# Second ladies and gentlemen of the United States

The second lady of the United States or second gentleman (SLOTUS or SGOTUS) is the informal title held by the spouse of the vice president of the United States, concurrent with the vice president's term of office. Coined in contrast to "first lady" – albeit used less commonly – the title "second lady" was apparently first used by Jennie Tuttle Hobart (wife of Garret Hobart, vice president 1897–1899) to refer to herself. The first second gentleman of the United States was Doug Emhoff, the husband of Kamala Harris, the vice president from 2021 to 2025 and first woman in the position.
Twelve second ladies have gone on to become first ladies during their husbands' terms as president. The first to do this was Abigail Adams, who was married to John Adams, who was the first vice president from 1789 to 1797 and then the second president from 1797 to 1801. The most recent to do this is Jill Biden, who is married to Joe Biden, the 47th vice president from 2009 to 2017 and then the 46th president from 2021 to 2025.
Since the 1970s, the vice presidential official residence is Number One Observatory Circle in Washington, D.C.

## History

The second spouse's visibility in the public sphere has been a somewhat recent development. Although the role of the first lady as White House hostess dates from the beginning of the republic (and was typically filled by another member of the president's family if the president was unmarried or a widower), with a few exceptions, it was generally not until the late 20th century and early 21st century that vice-presidential wives took on public roles that attracted significant media attention.
In one notable exception, Floride Calhoun, wife of Vice President John C. Calhoun, was a central figure in the Petticoat Affair, a social-political scandal which involved the social ostracism of Secretary of War John H. Eaton and his wife Margaret O'Neill Eaton, further damaging already-strained relations between Vice President Calhoun and President Andrew Jackson.
In 1978, Muriel Humphrey, wife of Vice President Hubert Humphrey, became the only former second lady to hold public office; after her husband, who had returned to the U.S. Senate after his term as vice president, died in office, she was appointed by Minnesota governor Rudy Perpich to continue her husband's term.
There have been 17 periods of vacancy in the role, the longest of which continued for 16 years between the service of vice presidential spouses Abigail Adams and Ann Gerry when there were three widower vice presidents and a one-year vacancy in the vice presidency. The most recent second lady vacancy was for 132 days in 1974, between the service of Betty Ford and Happy Rockefeller, when the vice presidency was also vacant.

### Role in practice

The role of the second lady or gentleman is unpaid and not formally defined. The wife of the vice president of the United States was traditionally expected to serve as a hostess and appear at society functions. Jennie Tuttle Hobart, wife of Vice President Garret Hobart (1897–1899) is often cited as the first woman to style herself as "Second Lady". Hobart took over the hostess duties on behalf of First Lady Ida Saxton McKinley, who had chronic health issues including epilepsy. Starting in 1917, the wife of the vice president took on the unofficial role of convener of the Red Cross Senate Wives, presiding over their lunches; the organization later became known as the Senate Spouses Club. The question of the second lady's status became a topic of debate in 1929 when Dolly Curtis Gann, the sister of Vice President Charles Curtis (1929–1933), assumed the role of hostess on his behalf, since he was widowed. Gann had waged a public "battle of precedence" against Alice Roosevelt Longworth, the wife of former speaker of the House Nicholas Longworth.
Over time, the spouse of the vice president started to become more visible as the Office of the Vice President itself gained power and influence, and assumed additional responsibilities. In 2010, Marie Claire magazine described the role of second ladies as being "relegated to roast-chicken charity dinners and sit-and-smile political functions. They cherry-pick a cause or two...and pretty much stay out of the way." Presidential historian Gil Troy noted that during the Kennedy administration, one of Second Lady Lady Bird Johnson's roles was to replace First Lady Jacqueline Kennedy when she withdrew from public appearances, often at the last minute; Johnson replaced Kennedy on more than 50 occasions.
