# List of miscellaneous 5-HT2A receptor agonists

This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT$_{2A}$ (and other 5-HT$_2$ subtypes to a varying extent) that fall outside the common structural classes. Most agonists at this receptor are either substituted phenethylamine derivatives from the 2C, DOx and 25-NB groups, or substituted tryptamines and related compounds along with more complex derivatives of these such as lysergamides and iboga-type alkaloids. There are however numerous 5-HT$_{2A}$ receptor agonists which do not fall within any of these groups, some representative examples of which are listed below. K$_i$ and EC$_{50}$ values vary depending on the assay conditions used and so may not be directly comparable between sources. Many of these compounds have been designed to be non-psychoactive derivatives for medical applications, and it should not be assumed that a compound which acts as a 5-HT$_{2A}$ agonist will necessarily be psychedelic in nature.
| Name | Chemical name | h5-HT$_{2A}$ K$_i$ (EC$_{50}$) (nM) | PubChem | CAS number |
| Compound 11a | 11-chloro-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole | 6.5 | 20726100 | 599173-28-1 |
| Compound 23 | 9-Chloro-7-(2-ethoxy-phenyl)-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole | 32 | 44315398 | 599173-25-8 |
| Compound 10d | 7-Benzyloxy-8-bromo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | 22 | 10472780 | 616201-60-6 |
| Example 22.67 | 4-(6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-2-yl)thiomorpholine | 21 | 44124494 | 1003589-43-2 |
| Compound 3d (N-Bn-THAZ) | 2-benzyl-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-3-one | (549) | 14515725 | 125115-66-4 |
| Compound 11 | (3R)-N,N-diethyl-5-(1H-indol-4-yl)-1-methyl-3,6-dihydro-2H-pyridine-3-carboxamide | (<10) | 156278040 | 2640392-28-3 |
| Compound 106 | 6-chloro-1-(2,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | | 4376990 | 528525-37-3 |
| Compound 6c | (6S)-2,3-dichloro-7,8,9,10-tetrahydro-6H-6,9-epiminocyclohepta[b]quinoxaline | (400) | | 2991367-88-3 |
| Compound 70 | 3-(4-bromo-2-methylpyrazol-3-yl)-N-(4-chlorophenyl)-4-methoxyaniline | 1.77 | 9952456 | 720702-40-9 |
| Compound 22 | 7-(trifluoromethoxy)-2,3,4,10b-tetrahydro-1H-pyrazino[1,2-b]isoindol-6-one | 67 (87) | 11448649 | 850033-15-7 |
| Example 1 (ZC-B) | 3-(4-bromo-2,5-dimethoxyphenyl)azetidine | (1.6) | 156337249 | 2641630-65-9 |
| 2C-B-aminorex | 5-(4-bromo-2,5-dimethoxyphenyl)-4,5-dihydro-1,3-oxazol-2-amine | | 165360199 | |
| 2-(2,5-dimethoxy-4-bromophenyl)morpholine | 2-(2,5-dimethoxy-4-bromophenyl)morpholine | 20.6 | 11429275 | 807631-07-8 |
| DM-506 (ibogaminalog) | 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole | | 24183 | 7546-66-9 |
| LPH-5 | (3S)-3-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]piperidine | (3.2) | 156337168 | 2641630-97-7 |
| 2C-B-PP | 1-(2,5-dimethoxy-4-bromophenyl)piperazine | | 4738744 | 100939-87-5 |
| ENX-105 | 5-chloro-2-methoxy-N-((2R,3R)-2-methyl-1-(phenylmethyl-d2)pyrrolidin-3-yl)-4-((methyl-d3)amino)benzamide | | | 2950168-16-6 |
