# Daniel Trachsel

Daniel Trachsel is a Swiss chemist who studies psychedelics and entactogens. He has developed and published on a large number of novel psychedelic and entactogen compounds, including their psychoactive effects. This has been in a manner similar to that of the psychedelic chemist Alexander Shulgin, which has caused Trachsel to sometimes be referred to as the "German Shulgin". However, unlike Shulgin, Trachsel has distanced himself from any personal self-experiments.

## Compounds

Compounds that were first known to have been synthesized by Trachsel and colleagues include:
* 2C-BI-8
* 2C-CP
* 2C-Ph (2C-BI-1)
* 2C-T-3
* 2C-T-16
* 2C-T-21.5
* 2C-T-25
* 2C-T-27
* 2C-T-28
* 2C-T-30
* 2C-T-31
* 2C-T-32
* 2C-T-33
* 2C-TFE
* 2C-V
* 2C-YN
* 3C-DFE
* DFMDA
* Trifluoromescaline

## Selected publications
### Books

* Trachsel, D.; Richard, N. (2000). Psychedelische Chemie Aspekte psychoaktiver Moleküle [Psychedelic Chemistry: Aspects of Psychoactive Molecules] (in German) (1 ed.). Nachtschatten-Verlag. ISBN 978-3-907080-53-5. OCLC 247657972. Retrieved 31 January 2025. [Note: There are also several subsequent editions (2nd (2002) through 5th (2016)).]
* Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 31 January 2025.

### Papers

* Trachsel, Daniel (2002). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate" [Synthesis of new (phenylalkyl)amines for the investigation of structure-activity relationships, Communication 1, Mescaline derivatives] (PDF). Helvetica Chimica Acta. 85 (9): 3019–3026. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4.
* Trachsel, Daniel (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of new (phenylalkyl)amines for the investigation of structure–activity relationships. Communication 2: 4-thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzenethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN 0018-019X.
* Trachsel, Daniel (2003). "Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships, Part 3: 4-Ethynyl-2,5-dimethoxyphenethylamine (=4-Ethynyl-2,5-dimethoxybenzeneethanamine; 2C-YN)". Helvetica Chimica Acta. 86 (8): 2754–2759. doi:10.1002/hlca.200390224. ISSN 0018-019X.
* Trachsel D, Hadorn M, Baumberger F (March 2006). "Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives". Chem Biodivers. 3 (3): 326–336. doi:10.1002/cbdv.200690035. PMID 17193269.
* Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F (May 2009). "4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities". Chem Biodivers. 6 (5): 692–704. doi:10.1002/cbdv.200800235. PMID 19479848.
* Trachsel D (2012). "Fluorine in psychedelic phenethylamines". Drug Test Anal. 4 (7–8): 577–590. doi:10.1002/dta.413. PMID 22374819.
* Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)" (PDF). Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478.
* Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines" (PDF). Front Pharmacol. 12: 794254. doi:10.3389/fphar.2021.794254. PMC 8865417. PMID 35222010.
* Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (January 2023). "Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines" (PDF). Psychopharmacology (Berl). 240 (1): 115–126. doi:10.1007/s00213-022-06279-2. PMC 9816194. PMID 36477925.