OpenLLM-France/wikimedia huggingface dataset:
# Lovotibeglogene autotemcel

Lovotibeglogene autotemcel, sold under the brand name Lyfgenia, is a lentiviral gene therapy used for the treatment of sickle cell disease.
The most common side effects include stomatitis (mouth sores of the lips, mouth, and throat), low levels of platelets, white blood cells, and red blood cells, and febrile neutropenia (fever and low white blood cell count), consistent with chemotherapy and underlying disease.
The US Food and Drug Administration (FDA) approved lovotibeglogene autotemcel in December 2023.

## Medical uses

Lovotibeglogene autotemcel is indicated for the treatment of people aged twelve years of age and older with sickle cell disease and a history of vaso-occlusive events.
The recipient's blood stem cells are genetically modified to produce HbA (T87Q), a gene-therapy derived hemoglobin A, which is similar to the normal adult hemoglobin produced in persons not affected by sickle cell disease. Red blood cells containing HbA (T87Q) have a lower risk of sickling and occluding blood flow. These modified stem cells are then delivered to the recipient.
The gene therapy is made from the recipient's own blood stem cells, which are modified, and are given back as a one-time, single-dose infusion as part of a hematopoietic (blood) stem cell transplant. Prior to treatment, the recipient's own stem cells are collected, and then the recipient must undergo myeloablative conditioning (high-dose chemotherapy), a process that removes cells from the bone marrow so they can be replaced with the modified cells in lovotibeglogene autotemcel.

## Side effects

The US FDA label contains a black box warning about hematologic malignancy (blood cancer).

## History

The safety and effectiveness of lovotibeglogene autotemcel is based on the analysis of data from a single-arm, 24-month multicenter study in participants with sickle cell disease and history of Vaso-occlusive episodes (VOEs) between the ages of twelve and fifty years. Effectiveness was evaluated based on complete resolution of VOEs (VOE-CR) between six and eighteen months after infusion with lovotibeglogene autotemcel. Twenty-eight (88%) of 32 participants achieved VOE-CR during this time period.
The FDA granted the application for lovotibeglogene autotemcel priority review, orphan drug, fast track, and regenerative medicine advanced therapy designations. The FDA granted approval of Lyfgenia to Bluebird Bio Inc.
In March 2025, Cohen Children's Medical Center announced that through the use of this treatment the first person in New York State was cured of sickle cell anemia.

## Society and culture
### Economics

The cost effectiveness threshold of the therapy is estimated to be between US$1.35 million to $2.05 million.

### Brand names

Lovotibeglogene autotemcel is the international nonproprietary name.
Lovotibeglogene autotemcel is sold under the brand name Lyfgenia.
# 74 (number)

74 (seventy-four) is the natural number following 73 and preceding 75

## In mathematics

74 is:
* the twenty-first distinct semiprime and the eleventh of the form (2.q), where q is a higher prime.
* with an aliquot sum of 40, within an aliquot sequence of three composite numbers (74, 40, 50, 43, 1,0) to the Prime in the 43-aliquot tree.
* a palindromic number in bases 6 (202$_6$) and 36 (22$_{36}$).
* a nontotient.
* the number of collections of subsets of {1, 2, 3} that are closed under union and intersection.
* φ(74) = φ(σ(74)).
There are 74 different non-Hamiltonian polyhedra with a minimum number of vertices.
# Andre Sepp

Andre Sepp (born 25 October 1971) is an Estonian politician. He was a member of XII and XIII Riigikogu, representing the Estonian Reform Party.
Andre Sepp graduated from Tallinn 13th Secondary School and the Estonian National Defense Academy. He worked in the Harju Police Prefecture from 1992 to 1997. He was the Mayor of Raasiku Parish from 1999 until 2011 and the chairman of the Harju County Local Government Association from 2002 until 2007. As of 31 October 2017, he was again the mayor of Raasiku Parish.
# LeoCAD

LeoCAD is a free and open-source 3D CAD program for creating virtual Lego models by using parts from LDraw library. It was developed by Leonardo Zide in 1997.

## History

LeoCAD is developed and released by Leonardo Zide around 1997 under GPL v2 free and open source software license. Its written in C++ and uses Qt as GUI. At first it was a standalone CAD software with its own brick library, but soon it was updated to adopt the LDraw library and file format, an unofficial Lego parts collection that was very popular at the time. As of 2024, LDraw contains over 10.000 pieces and still gets updated with new bricks.
In 2021, Leonardo received James Jessiman Memorial Award from LDraw community for his creation of LeoCAD and contributions to the parts library.

