# U.S. Route 101 in California

U.S. Route 101 (US 101) is a major north–south United States Numbered Highway, stretching from Los Angeles, California, to Tumwater, Washington. The California portion of US 101 is one of the last remaining and longest U.S. Routes still active in the state, and the longest highway of any kind in California. US 101 was also one of the original national routes established in 1926. Significant portions of US 101 between the Los Angeles area and the San Francisco Bay Area follow El Camino Real, the commemorative route connecting the former Alta California's 21 missions.
Although the highway has been superseded in overall importance for transportation through the state by Interstate 5 (I-5), US 101 continues to be the major coastal north–south route that links the Greater Los Angeles Area, the Central Coast, the San Francisco Bay Area, and the North Coast (Redwood Empire). Generally referred to as "101" by residents of Northern California, in Southern California it is often called "The 101" (pronounced "the one oh one"). The highway has portions designated as the Santa Ana Freeway, the Hollywood Freeway, the Ventura Freeway, South Valley Freeway, and Bayshore Freeway, as well as El Camino Real in many non-freeway segments. The Redwood Highway, the 350-mile-long (560 km) northernmost segment of the highway, begins at the Golden Gate and passes through the world's tallest and only extensive preserves of virgin, old-growth coast redwood trees.

## Route description

The entirety of US 101 in California is designated as Route 101 in the state highway system, and is defined as such in section 401 of the California Streets and Highways Code:
   Route 101 is from:
   (a) Route 5 near Seventh Street in Los Angeles to Route 1, Funston approach, and, subject to Section 72.1, the approach to the Golden Gate Bridge in the Presidio of San Francisco via Santa Barbara, San Luis Obispo, and Salinas.
   (b) A point in Marin County opposite San Francisco to the Oregon state line via Crescent City.
The definition purposely omits the segment crossing the Golden Gate Bridge, as it is maintained by the Golden Gate Bridge, Highway and Transportation District and is not part of the state highway system. As a result, there is no US 101 or SR 1 signage on the bridge.
US 101 is part of the California Freeway and Expressway System, and is part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration.
Portions of US 101 are eligible to be included in the State Scenic Highway System. It is officially designated as a scenic highway by the California Department of Transportation (Caltrans) from Goleta to Las Cruces in Santa Barbara County, and through Del Norte Coast Redwoods State Park in Del Norte County. This designation means that there are substantial sections of highway passing through a "memorable landscape" with no "visual intrusions", where the potential designation has gained popular favor with the community.

### Los Angeles to Ventura

The south terminus of US 101 is in Los Angeles, about one mile (1.6 km) east of downtown Los Angeles at the East Los Angeles Interchange, also known as the "Commuters' Complex". This southernmost portion is named the Santa Ana Freeway, inheriting that title as the northerly extension of the roadway now known as I-5. US 101 heads north for 2 miles (3.2 km) before merging with the western end of the San Bernardino Freeway (I-10).
After merging with westbound traffic from the San Bernardino Freeway (I-10), US 101 then proceeds northwest via the Downtown Slot under the northern edge of Los Angeles' Civic Center to State Route 110 (SR 110) at the Four Level Interchange. From here, US 101 becomes the Hollywood Freeway. It then passes through the L.A. neighborhoods of Echo Park, Silver Lake, and Los Feliz and heads to Hollywood and up through the Cahuenga Pass before reaching the San Fernando Valley.
US 101 passes right next to the Universal Studios Hollywood and then intersects with SR 134 and SR 170 at the interchange known as the Hollywood Split. Here, the alignment of US 101 shifts to the alignment of SR 134 (i.e. heading northbound, the road's alignment turns left, or westbound) and thereafter is referred to as the Ventura Freeway until it reaches Ventura. Though confusing, the "Hollywood Freeway" name continues northward from this interchange on SR 170, and the "Ventura Freeway" name continues eastward to SR 134.
From the Hollywood Split, US 101 is an east–west highway (until it reaches Gaviota State Park in Santa Barbara County where it shifts back to a north–south alignment). It meets with I-405 in Sherman Oaks. The east–west geographical alignment of the Ventura Freeway and the north–south designation which appears on the freeway signs can be confusing to visitors; the same freeway entrance can often be signed as "101 North" and "101 West"; this is most common in the San Fernando Valley where the local E/W signing does not match the Caltrans' proper statewide N/S designation.
After the Conejo Grade, which is a 7% grade incline, the freeway enters the Oxnard Plain and runs concurrent with SR 1 for the first time. Upon reaching Ventura, there is an interchange with SR 126, which runs east to Santa Clarita.

### Central Coast

North of Santa Barbara, US 101 switches intermittently between freeway and expressway status (i.e. there is occasional cross-traffic), but there are no traffic signals until San Francisco. From Ventura and through Santa Barbara, US 101 closely follows the Gaviota Coast (generally no more than one to two miles [1.6 to 3.2 km] from the shore) until Gaviota State Park, about 23 miles (37 km) west of Goleta. At Gaviota State Park, the highway shifts back from an east–west highway to a north–south alignment. About one mile (1.6 km) north of this point, the northbound lanes pass through the Gaviota Tunnel.
A few miles north of the Gaviota Tunnel, SR 1 splits from US 101 and heads northwest, running along the Pacific coastline parallel and to the west of US 101. US 101 passes through Buellton, Los Alamos, Orcutt, Santa Maria, and Nipomo. South of Santa Maria, US 101 widens from a four-lane highway to a six-lane freeway. SR 166 joins US 101 for about 3 miles (4.8 km) before splitting just north of the city limits, while US 101 continues as a four-lane freeway before reverting to expressway status north of Nipomo.
Farther north, SR 1 rejoins US 101 between Pismo Beach and San Luis Obispo. Then US 101 takes an inland route through the Salinas Valley, while Highway 1 heads northwest, running along the Pacific coastline in California, parallel and to the west of US 101.
A steep segment (7% grade) between San Luis Obispo and Atascadero is known as the Cuesta Grade. North of Atascadero, the highway joins SR 46 for about three miles (4.8 km) through Paso Robles.
From Paso Robles to Salinas, US 101 is an expressway known as the Salinas River Valley Highway, since the Salinas River Valley extends from Santa Margarita to the SR 156 junction in Prunedale. US 101 resumes freeway status between San Miguel and King City, bypassing the smaller towns of Camp Roberts, Bradley, and San Ardo, as well as the San Ardo Oil Field about five miles (8.0 km) south of San Ardo. Near this point, the wide agricultural bottomlands of the Salinas Valley begins. North of King City, US 101 once again switches intermittently between freeway and expressway status, passing through Greenfield, Soledad, Gonzales, and Chualar before reaching Salinas. Shortly after leaving Salinas, US 101 joins SR 156 in Prunedale for about eight miles (13 km). After crossing the San Benito County line, SR 156 splits from US 101 near San Juan Bautista while US 101 continues northward mostly as a four-lane highway until it reaches Gilroy.

### San Francisco Bay Area

US 101 crosses the Pajaro River into Santa Clara County as a four-lane highway, with an interchange at SR 25 a few miles later. Upon reaching Gilroy, it becomes the South Valley Freeway (as in South Santa Clara Valley), and at the same time, it expands to three lanes in each direction. It then enters Silicon Valley when reaching Morgan Hill, and shortly afterwards expands to four lanes in each direction, with an HOV lane in the middle, before reaching San Jose. From San Jose to San Francisco, US 101 is known as the Bayshore Freeway as it passes through Palo Alto and the other major communities along the San Francisco Peninsula.
US 101 is called the James Lick Freeway, named for James Lick, a philanthropist, from the San Francisco county/city line, through the interchange with I-280 at the Alemany Maze, until the junction with the San Francisco Skyway (I-80) and the Central Freeway near the city's Civic Center. US 101 continues in a northwestern direction on the Central Freeway, and then leaves the freeway, on Mission Street (northbound) and South Van Ness Avenue (southbound), to run north on Van Ness Avenue. At the intersection of Van Ness Avenue and Lombard Street, US 101 heads west on Lombard Street, and then on Richardson Avenue, entering The Presidio, where it becomes a divided highway again (the Presidio Parkway). It is then joined by Route 1 before approaching and crossing the Golden Gate Bridge.
From San Francisco north the highway is heavily traveled by commuters through to Windsor, just north of Santa Rosa. North of the Golden Gate Bridge, US 101 enters Marin County and is known as the Redwood Highway. After crossing the bridge, US 101 climbs the Waldo Grade and passes through the Robin Williams Tunnel, the only one of its kind in 300 miles (480 km) (the other being the Gaviota Tunnel in Santa Barbara County). Upon exiting the tunnel, it passes above the hillside town of Sausalito and descends to Richardson Bay, where SR 1 splits from the freeway and heads to the coast. US 101 then passes through Mill Valley, Corte Madera, Larkspur, San Rafael and Novato, before entering Sonoma County. The section between Novato in Marin County and Petaluma in Sonoma County changes from its original six or eight lanes through Marin to four lanes, creating a bottleneck, and is thus called the "Novato Narrows" by locals. The Narrows continue up to the county line between Marin and Sonoma Counties. The entire area between Novato and Petaluma is also the voter approved Novato–Petaluma Community Separator, which forbids most development.
Upon entering Sonoma County, the freeway widens again to six lanes from the county line to Windsor, passing through Petaluma, Cotati, Rohnert Park, and Santa Rosa. Upon reaching Windsor, the freeway returns to two lanes in each direction, crossing the Russian River in Healdsburg and then following the river up the Alexander Valley. SR 128 joins US 101 in the town of Geyserville before splitting just north of Cloverdale. US 101 then heads up a steep hill just before leaving Sonoma County and entering Mendocino County.

### North Coast

US 101 crosses into Mendocino County as a freeway for one mile (1.6 km), but then narrows to an expressway through the Russian River canyon and eventually a two-lane road south of Hopland, the first time since leaving San Francisco. Just before reaching Ukiah, US 101 becomes a four-lane freeway. In the community of Calpella, SR 20 merges with US 101 for the next 15.5 miles (24.9 km) to Willits. The freeway portion ends as the combined US 101 and SR 20 ascend the 1,956-foot (596 m) Ridgewood Summit, the highest elevation along the route's 808-mile-long (1,300 km) trek through California. As US 101 resumes freeway status just south of Willits, SR 20 splits from US 101 shortly before it suddenly reverts to a 2-lane undivided freeway and eventually a highway north of Willits.
US 101 then widens to a four-lane expressway until the intersection with the western portion of SR 162, where it reverts to a two-lane road. North of Laytonville, US 101 ascends Rattlesnake summit (1,796 feet or 547 metres) before a descent to follow the South Fork Eel River and Eel River all the way to Fortuna near the mouth of the river. About 12 miles (19 km) northwest of Laytonville, US 101 becomes an undivided freeway near the community of Cummings. SR 271 is the old portion of US 101 through this area. At Leggett, US 101 meets SR 1 for the last time, and from this point until Piercy, US 101 runs along a section of highway with frequent landslides. Caltrans bypassed the most difficult section in 2009 with unique construction of two bridges known collectively as the Confusion Hill Bridges. This project, funded by an emergency act from the State Legislature, moved the highway across the Eel River away from the troubled spots to prevent disruption in commerce and travel from infrequent, but costly, winter closures on the main transportation route to the far North Coast. North of Piercy, the freeway portion again ends and the road narrows down to two lanes, before another stretch of divided highway.
Arriving in Humboldt County, another narrow two-lane portion of US 101 bisects Richardson Grove State Park. Because of the narrow lanes and the redwood trees that tower over this segment of the highway, standard-sized trucks in compliance with the Surface Transportation Assistance Act (STAA) are prohibited through the park. Just after the park boundary, the highway switches to a short undivided freeway and then eventually a divided freeway just before reaching Garberville. North of Garberville, US 101 reverts to an undivided freeway, which continuing north by northwest, passes through the 53,000-acre (210 km$^2$) Humboldt Redwoods State Park, California's third largest State Park and the site of the largest remaining Redwood old growth forest in the world. A preserved portion of the original, bypassed highway route, known as the Avenue of the Giants for the huge, centuries-old redwood trees, parallels the highway for over 30 miles (48 km) in southern Humboldt County. US 101 again switches to another stretch of divided freeway near the town Pepperwood before reverting to a short, 2-mile (3 km) expressway just north of Stafford. A short freeway then runs through Rio Dell before another short, 3-mile (5 km) expressway.
Shortly before reaching the western terminus of SR 36, US 101 becomes a freeway again between Fortuna and Eureka. North of Humboldt Hill, the road enters the City of Eureka (a potential new freeway cutting through or bypass of the city was successfully blocked repeatedly). As the route traverses Eureka, the southern portion is known as "Broadway" and then as it bears east along Humboldt Bay, the Highway is aligned on a one-way couplet (4th and 5th streets). Five miles (8.0 km) later the highway leaves Eureka's northern city limit and continues north. The expressway style section between Eureka and Arcata, which is also a safety corridor, is named the "Michael J. Burns Freeway," in honor of the State Senator who was a proponent of California's Highways. The highway becomes an unobstructed freeway south of the center of Arcata. Proceeding north it passes the junction for SR 299 (also the western terminus for that route), in the Valley West (northernmost) part of the college town.
The highway continues north as it skirts westerly around McKinleyville on a high bluff north of the Mad River. As the highway reaches Clam Beach (a county park), motorists get their first magnificent full view of the Pacific Ocean north of the Golden Gate. North of Trinidad, the highway narrows to one lane in each direction after crossing Big Lagoon to pass inland of Stone Lagoon and follow the coastal bar between Freshwater Lagoon and the Pacific Ocean south of Orick. It becomes a 14-mile (23 km) undivided freeway through Redwood National and State Parks running inland east of the Prairie Creek Redwoods State Park boundary. The freeway narrows to one lane in each direction at the Klamath River before losing its freeway designation in Klamath. The original placement of the highway near giant Coast Redwoods led to increased awareness of the destruction of the redwoods after decades of extensive logging, which ultimately led to the establishment of Redwood National Park in 1968. The original highway segment through Prairie Creek Redwoods State Park is now a scenic alternate similar to Avenue of the Giants, named Newton B. Drury Scenic Parkway in honor of the fourth director of the National Park Service and executive director of the Save-the-Redwoods League
North of the town of Klamath just inside Del Norte County, the highway closely follows the Pacific coast again. In Crescent City, US 101 once again separates into a one-way couplet (L and M Streets) for nine blocks. As it leaves Crescent City, US 101 becomes a divided freeway for the last time in California (built slightly to the west of the original two-lane alignment, now called Parkway Drive). As the 3-mile divided freeway portion ends, US 101 intersects the southern terminus of US 199, which heads northeast as the Redwood Highway, passing through the Collier Tunnel and terminating in Grants Pass, Oregon. US 101 (no longer called the "Redwood Highway" at this point) is reduced to two lanes and continues north along the California coast until it reaches the Oregon border.

