# List of Lopez Tonight episodes

This is a list of episodes of Lopez Tonight, which aired from November 9, 2009, to August 12, 2011, on TBS.

## 2009
### November

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1 | November 9, 2009 (2009-11-09) | Ellen DeGeneres, Eva Longoria, Kobe Bryant | Carlos Santana ("Oye Como Va"), ("The World is Rated X") |
| Audience Game ||||
| 2 | November 10, 2009 (2009-11-10) | Jamie Foxx, Marc Anthony | Marc Anthony ("Tu Amor Me Hace Bien") |
| Corporate Sponsor for the show, Grown-up Play Date ||||
| 3 | November 11, 2009 (2009-11-11) | Queen Latifah, Michael Bearden | Michael Jackson's Band ("Man in the Mirror") |
| Creepy Little White Girl ||||
| 4 | November 12, 2009 (2009-11-12) | Larry David, Lisa Lampanelli | Jay Sean ("Down"), Birdman ("Written On Her") |
| Larry David's DNA Test ||||
| 5 | November 16, 2009 (2009-11-16) | Charlie Sheen, Demi Lovato | Slash |
| Slash and Tommy Organ Guitar Duel ||||
| 6 | November 17, 2009 (2009-11-17) | Andy García, The Real Housewives of Orange County | Justin Bieber ("One Time") |
| Bullet Wound/Not a Bullet Wound ||||
| 7 | November 18, 2009 (2009-11-18) | Oscar De La Hoya, Paul Mooney | Amerie ("Heard 'Em All") |
| Chola Girl Makeover ||||
| 8 | November 19, 2009 (2009-11-19) | Ted Danson, Bill Engvall | Orianthi ("According To You") |
| Creepy Little White Girl, Dear George ||||
| 9 | November 23, 2009 (2009-11-23) | Eva Mendes, Craig Robinson | Mary J. Blige ("I Am") |
| British Versions of American Posters ||||
| 10 | November 24, 2009 (2009-11-24) | Sandra Bullock, Derek Luke | Shakira ("Give It Up To Me") |
| Sandra Bullock Chola Makeover ||||
| 11 | November 25, 2009 (2009-11-25) | Arsenio Hall | Jo Koy |
| Black Barbie Ain't Nothing! ||||
| 12 | November 26, 2009 (2009-11-26) | Taylor Lautner, Kristin Cavallari | LMFAO ("La La La") |
| "Twilight" - Make Me Like It!, The Hills: 2012 ||||
| 13 | November 30, 2009 (2009-11-30) | Katey Sagal, Joanna Krupa | David Guetta Ft. Akon ("Sexy Chick") |
| Tiger Woods is in Trouble, Lopez Tonight Dance Competition ||||

### December

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 14 | December 1, 2009 (2009-12-01) | Jessica Alba, Columbus Short | The Bravery ("Slow Poison") |
| Creepy Little White Girl, Jessica Alba's DNA Test, Celebrity Endorsements ||||
| 15 | December 2, 2009 (2009-12-02) | Taye Diggs, Kaley Cuoco | Ruben Paul (Comedian) |
| Bullet Wound/Not a Bullet Wound, Apologies and Retractions ||||
| 16 | December 3, 2009 (2009-12-03) | Laurence Fishburne, Olivia Munn | Los Lobos ("Good Morning Aztlán") |
| Stump the Dancer ||||
| 17 | December 7, 2009 (2009-12-07) | Kathy Griffin, Rico Rodriguez | Sean Paul ("Hold My Hand") |
| Welcome to Your 15 Minutes with Kato Kaelin, Bullet Wound/Not a Bullet Wound ||||
| 18 | December 8, 2009 (2009-12-08) | Clint Eastwood, Jane Lynch | Dierks Bentley Ft. Patty Griffin ("Beautiful World"), Overtone (musical group) |
| Grand Torino Re-Edit, Make Me cool ||||
| 19 | December 9, 2009 (2009-12-09) | Cedric The Entertainer | Morrissey ("Don't Make Fun Of Daddy's Voice") |
| Dear George ||||
| 20 | December 10, 2009 (2009-12-10) | Hilary Duff, Scott Bakula | Rudy Moreno (Comedian) |
| Snoop Dogg & George Sell Brownies, "What the Hell is It?" ||||
| 21 | December 14, 2009 (2009-12-14) | Mark Harmon, 50 Cent | 50 Cent ("Baby by Me"), ("Do You Think About Me") |
| Regrettable Celebrity Phone Messages, The "Thuggie" ||||
| 22 | December 15, 2009 (2009-12-15) | George Lopez show reunion Belita Moreno, Constance Marie, Valente Rodriguez, Masiela Lusha, Luis Armand Garcia, Aimee Garcia | War ("Low Rider") |
| Creepy Little Sitcom Mom, Everybody Dance!, George Lopez Finale ||||
| 23 | December 16, 2009 (2009-12-16) | Mariah Carey, David Beckham | Mariah Carey ("Obsessed") |
| Style It Like Beckham!, George's DNA Test ||||
| 24 | December 17, 2009 (2009-12-17) | Ray Romano, Lake Bell, Cast Of Jersey Shore | Mariah Carey ("It's A Wrap") |
| Ray's Driving Technique ||||

