# List of Spider-Man enemies

Spider-Man is a superhero created by Marvel Comics who debuted in the anthology comic book series issue Amazing Fantasy #15 (August 1962) during the Silver Age of Comics. After his debut, he received his own comic book entitled The Amazing Spider-Man. This comic introduced many of what would become his major supervillain adversaries. Spider-Man then became popular enough for more Spider-Man comic spinoffs (The Spectacular Spider-Man, Marvel Team-Up, Web of Spider-Man, Peter Parker: Spider-Man etc.) which introduced more recurring enemies of the web-slinger, across their various incarnations.
As with Spider-Man, most of his villains' powers originate from scientific accidents or the misuse of scientific technology. They can be classified into multiple categories, such as animal-themed villains (Doctor Octopus, Vulture, Black Cat, Lizard, Rhino, Scorpion, Kraven the Hunter, Jackal, Beetle, Kangaroo, Tarantula, and Puma), villains with powers over the elements (Sandman, Electro, Molten Man, and Hydro-Man), horror-themed villains (the Green Goblin, the Hobgoblin, Morbius, Morlun, and the Symbiotes), crime lords (the Kingpin, Tombstone, Hammerhead, Silvermane, and Mister Negative), inventors (the Shocker, the Tinkerer, Spencer Smythe, and Alistair Smythe), and masters of trickery and illusion (the Chameleon and Mysterio). There are, however, numerous villains that don't fit into any specific category, such as Mephisto, the latter of whom originated as a Silver Surfer villain. The villains oftentimes form teams such as the Sinister Six to oppose the web-slinger.
Spider-Man is notable for having numerous villains that redeemed themselves and became antiheroes, such as Black Cat, the Prowler, Morbius, Kraven, Sandman and Silver Sable. Also, unlike most superheroes, Spider-Man doesn't have one particular archenemy, but rather three: the Norman Osborn version of the Green Goblin, the Otto Octavius version of Doctor Octopus, and the Eddie Brock version of Venom, the latter two of whom have been similarly redeemed and depicted as antiheroes; since the late 2000s, the demon Mephisto has additionally been depicted as an overarching archenemy/prominent adversary of all incarnations of Spider-Man.
The rogues gallery of Spider-Man has garnered positive critical acclaim and has been considered one of the greatest rogues galleries of all time.

## Debuting in Spider-Man titles

The majority of supervillains depicted in Spider-Man comics first appeared in The Amazing Spider-Man, while some first appeared in spinoff comics such as The Spectacular Spider-Man and Marvel Team-Up and other titles.

### The Amazing Spider-Man debuts

Most of the supervillains of Spider-Man would be introduced in The Amazing Spider-Man comic book starting with the Chameleon. The early villains would be introduced in the 1960s during the Silver Age of Comic Books, and created by Stan Lee and Steve Ditko. John Romita Sr. replaced Ditko starting with the Rhino. Gerry Conway later replaced Stan Lee and helped create new adversaries for the web-slinger and also helped pave the way for the Bronze Age of Comic Books with the death of Spider-Man's long-time romantic interest, Gwen Stacy. Many collaborators would soon take over The Amazing Spider-Man title. One of the more popular examples included Todd McFarlane's Venom in the Modern Age of Comic Books.
Note: Alter ego characters who are the most high profile in the supervillain alias but have shared that alias with others are in bold. Alter egos listed having N/A use their real name as supervillain name. All the villains are listed in the chronological order of their debut in comics. Characters of the central rogues gallery are in bold.

