# Sinister Six

The Sinister Six are a group of supervillains in American comic books published by Marvel Comics, mainly those featuring Spider-Man. The members are drawn from the character's list of enemies, with the original members forming the team in The Amazing Spider-Man Annual #1 (October 1964). Led by Doctor Octopus (introduced in issue #3), the team in its premiere followed swiftly the very early appearances of many of the most enduring members of Spider-Man's rogues gallery: the Vulture (issue #2), the Sandman (issue #4), Electro (issue #9), Mysterio (issue #13), and Kraven the Hunter (issue #15). While Doctor Octopus has generally remained its leader, the Sinister Six has had multiple variations of composition.
The team has been adapted into various forms of media, mainly in animated series and video games.

## Publication history

The Sinister Six first appeared in The Amazing Spider-Man Annual #1 (January 1964).

## Fictional team biography
### Original Sinister Six

After suffering two defeats from Spider-Man, Doctor Octopus is separated from his tentacle pack. After his tentacle pack breaks free and helps Doctor Octopus get out of prison, he contacts every known supervillain who had crossed paths with Spider-Man. Only Electro, Kraven the Hunter, the original Mysterio, the Sandman, and the original Vulture respond. As none of the members are willing to relinquish the honor of killing Spider-Man themselves, they decide to challenge Spider-Man individually with the order in which they face him determined by a random drawing. The Sinister Six kidnap Aunt May and Daily Bugle secretary Betty Brant, holding them hostage in order to force Spider-Man to confront them. Spider-Man defeats the Sinister Six members one-by-one, mocking their decision to battle him individually instead of as a team in front of Doctor Octopus, the last one to be defeated.

### "The Return of the Sinister Six"

In The Amazing Spider-Man #334–339, Doctor Octopus recruits Electro, Sandman, Mysterio, and Vulture, along with the demonic Hobgoblin (since Kraven the Hunter had recently died), as part of his plan to take over the world. However, this was a trick, part of a larger plan by which Doc Ock alone would be the master of the world, by releasing a chemical into the atmosphere that would cause pain in anyone who attempted to use cocaine; he would then sell his cure for the chemical to the rich and powerful. Sandman, who at this point in his career had reformed and was blackmailed into joining, aids Spider-Man in defeating the Sinister Six, and ultimately stopping Doc Ock's plans to conquer the world. Because Octopus' chemical is eating away the ozone layer, Spider-Man has no choice but to release the cure into the atmosphere.

### "Revenge of the Sinister Six"

In Spider-Man #18-23, Electro, Mysterio, Vulture, and Hobgoblin reunite in a bid to take revenge on Doctor Octopus. To trick Sandman into joining them, they hit his foster family with a bomb, leading him to believe Doctor Octopus attacked them as punishment for betraying him. Sandman contacts Spider-Man and asks him to shadow the group as insurance against him being double-crossed. Doctor Octopus easily defeats the other members of the six with his newly reacquired adamantium arms, then zaps Sandman with a weapon that transforms his body into glass and beats Spider-Man nearly to death. When police surround the building, the other members of the Sinister Six agree to serve Doctor Octopus in exchange for his helping them escape. The assembled Sinister Six go off on a rampage, stealing advanced weapons and technology from several sources, including an alien dimension and a facility specializing in cybernetics. To again complete their quorum of six, they recruit Gog. Eventually, Spider-Man and several other heroes (including the Ghost Rider, Deathlok, Nova, the Hulk, and Solo) confront the villains as they are seizing a HYDRA base to gain access to deadly, world-devastating weapons. Most of the members are again incarcerated, but Vulture and Hobgoblin escape.

### Sinister Seven

A variation known as the Sinister Seven is formed by Hobgoblin to fight Kaine after he killed Doctor Octopus and the Grim Hunter (Kraven's son Vladimir). Hobgoblin's Sinister Seven includes the Beetle, Electro, Mysterio, Scorpia, the Shocker, and the Vulture. They finally find Kaine and a battle erupts. Spider-Man saves Kaine from being executed; the two then work together and defeat the Sinister Seven.

### Sandman's Sinister Six

Eventually, the Sandman (who had been turned back into a villain by his former ally the Wizard) and the second Mysterio (the original had committed suicide following his fight with Daredevil) form a new version of the Sinister Six, with Venom temporarily replacing Doctor Octopus and the other members consisting of Electro, the second Kraven the Hunter (another son of the dead original), and the Vulture. The Sandman uses the Sinister Six in order to get revenge on Doctor Octopus for turning him into glass in "The Revenge of the Sinister Six" storyline. The Sinister Six are defeated again, and Venom subsequently attacks the various members of the group after being betrayed by them. He nearly kills the Sandman and badly injures Electro and Kraven the Hunter before he and his symbiote are briefly separated from each other by the mysterious Senator Ward.

