# List of The Tonight Show Starring Jimmy Fallon episodes (2021)

This is the list of episodes for The Tonight Show Starring Jimmy Fallon in 2021.

## 2021
### January

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1379A | January 4, 2021 (2021-01-04) | Gordon Ramsay, Vanessa Kirby | Sturgill Simpson |
| Donald Trump Audio (Jimmy portrays Trump); Congressman/woman Quotes; Tonight Show News & Improved; Jimmy portrays Harry Styles in behind the scenes of "Treat People with Kindness" music video with an appearance by Phoebe Waller-Bridge (portrayed by Chloe Fineman); Sturgill Simpson performed "Life of Sin" ||||
| 1380A | January 5, 2021 (2021-01-05) | Gwen Stefani, Ralph Macchio | Gwen Stefani |
| Tariq and Jimmy talk about Mike Pence; Tonight Show Screengrabs; Tonight Show 50 Yes or No's (Gwen Stefani); The Final Word: Cobra Kai Edition (Ralph Macchio); Gwen Stefani performed "Let Me Reintroduce Myself" ||||
| 1381A | January 6, 2021 (2021-01-06) | Dan Rather, Don Cheadle, Katy Tur | Michael Kiwanuka |
| Jimmy acknowledges the 2021 storming of the United States Capitol at the top of the program before cutting to his interview with Dan Rather; Michael Kiwanuka performed "You Ain't the Problem" ||||
| 1382A | January 7, 2021 (2021-01-07) | Ricky Gervais, Daisy Edgar-Jones | The Avett Brothers |
| Tonight Show #hashtags: #WorstFirstDate; Ricky Gervais brings his new cat out during the interview; Tonight Show Wheel of Opinions (Ricky Gervais); The Avett Brothers performed "I Go to My Heart" ||||
| 1383A | January 8, 2021 (2021-01-08) | Rob Lowe, Lil Nas X, Regé-Jean Page | Mark Normand |
| Thank You Notes ||||
| 1384A | January 11, 2021 (2021-01-11) | Rashida Jones, Bill Burr | Old Dominion |
| Tonight Show Go On, Git!; Tonight Show Life Coach (Bill Burr); Old Dominion performed "Never Be Sorry" ||||
| 1385A | January 12, 2021 (2021-01-12) | Anne Hathaway, Lilly Singh | Jazmine Sullivan |
| Tariq makes fun of comedy sketch; Tonight Show Best Worst First (Anne Hathaway); Jazmine Sullivan performed "Girl Like Me" ||||
| 1386A | January 13, 2021 (2021-01-13) | Riz Ahmed, Angela Bassett | Jacob Collier featuring Mahalia |
| Tonight Show Picture This; Freestylin' with The Roots; Jacob Collier featuring Mahalia performed "All I Need" ||||
| 1387A | January 14, 2021 (2021-01-14) | Anthony Mackie, Cristin Milioti | Rico Nasty |
| Simply the Best; Tonight Show #hashtags: #DescribeATVShowBadly; Hey Robot... (Anthony Mackie); Rico Nasty performed "OHFR?" ||||
| 1388A | January 15, 2021 (2021-01-15) | Nicole Kidman, Cole Sprouse | Henry Hall |
| Jimmy and The Roots performed "Drivers License" as a sea shanty; Thank You Notes; Tonight Show 50 Yes or No's (Nicole Kidman); Henry Hall performed "Alive, Annoyed" ||||
| 1389A | January 18, 2021 (2021-01-18) | Alex Rodriguez, Spike Lee | Jimmy Jam and Terry Lewis featuring Babyface |
| Tariq's segment has been cut (Tariq and Jimmy performed "Just Once"). Note: All previous entries used this song; mistakenly put as an original song; Tonight Show Do Not Play; Tonight Show Singing Whisper Challenge (Alex Rodriguez); Jimmy Jam and Terry Lewis featuring Babyface performed "He Don't Know Nothin' Bout It" ||||
| 1390A | January 19, 2021 (2021-01-19) | Dakota Johnson, Yara Shahidi | Tate McRae |
| Tonight Show Tariq's Irk List; Dakota Settles It (Dakota Johnson); Tate McRae performed "You Broke Me First" ||||
| 1391A | January 20, 2021 (2021-01-20) | Martin Scorsese & Fran Lebowitz, Pete Buttigieg, Hunter Schafer | Playboi Carti |
| Tonight Show News & Improved; Playboi Carti performed "Slayer" ||||
| 1392A | January 21, 2021 (2021-01-21) | Shaquille O'Neal, Alison Brie | Pa Salieu |
| Normal Tweet; Tariq has buyers' remorse on a face tattoo; Lubalin performed "Turning Random Internet Drama into Songs Part 4" (appearance by Alison Brie); Tonight Show #hashtags: #MyWorstCar; Tonight Show Guess the Impression (Shaquille O'Neal); Pa Salieu performed "Frontline" ||||
| 1393A | January 22, 2021 (2021-01-22) | Rosario Dawson, Daveed Diggs | Amanda Shires featuring Jason Isbell |
| No Time to Die Title Changes; Tariq has buyers' remorse on a face tattoo; Captain Kirk Douglas debuts his own Gibson SG guitar; Tonight Show Fast Stats; Thank You Notes; Know Your Better Half (Rosario Dawson, Senator Cory Booker); Amanda Shires featuring Jason Isbell performed "The Problem" ||||
| 1394A | January 25, 2021 (2021-01-25) | Jared Leto, Jane Lynch | Jade Bird |
| Uhh... I Have Some Questions; Tariq has a problem with historically inaccurate TV series; Jimmy cleans up Steve Kornacki's office; Tonight Show Battle of the Instant Songwriters; Tonight Show 30 Seconds to... Rematch (Jared Leto); Jade Bird performed "Headstart" ||||
| 1395A | January 26, 2021 (2021-01-26) | Susan Sarandon, J. J. Watt | Thad Cockrell |
| Jimmy does Zoom interview with Vanity Fair; Tonight Show Good Name Bad Name Great Name; Tonight Show Show Me Something Good; Thad Cockrell performed "Swingin'" ||||
| 1396A | January 27, 2021 (2021-01-27) | Rami Malek, Bridget Everett | Jesus Trejo |
| Tonight Show Polls; Tonight Show Audience Suggestion Box (scene from The Bachelor revoiced with Siri, Jimmy asks the camera questions, Bridgerton theme song with lyrics, Jimmy does an advertisement, Jimmy walks through a TV portal to The Drew Barrymore Show (appearance by Drew Barrymore); Bridget Everett performed "I Can See Clearly Now" ||||
| 1397A | January 28, 2021 (2021-01-28) | Keegan-Michael Key, Terry Gross | Fontaines D.C. |
| Tonight Show News Smash; Jimmy performed a song about Joe Biden; Tonight Show #hashtags: #MyWorstInvention; Fontaines D.C. performed "A Hero's Death" ||||
| 1398A | January 29, 2021 (2021-01-29) | Justin Timberlake, London Hughes | Ozuna & Anuel AA |
| Jimmy encourages people to wear double face masks; Jimmy calls out police officers in Paris who held a party during lockdown with 90s song titles; Thank You Notes; Ozuna & Anuel AA performed "Antes" ||||

