# 2021 TK Sparta Prague Open – Singles

Adam Pavlásek was the defending champion but chose not to defend his title.
Dalibor Svrčina won the title after defeating Dmitry Popko 6–0, 7–5 in the final.

## Seeds

* Nikola Milojević (quarterfinals)
* Dmitry Popko (final)
* Lorenzo Giustino (second round)
* Facundo Mena (semifinals)
* Nicolás Jarry (first round)
* Riccardo Bonadio (quarterfinals)
* Adrián Menéndez Maceiras (second round)
* Michael Vrbenský (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Jonáš Forejtek | 5 | 4 | | | | |
| WC | Dalibor Svrčina | 7 | 6 | | | | |
| WC | Dalibor Svrčina | 7 | 6 | WC | Dalibor Svrčina | 6 | 7 |
| | | | | 2 | Dmitry Popko | 0 | 5 |
| 4 | Facundo Mena | 1 | 2 | 2 | Dmitry Popko | 0 | 5 |
| 2 | Dmitry Popko | 6 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | N Milojević | 6$^2$ | 6 | 6 | | | | | | | | | | | | | | |
| | A Arnaboldi | 7$^7$ | 0 | 1 | 1 | N Milojević | 3 | 6 | 3 | | | | | | | | | |
| Q | G Blancaneaux | 6 | 6 | | Q | G Blancaneaux | 6 | 3 | 1$^r$ | | | | | | | | | |
| | A Ritschard | 1 | 3 | | | | | | | 1 | N Milojević | 4 | 3 | | | | | |
| | FC Jianu | 6 | 6 | | | | | | | | J Forejtek | 6 | 6 | | | | | |
| | JC Aragone | 0 | 2 | | | FC Jianu | 2 | 6 | 1 | | | | | | | | | |
| | J Forejtek | 4 | 6 | 6 | | J Forejtek | 6 | 4 | 6 | | | | | | | | | |
| 5 | N Jarry | 6 | 4 | 2 | | | | | | | | | | | | J Forejtek | 5 | 4 |
| 3 | L Giustino | 7$^7$ | 6 | | | | | | | | | | | | WC | D Svrčina | 7 | 6 |
| | E Karlovskiy | 6$^4$ | 2 | | 3 | L Giustino | 6$^4$ | 6 | 3 | | | | | | | | | |
| | E Furness | 4 | 6 | 6 | | E Furness | 7$^7$ | 4 | 6 | | | | | | | | | |
| WC | Martin Krumich | 6 | 4 | 3 | | | | | | | E Furness | 5 | 7 | 4 | | | | |
| | T Skatov | 3 | 2 | | | | | | | WC | D Svrčina | 7 | 5 | 6 | | | | |
| WC | D Svrčina | 6 | 6 | | WC | D Svrčina | 6$^5$ | 6 | 6 | | | | | | | | | |
| | F Baldi | 3 | 6$^2$ | | 7 | A Menéndez Maceiras | 7$^7$ | 1 | 4 | | | | | | | | | |
| 7 | A Menéndez Maceiras | 6 | 7$^7$ | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | M Vrbenský | 4 | 2 | | | | | | | | | | | | | | |
| | E Tiurnev | 6 | 6 | | | E Tiurnev | 3 | 4 | | | | | | | | | |
| | C Ugo Carabelli | 1 | 6 | 6 | | C Ugo Carabelli | 6 | 6 | | | | | | | | | |
| Q | F Agamenone | 6 | 4 | 4 | | | | | | C Ugo Carabelli | 3 | 7$^8$ | 1 | | | | |
| Q | A Andreev | 3 | 3 | | | | | | 4 | F Mena | 6 | 6$^6$ | 6 | | | | |
| | N Serdarušić | 6 | 6 | | | N Serdarušić | 2 | 4 | | | | | | | | | |
| | L Miedler | 2 | 5 | | 4 | F Mena | 6 | 6 | | | | | | | | | |
| 4 | F Mena | 6 | 7 | | | | | | | | | | | 4 | F Mena | 1 | 2 |
| 6 | R Bonadio | 6 | 2 | 6 | | | | | | | | | | 2 | D Popko | 6 | 6 |
| | M Zverev | 3 | 6 | 3 | 6 | R Bonadio | 6 | 6 | | | | | | | | | |
| PR | G Melzer | 6 | 2 | 1 | Q | E Nava | 4 | 3 | | | | | | | | | |
| Q | E Nava | 3 | 6 | 6 | | | | | 6 | R Bonadio | 3 | 2 | | | | | |
| WC | T Kodat | 3 | 1 | | | | | | 2 | D Popko | 6 | 6 | | | | | |
| | G Oliveira | 6 | 6 | | | G Oliveira | 0 | 3 | | | | | | | | | |
| | A Vatutin | 5 | 1 | | 2 | D Popko | 6 | 6 | | | | | | | | | |
| 2 | D Popko | 7 | 6 | | | | | | | | | | | | | | |