## Tolls
### Express lanes

High-occupancy toll (HOT) lanes along US 101 between SR 237 in Mountain View and Whipple Avenue in Redwood City opened on February 11, 2022. These express lanes were extended to I-380 in San Bruno on March 3, 2023, and are planned to be extended further south to I-880 in San Jose in Fall 2026.
As of January 2025, the HOT lanes' hours of operation is weekdays between 5:00 am and 8:00 pm; they are otherwise free and open to all vehicles at other times. Solo drivers are tolled using a congestion pricing system based on the real-time levels of traffic. Two-person carpools and clean air vehicles with a solo driver are charged 50 percent of the posted toll. Carpools with three or more people and motorcycles are not charged. All tolls are collected using an open road tolling system, and therefore there are no toll booths to receive cash. Each vehicle using the HOT lanes is required to carry a FasTrak Flex transponder with its switch set to indicate the number of the vehicle's occupants (1, 2, or 3+). Those with clean air vehicles need to apply for a special FasTrak CAV tag. Solo drivers may also use the FasTrak standard tag without the switch. Drivers without any FasTrak tag will be assessed a toll violation regardless of whether they qualified for free.
The segment of the express lanes in Santa Clara County is co-administered by the Santa Clara Valley Transportation Authority (VTA) while the segment in San Mateo County is co-administered by the separate San Mateo County Express Lanes Joint Powers Authority, and therefore drivers will see two separate toll charges if they cross the county line.

### Golden Gate Bridge

Tolls are collected only for southbound traffic on the Golden Gate Bridge headed to San Francisco. All-electronic tolling is also used on the bridge, and can be paid by either a FasTrak transponder or license plate tolling. The high-occupancy vehicle (HOV) lane leading to the bridge requires a car with three or more people.

## History
### Juan Bautista de Anza National Historic Trail

The US 101 Highway is part of the auto tour route of the Juan Bautista de Anza National Historic Trail, a National Park Service unit in the United States National Historic Trail and National Millennium Trail programs. In 2005, Caltrans began posting signs on roads that overlap with the historic 1776 Juan Bautista de Anza trail route, so that California drivers can now follow the trail.

### Historic route: San Diego to Los Angeles

Instead of terminating in Los Angeles, US 101 once continued all the way south through San Diego to the Mexico–United States border in San Ysidro. However, this part was decommissioned on July 1, 1964, in favor of I-5. Though much of U.S. Route 101 has been superseded by I-5, several street segments of former Route 101 exist.

#### Historic route in San Diego County

Much of the route in northern San Diego County is County Route S21; this includes Coast Highway in Oceanside, Carlsbad Boulevard in Carlsbad, Coast Highway 101 in Encinitas, Camino del Mar in Del Mar, and Torrey Pines Road in Torrey Pines. In San Diego, one alignment entered La Jolla Village on La Jolla Blvd, while a newer alignment went through Rose Canyon under what is now I-5. Roads followed by US-101 in San Diego included Mission Bay Drive, Pacific Hwy, Harbor Drive and Main Street. It ran along National City Blvd in National City, Broadway in Chula Vista and Beyer Blvd in San Ysidro.

#### Oceanside–Carlsbad freeway bypass

By the early 1950s, traffic had become very heavy on US 101 through Oceanside and Carlsbad. The US 101 freeway bypass (Oceanside-Carlsbad freeway bypass) was built in 1953 and completed in 1955 by the California Department of Public Works (now Caltrans) and brought up by the San Diego Highway Development Association on a US 80/US 101 discussion on how to resolve the huge traffic loads on US 101 in Oceanside. Today it is part of I-5 and Palomar Airport Road. It follows I-5 from Coast Highway (former Hill Street exit) in Oceanside to Palomar Airport Road in Carlsbad. From there the US 101 bypass went onto Palomar Airport Road to merge with US 101 Bus. on Carlsbad Boulevard. As it approached the Coast Highway/SR 76 exit on southbound I-5 in Oceanside, US 101 Bus. split off. US 101 Bus. followed the original US 101 through downtown Oceanside and Carlsbad as former Hill Street/Carlsbad Boulevard (CR S-21) while the US 101 freeway followed modern I-5 and Palomar Airport Road. The south end of the freeway bypass is Carlsbad Boulevard and Palomar Airport Road and the north end is I-5 and the Coast Highway/SR 76 exit. The south end was modified after US 101 was decommissioned between the East Los Angeles Interchange in Los Angeles and the Mexican border in San Ysidro. This freeway construction by the California Department of Public Works put US 101 on an all new highway route alignment to relieve Oceanside and Carlsbad of their very heavy bumper-to-bumper burdensome traffic problem. Also before the bypass in the 1950s, US 101 followed North Coast Highway (formerly Hill Street) from San Luis Rey Mission Expressway (SR 76 and north end of the Oceanside–Carlsbad freeway bypass) to Harbor Drive. From there it followed Harbor Drive to Vandergrift Boulevard, San Rafael Drive, and the freeway onramp for I-5 north near the Camp Pendleton north entrance guardhouse gate. It merges with the I-5 northbound onramp to shoot onto the southbound lanes of I-5 to follow the freeway lanes all the way to Las Pulgas Road in Camp Pendleton.

#### Historic route in Orange and Los Angeles Counties

An old orphaned alignment of US 101, that ran through the cities of Mission Viejo, Laguna Niguel, San Juan Capistrano, Dana Point, and San Clemente, was located in south Orange County. The old roadway, from a dead end just west of I-5 and east of the railroad tracks in Mission Viejo to Cristianitos Road in San Clemente, followed Camino Capistrano, Doheny Park Road, Coast Highway and El Camino Real. It had interchanges with I-5 and California State Route 1. It was replaced by the San Diego freeway (which US 101 became part of it in 1958) and finally replaced by I-5 in 1968.
In northern Orange County, US 101 followed Harbor Boulevard. U.S. Route 101 left Orange County, traversed southeast Los Angeles County, and entered the City of Los Angeles along Whittier Boulevard.

### El Camino Real: Los Angeles to San Francisco

Significant portions of US 101 from its southern terminus to the San Francisco Bay Area is designated as the Royal Road or El Camino Real. The commemorative route connects the former Alta California's 21 missions.
A former route of the highway over the Gabilan Range on the San Juan Grade to San Juan Bautista was bypassed in a 1932 realignment. Instead, shortly after leaving Salinas, US 101 joins SR 156 in Prunedale for about eight miles (13 km) as it crosses the mountains further north, through the Prunedale Cutoff.
Before the Golden Gate Bridge was completed in 1937, there was regular vehicle ferry service across the Golden Gate strait, running from the Hyde Street Pier to Sausalito. Under the California Streets and Highways Code § 401, the Golden Gate Bridge is legally not part of US 101. The portion of US 101 starting from Los Angeles ends at "the approach to the Golden Gate Bridge" and then resumes at "a point in Marin County opposite San Francisco" to the Oregon state line. The bridge itself is maintained by the Golden Gate Bridge, Highway and Transportation District instead of Caltrans.
From the 1940s to 1991, various segments of US 101 between Los Angeles and San Francisco were upgraded to either a freeway or expressway. In the Los Angeles area, the first segment of the Hollywood Freeway through the Cahuenga Pass opened in 1940, while the segment from the San Fernando Valley to Downtown Los Angeles opened in 1954, replacing Cahuenga Boulevard. The Ventura Freeway then opened in 1960, replacing Ventura Boulevard. The segment of the original two-lane alignment between Emma Wood State Beach north to the Mobil Pier Undercrossing near Sea Cliff, which followed the historic Rincon Sea Level Road, was the re-signed as part of SR 1.
The last traffic signals along the route between the Los Angeles area and the San Francisco Bay Area were removed in 1991 when the section through downtown Santa Barbara was constructed to freeway standards after years of disagreement over the impact that the original elevated design would have on the community.
In the San Francisco Bay Area, US 101 was originally divided. US 101W followed the same general right-of-way of today's US 101 through the region, primarily along what was originally signed as Bayshore Boulevard. US 101E then generally followed the right-of-way taken by today's I-880 from San Jose to Oakland, then across the Carquinez Bridge to follow what is now SR 37, joining US 101W. The US 101E designation was removed by the 1940s and became SR 17 (later designated as I-880 and the westernmost section I-580), running from San Jose to Oakland and then across the Richmond–San Rafael Bridge. Meanwhile, Bayshore Boulevard was later redesignated as the US 101A bypass and then eventually upgraded to what is now the Bayshore Freeway. The first stretch that was completed between Redwood City and South San Francisco was the Bay Area's first freeway when it opened in 1947. After the entire Bayshore Freeway was completed in the early 1960s, the old alignment along the peninsula was renumbered and renamed as SR 82/El Camino Real.
Various other freeway or expressway bypasses along the California Central Coast were also built. In 1991, the last traffic signal along US 101 between Los Angeles and San Francisco was taken down in Santa Barbara. The primary control city that is listed on freeway signs along northbound US 101 through the Central Coast region remains San Francisco.
As the result of freeway revolts in San Francisco in the 1950s, a direct freeway connection through the city to the Golden Gate Bridge has never been built. The Central Freeway was completed to extend from the Bayshore Freeway to Turk Street in 1959, before the San Francisco Board of Supervisors voted to remove the remainder of the Central Freeway and most other proposed freeways from the city's highway plan. For decades, southbound traffic on US 101 flowed on the one-way Turk Street from Van Ness Avenue to the Central Freeway, while northbound traffic used the parallel Golden Gate Avenue. After the 1989 Loma Prieta earthquake damaged the structure, the segment of the Central Freeway north of Market Street was replaced with the surface-level Octavia Boulevard; traffic on US 101 was then eventually re-routed to exit south of that at Mission Street/South Van Ness Avenue. With no direct freeway along US 101 through the City of San Francisco, the old US 101E/I-880/I-580 route remains as a faster bypass through the Bay Area.
In the wake of the dot-com bubble expansion, the segment of US 101 between Morgan Hill and San Jose, also known as the Sig Sanchez Freeway, expanded to eight lanes between Cochrane Road and SR 85 exits between 2001 and 2003 and a new interchange at Bailey Avenue, which had been planned since the 1970s, opened in 2004. Originally, the ten-mile segment (16 km) was only four lanes (it was planned to have six lanes when opened in 1984). The rebuilt segment was to alleviate the consistent congestion that had expanded as far south as Masten Avenue coming from Gilroy, and as far north as Bernal Road coming from San Jose. Traffic now typically only runs slow between the Bailey Avenue and East Dunne Avenue exits.
The interchange at the beginning of I-280 and I-680 in San Jose was constructed years before its completion. The three flyovers, with no on ramps or off ramps connecting them stood at 110-foot-tall (34 m) over US 101 for years in the 1970s (the SR 87/I-280 interchange also had this at the same time). It became the butt of many local jokes. The highlight prank occurred in January 1976, when a 1960 Chevrolet Impala was placed on the highest bridge overnight, where it obviously would be impossible to drive. The following day, San Jose City Councilman Joe Colla was photographed standing next to the car, a photo which was circulated across many newspapers. It has been suggested this stunt helped lead to funding to complete the freeway. In 2010, the interchange was named the Joe Colla Interchange.

