# Amit Singh (scientist)

Amit Singh is an Indian microbiologist in the Department of Microbiology & Cell Biology at the Indian Institute of Science. His chief area of research is pathogenesis, especially drug resistance. He has focused on measuring drug resistant mechanisms in both mycobacterium tuberculosis (TB) and human immunodeficiency viruses (HIV).

## Biography

Amit Singh was born on March 18, 1976. He earned a bachelor's degree in science from the University of Delhi and a master's degree in biotechnology from the Indian Institute of Technology Roorkee in 1998. He subsequently obtained a PhD in 2004 under the guidance of Anil Kumar Tyagi at the South Campus at the University of Delhi and moved to the US for postdoctoral training at the University of Alabama in Birmingham, working in the lab of Dr. Adrie JC Steyn.
After returning to India in 2010, Singh served as a Wellcome Trust-DBT Intermediate Fellow with the International Centre for Genetic Engineering and Biotechnology. In January 2014, he joined the Indian Institute of Science (IISc) in their department of microbiology and cell biology, where he holds the position of associate professor. He heads the Centre for Infectious Disease Research as its group leader, hosting several researchers who conduct research on the mechanisms of chronic human infections with a special focus on Mycobacterium tuberculosis and human immunodeficiency virus (HIV).

## Awards

Singh has been a Wellcome Trust-DBT Senior Fellow since 2016. The Department of Biotechnology of the Government of India awarded him the 2017/18 National Bioscience Award for Career Development.
In 2021, Singh was awarded the Shanti Swarup Bhatnagar award for research, which cited his "outstanding contributions to our fundamental understanding of host-pathogen interaction in Mycobacterium tuberculosis and HIV, the causative viral agent of human acquired immunodeficiency syndrome (AIDS)". Singh was recognized on the Asian Scientist 100 in 2022.

## Publications
### Most cited articles at University of Alabama

* Singh, A; Crossman, DK; Mai, D; Guidry, L; Voskuil, MI; Renfrow, MB; Steyn, AJ (2009). "Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response". PLOS Pathog. 5 (8): e1000545. doi:10.1371/journal.ppat.1000545. PMC 2718811. PMID 19680450. (Cited by 204 articles according to Google Scholar.)
* Singh, A; Guidry, L; Narasimhulu, KV; Mai, D; Trombley, J; Redding, KE; Giles, GI; Lancaster, JR Jr; Steyn, AJ (2007). "Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival". Proc Natl Acad Sci U S A. 104 (28): 11562–7. Bibcode:2007PNAS..10411562S. doi:10.1073/pnas.0700490104. PMC 1906726. PMID 17609386. (Cited by 154 articles according to Google Scholar.)

### Most cited articles at IISc

* Ashima Bhaskar, Manbeena Chawla, Mansi Mehta, Pankti Parikh, Pallavi Chandra, Devayani Bhave, Dhiraj Kumar, Kate S Carroll, Amit Singh. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. 2014. PLOS Pathogens. 10:1 e1003902. (Cited by 88 articles according to Google Scholar.)
* Rufai SB, Kumar P, Singh A, Prajapati S, Balooni V, Singh S. Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis. Journal of clinical microbiology. 2014 June; 52 (6): 1846–52. (Cited by 76 articles according to Google Scholar.)
* Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D. Adrie JC Steyn and Amit Singh. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Molecular microbiology. 2012 September; 85 (6): 1148–65. (Cited by 56 articles according to Google Scholar.)