# A.P. Bio

A.P. Bio is an American television sitcom that premiered on February 1, 2018, on NBC as a mid-season replacement. It aired on NBC for two seasons until June 13, 2019, and moved to Peacock for its subsequent seasons. The series is focused on the everyday lives of the faculty and students of the fictitious Whitlock High School. Mike O'Brien created the series and is a recurring writer. O'Brien is also one of the executive producers alongside Seth Meyers, Lorne Michaels, Andrew Singer, and Michael Shoemaker. It is set in Toledo, Ohio.
The series is centered around Jack Griffin, played by Glenn Howerton. Griffin is a philosophy professor who, after being fired from his Harvard position, returns to his hometown and picks up teaching Advanced Placement Biology all while trying to find opportunities to move out. A.P. Bio also features a cast of Lyric Lewis, Mary Sohn, Jean Villepique, Paula Pell, and Patton Oswalt.
A.P. Bio was met with mixed reviews on its first season; however, following seasons garnered a much more positive reception. In December 2021, the series was canceled after four seasons.

## Plot

When disgraced Harvard philosophy professor Jack Griffin (Glenn Howerton) loses his dream job to his rival Miles Leonard (Tom Bennett), he is forced to return to his hometown of Toledo, Ohio, to work as an advanced placement biology teacher at Whitlock High School and live in his late mother's home. He makes it clear to his class that he will not be teaching them any biology. Realizing he has a room full of honor-roll students at his disposal, he decides to use them to get revenge on Miles. Eager to prove that he is still king of the castle, Principal Durbin (Patton Oswalt) struggles to keep Jack under control. In the second season, Jack uses his students to find out how the people of Toledo find happiness in their daily lives, to gather information for what he believes will be a bestselling book.

## Cast
### Main

* Glenn Howerton as Dr. Jack Griffin
** Tate Birchmore (season 3) and Olivier Paris (season 4) play younger versions of Jack
* Lyric Lewis as Stef Duncan, a history teacher who is friends with Jack, Mary, and Michelle
* Mary Sohn as Mary Wagner, an art teacher who is friends with Jack, Stef, and Michelle
* Jean Villepique as Michelle Jones, a health and home economics teacher who is friends with Jack, Stef, and Mary
** Michelle was played by Vanessa Bayer in the original unaired pilot episode
* Tom Bennett as Miles Leonard, a philosophy scholar and professor at Stanford University who is Jack's rival and nemesis (season 1)
* Patton Oswalt as Principal Ralph Durbin, the principal of Whitlock High School. While kind and working in the school's best interests, he is irresponsible and somewhat childlike. He plays the keyboard and sings, and was in a ska band in the 1990s.
* Paula Pell as Helen Demarcus, Principal Durbin's secretary (seasons 2–4, recurring season 1)