## 2010
### January

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 25 | January 11, 2010 (2010-01-11) | Jackie Chan, Kesha | Kesha ("Tik Tok") |
| The Goatee Awards, Creepy Little White Girl, Tiger Woods Magazine Covers ||||
| 26 | January 12, 2010 (2010-01-12) | Jennifer Love Hewitt, Pitbull | Pitbull ("Shut It Down") |
| Goatee Political Ad, "Avatar" Chola Makeover ||||
| 27 | January 13, 2010 (2010-01-13) | Charles Barkley, Carrie Ann Inaba | N/A |
| Charles Barkley DNA Results, Obama Billboards, Sh#%t My Dad Says... ||||
| 28 | January 14, 2010 (2010-01-14) | Snoop Dogg, Saoirse Ronan | Snoop Dogg ("I Wanna Rock"), Cypress Hill ("Insane in the Brain") |
| Celebrity GPS, Snoop's DNA Results ||||
| 29 | January 18, 2010 (2010-01-18) | Amber Valletta, Mark Valley, Jennifer Lopez, and Christian Lander | N/A |
| Jennifer Lopez Hijacks Lopez Tonight, Vajazzled Vajayjay Crisis, George Interviews Mark McGwire ||||
| 30 | January 19, 2010 (2010-01-19) | Brendan Fraser, Khloé Kardashian, Kim Kardashian | N/A |
| Screaming Goat Spanglish Lesson, Whip It Out ||||
| 31 | January 20, 2010 (2010-01-20) | Tyrese Gibson, Betty White | Hannibal Buress (Comedian) |
| Chihuahua Rescue ||||
| 32 | January 21, 2010 (2010-01-21) | Samuel L. Jackson, Omarion | Omarion ("I Get It In") |
| Bullet Wound/Not a Bullet Wound ||||
| 33 | January 25, 2010 (2010-01-25) | Cheech & Chong, Regina King | Train ("Hey, Soul Sister") |
| Creepy Little White Girl With Cheech & Chong ||||
| 34 | January 26, 2010 (2010-01-26) | Sofía Vergara, James Van Der Beek | Jamie Kennedy (Comedian) |
| Ode to George's Goatee ||||
| 35 | January 27, 2010 (2010-01-27) | Kristen Bell, Charlie Wilson | Charlie Wilson ("There Goes My Baby") |
| Story Time with George, All-American Basketball League ||||
| 36 | January 28, 2010 (2010-01-28) | Ludacris, Elisha Cuthbert | David Guetta, Kelly Rowland ("When Love Takes Over") |
| Simpler Times With Ludacris ||||

### February

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 37 | February 1, 2010 (2010-02-01) | Giovanni Ribisi, Jessica Capshaw | Iyaz ("Replay") |
| 38 | February 2, 2010 (2010-02-02) | Jon Heder | Russell Peters (Comedian) |
| 39 | February 3, 2010 (2010-02-03) | Billy Zane, Brandon T. Jackson | Fabolous ("Throw It in the Bag") |
| 40 | February 4, 2010 (2010-02-04) | Christian Slater, Alessandra Torresani | Matt Morris ("Love") |
| 41 | February 8, 2010 (2010-02-08) | Jamie Foxx and Garry Marshall | N/A |
| 42 | February 9, 2010 (2010-02-09) | Topher Grace, Jewel | Jewel ("Stay Here Forever") |
| 43 | February 10, 2010 (2010-02-10) | Ashton Kutcher, Emma Roberts, Carter Jenkins | N/A |
| 44 | February 11, 2010 (2010-02-11) | Jennifer Garner, Héctor Elizondo | Steel Magnolia ("Keep on Lovin' You") |

