# List of Spider-Man enemies in other media

The comic book character Spider-Man has had much media attention due to his popularity as a superhero, as have his villains. Here is a list of his primary villains that have undergone media attention such as in films, televisions, and video games as well as some villains who debuted in the TV series.

## Film

This is a list of Spider-Man enemies that have been in Sam Raimi's Spider-Man film trilogy, Marc Webb's The Amazing Spider-Man films, the Marvel Cinematic Universe (MCU), and Sony's Spider-Man Universe.
The movies in the original trilogy also introduces Dylan Baker as Dr. Curt Connors, the man who in the comics becomes the Lizard, but this transformation never took place during Raimi's tenure as director. Mendel Stromm was portrayed by actor Ron Perkins in Spider-Man, although he did not become a villain while Spider-Man 2 features Daniel Gillies as John Jameson, whose transformation into the Man-Wolf is not depicted in the film. Additionally, the Kingpin was featured prominently in the Mark Steven Johnson film Daredevil, where he was portrayed by Michael Clarke Duncan.
In The Amazing Spider-Man, the Lizard is the villain. Irrfan Khan also portrays the antagonistic Dr. Ratha in that film. In The Amazing Spider-Man 2, Felicity Jones plays Felicia Hardy, the alter ego of Black Cat but her version of Black Cat was never shown.
In Spider-Man: Homecoming, Michael Mando appears as Mac Gargan, but did not become Scorpion. In Spider-Man: Far From Home, Jake Gyllenhaal portrays Mysterio, who was originally to be played by Bruce Campbell in Raimi's canceled fourth film.
Additionally, although the character has not appeared in an MCU film yet, Vincent D'Onofrio portrays the Kingpin in Marvel Television's Netflix series Daredevil and the Disney+ series Hawkeye, Echo, and Daredevil: Born Again.
Live-action films
| Villain | Film | Actor |
| Janice Lincoln Beetle | Spider-Man: Far From Home | Claire Rushbrook |
| Felicia Hardy Black Cat | The Amazing Spider-Man 2 | Felicity Jones |
| Dennis Carradine Burglar | Spider-Man (2002) Spider-Man 3The Amazing Spider-Man (2012) | Michael Papajohn Leif Gantvoort |
| Calypso Ezili Calypso | Kraven the Hunter (2023) | Ariana DeBose |
| Cletus Kasady Carnage | Venom (2018)Venom: Let There Be Carnage | Woody HarrelsonJack Bandeira Woody Harrelson |
| Dmitri Smerdyakov Chameleon | Spider-Man: Far From HomeKraven the Hunter (2023) | Numan AcarFred Hechinger |
| Randy Vale Darter | Spider-Man: Homecoming | Christopher Berry |
| Dr. Otto Octavius Doctor Octopus | Spider-Man 2 Spider-Man: No Way Home | Alfred Molina |
| Donald Menken | The Amazing Spider-Man 2 | Colm Feore |
| Max Dillon Electro | The Amazing Spider-Man 2 Spider-Man: No Way Home | Jamie Foxx |
| Karl Fiers Finisher | The Amazing Spider-Man 2 | Bill Heck |
| Kris Keating Foreigner | Kraven the Hunter (2023) | Christopher Abbott |
| Gustav Fiers Gentleman | The Amazing Spider-Man (2012) The Amazing Spider-Man 2 | Michael Massee |
| Harry Osborn Green Goblin | Spider-Man (2002) Spider-Man 2 Spider-Man 3The Amazing Spider-Man 2 | James Franco Dane DeHaan |
| Norman Osborn Green Goblin | Spider-Man (2002) Spider-Man 2 Spider-Man 3 Spider-Man: No Way HomeThe Amazing Spider-Man 2 | Willem Dafoe Chris Cooper |
| Ned Leeds Hobgoblin | Spider-Man: Homecoming Avengers: Infinity War Avengers: Endgame Spider-Man: Far From Home Spider-Man: No Way Home | Jacob Batalon |
| Wilson Fisk Kingpin | The Trial of the Incredible HulkDaredevil (film) Daredevil (TV series) Hawkeye (TV series) Echo (TV series) Daredevil: Born Again | John Rhys-DaviesMichael Clarke Duncan Vincent D'Onofrio |
| Knull | Venom: The Last Dance | Andy Serkis |
| Sergei Kravinoff Kraven the Hunter | Kraven the Hunter (2023) | Aaron Taylor-Johnson |
| Dr. Curt Connors Lizard | Spider-Man 2 Spider-Man 3The Amazing Spider-Man (2012) Spider-Man: No Way Home | Dylan Baker Rhys Ifans |
| John Jameson Man-Wolf | Spider-Man 2Venom (2018) | Daniel GilliesChris O'Hara |
| Dr. Michael Morbius Morbius, the Living Vampire | Blade (1998)Morbius (2022) | Stephen NorringtonJared Leto |
| Quentin Beck Mysterio | Spider-Man: Far From Home Spider-Man: No Way Home | Jake Gyllenhaal |
| Leland Owlsley Owl | Daredevil (TV series) | Bob Gunton |
| Aaron Davis Prowler | Spider-Man: Homecoming | Donald Glover |
| Frank Castle Punisher | The Punisher (1989)The Punisher (2004)Punisher: War ZoneDaredevil (TV series) The Punisher (TV series) Daredevil: Born Again | Dolph LundgrenThomas JaneRay StevensonJon Bernthal |
| Dr. Ashley Kafka Queen Goblin | The Amazing Spider-Man 2 | Marton Csokas |
| Aleksei Sytsevich Rhino | The Amazing Spider-Man 2Kraven the Hunter (2023) | Paul GiamattiAlessandro Nivola |
| Carlton Drake Riot | Venom (2018) | Riz Ahmed |
| Professor Mendel Stromm Robot-Master | Spider-Man (2002)Superhero Movie (2008) | Ron PerkinsBrent Spiner |
| Flint Marko Sandman | Spider-Man 3 Spider-Man: No Way Home | Thomas Haden Church |
| Mac Gargan Scorpion | Spider-Man: Homecoming | Michael Mando |
| Liz Allan Screwball | Spider-Man (2002)Spider-Man: Homecoming | Sally LivingstoneLaura Harrier |
| Anne Weying She-Venom | Venom (2018) Venom: Let There Be Carnage | Michelle Williams |
| Herman Schultz Shocker II | Spider-Man: Homecoming | Bokeem Woodbine |
| Jackson Brice Shocker I | Spider-Man: Homecoming | Logan Marshall Green |
| Frances Barrison Shriek | Venom: Let There Be Carnage | Naomie Harris |
| Antonia Dreykov Taskmaster | Black Widow Thunderbolts* | Olga Kurylenko |
| Phineas Mason Tinkerer | Spider-Man: Homecoming | Michael Chernus |
| Patrick Mulligan Toxin | Venom: Let There Be Carnage Venom: The Last Dance | Sean Delaney Stephen Graham |
| Alistair Smythe Ultimate Spider-Slayer | The Amazing Spider-Man 2 | B. J. Novak |
| Eddie Brock Venom | Spider-Man 3Venom (2018) Venom: Let There Be Carnage Spider-Man: No Way Home Venom: The Last Dance | Topher GraceTom Hardy |
| Adrian Toomes Vulture | Spider-Man: Homecoming Morbius (2022) | Michael Keaton |
Animated films
| Villain | Film | Actor |
| Richard Fisk Blood Rose | Spider-Man: Into the Spider-Verse | Basement photo cameo |
| Olivia Octavius Doctor Octopus | Spider-Man: Into the Spider-Verse | Kathryn Hahn |
| Otto Octavius Doctor Octopus | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameo |
| Norman Osborn Green Goblin | Spider-Man: Into the Spider-Verse | Jorma Taccone |
| Norman Osborn Green Goblin | Spider-Man: Across the Spider-Verse | non-speaking cameo |
| unnamed female Pirate Doctor Octopus | Spider-Man: Across the Spider-Verse | non-speaking cameo |
| Otto Octavius The Superior Spider-Man | Spider-Man: Across the Spider-Verse | non-speaking cameo |
| Daniel Brito Fancy Dan | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameos |
| Joseph Martello Hammerhead | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameos |
| Wilson Fisk Kingpin | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | Liev Schreiber |
| Dmitri Smerdyakov Chameleon | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameo |
| Peter Parker Lizard | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameoJack Quaid |
| Jackson Brice Montana | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameo |
| Raymond Bloch Ox | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | Basement photo cameo |
| Aaron Davis Prowler | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | Mahershala Ali |
| Maximus Gargan Scorpion | Spider-Man: Into the Spider-Verse | Joaquín Cosío |
| Herman Schultz Shocker | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | Earth-1610B, Captured by Spider-Society and Earth-42 |
| Jonathan Ohnn Spot | Spider-Man: Into the Spider-Verse Spider-Man: Across the Spider-Verse | non-speaking cameoJason Schwartzman |
| Lonnie Lincoln Tombstone | Spider-Man: Into the Spider-Verse | Marvin "Krondon" Jones III |
| Adrian Toomes Vulture | Spider-Man: Across the Spider-Verse | Jorma Taccone |

