# List of psychoactive plants

This is a list of plant species that, when consumed by humans, are known or suspected to produce psychoactive effects: changes in nervous system function that alter perception, mood, consciousness, cognition or behavior. Many of these plants are used intentionally as psychoactive drugs, for medicinal, religious, and/or recreational purposes. Some have been used ritually as entheogens for millennia.
The plants are listed according to the specific psychoactive chemical substances they contain; many contain multiple known psychoactive compounds.

## Cannabinoids

Species of the genus Cannabis, known colloquially as marijuana, including Cannabis sativa and Cannabis indica, is a popular psychoactive plant that is often used medically and recreationally. The principal psychoactive substance in Cannabis, tetrahydrocannabinol (THC), contains no nitrogen, unlike many (but not all) other psychoactive substances and is not an indole, tryptamine, phenethylamine, anticholinergic (deliriant) or dissociative drug. THC is just one of more than 100 identified cannabinoid compounds in Cannabis, which also include cannabinol (CBN) and cannabidiol (CBD).
Cannabis plants vary widely, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) and yielding markedly different effects. Popular strains are often hybrids of C. sativa and C. indica.
The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research firms. Many jurisdictions have laws regulating or prohibiting the cultivation, sale and/or use of medical and recreational cannabis.

## Tryptamines

Many of the psychedelic plants contain dimethyltryptamine (DMT), or other tryptamines, which are either snorted (Virola, Yopo snuffs), vaporized, or drunk with MAOIs (Ayahuasca). It cannot simply be eaten as it is not orally active without an MAOI and it needs to be extremely concentrated to be vaporized.

### Acanthaceae

"Species, Alkaloid content, where given, refers to dried material"
* Fittonia albivenis, a common ornamental plant from South America.

### Aceraceae

* Acer saccharinum (silver maple) was found to contain the indole alkaloid gramine (not active and extremely toxic) 0.05% in the leaves, so it is possible that other members of this plant family contain active compounds.

### Aizoaceae

* Delosperma acuminatum, DMT, 5-MeO-DMT
* Delosperma cooperi, DMT, 5-MeO-DMT
* Delosperma ecklonis, DMT
* Delosperma esterhuyseniae, DMT
* Delosperma hallii, 5-MeO-DMT
* Delosperma harazianum, DMT, 5-MeO-DMT
    Delosperma harazianum Shibam, DMT
* Delosperma hirtum, DMT
    Delosperma hallii aff. litorale
* Delosperma lydenbergense, DMT, 5-MeO-DMT
* Delosperma nubigenum, 5-MeO-DMT
* Delosperma pageanum, DMT, 5-MeO-DMT
* Delosperma pergamentaceum, Traces of DMT
* Delosperma tradescantioides, DMT

