# Mie potential

The Mie potential is an interaction potential describing the interactions between particles on the atomic level. It is mostly used for describing intermolecular interactions, but at times also for modeling intramolecular interaction, i.e. bonds.
The Mie potential is named after the German physicist Gustav Mie; yet the history of intermolecular potentials is more complicated. The Mie potential is the generalized case of the Lennard-Jones (LJ) potential, which is perhaps the most widely used pair potential.
The Mie potential $V(r)$ is a function of $r$, the distance between two particles, and is written as
$V(r)=C\,\varepsilon \left[\left({\frac {\sigma }{r}}\right)^{n}-\left({\frac {\sigma }{r}}\right)^{m}\right],~~~~~~(1)$
with
$C={\frac {n}{n-m}}\left({\frac {n}{m}}\right)^{\frac {m}{n-m}}$ .
The Lennard-Jones potential corresponds to the special case where n=12{\textstyle n=12} and m=6{\textstyle m=6} in Eq. (1). In Eq. (1), $\varepsilon$ is the dispersion energy, and $\sigma$ indicates the distance at which $V=0$, which is sometimes called the "collision radius." The parameter σ{\textstyle \sigma } is generally indicative of the size of the particles involved in the collision. The parameters n{\textstyle n} and m{\textstyle m} characterize the shape of the potential: n{\textstyle n} describes the character of the repulsion and m{\textstyle m} describes the character of the attraction.
The attractive exponent m=6{\textstyle m=6} is physically justified by the London dispersion force, whereas no justification for a certain value for the repulsive exponent is known. The repulsive steepness parameter n{\textstyle n} has a significant influence on the modeling of thermodynamic derivative properties, e.g. the compressibility and the speed of sound. Therefore, the Mie potential is a more flexible intermolecular potential than the simpler Lennard-Jones potential.
The Mie potential is used today in many force fields in molecular modeling. Typically, the attractive exponent is chosen to be m=6{\textstyle m=6}, whereas the repulsive exponent is used as an adjustable parameter during the model fitting.

## Thermophysical properties of the Mie substance

As for the Lennard-Jonesium, where a theoretical substance exists that is defined by particles interacting by the Lennard-Jones potential, a substance class of Mie substances exists that are defined as single site spherical particles interacting by a given Mie potential. Since an infinite number of Mie potentials exist (using different n, m parameters), equally many Mie substances exist, as opposed to Lennard-Jonesium, which is uniquely defined. For practical applications in molecular modelling, the Mie substances are mostly relevant for modelling small molecules, e.g. noble gases, and for coarse grain modelling, where larger molecules, or even a collection of molecules, are simplified in their structure and described by a single Mie particle. However, more complex molecules, such as long-chained alkanes, have successfully been modelled as homogeneous chains of Mie particles. As such, the Mie potential is useful for modelling far more complex systems than those whose behaviour is accurately captured by "free" Mie particles.
Thermophysical properties of both the Mie fluid, and chain molecules built from Mie particles have been the subject of numerous papers in recent years. Investigated properties include virial coefficients and interfacial, vapor-liquid equilibrium, and transport properties. Based on such studies the relation between the shape of the interaction potential (described by n and m) and the thermophysical properties has been elucidated.
Also, many theoretical (analytical) models have been developed for describing thermophysical properties of Mie substances and chain molecules formed from Mie particles, such as several thermodynamic equations of state and models for transport properties.
It has been observed that many combinations of different ($n,m$) can yield similar phase behaviour, and that this degeneracy is captured by the parameter
$\alpha =C\left[{\frac {1}{m-3}}-{\frac {1}{n-3}}\right]$,
where fluids with different exponents, but the same $\alpha$-parameter will exhibit the same phase behavior.

## Mie potential used in molecular modeling

Due to its flexibility, the Mie potential is a popular choice for modelling real fluids in force fields. It is used as an interaction potential many molecular models today. Several (reliable) united atom transferable force fields are based on the Mie potential, such as that developed by Potoff and co-workers. The Mie potential has also been used for coarse-grain modeling. Electronic tools are available for building Mie force field models for both united atom force fields and transferable force fields. The Mie potential has also been used for modeling small spherical molecules (i.e. directly the Mie substance - see above). The Table below gives some examples. There, the molecular models have only the parameters of the Mie potential itself.
| Specie | $\sigma$ [Å] | $\varepsilon$ [$k_{B}^{-1}$] | $n$ [ – ] | $m$ [ – ] |
| ${\ce {Ar}}$ | 3.404 | 117.84 | 12.085 | 6.0 |
| ${\ce {CH_4}}$ | 3.7412 | 153.36 | 12.65 | 6.0 |
| ${\ce {H_2}}$ | 3.2574 | 17.931 | 8.0 | 6.0 |
| ${\ce {He}}$ | 3.3530 | 4.44 | 14.84 | 6.0 |
| ${\ce {Kr}}$ | 3.645 | 176.10 | 14.0 | 6.0 |
| ${\ce {N_2}}$ | 3.609 | 105.79 | 14.08 | 6.0 |
| ${\ce {O_2}}$ | 3.46 | 118.0 | 12.0 | 6.0 |