OpenLLM-France/wikimedia huggingface dataset:
# Theta defensin

Theta-defensins (θ-defensins, retrocyclins, or demidefensins) are a family of mammalian antimicrobial peptides. They are found in non-human 'Old World' primates, but not in human, gorilla, bonobo, and chimpanzee.

## Structure

θ-defensins are cyclic peptides of 18 amino acids (~2 kDa), possessing antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, fungi, and some retroviruses. They consist of a pair of antiparallel β-sheets linked by three disulfide bonds arranged as a ladder along the sheets to form an extremely stable structure. Additionally, the peptides may self-associate into trimers.

## Biosynthesis

In rhesus macaque (Macaca mulatta) and olive baboon (Papio anubis), θ-defensins are produced from precursor proteins with 76 amino acids each. A single nine amino acid peptide is derived from each precursor. Two of these nine amino acid peptides are spliced together to form the circular 18 amino acid defensin. Since there are two precursor genes (rhesus theta defensin RTD-1 and RTD-2) they can form 3 different mature θ-defensins: the homodimer of processed RTD-1, The homodimer of processed RTD-2 or the heterodimer composed of both precursors. The heterodimeric form is the most abundant.
In the olive baboon, four θ-defensin precursor genes have been isolated: BTD-a, BTD-b, BTD-c and BTD-d, which encode subunits A, B, C and D. These four subunits could theoretically combine to produce 10 different processed defensins. However, only five have been observed: consisting of subunits A+A, A+B, A+C, A+D and B+B (Referred to as BTD-3, BTD-1, BTD-4, BTD7 and BTD-2 respectively). Finally, orangutan genomes encode 4 θ-defensin precursor genes and gibbon genomes encode 2.

## Activity

Antimicrobial activity has been reported against bacteria, fungi, enveloped viruses, and protozoa. Antimicrobial activity is generally through binding to and disrupting the cell membrane. Antiviral activity appears to derive from their binding to the sugar component of glycoproteins and blocking the entry of viruses into the cell.

## Evolution
### Genesis

θ-defensins are extremely divergent members of the defensin protein superfamily which includes alpha-, beta- and big-defensins. The θ-defensins appear to have evolved from α-defensin genes around 40 million years ago in Old World monkeys. Compared to their α-defensin ancestors, θ-defensin genes are truncated into two halves.

### Inactivaton

Although New World monkeys and great apes do not produce θ-defensin proteins, their genomes do encode θ-defensin genes which are transcribed to mRNA but not translated due to a premature stop codon. When the mature defensin that would be expressed is chemically synthesised in a laboratory, it shows antimicrobial activity (including anti-retrovirus, leading to the name "retrocyclin"). It is unknown whether this pseudogenisation gave a selective advantage or was due to genetic drift. The anti-HIV activity of retrocyclins has been further enhanced by protein engineering efforts with the aim of generating a viable treatment.
# Margot Grimmer