### Apocynaceae

* Prestonia amazonica: DMT
* Voacanga africana: Up to 10% Iboga alkaloids

### Asteraceae

* Pilosella officinarum

### Erythroxylaceae

* Erythroxylum pungens: DMT

### Fabaceae (Leguminosae)

* Acacia acuminata, Up to 1.5% alkaloids, mainly consisting of dimethyltryptamine in bark & leaf Also, harman, tryptamine, NMT, other alkaloids in leaf.
* Acacia alpina, Active principles in leaf
* Acaciella angustissima, β-methyl-phenethylamine, NMT and DMT in leaf (1.1-10.2 ppm)
* Vachellia aroma, Tryptamine alkaloids. Significant amount of tryptamine in the seeds.
* Acacia auriculiformis, 5-MeO-DMT in stem bark
* Acacia baileyana, 0.02% tryptamine and β-carbolines, in the leaf, Tetrahydroharman
* Acacia beauverdiana, Psychoactive Ash used in Pituri.
* Senegalia berlandieri, DMT, phenethylamine, mescaline, nicotine
* Senegalia catechu, DMT and other tryptamines in leaf, bark
* Vachellia caven, Psychoactive
* Senegalia chundra, DMT and other tryptamines in leaf, bark
* Acacia colei, DMT
* Acacia complanata, 0.3% alkaloids in leaf and stem, almost all N-methyl-tetrahydroharman, with traces of tetrahydroharman, some of tryptamine
* Acacia confusa, DMT & NMT in leaf, stem & bark 0.04% NMT and 0.02% DMT in stem. Also N,N-dimethyltryptamine N-oxide
* Vachellia cornigera, Psychoactive, Tryptamines DMT according to C. Rastch.
* Acacia cultriformis, Tryptamine, in the leaf, stem and seeds. Phenethylamine in leaf and seeds
* Acacia cuthbertsonii, Psychoactive
* Acacia decurrens, Psychoactive, but less than 0.02% alkaloids
* Acacia delibrata, Psychoactive
* Acacia falcata, Psychoactive, but less than 0.02% alkaloids
* Vachellia farnesiana, Traces of 5-MeO-DMT in fruit. β-methyl-phenethylamine, flower. Ether extracts about 2–6% of the dried leaf mass. Alkaloids are present in the bark and leaves.
* Acacia flavescens, Strongly Psychoactive, Bark
* Acacia floribunda, Tryptamine, phenethylamine, in flowers other tryptamines, DMT,tryptamine,NMT 0.3–0.4% phyllodes.
* Acacia georginae, Psychoactive, plus deadly toxins
* Vachellia horrida, Psychoactive
* Acacia implexa, Psychoactive
* Mimosa jurema, DMT, NMT
* Vachellia karroo, Psychoactive
* Senegalia laeta, DMT, in the leaf
* Acacia longifolia, 0.2% tryptamine in bark, leaves, some in flowers, phenylethylamine in flowers, 0.2% DMT in plant. Histamine alkaloids.
* Acacia sophorae, Tryptamine in leaves, bark
* Acacia macradenia, Tryptamine
* Acacia maidenii, 0.6% NMT and DMT in about a 2:3 ratio in the stem bark, both present in leaves
* Acacia mangium, Psychoactive
* Acacia melanoxylon, DMT, in the bark and leaf, but less than 0.02% total alkaloids
* Senegalia mellifera, DMT, in the leaf
* Vachellia nilotica, DMT, in the leaf
* Vachellian ilotica subsp. adstringens, Psychoactive, DMT in the leaf
* Acacia neurophylla DMT in bark, Harman in leaf.
* Acacia obtusifolia, Tryptamine, DMT, NMT, other tryptamines, 0.4–0.5% in dried bark,0.15–0.2% in leaf, 0.07% in branch tips.
* Vachellia oerfota, Less than 0.1% DMT in leaf, NMT
* Acacia penninervis, Psychoactive
* Acacia phlebophylla, 0.3% DMT in leaf, NMT
* Acacia podalyriifolia, Tryptamine in the leaf, 0.5% to 2% DMT in fresh bark, phenethylamine, trace amounts. Although this species is claimed to contain 0.5% to 2% DMT in fresh bark the reference for this is invalid as there is no reference to Acacia Podalyriffolia anywhere in the reference article. Additionally, well known and proven extraction techniques for DMT have failed to produce any DMT or alkaloids from fresh bark or the leaves on multiple sample taken at various seasons. Should DMT actually exist in this species of Acacia then it exists in extremely small amounts and have failed to produce any alkaloids with Acid/Base extraction techniques using HCl/Na(OH)2. On the same note, more academic research is definitely required into the DMT content of this and other Australian Acacia species with proper chemical analysis of sample.
