OpenLLM-France/wikimedia huggingface dataset:
# Sunifiram

Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram (DM-232). Another analogue is sapunifiram (MN-19). As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world.

## Pharmacology

The mechanism of action of sunifiram is unknown. Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites. They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM. In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators. However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects. It is reported that sunifiram stimulates CaMKII and PKCα pathways, and that this action depends on the activation of glycine site of NMDA receptors.
Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (K$_i$ = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice. However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram.
# Henri Bandeken

Henri Bandeken Fong (born 14 February 1990) is a Cameroonian professional footballer who plays as a goalkeeper for Philippines Football League club One Taguig.

## Club career
### Early career

Bandeken played a large part of his early professional career in his home country of Cameroon, first with Vogt AC and later with Kousseri FC. In between, however, he played as keeper for Elite One club Canon Yaoundé, representing them in the CAF Champions League playoffs.

### United Football League

In 2015, he moved from Cameroon to sign with Stallion of the United Football League alongside Serge Kaole, playing with them for one season, finishing fifth. In 2016, he moved to Green Archers United.

### Philippines Football League

Bandeken would stay with Green Archers United for the Weekend Futbol League after the club declined to participate in the newly-formed PFL. However, he remained with the squad when they did join, keeping second-most clean sheets with 8.
He moved to new club Maharlika Manila in 2020 for their debut season, displaying more top-drawer performances.
In 2022, he moved to Mendiola 1991 for the upcoming 2022–23 season.

### Kaya–Iloilo

In 2023, after a short break, he would sign with PFL champions Kaya–Iloilo as a goalkeeping reinforcement for the 2023–24 AFC Champions League.

## International career

While playing football for Vogt AC, he was called up to the Cameroon national team for the 2007 CEMAC Cup in Chad, though the country did not send an official first-team but one composed of amateurs.
# Charlie Beaton

Charlie Yancy Larumbe Beaton (born 12 April 1995) is a Filipino professional footballer who plays as a midfielder for Loyola of the Philippines Football League and a former Philippine U23 National Team player.

## Club career
### Kaya FC

He joined Kaya FC for 2016 United Football League the seventh and last season of the league and the 2016 AFC Cup.

### Ilocos United

In 2017, Beaton joined the Ilocos United FC after playing for Kaya FC for almost a year.

### Maharlika Manila

Maharlika Manila signed Beaton from the suspended Global FC.

### Maharlika Manila

In 2023, Beaton return to Maharlika Manila FC.

### Stallion Laguna

Beaton joined Stallion for the 2023 Copa Paulino Alcantara.

### Loyola FC

In 2024, He return to his former club Loyola FC for the 2024 Philippines Football League season.

## Personal Life

Beaton was born to an English father and a Cebuana mother.

## International career
### Philippines U23

In 2016, Beaton was part of the Philippines U-23 squad.

## Honours
### Club

Global FC
* 2015 United Football League; runners up
# Lucas del Rosario

Lucas Gabriel Yap del Rosario (born April 30, 1999) is an American professional soccer player who plays as a midfielder for Philippines Football League club Kaya-Iloilo.

## Career
### North Carolina

In 2017, he appeared in his inaugural season with Tar Heels. He recorded his first goal against UNC Greensboro.

### Maharlika FC

In February 2024, Maharlika signed Del Rosario. He scored the first goal in a 2–1 loss against Manila Digger in the 2024 PFL season.

## International career

Del Rosario is a youth international for the United States. He has represented the under-15, under-16, under-17, and under-18 sides.

## Personal life

Lucas del Rosario was born in the United States and is of Filipino descent. He is the son of Joel and Maria del Rosario. He has two brothers, Joaquin, played soccer at NC State and Drexel.
# Bifeprunox

Bifeprunox (INN) (code name DU-127,090) is an atypical antipsychotic which, similarly to aripiprazole, combines minimal D$_2$ receptor agonism with serotonin receptor agonism. It was under development for the treatment of schizophrenia, psychosis and Parkinson's disease.
In a multi-center, placebo-controlled study, 20 mg of bifeprunox was found to be significantly more effective than placebo at reducing symptoms of schizophrenia, with a low incidence of side effects. An NDA for Bifeprunox was filed with the U.S. Food and Drug Administration in January 2007. The FDA rejected the application in August 2007. In June 2009, Solvay and Wyeth decided to cease development because "efficacy data did not support pursuing the existing development strategy of stabilisation of non-acute patients with schizophrenia."