Margot Grimmer (born 1944) rose to prominence as a dancer in several companies, including the Lyric Opera Ballet, the Ruth Page International Ballet, the New York City Ballet, and the Ballet Russe de Monte Carlo. She studied ballet as a child in Chicago, and was among 50 from 3,000 applicants selected for the children’s ensemble of the New York City Ballet’s Chicago production of George Balanchine’s Nutcracker at the Opera House. At age 14, she danced professionally in Broadway musicals at the Kansas City Starlight Theatre and continued at the St. Louis Municipal Theatre and Music Theater in Highland Park. After high school, Grimmer’s career flourished. In 1962, she appeared with Ruth Page’s Chicago Opera Ballet in the American debut of Russian defector superstar Rudolf Nureyev at the Brooklyn Academy of Music. In 1965, she danced a principal role in the Lyric Opera of Chicago’s production of Carmina Burana at the Opera House. From 1965-1968, she performed in the International Ballet’s Nutcracker, starring Erik Bruhn, Carla Fracci, Henning Kronstam and Kirsten Simone, at McCormick Place and the Opera House. From 1965-1968, she gave lecture-demonstration performances in ballet and modern dance, under a federal grant from the National Endowment for Arts, for the War On Poverty’s Cultural Enrichment program in Chicago’s inner city schools. In 1967, she was featured in the experimental dance movie Statics, which won awards in cinematography and art direction at International Film Festivals. On off-seasons, she attended Northwestern University, majoring in acting and English Literature.
In 1970, Grimmer became director of the Eric Braun School of Dance in Highland Park after the American Ballet Theatre star’s untimely death. She began teaching, inspiring and mentoring young dancers. In 1972, she founded the American Dance Company after receiving standing ovations and critical acclaim at the Chicago premiere of her rock ballet In-A-Gadda-Da-Vida. The Company presented original ballets, many of them recipients of grants from the Illinois Arts Council and the National Endowment for Arts. Grimmer became well known for her commitment toward creating progressive ballets, choosing to choreograph multimedia presentations, blending the precision of classical ballet with the earthiness of modern dance and the theatrical flash of jazz. She appeared on Chicago Ballet Guild Choreographers’ Showcase performances throughout Illinois from 1972-1975, at the Ravinia Festival in 1973, with the Chicago Symphony Orchestra in 1974, on the Bob Hope Show at the Milwaukee Auditorium in 1975, at the Kennedy Center in 1976, on the Weinstein Center for Performing Arts concert series from 1975-1987 and at the Chicago Daley Center and Cultural Center from 1978-1987.
She is listed in the Who’s Who of American Women, the International Who’s Who of Intellectuals and Who’s Who in America. Photos and memorabilia of her career are included in the Ann Barzel Dance Archives of the Newberry Library in Chicago. Her dance career memoir, An American Dance Story, was published in 2020.
# Montague Street

Montague Street may be:
* Montague Street, London, England
* Montague Street, Melbourne, Victoria, Australia; noted for the Montague Street Bridge
* Montague Street, Brooklyn Heights, New York, United States; location of several city-landmarked buildings including the Brooklyn Trust Company Building
# Kodak Ektaprint Electronic Publishing System

The Kodak Ektaprint Electronic Publishing System (KEEPS) was a professional electronic publishing system sold internationally by the Eastman Kodak Company from 1987–1992. KEEPS was a fully integrated turnkey system, consisting of publishing software from Interleaf, computer hardware from Sun Microsystems, customized front-end software developed by Kodak that ran on Unix System V Release 4, and Kodak's high-end scanners (which were designed in-house) and Ektaprint printers and copiers (which were actually Heidelberg-engined machines).
KEEPS was capable of producing WYSIWYG ("what you see is what you get") output at near-typeset quality, while also offering document management and workflow tools for collaborative environments.
Marketing materials from Kodak distinguished KEEPs from Desktop Publishing by describing the product as Professional Electronic Publishing.
KEEPS became the preferred document publishing system from 1989–1990 amongst governments and large corporations.

## History

During its inception in the early 1980s, Eastman Kodak Company put together a specialized division to sell and maintain KEEPS. Kodak bought the rights to the Atek Publishing System in the early 1980s. At the time of acquisition, Atek was the leading publishing software product for newspapers and magazines.
Kodak established contracts with Sun Microsystems which allowed it to sell workstation and server equipment for less money than Sun itself could sell it for. The arrangement was made possible by Kodak agreeing to provide installation, service and support of the hardware themselves.
In the early stages of KEEPS's product life cycle, Kodak had a significant advantage in making sales to the federal government which (at that time) preferred doing business with older established companies—especially since Kodak already had a substantial presence in government with its copiers, film, and other technology, and could leverage government contacts and contracts into new business.
At first, Kodak hired representatives (both sales/marketing and technicians) who had extensive knowledge of the publishing industry, and promised them competitive salaries.
KEEPS's popularity peaked in 1990, prior to the release of the Quark Publishing System, Arbortext, and Framemaker and during the infancies of Xerox Ventura Publisher and Aldus Pagemaker.
Later, Kodak reneged on the salary promises they made, and slowly began losing division staff to competitors offering better salaries, including Interleaf, Frame Technology Corp, Arbortext, etc.
Kodak renamed its KEEPS publishing and copier line to Lionheart. By then, the division lost most of the people who really understood the product and the publishing industry. Lionheart was discontinued after Interleaf announced a new version of their product (Interleaf 5) which would run on PCs. In 1991, Quark released a viable product suitable for collaborative environments, and Ventura Publisher and Pagemaker became serious competitors.
# PLCB4

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.