### Redwood Highway: Marin County to Del Norte County

An abandoned segment of the Redwood Highway, US 101, located in the Redwood National and State Parks near Klamath was added to the National Register of Historic Places in 1979.
Freeway segments along the Redwood Highway portion of US 101 are not as prevalent as along the Los Angeles-San Francisco route. A notable segment of the old US 101 alignment is SR 254, also known as the Avenue of the Giants, in Humboldt Redwoods State Park. The freeway bypassing this scenic route, surrounded by towering Coast Redwoods, was completed in 1960. Several bridges along the segment of highway running along the Eel River were destroyed during the Christmas flood of 1964.
A freeway bypass of Cloverdale was constructed in the early 1990s, requiring the relocation of segments of the Northwestern Pacific Railroad. The new 4-mile-long (6.4 km) roadway along with new frontages and relocated railroad were completed at a cost of $40 million ($84.9 million in 2024 adjusted for inflation). The highway opened over two weeks in March 1994. The old routing through town is on Cloverdale Boulevard.
Construction on a freeway segment bypassing Willits began in 2013. The bypass around Willits remained controversial because the intended route goes through protected wetlands. Construction was halted by US Army Corps of Engineers in June 2014 and work restarted the following month after Caltrans committed to extensive mitigation of the project. The 5.9 mi (9.5 km) bypass around Willits opened to traffic in November 2016. The bypass included a 1.1 mi (1.8 km) viaduct going over a flood plain. The freeway segment cost $459 million to complete ($601 million in 2024 adjusted for inflation), 50% more than what Caltrans first reported when it opened. Because the US 101/SR 20 intersection was originally inside Willits' city limits, SR 20 was then extended along the southern bypassed portion of former US 101. The northern bypassed portion of former US 101 in unincorporated Mendocino County has yet to be turned over to local maintenance, and therefore still exists within the state highway system under the unsigned designation of Route 101U (for "unrelinquished").
The city of Eureka has long resisted a freeway through it.

## Future

The Wallis Annenberg Wildlife Crossing is a vegetated overpass spanning the Ventura Freeway and Agoura Road at Liberty Canyon in Agoura Hills. Once built, it will be one of the largest urban wildlife crossings in the United States, connecting the Simi Hills and the Santa Monica Mountains over a busy freeway with ten traffic lanes (including exit lanes).
The Richardson Grove section of US 101 has been proposed for a bypass for many years, but Caltrans conducted a study in 2000 which stated that a bypass was not cost effective and recommended realignment of US 101 within the redwood grove instead to accommodate modern-sized trucks in compliance with the Surface Transportation Assistance Act (STAA).

## Names and memorials

Urban portions of the route in Southern California are named the Santa Ana Freeway, Hollywood Freeway, and Ventura Freeway at various points between East Los Angeles and Carpinteria, California. In 2008, the portion of US 101 that runs from the Conejo Grade to the Old Town district of Camarillo was dedicated as the Adolfo Camarillo Memorial Highway to honor the city's namesake and extends through the boundaries of the original Camarillo family ranch. In 2003, the portion of US 101 in Ventura County was named Screaming Eagles Highway in honor of the US Army 101st Airborne Division. Urban portions of the route in the Bay Area are called the James Lick Freeway, Bayshore Freeway, and Central Freeway. A portion of the route between Cochrane Road in Morgan Hill and SR 85 in San Jose is named the Sig Sanchez Freeway. The section of highway between SR 85 in Mountain View and Embarcadero Road in Palo Alto is officially known as the Frederick E. Terman Highway. Street routings in San Francisco are more commonly referred to by their street names rather than the route number. Portions of the route between Southern California and the Bay Area are named El Camino Real or El Camino Real Freeway, but such names are rarely used colloquially; the route number is used instead. In Northern California the section of US 101 between Sonoma and Marin counties is often referred to as the Novato Narrows because of the reduction from six lanes to four.