### Sinister Twelve

In Marvel Knights Spider-Man, Norman Osborn is unmasked to the public as the Green Goblin and imprisoned. Osborn contacts a group of supervillains who also bear grudges against Spider-Man, all of whom had been financed by Osborn's fortunes for years. Eager to retaliate, the villains agree to band together, and the Sinister Twelve is formed.
Mac Gargan is the de facto leader of the Twelve while Osborn is in prison, and he kidnaps Peter Parker's Aunt May and threatens to kill her if Spider-Man does not help Osborn escape from jail. Spider-Man, with help from Black Cat, breaks Osborn out only to be confronted by the Vulture, the Sandman, Electro, the Chameleon, the Lizard, Hydro-Man, the Shocker, Hammerhead, Boomerang and Tombstone. Osborn, now in the guise of the Goblin, introduces them as the Sinister Twelve.
Spider-Man and Black Cat are rescued by Captain America, Iron Man, Daredevil, Yellowjacket and the Fantastic Four. Furious, Goblin rockets away and kidnaps Mary Jane Watson and Spider-Man pursues him. Spider-Man and the Goblin clash upon a bridge (not the one where Gwen Stacy was killed). Finally, Osborn gives a vital clue as to Aunt May's whereabouts before being knocked into the river below. In the aftermath, Aunt May is found and saved. The rest of the Sinister Twelve are subdued by the other heroes and arrested.

### Civil War's Sinister Six

A new version of the Sinister Six apparently bands together during the Civil War storyline. The line-up consists of Doctor Octopus, Grim Reaper, Lizard, Shocker, Trapster and Vulture. They are stopped by Captain America and his Secret Avengers off-panel and discovered bound and subdued by S.H.I.E.L.D.

### "Big Time" Sinister Six

Following the events of the "Origin of the Species" storyline which involves Doctor Octopus assembling Spider-Man's enemies into targeting Harry Osborn's baby (who Doctor Octopus thought had some of Norman Osborn's DNA), only the Chameleon, Electro, Mysterio, the Rhino, and the Sandman remain with Doctor Octopus to reform the Sinister Six when the baby does not inherit Norman Osborn's DNA. Their first plot involves sending Micro-Octobots to blow up an Air Force base. This is prevented by Spider-Man, the Avengers, and the Fantastic Four.
Spider-Man and the Future Foundation stumble on a plot on a Caribbean Island by the Sinister Six which involves the use of a zombie pirate crew. During the fight with the Sinister Six, Spider-Man realizes that the Doctor Octopus, Electro, Rhino and Sandman that they are fighting are robots, while Mysterio and the Chameleon are the only real ones present. Meanwhile, the real Doctor Octopus infiltrates the Baxter Building to look for specific technology plans.
While the adult Avengers are dealing with the eruption of Mount Etna, Tigra and the Avengers Academy students learn that Electro has broken into a French laboratory. Once on the scene, the students discover that Electro is accompanied by the rest of the Sinister Six. The Sinister Six overpower the students and Doctor Octopus steals a device containing self-sustaining power. Doctor Octopus and the Sinister Six later fight the Intelligencia where the Chameleon had infiltrated the group disguised as Klaw. After the Intelligencia members are defeated, the Sinister Six steal their Zero Cannon (a weapon which changes Earth's gravity field to send specific objects into space). Doctor Octopus later appears in a robot suit which would help to keep him alive.
Doctor Octopus and Mysterio coordinate the Octobots that have infiltrated the Apogee 1 Space Station and taken over some of the crew members. When Mysterio notices that some of the Octobots were disabled, Doctor Octopus orders the Octobots to finish their mission and then destroy the space station. When Spider-Man arrives on the Apogee 1 Space Station, Doctor Octopus pushes a button that starts to move the Apogee 1 Space Station close to Earth. After Apogee 1 Space Station is destroyed and the crew is evacuated by Spider-Man, the Human Torch and John Jameson, Doctor Octopus tells the rest of the Sinister Six that his master plan is about to begin.