* Senegalia polyacantha, DMT in leaf and other tryptamines in leaf, bark
* Senegalia polyacantha ssp. campylacantha, Less than 0.2% DMT in leaf, NMT; DMT and other tryptamines in leaf, bark
* Senegalia rigidula: Phenethylamine, tryptamine, tyramine, and β-Methylphenethylamine.
* Acacia sassa, Psychoactive
* Vachellia schaffneri, β-methyl-phenethylamine, Phenethylamine
* Senegalia senegal, Less than 0.1% DMT in leaf, NMT, other tryptamines. DMT in plant, DMT in bark.
* Vachellia seyal, DMT, in the leaf. Ether extracts about 1–7% of the dried leaf mass.
* Vachellia sieberiana, DMT, in the leaf
* Acacia simplex, DMT and NMT, in the leaf, stem and trunk bark, 0.81% DMT in bark, MMT
* Vachellia tortilis, DMT, NMT, and other tryptamines
* Acacia vestita, Tryptamine, in the leaf and stem, but less than 0.02% total alkaloids
* Acacia victoriae, tryptamines, 5-MeO-alkyltryptamine
* List of acacia species having little or no alkaloids in the material sampled: (0% $\leq$ C $\leq$ 0.02%, Concentration of alkaloids)
** Acacia acinacea
** Acacia baileyana
** Acacia decurrens
** Acacia dealbata
** Acacia mearnsii
** Acacia drummondii
** Acacia elata
** Acacia falcata
** Acacia leprosa
** Acacia linearis
** Acacia melanoxylon
** Acacia pycnantha
** Acacia retinodes
** Acacia saligna
** Acacia stricta
** Acacia verticillata
** Acacia vestita
* Pseudalbizzia inundata leaves contain DMT.
* Anadenanthera colubrina, Bufotenin, Beans, Bufotenin oxide, Beans, N,N-Dimethyltryptamine, Beans, pods,
* Anadenanthera colubrina var. cebil – Bufotenin and Dimethyltryptamine have been isolated from the seeds and seed pods, 5-MeO-DMT from the bark of the stems. The seeds were found to contain 12.4% bufotenine, 0.06% 5-MeO-DMT and 0.06% DMT.
* Anadenanthera peregrina,
1,2,3,4-Tetrahydro-6-methoxy-2,9-dimethyl-beta-carboline, Plant, 1,2,3,4-Tetrahydro-6-methoxy-2-methyl-beta-carboline, Plant, 5-Methoxy-N,N-dimethyltryptamine, Bark, 5-Methoxy-N-methyltryptamine, Bark, Bufotenin, plant, beans, Bufotenin N-oxide, Fruit, beans, N,N-Dimethyltryptamine-oxide, Fruit
* Anadenanthera peregrina var. peregrina, Bufotenine is in the seeds.
* Desmanthus illinoensis, 0–0.34% DMT in root bark, highly variable. Also NMT, N-hydroxy-N-methyltryptamine, 2-hydroxy-N-methyltryptamine, and gramine (toxic).
* Desmanthus leptolobus, 0.14% DMT in root bark, more reliable than D. illinoensis
* Desmodium caudatum (syn. Ohwia caudata), Roots: 0.087% DMT,
* Codariocalyx motorius(syn. Desmodium gyrans), DMT, 5-MeO-DMT, leaves, roots
* Desmodium racemosum, 5-MeO-DMT
* Desmodium triflorum, 0.0004% DMT-N-oxide, roots, less in stems and trace in leaves.
* Lespedeza capitata
* Lespedeza bicolor, DMT, Lespedamine, and 5-MeO-DMT in leaves and roots
* Lespedeza bicolor var. japonica, DMT, 5-MeO-DMT in leaves and root bark
* Mimosa ophthalmocentra, Dried root: DMT 1.6%, NMT 0.0012% and hordenine 0.0065%
* Mimosa scabrella, tryptamine, NMT, DMT and N-methyltetrahydrocarboline in bark
* Mimosa somnians, tryptamines and MMT
* Mimosa tenuiflora (syn. "Mimosa hostilis"), 0.31-0.57% DMT (dry root bark).
* Mimosa verrucosa, DMT in root bark
* Mucuna pruriens, the seeds of the plant contain about 3.1–6.1% L-DOPA.
* Petalostylis casseoides, 0.4–0.5% tryptamine, DMT, etc. in leaves and stems
* Petalostylis labicheoides var. casseoides, DMT in leaves and stems; 0.4–0.5% alkaloids in leaves and stems; Tryptamines in leaves and stems, MAO's up to 0.5%
* Phyllodium pulchellum(syn. Desmodium pulchellum), DMT; 0.2% 5-MeO-DMT, small quantities of DMT DMT (dominates in seedlings and young plants), 5-MeO-DMT (dominates in mature plant), whole plant, roots, stems, leaves, flowers;
* Erythrina flabelliformis, other Erythrina species, seeds contain the alkaloids erysodin and erysovin
* Zornia latifolia, the flavones genistein, apigenin and syzalterin may explain the cannabis-like effects