### February

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1399A | February 1, 2021 (2021-02-01) | Bryan Cranston, John Cena | Remi Wolf |
| Jimmy shows the aftermath of the nor'easter outside of the building at the top of the program; Jimmy pays tribute to Ben Affleck's love of Dunkin' Donuts; Jimmy talks about a meeting with Nike, Inc.; Fancy Soaps (Bryan Cranston); Tonight Show Think Fast! (John Cena); Remi Wolf performed "Hello Hello Hello/Photo ID" ||||
| 1400A | February 2, 2021 (2021-02-02) | Drew Barrymore, Talib Kweli | Nilüfer Yanya |
| Tonight Show Let's Get Siri–ous; Tonight Show Mad Lib Theater (Drew Barrymore); Nilüfer Yanya performed "Crash" ||||
| 1401A | February 3, 2021 (2021-02-03) | Kelly Ripa, JoJo Siwa, M. Night Shyamalan | N/A |
| Dance Battle (JoJo Siwa); Know Your Show Challenge (Kelly Ripa); debut of first footage from Old ||||
| 1402A | February 4, 2021 (2021-02-04) | Mike Myers & Dana Carvey, Camila Mendes | Olivia Rodrigo |
| Tonight Show Superlatives; Tonight Show #hashtags: #ImTheGOATOf; Tonight Show Dip Off (Tariq & Jimmy Fallon); Olivia Rodrigo performed "Drivers License" ||||
| 1403A | February 5, 2021 (2021-02-05) | Dolly Parton, Noah Centineo | slowthai featuring Skepta |
| Puppy Predictors: Super Bowl LV Edition; Tonight Show True Confessions (Dolly Parton, Noah Centineo); slowthai featuring Skepta performed "Canceled" ||||
| 1404A | February 8, 2021 (2021-02-08) | Dave Grohl, Joel Kinnaman | Foo Fighters |
| Tariq swaps out himself with a cardboard cutout for the monologue; Tonight Show News & Improved; Foo Fighters performed "Waiting on a War" ||||
| 1405A | February 9, 2021 (2021-02-09) | Priyanka Chopra-Jonas, LaKeith Stanfield, Rob Gronkowski | Joy Oladokun |
| Tonight Show One Word Songs (Priyanka Chopra-Jonas); Joy Oladokun performed "Breathe Again" ||||
| 1406A | February 10, 2021 (2021-02-10) | Dwayne Johnson, Daniel Kaluuya | Chris Stapleton |
| Tariq correctly guesses the title of Michelle Obama's new Netflix series; Greatest Moments in Zoom History; Jimmy performed an original song about Hi-C at McDonald's; Tonight Show Go On, Git!; Dwayne Johnson's mother makes an appearance during the interview; Bradley Constant participates in the Dwayne Johnson interview; Chris Stapleton performed "When I'm with You" ||||
| 1407A | February 11, 2021 (2021-02-11) | Cardi B, Alex Moffat | Lang Lang |
| Valentine's Day Cards; Tonight Show #hashtags: #AddAWordRuinALoveSong; Tonight Show Mimic Challenge (Cardi B); Lang Lang performed a medley of songs ||||
| 1408A | February 12, 2021 (2021-02-12) | Kenan Thompson, Lana Condor | Fireboy DML |
| Nicolas Cage/John Travolta Recording; The Real Bruno Mars; Jimmy performed an original song about Valentine's Day gifts; Thank You Notes; Tonight Show 5–Second Summaries (Kenan Thompson); Fireboy DML performed "Champion/Vibration" ||||
| 1409A | February 22, 2021 (2021-02-22) | Shailene Woodley, Henry Louis Gates Jr. | Kenice Mobley |
| Tonight Show Podcasts; Tonight Show Do Not Read ||||
| 1410A | February 23, 2021 (2021-02-23) | Tom Holland, Andra Day | Andra Day |
| Tonight Show Let's Get Siri–ous; Bruce Springsteen and Bob Dylan impromptu interview during the monologue (Jimmy portrays Springsteen and Dylan); Tonight Show Bad Signs; Tonight Show Instant Spoilers (Tom Holland); Andra Day performed "Strange Fruit/Tigress & Tweed" ||||
| 1411A | February 24, 2021 (2021-02-24) | Awkwafina, Ava DuVernay, Mary McCartney | Chloe x Halle |
| Jimmy portrays Joe Biden in audio of bilateral meeting; Jimmy announces non-dairy and cookie dough chunk versions of his Ben & Jerry's ice cream; Tonight Show Show Me Something Good; Chloe x Halle performed "Ungodly Hour" ||||
| 1412A | February 25, 2021 (2021-02-25) | Eddie Murphy, Eve Hewson | The Kid LAROI |
| Tariq criticizes and guesses Jimmy's monologue joke; Eddie Murphy recounts memories of people he's met; The Kid LAROI performed "Without You" ||||
| 1413A | February 26, 2021 (2021-02-26) | Queen Latifah, Paris Hilton | The Network |
| Greatest Moments in Zoom History; Thank You Notes; The Network performed "Threat Level Midnight" ||||

### March

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1414A | March 1, 2021 (2021-03-01) | John Legend, Jermaine Fowler | Arlo Parks |
| Jimmy looks back on one year of quarantine (parody of "Belle", appearance by John Legend); Tonight Show Can It Be Ballad–ed (John Legend); Arlo Parks performed "Black Dog" ||||
| 1415A | March 2, 2021 (2021-03-02) | Nick Jonas, Rita Ora | Rita Ora |
| Pickup Lines; Tonight Show News & Improved; Freestylin' with The Roots; Tonight Show Singing Whisper Challenge (Nick Jonas); Rita Ora performed "Bang Bang" ||||
| 1416A | March 3, 2021 (2021-03-03) | Leslie Jones, Elizabeth Olsen | Nicky Jam & Romeo Santos |
| Cereal Mashups; Jimmy carries on a conversation with Tariq; What Are You Doing Wednesday; FallonVision (Elizabeth Olsen, Kathryn Hahn); Nicky Jam & Romeo Santos performed "Fan de Tus Fotos" ||||
| 1417A | March 4, 2021 (2021-03-04) | Tracy Morgan, Sam Heughan | Pete Lee |
| What Members of the House Did on Their Day Off; Jimmy performed an ode to dollar stores; Tonight Show #hashtags: #RealLifePlotTwist; Tonight Show Box of Lies (Tracy Morgan) ||||
| 1418A | March 5, 2021 (2021-03-05) | Amanda Seyfried, Omar Sy | Lil Durk featuring 6lack |
| Jimmy portrays Joe Biden in footage of a meeting with the House; Tonight Show TikTok Tributes; Thank You Notes; One Word Songs (Amanda Seyfried); Lil Durk featuring 6lack performed "Still Trappin'/Stay Down" ||||
| 1419A | March 8, 2021 (2021-03-08) | Amy Poehler, Courtney B. Vance | Willie Jones |
| British royal family Phone Call; Tonight Show Film Fest; Tonight Show Do Not Play; Tonight Show Instant Spoilers (Amy Poehler); Willie Jones performed "American Dream" ||||
| 1420A | March 9, 2021 (2021-03-09) | Chrissy Teigen, Rory McIlroy | Pink Sweat$ featuring Kehlani |
| News Radio; Tonight Show Film Fest; Tonight Show Rap Remix; Jimmy tries Chrissy Teigen's products from Cravings by Chrissy Teigen; Tonight Show Best Worst First (Chrissy Teigen); Pink Sweat$ featuring Kehlani performed "At My Worst" ||||
| 1421A | March 10, 2021 (2021-03-10) | Norman Reedus, Charli & Dixie D'Amelio | Mike Vecchione |
| Jimmy portrays Joe Biden in audio of a visit to a hardware store; Tonight Show Good Name Bad Name Great Name; Tonight Show Audience Suggestion Box (Jimmy uses an app to make politicians sing, Jimmy uses a green tube to visit Don Lemon on the set of CNN Tonight with Don Lemon to celebrate Mario Day, Jimmy denies that there is a pot of gold hidden in 30 Rockefeller Plaza, Jimmy and The Roots eatbox, Norman Reedus' Guide to Motorcycle Sounds, Jimmy throws a boomerang); Know Your Sis (Charli & Dixie D'Amelio) ||||
| 1422A | March 11, 2021 (2021-03-11) | Jennifer Garner, Don Lemon | Adrianne Lenker |
| Fact Vs. Fiction; Tonight Show Film Fest; Tonight Show #hashtags: #MyFamilyIsWeird; Tonight Show Random Instrument Challenge (Jennifer Garner); Adrianne Lenker performed "Dragon Eyes" ||||
| 1423A | March 12, 2021 (2021-03-12) | Nick Offerman, Hailey Bieber | Freddie Gibbs featuring The Alchemist |
| Jimmy and Tariq have an argument; Jimmy breaks down how to spend the $1400 stimulus checks; Thank You Notes; Tonight Show Film Fest; Tonight Show True Confessions (Nick Offerman, Hailey Bieber); Freddie Gibbs featuring The Alchemist performed "Scottie Beam" ||||
| 1424A | March 15, 2021 (2021-03-15) | John Oliver, Brian Tyree Henry | Japanese Breakfast |
| Donald Trump Video; Tonight Show Drop It In; Hey Robot... (John Oliver); Japanese Breakfast performed "Be Sweet" ||||
| 1425A | March 16, 2021 (2021-03-16) | Benedict Cumberbatch, Madelaine Petsch | Rosé |
| Heinz Condiment Name Combos; Jimmy and Nick Jonas performed "Three Dots"; Tonight Show Out of Contexts; Tonight Show A to Z (Benedict Cumberbatch); Rosé performed "On the Ground" ||||
| 1426A | March 17, 2021 (2021-03-17) | Jerry Seinfeld, Taylor Kinney | Camilo |
| Tonight Show News Smash; Tonight Show #hashtags: #PartyFail; Tonight Show Life Coach with Jerry Seinfeld (Jerry Seinfeld); Camilo performed "Ropa Cara" ; Jimmy and Tariq have a Guinness pouring contest ||||
| 1427A | March 18, 2021 (2021-03-18) | Michelle Obama, Guy Raz | Edie Brickell & New Bohemians |
| Tonight Show Sorry! Wrong Zoom (Michelle Obama); Tonight Show Michelle Obama Settles It (Michelle Obama); Edie Brickell & New Bohemians performed "Stubborn Love" ||||
| 1428E | March 19, 2021 (2021-03-19) | Matthew McConaughey, Megan Rapinoe | Morris Day featuring Trinidad Jame$ |
| Jimmy broadcasts near his house; the night's broadcast is sponsored by Feeding America and State Farm; Thank You Notes; Ask the Fallons; Morris Day featuring Trinidad Jame$ performed "Headrush"; Jimmy goes back to the set and sees Steve Higgins for the first time since the COVID-19 pandemic shutdown ||||
| 1429 | March 22, 2021 (2021-03-22) | Tracee Ellis Ross, Andy Cohen | Aaron Frazer |
| Note: First broadcast back in Studio 6B since the COVID-19 lockdown; return to the set; audience for the week is made up of first responders and health care workers; Steve Higgins is back in over a year; Tonight Show News Radio; Tonight Show Go On, Git!; Tonight Show One Second Reality TV Quiz (Andy Cohen); Aaron Frazer performed "Lover Girl" ||||
| 1430 | March 23, 2021 (2021-03-23) | Chelsea Handler, Russell Brand | Mary Beth Barone |
| Tonight Show Polls; Tonight Show Why Is Your Pet Better Than Me?; Tonight Show Wheel of Opinions (Chelsea Handler); Russell Brand's dog makes an appearance during the interview; Russell Brand shows Jimmy a breathing exercise ||||
| 1431 | March 24, 2021 (2021-03-24) | Alexander Skarsgård, Karol G | Karol G |
| Tonight Show News Flub Final Four; Jimmy breaks down the cost of Disney+ Premier Access Vs. going out to a movie theater; Tonight Show #hashtags: #MyWeirdSuperstition; Alexander Skarsgård shows his drawings; Karol G performed "El Barco" ||||
| 1432 | March 25, 2021 (2021-03-25) | Maya Rudolph, Christopher Meloni | 24kGoldn |
| Tonight Show Tariq's Irk List; Tonight Show Mimic Challenge (Maya Rudolph); 24kGoldn performed "3, 2, 1" ||||
| 1433 | March 26, 2021 (2021-03-26) | Viola Davis, Addison Rae | Addison Rae |
| Tonight Show Remix; Thank You Notes; Addison Rae teaches Jimmy eight TikTok dances; Addison Rae performed "Obsessed" ||||