### March

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 45 | March 1, 2010 (2010-03-01) | Dax Shepard, Nicole Eggert, Julia Mancuso | New Boyz |
| 46 | March 2, 2010 (2010-03-02) | Tracey Ullman | Bret Michaels |
| 47 | March 3, 2010 (2010-03-03) | Mario Lopez, Anjelah Johnson | T-Pain |
| 48 | March 4, 2010 (2010-03-04) | Seann William Scott, Andrew Dice Clay, Shaun White | N/A |
| 49 | March 8, 2010 (2010-03-08) | Evan Lysacek, Don Cheadle, AnnaLynne McCord, J. Alexander | N/A |
| 50 | March 9, 2010 (2010-03-09) | Freddie Prinze, Jr., Stone Cold Steve Austin, Alonzo Mourning | N/A |
| 51 | March 10, 2010 (2010-03-10) | Lenny Kravitz, Khloé Kardashian, Lamar Odom | Emilio Estefan |
| 52 | March 11, 2010 (2010-03-11) | Ozzy Osbourne, Kendra Wilkinson, Hank Baskett, Alonzo Mourning | N/A |
| 53 | March 15, 2010 (2010-03-15) | Shannen Doherty, Jessica Szohr, Louie Psihoyos | Jason DeRulo |
| 54 | March 16, 2010 (2010-03-16) | Dominic Monaghan, Kat Von D | Joe Bonamassa (guitarist) |
| 55 | March 17, 2010 (2010-03-17) | Wanda Sykes, Peter Facinelli | Loni Love (comedian) |
| 56 | March 18, 2010 (2010-03-18) | Andy García, Lance Gross, Johnny Weir | Lucrecia |
| 57 | March 22, 2010 (2010-03-22) | Dakota Fanning, Gene Simmons | Boys Like Girls ("Heart Heart Heartbreak") |
| 58 | March 23, 2010 (2010-03-23) | David Arquette, Chris Jericho | Trey Songz ("Say Aah") |
| 59 | March 24, 2010 (2010-03-24) | Eva Longoria, Sinbad | Eric Andre |
| 60 | March 25, 2010 (2010-03-25) | Chad Ochocinco, Johnny Weir | N/A |
| 61 | March 29, 2010 (2010-03-29) | Snoop Dogg, Annie Wersching | Foreigner ("Feels Like the First Time", "Hot Blooded") |
| 62 | March 30, 2010 (2010-03-30) | Clark Duke, Ludacris | N/A |
| 63 | March 31, 2010 (2010-03-31) | Omar Epps, Wendy Williams | Johnny Sanchez (comedian) |

### April

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 64 | April 1, 2010 (2010-04-01) | Usher, Ron Artest | N/A |
| 65 | April 5, 2010 (2010-04-05) | John Corbett, Nicole Scherzinger, Steve Lyons, Mark Littell | N/A |
| 66 | April 6, 2010 (2010-04-06) | Rod Blagojevich, Brandy, Ray J. | Saleem Mohammed (comedian) |
| 67 | April 7, 2010 (2010-04-07) | Taraji Henson, Bruno Tonioli | George Wallace (comedian) |
| 68 | April 8, 2010 (2010-04-08) | Zachary Levi | Slash |
| 69 | April 12, 2010 (2010-04-12) | Oscar De La Hoya, Shane Mosley | Chris Rock (comedian) |
| 70 | April 13, 2010 (2010-04-13) | Benjamin Bratt, Audrina Partridge | Bryan Kellen (comedian) |
| 71 | April 14, 2010 (2010-04-14) | Luke Wilson, Monica | N/A |
| 72 | April 15, 2010 (2010-04-15) | James Marsden, Reggie Miller | N/A |
| 73 | April 19, 2010 (2010-04-19) | Kara DioGuardi, Cheech and Chong | Jason Reeves |
| 74 | April 20, 2010 (2010-04-20) | Brendan Fraser, Angela Kinsey, Jason Aldean | N/A |
| 75 | April 21, 2010 (2010-04-21) | Zoe Saldana, Chris Evans | Lowell Sanders (comedian) |
| 76 | April 22, 2010 (2010-04-22) | Jennifer Lopez, Ken Jeong | Ozomatli |

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 77 | May 17, 2010 (2010-05-17) | Donald Trump, Julie Bowen | Weezer ("Can't Stop Partying") |
| 78 | May 18, 2010 (2010-05-18) | Common, Jorge Garcia, Bobby Slayton | N/A |
| 79 | May 19, 2010 (2010-05-19) | Chris Noth, Chilli | Allison Iraheta |
| 80 | May 20, 2010 (2010-05-20) | Ryan Phillippe, Niecy Nash, Mario Lopez | N/A |
| 81 | May 24, 2010 (2010-05-24) | Randy Jackson, Monica Potter | Paper Tongues |
| 82 | May 25, 2010 (2010-05-25) | Dennis Quaid, Penn and Teller | N/A |
| 83 | May 26, 2010 (2010-05-26) | Nick Cannon | Toni Braxton |
| 84 | May 27, 2010 (2010-05-27) | Ben Kingsley, Bret Michaels | Janelle Monáe |
| 85 | May 31, 2010 (2010-05-31) | Drew Carey, Marisa Miller | Mike Posner |