### Recurring

* Jacob McCarthy as Devin, a quiet, brooding student whom Jack calls "Prince of Darkness" (season 1)
* Tucker Albrizzi as Colin McConnell (season 1)
* Collette Wolfe as Meredith
* Aparna Brielle as Sarika Sarkar, an over-achieving teacher's pet who usually opposes Jack's schemes
* Nick Peine as Marcus Kasperak, the student council president who is in the AP Bio class. He is noted as being Jack's "least favorite student" and is constantly made fun of by him as a result.
* Allisyn Snyder as Heather Wilmore, a mousy girl who acts as one of Jack's most trusted students/underlings
* Eddie Leavy as Anthony Lewis, a sassy, effeminate boy
* Charlie McCrackin as Coach Dick Novak, a gym teacher who coaches the Whitlock Rams football team
* Jacob Houston as Victor Kozlowski, an extremely awkward and slow-talking boy
* Spence Moore II as Dan Decker, a former bully who is forcibly enrolled into Jack's class as a punishment
* Sari Arambulo as Grace
* Marisa Baram as Marissa
* David Neher as Dave Pugh, a science teacher who is constantly made fun of by the other teachers
* Brendan Jennings as Dale, the school's custodian, later promoted to "head custodian" by Durbin in the second season
* Yuyao Deng as Yuyao, a Chinese student in the AP Bio class
* Patricia Belcher as Superintendent Bullard (seasons 1–2, 4)
* Brad Morris as Keith (seasons 2–4)
* Elizabeth Alderfer as Lynette, a payroll accountant who befriends, and later dates, Jack (seasons 2–4)
* Miguel Lee as Eduardo, Victor's childhood best friend who transfers into the AP Biology class (seasons 2–4)
* Jacob Timothy Manown as Caleb, an AP Bio student who is also in the drama club. He writes in his free time and is a fan of Principal Durbin's old ska band. (seasons 2–4)
* Jaime Moyer as Joyce (seasons 2–4)
* Cheryl Lynn Bowers as Rosemary Griffin (seasons 3–4)
* Jane Morris as Rhonda (seasons 3–4)
* Ashley Tapia and Chloe Csengery as Ashley (season 4)
* Allison Bills as Trudy (season 4)
* Hayley Marie Norman as Shayla Howard (season 4)

### Guest stars

* Nikki Glaser as Chloe from Baltimore
* Niecy Nash as Kim Burke
* Taran Killam as Mr. Vining
* Mark Proksch as Philip
* Michael Gross as Brandon
* Christopher Lloyd as Melvin
* Erinn Hayes as Trish
* Tim Heidecker as Greg
* Brooks Wheelan as Seth
* Jon Lovitz as Robin Schwonk
* Johnny Pemberton as a saloon pianist in the AP Bio kids' fanfiction
* Ron Funches as Hans, a janitor with a double life
* Bruce Campbell as John Griffin, Jack's father
* Laura Kightlinger as Gabrielle
* Joe Manganiello as Malachi
* Janine Brito as Kylie
* Darrell Dennis as a Detective
* Angela Kinsey as Ralph's wife, Brenda

## Episodes

A.P. Bio by season :
| Season | Episodes | Episodes | Originally released | Originally released | Originally released |
| Season | Episodes | Episodes | First released | Last released | Network |
| 1 | 13 | 13 | February 1, 2018 (2018-2-1) | May 3, 2018 (2018-5-3) | NBC |
| 2 | 13 | 13 | March 7, 2019 (2019-3-7) | June 13, 2019 (2019-6-13) | NBC |
| 3 | 8 | 8 | September 3, 2020 (2020-9-3) | September 3, 2020 (2020-9-3) | Peacock |
| 4 | 8 | 8 | September 2, 2021 (2021-9-2) | September 2, 2021 (2021-9-2) | | Peacock |