### Lauraceae

* Nectandra megapotamica, NMT

### Malpighiaceae

* Diplopterys cabrerana: McKenna et al. (1984) assayed and found the leaves contain 0.17% DMT

### Myristicaceae

* Horsfieldia superba: 5-MeO-DMT, Horsfiline, and beta-carbolines
* Iryanthera macrophylla: 5-MeO-DMT in bark;
* Iryanthera ulei: 5-MeO-DMT in bark
* Osteophloem platyspermum: DMT, 5-MeO-DMT in bark
* Virola calophylla, Leaves 0.149% DMT, leaves 0.006% MMT 5-MeO-DMT in bark
* Virola calophylloidea, DMT, 5-MeO-DMT
* Virola carinata, DMT in leaves; DMT, 5-MeO-DMT
* Virola cuspidata, DMT
* Virola divergens, DMT in leaves
* Virola elongata(syn. Virola theiodora), DMT, 5-MeO-DMT in bark, roots, leaves and flowers
* Virola melinonii, DMT in bark; DMT, 5-MeO-DMT
* Virola multinervia, DMT, 5-MeO-DMT in bark and roots
* Virola pavonis, DMT in leaves
* Virola peruviana, DMT, 5-MeO-DMT; 5-MeO-DMT, traces of DMT and 5-MeO-tryptamine in bark
* Virola rufula, Alkaloids in bark and root, 95% of which is MeO-DMT 0.190% 5-MeO-DMT in bark, 0.135% 5-MeO-DMT in root, 0.092% DMT in leaves.
* Virola sebifera, The bark contains 0.065% to 0.25% alkaloids, most of which are DMT and 5-MeO-DMT.
* Virola venosa, DMT, 5-MeO-DMT in roots, leaves DMT

### Ochnaceae

* Testulea gabonensis: 0.2% 5-MeO-DMT, small quantities of DMT, DMT in bark and root bark, NMT

### Pandanaceae

* Genus Pandanus (Screw Pine): DMT in nuts

### Poaceae (Gramineae)

Some Graminae (grass) species contain gramine, which can cause brain damage, other organ damage, central nervous system damage and death in sheep.
* Arundo donax, 0.0057% DMT in dried rhizome, no stem, 0.026% bufotenine, 0.0023% 5-MeO-MMT
* Phalaris aquatica, 0.0007–0.18% Total alkaloids, 0.100% DMT, 0.022% 5-MeO-DMT, 0.005% 5-OH-DMT
* Phalaris arundinacea, 0.0004–0.121% Total alkaloids
* Phalaris brachystachys, aerial parts up to 3% total alkaloids, DMT present
* Phalaris coerulescens, Coerulescine and 2-methyl-1,2,3,4-Tetrahydro-β-carboline in rhizome.
* Phragmites australis, DMT, 5-MeO-DMT, bufotenine and gramine in the rhizome.
None of the above alkaloids are said to have been found in Phalaris californica, Phalaris canariensis, Phalaris minor and hybrids of P. arundinacea together with P. aquatica.

### Polygonaceae

* Eriogonum : DMT

### Rubiaceae

* Psychotria carthagenensis, 0.2% average DMT in dried leaves.
* Psychotria colorata, Presence of mu opioid receptor(MOR) agonist and NMDA antagonist: hodgkinsine, psychotridine. Also mentioned in The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.
* Psychotria expansa, DMT
* Psychotria forsteriana, DMT
* Psychotria insularum, DMT
* Psychotria poeppigiana, DMT
* Psychotria rostrata, DMT
* Psychotria rufipilis, DMT
* Psychotria viridis, DMT 0.1–0.61% dried mass.

### Rutaceae

* Dictyoloma incanescens, 5-MeO-DMT in leaves, 0.04% 5-MeO-DMT in bark
* Dutaillyea drupacea, > 0.4% 5-MeO-DMT in leaves
* Dutaillyea oreophila, 5-MeO-DMT in leaves
* Tetradium ruticarpum(syn. Evodia rutaecarpa), 5-MeO-DMT in leaves, fruit and roots
* Limonia acidissima, Traces of DMT; 5-MeO-DMT in stems
* Euodia leptococca (formerly Melicope), 0.2% total alkaloids, 0.07% 5-MeO-DMT; 5-MeO-DMT in leaves and stems, also "5-MeO-DMT-Oxide and a beta-carboline"
* Pilocarpus organensis, DMT, 5-MeO-DMT in leaves (Might also contain pilocarpine)
* Vepris ampody, Up to 0.2% DMT in leaves and branches
* Zanthoxylum arborescens, Traces of DMT; DMT in leaves
* Zanthoxylum procerum, DMT in leaves
* Citrus limon, DMT, N-Methylated tryptamine derivative in leaves
* Citrus sinesis,DMT, N-Methylated tryptamine derivative
* Citrus bergamia,DMT, N-Methylated tryptamine derivative
* Mandarin orange Traces of N-methylated tryptamine derivative in leaf.
* Chinotto Tree, N-Methylated tryptamine derivative in leaf
* Citrus medica, N-Methylated tryptamine derivative in leaf