### Central rogues gallery

| Name | Notable alter ego | First appearance issue # | Creator | Descriptions |
| Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov | #1 (March 1963) | Stan Lee Steve Ditko | A master of disguise who can make himself look like anybody |
| Vulture | Adrian Toomes | #2 (May 1963) | Stan Lee Steve Ditko | An elderly inventor who created mechanical wings that allow him to fly and grant him superhuman strength |
| Doctor Octopus | Dr. Otto Gunther Octavius | #3 (July 1963) | Stan Lee Steve Ditko | Originally a brilliant scientist, his greatest invention, a set of metallic limbs, became fused to his body by an accident which caused his insanity. He has telepathic control of these arms, which are strong enough to physically hurt Spider-Man. While Doctor Octopus is regarded as one of Spider-Man's archenemies, he has also been portrayed as an antihero, and even starred in his own comic book storyline that saw him becoming a superhero called the Superior Spider-Man after the original Spider-Man's death. |
| Sandman | William Baker / Flint Marko | #4 (September 1963) | Stan Lee Steve Ditko | Once a small-time crook, he became a supervillain after his body merged with sand which he can manipulate in many ways, such as shapeshifting, increasing his density and strength to lift up to 85 tons, and creating dust storms from his body. |
| Lizard | Dr. Curtis "Curt" Connors Peter Benjamin Parker (Earth 65) | #6 (November 1963) | Stan Lee Steve Ditko | A scientist researching genetics, he injected himself with an experimental serum made from reptile DNA which transformed him into a humanoid lizard. As the Lizard, he has regeneration abilities, along with superhuman strength, speed, and agility. He has sometimes been shown as being able to telepathically command all reptiles within a one-mile radius. |
| Electro | Maxwell Dillon | #9 (February 1964) | Stan Lee Steve Ditko | Originally a lineman for an electric company, he turned to a life of crime after being struck by lightning while working on a power line and becoming a living electric capacitor. His powers range from shooting electricity bolts to flight and superhuman strength and speed, which makes him one of Spider-Man's most dangerous enemies. |
| Mysterio | Quentin Beck Daniel Berkhart Francis Klum | #13 (June 1964) | Stan Lee Steve Ditko | A master of illusion who uses special effects, hypnosis, and an extensive knowledge of chemistry and robotics to trick his enemies |
| Green Goblin | Norman Osborn (Green Goblin I) Harry Osborn (Green Goblin II) | #14 (July 1964) | Stan Lee Steve Ditko | The first Green Goblin, Norman Osborn, is the CEO of Oscorp and has powers derived from a "Goblin formula" that increases agility, endurance, strength, and reflexes to superhuman levels. The formula has also advances the intelligence while causing insanity as a side effect. He uses an arsenal of weapons created by Oscorp, such as pumpkin bombs and a personal glider. The Norman version of the Green Goblin is usually regarded as Spider-Man's archenemy. The second Goblin, Harry Osborn, is Norman's son and Peter Parker's best friend. He has the same powers as his father. |
| Kraven the Hunter | Sergei Kravinoff Alyosha Kravinoff (son) Ana Kravinoff (daughter) | #15 (August 1964) | Stan Lee Steve Ditko | Depicted as the world's greatest big-game hunter, Kraven is skilled in hand-to-hand combat, though he also uses a "magic jungle potion" to increase his speed, strength, and tracking skills. He aims to kill Spider-Man, whom he regards as his equal, to prove himself as the world's greatest hunter, and is also the half-brother of the Chameleon. |
| Scorpion | Mac Gargan | #20 (January 1965) | Stan Lee Steve Ditko | A former private investigator who underwent a test that made him more powerful than Spider-Man, at the cost of his sanity. He gained the superhuman strength of a scorpion, and was provided with a scorpion-themed suit and weaponry (such as a tail which evolved from a simple club tail to a scythe-like spike capable of shooting lasers, acid among other projectiles). Gargan later became the third host of the Venom symbiote. |
| Rhino | Aleksei Mikhailovich Sytsevich | #41 (October 1966) | Stan Lee John Romita Sr. | A Russian thug who was given a rhinoceros-modeled armor, which give him superhuman strength and resistance, after undergoing a chemical and radiation treatment. After escaping from his handlers, he used his newfound powers to become a supervillain. |
| Shocker | Herman Schultz | #46 (March 1967) | Stan Lee John Romita Sr. | A former small-time criminal who built himself a battle suit that contains vibro-shock gauntlets. |
| Kingpin | Wilson Grant Fisk | #50 (July 1967) ("Spider-Man No More!") | Stan Lee John Romita Sr. | Depicted as crime lord of New York City. Manipulate henchman to do his bidding. His body consists of mostly muscle (despite looking like he is obese) that has much strength and agility. Enough to grapple and hammer Spider-Man. |
| Morbius | Michael Morbius | #101 (October 1971) | Roy Thomas Gil Kane | A formerly renowned biochemist who was mutated into a vampire. He has all the powers and weaknesses of a vampire. Later comic book storylines depict him as a tragic antihero. |
| Jackal | Miles Warren | #129 (February 1974) | Gerry Conway Ross Andru | A brilliant professor with the knowledge of cloning, which he uses to torment Spider-Man emotionally. The Jackal possesses superhuman strength, speed, and agility. There are two versions of the Jackal that operate independently of each other; the original being Miles Warren, while his clone goes by the alias of the Carrion. |
| Black Cat | Felicia Hardy | #194 (July 1979) | Marv Wolfman Keith Pollard | A master cat burglar, who inherited her name and skills from her father. She often carries a grappling hook for swinging on rooftops, and sometimes has bad luck powers. She has often been depicted as both a love interest and ally of Spider-Man. |
| Hydro-Man | Morris Bench | #212 (January 1981) | Denny O'Neil John Romita Jr. | A former crewman who gained aquakinetic abilities following an accident during Spider-Man's fight with Namor. |
| Hobgoblin | Roderick Kingsley Jason Macendale Ned Leeds Phil Urich Demogoblin | #238 (March 1983) | Roger Stern John Romita Sr. | Roderick Kingsley discovered one of Norman Osborn's lairs and perfected the Green Goblin formula, which granted him superhuman strength and intelligence without Osborn's insanity. Using a vast arsenal of weapons similar to the Green Goblin's, including a goblin glider, pumpkin bombs and razor-sharp bats, Kingsley became the criminal mastermind known as the Hobgoblin. |
| Venom | Eddie Brock (Venom I) Mac Gargan (Venom II) | #300 (May 1988) | David Michelinie Todd McFarlane | Eddie Brock is a former reporter who blamed Spider-Man for ruining this career and his life. He became Venom after binding with the symbiote that once merged with Spider-Man. As Venom, he has the same powers as Spider-Man, and aims to ruin his life in any way he can. He is also undetectable to Spider-Man's spider sense. While Venom grew to be regarded as one of Spider-Man's archenemies, later comic book storylines depict him as an antihero, and he even reluctantly teamed up with Spider-Man when the lives of innocent people were at risk. Other character have also been the host of the Venom symbiote, including Mac Gargan, who became the second Venom. |
| Carnage | Cletus Kasady | #361 (April 1992) | David Michelinie Erik Larsen Mark Bagley | An offspring of the Venom symbiote merged with a serial killer. Carnage possess powers such as shapeshifting and creating weapons from his body. He can also plant ideas in people's heads. |
| Mister Negative | Martin Li | #546 (January 2008) (full appearance) | Dan Slott Phil Jimenez | A crime boss and leader of the Inner Demons gang, who can swap between his normal appearance and his alter ego. His powers include a healing touch, mind control, and the ability to charge regular weapons with his energy. |