### Season 1 (2018)

A.P. Bio season 1, episodes :
| No. overall | No. in season | Title | Directed by | Written by | Original release date | Prod. code | U.S. viewers (millions) |
| 1 | 1 | "Pilot: Catfish" | Oz Rodriguez | Mike O'Brien | February 1, 2018 (2018-2-1) | 101 | 3.12 |
| When Harvard philosophy scholar Jack Griffin finds himself teaching high school in Toledo, he tosses the syllabus and recruits his students to help mentally break his dream-job-stealing nemesis Miles Leonard. In this episode, Jack encourages his students to catfish Miles on social media. ||||||||
| 2 | 2 | "Teacher Jail" | Oz Rodriguez | Rob Klein | February 25, 2018 (2018-2-25) (broadcast) February 2, 2018 (2018-2-2) (online) | 102 | 5.89 |
| The kids fake an injury when Jack leaves the class unattended, sending him into a lengthy arbitration process where he is not allowed back in class but has to go to "teacher jail" where he's paid to not teach. The kids are first assigned Helen as the substitute teacher, who does a terrible job due to her utter lack of qualifications and awkwardness. The kids request another substitute, who arrives in class and is excited to teach them biology. While in the arbitration process, Jack has moral qualms about hurting the Principal Ralph's reputation and so decides to return to work. ||||||||
| 3 | 3 | "Burning Miles" | Oz Rodriguez | Luvh Rakhe | March 1, 2018 (2018-3-1) (broadcast) February 2, 2018 (2018-2-2) (online) | 103 | 2.70 |
| While Principal Durbin struggles with budget cuts, Jack discovers his students pity him - so he rallies, making a splash at the school bake sale and getting kicked out of the bookstore for life. ||||||||
| 4 | 4 | "Overachieving Virgins" | Julie Anne Robinson | John Blickstead & Trey Kollmer | March 1, 2018 (2018-3-1) | 104 | 2.60 |
| Jack gets into a petty dispute with Marcus, the President of Student Council, who surprisingly refuses to back down, causing the situation to escalate much too far. Meanwhile, Stef sells makeup at school as a side business. ||||||||
| 5 | 5 | "Dating Toledoans" | Ryan Case | Aseem Batra | March 8, 2018 (2018-3-8) | 105 | 2.33 |
| Jack, who has been taking buses to New York to meet dates, is convinced to let Stef, Mary, and Michelle show him how to enjoy Toledo. Meanwhile, Principal Durbin finds out that his announcements have not been as well received as he had previously believed when Helen covers for him and entertains everyone. ||||||||
| 6 | 6 | "Freakin' Enamored" | Oz Rodriguez | Shelly Gossman | March 15, 2018 (2018-3-15) | 106 | 3.07 |
| When Jack is attracted to Colin's mother at a parent–teacher conference, he feigns interest in her son only to have it backfire. Meanwhile, a group of parents complain to principal Durbin when they notice a piece of controversial student art from Mary's class, resulting in her inciting a protest. ||||||||