Pat Nixon, wife of Vice President Richard Nixon, was the first second spouse to add a great deal of substance to the role of the vice president's wife. When Nixon assumed the position in 1953, the role's only official function was to preside over the once-annual Senate Ladies Luncheon. Instead, Nixon launched her own initiatives, sensing great opportunities that her role provided. She established a schedule separate from that of her husband, which often consisted of solo activities. As second lady, Nixon traveled more than 125,000 miles around the world to six continents, including a two-month, 42,000-mile journey through Asia in 1953. As she undertook missions of goodwill across the world, she insisted on visiting schools, orphanages, hospitals and village markets rather than attend tea or coffee functions. In this sense, Nixon essentially created the modern role of the second lady; historian Kate Andersen Brower wrote, "she helped to define this nebulous role for an entire generation of women who would succeed her." Historian Cormac O'Brien says that Pat Nixon "may have well been the most extraordinary second lady in American history" because of her role in accompanying Vice President Richard Nixon on a tour of the world as a goodwill ambassador. She also traveled independently of the vice president and attended events, including campaign tours, on her own. According to O'Brien, Second Lady Nixon proved popular "as a paragon of graciousness, composure, and elegance", and made a conscious effort to travel to locations where local women were banned, to spread a subtle message for equal rights.
During the Reagan administration, Second Lady Barbara Bush hosted more than one thousand events and traveled over 1.5 million miles at home and abroad over eight years, and championed literacy, a cause she continued to support when she later became First Lady.
Tipper Gore, former wife of Vice President Al Gore, was active in several campaigns to remove material she found objectionable from popular American entertainment, including films, television shows and music, starting when her husband was a senator. She challenged performers over their use of profane lyrics and often debated with her critics, such as Dead Kennedys singer Jello Biafra. Lynne Cheney, wife of Vice President Dick Cheney, championed education reform, citing specific failures of the American public education system during her tenure as second lady. She is a particularly outspoken supporter of American history education, having written five bestselling books on this topic for children and their families. Jill Biden, wife of President Joe Biden, worked as an English professor at Northern Virginia Community College, and is thought to be the first second lady to hold a paying job while her husband was vice president. She has been involved in various causes, including breast cancer awareness and literacy.
Douglas Emhoff, husband of Vice President Kamala Harris, became the first second gentleman of the United States when his wife became the first female vice president in 2021. He is also the first Jewish person, and the first husband to assume this ceremonial role. Emhoff is a law professor at Georgetown University Law Center. His priorities in office were advocating for food security across the United States, fight antisemitism on the international stage, address climate change, as well as push for equal access to justice. He traveled to several countries representing the United States, including France, Germany, Poland, Japan, South Korea, Philippines, Thailand, Ghana, Tanzania, and Zambia among others, having met with heads of state and attended inaugurations and state dinners.
In 2025 Usha Vance became the first Asian American second lady when her husband JD Vance became vice president.