### Foes of lesser renown that originated in The Amazing Spider-Man

| Name | Notable alter ego | First appearance issue # | Creator | Descriptions |
| Tinkerer | Phineas T. Mason | #2 (May 1963) | Stan Lee Steve Ditko | A gifted engineer who specializes in creating gadgets from just about anything |
| Living Brain | N/A | #8 (January 1964) | Stan Lee Steve Ditko | A living robot that is designed to solve any problem |
| Big Man | Frederick Foswell | #10 (March 1964) | Stan Lee Steve Ditko | A notorious crime lord in New York City |
| The Smythe Family / Spider-Slayers | Spencer Smythe (Father) Alistair Smythe (Son) Spider-Slayers: (Multiple Names) | #25 (June 1965) | Stan Lee Steve Ditko | The Smythe Family are robotic experts who create various deadly weapons known as "Spider-Slayers" for the purpose of hunting down Spider-Man. Spencer Smythe is the initial antagonist who creates the first Spider-Slayer on behalf of J Jonah Jameson. Alistair Smythe is the paternal son of Spencer Smythe who was crippled after a lab accident while helping his father with his work. Alistair fully inherits the Spider-Slayer legacy following his father's death, eventually enhancing himself with his own technology to increase his strength and return his ability to walk. Following this upgrade Alistair takes on the alias of "The Spider-Slayer" |
| Crime Master | Various | #26 (July 1965) | Stan Lee Steve Ditko | A professional criminal who was the alias of different people |
| Molten Man | Mark Raxton | #28 (September 1965) | Stan Lee Steve Ditko | A scientist who was covered in a liquid metallic alloy that not only gives him super-strength, but also enabled him to generate heat and radiation. |
| Looter | Norton G. Fester | #36 (May 1966) | Stan Lee Steve Ditko | A poor scientist who gains superpowers from meteor gas |
| Robot Master / Gaunt | Mendel Stromm | #37 (June 1966) | Stan Lee Steve Ditko | A former college teacher and partner of Norman Osborn that became a cyborg after being betrayed by Osborn |
| Finisher | Karl Fiers | Annual #5 (November 1968) | Stan Lee Larry Lieber | |
| Man Mountain Marko | Michael Marko | #73 (June 1969) | Stan Lee John Romita Sr. | A Maggia lieutenant to Silvermane with super-strength |
| Silvermane | Silvio Manfredi | #73 (June 1969) | Stan Lee John Buscema | An aging crime boss that is later turned into a cyborg with superhuman strength |
| Prowler | Hobie Brown Aaron Davis (Ultimate) Miles Morales (Earth 42) | #78 (November 1969) | Stan Lee John Buscema | An African-American teenage prodigy created the Prowler Technology; donning a green and purple battle suit with a cape and clawed gauntlets in order to operate as a petty thief. The "Ultimate" version was depicted as the uncle of Miles Morales. |
| Kangaroo | Frank Oliver Brian Hibbs | #81 (February 1970) | Stan Lee John Buscema Jim Mooney John Romita Sr. | A name given to two kangaroo-themed villains |
| Schemer | Richard Fisk | #83 (April 1970) | Stan Lee John Romita Sr. | The son of the Kingpin |
| Gog | N/A | #103 (December 1971) | Roy Thomas Gil Kane | An alien was found by Kraven the Hunter and adopted as a pet. He quickly grew gigantic in size, and possesses superhuman strength and bracelets that allow interdimensional teleportation. |
| Gibbon | Martin Blank | #110 (July 1972) | Stan Lee John Romita Sr. | A lesser criminal with gibbon-like abilities |
| Hammerhead | Joseph (Full Name Unrevealed) | #113 (October 1972) | Gerry Conway John Romita Sr. | A mobster who had most of his skull replaced with an unbendable steel alloy |
| Man-Wolf | John Jameson | #124 (September 1973). | Gerry Conway | The son of J. Jonah Jameson, John was transformed into a werewolf after being exposed to the alien Godstone. He has been depicted as both a villain and hero. |
| Tarantula | Various | #134 (July 1974) | Gerry Conway Ross Andru | A name given to different tarantula-themed villains |
| Mindworm | William Turner | #138 (November 1974) | Gerry Conway Ross Andru | A superhuman with telepathic powers |
| Grizzly | Maxwell Markham | #139 (December 1974) | Gerry Conway Ross Andru | An ex-professional wrestler who wears a grizzly bear-themed outfit |
| Human Fly | Richard Deacon | Annual #10 (1976) | Len Wein Bill Mantlo Gil Kane | A criminal who was imprinted with the genetic code of a housefly |
| Will o' the Wisp | Jackson Arvad | #167 (April 1977) | Len Wein Ross Andru | A former Roxxon employee who can manipulate his molecules |
| Big Wheel | Jackson Wheele | #182 (July 1978) | Marv Wolfman Ross Andru Mike Esposito | A criminal who rides the Big Wheel vehicle |
| Calypso | Calypso Ezili | #209 (October 1980) | Dennis O'Neil Alan Weiss | An accomplice of Kraven the Hunter who uses voodoo potions and magic |
| Rose | Richard Fisk | #253 (June 1984) | Tom DeFalco | The alias of a gentleman-like crime lord with the alias used by different people most notably Kingpin's son Richard Fisk |
| Puma | Thomas Fireheart | #256 (September 1984) | Tom Defalco | A Native American who was bred to be a perfect warrior prophesied to stop a future threat that might destroy the world, gaining the ability to transform into a mountain lion werecat at will. |
| Slyde | Jalome Beacher | #272 (January 1986) | Tom DeFalco Sal Buscema | A chemist whose suit allow him to move at nearly 30 miles per hour (48 km/h). He is almost impossible to grasp and he is incredibly maneuverable |
| Styx and Stone | Jacob Eishorn and Gerald Stone | #309 (November 1988) | David Michelinie Todd McFarlane | A mad scientist and homeless man duo who fought Spider-Man as well as The Hulk, Venom and Cardiac. Styx has a disintegrating touch. Stone had two-large weapons on his shoulders and was later mutated into a golem-like creature. |
| Black Tarantula | Carlos LaMuerto | #419 (January 1997) | Tom DeFalco Steve Skroce | A tarantula-themed martial artist |
| Morlun | N/A | vol. 2 #30 (June 2001) | J. Michael Straczynski John Romita Jr. | A member of the Inheritors who can drain the life force of Spider-Totems. |
| Shathra | N/A | vol. 2 #46 (November 2002) | J. Michael Straczynski John Romita Jr. Scott Hanna | An insectoid creature from the Astral Plane |
| Gray Goblin | Gabriel Stacy Lily Hollister (Menace) | #509 (August 2004) #550 (April 2008) (Menace) | J. Michael Straczynski Mike Deodato | A gray-resembling Green Goblin whose alias was used by different people |
| Overdrive | James Beverley | Swing Shift (May 2007) | Dan Slott Phil Jimenez | A supervillain who can convert any vehicle into a high-powered one |
| Freak | Unknown | #546 (January 2008) | Dan Slott Steve McNiven | A drug addict turned into a superpowered being able to adapt to injuries by metamorphing into new forms. Also referred to as Armadillo Man. |
| Screwball | Unknown | #559 (May 2008) | Dan Slott Marcos Martín | The world's first "live-streaming super-villain" |
| Massacre | Marcus Lyman | #655 (April 2011) | Dan Slott Marcos Martín | A brain-damaged criminal who lacks emotions |
| Panda-Mania | Unknown | Vol. 3 #1 | Dan Slott Humberto Ramos | A panda-themed supervillain |
| Regent | Augustus Roman | Vol. 4 #1 | Dan Slott Christos Gage Paco Diaz | The CEO of Empire Unlimited whose suit enables him to copy the powers of anyone imprisoned in his stasis tubes. A version of the character from Earth-18119 first appeared in Amazing Spider-Man: Renew Your Vows as part of the "Secret Wars" storyline. |
| Kindred | Gabriel Stacy Sarah Stacy | Vol. 5 #5 | Nick Spencer Ryan Ottley | A human-turned-demon who has been revealed as Gabriel & Sarah Stacy. |