#### Ends of the Earth

In the "Ends of the Earth" storyline, all of Doctor Octopus' preparations come to fruition in a plan to conquer the world. Doctor Octopus activates a giant antenna array called the Octahedral which, in turn, activates Earth-orbiting satellites he calls the Octavian Lens. The Lens works to speed up the greenhouse effect, which in turn heats up the Earth. Upon hacking into televisions around the world, Doctor Octopus describes what his satellites are doing, and shuts them down. He says he can save the world "at a price". At Palazzo Senatorio, an international gathering of world leaders and the planet's greatest minds meet to discuss Doctor Octopus's supposed offer to save the world. The Avengers crash the assembly and Spider-Man captures the Chameleon, who is at the meeting disguised as Vice President Al Gore. Spider-Man lets the Chameleon go, but he secretly places a Spider-Tracer on him, which allows Spider-Man and the Avengers to follow the Chameleon to the Mediterranean Coast where the rest of the Sinister Six is waiting. The Six subdue the Avengers, leaving only Spider-Man standing. Spider-Man is taken down when trying to gain control of Doctor Octopus's tentacles with his helmet.
The Sinister Six then leave the area, and Doctor Octopus issues his demands: control of 200 missile facilities (for use in his plan), as well as 2 billion dollars for each of the members of the Sinister Six. In response, Spider-Man contacts Horizon Labs for help. Doctor Octopus sends the Sandman to guard one of the missile facilities in the Sahara Desert. After Spider-Man, the Black Widow, and Silver Sable enter the facility and defeat the Sandman, Doctor Octopus contacts the U.N. once again and orders them to kill Spider-Man in retaliation. In a subsequent missile facility raid, Spider-Man and his allies manage to defeat the Rhino, but they are unable to capture him because they are attacked by S.H.I.E.L.D (under orders from the U.N., via Doctor Octopus's demands). Forced to flee, Spider-Man and his allies then attempt to rally support from Earth's other heroes after the Titanium Man alerts them to the fact that Doctor Octopus has been recruiting other villains. Tracking down a final facility, Spider-Man learns that Doctor Octopus has already launched all of his satellites. However, this is revealed to be a deception created by Mysterio and the Chameleon. Spider-Man defeats the Chameleon when he attempts to attack them in a "Doc-Ock" suit of armor. Spider-Man and his allies then convince Mysterio to help them track down Doctor Octopus's base. While they find the base, they also find themselves pitted against the 'new' Sinister Six—in the form of the mind-controlled Avengers.
Despite Doctor Octopus's confidence, the heroes prevail against their mind-controlled teammates; the Black Widow and Hawkeye are knocked out by Iron Man while he is still under Doctor Octopus's control. Spider-Man's new training, combined with Captain America subconsciously holding back, allows Spider-Man and Silver Sable to defeat Spider-Woman and Captain America, respectively. Finally, Mysterio uses an EMP generator to negate the Octobots controlling Thor, Iron Man and the Red Hulk. Now "Octobot" free, these remaining three Avengers set out to take out Doctor Octopus's missiles, while Spider-Man and Silver Sable confront Doctor Octopus in his base. The two are first met by the Rhino, who decides to drown himself and take Sable with him in an attempt to psychologically beat Spider-Man into submission, but Spider-Man musters his strength, manages to destroy Doctor Octopus's arms and equipment and ultimately hauls his foe away to a doctor.

### Marvel NOW!'s Sinister Six

As part of the Marvel NOW! event, the Superior Spider-Man (Doctor Octopus's mind in Spider-Man's body) encounters a new Sinister Six consisting of Boomerang, Overdrive, the Shocker, the Speed Demon, the Living Brain and the female Beetle that previously fought Captain America and the Black Widow. The group of villains attacks Horizon Labs, but the Superior Spider-Man defeats them, using a power-dampening field to disable their equipment. He is preparing to kill Boomerang when the still-living consciousness of Peter Parker stops him. Otto gives the villains to the NYPD and the EMTs upon their arrival.
This version of the Sinister Six (minus the Living Brain) then appears in its own series The Superior Foes of Spider-Man. The Sinister Six later assaulted the Owl's base. Overdrive and the Speed Demon were captured by the Owl and interrogated. The Beetle tried to blackmail the Owl into releasing them while covertly dialing for back-up. Unimpressed, the Owl got ready to execute her when reinforcements arrived in the form of Tombstone (who was revealed to be the Beetle's father). At one point to steal valuables from the Chameleon, including a portrait of Doctor Doom, the Sinister Six allied with the Owl, where they expand the group into a "Sinister Sixteen". Besides Boomerang, the Beetle, Overdrive, the Owl, and the Speed Demon, the group consists of the Armadillo, the Bi-Beast, the Clown, the Cyclone, the Human Fly, the Kangaroo, Man Mountain Marko, the Mirage, Scorcher, Shriek, the Spot and the Squid. The team eventually broke up after Boomerang had thoroughly screwed over everyone, including himself.

#### Superior Six

Following the deletion of Peter Parker's memories and acquiring the Raft as his new base which he renamed Spider-Island II, the Superior Spider-Man begins to collect former Sinister Six members and store them in his underwater lab with the implied intention to create a new team as the Superior Spider-Man. First, he acquired the sand grain that contained the Sandman's consciousness. When Electro returned to Earth after being hurled into space by Thor, the Superior Spider-Man enlisted Thor to help defeat Electro. The Superior Spider-Man then confiscated the Chameleon from S.H.I.E.L.D. custody. The Superior Spider-Man came across Mysterion (a villain that is dressed like Mysterio) robbing the bank. Upon defeating Mysterion, the Superior Spider-Man discovered that the villain he thought was Mysterio was not Quentin Beck, but an unnamed man who bought the Mysterio gear from the Hobgoblin. Finally, the Superior Spider-Man went up against the Vulture, who seeks to get even with the Superior Spider-Man for beating him up twice. The Superior Spider-Man managed to defeat the Vulture.
The Superior Spider-Man debuts with mind-controlled members as the supposedly-reformed "Superior Six" at the time when Lightmaster invades Alchemax to obtain an invention that would work in sync with his own light powers. The Superior Six ended up fighting the Wrecking Crew (who were hired by Lightmaster to assist him). Due to the second Sun Girl's widespread attack, the Superior Spider-Man lost control of the Superior Six and they attacked him. The Superior Spider-Man and Sun Girl had to team up to defeat them.