## Current living second ladies and gentlemen

Living second ladies and gentlemen as of March 2025 (from oldest to youngest):
* Lynne Cheney (2001–2009) Born (1941-08-14)August 14, 1941 (age 83 years, 213 days)
* Tipper Gore (1993–2001) Born (1948-08-19)August 19, 1948 (age 76 years, 208 days)
* Marilyn Quayle (1989–1993) Born (1949-07-29)July 29, 1949 (age 75 years, 229 days)
* Jill Biden (2009–2017) Born (1951-06-03)June 3, 1951 (age 73 years, 285 days)
* Karen Pence (2017–2021) Born (1957-01-01)January 1, 1957 (age 68 years, 73 days)
* Doug Emhoff (2021–2025) Born (1964-10-13)October 13, 1964 (age 60 years, 153 days)
* Usha Vance (2025–present) Born (1986-01-06)January 6, 1986 (age 39 years, 68 days)

## Causes and initiatives

* Joan Mondale: Art
* Barbara Bush: Literacy
* Marilyn Quayle: Early diagnosis of breast cancer
* Tipper Gore: Removing objectionable materials in popular American entertainment
* Lynne Cheney: History of the United States
* Jill Biden: "Joining Forces"; military families
* Karen Pence: Art therapy; military families
* Doug Emhoff: Food security; climate change; combatting antisemitism

## List of second ladies and gentlemen of the United States

| Image | Second Lady or Gentleman | Vice President Marriage date | Tenure | Date of birth | Date of death (age) | Tenure as First Lady |
| | Adams, Abigail Abigail Adams (née Abigail Smith) | Adams, John John Adams October 25, 1764 | April 21, 1789 – March 4, 1797 | (1744-11-22)November 22, 1744 | (1818-10-28)(1818-10-28)October 28, 1818 (73 years, 340 days) | 1797–1801 |
| 01.1 Vacant; Jefferson, Thomas Thomas Jefferson was a widower. | 01.1 Vacant; Jefferson, Thomas Thomas Jefferson was a widower. | 01.1 Vacant; Jefferson, Thomas Thomas Jefferson was a widower. | March 4, 1797 – March 4, 1801 | | | |
| 01.2 Vacant; Aaron Burr was a widower. | 01.2 Vacant; Aaron Burr was a widower. | 01.2 Vacant; Aaron Burr was a widower. | March 4, 1801 – March 4, 1805 | | | |
| 01.3 Vacant; George Clinton was a widower. | 01.3 Vacant; George Clinton was a widower. | 01.3 Vacant; George Clinton was a widower. | March 4, 1805 – April 20, 1812 | | | |
| 01.4 Vacant; no vice president after Clinton's death. | 01.4 Vacant; no vice president after Clinton's death. | 01.4 Vacant; no vice president after Clinton's death. | April 20, 1812 – March 4, 1813 | | | |
| | Gerry, Ann Ann Gerry (née Ann Thompson) | Gerry, Elbridge Elbridge Gerry January 12, 1786 | March 4, 1813 – November 23, 1814 | (1763-08-12)August 12, 1763 | (1849-03-17)March 17, 1849(1849-03-17) (aged 85) | |
| 02.1 Vacant; no vice president after Gerry's death. | 02.1 Vacant; no vice president after Gerry's death. | 02.1 Vacant; no vice president after Gerry's death. | November 23, 1814 – March 4, 1817 | | | |
| | Tompkins, Hannah Hannah Tompkins (née Hannah Minthorne) | Tompkins, Daniel D Daniel D Tompkins February 20, 1798 | March 4, 1817 – March 4, 1825 | (1781-08-28)August 28, 1781 | (1829-02-18)February 18, 1829(1829-02-18) (aged 47) | |
| | Calhoun, Floride Floride Bonneau Calhoun (née Floride Bonneau Colhoun) | Calhoun, John C. John C. Calhoun January 8, 1811 | March 4, 1825 – December 28, 1832 | (1792-02-15)February 15, 1792 | (1866-07-25)July 25, 1866(1866-07-25) (aged 74) | |