### The Spectacular Spider-Man debuts

Note: In chronological order
| Name | Alter ego | First appearance | Description |
| Lightmaster | Dr. Edward Lansky | #3 (February 1977) | A physics professor and vice-chancellor of Empire State University who became a criminal mastermind as a way to prevent budget cuts for higher education. He created a unique special power armor suit which utilized "gravity-pump circuitry" to allow him to manipulate photons for a variety of effects. |
| Carrion | Various | #25 (December 1978) | Originally a clone of Miles Warren (the Jackal), he can levitate, kill by touch, control his density and telepathy. The first Carrion was killed by an amoeba-like clone of Peter Parker, and since then other incarnations of him has appeared. |
| Iguana | None | #32 (July 1979) | An accident occurs while Dr. Connors experiments on an ordinary iguana, endowing the iguana with part of Connors' lifeforce and memories, as well as the personality and powers of Connors' alter ego, the Lizard. The Iguana becomes a human-sized semi-humanoid reptile with superhuman strength, hypnotic powers, and the ability to mentally control other reptiles. The Iguana encounters and battles Spider-Man, and is turned back into a normal iguana. |
| Answer | Aaron Nicholson | #91 (June 1984) | |
| Spot | Jonathan Ohnn | #98 (January 1985) | A scientist with the ability to create portals that lead to an alternate dimension and instantly cross short distances |
| Foreigner | Kris Keating | #115 (June 1986) | A master mercenary and assassin. |
| Sin-Eater | Stanley Carter | #107 (October 1986) | Multiple abilities ranging from artificially heightened physicality, to supernatural energy manipulation and self-healing. Was instrumental in the creation of Venom, and is also a reoccurring villain of Ghost Rider. |
| Lobo Brothers | Carlos and Eduardo Lobo | #149 (October 1988) | Two brothers who become werewolves and Drug cartel members who expanded into Texas. |