## Television

A number of Spider-Man villains have made appearances in Spider-Man television series or other Marvel Comics related shows mostly in animation. Also, in Wolverine and the X-Men, there was a character that closely resembles Shadrac. Here is a listing in alphabetical order.
| Villain | Television | Actor |
| Anti-Venom Symbiote | Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Matt Lanter (Harry Osborn)Connor Andrade (Groot) |
| Beetle Abner Jenkins | Spider-Man and His Amazing FriendsIron Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Christopher CollinsJohn ReillySteven BlumFred Tatasciore |
| Boomerang Fred Myers | The Marvel Super HeroesThe Avengers: United They StandUltimate Spider-Man (TV series) | Ed McNamaraRob CowanRob Paulsen |
| Big Man Frederick Foswell | Spider-Man (1967 TV series)The Spectacular Spider-Man (TV series) | N/A (alter ego only)James Arnold Taylor (alter ego only) |
| Big Wheel Jackson Wheele | Spider-Man (1994 TV series)Spider-Man (2017 TV series) | Michael Des BarresMentioned |
| Black Cat Felicia Hardy | Spider-Man (1981 TV series)Spider-Man (1994 TV series) (reformed) The Spectacular Spider-Man (TV series)Spider-Man (2017 TV series)Spidey and His Amazing Friends | Morgan LoftingJennifer HaleTricia HelferGrey GriffinJaiden Klein |
| Burglar | Spider-Man (1967 TV series) Spider-Man (1981 TV series) Spider-Man and His Amazing Friends Spider-Man (1994 TV series) Spider-Man UnlimitedThe Spectacular Spider-Man (TV series) Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | N/A N/A (show theme)Jim Cummings James RemarN/ABenjamin Diskin |
| Calypso Calypso Ezili | Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series) | Susan BeaubanAngela Bryant |
| Carnage Cletus Kasady | Spider-Man (1994 TV series)Spider-Man UnlimitedThe Spectacular Spider-Man (TV series) | Scott CleverdonMichael DonovanN/A (alter ego only) |
| Carnage Symbiote | Ultimate Spider-Man (TV series) Guardians of the Galaxy (TV series) | Dee Bradley Baker (Spider-Man and Doc Ock) Fred Tatasciore (Hulk) Tara Strong (Spider-Woman)Isaac C. Singleton Jr. (Thanos) |
| Chameleon Dmitri Smerdyakov | The Marvel Super HeroesSpider-Man (1981 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)The Spectacular Spider-Man (TV series)Spider-Man (2017 TV series)Your Friendly Neighborhood Spider-Man | Tom HarveyJohn H. MayerHans ConriedJim CummingsSteven BlumPatton OswaltRoger Craig Smith |
| Clash Clayton Cole | Spider-Man (2017 TV series) | Yuri Lowenthal |
| Doctor Octopus Otto Octavius | Spider-Man (1967 TV series)Spider-Man (1981 TV series)The Incredible Hulk (1982 TV series) Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Spider-Man UnlimitedRobot ChickenThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series) Hulk and the Agents of S.M.A.S.H. Lego Marvel Super Heroes: Maximum OverloadMarvel Disk Wars: The AvengersSpider-Man (2017 TV series) (reformed)Marvel Super Hero AdventuresYour Friendly Neighborhood Spider-Man | Vernon ChapmanStan JonesMichael Bell Efrem Zimbalist Jr.N/ASeth GreenPeter MacNicolTom Kenny Dai MatsumotoScott MenvilleLuc RoderiqueHugh Dancy |
| Dracula Vlad Dracula | Spider-Woman (TV series)Spider-Man and His Amazing FriendsThe Super Hero Squad ShowUltimate Spider-Man (TV series) Hulk and the Agents of S.M.A.S.H. Avengers Assemble (TV series) | N/AG. Stanley JonesDave BoatCorey Burton |
| Electro Francine Frye | Spider-Man (2017 TV series) | Daisy Lightfoot |
| Electro Francine Frye | Spidey and His Amazing Friends | Stephanie Lemelin |
| Electro Max Dillon | The Marvel Super HeroesSpider-Man (1967 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Spider-Man UnlimitedSpider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Marvel Super Hero Adventures | N/ATom HarveyAllan MelvinPhilip ProctorDale Wilson (Counter Earth version)Ethan EmbryCrispin FreemanChristopher Daniel BarnesIan James Corlett |
| Enforcers | Spider-Man (1967 TV series) Ox CowboyThe Spectacular Spider-Man (TV series) Montana/Shocker Ox Fancy Dan/RicochetUltimate Spider-Man (TV series) Montana Ox Fancy Dan | N/A N/A Jeff Bennett Clancy Brown, Danny Trejo Phil LaMarr Steven Weber Mark Hamill Troy Baker |
| Green Goblin Harry Osborn | Spider-Man (1994 TV series)Spider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series)Your Friendly Neighborhood Spider-Man | Gary ImhoffIan Ziering (alter ego only)James Arnold Taylor (alter ego only)Matt Lanter (alter ego only)Max Mittelman (alter ego only)Zeno Robinson (alter ego only) |
| Green Goblin Norman Osborn | Spider-Man (1967 TV series)Spider-Man (1981 TV series) Spider-Man (1994 TV series)Spider-Man and His Amazing FriendsSpider-Man UnlimitedThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Marvel Disk Wars: The AvengersMarvel Future AvengersSpider-Man (2017 TV series) Lego Marvel Spider-Man: Vexed by VenomMarvel Super Hero AdventuresSpidey and His Amazing FriendsYour Friendly Neighborhood Spider-Man | Len CarlsonNeil Ross Dennis MarksRino Romano (Counter Earth version)Alan Rachins, Steve BlumSteven WeberYusuke NumataDave WittenbergJosh Keaton Sam VincentJ. P. KarliakColman Domingo (alter ego only) |
| Grizzly Maxwell Markham | Ultimate Spider-Man | John DiMaggio |
| Hammerhead Joseph Martello | Spider-Man (1981 TV series)Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | William BoyettNicky BlairJohn DiMaggioJon Polito (Marvel Noir version)Jim Cummings |
| Hippo ? | Spider-Man (2017 TV series) | Zack Shada |
| Hobgoblin Harry Osborn | Spider-Man (2017 TV series) | Max Mittelman |
| Hobgoblin Jason Macendale | Spider-Man (1994 TV series) | Mark Hamill |
| Hobgoblin Roderick Kingsley | The Spectacular Spider-Man (TV series)Marvel Super Hero Adventures | N/A (alter ego only)Andrew Francis |
| Human Fly Richard Deacon | Spider-Man and His Amazing Friends | N/A |
| Hydro-Man Morris Bench | Spider-Man (1994 TV series)Fantastic Four (1994 TV series)The Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series) | Rob PaulsenBrad GarrettBill Fagerbakke (alter ego only)James Arnold Taylor |
| Jackal Miles Warren | Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series) | Jonathan Harris (alter ego only)Brian George (alter ego only) |
| Jackal Raymond Warren | Spider-Man (2017 TV series) | John DiMaggio |
| Jack O'Lantern ? | Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Drake BellBooboo Stewart |
| Kangaroo Brian Hibbs | Ultimate Spider-Man (TV series) | N/A |
| Kangaroo Frank Oliver | X-Men (TV series) | N/A |
| Kingpin Wilson Fisk | Spider-Man (1967 TV series)Spider-Woman (TV series)Spider-Man (1981 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Spider-Man: The New Animated SeriesYour Friendly Neighborhood Spider-Man | Tom HarveyN/AStan JonesWalker EdmistonRoscoe Lee BrowneMichael Clarke DuncanVincent D'Onofrio |
| Kraven the Hunter Sergei Kravinoff | The Marvel Super HeroesSpider-Man (1981 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Spider-Man UnlimitedSpider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) Avengers Assemble (TV series) | Chris WigginsJack DeLeonRobert RidgelyGregg BergerPaul Dobson (Counter Earth version)Michael DornEric VesbitDiedrich BaderTroy Baker |
| Lady Octopus Carolyn Trainor | Spider-Man (2017 TV series)Spidey and His Amazing Friends | Kari WahlgrenKelly Ohanian |
| Living Brain | Spider-Man (2017 TV series) | Scott Menville |
| Lizard Carla Connors | Your Friendly Neighborhood Spider-Man | Zehra Fazal |