## Pharmacodynamics

Bifeprunox is an atypical antipsychotic that is a partial D2 agonist.
# Muhammad Safdar Shakir

Muhammad Safdar Shakir (born 13 January 1952) is a Pakistani politician who was a member of the Provincial Assembly of the Punjab from August 2018 till January 2023.

## Early life

He was born on 13 January 1952 in Mamu Kanjan, Punjab, Pakistan. His family belongs to a very religious background. his father started the SOAP manufacturing business as the "KHAJOOR Marka SOAP" factory.

## Political career

He was elected to the Provincial Assembly of the Punjab as a candidate of Pakistan Muslim League (N) from Constituency PP-104 (Faisalabad-VIII in 2018 Pakistani general election.
# John G. Owens

John G. Owens (27 September 1865 – 18 February 1893) was an American archaeologist who specialized in Mayan culture, and who also published ethnological studies on the Pueblo Indians of the American Southwest.
He was born in Lewisburg, Pennsylvania, and graduated from Bucknell University in 1887. He received his master's degree from Harvard, and was the holder of the Hemenway Fellowship while he completed his doctorate under Professor Frederic Ward Putnam.
In 1892 Owens led the Harvard Peabody Museum's expedition to the Mayan city of Copán, Honduras, which began the excavation of the "Hieroglyphic Stairway" there. Unfortunately, prior to the completion of work, he was incapacitated by fever and died at Copán in 1893, where he is buried.

## Memorials

The John G. Owens Fellowship in Mesoamerican Archaeology was established at Harvard's Peabody Museum in his memory.

## Publications

* Owens, John G. (1891). "Some Games of the Zuni". Popular Science Monthly. 39: 39–50.
* Owens, John G. (1892). "Natal Ceremonies of the Hopi Indians". Journal American Ethnology and Archaeology. 2: 161–175.
# Landscape with a Church at Twilight

Landscape with a Church at Twilight is an oil painting study created in 1883 by Vincent van Gogh.
# Moscow Saga

Moscow Saga (Russian: Московская сага, romanized: Moscovskaya Saga) is a Russian television series loosely based on the eponymous trilogy Vasily Aksyonov. The shooting took place in the winter and spring of 2004. It aired from 11 October to 12 November 2004 on Channel One Russia.

## Plot

Moscow Saga shows the fate of family of medicine professor Boris Nikitich Gradov from the mid-1920s to mid-1950s against the background of the history of the new Soviet state. Boris' character represents the old dynasty of Russian doctors. His sons and daughter did not continue in his footsteps, but instead chose other professions. The eldest son, Nikita, joined the military; the younger, Kirill, became a Marxist theoretician; and Boris' daughter Nina became a writer.

## Cast

Source:
* Yuri Solomin as Boris Nikitich Gradov
* Inna Churikova as Mary Gradova
* Alexander Baluev as Nikita Gradov
* Ekaterina Nikitina as Veronica Gradova
* Alexey Zuev as Kirill Gradov
* Olga Budina as Nina Gradova
* Alexey Kortnev as Vadim Vuinovich
* Kristina Orbakaite as Vera Gorda (prototype — singer Nina Dorda)
* Dmitry Kharatyan as Shevchuk (guard in the Gulag)
* Marianna Schultz as Celia Rosenblum
* Victoria Tolstoganova as Tasia Pyzhykova
* Andrei Smirnov as Leonid Pulkovo
* Sergei Bezrukov as Vasily Stalin
* Marina Yakovleva as Agasha
* Alexander Rezalin as Nugzar
* Igor Bochkin as Petukhov
* Ilya Noskov as Boris Gradov IV
* Dmitry Ulyanov as Semyon Stroilo
* Elena Kasyanova as Mayka Strepetova
* Irina Kupchenko as Mayka's mother
* Marina Shvydkaya as Elizaveta
* Andrey Ilin as Savva Kitaygorodsky
* Valery Ivakov as Vaskov
* Vladimir Mironov as Joseph Stalin
* Igor Sklyar as Mikhail Frunze
* Pavel Remezov as Molotov
* Alexei Makarov as Alexander Sheremetyev
* Vitaly Egorov as Sandro Pevzner
* Anna Snatkina as Yolka Kitaygorodskaya
* Vladimir Dolinsky as Shaytis
* Irina Brazgovka as Leonid Pulkovo's beloved
* Mikhail Yefremov as party organizer of the medical institute
* Tatiana Samoilova as Professor
* Vyacheslav Shalevich as General
* Regimantas Adomaitis as journalist Reston
* Emilyano Ochagaviya as Galaktion Gudiashvili
* Nana Mchedlidze as Keke, Stalin's mother
* Alexey Bysh as Obersturmbannfuehrer
# Unni appam