### Marvel Team-Up debuts

Note: In chronological order
| Name | Alter ego | First appearance | Creator | Description |
| Stegron | Vincent Stegron | Marvel Team-Up (1st series) #19 (March 1974) | Len Wein Gil Kane | A scientist who became a humanoid Stegosaurus using the same method that turned Curt Connors into Lizard |
| Witch-Slayer | Cotton Mather | Marvel Team-Up #41 (January 1976) | Bill Mantlo, Sal Buscema | A witch-hunter of Salem, Massachusetts in the 17th century who had been given access to mystical power by the Dark Rider |
| White Rabbit | Dr. Lorina Dodson | Marvel Team-Up #131 (July 1983) | J. M. DeMatteis Kerry Gammill Mike Esposito | A rabbit-themed supervillain, who pilots a giant rabbit mech and has a large arsenal of weapons at her disposal |
| Black Abbot | Unknown | Marvel Team-Up #147 (November 1984) | Cary Burkett Greg LaRocque | A former monk of Dakoth-Kuru, a sect that had managed to use their teachings to unlock the full potential of their minds, giving them incredible mental powers. The Black Abbot had more powers, including the ability to control the twelve others and took control of the entire brotherhood. |
| Incandescent Man | Unknown | Marvel Team-Up #149 (January 1985) | Louise Simonson Bret Blevins | Following an experiment bt Project Pegasus, he gained the ability to draw electrical energy into one's body. |

### Debuting in other Spider-Man titles

Note: In chronological order
| Name | Alter ego | First appearance | Creator | Description |
| Tombstone | Alonzo "Lonnie" Thompson Lincoln | Web of Spider-Man #36 (March 1988) | Gerry Conway Alex Saviuk | An albino mob enforcer |
| Shriek | Frances Louise Barrison | Spider-Man Unlimited #1 (May 1993) | Ron Lim Mark Bagley Mike W. Barr Tom DeFalco Jerry Bingham Terry Kavanagh | A sound-manipulating supervillain |

### Debuting outside Spider-Man titles

| Name | Alter ego | First appearance | Description |
| Beetle | Abner Jenkins Janice Lincoln | Strange Tales #123 (August 1964) | A master mechanic who wears a beetle-themed armor that went on to become the founder of The Sinister Syndicate. After Abner rebranded himself as MACH-1 to joined the initial incarnation of The Thunderbolts, Janice Lincoln, the paternal daughter of Tombstone, took over the mantle and went onto lead her own version of The Sinister Syndicate. |
| Boomerang | Fred Myers | Tales to Astonish #81 (July 1966) | A former baseball player who uses boomerangs as weapons |
| Mephisto | Stan Lee John Buscema | The Silver Surfer #3 (December 1968; originally) | A demon who manipulates Spider-Man and other superheroes into making deals with him. He is responsible for Norman Osborn's and his son Harry's initial transformations into the Green Goblin, and manipulating Norman into trading away Harry's soul and facilitating the latter's torment and transformation into the demonic Kindred. Mephisto is also responsible for manipulating Spider-Man into erasing his marriage to Mary Jane Watson from the timeline in exchange for resurrecting May Parker, and erasing his future daughter and adversary from existence. |
| Ringer | Anthony Davis | Defenders #51 (June 1977) | A supervillain who wields ring-based weapons |
| Swarm | Fritz von Meyer | Champions #14 (July 1977) | A former Nazi and beekeeper whose skeleton is surrounded by a swarm of bees |
| Jack O'Lantern | Jason Macendale | Machine Man #19 (February 1981) | A jack-o'-lantern-themed villain whose alias was used by different people. |
| Speed Demon | James Sanders | Avengers #70 (November 1960) (as the Whizzer) The Amazing Spider-Man #222 (November 1981) | A chemist with super-speed and former member of the Squadron Sinister |
| Vermin | Edward Whelan | Captain America #272 (August 1982) | A geneticist who was turned into a humanoid rat by Arnim Zola |
| Doppelganger | Spider-Doppelganger | The Infinity War #1 (July 1992) | A nearly-mindless duplicate of Spider-Man |
| Supercharger | Ronald Hiliard | Amazing Fantasy #17 (January 1996) | A supervillain who is able to absorb and store electricity |
| Proto-Goblin | Nels van Adder | Spider-Man #-1 (July 1997) | In a retcon, Norman Osborn tests the incomplete version of the formula on Oscorp employee Nels van Adder, driving van Adder insane and causing him to transform into a demonic being known as the "Proto-Goblin". Killing several people and blaming Norman for his condition, van Adder harasses and later attempts to kill him before being knocked out an Oscorp window by Chief of Security Arthur Stacy and his brother Detective George Stacy. In order to escape conviction for what he had done to van Adder, Norman convinces the police that van Adder had been experimenting on himself and that he had been trying to help him. Van Adder was last seen fleeing into the wilderness and his current fate is unknown. As well as endowing van Adder with super strength and agility, the prototypical Goblin Formula gave him claws, talons, fangs, glowing green eyes, and near-impenetrable red skin that is capable of withstanding several close range bullet shots. |
| Hippo | Mrs. Fluffy Lumpkins | Dark Reign: The Sinister Spider-Man #1 (August 2009) | A hippopotamus who was uplifted by the High Evolutionary and gained an anthropomorphic form. |

## Other villains
### Coldheart

Coldheart / Kateri Deseronto debuted in Spider-Man #49, created by Tom Lyle and Howard Mackie. She is an expert martial artist and swordsman who wields Cryonic Swords that can freeze anyone in their place.