### June

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 86 | June 1, 2010 (2010-06-01) | Adrien Brody, Terry Crews | Hot Chelle Rae |
| 87 | June 2, 2010 (2010-06-02) | Jimmy Smits, Cat Deeley, Charlie Murphy | N/A |
| 88 | June 3, 2010 (2010-06-03) | Jonah Hill | Peter Frampton |
| 89 | June 7, 2010 (2010-06-07) | Russell Brand, Amber Riley | Usher |
| 90 | June 8, 2010 (2010-06-08) | Eric Stonestreet | Hanson |
| 91 | June 9, 2010 (2010-06-09) | Alfre Woodard | Ice Cube ("I Rep That West") |
| 92 | June 10, 2010 (2010-06-10) | Bryan Cranston | Lil Jon (featuring LMFAO) |
| 93 | June 14, 2010 (2010-06-14) | Liam Neeson, Bradley Cooper, Sharlto Copley, Quinton "Rampage" Jackson | N/A |
| 94 | June 15, 2010 (2010-06-15) | Tim Allen, Padma Lakshmi, Irvin Mayfield, Jim Florentine | N/A |
| 95 | June 16, 2010 (2010-06-16) | Jaden Smith, Jackie Chan, Taraji P. Henson | N/A |
| 96 | June 17, 2010 (2010-06-17) | Rob Schneider, Mel B. | Crash Kings |
| 97 | June 21, 2010 (2010-06-21) | Sharon Osbourne, Jillian Michaels | Ozzy Osbourne |
| 98 | June 22, 2010 (2010-06-22) | Helen Mirren, Cedric the Entertainer, Ron Artest | N/A |
| 99 | June 23, 2010 (2010-06-23) | Bill Cosby, Blair Underwood, Pau Gasol | Kid 'n Play |
| 100 | June 24, 2010 (2010-06-24) | Kobe Bryant, Louis C.K. | N/A |
| 101 | June 28, 2010 (2010-06-28) | Jada Pinkett Smith, Jerry Ferrara | Aventura |
| 102 | June 29, 2010 (2010-06-29) | Salma Hayek, Charlie Bewley, Booboo Stewart | N/A |
| 103 | June 30, 2010 (2010-06-30) | Kristen Stewart, Julia Jones, Billy Burke | Cee-Lo Green |

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 104 | July 1, 2010 (2010-07-01) | Laurence Fishburne, Peter Facinelli, Elizabeth Reaser | N/A |
| Spotlight on the stage show "In the Heights" ||||
| 105 | July 12, 2010 (2010-07-12) | Kathy Griffin, The Situation, Vinny Guadagnino, Pauly D, Nicole "Snooki" Polizzi, Ronnie Magro, Sammi Giancola, JWoww, Angelina Pivarnick | N/A |
| 106 | July 13, 2010 (2010-07-13) | Kellan Lutz, Missy Peregrym | Clay Walker |
| 107 | July 14, 2010 (2010-07-14) | Vivica A. Fox, Booker Forte' | Big Boi ("Follow Us") |
| 108 | July 15, 2010 (2010-07-15) | Jeremy Piven, Terrell Owens | Lifehouse ("All In") |
| 109 | July 19, 2010 (2010-07-19) | Nicolas Cage, Dania Ramirez, Shorty Rossi | N/A |
| 110 | July 20, 2010 (2010-07-20) | Seth Green, Ali Fedotowsky | Travie McCoy, Bruno Mars ("Billionaire") |
| 111 | July 21, 2010 (2010-07-21) | America Ferrera, Holly Robinson Peete, Tommy Davidson | N/A |
| 112 | July 22, 2010 (2010-07-22) | Tiffani Thiessen | Enrique Iglesias, Pitbull |
| 113 | July 26, 2010 (2010-07-26) | Selena Gomez, Wilmer Valderrama, Rob Schneider | N/A |
| 114 | July 27, 2010 (2010-07-27) | Steve Carell, Maggie Q. | Backstreet Boys ("If I Knew Then") |
| 115 | July 28, 2010 (2010-07-28) | Diddy, Tony Robbins | Diddy-Dirty Money, Rick Ross ("Hello Good Morning") |
| 116 | July 29, 2010 (2010-07-29) | Zac Efron | N/A |

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 117 | August 2, 2010 (2010-08-02) | Jim Parsons, Tricia Helfer | Street Sweeper Social Club |
| 118 | August 3, 2010 (2010-08-03) | Luke Wilson, Margaret Cho | Billy Ray Cyrus |
| 119 | August 4, 2010 (2010-08-04) | T.I., Idris Elba, Michael Ealy, Taryn Terrell | N/A |
| 120 | August 5, 2010 (2010-08-05) | Will Ferrell, Elisabeth Moss | Flo Rida |
| 121 | August 9, 2010 (2010-08-09) | Eva Mendes, Josh Hutcherson, Dolph Ziggler | Har Mar Superstar |
| 122 | August 10, 2010 (2010-08-10) | Anna Paquin, Randy Orton, R-Truth | N/A |
| 123 | August 11, 2010 (2010-08-11) | Mark Wahlberg, Bill Bellamy, David Otunga | N/A |
| 124 | August 12, 2010 (2010-08-12) | Gordon Ramsay, Vienna Girardi, The Miz | N/A |
| 125 | August 16, 2010 (2010-08-16) | Jason Statham, Aubrey Plaza | Wolfmother |
| 126 | August 17, 2010 (2010-08-17) | Dylan McDermott, Kat Von D, Meat Loaf | N/A |
| 127 | August 18, 2010 (2010-08-18) | Bow Wow, Lisa Edelstein, Caroline Manzo, Teresa Giudice | tWitch |
| 128 | August 19, 2010 (2010-08-19) | Michelle Rodriguez | Ted Nugent |
| 129 | August 23, 2010 (2010-08-23) | Justin Long, Michael Strahan | Los Lobos |
| 130 | August 24, 2010 (2010-08-24) | Jason Sudeikis, Kim Kardashian, Kourtney Kardashian | Korn ("Let the Guilt Go") |
| 131 | August 25, 2010 (2010-08-25) | Drew Barrymore | Fantasia |
| 132 | August 26, 2010 (2010-08-26) | Christina Applegate, Charlie Day | Lynyrd Skynyrd |