Unni appam (Malayalam: ഉണ്ണിയപ്പം) is a small round snack made from rice, jaggery, banana, roasted coconut pieces, roasted sesame seeds, ghee and cardamom powder fried in oil. Variations of this organic and spongy fried batter using jackfruit preserves instead of banana is common from the late 90s. It is a popular snack in Kerala. In Malayalam, unni means small and appam means rice cake.
# Simon Casady

Simon Casady (June 16, 1852 – March 25, 1928) was a prominent banker in Iowa, best known for his role in organizing the Des Moines Bank, which later evolved into the Des Moines Savings Bank. Casady served as the president of the Des Moines Savings Bank and the Central State Bank, as well as the vice president of the Iowa National Bank and the treasurer of the Bankers Life Association. Casady has been referred to as "the dean of Iowa bankers" in news accounts.He was a member of the Casady family, an influential lineage of bankers, politicians, landowners, and farmers who played a significant role in the early history and legislative matters of Iowa.

## Life

Born in Des Moines in 1852, at 314 Fifth Street, in a house that later became the site of the Central State Bank, where he would later serve as president, Simon Casady was the son of state senator and judge Phineas M. Casady and his wife Wilhelmina Augusta Grimmel. Judge Casady was an early pioneer settler in Iowa and held prominence in both city and state politics. On June 1, 1880, Casady and his wife, Sarah Conarroe Griffiths, became the first native-born settler couple to be married in Des Moines, having their wedding at the Cathedral Church of Saint Paul. A court case between Simon Casady and his brother Frank Casady, concerning inheritance from their father Phineas, known as Casady v. Casady, 184 Iowa 1241 (1918), was taken to the Iowa Supreme Court, which ruled in favor of Simon Casady.
Casady and his family resided in Rosebrae, a home situated on Prospect Boulevard in Des Moines. In 1920, a Casady family reunion commemorated the 40th wedding anniversary of Casady and Sarah, and notable attendees included Thomas Casady.
Simon Casady held membership in the Benevolent and Protective Order of Elks. He was also a founding member and treasurer of the Des Moines Club, which is now recognized as the Des Moines Embassy Club.
Simon's wife, Sarah, actively opposed the extension of women's suffrage. In January 1916, Sarah Casady established and led the Iowa branch of the National Association Opposed to Woman Suffrage (NAOWS). This organization primarily comprised middle to upper-class, college-educated Christian housewives.
Casady was a staunch supporter of prohibition in the United States.
Casady died at the age of 76 on March 25, 1928, following a lengthy illness due to heart problems. In the several years prior to his death, Casady was one of the wealthiest residents of Des Moines. Due to his contributions to Iowa business and politics, he received tributes from state governor John Hammill, Des Moines Mayor Fred H. Hunter, and local business leaders.

## Legacy

The Simon Casady Residence, built in 1905, is still standing and is located on 715 Hickman Road in Des Moines. The original address for the Simon Casady Residence was 715 Prospect Road, Des Moines.
Casady's descendants remained active in Iowa banking and agriculture. His son Simon Casady Jr. was a co-founder of Pioneer Hi Bred International and his grandson Simon Wheeler Casady III was a Pioneer director and secretary and on the board of directors of Central National Bancshares.
# Campbell E. Beaumont

Campbell Eben Beaumont (August 27, 1883 – November 19, 1954) was a United States district judge of the United States District Court for the Southern District of California.

## Education and career

Born in Mayfield, Kentucky, Beaumont was in the Kentucky National Guard from 1904 to 1906, and received a Bachelor of Laws from the Cumberland School of Law (then part of Cumberland University, now part of Samford University) in 1910. He was in private practice from 1912 to 1914, when he became a deputy district attorney of Fresno County, California, serving from 1914 to 1917. He was an assistant district attorney of Fresno County in 1917, and was the district attorney of that county from 1918 to 1921. He was a judge of the California Superior Court from 1921 to 1939.