#### Sinister Sixty-Six

Mojo and the Chameleon abduct Spider-Man and his X-Men students and force them to star in a show which pits them against the Sinister Sixty-Six. The group, which is not seen in its entirety, consists of holographic stand-ins of various enemies of Spider-Man like the Beetle, Carnage, the Demogoblin, Doctor Octopus, the Duster, Electro, the Gibbon, the Green Goblin, the Grizzly, Hammerhead, the Hobgoblin, the Jackal, Jack O'Lantern, the Kingpin, Kraven the Hunter, the Sludge, the Lizard, Morbius the Living Vampire, Mysterio, the Puma, the Rhino, the Ringer, the Sandman, the Scorpion, the Shocker, Shriek, Tombstone, Vermin and the Vulture.

#### Swarm's Sinister Six

Spider-Man and the students of the Jean Grey School for Higher Learning encounter the eighth incarnation of the Sinister Six led by Swarm and consisting of the third 8-Ball, Delilah, Killer Shrike, the third Melter and the Squid. After Hellion defeated Swarm, the other members of the Sinister Six surrendered.

### Iron Spider's Sinister Six

Purchasing a recolored and modified version of the Iron Spider armor, Miles Morales' uncle Aaron Davis forms his incarnation of the Sinister Six consisting of Bombshell, the Francine Frye version of Electro, the Roderick Kingsley version of the Hobgoblin, Sandman, and Spot. Their first mission was to steal a decommissioned S.H.I.E.L.D. Helicarrier.

### Sinister Sixty

Spider-Man plays with a cancer patient named Nathan, where they envision that Nathan becomes Spider-Bite and they "fight" the Stilt-Man's Sinister Sixty who wish to obtain Spider-Bite's action figure of Spider-Man. The line-up consists of the Absorbing Man, the Big Man, the Black Cat, the Black Tarantula, Boomerang, Calypso, Carrion, Carnage, the Chameleon, the Demogoblin, Doctor Octopus, the Doppelganger, Electro, the Enforcers, Fusion, the Green Goblin, the Grey Goblin, Hammerhead, the Hobgoblin, Hydro-Man, Jack O'Lantern, the Jackal, Joystick, the Juggernaut, Kaine, the Kingpin, Kraven the Hunter, Kraven the Hunter II, Kraven the Hunter III, Lady Octopus, the Lizard, Mephisto, Mister Negative, the Molten Man, Morbius the Living Vampire, Morlun, Mysterio, the Raptor, the Rhino, the Sandman, Sasha Kravinoff, Scorpia, the Scorpion, Scream, Screwball, the Shocker, Shriek, Silvermane, the Sin-Eater, Alistair Smythe, Stunner, Swarm, the Tarantula, Venom, Vermin, and the Vulture. Spider-Man and Spider-Bite defeat the Sinister Sixty at Grand Central Station and keep the Stilt-Man from claiming the Spider-Man action figure.

### Sinister War

While Doctor Octopus is discovering clues to some of his missing memories, he exhumes an unexpectedly empty casket in a cemetery. Kindred sends one of his centipedes to enter Doctor Octopus' ear, rendering him unconscious.
In a lead-up to "Sinister War", Kindred tells Doctor Octopus that he can help him with his memories, but he will need to gather five more people. At an unknown beach, Doctor Octopus helps Sandman with his loss of direction and promises to solve Sandman's immortality problem. Upon building a special machine, Doctor Octopus resurrects Electro with his powers intact as Kindred comments on Electro's abilities while stating that Doctor Octopus is getting closer to his true self. Doctor Octopus and Electro find Kraven the Hunter in the Savage Land hunting a dinosaur. Electro shocks the dinosaur, and Doctor Octopus recruits Kraven the Hunter into the Sinister Six by promising him to hunt down the Lizard. Doctor Octopus coerces Curt Connors into using the Isotope Genome Accelerator on himself which separates him from his Lizard side. Kindred then completes the Sinister Six by having Mysterio join him as Kindred notes that his endgame with Spider-Man is approaching.
When the Savage Six attacks the world premiere of a film that Mary Jane Watson and a disguised Mysterio were involved in, the Sinister Six intervenes in order to get Mysterio in their ranks despite Spider-Man's intervention. Mysterio complies with Doctor Octopus and teleports Mary Jane away while Doctor Octopus knocks out Spider-Man. Kindred kept the Savage Six on the reserve should the Foreigner's group, the Superior Foes, and the Sinister Syndicate fail to eliminate Spider-Man. Badly wounded, Peter is relieved to find the Black Cat, Wolverine, and the Human Torch have arrived to help, unaware that they are Mysterio, the Lizard, and Electro in illusion disguises created by the former. The Lizard springs their trap too early by attacking Peter, much to Mysterio's annoyance. Peter fends off the Sinister Six until Doctor Octopus ensnares him with his tentacles. Peter attempts to appeal to Doctor Octopus' better nature, telling him that he is not like this anymore. Doctor Octopus briefly hesitates, but mounting pressure from the rest of the Sinister Six compels him to act, though this buys Peter enough time to break free. The Savage Six then attack the Sinister Six, giving Peter time to escape. Ultimately, Doctor Octopus knocks all the other villains out using Black Ant's technology when he determines that Kindred planted some of his centipedes in the brains of every villain present, Octavius declaring that he dislikes being used even if he declines to help Peter further.