| Lizard Curt Connors | Spider-Man (1967 TV series)Spider-Man (1981 TV series)Spider-Man (1994 TV series)Spider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series) Marvel Disk Wars: The AvengersSpider-Man (2017 TV series)Spidey and His Amazing Friends | Gillie FenwickN/AJoseph CampanellaRob ZombieDee Bradley BakerTom Kenny Dee Bradley BakerYusuke HandaYuri LowenthalBumper Robinson |
| Mania Symbiote | Spider-Man (2017 TV series) | Carla Jeffery |
| Man Mountain Marko Michael Marko | Spider-Man (1981 TV series) | Jack Angel |
| Man-Wolf John Jameson | Spider-Man (1994 TV series)Spider-Man UnlimitedThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Michael Horton (alter ego only)John Payne, Scott McNeilDaran Norris (alter ego only)Nolan NorthJosh Keaton |
| Mister Negative Martin Li | Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Keone Young (Marvel Noir version)Eric Bauza |
| Molten Man Mark Raxton | The Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Eric LopezJames Arnold TaylorImari Williams |
| Morbius the Living Vampire Michael Morbius | Spider-Man (1994 TV series)Ultimate Spider-Man (TV series) | Nick JamesonBenjamin Diskin |
| Mysterio Francis Beck | Ultimate Spider-Man (TV series) | Mary Kate Wiles |
| Mysterio Quentin Beck | Spider-Man (1967 TV series)Spider-Man (1981 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)The Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series)What If...? (TV series) | Chris WigginsMichael RyePeter CullenGregg BergerXander BerkeleyPaul ScheerCrispin FreemanAlejandro Saab |
| Overdrive ? | Spider-Man (2017 TV series) | Ryan Blaney |
| Panda-Mania ? | Spider-Man (2017 TV series) | Teala Dunn |
| Prowler Hobie Brown | Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series)Spider-Man (2017 TV series) | Tim RussCharles Duckworth (alter ego only)Nathaniel J. Potvin |
| Puma Thomas Fireheart | Spider-Man (2017 TV series) | N/A |
| Regent Augustus Roman | Spider-Man (2017 TV series) | Imari Williams |
| Rhino Aleksei Sytsevich | Spider-Man (1967 TV series)Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series) Spider-Man (2017 TV series)Marvel Super Hero AdventuresSpidey and His Amazing FriendsYour Friendly Neighborhood Spider-Man | Ed McNameraDon StarkClancy BrownDaryl Sabara Max MittelmanMatthew MercerN/AJustin ShenkarowTBA |
| Richard Fisk | Spider-Man (1994 TV series) | Nick Jameson |
| Sandgirl Keemia Alvarado | Spider-Man (2017 TV series) | Sofia Carson |
| Sandman William Baker | Spider-Man (1967 TV series)Fantastic Four (1978 TV series)Spider-Man (1981 TV series)Spider-Man and His Amazing FriendsThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series)Spidey and His Amazing Friends | Tom HarveyNANeil RossChristopher CollinsJohn DiMaggioDee Bradley BakerTravis WillinghamThomas F. Wilson |
| Scorn Symbiote | Spider-Man (2017 TV series) | Kylee Russell |
| Scorpion Mac Gargan | Spider-Man (1967 TV series)Spider-Man and His Amazing FriendsSpider-Man (1994 TV series) Spider-Man (2017 TV series)Your Friendly Neighborhood Spider-Man | Carl BanasN/AMartin Landau Richard MollJason SpisakJonathan Medina |
| Scorpion ? | Ultimate Spider-Man (TV series) | Dante Basco (identity only) Eric Bauza (identity only) |
| Scream Symbiote | Spider-Man (2017 TV series) | Meg Donnelly |
| Shocker Herman Schultz | Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | John StephensonJim CummingsTroy BakerCameron Boyce |
| Shocker Jackson Brice | The Spectacular Spider-Man (TV series) | Jeff Bennett (identity only) |
| Shriek Frances Barrison | Ultimate Spider-Man (TV series) | Ashley Eckstein |
| Silvermane Silvio Manfredi | Spider-Man (1981 TV series)Spider-Man (1994 TV series) The Spectacular Spider-Man (TV series)Spider-Man (2017 TV series) | Paul WinchellJeff Corey Townsend Coleman (young man) Matthew McCurly (child)Miguel FerrerNolan North |
| Silver Sable Silver Sablinova | Spider-Man (1994 TV series)Spider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Spider-Man (2017 TV series) | Mira FurlanVirginia MadsenNikki CoxApril Stewart |
| Slyde Jalome Beacher | Spider-Man (2017 TV series) | Phil LaMarr |
| Spencer Smythe | Spider-Man (1994 TV series)Spider-Man (2017 TV series) | Edward MulhareBenjamin Diskin |
| Spider-Carnage | Spider-Man (1994 TV series) | Christopher Daniel Barnes |
| Spider-Slayer | Spider-Man (1967 TV series) Spider-Man (1994 TV series)Ultimate Spider-Man (TV series) Spider-Man (2017 TV series) | N/A Drake Bell (Kaine) Imari Williams (Bone Spider, Goliath Spider) Roger Craig Smith (Ghost Spider)N/A |
| Spot Jonathan Ohnn | Spider-Man (1994 TV series)Spider-Man (2017 TV series) | Oliver MuirheadCrispin Freeman |
| Stegron Vincent Stegron | Marvel Super Hero Adventures | Mark Oliver |
| Swarm Fritz von Meyer | Spider-Man and His Amazing FriendsMarvel Super Hero Adventures | Al FannIan James Corlett |
| Swarm Jefferson Davis | Spider-Man (2017 TV series) | Alex Désert |
| Swarm Michael Tan | Ultimate Spider-Man (TV series) | Eric Bauza Drake Bell |
| Tarantula Maria Vasquez | Your Friendly Neighborhood Spider-Man | Anairis Quiñones |
| Taskmaster Tony Masters | Ultimate Spider-Man (TV series) Avengers Assemble (TV series) | Clancy Brown |
| Tinkerer Phineas Mason | The Spectacular Spider-Man (TV series)Spider-Man (2017 TV series)Marvel Super Hero Adventures | Thom Adcox-HernandezAaron AbramsMichael Daingerfield |
| Tombstone Lonnie Lincoln | Spider-Man (1994 TV series)The Spectacular Spider-Man (TV series) Your Friendly Neighborhood Spider-Man | Dorian HarewoodKeith David Kevin Michael RichardsonEugene Byrd (alter ego only) |
| Ultimate Spider-Slayer Alistair Smythe | Spider-Man (1994 TV series)Spider-Man (2017 TV series) | Maxwell CaulfieldJason Spisak |
| Venom Eddie Brock | Spider-Man (1994 TV series)Spider-Man UnlimitedThe Spectacular Spider-Man (TV series)Lego Marvel Super Heroes: Maximum OverloadSpider-Man (2017 TV series) | Hank AzariaBrian DrummondBenjamin DiskinDee Bradley BakerBen Pronsky |
| Venom Flash Thompson | Spider-Man and His Amazing FriendsSpider-Man (1994 TV series)Spider-Man: The New Animated SeriesThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) | Frank Welker (alter ego only)Patrick Labyorteaux (alter ego only)Devon Sawa (alter ego only)Joshua LeBar (alter ego only)Matt LanterBenjamin Diskin |
| Venom Symbiote | Ultimate Spider-Man (TV series) Hulk and the Agents of S.M.A.S.H. Avengers Assemble (TV series) Marvel Disk Wars: The AvengersGuardians of the Galaxy (TV series) Spider-Man (2017 TV series) Marvel Super Hero AdventuresYour Friendly Neighborhood Spider-Man | Matt Lanter (Harry Osborn) Steven Weber (Green Goblin) Benjamin Diskin (Skaar) Eliza Dushku (She-Hulk) Seth Green (A-Bomb) Clancy Brown (Red Hulk) Fred Tatasciore (Hulk) Corey Burton (Dracula)N/AN/A Sofia Wylie (Ironheart) Aubrey Joseph (Cloak) Olivia Holt (Dagger) Connor Andrade (Groot) Ki Hong Lee (Amadeus Cho) Liam O'Brien (Doctor Strange) Mick Wingert (Iron Man) Roger Craig Smith (Captain America) Grey Griffin (Captain Marvel)N/AKellen Goff |
| Vulture Adrian Toomes | Spider-Man (1967 TV series)Spider-Man (1981 TV series)Spider-Man (1994 TV series)Spider-Man UnlimitedThe Spectacular Spider-Man (TV series)Ultimate Spider-Man (TV series)Spider-Man (2017 TV series) Avengers Assemble (TV series) | Gillie FenwickDon MessickEddie AlbertScott McNeil (Counter Earth version)Robert EnglundTom KennyAlastair Duncan |
| White Rabbit Lorina Dodson | Your Friendly Neighborhood Spider-Man | TBA |