## Function

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.
# The Cure for Death by Lightning

The Cure for Death by Lightning is the debut novel from Canadian author Gail Anderson-Dargatz. It was nominated for the Giller Prize, was awarded the Ethel Wilson Fiction Prize, and became a bestseller in Canada (selling over 100,000 copies) and Great Britain (where it won a Betty Trask Award).

## Plot introduction

Set in an isolated farming community in Shuswap Country, British Columbia at the end of the Second World War it is a coming of age story containing elements of magic realism. Fifteen-year-old Beth Weeks has to contend with her family's struggle against poverty but also her increasingly paranoid and aggressive father whose behaviour leaves the family as outcasts in the community. A number of unusual characters appear in the book, including Filthy Billy, a hired hand with tourettes and Nora, a sensual half-Native girl whose mother has an extra little finger and a man's voice.
The title of the book comes from one of a number of household tips and recipes belonging to her mother which appear as asides throughout the book, while Beth's mother withdraws from reality and talks with her dead mother; leaving Beth to be sexually molested by her father.

## Reception

* The Boston Sunday Globe described how, "some first novelists tiptoe. Not Gail Anderson-Dargatz. She makes her debut in full stride, confidently breaking the rules to create a fictional style we might call Pacific Northwest Gothic."
* Canadian Literature quarterly criticizes the "somewhat ponderous plot" but praises the "acuteness of vision" and "sharp rendition of the breathless, sensate moment" as the "magic in the ordinary" is revealed.
# Perry County Courthouse

Perry County Courthouse may refer to:
* Perry County Courthouse (Arkansas), Perryville, Arkansas
* Perry County Courthouse (Illinois), Pinckneyville, Illinois
* Old Perry County Courthouse (Indiana), Rome, Indiana
* Perry County Courthouse (Mississippi), New Augusta, Mississippi, a Mississippi Landmark
* Perry County Courthouse (Missouri), Perryville, Missouri
* Perry County Courthouse (Ohio), New Lexington, Ohio
* Old Perry County Courthouse (Ohio), Somserset, Ohio
* Perry County Courthouse (Pennsylvania), New Bloomfield, Pennsylvania
* Perry County Courthouse (Tennessee), Linden, Tennessee
# Tuba Hassan

Tuba Hassan (born 18 October 2000) is a Pakistani cricketer who plays as a right-arm leg break bowler. She has also played domestic cricket for Lahore, Higher Education Commission and Quetta.
In January 2022, she was named as a reserve player in Pakistan's squad for the 2022 Women's Cricket World Cup. In May 2022, she was named in both the Women's Twenty20 International (WT20I) and Women's One Day International (WODI) squads for Sri Lanka's tour of Pakistan.

## International career

Hassan made her international debut in the first WT20I on 24 May 2022, in which she took the best bowling figures for a Pakistani debutant, with 3/8 from her four overs. Later the same month, she was named in Pakistan's team for the cricket tournament at the 2022 Commonwealth Games in Birmingham, England. Following her performance on her debut, she won the ICC Women's Player of the Month award ahead of teammate Bismah Maroof and Jersey player Trinity Smith, becoming the first women from the Pakistan team to win it. In July 2022, the Pakistan Cricket Board (PCB) awarded her with her first central contract.
Hassan made her ODI debut against Australia on 21 January 2023.
She was named in the Pakistan squad for the 2024 ICC Women's T20 World Cup.
# Matt Aldridge

Matthew Aldridge (born 11 March 1996) is a British rower.