## Other versions
### Age of Apocalypse

An alternate universe iteration of the Sinister Six appears in the "Age of Apocalypse" 10th anniversary limited series. This version of the group is assembled by Mister Sinister and consists of Cloak and Dagger, Sonique, Sauron, the Blob, and Phoenix.

### Avataars: Covenant of the Shield

A medieval fantasy-inspired iteration of the Sinister Six called the Six Most Sinister appear in Avataars: Covenant of the Shield #2, led by the Goblin King and consisting of the Huntsman, Jolt, Mysterium, Sandstorm, Talon, and Tentaclus. This version of the group operate a tollbooth in the Webwood.

### Marvel 1602

An alternate universe iteration of the Sinister Six from Earth-311 called the Sinister Sextet appears in The Amazing Spider-Man (vol. 4) #1, consisting of Canice Cassidy, Electro, the Hobgoblin, Karnov, Magus, and the Serpent.

### Marvel 2099

A future iteration of the Sinister Six from a Marvel 2099-related timeline appears in Spider-Man 2099 (vol. 3) #11-12, consisting of Venom 2099, the Goblin 2099, Doctor Octopus 2099, the Vulture 2099, Electro 2099, and the Sandwoman. After the Goblin is revealed to be a mole helping Spider-Man 2099, he is killed by Doctor Octopus and replaced with Venture.

### Marvel Zombies

* A zombified iteration of the Sinister Six make a minor appearance in Marvel Zombies: Dead Days, consisting of Doctor Octopus, the Green Goblin, the Vulture, the Sandman, Electro, and Mysterio.
* An alternate universe iteration of the Sinister Six appear in Marvel Zombies Return, consisting of Doctor Octopus, the Sandman, the Vulture, Mysterio, Electro, and Kraven the Hunter. This version of the group work for the Kingpin until all except the Sandman are attacked and converted by a dimension-hopping zombified Spider-Man.

### Secret Wars (2015)

Three iterations of the Sinister Six from Battleworld appear in "Secret Wars" (2015).
* The first iteration appears in issue #2 of the Spider-Verse tie-in, consisting of Doctor Octopus, Kraven the Hunter, the Scorpion, Mysterio, the Shocker, and the Vulture. This version of the group hail from the Battleworld domain of Arachnia and work for Mayor Norman Osborn. Additionally, the fugitive Spider-Gwen, Spider-UK, Spider-Man Noir, Spider-Girl, Spider-Man India, and Spider-Ham are referred to by Osborn as the Sinister Six.
* The second iteration appears in Amazing Spider-Man: Renew Your Vows (vol. 1) #2, consisting of Doctor Octopus, Kraven the Hunter, the Hobgoblin, Mysterio, the Shocker, and the Vulture. This version of the group hail from the Battleworld domain of the Regency, all wield advanced technology, and work for the Regent. Additionally, they are tasked with capturing naturally powered superhumans. After being tasked with capturing the recently resurfaced Spider-Man, Doctor Octopus is killed, the Hobgoblin is caught in an explosion, and the Vulture is incapacitated. In response, the Regent recruits the Beetle, Boomerang, and the Rhino to replace them, though the group is defeated by Spider-Man and the Avengers.

### Spider's Shadow

An alternate universe iteration of the Sinister Six appear in the Spider-Man: Spider's Shadow miniseries, formed and led by J. Jonah Jameson / Spider-Slayer and consisting of Doctor Octopus, the Rhino, Electro, Mysterio, and Kraven the Hunter. This version of the group was formed in response to Peter Parker fully bonding to his symbiote suit and killing or assaulting his enemies. After Eddie Brock kills Octavius in an attempt to join the group, Parker grievously injures him and kills the Rhino, Electro, and Mysterio before a burning building forces the symbiote off of Parker. Realizing he was wrong about him, Jameson saves Parker while Kraven retreats.

### Spider-Man: Reign

A possible future iteration of the Sinister Six called the "Sinner Six" appears in Spider-Man: Reign, consisting of the Scorpion, Electro, Mysterio, Kraven the Hunter, the Sandman, and Hydro-Man. This version of the group were forcibly recruited by New York's fascist mayor Mayor Waters via microchips implanted in their bodies that are rigged to detonate should they attempt to leave the city and tasked with killing Spider-Man in exchange for their freedom. Over the course of the series, Spider-Man defenestrates the Scorpion and kills Electro and Hydro-Man before subduing Kraven and Mysterio. While Spider-Man is confronting Waters, Sandman sacrifices himself to get the former the detonator.