## Major intersections

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage. R reflects a realignment in the route since then, M indicates a second realignment, L refers to an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see California postmile § Official postmile definitions). Segments that remain unconstructed or have been relinquished to local control may be omitted. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.
| County | Location | Postmile | Exit | Destinations | Notes |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | — | I-5 south (Santa Ana Freeway south) – Santa Ana | No access to I-5 north; southern terminus of US 101; southern end of East Los Angeles Interchange |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | — | Euclid Avenue | Southbound exit and northbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | — | SR 60 east (Pomona Freeway) / Soto Street – Pomona | Southbound exit and northbound entrance; northern end of East Los Angeles Interchange proper; SR 60 west exit 1C |
| Los Angeles LA S0.00-38.19 | Los Angeles | S0.00 | 1A | Seventh Street | Southbound exit and northbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | | Whittier Boulevard | Northbound entrance only |
| Los Angeles LA S0.00-38.19 | Los Angeles | S0.62 | 1A | Fourth Street | No northbound entrance; signed as exit 1B southbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | S0.91 | 1B | First Street | No southbound entrance; signed as exit 1C southbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | 1C | Cesar Chavez Avenue | Northbound exit only; was formerly Brooklyn Avenue |
| Los Angeles LA S0.00-38.19 | Los Angeles | S1.330.00 | 1D | I-10 east (San Bernardino Freeway) – San Bernardino | No southbound entrance, was demolished in 1996 due to seismic issues;; San Bernardino Split portion of the East Los Angeles Interchange; access to I-10 east via the San Bernardino Freeway spur; no access to I-10 west; left exit southbound; I-10 west exit 19B; former western terminus of US 60 / US 70; former US 99 south; former I-110 east (1958–1965) |
| Los Angeles LA S0.00-38.19 | Los Angeles | 0.10 | 1E | Mission Road | No northbound exit |
| Los Angeles LA S0.00-38.19 | Los Angeles | 0.62 | 2A | Vignes Street | Northbound exit and entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 0.62– 0.82 | 2A-B | Alameda Street – Union Station | Signed as exit 2A southbound, 2B northbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 0.82 | 2B | Los Angeles Street | No northbound exit |
| Los Angeles LA S0.00-38.19 | Los Angeles | 1.10 | 2C | Spring Street | Northbound exit only |
| Los Angeles LA S0.00-38.19 | Los Angeles | 1.10 | 2C | Broadway | Southbound exit and northbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 1.40 | 3A | Temple Street | Southbound exit and entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 1.57 | 3B | SR 110 (Arroyo Seco Parkway north, Harbor Freeway south) to I-110 south / Grand Avenue – Pasadena, San Pedro | Northern end of Santa Ana Freeway; southern end of Hollywood Freeway access to I-110 south via SR 110 south; Four Level Interchange; Grand Avenue not signed southbound; signed as exit 3 northbound; SR 110 exit 24A |
| Los Angeles LA S0.00-38.19 | Los Angeles | 2.48 | 4A | Glendale Boulevard, Echo Park Avenue, Union Avenue | Union Avenue not signed northbound; Echo Park Avenue not signed southbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 2.86 | 4B | SR 2 east (Alvarado Street) | Southern end of SR 2 overlap |
| Los Angeles LA S0.00-38.19 | Los Angeles | 3.34 | 5A | Rampart Boulevard, Benton Way | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 3.76 | 5B | Silver Lake Boulevard | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 4.40 | 6A | Vermont Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 4.85 | 6B | Melrose Avenue, Normandie Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 5.55 | 7 | SR 2 west (Santa Monica Boulevard) / Western Avenue | Northern end of SR 2 overlap |
| Los Angeles LA S0.00-38.19 | Los Angeles | 6.25 | 8A | Sunset Boulevard | No northbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 6.52 | 8B | Hollywood Boulevard | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 6.91 | 8C | Gower Street | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 7.06 | 9A | Vine Street | Southbound exit only |
| Los Angeles LA S0.00-38.19 | Los Angeles | 7.46 | 9B | Cahuenga Boulevard – Hollywood Bowl | Signed as exit 9A northbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 7.84 | 9C | Highland Avenue – Hollywood Bowl | Former SR 170 south; signed as exit 9B northbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 8.84 | Cahuenga Pass, elevation 745 feet (227 m) | Cahuenga Pass, elevation 745 feet (227 m) | Cahuenga Pass, elevation 745 feet (227 m) |
| Los Angeles LA S0.00-38.19 | Los Angeles | 9.22 | 11A | Barham Boulevard – Burbank | No southbound exit, which was permanently closed on October 17, 2015, due to weaving concerns with the construction of the new Universal Studios Boulevard southbound onramp. |
| Los Angeles LA S0.00-38.19 | Los Angeles | 9.60 | 11B | Universal Studios Boulevard | No southbound exit; serves Universal Studios Hollywood |
| Los Angeles LA S0.00-38.19 | Los Angeles | 10.34 | 12A | Lankershim Boulevard – Universal City | Serves Universal Studios Hollywood |
| Los Angeles LA S0.00-38.19 | Los Angeles | 10.56 | 12B | Ventura Boulevard | No southbound exit |
| Los Angeles LA S0.00-38.19 | Los Angeles | 11.11 | 12C | Vineland Avenue to SR 134 east – Pasadena | Signed as exit 12B southbound; "to SR 134" not signed southbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | ​ | | Moorpark Street | Northbound entrance only |
| Los Angeles LA S0.00-38.19 | Los Angeles | 11.80 | 13 | SR 170 north (Hollywood Freeway north) – Sacramento | Northbound left exit and southbound left entrance; southbound access is via exit 13A; US 101 north transitions onto Ventura Freeway west; southern end of Hollywood Split; SR 170 south exit 5A |
| Los Angeles LA S0.00-38.19 | Los Angeles | 11.65 | 13B | SR 134 east (Ventura Freeway east) – Pasadena | Southbound exit and northbound entrance; northbound access is via exit 12C; US 101 south transitions onto Hollywood Freeway south; northern end of Hollywood Split; SR 134 west exit 1A |
| Los Angeles LA S0.00-38.19 | Los Angeles | 11.83 | 13A | Tujunga Avenue to SR 170 north | Southbound exit and northbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 12.85 | 14 | Laurel Canyon Boulevard – Studio City | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 13.88 | 15 | Coldwater Canyon Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 14.89 | 16 | Woodman Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 15.91 | 17 | Van Nuys Boulevard | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 16.94 | 18 | Sepulveda Boulevard | Northbound exit and southbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 17.17 | 19A | I-405 (San Diego Freeway) – Santa Monica, Sacramento | I-405 exit 63B |
| Los Angeles LA S0.00-38.19 | Los Angeles | 17.50 | 19B | Haskell Avenue | No southbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 18.61 | 20 | Hayvenhurst Avenue | Northbound exit and southbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 19.22 | 21 | Balboa Boulevard – Encino | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 20.23 | 22 | White Oak Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 21.25 | 23 | Reseda Boulevard | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 22.25 | 24 | Tampa Avenue | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 23.26 | 25 | Winnetka Avenue – Woodland Hills | |
| Los Angeles LA S0.00-38.19 | Los Angeles | 24.31 | 26A | De Soto Avenue, Serrania Avenue | Signed as exit 26 southbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 24.85 | 26B | Canoga Avenue | Northbound exit and southbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 25.34 | 27 | SR 27 (Topanga Canyon Boulevard) / Ventura Boulevard | Signed as exits 27A (north) and 27B (south) northbound |
| Los Angeles LA S0.00-38.19 | Los Angeles | 25.76 | 27C | Shoup Avenue | Northbound exit and southbound entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 26.45 | 28 | Fallbrook Avenue | Southbound exit only |
| Los Angeles LA S0.00-38.19 | Los Angeles | 26.86 | 28 | Woodlake Avenue | Northbound exit and entrance |
| Los Angeles LA S0.00-38.19 | Los Angeles | 27.36 | 29 | Mulholland Drive, Valley Circle Boulevard | |
| Los Angeles LA S0.00-38.19 | Calabasas | 28.29 | 30 | Parkway Calabasas | |
| Los Angeles LA S0.00-38.19 | Calabasas | 31.06 | 32 | Las Virgenes Road (CR N1) – Malibu Canyon | |
| Los Angeles LA S0.00-38.19 | Calabasas | 31.92 | 33 | Lost Hills Road | |
| Los Angeles LA S0.00-38.19 | Agoura Hills | 32.79 | 34 | Liberty Canyon Road | |
| Los Angeles LA S0.00-38.19 | Agoura Hills | ​ | Wallis Annenberg Wildlife Crossing (planned to open in 2024) | Wallis Annenberg Wildlife Crossing (planned to open in 2024) | Wallis Annenberg Wildlife Crossing (planned to open in 2024) |
| Los Angeles LA S0.00-38.19 | Agoura Hills | 33.69 | 35 | Chesebro Road | |
| Los Angeles LA S0.00-38.19 | Agoura Hills | 35.04 | 36 | Kanan Road (CR N9) | |
| Los Angeles LA S0.00-38.19 | Agoura Hills | 36.18 | 38 | Reyes Adobe Road | |
| Los Angeles LA S0.00-38.19 | Westlake Village | 37.54 | 39 | Lindero Canyon Road | |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 0.70 | 40 | SR 23 south (Westlake Boulevard) | Southern end of SR 23 overlap |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 1.62 | 41 | Hampshire Road | |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 3.02 | 43A | Rancho Road | Signed as exit 43B northbound |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 3.11 | 43B | SR 23 north (Moorpark Freeway) – Fillmore, Simi Valley | Northern end of SR 23 overlap; signed as exit 43A northbound; SR 23 south exits 12A-B; Simi Valley not signed southbound |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 4.06 | 44 | Moorpark Road | |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 5.05 | 45 | Lynn Road | |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 6.19 | 46 | Ventu Park Road – Newbury Park | |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 7.02 | 47A | Rancho Conejo Boulevard, Borchard Road | Signed as exits 47A (Rancho Conejo Boulevard) and 47B (Borchard Road) northbound |
| Ventura VEN 0.00-R43.62 | Thousand Oaks | 7.89 | 47B | Wendy Drive – Newbury Park | Signed as exit 47C northbound |
| Ventura VEN 0.00-R43.62 | Camarillo | 10.74 | 50 | Camarillo Springs Road – Camarillo Grove County Park | |
| Ventura VEN 0.00-R43.62 | Camarillo | 12.30 | 52 | Santa Rosa Road, Pleasant Valley Road | |
| Ventura VEN 0.00-R43.62 | Camarillo | 13.75 | 53A | Flynn Road | Northbound signage |
| Ventura VEN 0.00-R43.62 | Camarillo | 13.75 | 53A | Dawson Drive | Southbound signage |
| Ventura VEN 0.00-R43.62 | Camarillo | 13.85 | 53B | SR 34 (Lewis Road) | |
| Ventura VEN 0.00-R43.62 | Camarillo | 14.80 | 54 | Carmen Drive | |
| Ventura VEN 0.00-R43.62 | Camarillo | 15.89 | 55 | Las Posas Road | |
| Ventura VEN 0.00-R43.62 | Camarillo | 16.79 | 56 | Springville Drive | |
| Ventura VEN 0.00-R43.62 | Camarillo | 17.75 | 57 | Central Avenue | |
| Ventura VEN 0.00-R43.62 | Oxnard | 19.17 | 59 | Del Norte Boulevard | |
| Ventura VEN 0.00-R43.62 | Oxnard | 20.08 | 60 | SR 1 south (Rice Avenue) / Santa Clara Avenue | Southern end of SR 1 overlap |
| Ventura VEN 0.00-R43.62 | Oxnard | 21.01 | 61 | Rose Avenue | |
| Ventura VEN 0.00-R43.62 | Oxnard | 22.01 | 62A | SR 232 (Vineyard Avenue) – Oxnard | |
| Ventura VEN 0.00-R43.62 | Oxnard | 22.73 | 62B | Oxnard Boulevard | Former SR 1 south |
| Ventura VEN 0.00-R43.62 | Oxnard | ​ | 63A | Ventura Road | Southbound exit only |
| Ventura VEN 0.00-R43.62 | Ventura | R23.45 | 63B | Johnson Drive | Signed as exit 63 northbound |
| Ventura VEN 0.00-R43.62 | Ventura | R24.65 | 64 | Victoria Avenue – Channel Islands Harbor | |
| Ventura VEN 0.00-R43.62 | Ventura | 25.97 | 65 | Telephone Road | Northbound entrance is via Main Street |
| Ventura VEN 0.00-R43.62 | Ventura | 26.39 | 66A | SR 126 east (Santa Paula Freeway) – Santa Clarita | Signed as exit 66 southbound; southbound entrance is via exit 1C from SR 126 west; SR 126 west exit 1A |
| Ventura VEN 0.00-R43.62 | Ventura | 26.72 | 66B | Main Street (US 101 Bus. north) | No southbound exit |
| Ventura VEN 0.00-R43.62 | Ventura | 28.45 | 68 | Seaward Avenue | |
| Ventura VEN 0.00-R43.62 | Ventura | 29.45 | 69 | Vista del Mar Drive, Sanjon Road | Northbound exit and southbound entrance |
| Ventura VEN 0.00-R43.62 | Ventura | 30.15 | 70A | California Street, Ventura Avenue | |
| Ventura VEN 0.00-R43.62 | Ventura | 30.91 | 70B | SR 33 north (Ojai Freeway) – Ojai | |
| Ventura VEN 0.00-R43.62 | Ventura | 31.50 | 71 | Main Street (US 101 Bus. south) | Southbound exit and northbound entrance |