| 7 | 7 | "Selling Out" | Payman Benz | Donick Cary | March 22, 2018 (2018-3-22) | 107 | 2.87 |
| After Jack receives an offer from Miles's publisher to write a book of feel-good philosophy, he enlists the help of Helen in hopes of using the deal as his ticket out of Toledo. Meanwhile, principal Durbin accidentally sets off an emotional firestorm when he reveals who Mary chose as her emergency contact. ||||||||
| 8 | 8 | "We Don't Party" | Daniel Gray Longino | Nicole Sun | March 29, 2018 (2018-3-29) | 108 | 2.05 |
| Jack finds out his ex-girlfriend needs a venue for a charity fundraiser and suggests a student's house; the kids are inspired by Jack to party for the first time. ||||||||
| 9 | 9 | "Rosemary's Boyfriend" | Maggie Carey | Mike O'Brien & Charlie McCrackin | April 5, 2018 (2018-4-5) | 109 | 2.21 |
| Jack is incensed when his dead mom's former lover shows up and suggests they celebrate her birthday; Jack taps his students to help him retaliate, but they are busy caring for robot babies; Stef's kindness toward the janitor sends the wrong signals. ||||||||
| 10 | 10 | "Durbin Crashes" | Andrew DeYoung | Mike O'Brien & Rob Klein | April 12, 2018 (2018-4-12) | 110 | 2.05 |
| Jack takes in Durbin after giving him marriage advice that backfires and gets him kicked out of the house; the kids try to help Jack get revenge against Miles. ||||||||
| 11 | 11 | "Eight Pigs and a Rat" | Carrie Brownstein | Mike O'Brien & Zeke Nicholson | April 19, 2018 (2018-4-19) | 111 | 1.83 |
| The class receives a shipment of fetal pigs for dissection, but Jack cancels the dissection and fails an attempt at shooting the pigs at Miles. The superintendent visits Whitlock High School in order to evaluate Durbin for an "Innovative Principal of the Year" nomination; she is disappointed when each teacher presents a volcano as a supposed part of their curriculum. Jack and Heather demonstrate a live dissection session, using a full-grown hog that Heather stole from her father's butcher shop, and the superintendent is satisfied. ||||||||
| 12 | 12 | "Walleye" | Tristram Shapeero | Mike O'Brien & Britt Matt | April 26, 2018 (2018-4-26) | 112 | 1.69 |
| Jack successfully convinces Miles that Devin is his illegitimate son; Durbin, Mary, Stef and Michelle clash on the Sadie Hawkins dance theme. ||||||||
| 13 | 13 | "Drenching Dallas" | Lynn Shelton | Mike O'Brien & Jeff Vanderkruik & Brian Ashburn | May 3, 2018 (2018-5-3) | 113 | 2.03 |
| Jack takes interest in a revenge mission on behalf of the kids; Mary, Stef and Michelle believe they've discovered an otherworldly presence. ||||||||