## Phenethylamines

Species, Alkaloid Content (Fresh) – Alkaloid Content (Dried)
* Coryphantha contains various phenethylamine alkaloids including macromerine, coryphanthine, O-methyl-candicine, corypalmine, and N-methyl-corypalmine.
* Cylindropuntia echinocarpa (syn. Opuntia echinocarpa), Mescaline 0.01%, DMPEA 0.01%, 4-hydroxy-3-5-dimethoxyphenethylamine 0.01%
* Cylindropuntia spinosior (syn. Opuntia spinosior), Mescaline 0.00004%, 3-methoxytyramine 0.001%, tyramine 0.002%, 3-4-dimethoxyphenethylamine.
* Echinopsis lageniformis (syns Echinopsis scopulicola, Trichocereus bridgesii), Mescaline > 0.025%, also DMPEA < 1%, 3-methoxytyramine < 1%, tyramine < 1%; Mescaline 2%
* Echinopsis macrogona (syn. Trichocereus macrogonus), > 0.01–0.05% Mescaline
* Echinopsis pachanoi (syn. Trichocereus pachanoi), Mescaline 0.006–0.12%, 0.05% Average; Mescaline 0.01%–2.375%
* Echinopsis peruviana (syn. Trichocereus peruvianus), Mescaline 0.0005%–0.12%; Mescaline
* Echinopsis spachiana (syn. Trichocereus spachianus), Mescaline; Mescaline
* Echinopsis tacaquirensis subsp. taquimbalensis (syn. Trichocereus taquimbalensis), > 0.005–0.025% mescaline
* Echinopsis terscheckii (syn. Trichocereus terscheckii, Trichocereus werdemannianus) > 0.005–0.025% Mescaline; mescaline 0.01%–2.375%
* Echinopsis valida, 0.025% mescaline
* Lophophora williamsii (Peyote), 0.4% Mescaline; 3–6% Mescaline
* Opuntia acanthocarpa Mescaline
* Opuntia basilaris Mescaline 0.01%, plus 4-hydroxy-3-5-dimethoxyphenethylamine
* Pelecyphora aselliformis, mescaline

## Beta-carbolines

Beta-carbolines are "reversible" MAO-A inhibitors. They are found in some plants used to make Ayahuasca. In high doses the harmala alkaloids are somewhat hallucinogenic on their own. β-carboline is a benzodiazepine receptor inverse agonist and can therefore have convulsive, anxiogenic and memory enhancing effects.

### Apocynaceae

* Amsonia tabernaemontana, Harman
* Aspidosperma exalatum, Beta-carbolines
* Aspidosperma polyneuron, Beta-carbolines
* Apocynum cannabinum, Harmalol
* Ochrosia nakaiana, Harman
* Pleiocarpa mutica, Beta-carbolines

### Bignoniaceae

* Newbouldia laevis, Harman

### Calycanthaceae

* Calycanthus occidentalis, Harman; Harmine

### Chenopodiaceae

* Hammada leptoclada, Harman; Tetrahydroharman, etc.
* Kochia scoparia, Harman; Harmine, etc.

### Combretaceae

* Guiera senegalensis, Tetrahydroharmine; Harman, etc.

### Cyperaceae

* Carex brevicollis, Harmine, etc.
* Carex parva, Beta-carbolines

### Elaeagnaceae

* Elaeagnus angustifolia, Harman, etc.
* Elaeagnus commutata, Beta-carbolines
* Elaeagnus hortensis, Tetrahydroharman, etc.
* Elaeagnus orientalis, Tetrahydroharman
* Elaeagnus spinosa, Tetrahydroharman
* Hippophae rhamnoides, Harman, etc.
* Shepherdia argentea, Tetrahydroharmol
* Shepherdia canadensis, Tetrahydroharmol

### Gramineae

* Arundo donax, Tetrahydroharman, etc.
* Festuca arundinacea, Harman, etc.
* Lolium perenne, (Perennial Ryegrass), Harman, etc.
* Phalaris aquatica, Beta-carbolines
* Phalaris arundinacea, Beta-carbolines