## Federal judicial service

On July 27, 1939, Beaumont was nominated by President Franklin D. Roosevelt to a new seat on the United States District Court for the Southern District of California created by 52 Stat. 584. He was confirmed by the United States Senate on August 1, 1939, and received his commission on August 5, 1939. Beaumont served in that capacity until his death on November 19, 1954.
# LPXTGase

LPXTGase refers to an endopeptidase enzyme from Streptococci and Staphylococci with the capacity to cleave the carboxy-terminal LPXTG anchor motif of surface proteins similar to Sortase. However, LPXTGase differs significantly from Sortase in several ways: a) it is glycosylated, b) it contains unconventional amino acids, and c) it contains D-amino acids. The latter two characteristics indicate that ribosomes are not involve in the synthesis of LPXTGase. Data suggest that the enzymes responsible for cell wall assembly also assemble LPXTGase.
This is the first enzyme of its kind ever reported and was discovered in streptococcal and staphylococcal lysates due to its high cleavage activity for the LPXTG sequence (200x more active than sortase). While there are only three publications describing this enzyme, all from the same source, they are in high quality peer reviewed journals. One reason for this limitation is that there is no single gene that codes for LPXTGase (it does not fit the "one gene one enzyme" theory) making its manipulation purely biochemical. Thus, reproducibility from other sources is a slow limiting process.
# Heiner Moraing

Heiner Moraing (born 3 August 1964) is a former professional tennis player from West Germany.

## Career

To qualify for the 1988 Wimbledon Championships, Moraing managed to defeat former quarter-finalist Vijay Amritraj in his final qualification match, which went for five sets, including two tiebreaks, before being won by West German 8–6 in the fifth. He defeated British wildcard Mark Petchey in the first round of the main draw, but lost in the second round, to fellow qualifier Barry Moir, in four sets. With his elder brother Peter as his partner, Moraing competed in the men's doubles as well. The pair were eliminated in the opening round by Sergio Casal and Emilio Sánchez.
He also took part in both the singles and doubles draws of the 1989 Australian Open. In the singles he had a win in the opening round, over Thierry Tulasne, who retired in the third set with sickness, after losing the first two sets. He was unable to progress past fourth seed Stefan Edberg in his next match, losing in straight sets. The West German didn't do as well in the doubles, with he and partner Torben Theine losing in the first round.
Outside of Grand Slams, Moraing had his best performance on tour at the 1988 German Open, where he beat the 42nd ranked player in the world Eric Jelen. The previous year he was a semi-finalist at a Challenger event in Vancouver and made the doubles final at another Challenger tournament, in Bossonnens, partnering Alexander Mronz.
Moraing is now a tennis coach and runs a tennis center with his brother in Mülheim.
# Adam Szłapka

Adam Stanisław Szłapka (born December 6, 1984, in Kościan) is a Polish politician, political scientist, and local government official. He has been a member of the Sejm (Polish Parliament) for the 8th, 9th, and 10th terms (since 2015). He has served as the leader of the Modern party (Nowoczesna) since 2019 and has been the Minister for European Union Affairs in Donald Tusk's third government since 2023.

## Early life and education

Szłapka was born on 6 December 1984 in Kościan, Greater Poland Voivodeship. He graduated from the Oskar Kolberg High School No. 1 in Kościan. He subsequently graduated in political science and Eastern studies from the Adam Mickiewicz University in Poznań.

## Political career

He was an activist of Młode Centrum, a youth organization of the Freedom Union and Democratic Party. Between 2006-2012 he worked as the general secretary of these organizations.
Between 2006-2010, he served as town councillor in Kościan representing the Self-Government Democratic Forum (Samorządowe Forum Demokratyczne). In 2010, he unsuccessfully ran for office in the local government elections. He was director of the Fundacja: Projekt Polska. In the years 2011-2015, he worked as an expert in the Chancellery of the President Bronisław Komorowski.
In 2015, he assumed the post of general secretary of the Modern (.Nowoczesna) party. The same year, he stood for election to the Sejm and won a seat from the Kalisz constituency. He was appointed a member of the Foreign Affairs Parliamentary Committee as well as the Secret Service Committee. In the 2019 Polish parliamentary election, he was re-elected as member of parliament receiving 51,951 votes in the Poznań constituency.
On 24 November 2019, he replaced Katarzyna Lubnauer as leader of the Modern political party. He has expressed his support for the legalization of same-sex marriage in Poland.
Following the 2023 election, on 13 December 2023, he assumed the post of Minister for the European Affairs in Donald Tusk's third cabinet. During a European Parliament debate on the humanitarian crisis in Gaza, Adam Szłapka, was seen laughing multiple times as Belgian MEP Marc Botenga addressed the issue. Botenga later called him out for his behavior, highlighting the insensitivity of such a reaction in the context of severe human suffering.
The incident sparked outrage, with critics condemning it as a sign of disregard for Palestinian lives. Some accused European institutions of complicity in Israel’s actions, pointing to the laughter as a symbol of broader indifference. The episode has added to ongoing debates about Europe’s role in the Israeli-Palestinian conflict and the moral responsibility of its leaders.