### Sinister Six

A few of Spider-Man villains in other media have joined the group Sinister Six (or Insidious Six in Spider-Man: The Animated Series and Sinister Seven or Superior Sinister Six in Ultimate Spider-Man) to take down Spider-Man just like in the comics. Here is a list of villains who have joined. The numbers beside the supervillain with the parentheses in between them stand for their first meeting and second meeting and so on. There has never been a proper depiction of the original Sinister Six (Doctor Octopus, Mysterio, Vulture, Sandman, Kraven and Electro), but in most franchises, all of the members appear, mainly without joining.
| Show | Members | Leader |
| Spider-Man (1994 TV series) This version features several original members, though not all. This group is organized by Kingpin, though he is not a member. | Chameleon (1st) (2nd) Doctor Octopus (1st) (2nd) Mysterio (1st) Rhino (1st) (2nd) Scorpion (1st) (2nd) Shocker (1st) (2nd) Vulture (2nd) | Kingpin |
| The Spectacular Spider-Man This series is the most faithful to the source material, with the only unoriginal members being Shocker and Rhino. | Doctor Octopus (1st) (2nd) Electro (1st) (2nd) Kraven (2nd) Mysterio (2nd) Rhino (1st) (2nd) Sandman (1st) (2nd) Shocker (1st) Vulture (1st) (2nd) | Doctor Octopus |
| Ultimate Spider-Man This version holds the record for most changed members. It mainly features new characters who were not depicted in the source material. | Beetle (1st) Crossbones (as Lizard) (4th) Doctor Octopus (1st) (2nd) (3rd) (4th) Electro (1st) (2nd) (3rd) Hydro-Man (3rd) Kraven (1st) (2nd) (3rd) (4th) Lizard (1st) (2nd) Rhino (1st) (2nd) (3rd) (4th) Scarlet Spider (3rd) Scorpion (2nd) (4th) Ultimate Green Goblin (3rd) Vulture (4th) | Doctor Octopus |
| Spider-Man (2017 TV series) This version is the least faithful to the source material. All members (except Doctor Octopus, the leader) are possessed. | Alistair Smythe Doctor Octopus Rhino Spider-Man Steel Spider Vulture | Doctor Octopus |

## Made-for-TV villains

These villains do not appear in the comics. They were created for various cartoon series. Among them are:

### Spider-Man (1967)

* Baron von Rantenraven (voiced by Tom Harvey) - A German pilot who commanded Sky Harbor, which he used to invade New York with World War I biplanes. He uses paralyzing devices.
* Blackwell the Magician (voiced by Chris Wiggins) - Not a proper villain, but a powerful stage magician who tries to get Spider-Man's help to prevent the old Castle theater from being torn down, with former actors Emily Thorndike and James Booth. Later, the Green Goblin steals some of his magical equipment, but Blackwell helps Spider-Man defeat him.
* Blotto - A monster brought to life by Clive's "Spirit Scope" for getting revenge on the world. It starts consuming the city, but it is destroyed after being exposed to the Spirit Scope for a second time.
* Bolton (voiced by Len Carlson) - A giant Martian warrior who can throw thunderbolts and was sent to invade Earth. He was freed from Spider-Man's webbing by the Boomer, who then led Bolton to the "Gold Bullion Building", before he is accidentally sent away from Earth by one of his own thunderbolts. He is not to be confused with Thor.
* Boomer (voiced by Chris Wiggins) - A crook who used explosives to rob banks with his partner the Borer due to lightning covering the sound. He commanded Bolton after freeing them, but after their defeat Spider-Man knocks him out.
* Charles Cameo (voiced by Claude Ray in the first appearance, Carl Banas in the second appearance) - A former actor who used disguises to commit crimes. He once impersonated the Prime Minister of Rutania to steal charity money and later impersonated well-known figures and finally Spider-Man to steal art treasures, but both times was exposed.
** Brutus - Cameo's thuggish getaway driver.
* Carol - A spider-like alien who stole scientific equipment to help save her people.
* Clive (voiced by Tom Harvey) - A movie producer who planned revenge on the movie critics and audiences by creating the monster Blotto with his "Spirit Scope" while hiding in a power plant.
** Collin - The dwarfish assistant of Clive. He is accidentally paralyzed by Clive's "Spirit Scope", but the Mayor later mentions he responded to treatment.
* Desperado (voiced by Bernard Cowan) - A cowboy-themed thief armed with hypnotic guns. He flew around on a robotic horse equipped with a helicopter-like rotor.
* De Vargas - A Spanish conquistador who ruled a golden Aztec city in the Andes (it is never explained what the Aztecs were doing in the Andes).
* Dr. Atlantean (voiced by Tom Harvey) - A scientist from Atlantis who brought Manhattan underwater as part of a plan to help the Atlanteans invade. He is a redrawn version of the Master Technician/Radiation Specialist.
* Dr. Cool - A diamond thief who put Spider-Man in a freezer that was somehow able to be set to absolute zero.
* Dr. Dumpty - Full name Dr. Humperdink Dumpty; a thief who stole the jewels of actor Rachel Welles when he attacked a parade. He utilized a small variety of balloon-themed weapons.
* Dr. Genie - An evil female genie disguised as a woman named "Melissa Genie".
* Dr. Magneto (voiced by Bernard Cowan) - Real name Dr. Matto Magneto (pronounced mag-net-o), he is a scientist armed with a gun that could magnetize and de-magnetize metals and non-metals. He planned revenge upon the world for refusing to induct him into the Science Hall of Fame. Using anti-magnetic webbing, Spider-Man defeated Dr. Magneto.
* Dr. Manta (voiced by Carl Banas) - Actually a Rocket Robin Hood villain. He used giant, mechanical beetles and other monsters (all controlled by playing an organ) to enslave an island's inhabitants and planned to use them to mine a mineral which would give him great power.
* Dr. Noah Boddy (voiced by Henry Ramer) - A brilliant scientist who has somehow found a way to make himself invisible. In his first appearance, he took revenge on J. Jonah Jameson for ridiculing his theories of invisibility. In the second appearance, he broke Electro, the Green Goblin, and the Vulture out of jail to take out Spider-Man. Spider-Man makes them fight among themselves using ventriloquism, then webs up Boddy, who is then jailed.
* Dr. Vespasian - A criminal scientist who developed a drinkable invisibility serum that he tested on himself and his dog Brutus and who tried to get the cooperation of the city's major criminals by getting rid of Spider-Man, before being captured in ice cream by Spider-Man.
* Dr. Von Schlick (voiced by Bernard Cowan) - An evil scientist who wore a rubber, non-stick costume with petroleum-based bubbles emitted from his fingers. Spider-Man had to use a special webbing to stop him.
* Dr. Zap - An electricity-powered scientist who kidnapped Dr. Irving Caldwell to learn the secrets of his levitation helmet.
* Fakir (voiced by Paul Soles) - An Arabian fakir whose flute could move objects, cast illusions, and control alligators.
* Fiddler (voiced by Paul Kligman) - Otherwise only known as "Otto", Fiddler is a man whose violin was capable of concussive blasts and disintegrating objects. He was angry that rock music was overcoming classical music.
* Gator - An alligator that was given superhuman intelligence by Curt Conner. Its appearance was made from recycled footage of the Lizard's episode.
* Harley Clivendon (voiced by Chris Wiggins) - An Australian game hunter who once hypnotized J. Jonah Jameson with an idol so that he could steal their money with the help of an Aborigine. He later tried to find the Fountain of Youth.
* Human Fly Twins - Real names Stan Patterson (voiced by Len Carlson in the first appearance, Alfie Scopp in the second appearance) and Lee Patterson (voiced by Paul Kligman in the first appearance, Henry Ramer in the second appearance), they are former circus performers who robbed people with their ability to scale walls. They once impersonated Spider-Man. Not to be confused with the Human Fly found in the mainstream comics.
* Infinata (voiced by Chris Wiggins) - Actually a Rocket Robin Hood villain. Infinata is from Dementia Five in the Fifth Dimension. He attempted to steal the Library of Gorth from a dying scientist who came from the destroyed planet Gorth, but Spider-Man discovered all of his power is based on fear.
* Master Technician/Radiation Specialist - A mad scientist who took over Manhattan's new and only nuclear power plant and uses a special ray in it to lift Manhattan into the clouds unless the city met his demands like amnesty from arrest and the right to make his own power plant. He had a radiation gun, which gave Spider-Man a disadvantage. In his next appearance, he is released from prison and uses radiation that takes over nearly all of the city's minds. In "Swing City," he is named the Master Technician. In "Specialists and Slaves," he is the Radiation Specialist. The episode "Up From Nowhere" features Dr. Atlantean who is a slightly redrawn Master Technician.
* Master Vine (voiced by Tom Harvey) - The leader of a prehistoric race of plant people that lives off of radium energy. In a redone appearance, the people used a machine that cools the environment.
* Micro Man - Real name Professor Pretorius, a diabolical scientist who created a light bulb that could shrink him to a small size and planned to destroy New York with a nuclear weapon he called "The Kingdom Come Device" after breaking out of prison. The name "Micro Man" comes from the title of the episode, and is not used in the episode itself.
* Miss Trubble - A middle-aged woman with a chest that enabled her to summon living statue versions of Greek mythological gods, goddesses and creatures.
* Mole (voiced by Tom Harvey) - Leader of the Molemen who led his kind into stealing buildings. His appearance used footage of Mugs Riley's Moleman disguise.
* Mugs Reilly (voiced by Tom Harvey) - A criminal who escaped from jail and discovered an underground society of Molemen. He used them to steal entire banks while disguised as their leader, but was unmasked by Spider-Man.
* Parafino (voiced by Len Carlson) - Owner of Parafino's Wax Museum, he is able to create living wax sculptures and trap people in suspended animation. He once used wax mannequins of Blackbeard, Jesse James (voiced by Jack Mather), and the Executioner of Paris (voiced by Max Ferguson) to commit crimes.
* Pardo (voiced by Gillie Fenwick) - A strange-looking man who could turn into an enormous black house cat composed of "pure energy" with hypnotic (and possibly teleporting) vision. When the black cat is electrocuted, all that is left is Pardo's clothes.
* Phantom (voiced by Max Ferguson in the first appearance, Alfie Scopp in the second appearance) - Some sort of inventor, he appeared in "The Fifth Avenue Phantom" and "The Dark Terrors". He used a device that shrank valuables as well as android women who masqueraded as department store mannequins. In his second appearance, he used a Shadow-Scope to create shadow monsters to commit crimes.
* Plotter (voiced by Gillie Fenwick) - The Plotter is a criminal mastermind who hires Ox and Cowboy to steal a blueprint for a missile and has a hideout of sophisticated technology.
* Plutonians - Not proper villains, but large ice beings from Pluto with freezing powers who attempt to kidnap Dr. Smartyr so that they can use his space warp-drive to leave Earth. After Spider-Man hears this story from the Plutonian Leader (voiced by Bernard Cowan), Spider-Man and Dr. Smartyr help them leave Earth at the end of the episode.
* Ponce de León - A centuries-old Spanish conquistador who found the Fountain of Youth and kidnapped Dr. Conner to prevent it from being discovered, although his cannon accidentally destroys it and he disappears. Never actually named, Dr. Conner and Spider-Man say the character just may have been Ponce de Leon around the end of the episode.
* Red Dog Melvin - A criminal who was assisted by Parafino.
* Robot - A huge metal-eating robot; it is unexplained where it came from. Spider-Man defeated it by causing it to fall into the water and short-circuit.
* Scarf - A thief who projected psychedelic images into the sky and stole things during the confusion.
* Scarlet Sorcerer (voiced by Carl Banas) - An ancient Egyptian sorcerer named Kotep who was defeated by his opponent Brazman and placed in suspended animation until a professor at Peter Parker's school used an incantation to awaken him 7,000 years later. He was followed by an army of demons who said they would only obey him if he defeated Spider-Man. Without his scepter, the Scarlet Sorcerer loses his power. When Spider-Man breaks it, he goes back into the depths of time.
* Shakespeare - A gentleman thief whose gang dressed up in gorilla suits after some were let loose at a zoo to steal diamonds.
* Sir Galahad - A thief dressed in a full suit of armor who rode a motorcycle and armed himself with an electrified lance.
* Skymaster - A criminal that hated all "ground-dwellers", riding in his blimp.
* Snowman - A snowman brought to life by a chemical reaction and electrical charge. Spider-Man defeated the Snowman by electrocuting him. He is only briefly named the "Snow Master" by J. Jonah Jameson in the closing moments of the episode.
* Super Swami - A swami called Coga with a talent for creating illusions. He was eventually knocked into a river by Spider-Man and jailed.