### Lauraceae

* Nectandra megapotamica, Beta-carbolines

### Leguminosae

* Acacia baileyana, Tetrahydroharman
* Acacia complanata, Tetrahydroharman, etc.
* Burkea africana, Harman, etc.
* Desmodium gangeticum, Beta-carbolines
* Desmodium gyrans, Beta-carbolines
* Mucuna pruriens, 6-Methoxyharman, Dihydroharman, Harman
* Petalostylis labicheoides, Tetrahydroharman; MAO's up to 0.5%
* Prosopis nigra, Harmalicin, Harman, etc.
* Shepherdia pulchellum, Beta-carbolines

### Loganiaceae

* Strychnos melinoniana, Beta-carbolines
* Strychnos usambarensis, Harman

### Malpighiaceae

* Banisteriopsis argentia, 5-methoxytetrahydroharman, (−)-N(6)-methoxytetrahydroharman, dimethyltryptamine-N(6)-oxide
* Banisteriopsis caapi, Harmine 0.31–0.84%, tetrahydroharmine, telepathine, dihydroshihunine, 5-MeO-DMT in bark
* Banisteriopsis inebrians, Beta-carbolines
* Banisteriopsis lutea, Harmine, telepathine
* Banisteriopsis metallicolor, Harmine, telepathine
* Banisteriopsis muricata Harmine up to 6%, harmaline up to 4%, plus DMT
* Diplopterys cabrerana, Beta-carbolines
* Cabi pratensis, Beta-carbolines
* Callaeum antifebrile(syn. Cabi paraensis), Harmine
* Tetrapterys methystica(syn. Tetrapteris methystica), Harmine

### Myristicaceae

* Gymnacranthera paniculata, Beta-carbolines
* Horsfieldia superba Beta-carbolines
* Virola cuspidata, 6-Methoxy-Harman
* Virola rufula, Beta-carbolines
* Virola theiodora, Beta-carbolines

### Ochnaceae

* Testulea gabonensis, Beta-carbolines

### Palmae

* Plectocomiopsis geminiflora, Beta-carbolines

### Papaveraceae

* Meconopsis horridula, Beta-carbolines
* Meconopsis napaulensis, Beta-carbolines
* Meconopsis paniculata, Beta-carbolines
* Meconopsis robusta, Beta-carbolines
* Meconopsis rudis, Beta-carbolines
* Papaver rhoeas, Beta-carbolines
* Papaver Bracteatum ~ Tefamine
* Papaver Paeoniflorum ~ Morphine
* Papaver Setigerum ~ Morphine
* Papaver somniferum ~ Morphine

### Passifloraceae

* Passiflora actinia, Harman
* Passiflora alata, Harman
* Passiflora alba, Harman
* Passiflora bryonoides, Harman
* Passiflora caerulea, Harman
* Passiflora capsularis, Harman
* Passiflora decaisneana, Harman
* Passiflora edulis, Harman, 0–7001 ppm in fruit
* Passiflora eichleriana, Harman
* Passiflora foetida, Harman
* Passiflora incarnata (with bee), Harmine, Harmaline, Harman, etc. 0.03%. Alkaloids in rind of fruit 0.25%
* Passiflora quadrangularis, Harman
* Passiflora ruberosa, Harman
* Passiflora subpeltata, Harman
* Passiflora warmingii, Harman

### Polygonaceae

* Calligonum minimum, Beta-carbolines
* Leptactinia densiflora, Tetrahydroharmine, etc.
* Ophiorrhiza japonica, Harman
* Pauridiantha callicarpoides, Harman
* Pauridiantha dewevrei, Harman
* Pauridiantha lyalli, Harman
* Pauridiantha viridiflora, Harman
* Simira klugei, Harman
* Simira rubra, Harman

### Rubiaceae

* Borreria verticillata, Beta-carbolines
* Leptactinia densiflora, Beta-carbolines
* Nauclea diderrichii, Beta-carbolines
* Ophiorrhiza japonica, Beta-carbolines
* Pauridiantha callicarpoides, Beta-carbolines
* Pauridiantha dewevrei, Beta-carbolines
* Pauridiantha yalli, Beta-carbolines
* Pauridiantha viridiflora, Beta-carbolines
* Pavetta lanceolata, Beta-carbolines
* Psychotria carthagenensis, Beta-carbolines
* Psychotria viridis, Beta-carbolines
* Simira klugei, Beta-carbolines
* Simira rubra, Beta-carbolines
* Uncaria attenuata, Beta-carbolines
* Uncaria canescens, Beta-carbolines
* Uncaria orientalis, Beta-carbolines
* Nauclea latifolia, Tramadol