## Results in National Elections

| Election | Electoral Committee | Office | District | Result |
| 2015 | Modern | Sejm (8th term) | no. 36 | 12,539 (3.45%)Y |
| 2019 | Civic Coalition | Sejm (9th term) | no. 39 | 51,951 (10.10%)Y |
| 2023 | Civic Coalition | Sejm (10th term) | no. 39 | 149,064 (25.01%)Y |
# Overhand loop

The overhand loop is a simple knot which forms a fixed loop in a rope. Made by tying an overhand knot in the bight, it can be tied anywhere along a rope (does not need any working end). The knot can be used for attaching clips, hooks, other rope, etc., but has the disadvantage that it is likely to jam tight when the rope has been pulled and the knot may need to be cut off. It also has some uses in kite-flying, though other knots may be better. It is commonly disapproved by cadets because of its tendency to be misused as an alternative to the bowline. (Reference 1 also contains a sequence of images that show how to tie an overhand knot.)
# One Eyed Jacks (album)

One Eyed Jacks is the second studio album by Spear of Destiny, released by Burning Rome Records in 1984.

## Track listing

All songs written by Kirk Brandon
* "Rainmaker" - 2:55
* "Young Men" - 3:13
* "Everything You Ever Wanted" - 4:36
* "Don't Turn Away" - 3:38
* "Liberator" - 3:39
* "Prisoner of Love" - 3:36
* "Playground of the Rich" - 4:45
* "Forbidden Planet" - 3:14
* "Attica" - 2:34
* "These Days Are Gone" - 5:41

## Personnel
### Spear of Destiny

* Kirk Brandon - vocals, guitar
* Stan Stammers - bass guitar
* Dolphin Taylor - drums, vocals
* Neil Pyzer - keyboards, saxophone, piccolo flute
* Mickey Donnelly - saxophone
* Alan St. Clair - guitar

### Technical

* Gary Langan - mixing
* Pete Wilson - mixing on "Prisoner of Love"
* David Levine, Steve Rapport - photography

## Recording

With the exception of "These Days Are Gone", "Playground of the Rich" and "Prisoner of Love", all songs had been performed live by the original Spear of Destiny line-up for nearly a year prior to the recording of One Eyed Jacks. "Everything You Ever Wanted", "Attica", "Rainmaker", "Young Men", "Forbidden Planet" and "Don't Turn Away" were introduced to live sets in March 1983, with "Young Men" going by the title of "Remembrance (Every Other Day)". "Liberator" was introduced to live shows in the early summer of 1983. The final live performance of the original line-up of Spear of Destiny took place on 9 June 1983, followed by a television studio performance on 8 July.
August saw Spear of Destiny return to the stage, this time with the introduction of Dolphin Taylor on drums, Neil Pyzer on saxophone, piano, and organ, and John Lennard on saxophone. The new line-up featured a dramatic reworking of the songs that were to eventually become One Eyed Jacks, along with the introduction of "Playground of the Rich" and "Rosie", a song that would later be featured as the b-side to the line up's first recorded output, the single "Prisoner of Love". A tour in November premiered "The Last Card". Although it proceeded the release of One Eyed Jacks by six months, "The Last Card" would not be featured on a studio recording until the release of the "All My Love (Ask Nothing)" single in 1985.
"Prisoner of Love" was added to the live set in December 1983 and would be released as the first single for the record in January 1984. By this time, John Lennard had left the band, replaced by Mickey Donnelly. The band also added Alan St. Clair as a second guitarist. St. Clair had previously worked for Kirk Brandon as a guitar technician.