| 04.1 Vacant; no vice president after Calhoun's resignation. | 04.1 Vacant; no vice president after Calhoun's resignation. | 04.1 Vacant; no vice president after Calhoun's resignation. | December 28, 1832 – March 4, 1833 | | | |
| 04.2 Vacant; Buren, Martin Van Martin Van Buren was a widower. | 04.2 Vacant; Buren, Martin Van Martin Van Buren was a widower. | 04.2 Vacant; Buren, Martin Van Martin Van Buren was a widower. | March 4, 1833 – March 4, 1837 | | | |
| 04.3 Vacant; Johnson, Richard Mentor Richard M. Johnson was a widower | 04.3 Vacant; Johnson, Richard Mentor Richard M. Johnson was a widower | 04.3 Vacant; Johnson, Richard Mentor Richard M. Johnson was a widower | March 4, 1837 – March 4, 1841 | | | |
| | Tyler, Letitia Christian Letitia Tyler (née Letitia Christian) | Tyler, John John Tyler March 29, 1813 | March 4, 1841 – April 4, 1841 | (1790-11-12)November 12, 1790 | (1842-09-12)September 12, 1842(1842-09-12) (aged 51) | 1841–1842 |
| 05.1 Vacant; no vice president after Tyler assumed presidency. | 05.1 Vacant; no vice president after Tyler assumed presidency. | 05.1 Vacant; no vice president after Tyler assumed presidency. | April 4, 1841 – March 4, 1845 | | | |
| | Dallas, Sophia Sophia Dallas (née Sophia Chew Nicklin) | Dallas, George M. George M. Dallas May 23, 1816 | March 4, 1845 – March 4, 1849 | (1798-06-24)June 24, 1798 | (1869-01-11)January 11, 1869(1869-01-11) (aged 70) | |
| | Fillmore, Abigail Abigail Fillmore (née Abigail Powers) | Fillmore, Millard Millard Fillmore February 5, 1826 | March 4, 1849 – July 9, 1850 | (1798-03-13)March 13, 1798 | (1853-03-30)March 30, 1853(1853-03-30) (aged 55) | 1850–1853 |
| 07.1 Vacant; no vice president after Fillmore assumed presidency. | 07.1 Vacant; no vice president after Fillmore assumed presidency. | 07.1 Vacant; no vice president after Fillmore assumed presidency. | July 9, 1850 – March 4, 1853 | | | |
| Vacant; William R. King was unmarried. | Vacant; William R. King was unmarried. | Vacant; William R. King was unmarried. | March 4, 1853 – April 18, 1853 | | | |
| 02.1 Vacant; no vice president after King’s death. | 02.1 Vacant; no vice president after King’s death. | 02.1 Vacant; no vice president after King’s death. | April 18, 1853 – March 4, 1857 | | | |
| | Breckinridge, Mary Cyrene Burch Mary Cyrene Burch Breckinridge (née Mary Cyrene Burch) | Breckinridge, John C. John C. Breckinridge December 12, 1843 | March 4, 1857 – March 4, 1861 | (1826-08-16)August 16, 1826 | (1907-10-08)October 8, 1907(1907-10-08) (aged 81) | |
| | Hamlin, Ellen Ellen Hamlin (née Ellen Vesta Emery) | Hamlin, Hannibal Hannibal Hamlin September 25, 1856 | March 4, 1861 – March 4, 1865 | (1835-09-14)September 14, 1835 | (1925-02-01)February 1, 1925(1925-02-01) (aged 89) | |
| | Johnson, Eliza Eliza McCardle Johnson (née Eliza McCardle) | Johnson, Andrew Andrew Johnson May 17, 1827 | March 4, 1865 – April 15, 1865 | (1810-10-04)October 4, 1810 | (1876-01-15)January 15, 1876(1876-01-15) (aged 65) | 1865–1869 |
| 10.1 Vacant; no vice president after Johnson assumed presidency. | 10.1 Vacant; no vice president after Johnson assumed presidency. | 10.1 Vacant; no vice president after Johnson assumed presidency. | April 15, 1865 – March 4, 1869 | | | |
| | Colfax, Ellen Maria Ellen Maria Colfax (née Ellen Maria Wade) | Colfax, Schuyler Schuyler Colfax November 18, 1868 | March 4, 1869 – March 4, 1873 | (1836-07-26)July 26, 1836 | (1911-03-04)March 4, 1911(1911-03-04) (aged 74) | |