## Features

LeoCAD allows users to build Lego models in a CAD environment with LDraw bricks library which is installed by default to make it easier for users to start building. Apart from LDraw, it is possible to import other custom brick libraries. LeoCAD also enables users to track each part which can be used to generate step-by-step instruction just like in official Lego sets.
Parts can be selected from the part selector and directly dragged into the building area where they can be moved or rotated via arrows with customizable precision. Building area provides 6 virtual cameras built-in which can be used to focus on different parts of the build. Other tools include additional cameras for alternative view angles, omni lights and spotlight.
By default, LeoCAD saves builds as LDraw-compatible LDR and MPD (Multi-Part Document) file format. It supports exporting builds as Wavefront OBJ, COLLADA DAE and Autodesk 3DS models and curating brick lists in CSV, HTML and BrickLink-compatible XML. It also has a built-in POV-Ray render option.

## Usage

LeoCAD and LDraw parts are mentioned in academic research and used in projects. In 2008, a group of academics from Technical University of Lisbon wrote a paper that reviews available LEGO CAD tools of the time including LeoCAD and made suggestions on how to improve virtual brick building experience. They created their own software with gravity and collisions, and compared it with LeoCAD in terms of efficiency. In 2019, LeoCAD was used for designing virtual 3d model of a Lego Mindstorms based robot for autonomous vehicle simulation research which got revealed in an IEEE conference of that year.
# The Accounts of Jingkang

The Accounts of Jingkang (Chinese: 靖康稗史) is a series of Chinese books about the events of the Jingkang incident, which took place in 1127 in the Song dynasty, credited to be one of the most detailed accounts about the Jurchen-led Jin dynasty in the Jin–Song Wars and its aftermath.

## Contents

There are 7 books in the series:
* Tour of Duty to Jin in 1119 – 1125 AD (宣和乙巳奉使金國行程錄)
* Tales of a man in bottle (甕中人語)
* Accounts in Kaifeng (開封府狀)
* Expedition to the South (南征錄彙)
* Tales of the Green Palace (青宮譯語)
* Moaning (呻吟語)
* Records of the Song Captives (宋俘記)
Among them, Tour of Duty could be found in other contemporary sources, which was about the records of Emperor Huizong of Song's envoy for the ascension of Emperor Taizong of Jin in 1125. The other six books, however, can only be found in The Accounts of Jingkang, and all of them are about the Jin–Song Wars and the abduction of the House of Zhao after the war.
As recorded in the first preface of The Accounts of Jingkang, Que An (確庵) first compiled the book in 1164, by the time titled A Record of Shared Ire (同憤錄), and it was kept by Gu family of Lin'an Prefecture, but the former half of it was lost. As of 1267, Nai An (耐庵) discovered the book, believing that the lost content was about events before the Jingkang incident, so he added two Song books as alternatives accordingly. The other preface of the book, might have been written by King Taejong of Joseon dated 1407, claimed that the book was once King Chungnyeol of Goryeo's collection; the epilogue further argued that the book spread in Joseon and Japan, before being known in China, by the time of the Qing dynasty in the late 19th century.

## History

In 1892, Xie Jiafu (謝家福) gave a manuscript of The Accounts of Jingkang to Ding Bing (丁丙), who believed that the said editor "Nai An" might have been Shi Nai'an (author of the early Chinese novel Water Margin), and it later became the collection of the Nanjing Library and collated by Ding Bingheng (丁秉衡) as of 1910. The most common modern edition of the book was published in 1939, yet it lacks proofreading and was later revised by the Zhonghua Book Company in 1988. As it is believed that the content of The Accounts of Jingkang were first-person narrative by people of both Song and Jin dynasty, researchers generally consider the book veritable after its discovery.
However, The Accounts of Jingkang is not listed in the Joseon Dynasty Series titles, which contains the available books from Joseon. According to several inconsistencies, including location differences before and after the Yellow River flood in 1128, some researchers from China and Japan doubt that The Accounts of Jingkang might be a false document.
# R. W. Lindholm Service Station

The R. W. Lindholm Service Station is a service station designed by Frank Lloyd Wright and located in Cloquet, Minnesota, United States. Built in 1958 and still in use, it is the only station built to a Wright design during his lifetime. It was originally part of Wright's utopian Broadacre City plan and is one of the few designs from that plan that was actually implemented. The building is listed on the National Register of Historic Places.