### September

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 133 | September 13, 2010 (2010-09-13) | Snoop Dogg, Bethenny Frankel | Goo Goo Dolls |
| 134 | September 14, 2010 (2010-09-14) | Ken Jeong, Audrina Partridge | Enrique Iglesias, Juan Luis Guerra |
| 135 | September 15, 2010 (2010-09-15) | Danny DeVito, Carmelo Anthony, La La, Chris Spencer | N/A |
| 136 | September 16, 2010 (2010-09-16) | Thomas Jane, Tim Gunn | Devo |
| 137 | September 20, 2010 (2010-09-20) | Eric Dane, Cloris Leachman | Daughtry |
| 138 | September 21, 2010 (2010-09-21) | Kevin Nealon, Kaitlin Olson | Michael Franti, Spearhead |
| 139 | September 22, 2010 (2010-09-22) | Anthony Anderson, Morgan Spurlock | Carlos Santana, India.Arie |
| 140 | September 23, 2010 (2010-09-23) | Kevin Connolly, The Situation, Rob Schneider | N/A |
| 141 | September 27, 2010 (2010-09-27) | LL Cool J, Kelly Osbourne | Santana, Nas |
| 142 | September 28, 2010 (2010-09-28) | Rob Morrow, Minka Kelly, Al Madrigal | N/A |
| 143 | September 29, 2010 (2010-09-29) | Magic Johnson, Sara Ramirez | Far East Movement |
| 144 | September 30, 2010 (2010-09-30) | Tom Bergeron | Seal |

### October

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 145 | October 18, 2010 (2010-10-18) | Shakira | Neon Trees |
| 146 | October 19, 2010 (2010-10-19) | Johnny Knoxville, Bam Margera, Steve-O, Chris Pontius, Whitney Cummings | N/A |
| 147 | October 20, 2010 (2010-10-20) | Eva Longoria Parker | John Legend |
| 148 | October 21, 2010 (2010-10-21) | Jeff Foxworthy, Chris Webber | N/A |
| 149 | October 25, 2010 (2010-10-25) | Bryce Dallas Howard, Criss Angel | N/A |
| 150 | October 26, 2010 (2010-10-26) | Bill Maher, Lauren Conrad | Taio Cruz |
| 151 | October 27, 2010 (2010-10-27) | Jon Cryer, Patti Stanger | Sean Kingston |
| 152 | October 28, 2010 (2010-10-28) | Jenny McCarthy, Eric Balfour | Allstar Weekend |

### November

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 153 | November 1, 2010 (2010-11-01) | Kathy Griffin, Simon Helberg | OneRepublic |
| 154 | November 2, 2010 (2010-11-02) | Mariah Carey, Judah Friedlander, Jon Lajoie | N/A |
| 155 | November 3, 2010 (2010-11-03) | William Shatner, Atticus Shaffer | Soulja Boy |
| 156 | November 4, 2010 (2010-11-04) | Andy Richter, Katie Cassidy | Good Charlotte |
| 157 | November 9, 2010 (2010-11-09) | Janet Jackson, Antoine Dodson | Rooney |
| 158 | November 10, 2010 (2010-11-10) | Jamie Foxx, Jayma Mays, Freddy Sanchez | N/A |
| 159 | November 11, 2010 (2010-11-11) | Howie Mandel, Juliette Lewis | KT Tunstall |
| 160 | November 12, 2010 (2010-11-12) | Denzel Washington, Hilary Duff, Russell Peters | N/A |
| 161 | November 16, 2010 (2010-11-16) | Manny Pacquiao | Sheryl Crow |
| 162 | November 17, 2010 (2010-11-17) | Kendra Wilkinson | Selena Gomez |
| 163 | November 18, 2010 (2010-11-18) | Carrie Ann Inaba, Nina Dobrev | JabbaWockeeZ |
| 164 | November 19, 2010 (2010-11-19) | Michael Chiklis, Miranda Cosgrove, Neal Brennan | N/A |
| 165 | November 23, 2010 (2010-11-23) | Kris Jenner, Tom Felton | Ne-Yo |
| 166 | November 24, 2010 (2010-11-24) | David Arquette, Ashley Greene, Billy Bretherton | N/A |
| 167 | November 25, 2010 (2010-11-25) | Billy Bob Thornton; Kunal Nayyar | Ice Cube |
| 168 | November 26, 2010 (2010-11-26) | Dwayne Johnson, Katie Cassidy, Felipe Esparza | N/A |
| 169 | November 30, 2010 (2010-11-30) | Zachary Levi, Perez Hilton | 3OH!3 |