### April

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1434 | April 5, 2021 (2021-04-05) | Milo Ventimiglia, The Lucas Brothers | Lil Tjay featuring 6LACK |
| People Who Won't Be Winning the Mask Innovation Challenge; TikTok creators chat with Jimmy; Tonight Show Emotional Interview (Milo Ventimiglia); Lil Tjay featuring 6LACK performed "Calling My Phone" ||||
| 1435 | April 6, 2021 (2021-04-06) | Pete Davidson, Gaten Matarazzo | Glass Animals |
| Tonight Show News Radio; Tonight Show Random Instrument Challenge (Pete Davidson); Glass Animals performed "Heat Waves" ||||
| 1436 | April 7, 2021 (2021-04-07) | Denis Leary, Cristin Milioti | Rod Wave |
| Jimmy portrays Joe Biden in audio footage; Sylvester Stallone/Bob Dylan/Bruce Springsteen impromtu interview (Jimmy portrays all); Tonight Show #hashtags: #MySignatureMove; The Yahoo! Answers Lounge Singers (Jimmy Fallon & Cristin Milioti); Rod Wave performed "Tombstone" ||||
| 1437 | April 8, 2021 (2021-04-08) | Carey Mulligan, Caleb McLaughlin | Kali Uchis |
| Mike Pence Memoir Titles; Mike Pence Leaked Audiobook Recording (Jimmy portrays Pence); Tonight Show Search It & Reverse It; Tonight Show Box of Lies (Carey Mulligan); Kali Uchis performed "Telepatía" ||||
| 1438 | April 9, 2021 (2021-04-09) | Demi Lovato, Alan Kim | Demi Lovato |
| Tonight Show News Smash; Thank You Notes; Tonight Show Cake Off (Jimmy Fallon & Tariq); Tonight Show One Word Songs (Demi Lovato); Demi Lovato performed "Dancing with the Devil" ||||
| 1439 | April 12, 2021 (2021-04-12) | Snoop Dogg, H.E.R. | H.E.R. |
| Robert De Niro in Big Trailer; Tonight Show Good Name Bad Name Great Name; Tonight Show Best Friends Challenge (Snoop Dogg, Martha Stewart); H.E.R. performed "Fight for You" ||||
| 1440 | April 13, 2021 (2021-04-13) | Joseph Gordon-Levitt, Phoebe Robinson | Celeste |
| Government Compromises; Usher Phone Call; Tonight Show News & Improved; Tonight Show Show Me Something Good; Face It Challenge (Joseph Gordon-Levitt); Celeste performed "Love Is Back" ||||
| 1441 | April 14, 2021 (2021-04-14) | Allison Janney, Ṣọpẹ́ Dìrísù | Pooh Shiesty |
| Tariq is upset about the many shortages due to the pandemic; Missing Rabbit Posters; Fact Vs. Fiction; Freestylin' with The Roots; Tonight Show Dramatic Mom Texts (Allison Janney); Pooh Shiesty performed "Back in Blood" ||||
| 1442 | April 15, 2021 (2021-04-15) | Ice-T, Mike Birbiglia | Orlando Leyba |
| F9 Trailer; Tonight Show Among Us (Gaten Matarazzo, Noah Schnapp, The Roots, Victoria Tran, Sykkuno, Valkyrae & Corpse Husband); Tonight Show #hashtags: #DescribeAMovieBadly; Ice-T discusses his thoughts behind his tweets ||||
| 1443 | April 16, 2021 (2021-04-16) | Russell Wilson & Ciara, Eiza González | Jon Pardi |
| White Claw Hard Seltzer Vs. White Claw Surge; Thank You Notes; Tonight Show Jinx Challenge (Russell Wilson & Ciara); Jon Pardi performed "Tequila Little Time" ||||
| 1444 | April 19, 2021 (2021-04-19) | Michael Strahan, Tig Notaro | Emmy Blotnick |
| Everyone says what their special order is at McDonald's; Golf Pong (Michael Strahan) ||||
| 1445 | April 20, 2021 (2021-04-20) | Jane Fonda, Robin Thede, Joy Reid | Alanis Morissette |
| Jimmy addresses the conviction of Derek Chauvin in the murder of George Floyd at the top of the program; Tonight Show Best Worst First (Jane Fonda); Alanis Morissette performed "I Miss the Band" ||||
| 1446 | April 21, 2021 (2021-04-21) | Elisabeth Moss, James Cameron | Carlos Vives featuring Ricky Martin |
| New Pilot Questionnaire; Tonight Show Audience Suggestion Box (Jimmy & The Roots shows pictures of themselves from kindergarten, Let's Get Siri–ous: Oscar Edition, everyone does horse impressions, Jimmy DVRs the show, Jimmy shows an MCU recap, Mortal Prombat); Carlos Vives featuring Ricky Martin performed "Canción Bonita" ||||
| 1447 | April 22, 2021 (2021-04-22) | Kevin Bacon, Simone Biles | Ritt Momney |
| Politician Statements; Product Placement in Classic Films; Tariq's Teachable Moment; Tonight Show #hashtags: #StonerThoughts; First Drafts of Rock (Kevin Bacon); Ritt Momney performed "Put Your Records On" ||||
| 1448 | April 23, 2021 (2021-04-23) | Anna Kendrick, Wayne Federman | Masked Wolf |
| Steve Higgins wears Kiss makeup; Tonight Show Popular Mathematics; Thank You Notes; Tonight Show Sing It Like (Anna Kendrick); Masked Wolf performed "Astronaut in the Ocean" ||||
| 1449 | April 26, 2021 (2021-04-26) | Magic Johnson, Roger Daltrey | Moneybagg Yo |
| Uhh... I Have Some Questions; Jimmy Fallon, Justin Bieber & The Roots sing "Peaches" with classroom instruments; Tonight Show Do Not Play; Tonight Show First Draft Pick (Magic Johnson); Moneybagg Yo performed "Time Today/Hard for the Next" ||||
| 1450 | April 27, 2021 (2021-04-27) | Michael Che, Kate Upton | Nicki Nicole with special guest Lunay |
| United States Congress Census 2020; Tonight Show News from the Future; Tonight Show Wheel of Opinions (Michael Che); Nicki Nicole with special guest Lunay performed "Wapo Traketero/No Toque Mi Naik" ||||
| 1451 | April 28, 2021 (2021-04-28) | Luke Bryan, Brian Regan | Rupi Kaur |
| Joe Biden Presidential Address Moments (Jimmy portrays Biden); Tonight Show Screengrabs; Tonight Show Singing Whisper Challenge (Luke Bryan) ||||
| 1452 | April 29, 2021 (2021-04-29) | Michael B. Jordan, Nate Bargatze | Coi Leray |
| Crew Epilogues; Fast Stats; Tonight Show #hashtags: #WhyImSingle; Tonight Show Word Sneak (Michael B. Jordan); Coi Leray performed "No More Parties" ||||
| 1453 | April 30, 2021 (2021-04-30) | James Spader, Abbi Jacobson | Beach Bunny |
| Tonight Show Puppy Predictors: 2021 Kentucky Derby Edition; Thank You Notes; Beach Bunny performed "Cloud Nine" ||||