| Vacant; Henry Wilson was a widower. | Vacant; Henry Wilson was a widower. | Vacant; Henry Wilson was a widower. | March 4, 1873 – November 22, 1875 | | | |
| 11.3 Vacant; Wheeler, William A. William A. Wheeler was a widower. | 11.3 Vacant; Wheeler, William A. William A. Wheeler was a widower. | 11.3 Vacant; Wheeler, William A. William A. Wheeler was a widower. | March 4, 1877 – March 4, 1881 | | | |
| 11.4 Vacant; Arthur, Chester A. Chester A. Arthur was a widower. | 11.4 Vacant; Arthur, Chester A. Chester A. Arthur was a widower. | 11.4 Vacant; Arthur, Chester A. Chester A. Arthur was a widower. | March 4, 1881 – September 19, 1881 | | | |
| 11.5 Vacant; no vice president after Arthur assumed presidency. | 11.5 Vacant; no vice president after Arthur assumed presidency. | 11.5 Vacant; no vice president after Arthur assumed presidency. | September 19, 1881 – March 4, 1885 | | | |
| | Hendricks, Eliza Eliza Hendricks (née Eliza Carol Morgan) | Hendricks, Thomas A. Thomas A. Hendricks September 26, 1845 | March 4, 1885 – November 25, 1885 | (1823-11-23)November 23, 1823 | (1903-01-03)November 3, 1903(1903-11-03) (aged 79) | |
| 12.1 Vacant; no vice president after Hendricks's death. | 12.1 Vacant; no vice president after Hendricks's death. | 12.1 Vacant; no vice president after Hendricks's death. | November 25, 1885 – March 4, 1889 | | | |
| | Morton, Anna Anna Morton (née Anna Livingston Reade Street) | Morton, Levi P. Levi P. Morton February 12, 1873 | March 4, 1889 – March 4, 1893 | (1846-05-18)May 18, 1846 | (1918-08-14)August 14, 1918(1918-08-14) (aged 72) | |
| | Stevenson, Letitia Letitia Stevenson (née Letitia Green) | Stevenson, Adlai I Adlai Stevenson I December 22, 1866 | March 4, 1893 – March 4, 1897 | (1843-01-08)January 8, 1843 | (1913-12-25)December 25, 1913(1913-12-25) (aged 70) | |
| | Hobart, Jennie Esther Jane "Jennie" Tuttle Hobart (née Esther Jane Tuttle) | Hobart, Garret Garret Hobart July 21, 1869 | March 4, 1897 – November 21, 1899 | (1849-04-30)April 30, 1849 | (1941-01-08)January 8, 1941(1941-01-08) (aged 91) | |
| 15.1 Vacant; no vice president after Hobart's death. | 15.1 Vacant; no vice president after Hobart's death. | 15.1 Vacant; no vice president after Hobart's death. | November 21, 1899 – March 4, 1901 | | | |
| | Roosevelt, Edith Edith Roosevelt (née Edith Kermit Carow) | Roosevelt, Theodore Theodore Roosevelt December 2, 1886 | March 4, 1901 – September 14, 1901 | (1861-08-06)August 6, 1861 | (1948-09-30)September 30, 1948(1948-09-30) (aged 87) | 1901–1909 |
| 16.1 Vacant; no vice president after Roosevelt assumed presidency. | 16.1 Vacant; no vice president after Roosevelt assumed presidency. | 16.1 Vacant; no vice president after Roosevelt assumed presidency. | September 14, 1901 – March 4, 1905 | | | |
| | Fairbanks, Cornelia Cornelia "Nellie" Cole Fairbanks (née Cornelia Cole) | Fairbanks, Charles W. Charles W. Fairbanks October 6, 1874 | March 4, 1905 – March 4, 1909 | (1852-01-14)January 14, 1852 | (1913-10-24)October 24, 1913(1913-10-24) (aged 61) | |
| | Sherman, Carrie Carrie Babcock Sherman (née Carrie Babcock) | Sherman, James S. James S. Sherman January 26, 1881 | March 4, 1909 – October 30, 1912 | (1856-11-16)November 16, 1856 | (1931-10-06)October 6, 1931(1931-10-06) (aged 74) | |