### December

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 170 | December 1, 2010 (2010-12-01) | Bill Cosby, Angela Kinsey | Atomic Tom |
| 171 | December 2, 2010 (2010-12-02) | Charles Barkley, Brandy | Cee Lo Green |
| 172 | December 3, 2010 (2010-12-03) | Mario Lopez, Kathryn Hahn, Chris D'Elia | N/A |
| 173 | December 7, 2010 (2010-12-07) | Khloe Kardashian, Jo Frost, | Nicki Minaj |
| 174 | December 8, 2010 (2010-12-08) | Bob Saget, NeNe Leakes | Keri Hilson |
| 175 | December 9, 2010 (2010-12-09) | Alan Cumming, Chris D'Elia | N/A |
| 176 | December 10, 2010 (2010-12-10) | Steve Harvey | The 88 |
| 177 | December 14, 2010 (2010-12-14) | Eric Stonestreet, J.B. Smoove, Dov Davidoff | N/A |
| 178 | December 15, 2010 (2010-12-15) | Anna Faris, Apolo Anton Ohno | Natasha Bedingfield |
| 179 | December 16, 2010 (2010-12-16) | Mila Kunis, Drew Pinsky | Chrisette Michele |
| 180 | December 17, 2010 (2010-12-17) | Justin Timberlake, Stephen Dorff | Ciara |
| 181 | December 21, 2010 (2010-12-21) | Xzibit | Cirque du Soleil |
| 182 | December 22, 2010 (2010-12-22) | Gene Simmons, Scott Bakula | Bettye LaVette |
| 183 | December 23, 2010 (2010-12-23) | Ron Artest, Deon Cole | will.i.am |
| 184 | December 24, 2010 (2010-12-24) | Jack Black, Hailee Steinfeld | Filter |

## 2011
### January

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 185 | January 11, 2011 (2011-01-11) | Lauren Graham, Will Sasso | Plain White T's ("Rhythm of Love") |
| 186 | January 12, 2011 (2011-01-12) | Jesse Tyler Ferguson, Mary Lynn Rajskub, Maz Jobrani | N/A |
| 187 | January 13, 2011 (2011-01-13) | Roseanne Barr, Danny Pudi | El DeBarge, Faith Evans ("Lay with You") |
| 188 | January 14, 2011 (2011-01-14) | David Duchovny, Kimora Lee Simmons | Saving Abel |
| 189 | January 18, 2011 (2011-01-18) | Seth Rogen, Ginnifer Goodwin | Sick Puppies ("Maybe") |
| 190 | January 19, 2011 (2011-01-19) | William H. Macy, Camille Grammer | Cali Swag District ("Kickback", "Teach Me How to Dougie") |
| 191 | January 20, 2011 (2011-01-20) | Cameron Diaz, Jason Priestley, Luke Perry, Greg Fitzsimmons | N/A |
| 192 | January 21, 2011 (2011-01-21) | Bill Engvall, Johnny Weir | My Chemical Romance ("Vampire Money") |
| 193 | January 25, 2011 (2011-01-25) | Ashley Tisdale, Kevin Hart | Grace Potter and the Nocturnals ("Paris (Ooh La La)") |
| 194 | January 26, 2011 (2011-01-26) | Vanessa Williams, Shorty Rossi, Bret Ernst | N/A |
| 195 | January 27, 2011 (2011-01-27) | Jason Statham, Busy Philipps | Wiz Khalifa ("Black and Yellow") |
| 196 | January 28, 2011 (2011-01-28) | Jennifer Love Hewitt, Guy Fieri, Brian Wilson | N/A |

### February

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 197 | February 1, 2011 (2011-02-01) | Kristen Bell, Jake Johnson, | Slash ("Brown Sugar") |
| 198 | February 2, 2011 (2011-02-02) | Kourtney Kardashian, DeSean Jackson | The Thermals |
| 199 | February 3, 2011 (2011-02-03) | Mindy Kaling, Derek Fisher | Jasper Redd |
| 200 | February 4, 2011 (2011-02-04) | Billy Gardell, Rachel Bilson | OK Go |
| 201 | February 8, 2011 (2011-02-08) | Aubrey Plaza | Jamie Foxx |
| 202 | February 9, 2011 (2011-02-09) | Channing Tatum, Margaret Cho | 50 Cent, Governor |
| 203 | February 10, 2011 (2011-02-10) | Joan Rivers, Greg Jennings, Baron Vaughn | N/A |
| 204 | February 11, 2011 (2011-02-11) | Brad Womack, Taylor Momsen | The Pretty Reckless |
| 205 | February 15, 2011 (2011-02-15) | Paul Wesley, James Loney, Bobby Castillo | R. Kelly |
| "The Real Housewives of Orange County" ||||
| 206 | February 16, 2011 (2011-02-16) | Justin Bieber, Diane Kruger | Jim Jefferies |
| 207 | February 17, 2011 (2011-02-17) | Liam Neeson, Eddie Griffin | N/A |
| The Broadway Show "Rock of Ages" ||||
| 208 | February 18, 2011 (2011-02-18) | Hayden Panettiere, JWoww, Jim Jefferies | N/A |
| 209 | February 22, 2011 (2011-02-22) | Amar'e Stoudemire, Kate Gosselin, Sebastian Maniscalco | N/A |
| 210 | February 23, 2011 (2011-02-23) | Martin Lawrence, Jared Leto | Thirty Seconds to Mars |
| 211 | February 24, 2011 (2011-02-24) | Trevor Bayne, Jessica Lucas | Bobby V, Bobby Brown |
| 212 | February 25, 2011 (2011-02-25) | Anne Heche, Jason Biggs, Addi Somekh, Brian Asman | N/A |

