# Substituted lysergamide

Substituted lysergamides are amides of lysergic acid and are collectively known as lysergamides or ergoamides. They include a number of compounds with potent agonist and/or antagonist activity at various serotonin and dopamine receptors, such as lysergic acid diethylamide (LSD) and lysergic acid amide (LSA; ergine), among others. Lysergamides contain an embedded tryptamine structure, and as a result can produce similar, often psychedelic, effects to those of the true tryptamines.

## Use and effects

The dosages, potencies, durations, and effects of lysergamides have been reviewed by Alexander Shulgin.

## List of substituted lysergamides

Lysergamides, tabulated by structure :
| Name | CAS number | R1 | R6 | R2 | R3 | Other |
| LSA / LAA | 478-94-4 | H | CH$_3$ | H | H | - |
| DAM-57 | 4238-84-0 | H | CH$_3$ | CH$_3$ | CH$_3$ | - |
| Ergometrine (Ergonovine) | 60-79-7 | H | CH$_3$ | CH(CH$_3$)CH$_2$OH | H | - |
| Ergotamine | 113-15-5 | H | CH$_3$ | -- | C$_{17}$H$_{18}$N$_2$O$_4$ | - |
| Methergine | 113-42-8 | H | CH$_3$ | CH(CH$_2$CH$_3$)CH$_2$OH | H | - |
| Methysergide | 361-37-5 | CH$_3$ | CH$_3$ | CH(CH$_2$CH$_3$)CH$_2$OH | H | - |
| Amesergide | 121588-75-8 | CH(CH$_3$)$_2$ | CH$_3$ | C$_6$H$_{11}$ | H | - |
| LY-215840 | 137328-52-0 | CH(CH$_3$)$_2$ | CH$_3$ | C$_5$H$_8$OH | H | - |
| Cabergoline | 81409-90-7 | H | H$_2$C=CH-CH$_2$ | CONHCH$_2$CH$_3$ | CH$_2$CH$_2$CH$_2$N(CH$_3$)$_2$ | - |
| LAE-32 | 478-99-9 | H | CH$_3$ | CH$_2$CH$_3$ | H | - |
| LAiP | | H | CH$_3$ | CH(CH$_3$)$_2$ | H | - |
| LAtB | | H | CH$_3$ | C(CH$_3$)$_3$ | H | - |
| LAcB | | H | CH$_3$ | (CH$_2$)$_4$ | H | - |
| Cepentil | | H | CH$_3$ | (CH$_2$)$_5$ | H | - |
| LSB | 137765-82-3 | H | CH$_3$ | CH(CH$_3$)CH$_2$CH$_3$ | H | - |
| LSP | | H | CH$_3$ | CH(CH$_2$CH$_3$)CH$_2$CH$_3$ | H | - |
| DAL | | H | CH$_3$ | H$_2$C=CH-CH$_2$ | H$_2$C=CH-CH$_2$ | - |
| MIPLA | 100768-08-9 | H | CH$_3$ | CH(CH$_3$)$_2$ | CH$_3$ | - |
| EIPLA | | H | CH$_3$ | CH(CH$_3$)$_2$ | CH$_2$CH$_3$ | - |
| ECPLA | | H | CH$_3$ | C$_3$H$_5$ | CH$_2$CH$_3$ | - |
| ETFELA | | H | CH$_3$ | CH$_2$CF$_3$ | CH$_2$CH$_3$ | - |
| LAMPA | 40158-98-3 | H | CH$_3$ | CH$_2$CH$_2$CH$_3$ | CH$_3$ | - |
| EPLA | | H | CH$_2$CH$_3$ | CH$_2$CH$_2$CH$_3$ | CH$_3$ | - |
| LSD / LAD | 50-37-3 | H | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| ETH-LAD | 65527-62-0 | H | CH$_2$CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| PARGY-LAD | | H | HC≡C−CH$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| AL-LAD | 65527-61-9 | H | H$_2$C=CH-CH$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| PRO-LAD | 65527-63-1 | H | CH$_2$CH$_2$CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| IP-LAD | | H | CH(CH$_3$)$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| CYP-LAD | | H | C$_3$H$_5$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| BU-LAD | 96930-87-9 | H | CH$_2$CH$_2$CH$_2$CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| FLUORETH-LAD | | H | CH$_2$CH$_2$F | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| ALD-52 | 3270-02-8 | COCH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1P-LSD | 2349358-81-0 | COCH$_2$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1B-LSD | 2349376-12-9 | COCH$_2$CH$_2$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1V-LSD | | CO(CH$_2$)$_3$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1H-LSD | | CO(CH$_2$)$_4$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1DD-LSD | | CO(CH$_2$)$_{10}$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1cP-LSD | | COC$_3$H$_5$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1D-LSD | | COC$_4$H$_5$(CH$_3$)$_2$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1T-LSD | | COC$_4$H$_3$S | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1S-LSD | | CO(CH$_2$)$_2$Si(CH$_3$)$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1P-AL-LAD | | COCH$_2$CH$_3$ | H$_2$C=CH-CH$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1cP-AL-LAD | | COC$_3$H$_5$ | H$_2$C=CH-CH$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1T-AL-LAD | | COC$_4$H$_3$S | H$_2$C=CH-CH$_2$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1P-ETH-LAD | | COCH$_2$CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| 1P-MIPLA | | COCH$_2$CH$_3$ | CH$_3$ | CH(CH$_3$)$_2$ | CH$_3$ | - |
| MLD-41 | 4238-85-1 | CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | - |
| LSM-775 | 4314-63-0 | H | CH$_3$ | CH$_2$CH$_2$-O-CH$_2$CH$_2$ | CH$_2$CH$_2$-O-CH$_2$CH$_2$ | - |
| LPD-824 | 2385-87-7 | H | CH$_3$ | (CH$_2$)$_4$ | (CH$_2$)$_4$ | - |
| LSD-Pip | 50485-23-9 | H | CH$_3$ | (CH$_2$)$_5$ | (CH$_2$)$_5$ | - |
| LSD-Azapane | | H | CH$_3$ | (CH$_2$)$_6$ | (CH$_2$)$_6$ | - |
| LSZ | 470666-31-0 | H | CH$_3$ | CH$_2$(CHCH$_3$)$_2$CH$_2$ | CH$_2$(CHCH$_3$)$_2$CH$_2$ | - |
| 2-Bromo-LSD | 478-84-2 | H | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | 2-Br |
| 1P-BOL-148 | | COCH$_2$CH$_3$ | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | 2-Br |
| 12-Methoxy-LSD | 50484-99-6 | H | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | 12-OMe |
| 13-Fluoro-LSD | | H | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | 13-F |
| 14-Hydroxy-LSD | | H | CH$_3$ | CH$_2$CH$_3$ | CH$_2$CH$_3$ | 14-OH |