# 2022 Karlsruhe Open – Singles

Mayar Sherif was the defending champion and successfully defended her title, defeating Bernarda Pera in the final, 6–2, 6–4.

## Seeds

* Alison Van Uytvanck (second round)
* Mayar Sherif (champion)
* Anna Bondár (semifinals)
* Greet Minnen (second round, withdrew)
* Panna Udvardy (quarterfinals)
* Clara Burel (first round)
* Dalma Gálfi (quarterfinals)
* Bernarda Pera (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Anna-Lena Friedsam | 5 | 0$^r$ | | | | |
| 8 | Bernarda Pera | 7 | 2 | | | | |
| 8 | Bernarda Pera | 7 | 2 | 8 | Bernarda Pera | 2 | 4 |
| | | | | 2 | Mayar Sherif | 6 | 6 |
| 3 | Anna Bondár | 2 | 2 | 2 | Mayar Sherif | 6 | 6 |
| 2 | Mayar Sherif | 6 | 6 | | | | |

### Top half

| First Round | First Round | First Round | First Round | First Round | Second Round | Second Round | Second Round | Second Round | Second Round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | A Van Uytvanck | 6 | 6 | | | | | | | | | | | | | | |
| | T Korpatsch | 4 | 1 | | 1 | A Van Uytvanck | 6$^2$ | 7$^7$ | 3 | | | | | | | | |
| WC | E Seidel | 1 | 3 | | | A-L Friedsam | 7$^7$ | 6$^5$ | 6 | | | | | | | | |
| | A-L Friedsam | 6 | 6 | | | | | | | | A-L Friedsam | 6 | 7$^7$ | | | | |
| | S Vögele | 6$^6$ | 3 | | | | | | | 7 | D Gálfi | 3 | 6$^1$ | | | | |
| | L Zhu | 7$^8$ | 6 | | | L Zhu | 7$^7$ | 5 | 1 | | | | | | | | |
| | A Krunić | 6 | 5 | 1 | 7 | D Gálfi | 6$^5$ | 7 | 6 | | | | | | | | |
| 7 | D Gálfi | 3 | 7 | 6 | | | | | | | | | | | A-L Friedsam | 5 | 0$^r$ |
| 4 | G Minnen | 6 | 6 | | | | | | | | | | | 8 | B Pera | 7 | 2 |
| PR | B Schoofs | 1 | 4 | | 4 | G Minnen | | | | | | | | | | | |
| | M Hontama | 6 | 6 | | | M Hontama | w/o | | | | | | | | | | |
| WC | M Timofeeva | 4 | 1 | | | | | | | | M Hontama | 5 | 5 | | | | |
| Alt | M Minella | 4 | 3 | | | | | | | 8 | B Pera | 7 | 7 | | | | |
| | J Niemeier | 6 | 6 | | | J Niemeier | 6 | 4 | 6$^3$ | | | | | | | | |
| | N Schunk | 6 | 4 | 1 | 8 | B Pera | 3 | 6 | 7$^7$ | | | | | | | | |
| 8 | B Pera | 4 | 6 | 6 | | | | | | | | | | | | | |

### Bottom half

| First Round | First Round | First Round | First Round | First Round | Second Round | Second Round | Second Round | Second Round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | C Burel | 6 | 2 | 6$^6$ | | | | | | | | | | | | |
| PR | P Hon | 3 | 6 | 7$^8$ | PR | P Hon | 1 | 1 | | | | | | | | |
| | E Gorgodze | 6 | 1 | 1 | WC | E Lys | 6 | 6 | | | | | | | | |
| WC | E Lys | 2 | 6 | 6 | | | | | WC | E Lys | 0 | 5 | | | | |
| | V Tomova | 3 | 3 | | | | | | 3 | A Bondár | 6 | 7 | | | | |
| | R Marino | 6 | 6 | | | R Marino | 3 | 2 | | | | | | | | |
| | H Tan | 4 | 2 | | 3 | A Bondár | 6 | 6 | | | | | | | | |
| 3 | A Bondár | 6 | 6 | | | | | | | | | | 3 | A Bondár | 2 | 2 |
| 5 | P Udvardy | 6 | 6 | | | | | | | | | | 2 | M Sherif | 6 | 6 |
| WC | L Siegemund | 3 | 2 | | 5 | P Udvardy | 6 | 6 | | | | | | | | |
| | T Maria | 6 | 4 | 2 | | M Buzărnescu | 1 | 0 | | | | | | | | |
| | M Buzărnescu | 1 | 6 | 6 | | | | | 5 | P Udvardy | 4 | 6$^5$ | | | | |
| | L Pigossi | 6 | 1 | | | | | | 2 | M Sherif | 6 | 7$^7$ | | | | |
| | P Hercog | 4 | 0$^r$ | | | L Pigossi | 2 | 2 | | | | | | | | |
| | K Baindl | 2 | 3 | | 2 | M Sherif | 6 | 6 | | | | | | | | |
| 2 | M Sherif | 6 | 6 | | | | | | | | | | | | | |