threat to the protagonists
* Baxter Stockman from Teenage Mutant Ninja Turtles) - A mad scientist and archenemy of the Teenage Mutant Ninja Turtles. Other media adaptions had him working for Shredder and the Foot Clan.
* Othar Tryggvassen from Girl Genius – A powerful "spark", or mad scientist, bent on destroying all sparks, including himself

### Mad scientists in video games

* Doctor Nitrus Brio from Crash Bandicoot – A timid and meek scientist who assisted Doctor Neo Cortex in the first game, often using beakers of chemicals.
* Doctor Neo Cortex from Crash Bandicoot – An evil doctor who is the creator and arch-enemy of franchise's titular hero Crash Bandicoot with an oversized head, who has plans to conquer the world, using Power Crystals.
* Dr. Crygor from WarioWare
* Dr. Daniel Dickens from Angels of Death - The main character's therapist.
* Victor Donovan from Dead or Alive – The main antagonist of Dead or Alive series.
* Dr. Ivo "Eggman" Robotnik (Sonic the Hedgehog) – A mad scientist who is the archenemy series' titular hero, Sonic the Hedgehog, specializes in robotics and other fields of engineering, who invents various kinds of aircraft, robots and vehicles in various sizes; he imprisoned animals in the inside of working robotic shells, and experimented with kinds of mutations. He aims to capture the Chaos Emeralds.
* Dr. "Mundo" Edmundo from League of Legends – A sociopath medical doctor who only specializes in one field: the study of the pain response and how to inflict pain;his experiments have caused him to take on a monstrous form reminiscent of Frankenstein's Monster and a deceptively dimwitted speech pattern; out of all the scientists in the game, Dr. Mundo stands out as the only one who is a danger to both himself and others, evident in his self experiments.
* Doctor N. Gin from Crash Bandicoot – A masochistic scientist who assists Neo Cortex in the second game onward.
* Alexandria Hypatia from Dishonored 2 - Chief Alchemist at the Addermire Institute who gains a separate serial killer personality after an experiment gone wrong
* GLaDOS/Caroline from Portal - The main antagonist of the Portal franchise. She was Cave Johnson's assistant, before taking over the facility.
* Professor Hojo from Final Fantasy VII – head of the Shinra Science Research Division. He infused his unborn child Sephiroth with Jenova cells to turn him into a super soldier, and in the present aids Jenova/Sephiroth's plans in the name of scientific research.
* Professor Von Kriplespac from Conker's Bad Fur Day
* Dr. M from Sly Cooper – He is a mandrill and was the brains of Sly's father's gang he felt he was being held back, so he set up a fortress on Kaine Island to break into the Cooper Vault and claim the wealth.
* The Medic from Team Fortress 2 – one of nine playable classes who rejects the Hippocratic Oath. He is able to heal other characters and make them invincible (by using Übercharge) for a limited time with his Medigun. He previously had a medical licence, but lost it due to misplacing a patient's skeleton.
* Professor Monkey-For-A-Head from the Earthworm Jim franchise
* Dr. Muto
* Dr. Nefarious from Ratchet and Clank – A recurring adversary to Ratchet, Clank and Captain Qwark.
* Rintarō Okabe / Kyōma Hōōin from Steins;Gate – A self proclaimed mad scientist in his Kyōma Hōōin persona (which in reality is taken from a television show he watched as a child).
* General Wilhelm "Deathshead" Strasse (Wolfenstein) - The major antagonist of the series who leads the Nazis research projects
* Vexen from Kingdom Hearts – A founding member of Organization XIII. A brilliant scientist who carries out research on various Organization projects. He was in charge of the Replica Program at Castle Oblivion, but someone disposed of him.
* Viktor from League of Legends - A scientist who replaced his body with a machine and wants to enhance the human race.
* Dr. Wily from Mega Man – The primary antagonist of the original Mega Man series.
* Yuri from Red Alert 2 and expansion pack – A Soviet psychic and founder of the Psychic Corps. During the Second World War, he took part in Stalin's secret project, whose aim was to create a mind control technology, and army which specialized in psychic warfare.

## Other

* Henry Emily from Five Nights at Freddy's - Henry was the creator of the springlock animatronics, and possibly the original four animatronics. He is business partners with William Afton and is the father of Charlie Emily and Sammy Emily.
* Dr. Baron von Kluckinstein from The Radioactive Chicken Heads
* Morgus the Magnificent - A horror host of late-night science fiction and horror movies and television shows that originated in the New Orleans, Louisiana market.
* Professor Nebulous from Nebulous – The leader of an eco-troubleshooting team
* Professor Jocelyn Peabody from Dan Dare – The scientific brains behind many of the team's most inventive ideas

## Teams of scientists/engineers

* A team of scientists who investigate a deadly disease in The Andromeda Strain
* Arcot, Wade and Morey – A group of scientist-inventors in science fiction stories by John W. Campbell
* The Baltimore Gun Club in From the Earth to the Moon – three of its wealthy members (Victor Barbicane, Stuyvesant Nicholl, Ben Sharpe) build a giant gun which launches an occupied capsule to the Moon
* Bunsen and Beaker in The Muppets
* The Challengers of the Unknown – Four scientific explorers
* Edward Elric and Alphonse Elric – To alchemist brothers who seek the legendary Philosopher's stone, and end up saving their country with their alchemical skills
* Eureka - A hidden-away town in Oregon where everyone, even the young children, are scientific geniuses.
* Forensic scientists who use their skills to solve crimes in CSI: Crime Scene Investigation, CSI: NY and CSI: Miami
* Ghostbusters – Most of the central characters (Peter Venkman, Raymond Stantz, Egon Spengler and Winston Zeddemore) are parapsychologists who battle ghosts and other supernatural menaces with equipment of their own design
* Global Dynamics from Eureka - A major research facility in the town of Eureka, where most of America's top-secret government experiments are conducted.
* The K-science team: Hong Kong Shatterdome (Newton Geiszler and Hermann Gottlieb) – heads of the kaiju science research team (Pacific Rim)
* The Kihara family of mad scientists are dedicated to the pursuit of science whatever the cost, in A Certain Magical Index. The individual members are often antagonists
* The Last Three of Venus – Venusian scientists and adversaries of Dan Dare
* The League of Extraordinary Gentlemen
* The Lone Gunmen – A group of ardent conspiracy theorists and computer hackers who frequently assist central X-Files characters Mulder and Scully, though they sometimes have their own adventures
* LOVEMUFFIN (short for League of Villainous Evildoers Maniacally United For Frightening Investments in Naughtiness) – A group of mad scientists in Phineas and Ferb that Dr. Heinz Doofenshmirtz is a member of.
* STUDY – A group of frustrated young adult scientists acting as antagonists in A Certain Scientific Railgun S
* The Speedwagon Foundation – group consisting of doctors and archaeologists founded by Robert E. O. Speedwagon somewhere between the story arcs of Phantom Blood and Battle Tendency in JoJo's Bizarre Adventure; extremely knowledgeable on Stands, Pillar Men and Dio
* Unorthodox Engineers – A misfit bunch of engineers who solve problems of alien technology/weird planets in the future