### Spider-Man Adventures

An alternate universe iteration of the Sinister Six appears in the Spider-Man Adventures magazine, formed by Doctor Doom and consisting of Doctor Octopus, the Vulture, Electro, the Rhino, the Sandman, and Eddie Brock / Venom.

### Spider-Verse

A steampunk-themed iteration of the Sinister Six from Earth-803 called the Six Men of Sinestry appears in Spider-Verse #1 and the accompanying Spider-Man 2099 tie-in, led by the Green Goblin and consisting of Doctor Octopus, Electro, Kraven the Hunter, Mysterio, and the Vulture.

### Spider-Ham

An alternate universe iteration of the Sinister Six called the Swinester Six from Earth-8311 appear in the Spider-Ham 25th Anniversary Special, consisting of the Green Gobbler, Doctor Octopuss, Sandmanatee, Eelectro, the Buzzard, and Mysteriape.

### Ultimate Marvel

An alternate universe iteration of the Sinister Six from Earth-1610 called the Ultimate Six appears in the Ultimate Marvel imprint, initially consisting of the Sandman, Doctor Octopus, Kraven the Hunter, Electro, and the Green Goblin, with Spider-Man as a temporary member. This version of the group illegally altered their genetic codes, which led to them being defeated by Spider-Man and the Ultimates and incarcerated by S.H.I.E.L.D. They would later break out of prison and recruit the Vulture to help them seek revenge on Spider-Man. When Doctor Octopus starts to have second thoughts due to his and the Goblin's role in creating Spider-Man, the Goblin kills Doctor Octopus before the remaining members receive help from Elijah Stern. However, all but the Goblin are defeated by Spider-Man, Johnny Storm, Bobby Drake, and May Parker while Spider-Man eventually kills the Goblin.

### Ultimate Universe

An alternate universe iteration of the Sinister Six from Earth-6160 appears in Ultimate Spider-Man (vol. 3), led by Wilson Fisk and consisting of Mister Negative, Walter Hardy, Sergei Kravinoff, Mysterio, and the Mole Man. This version of the group control New York's criminal underworld via its boroughs, with Fisk controlling Manhattan, Negative Queens, Hardy the Bronx, Kravinoff Staten Island, Mysterio Brooklyn, and the Mole Man New York's underground. Additionally, Fisk forms the group to counter emerging vigilantes Spider-Man and the Green Goblin.

## In other media
### Television

* The Sinister Six, renamed the Insidious Six, appear in Spider-Man (1994). Formed in their self-titled episode and the episode "Battle of the Insidious Six", the Kingpin assembles Doctor Octopus, Mysterio, the Shocker, the Chameleon, the Rhino, and the Scorpion to help him settle a debt with his enemy Silvermane. When the group realize the connection between Peter Parker photographing Spider-Man, the Insidious Six overpower and unmask him due to the hero's temporary loss of powers at the time, only to assume Parker came to fight them himself because he could not find the real Spider-Man. Later on, Spider-Man is able to strategically defeat them when his powers partially return. The Insidious Six return in the five-part episode "Six Forgotten Warriors", with the Vulture replacing Mysterio, who died in a previous episode. They attempt to help the Kingpin unlock a doomsday machine, but the Chameleon betrays the group to help his foster father, the Red Skull. After the team is defeated again, it is disbanded for good and its members return to their own lives.
* The Sinister Six appear in The Spectacular Spider-Man. Introduced in the episode "Group Therapy", Doctor Octopus, Sandman, the Shocker, the Vulture, the Rhino, and Electro pool their resources together and organize a jail break via Hammerhead, then go after Spider-Man, though they are defeated by his symbiote suit. In the episode "Reinforcement", Doc Ock assumes the Master Planner alias and arranges for the Sinister Six's reformation, now with Kraven the Hunter and Mysterio replacing Shocker while Doc Ock himself oversees their work from the shadows. The Sinister Six are again defeated by Spider-Man, though only Mysterio is arrested as the others escaped before the police arrived. In the episode "Shear Strength", the remaining members help Doc Ock with his plan to take over the world by hacking into the FBI's servers, but Spider-Man thwarts them and captures Electro. After Sandman fakes his death in the episode "First Steps" and Spider-Man captures the Rhino in the episode "Accomplices", Spider-Man later defeats the Vulture and Doc Ock and sees them arrested in the episode "Gangland".
* The Sinister Six appear in Ultimate Spider-Man. Introduced in their self-titled episode, Doctor Octopus, Electro, Kraven the Hunter, the Rhino, the Beetle, and a mind-controlled Lizard attack Spider-Man. While he defeats them with help from his fellow S.H.I.E.L.D. trainees, the Lizard escapes while the others are arrested. In the episode "Return of the Sinister Six", Doc Ock reforms the team with the Scorpion replacing the Beetle and provides them all with high-tech armor made from stolen Oscorp technology, but they are defeated by Spider-Man and his team again, with help from Iron Patriot. Doc Ock spends the fourth season, Ultimate Spider-Man vs. the Sinister Six, secretly forming a Sinister Seven with help from HYDRA. While Spider-Man and the Web Warriors defeat and capture supervillains to thin out Doc Ock's potential candidates, the villain goes on to recruit Kraven, Electro, a demonic Green Goblin from another universe, Hydro-Man, and a mind-controlled Rhino; with Scarlet Spider serving as a mole within Spider-Man's team. The Sinister Seven is defeated by Spider-Man and his allies in the two-part episode "The New Sinister Six" after Scarlet Spider defects to the heroes' side, though Doc Ock escapes. In the two-part series finale, "Graduation Day", Doc Ock forms the Superior Sinister Six with Kraven, the Scorpion, and a mind-controlled Vulture, Rhino, and Crossbones mutated into a new Lizard to eliminate Spider-Man after learning his secret identity. Spider-Man defeats them once more, freeing the brainwashed villains from Doc Ock's control before persuading him to surrender.
* The Sinister Six appears in Spider-Man (2017). Introduced in the episode "The Rise of Doc Ock" Pt. 4, they were originally the Osborn Commandos, a fighting force brought together by Norman Osborn and consisting of Doctor Octopus, the Vulture, the Rhino, Alistair Smythe, and Steel Spider. However, Doc Ock goes rogue and places the team under mind control, re-branding the team as the Sinister Five. In the episode "Hobgoblin" Pt. 1, Doc Ock also places Spider-Man under mind control and has him join the team to make it the Sinister Six. However, Harry Osborn becomes the Hobgoblin and frees Spider-Man and the rest of the team from Doc Ock's control. All of the group's members are defeated and arrested by the end of the first season.