| Ventura VEN 0.00-R43.62 | ​ | R32.70 | 72 | SR 1 north (PCH) – State Beaches | Northern end of SR 1 overlap; northbound exit and southbound entrance |
| Ventura VEN 0.00-R43.62 | ​ | R38.98 | 78 | SR 1 south (PCH) – Seacliff | Southern end of SR 1 overlap |
| Ventura VEN 0.00-R43.62 | ​ | R39.80 | 79 | Mussel Shoals (Old Pacific Coast Highway) | Southbound exit and entrance |
| Ventura VEN 0.00-R43.62 | ​ | 41.00 | 81 | La Conchita (West Surfside Street) | Northbound exit and entrance |
| Ventura VEN 0.00-R43.62 | ​ | R43.57 | 83 | Bates Road | |
| Ventura–Santa Barbara county line | ​ | ​ | Northwestern end of Ventura Freeway | Northwestern end of Ventura Freeway | Northwestern end of Ventura Freeway |
| Santa Barbara SB R0.00-90.99 | Carpinteria | R0.63 | 84 | SR 150 east – Ojai, Lake Casitas | |
| Santa Barbara SB R0.00-90.99 | Carpinteria | 1.61 | 85 | Bailard Avenue | |
| Santa Barbara SB R0.00-90.99 | Carpinteria | 2.64 | 86A | Casitas Pass Road | Signed as exit 86 northbound; former SR 224 |
| Santa Barbara SB R0.00-90.99 | Carpinteria | 3.06 | 86B | Linden Avenue | Southbound exit and northbound entrance |
| Santa Barbara SB R0.00-90.99 | Carpinteria | 3.77 | 87A | Reynolds Avenue, Santa Monica Road | Signed as exit 87 northbound |
| Santa Barbara SB R0.00-90.99 | Carpinteria | 4.34 | 87B | Carpinteria Avenue | Southbound exit only |
| Santa Barbara SB R0.00-90.99 | Toro Canyon | R5.28 | 88 | Padaro Lane, Santa Claus Lane | |
| Santa Barbara SB R0.00-90.99 | Summerland | R7.14 | 90 | Padaro Lane – Summerland | |
| Santa Barbara SB R0.00-90.99 | Summerland | R8.26 | 91 | Evans Avenue – Summerland | |
| Santa Barbara SB R0.00-90.99 | Montecito | 9.00 | 92 | Sheffield Drive | |
| Santa Barbara SB R0.00-90.99 | Montecito | 10.02 | 93 | San Ysidro Road | |
| Santa Barbara SB R0.00-90.99 | Montecito | 10.54 | 94A | Olive Mill Road, Coast Village Road | No northbound entrance |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 11.10 | 94B | Hermosillo Road | Northbound exit only |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 11.41 | 94C | Cabrillo Boulevard, Coast Village Road | No southbound entrance; signed as exit 94B southbound |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | ​ | 95 | Los Patos Way (unsigned) | Southbound exit only |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 12.10 | 95 | Salinas Street | Northbound exit and entrance |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 12.75 | 96 | Milpas Street | Former SR 144; northbound exit signed as exit 96A; southbound as exits 96B and 96A |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 13.49 | 96 | Laguna Street, Garden Street – Downtown Santa Barbara | Laguna Street/Garden Street northbound exit signed as exit 96B; Garden Street southbound exit signed as exit 96C |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | R14.19 | 97 | Bath Street, Castillo Street; Santa Barbara Harbor | |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | R14.76 | 98A | Carrillo Street – Downtown Santa Barbara | Signed as exit 98 southbound |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 15.26 | 98B | Arrellaga Street | Northbound exit and entrance |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | R15.73 | 99A | Mission Street | Signed as exit 99 southbound |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 16.05 | 99B | Pueblo Street | Northbound exit only |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 16.55 | 100 | Las Positas Road | Former SR 225 |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 17.78 | 101A | La Cumbre Road, Hope Avenue | |
| Santa Barbara SB R0.00-90.99 | Santa Barbara | 18.38 | 101B | SR 154 west / State Street – Cachuma Lake | |
| Santa Barbara SB R0.00-90.99 | Eastern Goleta Valley | 18.92 | 102 | El Sueno Road | Northbound exit and entrance |
| Santa Barbara SB R0.00-90.99 | Eastern Goleta Valley | 20.06 | 103 | Turnpike Road | |
| Santa Barbara SB R0.00-90.99 | Goleta | 21.15 | 104A | Patterson Avenue | Signed as exit 104 southbound |
| Santa Barbara SB R0.00-90.99 | Goleta | 21.41 | 104B | SR 217 west – Airport, UCSB | Northbound exit and southbound entrance |
| Santa Barbara SB R0.00-90.99 | Goleta | 22.53 | 105 | Fairview Avenue | |
| Santa Barbara SB R0.00-90.99 | Goleta | 23.72 | 107 | Los Carneros Road | |
| Santa Barbara SB R0.00-90.99 | Goleta | 24.77 | 108 | Glen Annie Road, Storke Road | |
| Santa Barbara SB R0.00-90.99 | Goleta | 26.91 | 110 | Winchester Canyon Road, Hollister Avenue | All ramps are via Cathedral Oaks Road |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | 30.06 | 113 | Dos Pueblos Canyon Road | |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | 32.84 | 116 | El Capitan Ranch Road | |
| Santa Barbara SB R0.00-90.99 | ​ | 33.85 | 117 | El Capitan State Beach | |
| Santa Barbara SB R0.00-90.99 | ​ | 36.62 | 120 | Refugio Road – Refugio State Beach | |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | Gaviota | 44.82 | 128 | Mariposa Reina | Interchange |
| Santa Barbara SB R0.00-90.99 | Gaviota | ​ | | Gaviota State Beach (Gaviota Beach Road) | At-grade intersection |
| Santa Barbara SB R0.00-90.99 | Gaviota Pass | 46.30– 46.90 | Gaviota Rest Area | Gaviota Rest Area | Gaviota Rest Area |
| Santa Barbara SB R0.00-90.99 | Gaviota Pass | 47.19 | Gaviota Gorge Tunnel (northbound only) | Gaviota Gorge Tunnel (northbound only) | Gaviota Gorge Tunnel (northbound only) |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | Las Cruces | R48.85 | 132 | SR 1 north – Lompoc, Vandenberg SFB | Northern end of SR 1 overlap |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | Buellton | R56.46 | 139 | Santa Rosa Road | |
| Santa Barbara SB R0.00-90.99 | Buellton | R57.12 | 140A | SR 246 – Lompoc, Solvang | |
| Santa Barbara SB R0.00-90.99 | Buellton | R57.55 | 140B | McMurray Road, Avenue of the Flags | |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | 62.67 | 146 | SR 154 east / Zaca Station Road – Los Olivos, Cachuma Lake | |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | Los Alamos | 70.92 | 154 | SR 135 north – Los Alamos, Vandenberg SFB | |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Barbara SB R0.00-90.99 | ​ | 78.69 | 161 | Solomon Summit Undercrossing | |
| Santa Barbara SB R0.00-90.99 | Orcutt | 82.18 | 164 | Clark Avenue – Orcutt | |
| Santa Barbara SB R0.00-90.99 | Orcutt | 83.42 | 166 | Union Valley Parkway | |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 84.36 | 167 | Santa Maria Way (US 101 Bus. north) | |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 86.59 | 169 | Betteravia Road – Sisquoc | |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 87.60 | 170 | Stowell Road | |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 88.60 | 171 | SR 166 west (Main Street) – Santa Maria, Guadalupe | Southern end of SR 166 overlap |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 89.69 | 172 | Donovan Road | |
| Santa Barbara SB R0.00-90.99 | Santa Maria | 90.75 | 173 | SR 135 south (Broadway, US 101 Bus. south) – Santa Maria | |
| San Luis Obispo SLO 0.00-R69.32 | ​ | 0.81 | 175 | SR 166 east – Maricopa, Bakersfield | Northern end of SR 166 overlap |
| San Luis Obispo SLO 0.00-R69.32 | Nipomo | 4.85 | 179 | Tefft Street – Nipomo | |
| San Luis Obispo SLO 0.00-R69.32 | Nipomo | 6.43 | 180 | Willow Road | |
| San Luis Obispo SLO 0.00-R69.32 | Nipomo | 7.84 | 182 | Thompson Road, Los Berros Road | |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | Arroyo Grande | 12.52 | 186 | Traffic Way (US 101 Bus. north), Fair Oaks Avenue | No northbound entrance |
| San Luis Obispo SLO 0.00-R69.32 | Arroyo Grande | 13.17 | 187A | SR 227 north (Grand Avenue, US 101 Bus. south) | |
| San Luis Obispo SLO 0.00-R69.32 | Arroyo Grande | 13.75 | 187B | Brisco Road, Halcyon Drive | |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 14.61 | 188 | Oak Park Road | |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 15.58– 15.88 | 189 | 4th Street, Five Cities Drive | Signed as exits 189 (4th Street) and 190A (Five Cities Drive) southbound |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 16.62 | 190 | Price Street (US 101 Bus. north) | No northbound entrance; northbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 16.62 | 190B | Hinds Avenue, Price Canyon Road | No northbound entrance; southbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 16.89 | 191A | Wadsworth Avenue | Northbound signage; northbound entrance via Bello Street, southbound entrance via Price Street |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 16.89 | 191A | SR 1 south – Pismo Beach | Southbound signage; north and south entrances via Price Street |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 17.76 | 191B | Shell Beach Road | Northbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | 17.76 | 191B | Price Street (SR 1 south, US 101 Bus. south) | Southern end of SR 1 overlap; southbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | R19.81 | 193 | Spyglass Drive | Northbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Pismo Beach | R19.81 | 193 | Shell Beach Road | Southbound signage |
| San Luis Obispo SLO 0.00-R69.32 | Avila Beach | R21.11 | 195 | Avila Beach Drive | |
| San Luis Obispo SLO 0.00-R69.32 | Avila Beach | R22.29 | 196 | San Luis Bay Drive – See Canyon, Avila Beach | |
| San Luis Obispo SLO 0.00-R69.32 | ​ | R24.30 | 198 | Higuera Street | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 25.91 | 200A | Los Osos Valley Road | Signed as exit 200 southbound |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 26.83 | 200B | Prado Road, Elks Lane | Northbound exit and entrance |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 27.50 | 201 | SR 227 south (Madonna Road) | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 28.07 | 202A | Marsh Street | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 28.81 | 202B | Broad Street | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 29.08 | 203A | Osos Street, Santa Rosa Street | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 29.08 | 203B | SR 1 north – Morro Bay, Hearst Castle | Northern end of SR 1 overlap |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 29.40 | 203C | California Boulevard | |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 29.77 | 203D | Grand Avenue – Cal Poly | Northbound exit and southbound entrance |
| San Luis Obispo SLO 0.00-R69.32 | San Luis Obispo | 29.99 | 204 | Monterey Street | No southbound entrance |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | ​ | 35.00 | Cuesta Pass, elevation 1,522 feet (464 m) | Cuesta Pass, elevation 1,522 feet (464 m) | Cuesta Pass, elevation 1,522 feet (464 m) |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | ​ | 37.85 | 211 | SR 58 east – Santa Margarita | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 42.27 | 216A | Santa Barbara Road | Signed as exit 216 southbound |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 42.90 | 216B | San Diego Way | Northbound exit and southbound entrance |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 44.01 | 218A | Santa Rosa Road | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 44.84 | 218B | Curbaril Avenue | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 45.57 | 219 | SR 41 (Morro Road) | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 45.96 | 220A | Traffic Way (US 101 Bus. north) | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 46.87 | 220B | San Anselmo Road | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 48.33 | 222 | Del Rio Road (US 101 Bus. south) | |
| San Luis Obispo SLO 0.00-R69.32 | Atascadero | 49.32 | 223 | San Ramon Road, Santa Cruz Road | |
| San Luis Obispo SLO 0.00-R69.32 | Templeton | 50.64 | 224 | Vineyard Drive (US 101 Bus. north) | |
| San Luis Obispo SLO 0.00-R69.32 | Templeton | 51.45 | 225 | Las Tablas Road | |
| San Luis Obispo SLO 0.00-R69.32 | Templeton | 52.44 | 226 | Main Street (US 101 Bus. south) | |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 53.89 | 228 | SR 46 west – Cambria, Hearst Castle | Southern end of SR 46 overlap |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 55.67 | 229 | Spring Street (US 101 Bus. north) | Northbound exit and southbound entrance; former US 101 |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 56.14 | 230 | Pine Street | Southbound exit and entrance |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | ​ | 230 | Paso Robles Street | Northbound exit and entrance |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 56.88 | 231A | 17th Street | Southbound exit and entrance |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 57.92 | 231B | SR 46 east (24th Street / CR G14 west) – Fresno, Bakersfield | Northern end of SR 46 overlap; signed as exit 231 northbound |