### March

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 213 | March 1, 2011 (2011-03-01) | Owen Wilson, Aly Michalka | Terry Fator |
| 214 | March 2, 2011 (2011-03-02) | Cheryl Burke, Brandon T. Jackson | John Popper and the Duskray Troubadours ("Something Sweet") |
| 215 | March 3, 2011 (2011-03-03) | Pauly D, Michelle Rodriguez, Ron Artest | Future Funk |
| 216 | March 4, 2011 (2011-03-04) | Topher Grace, Scott Disick | Cake |
| 217 | March 8, 2011 (2011-03-08) | Forest Whitaker, Donald Glover | Steel Train |
| 218 | March 9, 2011 (2011-03-09) | Aaron Eckhart, Malin Akerman | Eric Andre |
| 219 | March 10, 2011 (2011-03-10) | Jerry O'Connell, Curtis Stone | Lupe Fiasco ("The Show Goes On") |
| 220 | March 11, 2011 (2011-03-11) | Pee-wee Herman, Emmanuelle Chriqui, Kody Brown, Meri Brown, Christine Brown, Robyn Sullivan | N/A |
| 221 | March 22, 2011 (2011-03-22) | Mike Tyson, Emmy Rossum | Jeff Ross |
| 222 | March 23, 2011 (2011-03-23) | Tori Spelling, Dean McDermott, Jim Rome | Hollywood Undead ("Hear Me Now"), Boney James |
| 223 | March 24, 2011 (2011-03-24) | Matthew McConaughey, Micky Ward | Ron Artest, Fat Joe, B-Real, Lenny Santos, Max Santos ("Go Loco") |
| 224 | March 29, 2011 (2011-03-29) | Bethenny Frankel, D. L. Hughley | Seether ("Country Song") |
| 225 | March 30, 2011 (2011-03-30) | Vanessa Hudgens, Rob Dyrdek | Sérgio Mendes ("Mas que Nada") |
| 226 | March 31, 2011 (2011-03-31) | Larry King, Romeo, Brent Weinbach | N/A |

### April

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 227 | April 1, 2011 (2011-04-01) | Brittany Snow | Snoop Dogg |
| 228 | April 5, 2011 (2011-04-05) | Rainn Wilson, Lil Jon | Panic! at the Disco |
| 229 | April 6, 2011 (2011-04-06) | Drew Carey, Sarah Shahi | Quinn Dahle |
| 230 | April 7, 2011 (2011-04-07) | Terrence Howard, Lisa Lampanelli, Joey Rodriguez | N/A |
| 231 | April 8, 2011 (2011-04-08) | Danny McBride, Camilla Luddington | Nick Carter |
| 232 | April 12, 2011 (2011-04-12) | Russell Brand, Leslie Mann | Maná |
| 233 | April 13, 2011 (2011-04-13) | Christian Slater, Damon Wayans, Jr., Omid Djalili | N/A |
| 234 | April 14, 2011 (2011-04-14) | Rosario Dawson | Prince |
| 235 | April 15, 2011 (2011-04-15) | Anne Hathaway, Anthony Anderson | Sum 41 ("Screaming Bloody Murder") |
| 236 | April 19, 2011 (2011-04-19) | Tracy Morgan, Judy Greer | REO Speedwagon |
| 237 | April 20, 2011 (2011-04-20) | Dax Shepard, Meat Loaf | Lee DeWyze |
| 238 | April 21, 2011 (2011-04-21) | Dwayne Johnson, Cat Deeley | Kimberly Clark, Zakk Wylde |
| 239 | April 22, 2011 (2011-04-22) | Tyler Perry, Maria Menounos | Lauren Pritchard |

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 240 | May 3, 2011 (2011-05-03) | Mark Ruffalo, Yvette Nicole Brown | Rex Navarrete |
| 241 | May 4, 2011 (2011-05-04) | Kaley Cuoco, Idris Elba | 2AM Club |
| 242 | May 5, 2011 (2011-05-05) | Paul Walker, Mike Rowe | Julius Sharpe |
| 243 | May 6, 2011 (2011-05-06) | Eva Mendes, Mike Epps | Carlos Santana |
| 244 | May 10, 2011 (2011-05-10) | Sinbad, Heidi Montag | Jonny Lang, Brad Whitford, Chris Layton ("All Along the Watchtower") |
| 245 | May 11, 2011 (2011-05-11) | Ice Cube, Chris Hemsworth | Earthquake |
| 246 | May 12, 2011 (2011-05-12) | Nick Cannon, Bruno Tonioli | Musiq Soulchild |
| 247 | May 13, 2011 (2011-05-13) | Enrique Iglesias, Ralph Macchio | Def Leppard |
| 248 | May 17, 2011 (2011-05-17) | Eva Longoria, Ellie Kemper | Fitz and the Tantrums |
| 249 | May 18, 2011 (2011-05-18) | Chris Colfer, Shane Mosley | Ian Edwards |
| 250 | May 19, 2011 (2011-05-19) | Will Ferrell, Niecy Nash | Sheila E and the E Family |
| 251 | May 24, 2011 (2011-05-24) | Norm Macdonald, Jerry Springer, Don Gorske | Game, Skeetox |
| 252 | May 25, 2011 (2011-05-25) | Jack Black, Elisha Cuthbert | The Script |
| 253 | May 26, 2011 (2011-05-26) | Ken Jeong, Kara DioGuardi, John Belitsky, Dan Wuebben, Mohammad Alam | N/A |
| 254 | May 27, 2011 (2011-05-27) | Randy Jackson, Russell Peters, Paul Stanley | N/A |