### Lycanite

Lycanite debuted in the 1965 novel, Spiderman George Era created by Pratap Mullick's father. She is described as a horrific giant powerful flying monster from outer space that shoots burning acid. She's the only Spiderman foe that was never part of Marvel Comics

### Delilah

Delilah first appeared in The Amazing Spider-Man #414 by Tom DeFalco and Mark Bagley. A highly skilled and ruthless assassin who came under the employ of the Rose during one of the many crime-boss gang wars and became his confidante as well as his chief enforcer. She is first shown wiping out an entire room of mobsters so the Rose could maintain control of part of the New York Organize Crime. Delilah came into conflict with Spider-Man for the first time when she attempted to assassinate the ex-husband of one of Rose's employers. When the Black Tarantula first involved himself in the gang war, Delilah attempted to kill his super-strong henchman El Uno but she was overwhelmed by his power. The rematch, though, was a firm win for Delilah, with El Uno's head being mailed back to the Black Tarantula.
She also had a role during the Rose's efforts to gain extra muscle and to remove Spider-Man from interfering in their operations, in the rebirth of two of Spider-Man's old foes. She was the one who threw the switch of the electric chair which gave Electro his powers back, hoping he would eliminate Spider-Man. Electro failed, and so they devised a new plan. This time, they stole the corpse of Doctor Octopus so the Hand could succeed in restoring him to life. Delilah later found herself ambushed by the Black Tarantula himself, who easily subdued her and broke her neck, inflicting fatal injuries, but before she could die, however, the Black Tarantula instantly healed her with a message of warning for the Rose.
Attempting to find help to bring down the Black Tarantula, Delilah enlisted the aid of the new costumed adventurer Ricochet (actually Spider-Man in disguise). Together they tackled two of the Black Tarantula's operatives, Roughhouse and Bloodscream. Bloodscream grabbed hold of Delilah and caused her to bleed until she passed out. She was taken by the authorities to the hospital.
Years later she appears in Loners as an assassin smuggling MGH. When Johnny Gallo (the second Ricochet) broke into a laboratory, she thought he was the one she had teamed up with, and attacked him. Despite her skills, Johnny managed to knock her out with a cunningly thrown disc.

### Spidercide

Spidercide was a major antagonist in the "Maximum Clonage" story arc. He first appeared in The Spectacular Spider-Man #222 by Tom DeFalco and Sal Buscema. He is depicted as an evil foil of Spider-Man, Ben Reilly, and Kaine. Introduced as a red herring to suggest the possibility of a third individual that was the original Peter Parker, he is one of the Spider-Man clones created by Jackal, to be Jackal's enforcer and protector. However, Spidercide is actually a clone to Ben Reilly, who is a direct genetic duplicate of Spider-Man.
The Jackal later modified Spidercide's powers, granting him the unique ability to control his physical make-up on a molecular level; he can alter his mass, density, shape and state at will similar to the symbiotes. Despite being created to escort and protect the Jackal, Spidercide betrayed him and aligned with the Scrier. He was believed to have died after being thrown off the roof of the Daily Bugle. only to survive and return to menace Reilly shortly afterwards.

### El Muerto

El Muerto / Juan-Carlos Sanchez debuted in Friendly Neighborhood Spider-Man #5, created by Peter David and Roger Cruz.
Trained by his father Marcus Estrada de la García, Juan-Carlos gained the mystical mask and lineage of El Muertos, granting the user superhuman strength. Hesitant to do so, he battles his fellow Luchador foe El Dorado, who kills his father. Ten years go by and now Juan-Carlos is now El Muerto, who Dorado wishes to take his mask for his own. But Spider-Man aides in defeating El Dorado.
During Civil War, the United States Superhuman Registration Act (SHRA) newly-appointed S.H.I.E.L.D. Director Tony Stark classified El Muerto with further monitoring before able to join the Act.

## Antiheroes and reformed, semi-reformed, or occasionally reformed supervillains

The following is a list of Spider-Man adversaries who, at one point or another, have been reformed or semi-reformed, either temporarily or currently, or who are no longer primarily antagonists of Spider-Man. Many of these characters are now anti-heroes and have often acted as allies of the web-slinger, while others occasionally return to villain status depending on the story arc.
| Name | Alter ego | First appearance |
| Doctor Octopus | Dr. Otto Gunther Octavius | The Amazing Spider-Man #3 (July 1963) |
| Sandman | Flint Marko | The Amazing Spider-Man #4 (September 1963) |
| Lizard | Dr. Curtis "Curt" Connors | The Amazing Spider-Man #6 (November 1963) |
| Kraven the Hunter | Sergei Kravinoff | The Amazing Spider-Man #15 (August 1964) |
| Boomerang | Frederick "Fred" Myers | Tales to Astonish #81 (July 1966) |
| Beetle | Abner Jenkins | Strange Tales #123 (August 1964) |
| Molten Man | Mark Raxton | The Amazing Spider-Man #28 (September 1965) |
| Prowler | Hobart "Hobie" Brown | The Amazing Spider-Man #78 (November 1969) |
| Gibbon | Martin Blank | The Amazing Spider-Man #110 (July 1972) |
| Punisher | Frank Castle | The Amazing Spider-Man #129 (February 1974) |
| Rocket Racer | Robert Farrell | The Amazing Spider-Man #172 (September 1977) |
| Black Cat | Felicia Hardy | The Amazing Spider-Man #194 (July 1979) |
| Puma | Thomas Fireheart | The Amazing Spider-Man #256 (September 1984) |
| Silver Sable | Silver Sablinova | The Amazing Spider-Man #265 (June 1985) |
| Venom | Eddie Brock | Web of Spider-Man #18 (September 1986) |
| Solo | James Bourne | Web of Spider-Man #19 (October 1986) |
| Cardiac | Elias Wirtham | The Amazing Spider-Man #344 (December 1990) |
| Kaine | Kaine Parker | Web of Spider-Man #119 (December 1994) |
| Screwball | Unknown | The Amazing Spider-Man #559 (July 2008) |