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1454 | May 3, 2021 (2021-05-03) | Vince Vaughn, Aidy Bryant | Girl in Red |
| Gerber Commercial; Hey, At Least I'm Not That Guy; Tonight Show Supermom Surprise; Jimmy counts down the top/bottom songs on the charts; Tonight Show 5–Second Summaries (Vince Vaughn); Girl in Red performed "Serotonin" ||||
| 1455 | May 4, 2021 (2021-05-04) | Andrew Garfield, Sara Bareilles, Renée Elise Goldsberry, Paula Pell, Busy Philipps | Thomas Rhett |
| Fact Vs. Fiction; Tonight Show Supermom Surprise; Tonight Show Rap Remix; Tonight Show One–Second Viral Video Quiz (Andrew Garfield); Thomas Rhett performed "Country Again" ||||
| 1456 | May 5, 2021 (2021-05-05) | Channing Tatum, Josh Duhamel | Joyelle Nicole Johnson |
| Jimmy, The Roots & Sara Bareilles, Renée Elise Goldsberry, Paula Pell and Busy Philipps performed "Wannabe"; Tonight Show #hashtags: #MomQuotes; Tonight Show Kid Recipes (Channing Tatum) ||||
| 1457 | May 6, 2021 (2021-05-06) | Jessica Alba, Marc Maron | Sech |
| Tonight Show News Smash; Tonight Show Supermom Surprise; What's Behind Me (Jessica Alba); Sech performed "Sal y Perrea" ||||
| 1458 | May 7, 2021 (2021-05-07) | Jessica Biel & Chiara Aurelia, Nick Thune | Mad Foxes |
| Zales Commercial; Tariq is upset about everything being pulled; Mother's Day Coupons; Tonight Show Supermom Surprise; Thank You Notes; Nick Thune tries out new comedy material; Mad Foxes performed "Crystal Glass" ||||
| 1459 | May 10, 2021 (2021-05-10) | Leslie Jones, X González | Weezer |
| Tariq's segment has been cut (Tariq and Jimmy performed "Just Once"); Tonight Show Bad Signs; Tonight Show Life Coach with Leslie Jones (Leslie Jones); Weezer performed "All the Good Ones" ||||
| 1460 | May 11, 2021 (2021-05-11) | Joel McHale, Thalía | Thalía |
| Tonight Show Polls; Tonight Show Why Is Your Pet Better Than Me?; Tonight Show A to Z (Joel McHale); Thalía performed "Mojito" ||||
| 1461 | May 12, 2021 (2021-05-12) | Dave Chappelle, Nikki Glaser | J.Period featuring Black Thought & Tiffany Gouché with narration by Dave Chappelle |
| Republican Statements; Tonight Show News Radio; Tonight Show Dave Chappelle Settles It (Dave Chappelle); J.Period featuring Black Thought & Tiffany Gouché with narration by Dave Chappelle performed "All In Your Head" ||||
| 1462 | May 13, 2021 (2021-05-13) | Keegan-Michael Key, Zoey Deutch | Conway the Machine featuring J.I.D & Ludacris |
| Joe Biden Congress Meeting (Jimmy portrays Biden); Greatest Moments in Zoom History; Tonight Show News & Improved; Tonight Show #hashtags: #AddAWordRuinATVShow; Conway the Machine featuring J.I.D & Ludacris performed "Scatterbrained" ||||
| 1463 | May 14, 2021 (2021-05-14) | Chance the Rapper, Fred Armisen | Alan Jackson |
| Mask Memories; Jimmy and Tariq lip sync "Without You"; Thank You Notes; Tonight Show Auto–Tune Up (Chance the Rapper); Alan Jackson performed "Way Down in My Whiskey" ||||
| 1464 | May 17, 2021 (2021-05-17) | Pink, Eric Bana | Natti Natasha featuring Becky G |
| Politician Spending; Tonight Show Podcasts; Tonight Show Misname That Song (Pink); Natti Natasha featuring Becky G performed "Ram Pam Pam" ||||
| 1465 | May 18, 2021 (2021-05-18) | Chris Rock, WILLOW | WILLOW featuring Travis Barker |
| Normal Vs. Not Normal; Tariq correctly guesses the sketch (Giuliani Slogans); Tonight Show True Confessions (Chris Rock, 21 Savage); WILLOW featuring Travis Barker performed "Transparent Soul" ||||
| 1466 | May 19, 2021 (2021-05-19) | Blake Shelton, Fran Lebowitz | Regard, Troye Sivan and Tate McRae |
| Inspiring Words from Your Commander in Chief; Joe Biden Factory Tour Audio (Jimmy portrays Biden); Tonight Show #hashtags: #MisheardLyrics; Tonight Show Jinx Challenge (Blake Shelton & Kelly Clarkson Vs. Jimmy Fallon & Tariq); Regard, Troye Sivan and Tate McRae performed "You" ||||
| 1467 | May 20, 2021 (2021-05-20) | Tina Fey, Wyatt Cenac | Dayglow |
| Lil John/Usher/DJ Khaled Recording; Vaccine Incentives; Tonight Show Random Instrument Challenge (Tina Fey); Dayglow performed "Close to You" ||||
| 1468 | May 21, 2021 (2021-05-21) | Constance Wu, Bowen Yang | Lord Huron featuring Allison Ponthier |
| Dating App Badges; Tariq Proves His Case/Jimmy Proves His Case; Tonight Show Picture This; Thank You Notes; Lord Huron featuring Allison Ponthier performed "I Lied" ||||
| 1469 | May 24, 2021 (2021-05-24) | Dave Grohl, Lil Nas X | Blake Shelton |
| Dave Grohl co-hosts the broadcast; Dave Grohl performed "Best of You" remixed; Tonight Show Off Songs Song Off (Dave Grohl); Commercial Jingles (Dave Grohl); Blake Shelton performed "Minimum Wage" ||||
| 1470 | May 25, 2021 (2021-05-25) | Kevin Hart, Chrissy Metz | St. Vincent |
| Tonight Show Good Name Bad Name Great Name; Freestylin' with The Roots; St. Vincent performed "Down" ||||
| 1471 | May 26, 2021 (2021-05-26) | Sofía Vergara, Jack Antonoff | Bleachers |
| Fact Vs. Fiction; Tonight Show #hashtags: #CollegeInSixWords; Tonight Show Piece of Cake Trivia (Sofía Vergara); Bleachers performed "How Dare You Want More" ||||
| 1472 | May 27, 2021 (2021-05-27) | Michael Douglas, Billy Porter | Mustafa |
| HBO Max Friends Plans; Vaccine Incentives; Tonight Show Sponsors; Tonight Show BBQ Off (appearance by Claire Saffitz); Steve Higgins and Questlove try the BBQ; Mustafa performed "What About Heaven" ||||
| 1473 | May 28, 2021 (2021-05-28) | Julianne Moore, Dave Bautista | Twenty One Pilots |
| Bad BBQ Clues and Warnings; Tonight Show Tiny Song; Tonight Show Superlatives; Thank You Notes; Tonight Show Mad Lib Theater (Julianne Moore); Twenty One Pilots performed "Shy Away" ||||

