# 2022 República Dominicana Open – Singles

Juan Pablo Varillas was the defending champion but lost in the first round to Thiago Agustín Tirante.
Pedro Cachin won the title after defeating Marco Trungelliti 6–4, 2–6, 6–3 in the final.

## Seeds

* Roberto Carballés Baena (quarterfinals)
* Pedro Cachin (champion)
* Tomás Martín Etcheverry (semifinals)
* Daniel Elahi Galán (semifinals)
* Juan Pablo Varillas (first round)
* Camilo Ugo Carabelli (second round)
* Federico Delbonis (second round)
* Facundo Mena (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| | Marco Trungelliti | 7 | 6 | | | | | | |
| 4 | Daniel Elahi Galán | 5 | 3 | | | | | | |
| 4 | Daniel Elahi Galán | 5 | 3 | | | Marco Trungelliti | 4 | 6 | 3 |
| | | | | | 2 | Pedro Cachin | 6 | 2 | 6 |
| 3 | Tomás Martín Etcheverry | 6 | 6$^5$ | 4 | 2 | Pedro Cachin | 6 | 2 | 6 |
| 2 | Pedro Cachin | 4 | 7$^7$ | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | R Carballés Baena | 6 | 7 | | | | | | | | | | | | | | |
| Alt | G Villanueva | 0 | 5 | | 1 | R Carballés Baena | 6 | 4 | | | | | | | | | |
| | D Džumhur | 6 | 7 | | | D Džumhur | 4 | 0$^r$ | | | | | | | | | |
| WC | P Bertran | 4 | 5 | | | | | | | 1 | R Carballés Baena | 2 | 5 | | | | |
| | F Comesaña | 1 | 2 | | | | | | | | M Trungelliti | 6 | 7 | | | | |
| | M Trungelliti | 6 | 6 | | | M Trungelliti | 6 | 6 | | | | | | | | | |
| | D Dutra da Silva | 6 | 1 | 3 | 7 | F Delbonis | 2 | 3 | | | | | | | | | |
| 7 | F Delbonis | 3 | 6 | 6 | | | | | | | | | | | M Trungelliti | 7 | 6 |
| 4 | DE Galán | 6 | 6 | | | | | | | | | | | 4 | DE Galán | 5 | 3 |
| Q | Facundo Juárez | 3 | 2 | | 4 | DE Galán | 2 | 6 | 7$^{13}$ | | | | | | | | |
| | C-M Stebe | 6 | 2 | 6 | | C-M Stebe | 6 | 4 | 6$^{11}$ | | | | | | | | |
| | GA Olivieri | 3 | 6 | 2 | | | | | | 4 | DE Galán | 6 | 7$^7$ | | | | |
| WC | N Hardt | 6 | 6 | | | | | | | | TA Tirante | 3 | 6$^4$ | | | | |
| Alt | G Lama | 2 | 2 | | WC | N Hardt | 2 | 4 | | | | | | | | | |
| | TA Tirante | 3 | 6 | 7 | | TA Tirante | 6 | 6 | | | | | | | | | |
| 5 | JP Varillas | 6 | 4 | 5 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | C Ugo Carabelli | 6 | 6 | | | | | | | | | | | | | | |
| | R Bonadio | 2 | 3 | | 6 | C Ugo Carabelli | 3 | 4 | | | | | | | | | |
| | R Olivo | 6 | 4 | 7 | | R Olivo | 6 | 6 | | | | | | | | | |
| WC | G Bueno | 2 | 6 | 5 | | | | | | R Olivo | 4 | 3 | | | | | |
| Q | RA Burruchaga | 6 | 2 | 6 | | | | | 3 | TM Etcheverry | 6 | 6 | | | | | |
| Q | N Mejía | 2 | 6 | 4 | Q | RA Burruchaga | 4 | 3 | | | | | | | | | |
| Q | P Boscardin Dias | 0$^r$ | | | 3 | TM Etcheverry | 6 | 6 | | | | | | | | | |
| 3 | TM Etcheverry | 0 | | | | | | | | | | | 3 | TM Etcheverry | 6 | 6$^5$ | 4 |
| 8 | F Mena | 7$^8$ | 4 | | | | | | | | | | 2 | P Cachin | 4 | 7$^7$ | 6 |
| Q | P Kypson | 6$^6$ | 1$^r$ | | 8 | F Mena | 6 | 6 | | | | | | | | | |
| LL | N Álvarez | 7 | 4 | 6 | LL | N Álvarez | 4 | 2 | | | | | | | | | |
| Q | N Barrientos | 5 | 6 | 3 | | | | | 8 | F Mena | 3 | 2 | | | | | |
| | A Giannessi | 1 | 5 | | | | | | 2 | P Cachin | 6 | 6 | | | | | |
| Alt | R Quiroz | 6 | 1$^r$ | | | A Giannessi | 1 | 2 | | | | | | | | | |
| | G Melzer | 4 | 1 | | 2 | P Cachin | 6 | 6 | | | | | | | | | |
| 2 | P Cachin | 6 | 6 | | | | | | | | | | | | | | |