## History

Wright had designed station owner Ray Lindholm's house in 1952 and, knowing Lindholm worked in the oil business, presented him with a proposal to design the gas station envisioned as part of Broadacre City. Lindholm seized the opportunity to beautify gas station design, and Wright completed his design in 1956. The station ultimately cost $20,000 – roughly four times the cost of the average filling station at the time.
The station opened in 1958 under Lindholm's name; it later became a Phillips 66 station.
Its construction was only a partial success for Wright, as his vision of the gas station as a social center never took hold. However, Phillips 66 incorporated several of the gas station's design elements, particularly the triangular cantilevered canopy, in later gas stations.
The station was added to the National Register of Historic Places on September 11, 1985, for its architectural significance.
As of 2014, it operates under the Spur brand.
In 2018, the grandchildren of Ray Lindholm sold the gas station to Minneapolis real estate developer and entrepreneur Andrew Volna.

## Design

In his original plans for Broadacre City, Wright designed his service stations to be community social centers and an integral part of his utopian ideas. His design of the Lindholm Service Station reflects these plans and represents a then-unconventional approach to filling station design. A cantilevered copper canopy extends over the gas pumps; the angular end of the canopy points to the St. Louis River, a feature Wright intended to symbolically connect river transport to the automobile. While Wright had planned to install overhead gas pumps suspended from the canopy to add space, local safety regulations compelled him to install conventional ground-based pumps. Beneath the canopy is an observation lounge with glass walls, originally intended to be the social center envisioned in the Broadacre City plans. The station's service bays are built from stepped cement blocks; the stepping, as well as the recessed mortar between the rows of blocks, provides a horizontal element to the building. Skylights allow sunlight into the service bays.
Despite the importance of gas stations to the Broadacre City concept, the building was the only Wright-designed service station built in his lifetime. Another service station designed by Wright is part of the Pierce-Arrow Museum in Buffalo, New York; while he designed the station in 1927, it was not built until 2013.
# Nyírbátor

Nyírbátor (Hungarian:) is a town in Szabolcs-Szatmár-Bereg county, in the Northern Great Plain region of eastern Hungary. With its historic atmosphere, this city is known for its 15th- and 16th-century ecclesiastic and secular architectural heritage and for the Báthory family, former landowners.

## Geography

It covers an area of 66.73 km$^2$ (26 sq mi) and has a population of 12,259 (2015). The town forms the largest and most important population centre of the southern Nyírség region of Hungary.

## History

The first written record of the settlement dates from 1279. Its name stems from the Old Turkish word 'batir' or Mongolian 'bator' (originally meaning a 'good hero', and corresponding to 'bátor' in modern Hungarian). At that time, the ancestors of the Báthorys, the Gutkeled clan, already owned the land. The town became the administrative centre of their estates and also the family burial site. The family owned the town until the death of Gabriel Báthory, Prince of Transylvania in 1613.
The town was of great significance in Hungarian history during the 16th century. In 1549, the legates of King Ferdinand I and of Isabella agreed to return Transylvania to the Kingdom of Hungary. During the decades that followed there was a lasting dispute as to whom the town belonged since the local aristocrats were more inclined to recognise the sovereignty of the ruling prince of Transylvania.
By the 18th century the town had become impoverished. In the course of the 1872 reorganisation of public administration it lost its city rights that were returned only in 1973.

## Sights

Numerous heritage buildings have remained from the town's heyday. The most well-known is what is now the Reformed Church. Built between 1488 and 1511, it is one of the most notable International Gothic structures in Hungary. The late Renaissance-style belfry next to it is the largest wooden bell tower in the country.
Franciscan friars built their friary church around 1480 in a late Gothic style. Its altars and its pulpit are among the most beautifully carved Baroque works in the country. Standing near the church is the building which now houses the István Báthori Museum. Originally a Baroque Minorite friary, it was built on the site of an earlier monastery.

## Sport

The association football club, Nyírbátori FC, is based in Nyírbátor.

