# 2021 Open Città di Bari – Singles

This was the first edition of the tournament.
Oscar Otte won the title after defeating Daniel Masur 7–5, 7–5 in the final.

## Seeds

* Carlos Taberner (second round)
* Holger Rune (first round, retired)
* Oscar Otte (champion)
* Maxime Cressy (first round)
* Nikola Milojević (first round)
* Federico Gaio (first round)
* Roberto Marcora (first round)
* Daniel Masur (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Thomas Fabbiano | 4 | 4 | | | | | |
| 3 | Oscar Otte | 6 | 6 | | | | | |
| 3 | Oscar Otte | 6 | 6 | | 3 | Oscar Otte | 7 | 7 |
| | | | | | 8 | Daniel Masur | 5 | 5 |
| 8 | Daniel Masur | 7 | 3 | 7$^7$ | 8 | Daniel Masur | 5 | 5 |
| | Andrea Vavassori | 5 | 6 | 6$^5$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | C Taberner | 6 | 6 | | | | | | | | | | | | | | | |
| Q | A Bellier | 2 | 2 | | 1 | C Taberner | 6$^6$ | 3 | | | | | | | | | | |
| | R Brancaccio | 6 | 6 | | | R Brancaccio | 7$^8$ | 6 | | | | | | | | | | |
| WC | Luca Potenza | 2 | 3 | | | | | | | | R Brancaccio | 2 | 7 | 2 | | | | |
| | Y Maden | 6$^5$ | 1 | | | | | | | | T Fabbiano | 6 | 5 | 6 | | | | |
| | J Draper | 7$^7$ | 6 | | | J Draper | 4 | 3 | | | | | | | | | | |
| | T Fabbiano | 7$^{10}$ | 6 | | | T Fabbiano | 6 | 6 | | | | | | | | | | |
| 7 | R Marcora | 6$^8$ | 3 | | | | | | | | | | | | | T Fabbiano | 4 | 4 |
| 3 | O Otte | 6 | 6 | | | | | | | | | | | | 3 | O Otte | 6 | 6 |
| WC | O Ovcharenko | 3 | 4 | | 3 | O Otte | 6 | 6$^3$ | 7 | | | | | | | | | |
| Q | S Fanselow | 4 | 6 | 7 | Q | S Fanselow | 3 | 7$^7$ | 5 | | | | | | | | | |
| | D Stricker | 6 | 4 | 5 | | | | | | 3 | O Otte | 6 | 6 | | | | | |
| | N Sánchez Izquierdo | 6 | 2 | 0 | | | | | | | F Cobolli | 3 | 3 | | | | | |
| | F Cobolli | 3 | 6 | 6 | | F Cobolli | 7$^{12}$ | 2 | 6 | | | | | | | | | |
| | T Kamke | 6 | 6 | | | T Kamke | 6$^{10}$ | 6 | 1 | | | | | | | | | |
| 6 | F Gaio | 3 | 4 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | D Masur | 6 | 6 | | | | | | | | | | | | | | | | |
| Q | Fabrizio Andaloro | 4 | 4 | | 8 | D Masur | 6$^7$ | 7$^7$ | 6 | | | | | | | | | | |
| | F Forti | 6 | 4 | 6 | | F Forti | 7$^9$ | 6$^1$ | 3 | | | | | | | | | | |
| Q | F Maestrelli | 4 | 6 | 3 | | | | | | 8 | D Masur | 7$^7$ | 6$^6$ | 6 | | | | | |
| | J Lenz | 7 | 5 | 6 | | | | | | WC | L Nardi | 6$^5$ | 7$^8$ | 4 | | | | | |
| | T van Rijthoven | 5 | 7 | 4 | | J Lenz | 3 | 2 | | | | | | | | | | | |
| WC | L Nardi | 6 | 6 | | WC | L Nardi | 6 | 6 | | | | | | | | | | | |
| 4 | M Cressy | 4 | 1 | | | | | | | | | | | | 8 | D Masur | 7 | 3 | 7$^7$ |
| 5 | N Milojević | 1 | 5 | | | | | | | | | | | | | A Vavassori | 5 | 6 | 6$^5$ |
| | A Vavassori | 6 | 7 | | | A Vavassori | 4 | 7$^{12}$ | 6 | | | | | | | | | | |
| | M Bachinger | 6 | 4 | 4 | | A Pellegrino | 6 | 6$^{10}$ | 2 | | | | | | | | | | |
| | A Pellegrino | 4 | 6 | 6 | | | | | | | A Vavassori | 3 | 3 | | | | | | |
| PR | F Baldi | 6 | 6 | | | | | | | PR | F Baldi | 6 | 1$^r$ | | | | | | |
| | P Kotov | 0 | 4 | | PR | F Baldi | 6 | 3 | 6 | | | | | | | | | | |
| | A Arnaboldi | 6 | 1 | | | A Arnaboldi | 4 | 6 | 3 | | | | | | | | | | |
| 2 | H Rune | 4 | 0$^r$ | | | | | | | | | | | | | | | | |