### Film
#### Amazing Spider-Man series

In December 2013, Sony announced two spin-offs of The Amazing Spider-Man franchise, The Sinister Six and Venom, with Drew Goddard attached to write and direct the former. Throughout the live-action film The Amazing Spider-Man 2, a line-up for the team was teased. During the end credits, weapons and technology belonging to the Rhino, the Vulture, Doctor Octopus, Mysterio, and Kraven the Hunter were revealed, confirming them as members, with the Green Goblin serving as the leader. However, this line-up is left to be debated as Goddard stated he wanted to adopt a more classic adaptation of the group which would have included Sandman and Doc Ock as the leader. The film was said to be a redemption story for the characters, and would probably not feature Spider-Man. As the Sinister Six's original goal, however, was to kill him, there would seem to be a chance that he would appear. The film was originally scheduled for release on November 11, 2016. However, following the announcement in February 2015 of a new Spider-Man franchise with Marvel Studios, the spin-offs were postponed and eventually canceled.

#### Marvel Cinematic Universe

In an email from Amy Pascal leaked during the Sony Pictures hack, Pascal revealed that she planned for Tom Holland's Spider-Man to appear in a Sinister Six film set in the Marvel Cinematic Universe dependent on the success of the then-upcoming licensing agreement with Marvel Studios.

#### Sony's Spider-Man Universe

Following the collaboration between Marvel Studios and Sony Pictures, many spin-offs that had been in development before were revived, with the first of these, the live-action film Venom, being released on October 5, 2018. Sony's December 2013 plans for their own expanded universe included a film based on the Sinister Six, with Drew Goddard attached to write and potentially direct. Goddard was confirmed to be directing the film in April 2014. The film was believed to have been canceled by November 2015 when Sony was focusing on its new reboot with Marvel. In October 2018, Goddard acknowledged that his script could eventually be used for a film. By December of the same year, producer Amy Pascal confirmed that the studio intends to use the script in an upcoming project and expressed the company's desire for the filmmaker to direct the film as well.
In the post-credits scene of Morbius (2022), Adrian Toomes from the MCU approaches Dr. Michael Morbius in an effort to form a team. The team is intended to be the Sinister Six, with director Daniel Espinosa expressing interest in having Norman Osborn be part of the group.
Following the financial failures of Madame Web and Kraven the Hunter, and the underperformance of Venom: The Last Dance, it was announced that Sony would cease making spin-off films that did not feature Spider-Man, most likely including this film.