## Photo gallery

* Báthory Castle
* István Báthori Museum
* Our Lady church
* Reformed church
* Reformed belfry
* Town hall

## Notable people

* Elizabeth Bathory (1560–1614), Hungarian countess and, allegedly, the most prolific female serial killer in history
* Meshulam Gross (1863–1947), Hungarian-American entrepreneur

## Twin towns – sister cities

Nyírbátor is twinned with:
* Carei, Romania
* Khust, Ukraine
* Rawa Mazowiecka, Poland
* Șimleu Silvaniei, Romania
* Vynohradiv, Ukraine
# Peter Herzberg

Peter Herzberg is an American politician from Michigan. In April 2024, Herzberg won a special election to fill the vacant District 25 in the Michigan House of Representatives. He was reelected to a full term in 2024.
He was a member of Westland City Council.
# Juan Vargas (disambiguation)

Juan Vargas (born 1961) is an American politician.
Juan Vargas may also refer to:
* Juan Camilo Vargas (born 1994), Colombian squash player
* Juan Manuel Vargas (born 1983), football (soccer) player from Peru
* Tetelo Vargas (Juan Esteban Vargas, 1906–1971), baseball player from the Dominican Republic
* Juan Vargas (judoka), Salvadoran judoka
# Lexical Variant Generation (software)

Lexical Variant Generation (lvg) is a suite of CLI tools that are used to perform lexical transformations to text. The goal is to generate lexical variants in Natural language processing of patient clinical documents.
# Mahony's toadlet

Mahony's toadlet (Uperoleia mahonyi) is a species of small frog that is endemic to Australia. The specific epithet honours Professor Michael Mahony of the University of Newcastle for contributions to the study of Australian frogs.

## Description

The species grows to about 35 mm in length (SVL). The upper body is brown to dark brown, which may be patched with grey, pale pink or orange-brown, and often has a triangular brown patch on the head. The tops of the arms are sometimes yellow. The belly is marbled black and bluish-white. The fingers and toes are unwebbed. The backs of the thighs and groin are bright orange.

## Behaviour

Breeding takes place in spring and summer. Eggs are attached singly to submerged vegetation in ponds and swamps.

## Distribution and habitat

The species’ known range is limited to the Central Coast region of New South Wales on the east coast of Australia. The frogs are found in coastal swamps, occasionally in dams, in heath or wallum habitats on white sand soils, and acidic paperbark swamps.

## Conservation status

As of March 2021, the species is classified as endangered under the Environment Protection and Biodiversity Conservation Act 1999.
# Paulo Angeles

Miguel Paulo Detera Angeles (born October 27, 1997) is a Filipino actor, singer and dancer. Angeles is a talent of ABS-CBN under Star Magic. Angeles was first seen on TV via Mirabella, a Philippine melodramatic fantasy television series in 2014. In 2015, Angeles became a member of It's Showtime's Kilig Ambassadors: Hashtags.

## Personal life

Angeles is continuing his studies at Trinity University of Asia, taking up BS Marketing.

## Filmography
### Film

| Year | Title | Role | Studio |
| 2016 | Just the 3 of Us | EJ Manalo | Star Cinema |
| 2017 | Love You to the Stars and Back | Kenneth | Star Cinema |
| 2017 | You with Me | Timmy | Gitana Film Production |
| 2018 | So Connected | Enzo | Regal Entertainment |
| 2019 | Sakaling Maging Tayo | Emerson "Emer" Igcasan | Black Sheep Productions |
| 2019 | G! | Bryan | Cineko Productions |
| 2019 | Santigwar | Jay | Reality Entertainment, Horseshoe Studios |