### Season 2 (2019)

A.P. Bio season 2, episodes :
| No. overall | No. in season | Title | Directed by | Written by | Original release date | Prod. code | U.S. viewers (millions) |
| 14 | 1 | "Happiness" | Trent O'Donnell | Donick Cary | March 7, 2019 (2019-3-7) | 201 | 1.88 |
| Jack attempts to unlock the secret of what makes ordinary people happy, leading him to an idea for a new book that he believes will be his ticket out of Whitlock High. Plus, Mary, Stef and Michelle celebrate a special day. ||||||||
| 15 | 2 | "Nuns" | Lynn Shelton | John Blickstead & Trey Kollmer | March 14, 2019 (2019-3-14) | 202 | 1.96 |
| As the newly minted driver's education teacher, Jack sets out to get revenge on his mother's church when he discovers the last of her money was used to buy a statue of the Virgin Mary. ||||||||
| 16 | 3 | "Wednesday Morning, 8 AM" | John Solomon | Mike O'Brien | March 21, 2019 (2019-3-21) | 203 | 2.23 |
| In the hectic 30 minutes that start every day at Whitlock, Jack tries to retrieve his massage chair from Whitlock's intriguing payroll accountant, Lynette; Durbin and Helen prepare for the morning announcements; Michelle gives a eulogy. ||||||||
| 17 | 4 | "Toledo's Top 100" | Maggie Carey | Emily Cutler | March 28, 2019 (2019-3-28) | 204 | 2.33 |
| Jack is aghast to learn he didn't make the top 10 in Toledo's Top 100 Bachelors, and Durbin did; Victor and Eduardo decide it's time to reveal their feelings to their crushes. ||||||||
| 18 | 5 | "J'accuse" | Andy DeYoung | Mike O'Brien & Charlie McCrackin | April 4, 2019 (2019-4-4) | 205 | 1.91 |
| Jack tries to impress Lynette using Michelle's annual murder mystery party as a distraction. Plus, desperate students break into Whitlock High to steal the AP biology practice exams. ||||||||
| 19 | 6 | "Melvin" | Katie Locke O'Brien | Dan Klein | April 11, 2019 (2019-4-11) | 206 | 2.05 |
| Jack's war with his neighbor Melvin (Christopher Lloyd) reaches a turning point when it threatens a potential date with Lynette. Plus, the school photographer increases his payment rate, so Durbin comes up with his own plan for school picture day. ||||||||
| 20 | 7 | "Personal Everest" | John Solomon & Andy DeYoung | Shelly Gossman | April 18, 2019 (2019-4-18) | 207 | 1.81 |
| Jack is furious when his former high school bully is hired as a motivational speaker at Whitlock. Plus, Mary, Stef and Michelle set their own personal goals for female empowerment, accidentally causing a rift between Helen and Durbin. ||||||||
| 21 | 8 | "Sweet Low Road" | Richie Keen | Donick Cary & Emily Cutler | April 25, 2019 (2019-4-25) | 208 | 1.66 |
| When budget cuts threaten to gut Whitlock and put his job in jeopardy, Jack recruits Mary, Stef and Michelle to take down the superintendent; Durbin plans an appeal to the heart, while the students plan an appeal to the soul. ||||||||
| 22 | 9 | "Dr. Whoopsie" | Blake McClure | Mike O'Brien & Rob Klein | May 2, 2019 (2019-5-2) | 209 | 1.79 |
| When an embarrassing video of him falling off a stage goes viral, Jack plans a viral video of his own. Plus, Durbin, Helen and the teachers hunt down Whitlock's most notorious litterer known as The Sugar Daddy. ||||||||
| 23 | 10 | "Handcuffed" | Jennifer Arnold | Paula Pell | May 30, 2019 (2019-5-30) | 210 | 2.26 |
| When he's kicked off his Harvard phone plan, Jack is offered a chance to leapfrog onto Mary's on one condition -- he must help her break up with her scuzzy boyfriend; Anthony becomes Durbin's right-hand man. ||||||||
| 24 | 11 | "Spectacle" | Carrie Brownstein | Amy Hubbs | May 30, 2019 (2019-5-30) | 211 | 1.60 |
| When his computer breaks, Jack rallies his class to win the annual Whitlock's Got Talent competition so he can use the prize money for a new laptop. Plus, Helen and Durbin host the show, while Mary, Stef and Michelle perform a hand-bell routine. ||||||||
| 25 | 12 | "Ride the Ram" | Mike O'Brien | Mike O'Brien & John Solomon | June 13, 2019 (2019-6-13) | 212 | 1.58 |
| It's the most exciting time of the year at Whitlock: Durbin's birthday and Spirit Week; Jack does his best to steer clear of any school spirit as everyone else comes together to take down their hated rivals at Prairie High. ||||||||
| 26 | 13 | "Kinda Sorta" | Trent O'Donnell | Teleplay by : John Blickstead & Trey Kollmer Story by : Shelly Gossman & Britt Matt | June 13, 2019 (2019-6-13) | 213 | 1.38 |
| Sarika has an offer for Jack when the university fair comes to Whitlock- get her into Harvard and she'll get his book to her publisher aunt. Plus Stef prepares for a visit from a fling, while Helen applies to university. ||||||||