### Spider-Man (1981 TV series)

* Gadgeteer (voiced by Richard Ramos) - Joshua is an evil and jealous janitor who seeking to gain attention takes on this identity to steal Dr. Norton's shrink ray.
* Nephilia (voiced by Arlin Miller) - A scientist named Dr. Bradley Shaw and his assistant Penny plotted to attain Spider-Man's blood and a DNA sample of a Nephilia spider to duplicate his powers. However, Shaw is transformed into a mutant spider hybrid before Spider-Man cures him.
* Professor Gizmo (voiced by Ron Feinberg) - Professor Gizmo is a master criminal who planned to use Spider-Man to attach an antenna to the large sunken treasure ship, the El Conquistador.
* Sidewinder (voiced by Philip L. Clarke) - Sidewinder is a masked cowboy villain who rides a flying robot horse. He leads a gang of cowboys who also ride flying robot horses. Spider-Man managed to defeat Sidewinder and discover that he is Wild Willie Wilson who had pulled the robberies that framed the original owner of the Rodeo Show.
* Stuntman (voiced by Peter Cullen) - Jack Riven was the World's Greatest Stuntman until an accident permanently fused him to a mechanical suit of armor a few years ago. He blames Spider-Man for that. Stuntman has two lackey named Larry and Moe (voiced by Gene Ross and Jack Angel) who help make up the Triangle of Evil.

### Spider-Man and His Amazing Friends (1981)

* Arachnoid (voiced by Dan Gilvezan) - Zoltan is a chemical scientist who creates a Spider Serum that will give him Spider Powers. He impersonates and frames Spider-Man when committing crimes until he mutates into the Arachnoid: a mutant with the torso of a man and a spider's body from the waist down. His assistant Monica gives the Spider Friends the antidote to return Zoltan to normal.
* Buzz Mason - A S.H.I.E.L.D. agent who secretly mind-controlled Lightwave into committing robberies of a device that will enable him to control a satellite called the GUARDSTAR.
* Cyberiad (voiced by Dennis Marks) - Nathan Price was Firestar's boyfriend until an accident caused by an attack by A.I.M. caused him to end up as a cyborg called Cyberiad. He attacked the X-Men Mansion and captured its members one-by-one. His design is based on Fatal Five member Tharok.
* Gamesman - The Gamesman plotted to cause havoc in New York by using the arcade games to hypnotize the teenagers there. He unwittingly caused Francis Byte to become Videoman resulting in Gamesman to manipulate him.
* Lightwave (voiced by Marlene Aragon) - Aurora Dante is Iceman's half-sister who can manipulate and control light. She is an agent of S.H.I.E.L.D. until Buzz Mason mind-controlled her into stealing a device that will allow Buzz to control the GUARDSTAR. Lightwave is based on Aurora and Darkstar.
* Videoman - Electro brought it out of an arcade game to steal components for his Ultra-Transformer, but was defeated by the Spider-Friends. Videoman was released again during a thunderstorm. A teenage video game prodigy named Francis Byte (voiced by Frank Welker) ends up becoming Videoman due to an explosion caused by the Gamesman's plot where Francis learns to become a good superhero. After the Gamesman's defeat, he is now training with the X-Men.

### Spider-Man (1994 TV series)

* Alisha Silvermane (voiced by Leigh-Allyn Baker) - In this series, she is Silvermane's daughter.
* Iceberg (voiced by Lawrence Mandley) - He was a frozen crime lord that works for the Kingpin and that Hobbie Brown used to work for before becoming the Prowler.
* Lizard Warriors - A group of normal lizards in the sewer that were mutated by Curt Connors' DNA that was leaked into the sewers. They began to rever Curt Connors as their father and wanted his Lizard side to lead them. With help from Debra Whitman and Martha Connors, Spider-Man and Mary Jane Watson helped to cure Lizard with a special bomb that also regressed the Lizard Warriors back to their normal forms.
** Monitor (voiced by Rodney Saulsberry) - Member of the Lizard Warriors.
** Gecko (voiced by Roger Kern) - Member of the Lizard Warriors.
** Gila (voiced by Kathy Garver) - Member of the Lizard Warriors. She later helped Spider-Man, Mary Jane Watson, Debra Whitman, and Marth Connors in curing Lizard and returning all Lizard Warriors including herself back to normal.
* Miriam (voiced by Nichelle Nichols) - In this series, she is a Vampire Queen and the mother of Blade.

