# 2025 Challenger de Santiago – Singles

Juan Pablo Varillas was the defending champion but lost in the first round to Matheus Pucinelli de Almeida.
Daniel Elahi Galán won the title after defeating Thiago Monteiro 7–5, 6–3 in the final.

## Seeds

* Thiago Monteiro (final)
* Daniel Elahi Galán (champion)
* Tomás Barrios Vera (second round)
* Juan Pablo Ficovich (first round)
* Daniel Vallejo (first round)
* Juan Pablo Varillas (first round)
* Murkel Dellien (second round)
* Andrea Collarini (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Thiago Monteiro | 7 | 7$^7$ | | | | |
| | Ignacio Buse | 5 | 6$^4$ | | | | |
| | Ignacio Buse | 5 | 6$^4$ | 1 | Thiago Monteiro | 5 | 3 |
| | | | | 2 | Daniel Elahi Galán | 7 | 6 |
| | Emilio Nava | 6$^8$ | 2 | 2 | Daniel Elahi Galán | 7 | 6 |
| 2 | Daniel Elahi Galán | 7$^{10}$ | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | T Monteiro | 7 | 6$^1$ | 6 | | | | | | | | | | | | | | |
| | M Alves | 5 | 7$^7$ | 3 | 1 | T Monteiro | 7 | 7 | | | | | | | | | | |
| | L Midón | 6 | 7 | | | L Midón | 5 | 5 | | | | | | | | | | |
| Q | P Boscardin Dias | 2 | 5 | | | | | | | 1 | T Monteiro | 3 | 6 | 6 | | | | |
| Q | Guido Iván Justo | 2 | 7$^7$ | 5$^r$ | | | | | | | GA Olivieri | 6 | 3 | 3 | | | | |
| | GA Olivieri | 6 | 6$^3$ | 6 | | GA Olivieri | 6 | 2 | 7 | | | | | | | | | |
| | Karue Sell | 2 | 4 | | 7 | M Dellien | 3 | 6 | 5 | | | | | | | | | |
| 7 | M Dellien | 6 | 6 | | | | | | | | | | | | 1 | T Monteiro | 7 | 7$^7$ |
| 3 | T Barrios Vera | 3 | 6 | 7 | | | | | | | | | | | | I Buse | 5 | 6$^4$ |
| WC | Diego Dedura-Palomero | 6 | 2 | 5 | 3 | T Barrios Vera | 3 | 1 | | | | | | | | | | |
| Q | JL Reis da Silva | 6 | 6 | | Q | JL Reis da Silva | 6 | 6 | | | | | | | | | | |
| | M Soto | 4 | 3 | | | | | | | Q | JL Reis da Silva | 2 | 2 | | | | | |
| | I Buse | 6 | 2 | 6 | | | | | | | I Buse | 6 | 6 | | | | | |
| | Pol Martín Tiffon | 3 | 6 | 2 | | I Buse | 6 | 7$^7$ | | | | | | | | | | |
| Q | K Feldbausch | 6 | 6 | | Q | K Feldbausch | 3 | 6$^2$ | | | | | | | | | | |
| 5 | AD Vallejo | 2 | 2 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | A Collarini | 4 | 6 | 6 | | | | | | | | | | | | | | |
| | Á Guillén Meza | 6 | 4 | 4 | 8 | A Collarini | 6 | 6 | | | | | | | | | | |
| WC | Nicolás Vilallón | 4 | 6 | 3 | Q | Y Mochizuki | 2 | 1 | | | | | | | | | | |
| Q | Yuki Mochizuki | 6 | 3 | 6 | | | | | | 8 | A Collarini | 7 | 3 | 3 | | | | |
| | D Popko | 3 | 4 | | | | | | | | Em Nava | 5 | 6 | 6 | | | | |
| | G Bueno | 6 | 6 | | | G Bueno | 6 | 1 | 3 | | | | | | | | | |
| | Em Nava | 6 | 6 | | | Em Nava | 1 | 6 | 6 | | | | | | | | | |
| 4 | JP Ficovich | 0 | 4 | | | | | | | | | | | | | Em Nava | 6$^8$ | 2 |
| 6 | JP Varillas | 3 | 6 | 2 | | | | | | | | | | | 2 | DE Galán | 7$^{10}$ | 6 |
| | M Pucinelli de Almeida | 6 | 3 | 6 | | M Pucinelli de Almeida | 6$^2$ | 6 | 6 | | | | | | | | | |
| Alt | R Olivo | 6 | 3 | 7$^7$ | Alt | R Olivo | 7$^7$ | 2 | 1 | | | | | | | | | |
| Q | PA Saraiva dos Santos | 3 | 6 | 6$^5$ | | | | | | | M Pucinelli de Almeida | 6$^4$ | 6$^4$ | | | | | |
| WC | Benjamín Torrealba | 0 | 2 | | | | | | | 2 | DE Galán | 7$^7$ | 7$^7$ | | | | | |
| | P Sakamoto | 6 | 6 | | | P Sakamoto | 3 | 4 | | | | | | | | | | |
| | JB Torres | 4 | 4 | | 2 | DE Galán | 6 | 6 | | | | | | | | | | |
| 2 | DE Galán | 6 | 6 | | | | | | | | | | | | | | | |