### Season 3 (2020)

A.P. Bio season 3, episodes :
| No. overall | No. in season | Title | Directed by | Written by | Original release date | Prod. code |
| 27 | 1 | "Tiny Problems" | Oz Rodriguez | Donick Cary | September 3, 2020 (2020-9-3) | 301 |
| Hoping to continue a childhood tradition, Jack orders a new popcorn maker but is disappointed when he received a prop for a doll house. Jack enlists his students to get revenge on the store that sold him the dollhouse prop, and decides to use a glitter bomb in one of her dollhouses. Helen goes back to school to get her high school degree and is one of Jack's students; he uses her to distract that storeowner to hide the glitter bomb. When Helen catches Jack making fun of her, he changes his mind and he and Helen break into the store to remove the glitter bomb, but Helen trips and destroys numerous dollhouses. Principal Durbin takes over Helen's secretarial roles in her absence, and is quickly overwhelmed. Jack's girlfriend repairs his popcorn maker, and he is content to continue his old tradition. |||||||
| 28 | 2 | "Disgraced" | Oz Rodriguez | Shelly Gossman | September 3, 2020 (2020-9-3) | 302 |
| Mr. Pugh plans a field trip for the Toledo chapter of the Ohio Naturalists; but Victor is unable to get permission to go. He hacks Durbin's email and attempts to extort him to let students go on the field trip, but he confesses when Durbin is about to go through an embarrassing act on school television, and Durbin cancels the trip. Jack meets with Sarika's aunt, but finds that instead of publishing his book, she wants him to ghostwrite a book for famous author, Robin Schwonk. Schwonk claims to hate Jack's work, causing Jack to hide his own chapters in Schwonk's book, with the hope that Schwonk will get in trouble for plagiarizing Jack's work. Schwonk reveals that he was simply tormenting Jack and loved the book, but then later discovered Jack's plot and bought the rights to Jack's book, keeping him out of trouble and stopping Jack's plans to publish his book. |||||||
| 29 | 3 | "Gary Meets Dave" | Richie Keen | Dan Schofield | September 3, 2020 (2020-9-3) | 303 |
| Jack accidentally loses a significant amount of money and it falls in the hands of the students, who believe they are buying drugs when they are buying flour. The other teachers fear that they accidentally killed someone in their walking group and concoct an elaborate story to cover for it, despite him not being dead. Dale, the janitor, poses as a teacher when his wife visits him at work. Principal Durbin and Helen investigate who stole the money, the students and teachers admit to their wrongdoings. |||||||
| 30 | 4 | "Get Hoppy!" | Glenn Howerton | Jess Lacher | September 3, 2020 (2020-9-3) | 304 |
| Principal Durbin takes it upon himself to help Jack advance his book with an appearance on Toledo's morning TV show but lets his five minutes of fame get the best of him; the other teachers lead a competition within the Young Entrepreneurs Club. |||||||
| 31 | 5 | "Mr. Pistachio" | Oz Rodriguez | Gilli Nissim | September 3, 2020 (2020-9-3) | 305 |
| Jack has Mary drive him to the doctor, but a prank results in him getting the same procedure twice; at school, Durbin and Helen embarrass themselves and the kids compete over class superlative titles. |||||||
| 32 | 6 | "That That That" | Richie Keen | Charlie McCrackin | September 3, 2020 (2020-9-3) | 306 |
| As the school prepares for winter break, Jack tries to record a lecture on Thoreau's transcendentalism as a way into the University of Wisconsin's philosophy department; frustrated and unable to finish the video, he falls asleep and has nightmares. |||||||
| 33 | 7 | "Aces Wild" | Oz Rodriguez | Shelly Gossman & Brendan Jennings | September 3, 2020 (2020-9-3) | 307 |
| Principal Durbin and Helen sweep lockers; Jack finds out that Anthony has been lying about his extracurricular activities; Jack and Lynette follow Anthony to find out what he's really been up to; the search for Stef's baby donor intensifies. |||||||
| 34 | 8 | "Katie Holmes Day" | Anu Valia | Debbie Jhoon & Michael J. Feldman | September 3, 2020 (2020-9-3) | 308 |
| While the rest of the town prepares for the celebration of Toledo's annual Katie Holmes Day, Jack and Marissa plot to ruin the holiday pageant. |||||||