## Non-supervillain enemies

| Name | First appearance | Description |
| Burglar | Amazing Fantasy #15 (August 1962) | The man who killed Peter's uncle, which would inspire him to use his powers responsibly and become Spider-Man. |
| Flash Thompson | Amazing Fantasy #15 (August 1962) | Early on, Flash Thompson was usually depicted as an enemy of Peter Parker and an ardent admirer of Spider-Man. He is Peter's classmate who enjoys bullying him, while ironically being one of Spider-Man's biggest fans. Later on, Flash would become good friends with Peter. In The Amazing Spider-Man #654, Flash came into contact with the Venom symbiote and became the superhero Agent Venom. |
| J. Jonah Jameson | The Amazing Spider-Man #1 (March 1963) | The editor in chief of the Daily Bugle and Peter Parker's boss. He has a strong hatred of Spider-Man and tries his best to turn the city against him by publishing fake news about him, or changing them to make it look like Spider-Man is in cahoots with the villains he is fighting. He was also responsible for the funding of the creation of Scorpion, the Spider-Slayers, and the Human Fly. |

## Group villains

| Group name | Original members | First Appearance | Description |
| Enforcers | Montana Ox Fancy Dan | The Amazing Spider-Man #10 (March 1964) | A team of mercenaries usually in the employment of crime bosses. They are generally depicted as having no super powers, but are highly skilled assassins. |
| Sinister Six | Doctor Octopus Vulture Electro Sandman Mysterio Kraven the Hunter | The Amazing Spider-Man Annual #1 (January 1964) | Brought together by Doctor Octopus, they consist of some of Spider-Man's worst enemies, who joined forces in an attempt to eliminate the web-slinger once and for all. The team had different members in its various iterations over the years, but Doctor Octopus generally remained their leader across all versions. |
| Sinister Syndicate | Beetle Hydro-Man Rhino Boomerang Speed Demon | The Amazing Spider-Man #280 (September 1986) | A team of Spider-Man villains who were inspired by the Sinister Six to band together. Unlike them, however, they are not interested in killing Spider-Man, and work for the highest bidder. |
| Spider-Man Revenge Squad | Spot Grizzly Kangaroo Gibbon | The Spectacular Spider-Man #246 (May 1997) | A team of lesser-known and weaker Spider-Man villains, also known as the Legion of Losers, who decided to join forces to stand a better chance against the web-slinger. |
| Inheritors | Solus Unnamed Matriarch Daemos Verna Karn Morlun Brix Bora | The Superior Spider-Man #33 (November 2014) | A clan of totem hunters from Earth-001 who feed from animal, human and deity totems. Their main goal is to hunt down the various versions of Spider-Man across the Marvel Multiverse and feed on their life energy. |

### Kravinoff family

Kravinoff family :
| | | | | | | | | Nikolai Kravinov | Nikolai Kravinov | Nikolai Kravinov | Nikolai Kravinov | Nikolai Kravinov | Nikolai Kravinov | | | | | | | Anna Makarova Kravinova | Anna Makarova Kravinova | Anna Makarova Kravinova | Anna Makarova Kravinova | Anna Makarova Kravinova | Anna Makarova Kravinova | | | Aleksandra Nikolaevna | Aleksandra Nikolaevna | Aleksandra Nikolaevna | Aleksandra Nikolaevna | Aleksandra Nikolaevna | Aleksandra Nikolaevna | Mikhail Aleksei Nikolaevich | Mikhail Aleksei Nikolaevich | Mikhail Aleksei Nikolaevich | Mikhail Aleksei Nikolaevich | Mikhail Aleksei Nikolaevich | Mikhail Aleksei Nikolaevich |
| Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | Dmitri Anatoly Nikolayevich Smerdyakov The Chameleon | | | Calypso Ezili The Witch of Kraven | Calypso Ezili The Witch of Kraven | Calypso Ezili The Witch of Kraven | Calypso Ezili The Witch of Kraven | Calypso Ezili The Witch of Kraven | Calypso Ezili The Witch of Kraven | | | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | Sergei Nikolaevich Kravinoff (né Kravinov) Kraven the Hunter The Unhuntable Sergei | | | | | | | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Aleksandra "Sasha" Kravinova (née Nikolaevna) | Unnamed Sisters | Unnamed Sisters | Unnamed Sisters | Unnamed Sisters | Unnamed Sisters | Unnamed Sisters |
| | | | | Xraven The Hunter X | Xraven The Hunter X | Xraven The Hunter X | Xraven The Hunter X | Xraven The Hunter X | Xraven The Hunter X | | | Nedrocci "Ned" Tannengarden | Nedrocci "Ned" Tannengarden | Nedrocci "Ned" Tannengarden | Nedrocci "Ned" Tannengarden | Nedrocci "Ned" Tannengarden | Nedrocci "Ned" Tannengarden | | | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | Anastasia "Ana" Tatiana Kravinova Kraven the Hunter | | | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter | Vladimir "Vlad" Kravinoff The Grim Hunter Son of the Hunter |
| | | | | | | | | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | Alexei Sergeevich "Alyosha" Kravinoff Kraven the Hunter | | | The Sons of Kraven | The Sons of Kraven | The Sons of Kraven | The Sons of Kraven | The Sons of Kraven | The Sons of Kraven | | | Sergei Kravinoff II The Last Son of Kraven | Sergei Kravinoff II The Last Son of Kraven | Sergei Kravinoff II The Last Son of Kraven | Sergei Kravinoff II The Last Son of Kraven | Sergei Kravinoff II The Last Son of Kraven | Sergei Kravinoff II The Last Son of Kraven |
Notes:
↑ Clone of Kraven created by Mr. Sinister, featuring the DNA of the X-Men Cyclops, Marvel Girl, the Iceman, the Angel, and the Beast, as well as a sample of the Carnage symbiote.
1 2 "Hunted" established 87 such clones of Kraven the Hunter to exist, until all are killed by one of their number, dubbed "The Last Son of Kraven" and heir to his father's identity. :

