# Jen Sheen

Jen Sheen (Chinese: 沈正韻; born February 20, 1957) is a Taiwanese-American geneticist and molecular biologist at Massachusetts General Hospital and Harvard Medical School who is known for her work on plant signaling networks. She is an elected member of the American Association for the Advancement of Science.

## Education and career

Sheen's interest in plants followed her childhood on a sugarcane plantation in rural Taiwan. She has a B.S. from National Taiwan University (1980) and earned a Ph.D. in 1986 from Harvard University where she worked with Lawrence Bogorad. Following her Ph.D., she received endowment funds that enabled her to start her own lab at Harvard Medical School in 1987 with flexibility that enabled her to define her own research path. She was promoted to professor of genetics in 2005. Concurrently she has held positions in molecular biology at Massachusetts General Hospital.

## Research

Sheen is known for her research using plants as model systems to study cell signaling. While a graduate student at Harvard University, she worked on the genetic system of maize with the goal of increasing crop yields. When starting her own lab, she established a model system using plant protoplasts, cells which can be maintained easily in laboratory containers. She then shifted her work to studying protoplasts in Arabidopsis, a plant commonly used as a model system, and Sheen has developed the use of green fluorescent protein in higher plant research. Sheen has used the plant protoplast model system to examine innate immunity, taking advantage of the plant system's ability to provide answers about innate immunity more rapidly than other systems in use. Sheen's research includes investigations into signaling pathways in plants, and has determined how plants sense sugars, and how stressors such as hydrogen peroxide are sensed by plants.

## Selected publications

* Asai, Tsuneaki; Tena, Guillaume; Plotnikova, Joulia; Willmann, Matthew R.; Chiu, Wan-Ling; Gomez-Gomez, Lourdes; Boller, Thomas; Ausubel, Frederick M.; Sheen, Jen (February 2002). "MAP kinase signalling cascade in Arabidopsis innate immunity". Nature. 415 (6875): 977–983. Bibcode:2002Natur.415..977A. doi:10.1038/415977a. ISSN 1476-4687. PMID 11875555. S2CID 4419225.
* Yoo, Sang-Dong; Cho, Young-Hee; Sheen, Jen (July 2007). "Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis". Nature Protocols. 2 (7): 1565–1572. doi:10.1038/nprot.2007.199. ISSN 1750-2799. PMID 17585298. S2CID 8852255.
* Kovtun, Yelena; Chiu, Wan-Ling; Tena, Guillaume; Sheen, Jen (14 March 2000). "Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants". Proceedings of the National Academy of Sciences. 97 (6): 2940–2945. doi:10.1073/pnas.97.6.2940. ISSN 0027-8424. PMC 16034. PMID 10717008.

## Awards and honors

Sheen was elected a fellow of the American Association for the Advancement of Science in 2009. In 2013, she received the Martin Gibbs Medal from the American Society of Plant Biologists who acknowledge Sheen for "her seminal and innovative contributions to the understanding of molecular mechanisms underlying the plant signal transduction cascades that mediate nutrient, hormone, and environmental stress responses and pathogen defenses in plants".