### Season 4 (2021)

A.P. Bio season 4, episodes :
| No. overall | No. in season | Title | Directed by | Written by | Original release date | Prod. code |
| 35 | 1 | "Tornado!" | Katie Locke O'Brien | Mike O'Brien | September 2, 2021 (2021-9-2) | 401 |
| A tornado puts the school on lockdown and Helen believes it's coming specifically for her; the kids pass the time by writing fan fiction, "shipping" various combinations of faculty members; Mery, Stef and Michelle devise a plan to escape the school. |||||||
| 36 | 2 | "Sweatpants" | Katie Locke O'Brien | Rob Klein | September 2, 2021 (2021-9-2) | 402 |
| Jack has the students form a fake cult to sabotage Principal Durbin's new school uniforms; Mary, Stef and Michelle prepare to see one of their favorite artists who is in town to perform. |||||||
| 37 | 3 | "An Oath to Rusty" | Katie Locke O'Brien | Shelly Gossman | September 2, 2021 (2021-9-2) | 403 |
| Jack attempts to get closer with the guys at work by inviting them over for a game night; Helen helps Principal Durbin grow a backbone; Stef and Mary try to coax information out of Michelle about the court case she was a juror on. |||||||
| 38 | 4 | "Tons of Rue" | Katie Locke O'Brien | John Blickstead & Trey Kollmer | September 2, 2021 (2021-9-2) | 404 |
| When the A.P. Bio students reunite Jack with his deadbeat dad, Jack plots revenge by trying to expose his allegedly reformed father; a witch foretells of a grim future for Mary, Stef and Michelle that divides the women. |||||||
| 39 | 5 | "The Perfect Date from Hell" | Oz Rodriguez | David Neher & Charlie McCrackin | September 2, 2021 (2021-9-2) | 405 |
| When Jack discovers his new girlfriend's therapy homework requires dating him, he turns the tables on her; Principal Durbin goes undercover to determine which faculty member is most worthy of a very special prize. |||||||
| 40 | 6 | "Love, for Lack of a Better Term" | Heath Cullens | Jess Lacher | September 2, 2021 (2021-9-2) | 406 |
| Victor attempts to catch up to his peers and become a man by sending Ashlanda a risqué photo; Grace and Anthony try to "Parent Trap" Mary and Principal Durbin after overhearing a conversation that makes them take pity on the single adults. |||||||
| 41 | 7 | "Malachi" | Heath Cullens | Debbie Jhoon & Michael J. Feldman | September 2, 2021 (2021-9-2) | 407 |
| When Jack's girlfriend says she's going to dinner with a male friend (Joe Manganiello), a jealous Jack tags along; Principal Durbin, Mary, Stef and Michelle take Helen out to cheer her up after a breakup. |||||||
| 42 | 8 | "The Harvard Pen" | Oz Rodriguez | Teleplay by : Clayton English & Hadiyah Robinson Story by : Brendan Jennings | September 2, 2021 (2021-9-2) | 408 |
| Jack is enraged to find that the A.P. Bio students have stolen his beloved Harvard pen after he asked them not to touch it; Principal Durbin and Helen repeatedly fail the superintendent's inspections. |||||||

## Production
### Development

The series was created by Mike O'Brien for NBC, to debut during the 2017–18 television season. On January 23, 2017, NBC officially ordered the pilot. The series was greenlit on May 11, 2017. It was announced the premiere of the series on February 1, 2018 at 8:30 p.m.
On May 8, 2018, NBC renewed the series for a second season, which premiered on March 7, 2019. On May 24, 2019, NBC canceled the series after two seasons. In July 2019, NBC reversed this decision and renewed the series for a third season, which premiered on NBCUniversal's streaming service, Peacock, on September 3, 2020. On December 17, 2020, Peacock renewed the series for a fourth and final season, which premiered on September 2, 2021. On December 6, 2021, Peacock canceled the series after four seasons.

### Casting

In February 2017, it was announced that Mary Sohn and Lyric Lewis had joined the pilot's main cast. In March 2017, it was reported that Aparna Brielle, Glenn Howerton, Patton Oswalt, Nick Peine and Jacob McCarthy had joined the cast in their main roles. On June 12, 2017, it was announced that Tom Bennett had joined as a series regular. On August 1, 2017, it was announced that Jean Villepique had joined as a series regular.

## Reception
### Critical response

The first season holds a score of 66% with an average rating of 6.34/10 on the review aggregation website Rotten Tomatoes, based on 32 reviews. The site's critical consensus states, "A.P. Bio has some genuine laughs, but audiences have already seen plenty of authority figures behaving badly—and have a right to expect more from this promising premise and talented cast." Metacritic, which uses a weighted average, assigned the series a score of 59 out of 100 based on 17 critics.
Writing in The Hollywood Reporter, Daniel Fienberg commented that A.P. Bio had a good cast and "the only thing holding it back is the small quibble that it's not actually all that funny." Margaret Lyons of The New York Times called A.P. Bio "an abrasive sitcom that isn't merely unfunny, it's also deeply unpleasant." Jen Chaney of Vulture said the series had bright spots but was "conceptually played-out" overall.