### June

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1474 | June 7, 2021 (2021-06-07) | Robert De Niro, Anthony Ramos | Anne-Marie & Niall Horan |
| Note: First full capacity audience since the COVID-19 pandemic began; Men's Warehouse Ad; Tonight Show News Radio; Tonight Show Do Not Play; Anne-Marie & Niall Horan performed "Our Song" ||||
| 1475 | June 8, 2021 (2021-06-08) | Lin-Manuel Miranda, Phoebe Dynevor | Sharon Van Etten & Angel Olsen |
| Let's Get Siri–ous; Greatest Moments in Zoom History; Lin-Manuel Miranda and Jimmy sing about the Broadway industry reopening in September, performing "Broadway's Back!" (appearances by Olga Merediz, Phylicia Rashad, Kristin Chenoweth, Christopher Jackson, Laura Benanti and Jimmy Smits); Sharon Van Etten & Angel Olsen performed "Like I Used To" ||||
| 1476 | June 9, 2021 (2021-06-09) | Kristen Bell, Dane DeHaan | Migos |
| Joe Biden Goals; Charles Rettig Statements; F9 Cannes Film Festival Trailer; Tonight Show News & Improved; Tonight Show Show Me Something Good; Tonight Show You Can Only Keep One (Kristen Bell); Migos performed "Avalanche" ||||
| 1477 | June 10, 2021 (2021-06-10) | Jason Momoa, Rose Byrne | Clairo |
| British Vs. Joe Biden Slang; Fast Stats; Tonight Show #hashtags: #AddAWordRuinASportsTeam; Water War (Jason Momoa); Clairo performed "Blouse" ||||
| 1478 | June 11, 2021 (2021-06-11) | Kathryn Hahn, Jon M. Chu | Polo G |
| Tiny Song; Tonight Show Sponsors; Thank You Notes; Tonight Show Emotional Interview (Kathryn Hahn); Polo G performed "Rap Star" ||||
| 1479 | June 14, 2021 (2021-06-14) | Ethan Hawke, Ilana Glazer | Jack Ingram, Miranda Lambert and Jon Randall |
| The Queen's Diary; Joe Biden NATO Summit Audio (Jimmy portrays Biden); Tonight Show Polls; Jimmy counts down the top/bottom songs on the charts; Tonight Show 5–Second Summaries (Ethan Hawke); Jack Ingram, Miranda Lambert and Jon Randall performed "Two-Step Down to Texas" ||||
| 1480 | June 15, 2021 (2021-06-15) | Salma Hayek, Dr. Anthony Fauci | Jessie Ware |
| Let's Get Siri–ous; YouTube Videos; Tonight Show #hashtags: #Dadvice; Tonight Show Whisper Challenge (Salma Hayek); Jessie Ware performed "Remember Where You Are" ||||
| 1481 | June 16, 2021 (2021-06-16) | Seth Meyers, Annie Murphy | Coldplay |
| Tonight Show Tariq's Irk List; Tonight Show True Confessions (Seth Meyers, Annie Murphy); Coldplay performed "Higher Power" ||||
| 1482 | June 17, 2021 (2021-06-17) | Helen Mirren, Kenya Barris | Noel Gallagher's High Flying Birds |
| Kushner's Book Titles; Travel Posters; Unpopular Father's Day Cards; Thank You Notes; Noel Gallagher's High Flying Birds performed "We're On Our Way Now" ||||
| 1483 | June 21, 2021 (2021-06-21) | Scarlett Johansson, Questlove | Graham Kay |
| Audience no longer needs to wear masks; Celebrity Quotes; Fake/Real Amazon.com Reviews; Tonight Show Why Is Your Pet Better Than Me?; Tonight Show One–Second Marvel Quiz (Scarlett Johansson) ||||
| 1484 | June 22, 2021 (2021-06-22) | Vin Diesel, Riley Keough | Modest Mouse |
| Questlove and Tariq re-enact a scene from The Bachelorette; Kristen Bell and Jimmy sing about dogs; Freestylin' with The Roots; Vin Diesel thanks fans for the success of the Fast & Furious franchise on the 20th anniversary of the release of the original film; Modest Mouse performed "We Are Between" ||||
| 1485 | June 23, 2021 (2021-06-23) | John Cena, Henry Winkler | Majid Jordan |
| Republican Body Doubles; Things You Should Avoid Saying on Tinder Hot Takes; Tonight Show Popular Mathematics; Tonight Show #hashtags: #WeddingFail; Tonight Show 30 Seconds To... (John Cena); Tonight Show Wheel of Opinions (Henry Winkler); Majid Jordan performed "Waves of Blue" ||||
| 1486 | June 24, 2021 (2021-06-24) | Jon Hamm, Ozuna | Rojo Perez |
| Joe Biden: Whisper–in–Chief; Uhh... I Have Some Questions; Fact Vs. Fiction; Jimmy plays Mario Golf: Super Rush with Collin Morikawa; Egg Russian Roulette (Jon Hamm) ||||
| 1487 | June 25, 2021 (2021-06-25) | Charlize Theron, Willie Nelson | Beabadoobee |
| The Extremely Eccentric Mini Planet; Tonight Show Superlatives; Thank You Notes; Beabadoobee performed "Last Day on Earth" ||||

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1488 | July 12, 2021 (2021-07-12) | Tom Hiddleston, Tig Notaro | GoldLink featuring Flo Milli |
| Joe Biden's Summer Reading List; Tonight Show Do Not Play; Tonight Show Mimic Challenge (Tom Hiddleston); GoldLink featuring Flo Milli performed "Raindrops" ||||
| 1489 | July 13, 2021 (2021-07-13) | BTS, Édgar Ramírez | BTS |
| Tonight Show Sponsors; Tonight Show #hashtags: #AddAWordRuinAMovie; BTS responds to rumors about themselves; BTS performed "Permission to Dance" ||||
| 1490 | July 14, 2021 (2021-07-14) | Don Cheadle, Cecily Strong | BTS |
| Sleepy World Leader of the Night: Angela Merkel Edition; Tennessee State Mottos; Greatest Moments in Zoom History; The Tonight Show Fallon Summer Reads; Something Stupid with Cecily Strong (Cecily Strong); BTS performed "Butter" ||||
| 1491 | July 15, 2021 (2021-07-15) | Mark Wahlberg, Mark Hamill | John Mayer |
| Steve Mnuchin Statements; Tariq is upset about everything being recalled; Jimmy uses his Amazon Alexa to become Shaquille O'Neal's voice (guest appearance by Shaquille O'Neal); Tonight Show News Radio; The Tonight Show Fallon Summer Reads; Tonight Show Know Your Role (Mark Hamill); John Mayer performed "Shouldn't Matter but It Does" ||||
| 1492 | July 19, 2021 (2021-07-19) | Dwayne Johnson, Joshua Jackson | Swedish House Mafia featuring Ty Dolla $ign & 070 Shake |
| Bruce Springsteen Phone Call; Tonight Show Florida News Roulette; The Tonight Show Fallon Summer Reads; Tonight Show Screengrabs; Swedish House Mafia featuring Ty Dolla $ign & 070 Shake performed "Lifetime/It Gets Better"; a clip from Late Night with Jimmy Fallon is shown featuring Jeff Goldblum and Biz Markie at the end of the broadcast as a tribute to Markie, who died the Friday before the original broadcast of the episode. ||||
| 1493 | July 20, 2021 (2021-07-20) | Jonas Brothers, Zoe Lister-Jones | Omar Apollo |
| Jimmy sees how many jokes he can tell in 30 seconds; Let's Get Siri–ous; The Tonight Show Fallon Summer Reads; Tonight Show Picture This; Tonight Show #hashtags: #DescribeASportBadly; Tonight Show Sing It Like (Jonas Brothers); Omar Apollo performed "Go Away" ||||
| 1494 | July 21, 2021 (2021-07-21) | Emilia Clarke, Mark Ronson | Brandi Carlile |
| Olympic Sport Logos with Other Meanings; Airline Slogans; Tonight Show Polls; Tonight Show Burger Off (appearance by George Motz); Around the World (Emilia Clarke); Brandi Carlile performed "Right on Time" ||||
| 1495 | July 22, 2021 (2021-07-22) | Kate Beckinsale, Fred Armisen | Leon Bridges |
| Ron Hobbs; Tokyo Olympics Fact Vs. Fiction; Jimmy criticizes the fact that a board game film adaptation is in development; Tonight Show Box of Lies (Kate Beckinsale); Kate Beckinsale and Jimmy wear beards; Fred Armisen plays guitar; Leon Bridges performed "Steam" ||||
| 1496 | July 23, 2021 (2021-07-23) | Matt Damon, Jason Sudeikis | Camila Cabello |
| Note: First show with both guests and musical performance in studio since the COVID-19 pandemic began; Jimmy and Tariq performed an original song about the Tokyo Olympics at the top of the program; Thank You Notes; Tonight Show Will It Fit? (BTS); Camila Cabello performed "Don't Go Yet" ||||