| 18.1 Vacant; no vice president after Sherman's death. | 18.1 Vacant; no vice president after Sherman's death. | 18.1 Vacant; no vice president after Sherman's death. | October 30, 1912 – March 4, 1913 | | | |
| | Marshall, Lois Irene Lois Irene Marshall (née Lois Irene Kimsey) | Marshall, Thomas R. Thomas R. Marshall October 2, 1895 | March 4, 1913 – March 4, 1921 | (1873-05-09)May 9, 1873 | (1958-01-06)January 6, 1958(1958-01-06) (aged 84) | |
| | Coolidge, Grace Grace Coolidge (née Grace Anna Goodhue) | Coolidge, Calvin Calvin Coolidge October 4, 1905 | March 4, 1921 – August 2, 1923 | (1879-01-03)January 3, 1879 | (1957-07-08)July 8, 1957(1957-07-08) (aged 78) | 1923–1929 |
| 20.1 Vacant; no vice president after Coolidge assumed presidency. | 20.1 Vacant; no vice president after Coolidge assumed presidency. | 20.1 Vacant; no vice president after Coolidge assumed presidency. | August 2, 1923 – March 4, 1925 | | | |
| | Dawes, Caro Caro Dawes (née Caro Dana Blymyer) | Dawes, Charles G. Charles G. Dawes January 24, 1889 | March 4, 1925 – March 4, 1929 | (1866-01-06)January 6, 1866 | (1957-10-03)October 3, 1957(1957-10-03) (aged 91) | |
| 21.1 Vacant; Curtis, Charles Charles Curtis was a widower. | 21.1 Vacant; Curtis, Charles Charles Curtis was a widower. | 21.1 Vacant; Curtis, Charles Charles Curtis was a widower. | March 4, 1929 – March 4, 1933 | | | |
| | Garner, Mariette Mariette Elizabeth "Ettie" Garner (née Mariette Elizabeth Rheiner) | Garner, John Nance John Nance Garner November 25, 1895 | March 4, 1933 – January 20, 1941 | (1869-07-17)July 17, 1869 | (1948-08-17)August 17, 1948(1948-08-17) (aged 79) | |
| | Wallace, Ilo Ilo Wallace (née Ilo Browne) | Wallace, Henry A. Henry A. Wallace May 20, 1914 | January 20, 1941 – January 20, 1945 | (1888-03-10)March 10, 1888 | (1981-02-22)February 22, 1981(1981-02-22) (aged 92) | |
| | Truman, Bess Bess Truman (née Elizabeth Virginia Wallace) | Truman, Harry S. Harry S. Truman June 28, 1919 | January 20, 1945 – April 12, 1945 | (1885-02-13)February 13, 1885 | (1982-10-18)October 18, 1982(1982-10-18) (aged 97) | 1945–1953 |
| 24.1 Vacant; no vice president after Truman assumed presidency. | 24.1 Vacant; no vice president after Truman assumed presidency. | 24.1 Vacant; no vice president after Truman assumed presidency. | April 12, 1945 – January 20, 1949 | | | |
| 24.2 Vacant; Barkley, Alben W. Alben W. Barkley was a widower. | 24.2 Vacant; Barkley, Alben W. Alben W. Barkley was a widower. | 24.2 Vacant; Barkley, Alben W. Alben W. Barkley was a widower. | January 20, 1949 – November 18, 1949 | | | |
| | Barkley, Jane Hadley Jane Hadley Barkley (née Elizabeth Jane Rucker) | Barkley, Alben W. Alben W. Barkley November 18, 1949 | November 18, 1949 – January 20, 1953 | (1911-09-23)September 23, 1911 | (1964-09-06)September 6, 1964(1964-09-06) (aged 52) | |
| | Nixon, Pat Pat Nixon (née Thelma Catherine Ryan) | Nixon, Richard Richard Nixon June 21, 1940 | January 20, 1953 – January 20, 1961 | (1912-03-16)March 16, 1912 | (1993-06-22)June 22, 1993(1993-06-22) (aged 81) | 1969–1974 |
| | Johnson, Lady Bird Claudia "Lady Bird" Johnson (née Claudia Alta Taylor) | Johnson, Lyndon B. Lyndon B. Johnson November 17, 1934 | January 20, 1961 – November 22, 1963 | (1912-12-22)December 22, 1912 | (2007-07-11)July 11, 2007(2007-07-11) (aged 94) | 1963–1969 |
