# 2022 Internazionali di Tennis Città di Vicenza – Singles

Alessandro Giannessi was the defending champion but chose not to defend his title.
Andrea Pellegrino won the title after defeating Andrea Collarini 6–1, 6–4 in the final.

## Seeds

* Gianluca Mager (quarterfinals)
* Juan Manuel Cerúndolo (quarterfinals)
* Andreas Seppi (first round)
* Flavio Cobolli (second round)
* Renzo Olivo (second round)
* Dmitry Popko (first round)
* Lorenzo Giustino (first round)
* Salvatore Caruso (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| Alt | Andrea Pellegrino | 4 | 6 | 6 | | | | |
| WC | Matteo Gigante | 6 | 3 | 3 | | | | |
| WC | Matteo Gigante | 6 | 3 | 3 | Alt | Andrea Pellegrino | 6 | 6 |
| | | | | | | Andrea Collarini | 1 | 4 |
| Alt | Daniel Dutra da Silva | 2 | 1 | | | Andrea Collarini | 1 | 4 |
| | Andrea Collarini | 6 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | G Mager | 6 | 7$^7$ | | | | | | | | | | | | | | | |
| LL | Yan Bondarevskiy | 3 | 6$^3$ | | 1 | G Mager | 7 | 6 | | | | | | | | | | |
| | R Bonadio | 2 | 6 | 6 | | R Bonadio | 5 | 2 | | | | | | | | | | |
| Alt | M Janvier | 6 | 3 | 3 | | | | | 1 | G Mager | 4 | 6 | 2 | | | | | |
| Q | G Fonio | 6 | 6 | | | | | | Alt | A Pellegrino | 6 | 4 | 6 | | | | | |
| | GA Olivieri | 3 | 4 | | Q | G Fonio | 6$^8$ | 3 | | | | | | | | | | |
| Alt | A Pellegrino | 6 | 6 | | Alt | A Pellegrino | 7$^{10}$ | 6 | | | | | | | | | | |
| 7 | L Giustino | 4 | 4 | | | | | | | | | | | Alt | A Pellegrino | 4 | 6 | 6 |
| 3 | A Seppi | 1 | 6$^5$ | | | | | | | | | | | WC | M Gigante | 6 | 3 | 3 |
| | A Arnaboldi | 6 | 7$^7$ | | | A Arnaboldi | 6 | 6 | | | | | | | | | | |
| SE | F Maestrelli | 6 | 6 | | SE | F Maestrelli | 3 | 2 | | | | | | | | | | |
| Q | K de Schepper | 4 | 2 | | | | | | | A Arnaboldi | 4 | 5 | | | | | | |
| Alt | A Galarneau | 4 | 6 | 3 | | | | | WC | M Gigante | 6 | 7 | | | | | | |
| WC | M Gigante | 6 | 2 | 6 | WC | M Gigante | 6 | 7$^7$ | | | | | | | | | | |
| | V Sachko | 3 | 6$^2$ | | 5 | R Olivo | 3 | 6$^5$ | | | | | | | | | | |
| 5 | R Olivo | 6 | 7$^7$ | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8/WC | S Caruso | 6 | 5 | 4 | | | | | | | | | | | | | | |
| Q | O Prihodko | 4 | 7 | 6 | Q | O Prihodko | 2 | 6 | 2 | | | | | | | | | |
| Q | N Barrientos | 0 | 4 | | Alt | D Dutra da Silva | 6 | 2 | 6 | | | | | | | | | |
| Alt | D Dutra da Silva | 6 | 6 | | | | | | | Alt | D Dutra da Silva | 5 | 7 | 7$^7$ | | | | |
| SE | M Arnaldi | 5 | 6 | 6 | | | | | | SE | M Arnaldi | 7 | 5 | 6$^4$ | | | | |
| | N Moreno de Alboran | 7 | 3 | 1 | SE | M Arnaldi | 6 | 4 | 6 | | | | | | | | | |
| WC | F Passaro | 6 | 4 | 4 | 4 | F Cobolli | 4 | 6 | 4 | | | | | | | | | |
| 4 | F Cobolli | 2 | 6 | 6 | | | | | | | | | | | Alt | D Dutra da Silva | 2 | 1 |
| 6 | D Popko | 6 | 1 | 2 | | | | | | | | | | | | A Collarini | 6 | 6 |
| Q | F Comesaña | 2 | 6 | 6 | Q | F Comesaña | 2 | 2 | | | | | | | | | | |
| | L Rosol | 0 | 3 | | | A Collarini | 6 | 6 | | | | | | | | | | |
| | A Collarini | 6 | 6 | | | | | | | | A Collarini | 6 | 6 | | | | | |
| Alt | L Darderi | 6 | 3 | 6 | | | | | | 2 | JM Cerúndolo | 2 | 3 | | | | | |
| Alt | N Fatić | 3 | 6 | 4 | Alt | L Darderi | 4 | 1 | | | | | | | | | | |
| | A Müller | 5 | 4 | | 2 | JM Cerúndolo | 6 | 6 | | | | | | | | | | |
| 2 | JM Cerúndolo | 7 | 6 | | | | | | | | | | | | | | | |