## Archenemies

Unlike most superheroes, who have a particular villain or villainous group among their adversaries with whom they have come into conflict the most (e.g., the Joker to Batman, and Lex Luthor to Superman in DC Comics; or Doctor Doom to the Fantastic Four, and the Brotherhood of Mutants to the X-Men in Marvel Comics etc.), Spider-Man is often regarded as having three archenemies, and it can be debated as to which one is the worst:
* ^ Doctor Octopus has been described as Spider-Man's greatest enemy, and the man Peter Parker might have become if he hadn't been raised with a sense of responsibility. He is infamous for defeating him the first time in battle and for almost marrying Peter's Aunt May. He is also the core leader of the Sinister Six, and at one point adopted the "Master Planner" alias. ("If This Be My Destiny...!") Later depictions revealed him in Peter Parker's body where he was the titular character for a while, ultimately becoming an antihero; on several occasions, he and Spider-Man have even put their differences aside to become allies.
* ^ The Norman Osborn version of the Green Goblin is most commonly regarded as Spider-Man's archenemy. Unlike Doctor Octopus, who only aims to kill Spider-Man, the Goblin also targeted his loved ones and showed no remorse in killing them as long as it caused pain to Spider-Man, therefore making him not only Spider-Man's worst enemy, but also Peter Parker's. His most infamous feat is killing Spider-Man's girlfriend in what became one of the most famous Spider-Man stories of all time and helped end the Silver Age of Comic Books and begin the Bronze Age of Comic Books. While the Goblin was killed in the same story, he returned in the 1990s to plague Spider-Man once again, committing more heinous acts (such as being involved of the murder of Aunt May). He also came into conflict with other heroes, such as the Avengers. Norman is sometimes depicted as an enemy of Spider-Man even when not being the Green Goblin.
* ^ The Eddie Brock incarnation of Venom is often regarded as Spider-Man's deadliest foe, and has been described as an evil mirror version of Spider-Man in many ways. He is also among Spider-Man's most popular villains. Venom's main goal is usually to ruin Peter Parker's life and mess with his head in any way he can. Despite this, Venom is not a traditional criminal, as he is only interested in hurting Spider-Man and does not engage in criminal acts, lacking the typical supervillain desires for wealth and power. The character also has a sense of honor and justice, and later starred in his own comic book stories, where he is depicted as an antihero and has a desire to protect innocent people from harm. On several occasions, he and Spider-Man have even put their differences aside to become allies.

## Reception

Reaction to Spider-Man's rogues gallery has been overwhelmingly positive with many journalists citing it as one of the greatest comic book rogues galleries of all time, with Batman's rogues gallery being its most rivaled contender. However, editors such as The Hollywood Reporter's Graeme McMillan felt that only Flash's rogues gallery can compete with Spider-Man's rogues. Kyle Schmidlin of What Culture! described the superhero's rogues gallery as "one of the most colorful in comics" explaining that Batman could only be debated as having a great number of enemies as good as Spider-Man. IGN staff editors, Joshua Yehl and Jesse Schedeen, described the Spider-Man villains as "one of the most iconic and well-balanced in comics". They opined that the scope of their schemes, how cool their powers are, and how dramatically they have affected Spider-Man's life is what makes the Spider-Man villains so great. Newsarama ranked Spider-Man's rogues gallery as number one out of ten as the greatest rogues gallery of all time.

### Themes

George Marston of Newsarama said that the reason he felt that Spider-Man's rogues gallery was the best was the thematic elements that the villains manifested. He explained that just like the superhero they have the same concept of science gone wrong. They are "like him, great men with great minds, great power, and great determination." But instead they fail to use their powers responsibly, symbolizing the thin line between being a hero and being a villain. Alex Wyse of Comic Book Resources felt that a good villain is supposed to challenge the ideals of the hero. For Spider-Man that idea was the famous quote "With great power comes great responsibility", where the superhero is pitted against an antithesis of the hero's motto like the concept of using superpowers for their personal gain.

## Me and the Boys

A viral Internet meme called "Me and the Boys", centering on images of Spider-Man foes from the 1960s Spider-Man animated series that showcases the four supervillains – the Green Goblin, Electro, Vulture and a photoshopped addition of Rhino – along with other Spider-Man foes in some variations, emerged in 2019. The meme image parodied and represented a group of friends bonding, hanging out, or engaging in various shenanigans. It originated from Reddit and, later, Twitter. It was placed as the 35th-best meme of 2019 by Thrillist.