| San Luis Obispo SLO 0.00-R69.32 | Paso Robles | 58.76 | 232 | Spring Street (US 101 Bus. south) | No southbound entrance; former US 101 |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| San Luis Obispo SLO 0.00-R69.32 | San Miguel | 65.08 | 239A | Mission Street – San Miguel | Northbound exit and southbound left entrance |
| San Luis Obispo SLO 0.00-R69.32 | San Miguel | 65.56 | 239B | 10th Street | Signed as exit 239 southbound |
| San Luis Obispo SLO 0.00-R69.32 | San Miguel | 67.23 | 241A | Mission Street – San Miguel | Southbound exit and northbound entrance |
| San Luis Obispo SLO 0.00-R69.32 | ​ | R67.71 | 241B | South Camp Roberts (Frontage Road) | Signed as exit 241 northbound; served the former south entrance to Camp Roberts |
| Monterey MON R0.00-101.32 | ​ | R0.84 | 244 | Camp Roberts (main gate) | |
| Monterey MON R0.00-101.32 | ​ | R2.15 | 245 | East Garrison (Bradley Road) | |
| Monterey MON R0.00-101.32 | ​ | R3.35– R5.10 | Camp Roberts Rest Area | Camp Roberts Rest Area | Camp Roberts Rest Area |
| Monterey MON R0.00-101.32 | Bradley | R7.94 | 251 | Bradley (Bradley Road) | |
| Monterey MON R0.00-101.32 | ​ | R9.67 | 252 | CR G18 (Jolon Road) – Fort Hunter Liggett | |
| Monterey MON R0.00-101.32 | ​ | R15.47 | 258 | Alvarado Road | |
| Monterey MON R0.00-101.32 | ​ | R17.86 | 260 | Los Lobos Road | |
| Monterey MON R0.00-101.32 | ​ | R21.99 | 263 | Paris Valley Road – San Ardo | |
| Monterey MON R0.00-101.32 | ​ | R29.90 | 271 | Paris Valley Road – Lockwood | |
| Monterey MON R0.00-101.32 | San Lucas | R32.02 | 273 | SR 198 east – San Lucas, Coalinga | |
| Monterey MON R0.00-101.32 | ​ | R37.31 | 278 | Wild Horse Road | |
| Monterey MON R0.00-101.32 | King City | R39.77 | 281 | First Street (US 101 Bus. north / CR G15 to CR G13) | |
| Monterey MON R0.00-101.32 | King City | R40.72 | 282A | Canal Street | |
| Monterey MON R0.00-101.32 | King City | R41.18 | 282B | Broadway (US 101 Bus. south / CR G13) | |
| Monterey MON R0.00-101.32 | ​ | R41.95 | 283 | CR G14 (Jolon Road) – Fort Hunter Liggett | |
| Monterey MON R0.00-101.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Monterey MON R0.00-101.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Monterey MON R0.00-101.32 | Greenfield | 52.66 | 293 | Espinosa Road (US 101 Bus. north, CR G16) | Former US 101 |
| Monterey MON R0.00-101.32 | Greenfield | 53.36 | 294A | Oak Avenue | |
| Monterey MON R0.00-101.32 | Greenfield | 53.86 | 294B | Walnut Avenue | |
| Monterey MON R0.00-101.32 | Greenfield | 54.79 | 295 | Thorne Road (US 101 Bus. south) | Former US 101 |
| Monterey MON R0.00-101.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Monterey MON R0.00-101.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Monterey MON R0.00-101.32 | Soledad | 60.40 | 301 | Arroyo Seco Road | |
| Monterey MON R0.00-101.32 | Soledad | 61.59 | 302 | SR 146 (US 101 Bus. north) – Soledad | Former US 101 |
| Monterey MON R0.00-101.32 | Soledad | 62.70 | 303 | Front Street (US 101 Bus. south) | |
| Monterey MON R0.00-101.32 | ​ | 64.63 | 305 | Camphora Gloria Road | |
| Monterey MON R0.00-101.32 | ​ | 66.40 | 307 | Salinas Valley State Prison | |
| Monterey MON R0.00-101.32 | Gonzales | 69.37 | 310 | Gloria Road (US 101 Bus. north), Alta Street | Former US 101 |
| Monterey MON R0.00-101.32 | Gonzales | 70.86 | 311 | 5th Street | |
| Monterey MON R0.00-101.32 | Gonzales | 72.61 | 313 | Old Stage Road (US 101 Bus. south) | |
| Monterey MON R0.00-101.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Monterey MON R0.00-101.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Monterey MON R0.00-101.32 | Chualar | 76.97 | 317 | Chualar (Main Street) | |
| Monterey MON R0.00-101.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Monterey MON R0.00-101.32 | ​ | 82.47 | 323 | Abbott Street (US 101 Bus. north) – Spreckels | Northbound left exit and southbound left entrance; interchange |
| Monterey MON R0.00-101.32 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Monterey MON R0.00-101.32 | Salinas | 85.62 | 326A | Airport Boulevard | |
| Monterey MON R0.00-101.32 | Salinas | ​ | 326B | Fairview Avenue | Northbound exit only |
| Monterey MON R0.00-101.32 | Salinas | 86.12 | 326C | Monterey Peninsula (South Sanborn Road) | Signed as exit 326B southbound |
| Monterey MON R0.00-101.32 | Salinas | 86.82 | 327 | SR 68 (John Street) | |
| Monterey MON R0.00-101.32 | Salinas | 87.30 | 328 | Market Street to SR 183 – Santa Cruz | |
| Monterey MON R0.00-101.32 | Salinas | R88.24 | 329 | Main Street (SR 183, US 101 Bus. south) | |
| Monterey MON R0.00-101.32 | Salinas | R89.27 | 330 | Laurel Drive | |
| Monterey MON R0.00-101.32 | Salinas | R91.01 | 331 | Boronda Road (US 101 Bus. south) | |
| Monterey MON R0.00-101.32 | ​ | 92.19 | 333 | Sala Road | |
| Monterey MON R0.00-101.32 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Monterey MON R0.00-101.32 | Prunedale | 95.44 | 336 | SR 156 west / Vierra Canyon Road – Monterey Peninsula | Southern end of SR 156 overlap; interchange |
| Monterey MON R0.00-101.32 | Prunedale | 96.14 | 337 | San Miguel Canyon Road (CR G12) | Interchange |
| Monterey MON R0.00-101.32 | Prunedale | 98.37 | 339 | Crazy Horse Canyon Road, Echo Valley Road | Interchange |
| Monterey MON R0.00-101.32 | Prunedale | 100.39 | | Dunbarton Road to San Juan Road (CR G11) | Closed in 2015 after the construction of the San Juan Road interchange |
| San Benito SBT 0.00-R7.52 | ​ | 0.13 | 342 | San Juan Road (CR G11) – Aromas, Watsonville | Interchange |
| San Benito SBT 0.00-R7.52 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| San Benito SBT 0.00-R7.52 | ​ | 3.01 | 345 | SR 156 east – San Juan Bautista, Hollister | Northern end of SR 156 overlap |
| San Benito SBT 0.00-R7.52 | ​ | R4.90 | 347 | SR 129 west – Watsonville, Santa Cruz | |
| San Benito SBT 0.00-R7.52 | ​ | R6.49 | 349 | Betabel Road, Y Road | |
| San Benito SBT 0.00-R7.52 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Santa Clara SCL R0.03-52.55 | ​ | 3.16 | 353 | SR 25 south – Hollister, Pinnacles National Park | Interchange |
| Santa Clara SCL R0.03-52.55 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Santa Clara SCL R0.03-52.55 | Gilroy | R4.94 | 355 | Monterey Road (US 101 Bus. north) | |
| Santa Clara SCL R0.03-52.55 | Gilroy | R6.08 | 356 | SR 152 east (Pacheco Pass Road) / 10th Street | Southern end of SR 152 overlap |
| Santa Clara SCL R0.03-52.55 | Gilroy | R7.53 | 357 | SR 152 west (Leavesley Road / CR G9) – Gilroy | Northern end of SR 152 overlap |
| Santa Clara SCL R0.03-52.55 | ​ | R10.27 | 360 | Masten Avenue | |
| Santa Clara SCL R0.03-52.55 | San Martin | R12.46 | 362 | San Martin Avenue | |
| Santa Clara SCL R0.03-52.55 | Morgan Hill | R15.07 | 365 | Tennant Avenue | |
| Santa Clara SCL R0.03-52.55 | Morgan Hill | R16.01 | 366 | East Dunne Avenue | |
| Santa Clara SCL R0.03-52.55 | Morgan Hill | R17.82 | 367 | Cochrane Road (US 101 Bus. south) | |
| Santa Clara SCL R0.03-52.55 | San Jose | R21.25 | 371 | Coyote Creek Golf Drive | |
| Santa Clara SCL R0.03-52.55 | San Jose | R23.10 | 373 | Bailey Avenue | |
| Santa Clara SCL R0.03-52.55 | San Jose | R26.78 | 377A | SR 85 north (West Valley Freeway) – Mountain View, Cupertino | No northbound entrance; signed as exit 377B southbound; SR 85 south exit 1A |
| Santa Clara SCL R0.03-52.55 | San Jose | ​ | ♦ | SR 85 north | HOV access only; northbound exit and southbound entrance |
| Santa Clara SCL R0.03-52.55 | San Jose | R27.00 | 377B | Silicon Valley Boulevard, Bernal Road | Signed as exit 377A southbound |
| Santa Clara SCL R0.03-52.55 | San Jose | R28.61 | 378 | Blossom Hill Road (CR G10) / Silver Creek Valley Road to SR 82 | Southern end of Bayshore Freeway; former SR 82 |
| Santa Clara SCL R0.03-52.55 | San Jose | 30.10 | 380 | Hellyer Avenue | |
| Santa Clara SCL R0.03-52.55 | San Jose | 31.00 | 381 | Yerba Buena Road | Southbound exit was separated from Exit 382 in 2014 |
| Santa Clara SCL R0.03-52.55 | San Jose | 31.70 | 382 | Capitol Expressway (CR G21) | |
| Santa Clara SCL R0.03-52.55 | San Jose | 33.03 | 383 | Tully Road | |
| Santa Clara SCL R0.03-52.55 | San Jose | 34.11 | 385B | I-280 north / I-680 north – Downtown San Jose, Sacramento | Northbound exit and southbound entrance; southern end of Joe Colla Interchange; ramps extend over the Story Road interchange; I-680 exit 1B |
| Santa Clara SCL R0.03-52.55 | San Jose | 34.55 | 385A | Story Road | Signed as exit 385 northbound |
| Santa Clara SCL R0.03-52.55 | San Jose | 34.87 | 384 | I-280 north / I-680 north – San Francisco, Downtown San Jose, Sacramento | Southbound exit and northbound entrance; northern end of Joe Colla Interchange; I-680 exit 1B |
| Santa Clara SCL R0.03-52.55 | San Jose | R35.76 | 386A | SR 130 (Alum Rock Avenue) / Santa Clara Street | |
| Santa Clara SCL R0.03-52.55 | San Jose | R36.14 | 386B | McKee Road, Julian Street | |
| Santa Clara SCL R0.03-52.55 | San Jose | ​ | 387 | Mabury Road, Taylor Street | Planned interchange |
| Santa Clara SCL R0.03-52.55 | San Jose | 37.73 | 388A | Oakland Road, 13th Street | Former SR 238 |
| Santa Clara SCL R0.03-52.55 | San Jose | 38.30 | 388B | I-880 north (Nimitz Freeway) – Oakland | I-880 exits 4B-C; former SR 17 |
| Santa Clara SCL R0.03-52.55 | San Jose | 38.30 | 388C | I-880 south (Nimitz Freeway) – Santa Cruz | I-880 exits 4B-C; former SR 17 |
| Santa Clara SCL R0.03-52.55 | San Jose | 38.80 | 389A | Old Bayshore Highway, 4th Street | No southbound exit |
| Santa Clara SCL R0.03-52.55 | San Jose | 39.29 | 389B | Brokaw Road, First Street | Signed as exit 389 southbound |
| Santa Clara SCL R0.03-52.55 | San Jose | 39.93 | 390 | SR 87 south (Guadalupe Parkway) | Southbound exit and northbound entrance; SR 87 north exit 9B |
| Santa Clara SCL R0.03-52.55 | San Jose–Santa Clara line | 40.70 | 391 | Trimble Road, De la Cruz Boulevard (CR G6) | |
| Santa Clara SCL R0.03-52.55 | Santa Clara | 41.98 | 392 | San Tomas Expressway, Montague Expressway (CR G4) | |
| Santa Clara SCL R0.03-52.55 | Santa Clara | 42.73 | 393 | Great America Parkway, Bowers Avenue | |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | 43.85 | 394 | Lawrence Expressway (CR G2) | |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | 44.83 | 395 | Fair Oaks Avenue | Signed as exits 395A (north) and 395B (south) southbound |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | 45.68 | 396A | Mathilda Avenue to SR 237 east | Former SR 85 |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | ​ | — | US 101 Express Lanes | Southern end of Express Lanes |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | 46.13 | 396B | SR 237 east – Milpitas | Southbound exit and northbound entrance; SR 237 west exit 3A |
| Santa Clara SCL R0.03-52.55 | Sunnyvale | 46.13 | 396C | SR 237 west – Mountain View | Northbound exit and southbound entrance; SR 237 east exit 3A |
| Santa Clara SCL R0.03-52.55 | Mountain View | 47.01 | 397 | Ellis Street | |
| Santa Clara SCL R0.03-52.55 | Mountain View | 47.89 | 398A | Moffett Boulevard, NASA Parkway | Signed as exit 398 northbound |
| Santa Clara SCL R0.03-52.55 | Mountain View | ​ | — | SR 85 Express Lanes south | Express Lanes access only; southbound exit and northbound entrance |
| Santa Clara SCL R0.03-52.55 | Mountain View | 48.10 | 398B | SR 85 south – Cupertino, Santa Cruz | Southbound exit and northbound entrance; northbound exit is via exit 396C; SR 85 north exit 24B |
| Santa Clara SCL R0.03-52.55 | Mountain View | 48.60 | 399A | Shoreline Boulevard | Signed as exit 399 southbound |
| Santa Clara SCL R0.03-52.55 | Mountain View | 48.97 | 399B | Old Middlefield Way | Northbound exit and southbound entrance |
| Santa Clara SCL R0.03-52.55 | Mountain View | 49.61 | 400A | Amphitheatre Parkway, Rengstorff Avenue | Signed as exits 400A (Amphitheatre Parkway) and 400B (Rengstorff Avenue) northbound |
| Santa Clara SCL R0.03-52.55 | Mountain View–Palo Alto line | 50.32 | 400C | San Antonio Road | Signed as exits 400B (north) and 400C (south) southbound |
| Santa Clara SCL R0.03-52.55 | Palo Alto | 52.01 | 402 | Oregon Expressway (CR G3) | |
| Santa Clara SCL R0.03-52.55 | Palo Alto | 52.17 | 402 | Embarcadero Road | |
| San Mateo SM 0.00-26.11 | East Palo Alto | 0.89 | 403 | University Avenue (to SR 109) | |
| San Mateo SM 0.00-26.11 | East Palo Alto–Menlo Park line | 1.87 | 404 | Willow Road (SR 114) | |
| San Mateo SM 0.00-26.11 | Menlo Park | 3.59 | 406 | SR 84 east (Marsh Road) – Dumbarton Bridge | Southern end of SR 84 overlap |
| San Mateo SM 0.00-26.11 | Redwood City | 5.39 | 408 | SR 84 west (Woodside Road) / Seaport Boulevard | Northern end of SR 84 overlap |
| San Mateo SM 0.00-26.11 | Redwood City | 6.62 | 409 | Whipple Avenue | |
| San Mateo SM 0.00-26.11 | San Carlos | ​ | 411 | Brittan Avenue | Southbound exit and entrance |
| San Mateo SM 0.00-26.11 | San Carlos | 8.40 | 411 | Holly Street, Redwood Shores Parkway | |
| San Mateo SM 0.00-26.11 | San Carlos | ​ | 412 | Harbor Boulevard | Southbound exit and entrance |