### June

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 255 | June 7, 2011 (2011-06-07) | David Arquette, Toni Braxton | LMFAO |
| 256 | June 8, 2011 (2011-06-08) | Mike Brown, Ice-T, Coco, Joey Chestnut | Neon Trees |
| 257 | June 9, 2011 (2011-06-09) | Don Cheadle, Terry Crews | James Adomian |
| 258 | June 10, 2011 (2011-06-10) | Conan O'Brien, Crystal Reed | Barry Manilow |
| 259 | June 14, 2011 (2011-06-14) | Adam Carolla, Mary Murphy, Hart Main | Marc Broussard |
| 260 | June 15, 2011 (2011-06-15) | Cheech Marin, Steve-O | ...And You Will Know Us by the Trail of Dead |
| 261 | June 16, 2011 (2011-06-16) | Cee Lo Green, J. J. Abrams | Brandon Scott Wolf, MC Lyte |
| 262 | June 17, 2011 (2011-06-17) | Padma Lakshmi, Lucy Punch | Deftones ("You've Seen the Butcher") |
| 263 | June 21, 2011 (2011-06-21) | J. J. Barea, Shawn Marion, Sam Trammell | Sharon Jones & The Dap-Kings |
| 264 | June 22, 2011 (2011-06-22) | Paris Hilton, Simon Pegg, June Gregg | Augustana |
| 265 | June 23, 2011 (2011-06-23) | Marc Anthony, Rocco DiSpirito | Michelle Buteau |
| 266 | June 24, 2011 (2011-06-24) | Zachary Levi, Don Mattingly | Pitbull, Ne-Yo |
| 267 | June 28, 2011 (2011-06-28) | Larry the Cable Guy, Gabrielle Anwar | Lloyd |
| 268 | June 29, 2011 (2011-06-29) | Andy Richter, Constance Marie | Eliza Doolittle |
| 269 | June 30, 2011 (2011-06-30) | Cedric the Entertainer, Jeff Lewis, Steve Mehren | N/A |

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 270 | July 1, 2011 (2011-07-01) | Patrick Dempsey, Tom Papa | David Cook |
| 271 | July 19, 2011 (2011-07-19) | Piers Morgan, Kunal Nayyar | Jordan Knight |
| 272 | July 20, 2011 (2011-07-20) | Noah Wyle, Billy Ray Cyrus | Los Lonely Boys |
| 273 | July 21, 2011 (2011-07-21) | Khloe Kardashian-Odom, Rob Kardashian, Michael Rapaport | Chris Spencer |
| 274 | July 22, 2011 (2011-07-22) | Hope Solo, Ashley Herbert | 3 Doors Down |
| 275 | July 26, 2011 (2011-07-26) | Mark-Paul Gosselaar, Amir Khan | Ringling Bros. and Barnum & Bailey Circus |
| 276 | July 27, 2011 (2011-07-27) | Tim Gunn, Jenna Elfman | Shaggy |
| Spotlight on national air-guitar winners ||||
| 277 | July 28, 2011 (2011-07-28) | Kate Walsh, The Miz | Austin Brown |
| 278 | July 29, 2011 (2011-07-29) | Chris Tucker, Matt Kemp | Jarrod Harris |

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 279 | August 2, 2011 (2011-08-02) | Jon Favreau, Aaron Paul | Colbie Caillat |
| 280 | August 3, 2011 (2011-08-03) | Kathy Griffin, Tom Felton | Lavell Crawford, 2Cellos |
| 281 | August 4, 2011 (2011-08-04) | Adrian Grenier, Affion Crockett | Matt Nathanson |
| 282 | August 5, 2011 (2011-08-05) | Hank Azaria | Nicole Scherzinger |
| 283 | August 9, 2011 (2011-08-09) | Kathryn Hahn | Joe Jonas |
| 284 | August 10, 2011 (2011-08-10) | Roseanne Barr, Michael Pena | Rival Sons |
| 285 | August 11, 2011 (2011-08-11) | Jessica Alba, David Koechner | Ellie Goulding ("Lights") |
| 286 | August 12, 2011 (2011-08-12) | Raven-Symoné | Auggie Smith |