## Career

Aldridge won the gold medal in the coxless four at the 2022 European Rowing Championships.
In 2023, he won the Stewards' Challenge Cup at the Henley Royal Regatta, rowing for the Oxford Brookes University Boat Club. Later that year, he won a World Championship gold medal in the men's coxless four, at the 2023 World Rowing Championships in Belgrade.
# Tibetan Welfare Office

The Tibetan Settlement Office (T.S.O.) (formerly "Tibetan Welfare Office") Tibetan: ང་ཚོའི་སྐོར།, Wylie: nga tsho'i skor is acting within the Tibetan Ministry of the Interior and is part of the central Tibetan administration in Dharmshala, India. The T.S.O. organizes projects in the social, cultural and economical sectors. Furthermore, they focus on issues of environment and enduring development.

## Waste Management

In 1994 the "Clean Upper Dharmshala“-project was launched by the T.S.O. The aim was to solve the waste management in Upper Dharmshala which needed strong efforts due to the increase of nonbiodegradable waste in that region.
In the beginning the project had installed three „Green Workers“, who collected recyclable material from companies and households in McLeod Ganj. A great positive impact on the environmental situation could also be achieved by installing five dustbins which were frequently emptied by a dust cart.
Furthermore, public toilets were built, which are frequently being maintained. The drainage system in the area of McLeod Ganj and the Dal Lake was displaced to prevent water pollution.

## Recycling

Recyclable material is being collected door by door by the "Green Workers" or emitted by the households.
The following materials are being recycled:
* soft plastics (i.e. plastic bags)
* hard plastics (cassettes, ballpoint pens, packages,...)
* glass bottles, cullet
* carton
* clothes and shoes
* tin and other metals
The collected material is either sold in Dharmshala or transported to Pathankot (distance: 80 kilometres). The transportation itself is not cost-effective.

## Paper Factory

The T.S.O. opened a little paper factory in Upper Dharmshala where handmade products are made by recycling paper.

## The Green Shop

In 1994 "The Green Shop“ was opened and is an environmentally oriented shop selling various products and acts as a collection point for hazardous materials, such as used batteries and expired medicines.
Furthermore, the following products are sold:
* clean water
* paper products from the paper factory
* bags
* ecological shampoos and conditioners
* soaps and crèmes
* Tibetan tea

## Social Commitment

The Tibetan Settlement Office is concerned about the needs of the society. It tries to find various solutions by questioning youth, education, and old-age provision. The T.S.O. is also giving legal advice in cases of conflicts in the society. One of its main goals is to obtain a social, religious and political harmony within the society.
The T.S.O. also established the „Gaddi Women's Self-Help Society“.
Since 2003, the Tibetan Settlement Office is a partner of Austrian Service Abroad, with one Austrian Social Servant (usually) per year working here for ten months.
# Pepco Holdings

Pepco Holdings was a holding company incorporated in February 2001 for the purpose of effecting the acquisition of Conectiv Power Delivery by Potomac Electric Power Company (better known as "Pepco"). The acquisition was completed on August 1, 2002, at which time Pepco and Conectiv became wholly owned subsidiaries of PHI. Conectiv itself had been formed in 1998 to be the holding company of Delmarva Power & Light Company (DPL, better known as "Delmarva Power") and Atlantic City Electric Company (ACE) in connection with the combination of DPL and ACE. In 2005, PHI resumed the use of the Delmarva Power and ACE brands for purposes of operations, with the result that Conectiv Energy was the only remaining Conectiv brand and was restricted for PHI's energy production facilities. Operations of the various companies controlled by Pepco Holdings take place in the Mid-Atlantic states of the United States. Pepco serves Washington, D.C., and its Maryland suburbs, Delmarva Power serves the Delaware and Maryland portions of the Delmarva Peninsula, and Atlantic City Electric serves South Jersey. In 2008, Delmarva Power sold its service area in the Virginia portion of the peninsula to A&N Electric Cooperative and Old Dominion Electric Cooperative for US$44 million. In April 2010, Conectiv Energy was sold to Calpine Corporation.
Pepco Holdings was placed at 283rd on the 2006 Fortune 500, a list of American companies ranked by gross revenue. In 2010, the company paid only 10% of the taxes it had paid in the previous year, dropping from $104 million to $11 million. The company experienced a doubling of operating profit in 2011, in part due to approved utility rate increases in the states of Delaware, Maryland, and New Jersey along with Washington, D.C.