### Video games

* The Sinister Six appear in Spider-Man: Return of the Sinister Six, consisting of Doctor Octopus, Electro, Sandman, Mysterio, the Vulture, and the Hobgoblin.
* The Sinister Six appear in Spider-Man 2: The Sinister Six, consisting of Doctor Octopus, Mysterio, Sandman, the Vulture, the Scorpion, and Kraven the Hunter.
* The Sinister Six appear in the interactive DOS game Spider-Man: The Sinister Six, consisting of Doctor Octopus, the Chameleon, Mysterio, the Hobgoblin, the Vulture, and the Shocker.
* A multiversal Sinister Six appear in Spider-Man Unlimited, consisting of several multiversal versions of the Green Goblin, the Vulture, Electro, Sandman, Doctor Octopus, and Mysterio. They came together to invade multiple dimensions and harvest iso-8 crystals, with an army of "Sinister Soldiers" aiding them in their conquest.
* The Sinister Six appear in Marvel: Avengers Alliance, consisting of Doctor Octopus, the Vulture, Mysterio, Kraven the Hunter, the Lizard, and Electro. They aim to capture a Spider-Man, many of whom have been gathering because of the threat of Karn of the Inheritors, and sacrifice them to Doctor Octopus' machine to hide their dimension from the threat of incursions.
* The Sinister Six appear in Lego Marvel Super Heroes, consisting of Doctor Octopus, Sandman, Mysterio, Kraven the Hunter, Electro, and Vulture.
* The Sinister Six appear in Marvel: Contest of Champions, consisting of Doctor Octopus, the Green Goblin, Venom, Electro, the Vulture, and the Rhino. They are hired by the Grandmaster to eliminate Spider-powered champions. The team re-appear in a promotional video, with Mysterio replacing Venom.
* The Sinister Six appear in Marvel: Future Fight, consisting of Mysterio disguised as Doctor Octopus, the Vulture, the Rhino, Kraven the Hunter, Sandman, and the Lizard. They collaborate with A.I.M., but are eventually defeated by Spider-Man and his allies.
* The Sinister Six appear in Marvel Strike Force, consisting of Doctor Octopus, the Green Goblin, the Rhino, Mysterio, the Shocker, and the Vulture. Additionally, Electro and Swarm appear as optional members.
* The Sinister Six appear in Marvel's Spider-Man, consisting of Doctor Octopus, Electro, the Rhino, the Scorpion, the Vulture, and Mister Negative. Everyone but Doc Ock were originally imprisoned at the Raft before the latter releases and recruits them in an attempt to exact revenge on his former business partner-turned-mayor, Norman Osborn. While he shares this goal with Mister Negative, he promises the others their greatest desires in exchange for their assistance. The group clashes with Spider-Man when he interferes, though they easily defeat him during their first fight. Following this, the Sinister Six split up to attack different Oscorp properties while Doctor Octopus secures the company's Devil's Breath virus and releases it in Times Square in an attempt to expose Norman's crimes, infecting numerous people and causing Manhattan to descend into chaos. After capturing the Vulture, Electro, the Rhino, and the Scorpion, Spider-Man defeats Mister Negative before he can steal the antidote for Devil's Breath, but Doctor Octopus escapes with it and Norman. Spider-Man is eventually able to save Norman, reclaim the antidote, and defeat Doctor Octopus. By the end of the game, the Sinister Six are re-captured and re-imprisoned at the Raft, although their mission was a partial success, as Norman resigns from the mayor's office out of shame.
* The Sinister Six appear in Marvel Ultimate Alliance 3: The Black Order, consisting of the Green Goblin, Doctor Octopus, Sandman, Mysterio, Electro, and Venom. The Goblin freed the other members from the Raft after obtaining the Time Stone and they took over the prison. After a team of heroes, including Spider-Man, arrive at the prison to secure the inmates, Venom defects to the heroes' side at Spider-Man's behest while the remaining Sinister Six members are defeated and imprisoned once more.

### Miscellaneous

* The Sinister Six appear in Adam-Troy Castro's trilogy of Spider-Man novels, consisting of Doctor Octopus, the Vulture, Electro, Mysterio, the Chameleon, and an original character called Pity. This version of the group is formed by the Gentleman, who wishes to kill Peter Parker as revenge for the actions of his parents, Richard and Mary Parker, in the 1960s and cause a global financial collapse via an electromagnetic generator powered by Electro to erase all digital records and an ink-destroying catalyst to erase all paper records. The Vulture, Electro and Mysterio are defeated before the generator can be activated and Spider-Man convinces Pity to help him find the Gentleman when he realizes that Doctor Octopus will seek revenge on him for his arrogance, only to learn that the Chameleon had already killed the Gentleman for the same reason.
* The Sinister Six appear in Spider-Man: Turn Off the Dark, consisting of Electro, Carnage, Swarm, Kraven the Hunter, the Lizard, and an original character called Swiss Miss. This version of the group were all originally research scientists who were transformed by the Green Goblin as punishment for abandoning Osborn Industries and to destroy Spider-Man.
* The Sinister Six appear in Marvel Universe Live!, consisting of the Green Goblin, Doctor Octopus, the Rhino, the Lizard, Electro, and the Black Cat. They seek to claim a fragment of the recently-shattered Cosmic Cube, only to be defeated by Spider-Man and Thor.
* The Sinister Six appear in the "Return of the Sinister Six" expansion pack for the Marvel United CMON Limited board game, consisting of Doctor Octopus, Electro, Kraven the Hunter, Mysterio, the Sandman, and the Vulture.