### Television

| Year | Title | Role | Network |
| 2014 | Mirabella | Nico | ABS-CBN |
| 2014 | Maalaala Mo Kaya: Notebook | Michael | ABS-CBN |
| 2014 | Sana Bukas pa ang Kahapon | Ryan | ABS-CBN |
| 2014 | Maalaala Mo Kaya: Salamin | Janno | ABS-CBN |
| 2014–2015 | Dream Dad | Manuel Castro | ABS-CBN |
| 2015 | It's Showtime | Himself / Dancer/ Performer | ABS-CBN |
| 2015 | Maalaala Mo Kaya: Bottled Water | Joey | ABS-CBN |
| 2016 | Minute To Win It: Last Man Standing | Himself / Player/ Contestant | ABS-CBN |
| 2016 | Family Feud | Himself / Player/ Contestant | ABS-CBN |
| 2016 | Pinoy Big Brother: Lucky Season 7 | Himself / House Guest | ABS-CBN |
| 2016 | Ipaglaban Mo: Kapatiran | Justin | ABS-CBN |
| 2017 | Langit Lupa | Ivan | ABS-CBN |
| 2017 | Ipaglaban Mo: Houseboys | Nonong | ABS-CBN |
| 2017–2018 | La Luna Sangre | Mark | ABS-CBN |
| 2018 | Ipaglaban Mo: Hazing | Jomar | ABS-CBN |
| 2018 | Precious Hearts Romances Presents: Araw Gabi | Frederico "Red" De Alegre Jr. / Frederico "Red" Mamaril | ABS-CBN |
| 2019 | Maalaala Mo Kaya: Journal | John Hennesy Olivas | ABS-CBN |
| 2019 | Parasite Island | Miggy Salvacion | ABS-CBN |
| 2019 | Taiwan That You Love | Eric | iWant |
| 2020 | Bawal Lumabas: The Series | Onyx | iWant |
| 2020–2021 | Ang sa Iyo ay Akin | Angelo "Gelo" Marasigan | Kapamilya Channel |
| 2021 | Magandang Buhay | Himself / Guest | Kapamilya Channel |
| 2021 | FPJ's Ang Probinsyano | Jim De Castro | Kapamilya Channel |
| 2022 | Suntok sa Buwan | Barok | TV5 |
| 2022 | Sunday's Best Special: Star Magic All Star Game 2022 | Himself / Player | Kapamilya Channel |
| 2023 | Replacing Chef Chico | Juancho | Netflix |
| 2024–present | ASAP Natin 'To | Himself / Co-host / Performer | Kapamilya Channel / A2Z / TV5 |
| 2024 | Ang Himala ni Niño | Noli | TV5 |

## Awards and nominations

| Year | Film Awards/ Critics | Awards | Nominated Work | Result |
| 2016 | 8th PMPC Star Awards for Music | Dance Album of the Year | Hashtags | Won |
# Gouda railway station

Gouda is a railway station in Gouda, Netherlands. The station opened on 21 May 1855 when the Nederlandsche Rhijnspoorweg-Maatschappij (Dutch Rijn Railway Company) opened the Utrecht–Rotterdam railway. The Gouda–Den Haag railway to The Hague was opened in 1870, and the connection to Alphen a/d Rijn in 1934.
Trains running between Den Haag Centraal / Rotterdam Centraal and Utrecht Centraal call at the station, as well as the RijnGouweLijn connection to Alphen a/d Rijn.
In November 1944, during World War II, the strategically located railway station was bombed by the Royal Air Force. The main building of the railway station was severely damaged; traces of the bombing are visible to this day on platforms 3 and 5. In 1948 a new building was constructed out of the remaining first floor of the old building. This was replaced by the current building in 1984. In 2022 the building and related nearby infrastructure were renovated.

## Train services

The following train services call at Gouda:
* 1x per hour intercity service Rotterdam – Utrecht – Amersfoort – Zwolle – Groningen
* 1x per hour intercity service Rotterdam – Utrecht – Amersfoort – Zwolle – Leeuwarden
* 2x rush hour intercity service Rotterdam – Utrecht
* 1x per hour intercity service The Hague – Utrecht – Amersfoort – Hengelo – Enschede
* 1x per hour intercity service The Hague – Utrecht – Amersfoort – Amersfoort Schothorst
* 2x per hour rush hour intercity service The Hague – Utrecht
* 2x per hour local service (sprinter) Rotterdam – Gouda – Gouda Goverwelle – Woerden – Amsterdam – Uitgeest
* 2x per hour local service (sprinter) Rotterdam – Gouda – Gouda Goverwelle (Peak hours only)
* 2x per hour local service (sprinter) The Hague – Gouda – Gouda Goverwelle – Utrecht
* 2x per hour local service (sprinter) The Hague – Gouda – Gouda Goverwelle (Weekdays only)
* 4x per hour local service (sprinter) Gouda – Alphen aan den Rijn

## Bus services

* 1
* 2
* 3
* 4
* 106
* 107
* 175
* 178
* 190
* 196
* 278 (rush hour 178)
* 386
* 497
* 726