### Spider-Man: The New Animated Series (2003)

* Dr. Zellner (voiced by Jeffrey Combs) - He developed a drug that would make stupid people intelligent. He tested it on thug twins Jack and Mack and used them to commit crimes.
* The Gaines Twins (voiced by Jeremy Piven and Kathy Griffin) - Roland and Roxanne Gaines are ruthless telepathic twins. They held a vendetta against Kraven the Hunter for killing their parents with a poison (that, ironically, also gave the Twins their powers) and almost manipulated Spider-Man into killing him.
* Piranha - An assassin who, disguised as a European Union member named Harlan Tremain, targeted the Mayor of New York and the President. The Silver Sable attacked him, although Spider-Man thought she was the enemy at first.
* Pterodax - Pterodax is a high-tech mercenary group.
** Sergei (voiced by James Marsters) - Leader of Pterodax.
** Aleksei (voiced by Brendan Connolly) - Member of Pterodax.
** Boris (voiced by Ken Lerner) - Member of Pterodax.
* Shikata (voiced by Gina Gershon) - Shikata is a martial arts expert and swordsman who uses a mystical sword and incantation to stay young. Seeing Spider-Man as a worthy foe, she wanted to fight him to the death. At first Spider-Man refused, but after Shikata threatened Mary Jane, he ended up dueling her. Spider-Man destroyed the sword ending Shikata's prolonged life.
* Talon (voiced by Eve) - Cheyenne Tate is a high-tech thief who was a love interest for Harry Osborn. She is somewhat based on Black Cat.
* Turbo Jet (voiced by Harold Perrineau) - As Turbo Jet, Wyler acts like a modern-day Robin Hood with the stealing from the rich and giving to the poor while wearing a high-tech suit. He is said to be based on Rocket Racer.

### Ultimate Spider-Man (2012)

* Boston Terroriers - A group of lesser Boston criminals stopped by Spider-Man who were given high-tech armor by Steel Spider.
** Plymouth Rocker (voiced by Maurice LaMarche) - A common Boston criminal whose armor enhances his combat skills and gives him superhuman strength and the ability to climb up walls. He is named for Plymouth Rock.
** Salem's Witch (voiced by Misty Lee) - A Boston museum thief who wields anti-gravity disks and laser-shooting bracelets. She is named for the Salem witch trials.
** Slam Adams (voiced by Jeff Bennett) - A Boston robber given high-tech patriot armor by Steel Spider. Slam Adams also wields a shield. He is named for Samuel Adams.
* Wolf Spider (voiced by Christopher Daniel Barnes) - A villainous alternate universe counterpart of Spider-Man.