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1497 | August 9, 2021 (2021-08-09) | Billie Eilish, Abigail Breslin | Billie Eilish |
| Tonight Show Sponsors; Tonight Show Why Is Your Pet Better Than Me?; Billie Eilish performed "Happier Than Ever" ||||
| 1498 | August 10, 2021 (2021-08-10) | Barbra Streisand, Marlon Wayans | Snoh Aalegra |
| Let's Get Siri–ous; Questlove and Tariq re-enact a scene from The Bachelorette; Tonight Show News & Improved; Tonight Show Podcasts; Snoh Aalegra performed "Lost You" ||||
| 1499 | August 11, 2021 (2021-08-11) | Billy Crystal, Katie Ledecky, Jean Hanff Korelitz | Jackie Fabulous |
| Tonight Show Good Name Bad Name Great Name; Tonight Show #hashtags: #AddAWordRuinABook ||||
| 1500 | August 12, 2021 (2021-08-12) | Kit Harington, Miranda Cosgrove | Duran Duran |
| National Weather Service Heat Advisory Tips; Jimmy thanks the crew, Steve Higgins and The Roots on 1500 episodes; A Look Back at 1500 Episodes; Tonight Show News Radio; Thank You Notes; Straight Up Goes for It (Kit Harington); Duran Duran performed "Invisible" ||||
| 1501 | August 16, 2021 (2021-08-16) | Melissa McCarthy, Jai Courtney | Little Simz |
| Real Vs. Fake Vaccine Cards; Tariq is upset about things being recalled; Hey Robot... (Melissa McCarthy); Little Simz performed "Woman" ||||
| 1502 | August 17, 2021 (2021-08-17) | Michael Shannon, Paris Hilton | Courtney Barnett |
| Spirit Airlines Profit Losses; Tonight Show #hashtags: #MySummerInSixWords; Jimmy gives Michael Shannon a t-shirt; Michael Shannon tries to throw a pen into the mouth of a Hashtag the Panda plush toy; Tonight Show Slow Turn Tiny Nod (Michael Shannon); Courtney Barnett performed "Rae Street" ||||
| 1503 | August 18, 2021 (2021-08-18) | Michael Keaton, Heidi Klum | Vince Staples featuring Fousheé |
| Extra Hotel Charges; Books About Trump; Freestylin' with The Roots; Michael Keaton and Jimmy exchange signed tissues; German Word Quiz (Heidi Klum); Vince Staples featuring Fousheé performed "Take Me Home" ||||
| 1504 | August 19, 2021 (2021-08-19) | Octavia Spencer, Common | Common featuring Black Thought and Seun Kuti |
| Jimmy uses Netflix series to talk about a Netflix news story; Thank You Notes; Tonight Show Rap Remix (Common); Common featuring Black Thought and Seun Kuti performed "When We Move" ||||
| 1505 | August 23, 2021 (2021-08-23) | Kelly Clarkson, Yahya Abdul-Mateen II | Bakar |
| Tonight Show News Smash; Mike Richards' personal Jeopardy! categories; Jimmy counts down the top/bottom songs on the chart (Bottom of the Charts); Bakar performed "The Mission" ||||
| 1506 | August 24, 2021 (2021-08-24) | Andy Samberg, Madelyn Cline | Andrea Bocelli |
| Johnson & Johnson Vaccine Ad; Tonight Show Popular Mathematics; Tonight Show Misname That Song (Andy Samberg); Andrea Bocelli performed "You'll Never Walk Alone" ||||
| 1507 | August 25, 2021 (2021-08-25) | Molly Shannon, Eugenio Derbez | Chvrches |
| Greatest Moments in Zoom History; Tonight Show #hashtags: #MyTeacherIsFunny; Cry Off (Molly Shannon); Chvrches performed "Good Girls" ||||
| 1508 | August 26, 2021 (2021-08-26) | Camila Cabello, Ryan Tedder | OneRepublic |
| Ebola Farms Baked Goods Ad; Congressmen Facial Recognition; Tonight Show Polls; Thank You Notes; OneRepublic performed "Someday" ||||

### September

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1509 | September 7, 2021 (2021-09-07) | Trevor Noah, Beanie Feldstein | Gorillaz featuring AJ Tracey |
| Paramount Pictures/Statue Statements; Jeff Bezos Statements; Tonight Show Sponsors; Tonight Show Do Not Play; Tonight Show First Try (Trevor Noah); Gorillaz featuring AJ Tracey performed "Jimmy Jimmy" ||||
| 1510 | September 8, 2021 (2021-09-08) | Pete Davidson, Meredith Hagner | Baby Keem |
| Tonight Show News & Improved; Tonight Show Show Me Something Good; Tonight Show Wheel of Opinions (Pete Davidson, appearance by Jon Stewart); Baby Keem performed "Issues" ||||
| 1511 | September 9, 2021 (2021-09-09) | John Cena, J Balvin | J Balvin |
| Jimmy is stuck in the Matrix in the cold open after The Matrix Resurrections trailer dropped; Jimmy performed an original song about the NFL; Tonight Show Superlatives; Tonight Show #hashtags: #FootballRaps; Facebreakers (John Cena); J Balvin teaches Jimmy a dance; J Balvin performed "In da Getto" ||||
| 1512 | September 10, 2021 (2021-09-10) | Reese Witherspoon, Simu Liu | Lisa |
| Fact Vs. Fiction; Thank You Notes; Lisa performed "Lalisa" ||||
| 1513 | September 13, 2021 (2021-09-13) | Andrew Garfield, Patton Oswalt | Little Shop of Horrors |
| Jimmy performed an original song about New York City; Tonight Show Good Name Bad Name Great Name; Tonight Show Screengrabs; Little Shop of Horrors performed "Little Shop of Horrors/Skid Row (Downtown)" ||||
| 1514 | September 14, 2021 (2021-09-14) | Kendall Jenner, Antoni Porowski | Tina: The Tina Turner Musical |
| Fast Stats; Tonight Show #hashtags: #MyWeirdRoommate; Tonight Show Who Said It (Kendall Jenner); Jimmy brings out a cardboard cutout of Antoni Porowski; Tina: The Tina Turner Musical performed "Private Dancer" ||||
| 1515 | September 15, 2021 (2021-09-15) | Ben Platt, JoJo Siwa | Ben Platt |
| Tariq and Jimmy rap about chicken; Tariq is upset about things being recalled; Tonight Show Fast Dance Off (JoJo Siwa); Ben Platt performed "Waving Through the Window" ||||
| 1516 | September 16, 2021 (2021-09-16) | Amy Adams, Billy Crudup | Six |
| Jimmy tries to log in to his Microsoft account; Tonight Show Podcasts; Six performed "Ex-Wives" ||||
| 1517 | September 17, 2021 (2021-09-17) | Jennifer Aniston, Amandla Stenberg | Wicked |
| Tonight Show News Smash; Insurrectionist Signs; Tonight Show Superlatives; Thank You Notes; This Just In (Jennifer Aniston); Wicked performed "Popular/The Wizard and I" ||||
| 1518 | September 20, 2021 (2021-09-20) | Hasan Minhaj, James Wolk | Meek Mill |
| Pfizer–BioNTech COVID-19 vaccine Ad; Donald Trump's Mitch McConnell Replacement Recommendations; Tonight Show Polls; Freestylin' with The Roots; Tonight Show Life Coach with Hasan Minhaj (Hasan Minhaj); Meek Mill performed "Blue Notes II" with special appearance by Lil Uzi Vert ||||
| 1519 | September 21, 2021 (2021-09-21) | Nicole Kidman, Amanda Gorman | Nore Davis |
| Google Meet Ad; Tonight Show Icebreakers; Tonight Show #hashtags: #DescribeAMovieBadly; Tonight Show The Neverwed Game (Nicole Kidman) ||||
| 1520 | September 22, 2021 (2021-09-22) | Steve Martin & Martin Short, Margaret Qualley, Dr. Jane Goodall | Cynthia Erivo |
| Steve Martin, Martin Short and Jimmy catch up backstage (Tonight Show Chess, Tonight Show Guess My Temperature, Rat Trap); Password (Margaret Qualley & Jimmy Fallon Vs. Steve Martin & Martin Short); Cynthia Erivo performed "You're Not Here" ||||
| 1521 | September 23, 2021 (2021-09-23) | Michael Strahan, Colin Quinn, Justin Willman | The Killers |
| Jimmy announces the taping of the night's show around New York City at the top of the program; Mariano Rivera teaches Jimmy to pitch a baseball; Jimmy throws out the first pitch at a New York Yankees game; Jimmy goes to Madame Tussauds in New York with Michael Strahan and pranks guests before the interview; Colin Quinn and Jimmy have pizza at Joe & Pat's in Staten Island; The Roots and Jimmy visit Coney Island in Brooklyn where Justin Willman performs a magic trick; The Killers performed "Dying Breed" at the Top of the Rock ||||
| 1522 | September 24, 2021 (2021-09-24) | Andy Cohen, Alessia Cara | Alessia Cara |
| Hot Sax; Mario Voice Casting Audition Reel; Tonight Show Superlatives; Thank You Notes; Tonight Show Wheel of Musical Impressions (Alessia Cara); Tonight Show Who Said It? (Andy Cohen); Alessia Cara performed "Best Days" ||||
| 1523 | September 27, 2021 (2021-09-27) | Snoop Dogg, Chris Colfer | Mickey Guyton |
| Pfizer CEO Statement; Tonight Show Sponsors; Tonight Show Why Is Your Pet Better Than Me?; Tonight Show One–Second Songs (Snoop Dogg); Mickey Guyton performed "Lay It on Me" ||||
| 1524 | September 28, 2021 (2021-09-28) | Jake Gyllenhaal, Karamo Brown | G-Eazy featuring Demi Lovato |
| Jimmy, Questlove and Steve Higgins tell each other what they are watching; Tonight Show Bad Signs; G-Eazy featuring Demi Lovato performed "Breakdown" ||||
| 1525 | September 29, 2021 (2021-09-29) | Maluma, Michael Gandolfini | GIVĒON |
| Congressmen/Senator Job Applications; The Bachelor Potential Host Questions; Tariq loves coffee; Tonight Show Popular Mathematics; Tonight Show #hashtags: #MakeASongAboutFall; Tonight Show One Word Songs (Maluma); GIVĒON performed "For Tonight" ||||
| 1526 | September 30, 2021 (2021-09-30) | Jeff Daniels, Chloe Fineman | The Flaming Lips |
| Congressmen Statements; Brady's Fashion Lines; Tonight Show Pizza Off (appearance by Scott Wiener); Tonight Show Interview of Impressions (Chloe Fineman); The Flaming Lips performed "Mother I've Taken LSD" ||||