| San Mateo SM 0.00-26.11 | Belmont | 9.55 | 412 | Marine Parkway, Ralston Avenue | Former Legislative Route 214 |
| San Mateo SM 0.00-26.11 | San Mateo | 11.15 | 414A | Hillsdale Boulevard – Foster City | |
| San Mateo SM 0.00-26.11 | San Mateo | 11.90 | 414B | SR 92 – Hayward, San Mateo Bridge, Half Moon Bay | SR 92 exits 13A-B |
| San Mateo SM 0.00-26.11 | San Mateo | 11.90 | 414B | Fashion Island Boulevard | No northbound exit |
| San Mateo SM 0.00-26.11 | San Mateo | 12.69 | 415 | Kehoe Avenue | Northbound exit and entrance |
| San Mateo SM 0.00-26.11 | San Mateo | 13.46 | 416 | 3rd Avenue | Former SR 92 |
| San Mateo SM 0.00-26.11 | San Mateo | 14.33 | 417A | Dore Avenue | Northbound exit only |
| San Mateo SM 0.00-26.11 | San Mateo | 14.33 | 417 | Poplar Avenue | Southbound exit and entrance |
| San Mateo SM 0.00-26.11 | San Mateo | 14.69 | 417B | Peninsula Avenue – Burlingame | Northbound exit and entrance |
| San Mateo SM 0.00-26.11 | Burlingame | 16.02 | 419A | Anza Boulevard | Northbound exit and entrance |
| San Mateo SM 0.00-26.11 | Burlingame | 16.58 | 419B | Broadway | Signed as exit 419 southbound |
| San Mateo SM 0.00-26.11 | Millbrae | 17.95 | 421 | Millbrae Avenue | Signed as exit 420 southbound |
| San Mateo SM 0.00-26.11 | San Bruno | 19.12 | 422 | San Francisco International Airport | Southbound exit is part of exit 423A |
| San Mateo SM 0.00-26.11 | San Bruno | R20.39 | 423A | San Bruno Avenue | |
| San Mateo SM 0.00-26.11 | San Bruno | R20.72 | — | US 101 Express Lanes | Northern end of Express Lanes |
| San Mateo SM 0.00-26.11 | San Bruno | R20.72 | 423B | I-380 west to I-280 – San Bruno | I-380 west exit 6, east exits 6A-B |
| San Mateo SM 0.00-26.11 | South San Francisco | R20.72 | 423C | North Access Road (I-380 east) – North Cargo Area | Southbound exit is part of exit 423A |
| San Mateo SM 0.00-26.11 | South San Francisco | 21.69 | 424 | South Airport Boulevard | |
| San Mateo SM 0.00-26.11 | South San Francisco | 21.92 | 425A | Grand Avenue – Downtown South San Francisco | No southbound entrance |
| San Mateo SM 0.00-26.11 | South San Francisco | 22.71 | 425B | Oyster Point Boulevard | |
| San Mateo SM 0.00-26.11 | South San Francisco | ​ | 425C | South San Francisco (Airport Boulevard) | Southbound exit and entrance |
| San Mateo SM 0.00-26.11 | Brisbane | 23.39 | 426A | Brisbane, Cow Palace (Bayshore Boulevard) | Northbound exit only |
| San Mateo SM 0.00-26.11 | Brisbane | 23.66 | 426B | Sierra Point Parkway, Marina Boulevard | Signed as exit 426 southbound; southbound exit and entrance are located 1.2 miles (1.9 km) north of northbound exit and entrance |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 0.03 | 429A | Tunnel Avenue – Candlestick Park | |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 0.77 | 429B | Third Street – Cow Palace | |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 1.11 | 429C | Paul Avenue | No northbound entrance; signed as exit 430A southbound |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 1.44 | 430A | I-280 – Daly City, Downtown San Francisco | Northbound exit and southbound entrance; southern end of Alemany Maze; ramps extend over the Silver Avenue interchange; I-280 north exit 54A, south exit 54 |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 1.77 | 430B | Silver Avenue | No northbound entrance |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 1.98 | 431 | I-280 south – Daly City | Southbound exit and northbound entrance; northern end of Alemany Maze; I-280 north exit 54B |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 2.00 | 431 | Alemany Boulevard, Bayshore Boulevard | |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 2.92 | 432 | Cesar Chavez Street, Potrero Avenue | Cesar Chavez Street was formerly Army Street |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 4.10 | 433A | Vermont Street | Northbound exit only |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | R4.24 | 433B | I-80 east – Bay Bridge, Oakland | Northern end of Bayshore Freeway; southern end of Central Freeway; signed as exit 433 southbound; I-80 exits 1A-B |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | R4.55 | 433C | Ninth Street – Civic Center | Northbound exit and southbound entrance |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | T5.20 | 434A | Duboce Avenue | Northbound exit and southbound entrance |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 5.40 | 434B | Octavia Boulevard to Fell Street | Northbound exit and southbound entrance |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | Northern end of Central Freeway | Northern end of Central Freeway | Northern end of Central Freeway |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | | Market Street | No left turns |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | | Geary Boulevard | No left turn from northbound US 101 |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | | Broadway | No left turns from Broadway; no left turn from northbound US 101 |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | | Van Ness Avenue, Lombard Street | No left turn from southbound Van Ness Avenue; no left turn from westbound Lombard Street |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | Southern end of Presidio Parkway | Southern end of Presidio Parkway | Southern end of Presidio Parkway |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | L8.59 | 437 | Marina Boulevard, Girard Road – Marina, Presidio | |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 9.40 | 438 | SR 1 south (Park Presidio Boulevard) – Golden Gate Park | Southern end of SR 1 overlap |
| City and County of San Francisco SF 0.00-11.18 | City and County of San Francisco SF 0.00-11.18 | 9.71 | 439 | Lincoln Boulevard – View Area, Presidio, Golden Gate NRA, Fort Point | Northern end of Presidio Parkway; Lincoln Boulevard not signed northbound |
| Golden Gate | Golden Gate | 11.18– L0.01 | Golden Gate Bridge (Southbound toll only; no state maintenance on bridge) | Golden Gate Bridge (Southbound toll only; no state maintenance on bridge) | Golden Gate Bridge (Southbound toll only; no state maintenance on bridge) |
| Marin MRN L0.00-27.63 | Sausalito | 0.10 | H. Dana Bower Rest Area and Vista Point (northbound only); southern end of Redwood Highway | H. Dana Bower Rest Area and Vista Point (northbound only); southern end of Redwood Highway | H. Dana Bower Rest Area and Vista Point (northbound only); southern end of Redwood Highway |
| Marin MRN L0.00-27.63 | Sausalito | 0.32 | 442 | Alexander Avenue | |
| Marin MRN L0.00-27.63 | Sausalito | 0.89 | Robin Williams Tunnel under Waldo Grade | Robin Williams Tunnel under Waldo Grade | Robin Williams Tunnel under Waldo Grade |
| Marin MRN L0.00-27.63 | Sausalito | 1.52 | 443 | Spencer Avenue, Monte Mar Drive | |
| Marin MRN L0.00-27.63 | Sausalito | 2.48 | 444 | Rodeo Avenue (east) | Northbound exit and entrance only |
| Marin MRN L0.00-27.63 | Sausalito | 2.48 | 444 | Rodeo Avenue (west; not a thru road) | Southbound exit and entrance only; connects to the Rodeo Trailhead at the Golden Gate NRA |
| Marin MRN L0.00-27.63 | Sausalito | 3.33 | 445A | Sausalito (Bridgeway), Marin City (Donahue Street) | |
| Marin MRN L0.00-27.63 | Sausalito | 4.46 | 445B | SR 1 north – Mill Valley, Stinson Beach | Northern end of SR 1 overlap; Mill Valley not signed southbound |
| Marin MRN L0.00-27.63 | Strawberry | 4.78 | 446 | Seminary Drive | |
| Marin MRN L0.00-27.63 | Strawberry | ​ | | Redwood Highway Frontage Road (unsigned) | Southbound exit only |
| Marin MRN L0.00-27.63 | Strawberry | 5.70 | 447 | SR 131 east (Tiburon Boulevard) / East Blithedale Avenue | |
| Marin MRN L0.00-27.63 | Corte Madera | ​ | | Casa Buena Drive | Southbound entrance only |
| Marin MRN L0.00-27.63 | Corte Madera | 7.37 | 449A | Paradise Drive, Tamalpais Drive | Signed as exit 449 northbound |
| Marin MRN L0.00-27.63 | Corte Madera | 7.66 | 449B | Madera Boulevard | Southbound exit and entrance |
| Marin MRN L0.00-27.63 | Corte Madera | 8.02 | 450A | Lucky Drive, Doherty Drive | Doherty Drive not signed northbound |
| Marin MRN L0.00-27.63 | Larkspur | 8.60 | 450B | San Anselmo, Richmond Bridge | Northbound signage |
| Marin MRN L0.00-27.63 | Larkspur | 8.60 | 450B | Sir Francis Drake Boulevard | Southbound signage |
| Marin MRN L0.00-27.63 | San Rafael | 9.63 | 451A | Andersen Drive, Francisco Boulevard | Southbound exit and entrance |
| Marin MRN L0.00-27.63 | San Rafael | 10.00 | 451 | Francisco Boulevard to I-580 east – Richmond Bridge | Northbound exit only |
| Marin MRN L0.00-27.63 | San Rafael | 10.00 | 451B | I-580 east – Richmond Bridge, Oakland | Southbound exit and northbound entrance; I-580 west exit 1A; former SR 17 south |
| Marin MRN L0.00-27.63 | San Rafael | 10.72 | 452 | Central San Rafael (Second Street, Mission Avenue) | |
| Marin MRN L0.00-27.63 | San Rafael | 12.19 | 454A | Lincoln Avenue | No northbound exit |
| Marin MRN L0.00-27.63 | San Rafael | 12.69 | 454B | North San Pedro Road | Signed as exit 454 northbound |
| Marin MRN L0.00-27.63 | San Rafael | 13.71 | 455 | Freitas Parkway – Terra Linda | |
| Marin MRN L0.00-27.63 | San Rafael | 14.71 | 456 | Lucas Valley Road, Smith Ranch Road | |
| Marin MRN L0.00-27.63 | ​ | 15.57 | 457 | St. Vincent Drive, Miller Creek Road | |
| Marin MRN L0.00-27.63 | Novato | 16.64 | 458 | Nave Drive | Northbound signage |
| Marin MRN L0.00-27.63 | Novato | 16.64 | 458 | Alameda del Prado | Southbound signage |
| Marin MRN L0.00-27.63 | Novato | 18.09 | 459 | Ignacio Boulevard, Bel Marin Keys Boulevard, Entrada Drive – Hamilton Field | Entrada Drive, Hamilton Field not signed northbound; signed as exits 459A (Bel Marin Keys Boulevard, Hamilton Field) and 459B (Ignacio Boulevard, Entrada Drive) southbound |
| Marin MRN L0.00-27.63 | Novato | 18.94 | 460 | SR 37 east / South Novato Boulevard – Napa, Vallejo | Signed as exits 460A (SR 37) and 460B (South Novato Boulevard) northbound |
| Marin MRN L0.00-27.63 | Novato | R20.19 | 462A | Rowland Boulevard (US 101 Bus. north) | |
| Marin MRN L0.00-27.63 | Novato | R21.11 | 462B | De Long Avenue | Serves Downtown Novato |
| Marin MRN L0.00-27.63 | Novato | R22.00 | 463 | Atherton Avenue, San Marin Drive (US 101 Bus. south) | |
| Marin MRN L0.00-27.63 | ​ | 26.90 | 467 | San Antonio Road, Silveira Ranch Road | |
| Sonoma | ​ | 2.94 | 472A | Petaluma Boulevard South (US 101 Bus. north), Kastania Road | |
| Sonoma | Petaluma | 3.58 | 472B | SR 116 east – Sonoma, Napa | Southern end of SR 116 overlap |
| Sonoma | Petaluma | 4.76 | 474 | East Washington Street – Central Petaluma | |
| Sonoma | Petaluma | 5.76 | 476 | Old Redwood Highway, Petaluma Boulevard North (US 101 Bus. south) – Penngrove | |
| Sonoma | ​ | ​ | | Stony Point Road | Southbound entrance only |
| Sonoma | ​ | 10.67 | 479 | Railroad Avenue | Northbound exit only |
| Sonoma | Cotati | 12.00 | 481A | West Sierra Avenue | Northbound exit and southbound entrance |
| Sonoma | Cotati | 12.69 | 481B | SR 116 west (Gravenstein Highway) – Rohnert Park, Sebastopol, Cotati | Northern end of SR 116 overlap; signed as exit 481 southbound |
| Sonoma | Rohnert Park | 13.88 | 483 | Rohnert Park Expressway | |
| Sonoma | Rohnert Park | 15.02 | 484A | Golf Course Drive, Wilfred Avenue | Signed as exit 484 southbound |
| Sonoma | ​ | 15.53 | 484B | Santa Rosa Avenue (US 101 Bus. north) | Northbound exit and southbound entrance |
| Sonoma | ​ | 16.54 | 485 | Todd Road | |
| Sonoma | Santa Rosa | 18.49 | 487 | Yolanda Avenue, Hearn Avenue | Yolanda Avenue not signed southbound |
| Sonoma | Santa Rosa | 19.00 | 488A | Baker Avenue | Northbound signage |
| Sonoma | Santa Rosa | 19.00 | 488A | Corby Avenue, Santa Rosa Avenue | Southbound signage |
| Sonoma | Santa Rosa | 19.66 | 488B | SR 12 – Sebastopol, Sonoma | SR 12 west exits 7A-B, east exit 7 |
| Sonoma | Santa Rosa | 20.09 | 489 | Third Street – Downtown Santa Rosa | Third Street not signed southbound |
| Sonoma | Santa Rosa | 20.74 | 490 | College Avenue | |
| Sonoma | Santa Rosa | 21.74 | 491A | Steele Lane, Guerneville Road | Signed as exit 491 southbound |
| Sonoma | Santa Rosa | 22.52 | 491B | Bicentennial Way | Northbound exit and southbound entrance |
| Sonoma | Santa Rosa | 22.81 | 492 | Mendocino Avenue (US 101 Bus. south), Old Redwood Highway, Hopper Avenue | Hopper Avenue not signed northbound; Old Redwood Highway not signed southbound |
| Sonoma | ​ | 24.86 | 494 | River Road – Guerneville, Calistoga | |
| Sonoma | ​ | 25.90 | 495A | Fulton Road – Fulton | Closed after the reconstruction of the Airport Boulevard interchange |
| Sonoma | ​ | 26.33 | 495 | Airport Boulevard, Fulton Road – Fulton | |
| Sonoma | Windsor | 27.62 | 496 | Shiloh Road | |
| Sonoma | Windsor | 29.35 | 498 | Old Redwood Highway – Central Windsor | |
| Sonoma | Windsor | 30.67 | 499 | Arata Lane | No northbound entrance |
| Sonoma | Healdsburg | 33.48 | 502 | Healdsburg Avenue | Northbound signage |