| 27.1 Vacant; no vice president after Johnson assumed presidency. | 27.1 Vacant; no vice president after Johnson assumed presidency. | 27.1 Vacant; no vice president after Johnson assumed presidency. | November 22, 1963 – January 20, 1965 | | | |
| | Humphrey, Muriel Muriel Humphrey Brown (née Muriel Fay Buck) | Humphrey, Hubert Hubert Humphrey September 3, 1936 | January 20, 1965 – January 20, 1969 | (1912-02-20)February 20, 1912 | (1998-09-20)September 20, 1998(1998-09-20) (aged 86) | |
| | Agnew, Judy Elinor "Judy" Agnew (née Elinor Isabel Judefind) | Agnew, Spiro Spiro Agnew May 27, 1942 | January 20, 1969 – October 10, 1973 | (1921-04-23)April 23, 1921 | (2012-06-20)June 20, 2012(2012-06-20) (aged 91) | |
| 30.1 Vacant; no vice president until Ford's confirmation under the 25th Amendment. | 30.1 Vacant; no vice president until Ford's confirmation under the 25th Amendment. | 30.1 Vacant; no vice president until Ford's confirmation under the 25th Amendment. | October 10, 1973 – December 6, 1973 | | | |
| | Ford, Betty Elizabeth "Betty" Ford (née Elizabeth Anne Bloomer) | Ford, Gerald Gerald Ford October 15, 1948 | December 6, 1973 – August 9, 1974 | (1918-04-08)April 8, 1918 | (2011-07-08)July 8, 2011(2011-07-08) (aged 93) | 1974–1977 |
| 30.1 Vacant; no vice president until Rockefeller's confirmation under the 25th Amendment. | 30.1 Vacant; no vice president until Rockefeller's confirmation under the 25th Amendment. | 30.1 Vacant; no vice president until Rockefeller's confirmation under the 25th Amendment. | August 9, 1974 – December 19, 1974 | | | |
| | Rockefeller, Happy Margaretta "Happy" Rockefeller (née Margaretta Large Fitler) | Rockefeller, Nelson Nelson Rockefeller May 4, 1963 | December 19, 1974 – January 20, 1977 | (1926-06-09)June 9, 1926 | (2015-05-19)May 19, 2015(2015-05-19) (aged 88) | |
| | Mondale, Joan Joan Mondale (née Joan Adams) | Mondale, Walter Walter Mondale December 27, 1955 | January 20, 1977 – January 20, 1981 | (1930-08-08)August 8, 1930 | (2014-02-03)February 3, 2014(2014-02-03) (aged 83) | |
| | Bush, Barbara Barbara Bush (née Barbara Pierce) | Bush, George H. W. George H. W. Bush January 6, 1945 | January 20, 1981 – January 20, 1989 | (1925-06-08)June 8, 1925 | (2018-04-17)April 17, 2018(2018-04-17) (aged 92) | 1989–1993 |
| | Quayle, Marilyn Marilyn Quayle (née Marilyn Tucker) | Quayle, Dan Dan Quayle November 18, 1972 | January 20, 1989 – January 20, 1993 | (1949-07-29)July 29, 1949 | 2025-03-15 Living 75 years, 229 days | |
| | Gore, Tipper Mary Elizabeth "Tipper" Gore (née Mary Elizabeth Aitcheson) | Gore, Al Al Gore May 19, 1970 | January 20, 1993 – January 20, 2001 | (1948-08-19)August 19, 1948 | 2025-03-15 Living 76 years, 208 days | |
| | Cheney, Lynne Lynne Cheney (née Lynne Ann Vincent) | Cheney, Dick Dick Cheney August 29, 1964 | January 20, 2001 – January 20, 2009 | (1941-08-14)August 14, 1941 | 2025-03-15 Living 83 years, 213 days | |
| | Biden, Jill Jill Biden (née Jill Tracy Jacobs) | Biden, Joe Joe Biden June 17, 1977 | January 20, 2009 – January 20, 2017 | (1951-06-03)June 3, 1951 | 2025-03-15 Living 73 years, 285 days | 2021–2025 |
| | Pence, KarenKaren Pence (née Karen Sue Batten) | Pence, MikeMike Pence June 8, 1985 | January 20, 2017 – January 20, 2021 | (1957-01-01)January 1, 1957 | 2025-03-15Living 68 years, 73 days | |