### October

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1527 | October 1, 2021 (2021-10-01) | Jerry Seinfeld, Léa Seydoux | TWICE |
| New England Patriots Fan Signs; Tonight Show Superlatives; Thank You Notes; Lego Seinfeld (Jerry Seinfeld); TWICE performed "The Feels" ||||
| 1528 | October 4, 2021 (2021-10-04) | Seth Meyers, Cobie Smulders | Farruko |
| The Roots have purchased the Folgers Coffee jingle and have buyers' remorse; Squid Game Spin-Off; Jimmy counts down the top/bottom songs on the chart (Bottom of the Charts); Catchphrase (Seth Meyers & Cobie Smulders Vs. Jimmy Fallon & Tariq); Farruko performed "Pepas" ||||
| 1529 | October 5, 2021 (2021-10-05) | Queen Latifah, Kaitlyn Dever | Chris Stapleton |
| Facebook Statement; Tonight Show Do Not Play; Tonight Show Best Friends Challenge (Queen Latifah); Chris Stapleton performed "You Should Probably Leave" ||||
| 1530 | October 6, 2021 (2021-10-06) | Anthony Anderson, The Cast of Squid Game | Charli XCX |
| Squid Game Subtitles; Bill de Blasio Mayoral Slogans; Tariq is tired of the news (News Alert); Tonight Show #hashtags: #MyCrazyInvention; Tonight Show Schoolyard Games (The Cast of Squid Game); Charli XCX performed "Good Ones" ||||
| 1531 | October 7, 2021 (2021-10-07) | Madonna, The Kids Tonight Show hosts | Reba McEntire |
| Tonight Show News Smash; Hot Goss!; Tonight Show Kid Theater (Madonna); Reba McEntire performed "Take It Back/Why Haven't I Heard from You" ||||
| 1532 | October 8, 2021 (2021-10-08) | Jason Momoa, Ana de Armas | Big Red Machine |
| Tonight Show Superlatives; Thank You Notes; Tonight Show Box of Lies (Ana de Armas); Jimmy dresses up as Jason Momoa; Big Red Machine performed "The Ghost of Cincinnati" ||||
| 1533 | October 11, 2021 (2021-10-11) | Chelsea Handler, Finn Wolfhard | James Blake featuring Slowthai |
| Tonight Show Picture This; Tonight Show True Confessions (Chelsea Handler, Finn Wolfhard); James Blake featuring Slowthai performed "Funeral" ||||
| 1534 | October 12, 2021 (2021-10-12) | Daniel Craig, Meghan Trainor | Chlöe |
| Tonight Show You Pick the Joke; Jimmy and Chris Stapleton performed an original song about Nancy Meyers films; Daniel Craig reminisces about his fifteen years starring in the James Bond franchise and shares a martini with Jimmy; Chlöe performed "Have Mercy" ||||
| 1535 | October 13, 2021 (2021-10-13) | Matt Damon, Ben Affleck & Nicole Holofcener, Victoria Beckham | Holly Humberstone |
| Uhh... I Have Some Questions; Tonight Show Can You Feel It? (Victoria Beckham); Holly Humberstone performed "Scarlett" ||||
| 1536 | October 14, 2021 (2021-10-14) | Jamie Foxx, Phoebe Robinson, William Shatner | Tom Thakkar |
| Adele 30 Album Tracklist; The Complete Take Two (Jamie Foxx) ||||
| 1537 | October 15, 2021 (2021-10-15) | Oscar Isaac, Jo Firestone | Alec Benjamin |
| The crew and Oscar Isaac listen to Adele; Tonight Show Superlatives; Thank You Notes; Oscar Isaac plays guitar; Alec Benjamin performed "Older" ||||
| 1538 | October 26, 2021 (2021-10-26) | Drew Barrymore, Mo Rocca | Måneskin |
| Tonight Show Sponsors; What's Behind Me? (Drew Barrymore); Måneskin performed "Beggin'" ||||
| 1539 | October 27, 2021 (2021-10-27) | Elton John, Ava DuVernay | Walker Hayes |
| New Netflix Series; Tariq is upset about things being recalled; Tonight Show News Radio; Walker Hayes performed "Fancy Like" ||||
| 1540 | October 28, 2021 (2021-10-28) | Chrissy Teigen, Matthias Schweighöfer | Skepta |
| Facebook Ad; Tonight Show #hashtags: #MakeAMovieSoundScary; Tonight Show Rap Remix; Chrissy Teigen and Jimmy have a dish from her new cookbook; Tonight Show Pup Quiz (Chrissy Teigen); Matthias Schweighöfer teaches Jimmy how to dance; Skepta performed "Lit Like This" ||||
| 1541 | October 29, 2021 (2021-10-29) | Idris Elba, Keri Russell | Sabrina Carpenter |
| Candy Warning Labels; Joe Biden/Pope Francis Inner Thoughts; Tonight Show Superlatives; Thank You Notes; Tonight Show The Fastest Card in the West (Idris Elba); Sabrina Carpenter performed "Skinny Dipping" ||||