| Sonoma | Healdsburg | 33.48 | 502 | Old Redwood Highway | Southbound signage |
| Sonoma | Healdsburg | 34.55 | 503 | Central Healdsburg (Healdsburg Avenue) | Northbound exit and southbound entrance |
| Sonoma | Healdsburg | 34.88 | 504 | Westside Road – Guerneville | Southbound exit and northbound entrance |
| Sonoma | Healdsburg | 36.27 | 505 | Dry Creek Road | |
| Sonoma | ​ | R38.56 | 507 | Lytton Springs Road, Alexander Valley Road | |
| Sonoma | ​ | R40.03 | 509 | Independence Lane | |
| Sonoma | Geyserville | R41.43 | 510 | Geyserville Avenue to SR 128 east – Geyserville | |
| Sonoma | Geyserville | R43.37 | 512 | SR 128 east / Canyon Road (CR C1) – Geyserville, Calistoga | Southern end of SR 128 overlap |
| Sonoma | ​ | R47.85 | 517 | Asti (Asti Road) | |
| Sonoma | ​ | R49.05 | 518 | Dutcher Creek Road – Stewarts Point | |
| Sonoma | Cloverdale | R50.43 | 519 | South Cloverdale Boulevard (US 101 Bus. north, SR 128 Bus. west) | |
| Sonoma | Cloverdale | R51.62 | 520 | Citrus Fair Drive | |
| Sonoma | ​ | R53.40 | 522 | SR 128 west (US 101 Bus. south) – Fort Bragg, Mendocino | Northern end of SR 128 overlap |
| Mendocino MEN R0.10-T106.80 | ​ | 0.48 | 525 | Geysers Road | |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Mendocino MEN R0.10-T106.80 | Hopland | 10.89 | | SR 175 east – Lakeport | |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Mendocino MEN R0.10-T106.80 | ​ | 19.68 | 544 | Burke Hill Drive | |
| Mendocino MEN R0.10-T106.80 | ​ | 20.71 | 545 | Cox-Shrader Road | |
| Mendocino MEN R0.10-T106.80 | ​ | R21.59 | 546 | SR 253 west – Ukiah, Boonville | |
| Mendocino MEN R0.10-T106.80 | Ukiah | R23.45 | 548A | Talmage (SR 222) | |
| Mendocino MEN R0.10-T106.80 | Ukiah | R24.06 | 548B | Gobbi Street | |
| Mendocino MEN R0.10-T106.80 | Ukiah | R24.53 | 549 | Perkins Street, Vichy Springs Road – Central Ukiah | |
| Mendocino MEN R0.10-T106.80 | Ukiah | R26.16 | 551 | North State Street – Ukiah | |
| Mendocino MEN R0.10-T106.80 | ​ | 27.41 | 552 | Lake Mendocino Drive | |
| Mendocino MEN R0.10-T106.80 | ​ | 30.43 | 555A | Calpella (Moore Street, Central Avenue) | |
| Mendocino MEN R0.10-T106.80 | ​ | 30.83 | 555B | SR 20 east – Upper Lake, Williams | Southern end of SR 20 overlap |
| Mendocino MEN R0.10-T106.80 | ​ | R32.63 | 557 | West Road – Redwood Valley | |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Mendocino MEN R0.10-T106.80 | ​ | 41.06 | Ridgewood Summit, elevation 1,956 feet (596 m) | Ridgewood Summit, elevation 1,956 feet (596 m) | Ridgewood Summit, elevation 1,956 feet (596 m) |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | 568 | SR 20 west – Willits, Fort Bragg | Northern end of SR 20 overlap; former US 101 north |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | 573 | North Main Street | Former US 101 south |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Mendocino MEN R0.10-T106.80 | ​ | 58.90 | Moss Cove Rest Area (southbound only) | Moss Cove Rest Area (southbound only) | Moss Cove Rest Area (southbound only) |
| Mendocino MEN R0.10-T106.80 | Longvale | 59.31 | | SR 162 east – Covelo, Round Valley | |
| Mendocino MEN R0.10-T106.80 | ​ | 61.82 | | Irvine Lodge Road – Irvine Lodge Rest Area | No left turn from US 101 south |
| Mendocino MEN R0.10-T106.80 | ​ | 82.50 | Empire Camp Rest Area (northbound only) | Empire Camp Rest Area (northbound only) | Empire Camp Rest Area (northbound only) |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Mendocino MEN R0.10-T106.80 | ​ | R84.69 | 609 | SR 271 north | Former US 101 north |
| Mendocino MEN R0.10-T106.80 | South Leggett | R89.57 | 614 | South Leggett (SR 271) | Former US 101 |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Mendocino MEN R0.10-T106.80 | Leggett | T91.25 | | SR 1 south – Leggett, Fort Bragg | Former SR 208 south |
| Mendocino MEN R0.10-T106.80 | South Fork Eel River | R99.51– R100.02 | Confusion Hill Bridges | Confusion Hill Bridges | Confusion Hill Bridges |
| Mendocino MEN R0.10-T106.80 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Mendocino MEN R0.10-T106.80 | Reynolds | R101.89 | 625 | SR 271 | Former US 101 |
| Mendocino MEN R0.10-T106.80 | Piercy | R103.81 | 627 | Piercy (SR 271) | Former US 101 |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Humboldt HUM T0.00-R137.44 | Cooks Valley | T0.08 | | SR 271 south – Piercy, Cooks Valley | Former US 101 south |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Humboldt HUM T0.00-R137.44 | Benbow | R8.60 | 636 | Benbow (Lake Benbow Drive) | |
| Humboldt HUM T0.00-R137.44 | Garberville | R11.13 | 639A | Sprowel Creek Road (US 101 Bus. north) – Garberville | No northbound entrance |
| Humboldt HUM T0.00-R137.44 | Garberville | R11.50 | 639B | Garberville, Redway (Redwood Drive) | No southbound entrance |
| Humboldt HUM T0.00-R137.44 | ​ | R14.31 | 642 | Redwood Drive (US 101 Bus. south) – Redway | |
| Humboldt HUM T0.00-R137.44 | ​ | R17.91 | 645 | Avenue of the Giants (SR 254), Hooker Creek Road – Phillipsville | Hooker Creek Road not signed northbound; Avenue of the Giants not signed southbound |
| Humboldt HUM T0.00-R137.44 | ​ | R22.44 | 650 | Miranda, Phillipsville (Maple Hills Road) | |
| Humboldt HUM T0.00-R137.44 | ​ | 25.01 | 653 | Salmon Creek Road | |
| Humboldt HUM T0.00-R137.44 | Myers Flat | 27.94 | 656 | Myers Flat (SR 254) | |
| Humboldt HUM T0.00-R137.44 | ​ | 33.22 | 661 | Weott (Newton Road) | |
| Humboldt HUM T0.00-R137.44 | ​ | 35.70 | 663 | South Fork, Honeydew (SR 254) | |
| Humboldt HUM T0.00-R137.44 | ​ | 39.16 | 667A | Avenue of the Giants (SR 254) | Southbound exit only |
| Humboldt HUM T0.00-R137.44 | ​ | R39.67 | 667 | Redcrest, Holmes (Sorenson Road) | |
| Humboldt HUM T0.00-R137.44 | ​ | R43.32 | 671 | Pepperwood, Redcrest, Holmes (Barkdull Road) | |
| Humboldt HUM T0.00-R137.44 | ​ | R45.90 | 674 | Avenue of the Giants (SR 254), Jordan Road – Pepperwood | Avenue of the Giants not signed northbound; Jordan Road not signed southbound |
| Humboldt HUM T0.00-R137.44 | ​ | R47.95 | 676 | Stafford Road | |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Humboldt HUM T0.00-R137.44 | ​ | R51.84 | 679 | Rio Dell, Scotia (SR 283, US 101 Bus. north) | |
| Humboldt HUM T0.00-R137.44 | Rio Dell | R52.60 | 680 | Davis Street | |
| Humboldt HUM T0.00-R137.44 | Rio Dell | R53.38 | 681 | Wildwood Avenue (US 101 Bus. south) – Rio Dell | |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Humboldt HUM T0.00-R137.44 | Fortuna | 57.69 | 685 | SR 36 east – Hydesville, Bridgeville | |
| Humboldt HUM T0.00-R137.44 | Fortuna | 59.50 | 687 | Kenmar Road (US 101 Bus. north), Riverwalk Drive | Riverwalk Drive not signed southbound |
| Humboldt HUM T0.00-R137.44 | Fortuna | 60.49 | 688 | 12th Street | |
| Humboldt HUM T0.00-R137.44 | Fortuna | 61.53 | 689 | Main Street (US 101 Bus. south) | |
| Humboldt HUM T0.00-R137.44 | Fortuna | 62.23 | 690 | Palmer Boulevard | |
| Humboldt HUM T0.00-R137.44 | Fernbridge | 63.10 | 691 | Fernbridge, Ferndale (Fernbrige Drive to SR 211) | Northbound exit and southbound entrance |
| Humboldt HUM T0.00-R137.44 | Fernbridge | 64.30 | 692 | Loleta, Fernbridge, Ferndale (SR 211) | |
| Humboldt HUM T0.00-R137.44 | ​ | 65.95 | 694 | Loleta Drive | |
| Humboldt HUM T0.00-R137.44 | ​ | 68.21 | 696 | Hookton Road – Loleta | |
| Humboldt HUM T0.00-R137.44 | Humboldt Hill | 70.61 | 698 | College of the Redwoods (Tompkins Hill Road) | |
| Humboldt HUM T0.00-R137.44 | Humboldt Hill | 72.03 | 699 | Fields Landing (Orchard Avenue, Fields Landing Drive) | |
| Humboldt HUM T0.00-R137.44 | Humboldt Hill | 72.88 | 700 | King Salmon Avenue | |
| Humboldt HUM T0.00-R137.44 | Humboldt Hill | 73.72 | 701 | Humboldt Hill Road – Humboldt Hill | |
| Humboldt HUM T0.00-R137.44 | Eureka | 74.77 | 702 | Herrick Avenue, Elk River Road | |
| Humboldt HUM T0.00-R137.44 | Eureka | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Humboldt HUM T0.00-R137.44 | Eureka | 79.17 | | SR 255 north (R Street) / Myrtle Avenue – Samoa | |
| Humboldt HUM T0.00-R137.44 | Arcata | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Humboldt HUM T0.00-R137.44 | Arcata | 85.03 | 712 | South G Street | Southbound exit and entrance |
| Humboldt HUM T0.00-R137.44 | Arcata | 85.83 | 713 | SR 255 south (Samoa Boulevard) – Arcata, Samoa, Sunny Brae | |
| Humboldt HUM T0.00-R137.44 | Arcata | 86.50 | 714A | 14th Street – Humboldt State University | Northbound exit and southbound entrance |
| Humboldt HUM T0.00-R137.44 | Arcata | 86.94 | 714B | Sunset Avenue – Arcata, Humboldt State University | Signed as exit 714 southbound |
| Humboldt HUM T0.00-R137.44 | Arcata | 88.27 | 716A | SR 299 east – Weaverville, Redding | Former US 299 |
| Humboldt HUM T0.00-R137.44 | Arcata | 88.80 | 716B | Giuntoli Lane, Janes Road | |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R90.13 | 718 | SR 200 east (North Bank Road) / Central Avenue (US 101 Bus. north) – McKinleyville | Central Avenue not signed southbound |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R91.47 | 719 | School Road | |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R93.00 | 721 | Murray Road | |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R93.85 | 722 | Arcata–Eureka Airport (Airport Road) | |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R95.62 | 723 | North Central Avenue (US 101 Bus. south) – McKinleyville | |
| Humboldt HUM T0.00-R137.44 | McKinleyville | R97.02 | 725 | Crannell Road | |
| Humboldt HUM T0.00-R137.44 | ​ | 98.07 | 726A | Westhaven Drive | Northbound exit and southbound entrance |
| Humboldt HUM T0.00-R137.44 | ​ | 98.36 | 726B | 6th Avenue – Westhaven | Signed as exit 726 southbound |
| Humboldt HUM T0.00-R137.44 | Trinidad | 100.71 | 728 | Trinidad (North Westhaven Drive, Main Street) | |
| Humboldt HUM T0.00-R137.44 | ​ | R102.90 | Trinidad – Southbound Rest Area | Trinidad – Southbound Rest Area | Trinidad – Southbound Rest Area |
| Humboldt HUM T0.00-R137.44 | ​ | R103.37 | 731 | Seawood Drive | |
| Humboldt HUM T0.00-R137.44 | ​ | R105.14 | Trinidad – Northbound Rest Area | Trinidad – Northbound Rest Area | Trinidad – Northbound Rest Area |
| Humboldt HUM T0.00-R137.44 | ​ | R106.06 | 734 | Patricks Point Drive | |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Humboldt HUM T0.00-R137.44 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Humboldt HUM T0.00-R137.44 | ​ | R126.09 | 753 | Newton B. Drury Scenic Parkway north | Former US 101 north |
| Del Norte DN M0.00-46.49 | ​ | R0.15 | 765 | Newton B. Drury Scenic Parkway south | Former US 101 south |
| Del Norte DN M0.00-46.49 | ​ | R3.56 | 768 | Klamath Beach Road (CR D8) | |
| Del Norte DN M0.00-46.49 | Klamath | R4.64 | 769 | SR 169 east – Klamath, Terwer Valley | |
| Del Norte DN M0.00-46.49 | Klamath | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Del Norte DN M0.00-46.49 | Klamath | ​ | | Requa Road (CR D7) / Minot Creek Road | |
| Del Norte DN M0.00-46.49 | Crescent City | 25.84 | | Elk Valley Road (CR D2) – Elk Valley Rancheria | |
| Del Norte DN M0.00-46.49 | Crescent City | 27.01 | | CR D3 (Northcrest Drive) | |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Parkway Drive to Washington Boulevard | Northbound exit and entrance; interchange |
| Del Norte DN M0.00-46.49 | ​ | ​ | Southern end of freeway | Southern end of freeway | Southern end of freeway |
| Del Norte DN M0.00-46.49 | ​ | R27.87 | 791 | Washington Boulevard (CR D1) | No northbound exit |
| Del Norte DN M0.00-46.49 | ​ | R30.81 | 794 | US 199 north (Redwood Highway north) to I-5 – Grants Pass | Northbound exit and southbound entrance; US 101 south transitions onto Redwood Highway south |
| Del Norte DN M0.00-46.49 | ​ | ​ | Northern end of freeway | Northern end of freeway | Northern end of freeway |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Elk Valley Cross Road (CR D2) to US 199 – Grants Pass | |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Lake Earl Drive (CR D3) – Pelican Bay State Prison | |
| Del Norte DN M0.00-46.49 | ​ | 36.26 | | SR 197 south (North Bank Road) | |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Fred D. Haight Drive (CR D4) | |
| Del Norte DN M0.00-46.49 | Smith River | 39.83 | | Fred D. Haight Drive (CR D4) – Smith River | |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Sarina Road, Ocean View Drive (CR D5) | |
| Del Norte DN M0.00-46.49 | Smith River Rancheria | ​ | | Mouth Smith River Road (CR D6) | |
| Del Norte DN M0.00-46.49 | ​ | ​ | | Ocean View Drive (CR D5) | |
| Del Norte DN M0.00-46.49 | ​ | 46.20 | Agricultural Inspection Station (southbound only) | Agricultural Inspection Station (southbound only) | Agricultural Inspection Station (southbound only) |
| Del Norte DN M0.00-46.49 | ​ | 46.49 | | US 101 north – Oregon Coast, Portland | Continuation into Oregon |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Closed/former Concurrency terminus Electronic toll collection HOV only Incomplete access Route transition Unopened ||||||