| | Emhoff, DouglasDouglas Craig Emhoff | Harris, KamalaKamala Harris August 22, 2014 | January 20, 2021 – January 20, 2025 | (1964-10-13)October 13, 1964 | 2025-03-15Living 60 years, 153 days | |
| | Vance, UshaUsha Vance (née Usha Bala Chilukuri) | Vance, JDJD Vance June 14, 2014 | January 20, 2025 – present | (1986-01-06)January 6, 1986 | 2025-03-15Living 39 years, 68 days | |

## Other spouses of U.S. vice presidents

Various other spouses of vice presidents of the United States are not considered as second ladies of the United States because their marriages were not during the vice presidential terms of their husbands.
Nine U.S. vice presidents were widowed prior to their vice presidencies:
* Thomas Jefferson was married to Martha Wayles from 1772 until her death in 1782.
* Aaron Burr was married to Theodosia Bartow Prevost from 1782 until her death in 1794.
* George Clinton was married to Sarah Tappen from 1770 until her death in 1800.
* Martin Van Buren was married to Hannah Hoes from 1807 until her death in 1819.
* Richard Mentor Johnson deemed the enslaved Julia Chinn to be his common-law wife until her death in 1830.
* Henry Wilson was married to Harriet Howe from 1840 until her death in 1870.
* William A. Wheeler was married to Mary King from 1845 until her death in 1876.
* Chester A. Arthur was married to Ellen Lewis Herndon from 1859 until her death in 1880.
* Charles Curtis was married to Annie Baird from 1884 until her death in 1924. Curtis's half-sister Dolly Gann acted as his official hostess for social events during his vice presidency.
Five U.S. vice presidents were widowed and remarried prior to their vice presidencies:
* Hannibal Hamlin was married to Sarah Emery from 1833 until her death in 1855. He was subsequently married to Ellen Emery from 1856 to his death in 1891.
* Schuyler Colfax was married to Evelyn Clark from 1844 until her death in 1863. He was subsequently married to Ellen Wade from 1868 to his death in 1885.
* Levi P. Morton was married to Lucy Young Kimball from 1856 until her death in 1871. He was subsequently married to Anna Livingston Reade Street from 1873 to her death in 1918.
* Theodore Roosevelt was married to Alice Hathaway Lee from 1880 until her death in 1884. He was subsequently married to Edith Carow from 1886 to his death in 1919.
* Joe Biden was married to Neilia Hunter from 1966 until her death in 1972. He has subsequently been married to Jill Jacobs since 1977.
One U.S. vice president was divorced and remarried prior to his vice presidency:
* Nelson Rockefeller was married to Mary Todhunter Clark from 1930 until 1962. He was subsequently married to Happy Fitler Murphy from 1963 until his death in 1979.
One U.S. vice president was widowed before his vice presidency and remarried during his vice presidency:
* Alben W. Barkley was married to Dorothy Brower from 1903 until her death in 1947. He was subsequently married to Jane Rucker Hadley from 1949 to his death in 1956.
Three U.S. vice presidents remarried after their vice presidencies:
* Aaron Burr was married to Elizabeth Bowen Jumel from 1833 until their divorce in 1836.
* John Tyler was married to Julia Gardiner from 1844 until his death in 1862.
* Millard Fillmore was married to Caroline Carmichael McIntosh from 1858 until his death in 1874.