## Video games

A number of Spider-Man villains have made appearances in Spider-Man video games series or other Marvel Comics related shows mostly in other games. Here is a listing in alphabetical order.
| Villain | Video games | Actor |
| Agony Leslie Gesneria | Spider-Man Unlimited | |
| Anti-Venom Eddie Brock | Spider-Man: Edge of TimeSpider-Man Unlimited | Steve Blum |
| Arcade ? | Spider-Man: Edge of Time | Jim Cummings |
| Beetle Abner Jenkins | Spider-Man: The Animated SeriesSpider-Man: Lethal FoesSpider-Man 2: Enter ElectroUltimate Spider-ManLego Marvel Super Heroes | Daran NorrisTucker SmallwoodSteven Blum |
| Big Wheel Jackson Weele | Spider-Man: Web of ShadowsSpider-Man: Edge of Time | Steve Blum |
| Black Cat Felicia Hardy | Spider-Man (2000)Spider-Man 2Spider-Man: Friend or FoeSpider-Man: Web of ShadowsSpider-Man: Edge of TimeThe Amazing Spider-Man The Amazing Spider-Man 2Spider-Man UnlimitedMarvel's Spider-Man | Jennifer HaleHolly FieldsAudrey WasilewskiTricia HelferKatee SackhoffAli Hillis Tara Strong Erica Lindbeck |
| Black Tarantula Carlos LaMuerto | Spider-Man Unlimited | |
| Boomerang Fred Myers | Ultimate Spider-ManSpider-Man: Shattered Dimensions | Jim Cummings |
| Calypso Calypso Ezili | Spider-Man 2 Spider-Man 3Spider-Man: Shattered Dimensions | Angela V. Shelton Jennifer Hale |
| Carnage Cletus Kasady | Spider-Man (2000)Ultimate Spider-ManSpider-Man: Friend or Foe Spider-Man: Shattered DimensionsThe Amazing Spider-Man 2Spider-Man Unlimited | Dee Bradley BakerWilliam HopeFred Tatasciore David Agranov |
| Carrion Miles Warren's Clone | Spider-Man and Venom: Maximum Carnage | |
| Chameleon Dmitri Smerdyakov | The Amazing Spider-Man 2 | Glenn Steinbaum |
| Demogoblin Demon | Spider-Man and Venom: Maximum CarnageLego Marvel Super HeroesSpider-Man Unlimited | |
| Doctor Octopus Otto Octavius | Spider-Man (2000)Spider-Man 2Spider-Man: Friend or FoeSpider-Man: Edge of TimeSpider-Man UnlimitedMarvel's Spider-Man | Efrem Zimbalist Jr.Alfred MolinaJoe AlaskeyDave B. Mitchell William Salyers |
| Doppelganger Peter Parker's Clone | Spider-Man and Venom: Maximum CarnageSpider-Man Unlimited | |
| Electro Max Dillon | Spider-Man 2: Enter ElectroUltimate Spider-ManSpider-Man 3Spider-Man: Friend or FoeSpider-Man: Web of ShadowsSpider-Man: Shattered Dimensions The Amazing Spider-Man 2 Spider-Man UnlimitedMarvel's Spider-Man | Dee Bradley BakerJames Arnold Taylor David KayeLiam O'BrienThomas F. Wilson Michael Shepperd Liam O'Brien Josh Keaton |
| Green Goblin Harry Osborn | Spider-Man (2002) Spider-Man 2 Spider-Man 3Spider-Man: Friend or FoeThe Amazing Spider-Man 2 Marvel's Spider-Man | Josh Keaton James FrancoJosh KeatonKevin Dorman Nolan NorthScott Porter |
| Green Goblin Norman Osborn | Spider-Man (2002)Ultimate Spider-ManSpider-Man: Friend or Foe Spider-Man: Web of ShadowsSpider-Man: Shattered DimensionsSpider-Man UnlimitedMarvel's Spider-Man | Willem DafoePeter LurieRoger L. Jackson Jim Cummings Mark Rolston |
| Grizzly Max Markham | X-Men Legends II: Rise of Apocalypse | Keith Ferguson |
| Hammerhead Joseph Martello | Spider-Man 2: Enter ElectroSpider-Man: Shattered DimensionsThe Amazing Spider-Man 2Spider-Man UnlimitedMarvel's Spider-Man | Dee Bradley BakerJohn DiMaggioDavid Boat Keith Silverstein |
| Hobgoblin Roderick Kingsley | Spider-Man: Web of ShadowsSpider-Man: Shattered Dimensions | Steve Blum |
| Hydro-Man Morrie Bench | Spider-Man Unlimited | |
| Iguana | The Amazing Spider-ManSpider-Man Unlimited | |
| Jack O'Lantern Jason Macendale | Spider-Man: The Animated SeriesMarvel: Ultimate Alliance 2Marvel: Avengers AllianceSpider-Man Unlimited | |
| Jackal Miles Warren | Spider-Man: Web of Shadows | Greg Baldwin |
| Kingpin Wilson Fisk | Spider-Man 3Spider-Man: Web of ShadowsThe Amazing Spider-Man 2Marvel's Spider-Man | Bob JolesGregg BergerJB BlancTravis Willingham |
| Kraven the Hunter Sergei Kravinoff | Spider-Man (2002)Spider-Man 3Spider-Man: Web of ShadowsSpider-Man: Shattered Dimensions The Amazing Spider-Man 2 Spider-Man Unlimited | Gary Anthony SturgisNeil KaplanDwight SchultzJim Cummings Steve Blum Nolan North |
| Lasher Ramón Hernández | Spider-Man Unlimited | |
| Lizard Curt Connors | Spider-Man (2000) Spider-Man 2: Enter ElectroSpider-Man 2Spider-Man 3Spider-Man: Friend or FoeThe Amazing Spider-Man | Dee Bradley Baker Joe AlaskeyNathan CarlsonRoger L. JacksonSteve Blum |
| Mad Bomber Luke Carlyle | Spider-Man 3 | Neil Ross |
| Man-Wolf John Jameson | Spider-Man 2 | Charles Klausmeyer |
| Menace Lily Hollister | Spider-Man: Edge of Time | Tara Strong |
| Mister Negative Martin Li | Marvel's Spider-Man | Stephen Oyoung |
| Morbius the Living Vampire Michael Morbius | Spider-Man 3Spider-Man Unlimited | Sean Donnellan |
| Morlun | Spider-Man Unlimited | |
| Mysterio Quentin Beck | Spider-Man (2000)Spider-Man 2 Spider-Man: Friend or FoeSpider-Man: Web of ShadowsSpider-Man: Shattered DimensionsSpider-Man Unlimited | Daran NorrisDee Bradley Baker James Arnold TaylorRobin Atkin DownesGreg BaldwinDavid Kaye |
| Nattie, the Piranha | The Amazing Spider-Man | |
| Overdrive James Beverley | Spider-Man: Edge of Time | Kari Wahlgren |
| Phage Carl Mach | Spider-Man Unlimited | |
| Prowler Hobie Brown | Spider-Man: Friend or FoeSpider-Man Unlimited | Chris Gardner |
| Puma Thomas Fireheart | Spider-Man 2 | Dee Bradley Baker |
| Rhino Aleksei Sytsevich | Spider-Man (2000)Spider-Man 2Ultimate Spider-ManSpider-Man 3Spider-Man: Friend or FoeSpider-Man: Web of Shadows Spider-Man: Edge of Time The Amazing Spider-Man The Amazing Spider-Man 2 Marvel's Spider-ManSpider-Man Unlimited | Dee Bradley BakerJohn DiMaggioBob GloubermanSteve BlumJohn DiMaggioFred Tatasciore |
| Riot Trevor Cole | Spider-Man Unlimited | |
| Robot-Master Mendel Stromm | Spider-Man (2002) | Peter Lurie |
| Sandman William Baker | Spider-Man 2: Enter ElectroSpider-Man 3 Spider-Man: Friend or FoeSpider-Man: Web of ShadowsSpider-Man: Shattered DimensionsSpider-Man Unlimited | Daran NorrisThomas Haden ChurchFred Tatasciore Dimitri Diatchenko |
| Scorpion Mac Gargan | Spider-Man (2000)Spider-Man (2002)Spider-Man 3Spider-Man: Friend or FoeSpider-Man: Shattered DimensionsThe Amazing Spider-ManSpider-Man UnlimitedMarvel's Spider-Man | Daran NorrisMike McCollDee Bradley BakerFred TatascioreJohn Kassir Jason Spisak |
| Scream Donna Diego | Spider-Man Unlimited | |
| Screwball Liz Allan | Marvel's Spider-Man | Stephanie Lemelin |
| She-Venom Anne Weying | Spider-Man Unlimited | |
| Shocker Herman Schultz | Spider-Man 2: Enter ElectroSpider-Man (2002) Spider-Man 2Ultimate Spider-ManSpider-Man: Web of ShadowsSpider-Man: Edge of TimeThe Amazing Spider-Man 2Marvel's Spider-Man | Daran NorrisMichael Beattie Brian GeorgeLiam O'BrienSteve BlumRyan AlosioDave B. Mitchell |
| Shriek Frances Barrison | Spider-Man and Venom: Maximum CarnageSpider-Man: Mysterio's MenaceSpider-Man 3 | Courtenay Taylor |
| Silvermane Silvio Manfredi | Spider-Man: Shattered Dimensions | Steve Blum |
| Silver Sable Silver Sablinova | Ultimate Spider-Man Spider-Man: Friend or Foe Spider-Man: Shattered DimensionsSpider-Man UnlimitedMarvel's Spider-Man | Jennifer Hale Nichole Elise |
| Spencer Smythe | Spider-Man: Web of Shadows | |
| Spider-Carnage Ben Reilly | The Amazing Spider-Man 2Spider-Man Unlimited | Sam Riegel |
| Stilt-Man Wilbur Day | Spider-Man: Web of Shadows | |
| Tarantula Anton Miguel Rodriguez | Spider-Man Unlimited | |
| Taskmaster Tony Masters | Marvel's Spider-Man | Brian Bloom |
| Tinkerer Phineas Mason | Spider-Man: The Animated SeriesSpider-Man: Web of ShadowsMarvel: Ultimate Alliance 2Spider-Man: Shattered DimensionsSpider-Man: Miles Morales | William UtayPhilip ProctorJim CummingsTBA |
| Tombstone Lonnie Lincoln | Marvel's Spider-Man | Corey Jones |
| Toxin Patrick Mulligan | Spider-Man Unlimited | |
| Ultimate Spider-Slayer Alistair Smythe | The Amazing Spider-Man: Lethal FoesSpider-Man: The Animated SeriesThe Amazing Spider-ManSpider-Man Unlimited | Nolan North |
| Venom Angelo Fortunato | Spider-Man Unlimited | |
| Venom Eddie Brock | Spider-Man (2000)Ultimate Spider-ManSpider-Man 3Spider-Man: Friend or FoeSpider-Man: Web of ShadowsThe Amazing Spider-Man 2Spider-Man Unlimited | Daran NorrisArthur BurghardtTopher GraceQuinton FlynnKeith SzarabajkaBen Diskin |
| Vermin Edward Whelan | The Amazing Spider-Man | Steve Blum |
| Vulture Adrian Toomes | Spider-Man (2002) Spider-Man 2Ultimate Spider-ManSpider-Man: Web of ShadowsSpider-Man: Shattered DimensionsSpider-Man UnlimitedMarvel's Spider-Man | Dwight Schultz Brian GeorgeKristoffer TaboriSteve Blum Dwight Schultz |
| Wraith Yuri Watanabe | Spider-Man UnlimitedMarvel's Spider-Man | Tara Platt |

## Novels, theatre and radio

Spider-Man villains that were introduced in novels, theatre productions and radio programs.

### The Gentleman

For decades, the wealthy and misanthropic Gustav Fiers controlled a criminal organisation. Fiers had a lethal reputation in the criminal underworld, known for conducting elaborate plans to increase his own wealth, involved behind the scenes in various significant events in global history. Gustav Fiers eventually learned that Richard and Mary Parker, two agents under his employ, were double agents working for the United States government. When the Parkers were hired by Albert Malik, Fiers informed Malik of their disloyalty. Malik hired Gustav Fiers' brother, the Finisher, to kill the Parkers. The Finisher succeeded in doing so but, decades later, was killed in a battle with the Parkers' son, Spider-Man.

### Lesser threats

| Villain | Media | Creator |
| Disk Jockey | Spider-Man: Secret of the Sinister Six (2002 novel) | Adam Troy Castro |
| Pity | Spider-Man: The Gathering of the Sinister Six (1999 novel) Spider-Man: Revenge of the Sinister Six (2001 novel) Spider-Man: Secret of the Sinister Six (2002 novel) | Adam Troy Castro |
| Swiss Miss | Spider-Man: Turn Off the Dark (2011 musical) | Julie Taymor |