### November

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1542 | November 2, 2021 (2021-11-02) | Kumail Nanjiani, Fred Armisen | Lucy Dacus |
| Tonight Show Polls; Pictionary (Tariq & Fred Armisen Vs. Kumail Nanjiani & Jimmy Fallon); Fred Armisen plays guitar; Lucy Dacus performed "VBS" ||||
| 1543 | November 3, 2021 (2021-11-03) | Kristen Stewart, Bad Bunny | Joyelle Nicole Johnson |
| Jimmy, Tariq and Steve Higgins' Inner Thoughts; Freestylin' with The Roots ||||
| 1544 | November 4, 2021 (2021-11-04) | Ariana Grande, Adrien Brody | Blxst featuring Ty Dolla $ign |
| Aaron Rodgers Statements; CVS Pharmacy Doctor Application Questions; Dunkin' Donuts Ad; Tonight Show Good Name Bad Name Great Name; Tonight Show #hashtags: #MyDreamApp; Adrien Brody does a magic trick; Blxst featuring Ty Dolla $ign performed "Chosen" ||||
| 1545 | November 5, 2021 (2021-11-05) | Kieran Culkin, D.J. "Shangela" Pierce | Camilo with Evaluna |
| Tonight Show Superlatives; Thank You Notes; Tonight Show Who Said It? (Kieran Culkin); Camilo with Evaluna performed "Índigo" ||||
| 1546 | November 8, 2021 (2021-11-08) | Michael Che, Ed Sheeran, Martha Stewart | Summer Walker |
| Vin Diesel Voicemail; Tonight Show News & Improved; Charades (Martha Stewart & Jimmy Fallon Vs. Michael Che & Ed Sheeran); Summer Walker performed "Unloyal" ||||
| 1547 | November 9, 2021 (2021-11-09) | Will Smith, Jack Whitehall | Nathaniel Rateliff & The Night Sweats |
| Tonight Show #hashtags: #TheyNeedToFix; Tonight Show Name That Song Challenge (Will Smith); Nathaniel Rateliff & The Night Sweats performed "Survivor" ||||
| 1548 | November 10, 2021 (2021-11-10) | Ryan Reynolds, Lucy Hale, Beeple | Sam Fender |
| Tonight Show News Smash; Tonight Show Sponsors; Note: Ryan Reynolds makes a surprise appearance in place of Will Ferrell, who canceled; Tonight Show You Have to Stop (Ryan Reynolds); Sam Fender performed "Spit of You" ||||
| 1549 | November 11, 2021 (2021-11-11) | Taylor Swift, Colin Quinn | Jared Freid |
| Studio audience is made up of servicemen/women; Tiny Song; Box of Lies (Taylor Swift); Chris Rock makes a surprise appearance during Colin Quinn's interview ||||
| 1550 | November 12, 2021 (2021-11-12) | Taraji P. Henson, Steve Zahn | Damon Albarn |
| DJ Khaled/Lil John/Jason Derulo Phone Call; Tonight Show Superlatives; Thank You Notes; Tonight Show Sing It Like (Taraji P. Henson); Damon Albarn performed "Darkness to Light" ||||
| 1551 | November 15, 2021 (2021-11-15) | Bill Murray, Dan Aykroyd & Ernie Hudson, FINNEAS | FINNEAS |
| Tonight Show Pros and Cons; FINNEAS performed "Only a Lifetime" ||||
| 1552 | November 16, 2021 (2021-11-16) | Jared Leto, Vanessa Hudgens | Tom Morello featuring grandson |
| Democrat Statements; Tonight Show Why Is Your Pet Better Than Me?; Jimmy helps Jared Leto come up with an album title; Tom Morello featuring grandson performed "Hold the Line" ||||
| 1553 | November 17, 2021 (2021-11-17) | Lin-Manuel Miranda, Roman Reigns | Big Boi featuring Sleepy Brown |
| Papa John's Pizza Commercial; Tonight Show #hashtags: #IfIHadATrillionDollars; Tonight Show Wheel of Freestyle (Lin-Manuel Miranda); Big Boi featuring Sleepy Brown performed "Animals" ||||
| 1554 | November 18, 2021 (2021-11-18) | Simu Liu, Ruth Negga | Big Sean featuring Hit-Boy |
| TJ Maxx Ad; Tariq is upset about things being recalled; Beat Saber (Simu Liu); Simu Liu shows Jimmy a dance move; Big Sean featuring Hit-Boy performed "What a Life" ||||
| 1555 | November 19, 2021 (2021-11-19) | Whoopi Goldberg, Karol G | Dry Cleaning |
| The Real Turkeys of Gobblers Rest; Tonight Show Superlatives; Thank You Notes; Whoopi Goldberg brings Jimmy baked goods; Dry Cleaning performed "Scratchcard Lanyard" ||||
| 1556 | November 22, 2021 (2021-11-22) | Jeremy Renner, Kristin Chenoweth | Ali Kolbert |
| Joe Biden Birthday Texts; Knockoff Toys; Tonight Show Picture This; Tonight Show Battle of the Instant Songwriters ||||
| 1557 | November 23, 2021 (2021-11-23) | Hailee Steinfeld, Liza Koshy | Avril Lavigne with Travis Barker |
| Tonight Show #hashtags: #MyFamilyIsWeird; Tonight Show Do Not Read; Tonight Show Singing Whisper Challenge (Hailee Steinfeld); Avril Lavigne with Travis Barker performed "Bite Me" ||||
| 1558 | November 24, 2021 (2021-11-24) | Julie Bowen, Keke Palmer | Zoe Wees |
| Bar Signs; Tiny Song; Bush Gardens Ad; Tonight Show Pros and Cons; Tonight Show Audience Suggestion Box (sports footage with tennis grunting, the world's largest hand turkey, the crew explains what they would do if they scored a touchdown); Julie Bowen and Jimmy recreate Hallmark Channel Christmas film posters; Keke Palmer does impressions; Zoe Wees performed "That's How It Goes" ||||
| 1559 | November 25, 2021 (2021-11-25) | Will Ferrell & Paul Rudd, Sebastian Maniscalco | Jenny Lewis |
| What to Expect at the Airport; Tonight Show Superlatives; Thank You Notes; Tiny Dancer (Will Ferrell & Paul Rudd); Jenny Lewis performed "Puppy and a Truck" ||||
| 1560 | November 29, 2021 (2021-11-29) | Michael Strahan, Alessia Cara | Pistol Annies |
| Fact Vs. Fiction; Tonight Show Musical Genre Challenge (Alessia Cara); Michael Strahan and Jimmy give a pep talk; Michael Strahan reads an unused monologue joke; Pistol Annies performed "Hell of a Holiday" ||||
| 1561 | November 30, 2021 (2021-11-30) | Maya Rudolph, Nicholas Braun, Rita Moreno | Dusty Slay |
| Tonight Show Misname That Song (Maya Rudolph); Rita Moreno shows Jimmy how to perfect a dance move at the climax of "America" in West Side Story ||||

### December

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1562 | December 1, 2021 (2021-12-01) | Seth Rogen, Machine Gun Kelly | Macklemore featuring Windser |
| Mehmet Oz Senate Campaign Slogans; the crew shares the most-played songs on their Spotify playlists; Tonight Show #hashtags: #TravelFail; Tonight Show Auto–Tune Up (Machine Gun Kelly); Macklemore featuring Windser performed "Next Year" ||||
| 1563 | December 2, 2021 (2021-12-02) | Blake Shelton, Ana Gasteyer & Rachel Dratch | Blake Shelton |
| Donald Trump Book Titles; Tonight Show 12 Days of Christmas Sweaters; Tonight Show Off Songs Song Off (Blake Shelton); Blake Shelton performed "Come Back as a Country Boy" ||||
| 1564 | December 3, 2021 (2021-12-03) | Tyler Perry, Michael Bublé | CKay |
| Steve Higgins and Jimmy tell each other what holiday candles they are going to purchase; Tonight Show Superlatives; Thank You Notes; Tonight Show 12 Days of Christmas Sweaters; Password (Tyler Perry & Jimmy Fallon Vs. Questlove & Michael Bublé); CKay performed "Love Nwantiti/Emiliana" ||||
| 1565 | December 6, 2021 (2021-12-06) | Jonah Hill, Tig Notaro | Dan + Shay |
| Jimmy debuts a new single with Ariana Grande and Megan Thee Stallion ("It Was a Masked Christmas"); Tonight Show 12 Days of Christmas Sweaters; Dan + Shay performed "Officially Christmas" ||||
| 1566 | December 7, 2021 (2021-12-07) | Chloë Grace Moretz, Nick Thune | Wizkid featuring Tems |
| European Leader Advice for Joe Biden; Nicolas Cage/John Travolta Phone Call; Tig Notaro makes a surprise appearance after the monologue; Tonight Show 12 Days of Christmas Sweaters; Tonight Show Show Me Something Good; Chloë Grace Moretz impersonates Britney Spears; Wizkid featuring Tems performed "Essence" ||||
| 1567 | December 8, 2021 (2021-12-08) | Nicole Kidman, Úrsula Corberó | Stromae |
| Person/Statue Statements; Tonight Show 12 Days of Christmas Sweaters; Tonight Show Can You Feel It? (Nicole Kidman); Jimmy asks Nicole Kidman holiday-related questions; Stromae performed "Santé" ||||
| 1568 | December 9, 2021 (2021-12-09) | Miley Cyrus & Pete Davidson, Yahya Abdul-Mateen II | Miley Cyrus |
| Tonight Show 12 Days of Christmas Sweaters; Tonight Show True Confessions (Miley Cyrus & Pete Davidson); Yahya Abdul-Mateen II and Jimmy make portraits of each other; Miley Cyrus performed "It Should Have Been Me" ||||
| 1569 | December 10, 2021 (2021-12-10) | President Joe Biden, Jodie Turner-Smith | Rick Ross featuring Jazmine Sullivan |
| Tiny Song; Tonight Show 12 Days of Christmas Sweaters; Thank You Notes; Tonight Show Superlatives; Jimmy gives Jodie Turner-Smith a gift basket; Rick Ross featuring Jazmine Sullivan performed "Outlawz" ||||
| 1570 | December 13, 2021 (2021-12-13) | Dakota Johnson, Bobby Cannavale | Kelly Clarkson |
| Mike Pence Campaign Slogans; Tonight Show 12 Days of Christmas Sweaters; Jimmy quizzes Dakota Johnson on Home Alone; Tonight Show 5–Second Summaries (Dakota Johnson); Kelly Clarkson performed "Blessed" ||||
| 1571 | December 14, 2021 (2021-12-14) | Matthew McConaughey, Alana Haim | Niko Moon |
| Tonight Show 12 Days of Christmas Sweaters; Matthew McConaughey and Jimmy performed an original Christmas song ("This Christmas Will Be Different") and "Christmas (Baby Please Come Home)" with special appearance by Haim; Niko Moon performed "No Sad Songs" ||||
| 1572 | December 15, 2021 (2021-12-15) | Penélope Cruz, Kid Cudi, Joanna Stern | N/A |
| Tonight Show #hashtags: #AddAWordRuinAChristmasSong; Tonight Show 12 Days of Christmas Sweaters; Head Swap ||||
| 1573 | December 16, 2021 (2021-12-16) | Scarlett Johansson, Bowen Yang | Toni Cornell |
| Tonight Show Drop It In; Tonight Show 12 Days of Christmas Sweaters; Tonight Show Do Not Play; Tonight Show Mimic Challenge (Scarlett Johansson); Toni Cornell performed "Nothing Compares 2 U" ||||
| 1574 | December 17, 2021 (2021-12-17) | Reese Witherspoon, Mike Birbiglia | Robert Plant featuring Alison Krauss |
| Jimmy is torn on what toys to purchase for the holidays; Tonight Show 12 Days of Christmas Sweaters (the Radio City Rockettes do a surprise performance); Thank You Notes; Mike Birbiglia does jokes from his podcast; Robert Plant featuring Alison Krauss performed "Searching for My Love" ||||