## Merger with Exelon

Exelon announced the proposed purchase of Pepco Holdings, Inc on April 30, 2014. The merger was rejected by the District of Columbia Public Service Commission in August 2015, though it was approved by other federal and state regulators. On March 23, 2016, the merger with Exelon was approved by the District of Columbia Public Service Commission, under a revised set of terms. The merger was completed on that same day.

## Criticism

In December 2011, the non-partisan organization Public Campaign criticized Pepco Holdings for spending $3.76 million on lobbying and not paying any taxes during 2008–2010, instead getting $508 million in tax rebates, despite making a profit of $882 million and increasing executive pay by 118% to $9.7 million in 2010 for the top 5 executives.

## Restatement

In 2006, Pepco Holdings restated its previously reported consolidated financial statements for the three and six months ended June 30, 2005, to correct the accounting for certain deferred compensation arrangements.
# Pepducin

Pepducins are cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.
Pepducins employ lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways. A pepducin molecule consists of a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety. This structure allows pepducin lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein interface via a unique intracellular allosteric mechanism. Pepducins for over 15 different GPCRs have been successfully produced, several of which have shown activity in preclinical in vivo models.
An anti-PAR4 pepducin extended bleeding time in mice and protected against systemic platelet activation and thrombosis.
A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells.
A PAR1 pepducin, PZ-128, has successfully completed phase I clinical trials.
# Tidewater Tramp

Tidewater Tramp was a Canadian children's adventure television series which aired on CBC Television from 1959 to 1961.

## Premise

This Vancouver-produced series features the adventures of Captain Martin (Reg McReynolds) and his tramp steamer the Flying Kestrel. He carried cargo along the Inside Passage of British Columbia with the assistance of his daughter Gail (Maureen Cook) and coast cadet Peter (Robert William Chambers).
Most scenes were recorded in studio supplemented by location shots such as scenes from a British Columbia freighter.

## Scheduling

This half-hour series was broadcast Fridays at 5:00 p.m. (Eastern) from 2 October 1959 until 29 June 1962, omitting the season between March 1960 and October 1961.
# Persada Southwest Aceh

Persatuan Sepakbola Aceh Barat Daya (simply known as Persada Abdya or Persada) is an Indonesian football club based in Southwest Aceh Regency, Aceh. They currently compete in the Liga 3 and their homeground is Guhang Raya Stadium.
# Matthew Dixon

Matthew Dixon may refer to:
* Matthew Dixon (British Army officer) (1821–1905), recipient of the Victoria Cross
* Matthew Dixon (diver) (born 2000), English diver
* Matt Dixon (born 1992), Australian cricketer
* Matty Dixon (born 1994), English footballer
# Perimeceta niphotypa

Perimeceta niphotypa is a moth in the family Crambidae. It was described by Turner in 1915. It is found in Australia, where it has been recorded from New South Wales.
# Tunnel A1 (Ivan)

Tunnel A1 (Ivan) is a tunnel part of the A1 motorway in Bosnia and Herzegovina built by Autocesta FBiH. In January 2020 the first digging has been confirmed to have begun in the Herzegovina side of the tunnel. A total of 340,000,000 Euros (664,9 million KM) have been invested in the project to build the tunnel along with 11,4 million Euros for other expenses.
The project is part of newly built A1 motorway section Tarčin-Ivan.
The tunnel was expected to be completed by May 2022.
On October 31, 2022, following the completion of the Tarčin-Ivan motorway section, the tunnel opened along with the newly completed section.
# Perspectives on Sexual and Reproductive Health

Perspectives on Sexual and Reproductive Health was a bimonthly peer-reviewed medical journal covering reproductive health. It was established in 1969 as Family Planning Perspectives, obtaining its current name in 2002. It permanently ceased publication in 2020, alongside the Guttmacher Institute's other journal, International Perspectives on Sexual and Reproductive Health.
It was published by Wiley-Blackwell on behalf of the Guttmacher Institute. The final editor-in-chief was Dore Hollander. According to the Journal Citation Reports, the journal has a 2016 impact factor of 3.571, ranking it 1st out of 26 journals in the category "Demography" and 1st out of 43 journals in the category "Family studies."