### Ratings
#### Overall

Viewership and ratings per season of A.P. Bio :
| Season | Timeslot (ET) | Episodes | First aired | First aired | Last aired | Last aired | TV season | Viewership rank | Avg. viewers (millions) |
| Season | Timeslot (ET) | Episodes | Date | Viewers (millions) | Date | Viewers (millions) | TV season | Viewership rank | Avg. viewers (millions) |
| 1 | Thursday 8:30 pm | 13 | February 1, 2018 (2018-2-1) | 3.12 | May 3, 2018 (2018-5-3) | 2.03 | 2017–18 | 134 | 3.54 |
| 2 | Thursday 8:30 pm | 13 | March 7, 2019 (2019-3-7) | 1.88 | June 13, 2019 (2019-6-13) | 1.38 | 2018–19 | 149 | 2.50 |

#### Season 1

Viewership and ratings per episode of A.P. Bio :
| No. | Title | Air date | Rating/share (18–49) | Viewers (millions) |
| 1 | "Catfish" | February 1, 2018 | 0.8/3 | 3.12 |
| 2 | "Teacher Jail" | February 25, 2018 | 1.4/6 | 5.89 |
| 3 | "Overachieving Virgins" | March 1, 2018 | 0.7/3 | 2.70 |
| 4 | "Burning Miles" | March 1, 2018 | 0.7/3 | 2.60 |
| 5 | "Dating Toledoans" | March 8, 2018 | 0.7/3 | 2.33 |
| 6 | "Freakin' Enamored" | March 15, 2018 | 0.9/3 | 3.07 |
| 7 | "Selling Out" | March 22, 2018 | 0.8/3 | 2.87 |
| 8 | "We Don't Party" | March 29, 2018 | 0.6/2 | 2.05 |
| 9 | "Rosemary's Boyfriend" | April 5, 2018 | 0.6/2 | 2.21 |
| 10 | "Durbin Crashes" | April 12, 2018 | 0.6/3 | 2.05 |
| 11 | "Eight Pigs and a Rat" | April 19, 2018 | 0.6/3 | 1.83 |
| 12 | "Walleye" | April 26, 2018 | 0.5/2 | 1.69 |
| 13 | "Drenching Dallas" | May 3, 2018 | 0.6/3 | 2.03 |

#### Season 2

Viewership and ratings per episode of A.P. Bio :
| No. | Title | Air date | Rating/share (18–49) | Viewers (millions) |
| 1 | "Happiness" | March 7, 2019 | 0.5/3 | 1.88 |
| 2 | "Nun" | March 14, 2019 | 0.5/3 | 1.96 |
| 3 | "Wednesday Morning, 8 AM" | March 21, 2019 | 0.5/3 | 2.23 |
| 4 | "Toledo's Top 100" | March 28, 2019 | 0.5/3 | 2.33 |
| 5 | "J'accuse" | April 4, 2019 | 0.5/3 | 1.99 |
| 6 | "Melvin" | April 11, 2019 | 0.5/3 | 2.05 |
| 7 | "Personal Everest" | April 18, 2019 | 0.5/3 | 1.81 |
| 8 | "Sweet Low Road" | April 25, 2019 | 0.4/2 | 1.66 |
| 9 | "Dr. Whoopsie" | May 2, 2019 | 0.5/3 | 1.79 |
| 10 | "Handcuffed" | May 30, 2019 | 0.4/2 | 2.26 |
| 11 | "Spectacle" | May 30, 2019 | 0.4/2 | 1.60 |
| 12 | "Ride the Ram" | June 13, 2019 | 0.3/2 | 1.58 |
| 13 | "Kinda Sorta" | June 13, 2019 | 0.3/2 | 1.38 |

## Home media

The first season of A.P. Bio was released on DVD in the United States on August 14, 2018 and in Australia on June 6, 2019