| cis-urocanic acid (cis-UCA) | (Z)-3-(1H-imidazol-5-yl)prop-2-enoic acid | 4.6 | 1549103 | 7699-35-6 |
| CPD-1 | (3S)-3-Methyl-1-[4-(trifluoromethyl)-1-benzofuran-7-yl]piperazine | | 9925822 | 325145-37-7 |
| Efavirenz | (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one | | 64139 | 154598-52-4 |
| IHCH-7079 | (6bR,10aS)-8-(2-Methoxyphenethyl)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline | | 169488014 | 2957888-63-8 |
| IHCH-7113 | (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline | | 21302499 | 313368-85-3 |
| ITI-1549 | ? | 10.2 | ? | ? |
| NDTDI | N,N-diethyl-3-[methyl(1,3,4,5-tetrahydrobenzo[cd]indol-4-yl)amino]propanamide | | 163192742 | |
| Mefloquine | 2,8-bis(trifluoromethyl)quinolin-4-yl-(2-piperidyl)methanol | | 40692 | 53230-10-7 |
| ORG-12962 | 1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine | | 9796408 | 210821-63-9 |
| ORG-37684 | (3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine | | 9794656 | 213007-95-5 |
| OSU-6162 | (3S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine | | 9795741 | 156907-84-5 |
| PHA-57378 | 2,7,8,9,10,11-hexahydro-1H-azepino[4,5-b][1,4]oxazino[2,3,4-hi]indole | 4.1 | 10198481 | 303798-94-9 |
| P-54 | 2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-N,N-dimethylethanamine | | 168946740 | 2943954-59-2 |
| I-28 | N-[2-(8-methoxynaphthalen-1-yl)ethyl]-N-methylpropan-2-amine | | 170604481 | 3019268-34-6 |
| (R)-69 | 3-[(5R)-5-methyl-1,2,5,6-tetrahydropyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine | | 164513426 | 2765652-48-8 |
| RS134-49 | 4-methyl-3-(1,2,3,6-tetrahydropyridin-5-yl)-1H-indole | | 168941768 | 2945139-94-4 |
| RH-34 | 3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione | | 10041987 | 1028307-48-3 |
| SCHEMBL5334361 | 7-[(3-methoxyphenoxy)methyl]-2,3,4,5-tetrahydro-1H-3-benzazepine | (0.4) | 59027940 | 959867-47-1 |
| Tabernanthalog | 8-methoxy-3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole | | 146026994 | 2483829-59-8 |
| TKU-II-100 | [(1S,2S)-2-(2-fluorophenyl)cyclopropyl]methanamine | 0.62 | 44572747 | 1821802-54-3 |
| WAY-470 | 1,16-diazatetracyclo[8.8.1.0$^{2,9}$.0$^{14,19}$]nonadeca-2(9),10,12,14(19)-tetraene | 36 | 10037962 | 422318-22-7 |
| WXVL_BT0793LQ2118 | 6-fluoro-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-indole | | | |
| Z2825713589 | (4-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-(6-methoxypyrazin-2-yl)methanone | | 167788805 | |
| Z2876442907 | ethyl 2-[[2-(4-methyl-1H-indol-3-yl)ethylamino]methyl]-1,3-thiazole-5-carboxylate | | 167850865 | |
| Z3517967757 | 4-[1-(1-pyrimidin-2-ylethyl)piperidin-3-yl]phenol | | 167949972 | 2817502-85-3 |
| Z3881312504 | 2-bromo-4-[2-[methyl-[2-(1,3-thiazol-2-yl)ethyl]amino]ethyl]phenol | | 167904469 | |
| Z4154032166 | 2,2,2-trifluoro-1-[6-(1,2,3,6-tetrahydropyridin-5-yl)pyridin-2-yl]ethanol | | 167878716 | |
| Z5247692566 | 4-[(3,3-dimethyloxolan-2-yl)methyl]-3-[(1H-indol-3-yl)methyl]morpholine | | | |
| Z5247692629 | 1-(1-bicyclo[1.1.1]pentanyl)-4-[[5-(4-chlorophenyl)-1H-pyrazol-4-yl]methyl]piperazine | | 166358273 | 2728554-00-3 |