### Rutaceae

* Tetradium (syn. Evodia) species: Some contain carbolines
* Euodia leptococca Beta-carboline
* Araliopsis tabouensis, Beta-carbolines
* Flindersia laevicarpa, Beta-carbolines
* Xanthoxylum rhetsa, Beta-carbolines

### Sapotaceae

* Chrysophyllum lacourtianum, Norharman etc.
* Scutellaria nana

### Simaroubaceae

* Ailanthus malabarica, Beta-carbolines. (See also Nag Champa)
* Perriera madagascariensis, Beta-carbolines
* Picrasma ailanthoides, Beta-carbolines
* Picrasma crenata, Beta-carbolines
* Picrasma excelsa, Beta-carbolines
* Picrasma javanica, Beta-carbolines

### Solanaceae

* Vestia foetida, (Syn V. lycioides) Beta-carbolines

### Symplocaceae

* Symplocos racemosa, Harman

### Tiliaceae

* Grewia mollis, Beta-carbolines

### Zygophyllaceae

* Fagonia cretica, Harman
* Nitraria schoberi, Beta-carbolines
* Peganum harmala, (Syrian Rue), The seeds contain about 2–6% alkaloids, most of which is harmaline. Peganum harmala is also an abortifacient.
* Peganum nigellastrum, Harmine
* Tribulus terrestris, Harmine etc.; Harman
* Zygophyllum fabago, Harmine etc.; Harman

## Opiates

Opiates are the natural products of many plants, the most famous and historically relevant of which is Papaver somniferum. Opiates are defined as natural products (or their esters and salts that revert to the natural product in the human body), whereas opioids are defined as semi-synthetic or fully synthetic compounds that trigger the Opioid receptor of the mu sub-type. Other opiate receptors, such as kappa- and delta-opiate receptors are part of this system but do not cause the characteristic behavioral depression and analgesia which is mostly mediated through the mu-opiate receptor.
An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term opioid is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). Opiates are alkaloid compounds naturally found in the Papaver somniferum plant (opium poppy). The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America.
In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65). According to the CDC, from this population, there were 47,000 deaths, with a total of 500,000 deaths from 2000 to 2014. In 2016, the World Health Organization reported that 27 million people suffer from Opioid use disorder. They also reported that in 2015, 450,000 people died as a result of drug use, with between a third and a half of that number being attributed to opioids.

### Papaver somniferum

The plant contains a latex that thickens into opium when it is dried. Opium contains approximately 40 alkaloids, which are summarized as opium alkaloids. The main psychoactive alkaloids are:
* Morphine: 3 to 20% in opium
* Codeine 0.1 to 4% in opium
* Thebaine 0.1 to 4% in opium
* Noscapine 1 to 11% in opium
* Oripavine

### Atherospermataceae

Laurelia novae-zelandiae ~ pukateine
* Cnidium officinale

### Mitragyna speciosa/Mitragyna parvifolia

* Mitragynine: Approx. 0.33% in dried leaves
* 7-Hydroxymitragynine
* Mitragynine pseudoindoxyl

### Picralima nitida

* Akuammicine
* Pericine It may also have convulsant effects.

### Psychotria colorata

* Hodgkinsine

### Aspidosperma spp.

* Akuammicine

## Plants containing other psychoactive substances

Plants containing other psychoactive substances :
| Substance(s) | Plant | Comments |
| Asarone | Acorus calamus | Toxic. |
| Yohimbine | Alchornea floribunda | α$_2$-adrenergic receptor antagonist. |
| Arecoline, Arecaidine | Areca catechu | GABA uptake inhibitor, stimulant. |
| Protopine | Argemone mexicana | Used by Chinese residents of Mexico during the early 20th century as a legal substitute for opium and currently smoked as a marijuana substitute. |
| Ergine | Argyreia nervosa (Hawaiian Baby Woodrose) | Seeds contain ergine (also known as LSA), often 50-150X the amounts found in Ipomoea violacea. LSA is a hallucinogen. |
| Thujone | Artemisia absinthium | Also called "wormwood". GABA receptor antagonist. |
| Quinoline & Aporphine alkaloids | Asimina triloba (Paw Paw) | Identical alkaloid to morphine. |
| Tropane alkaloids (scopolamine, atropine, hyoscyamine) | Atropa belladonna | Commonly known as 'deadly nightshade'. An anticholinergic deliriant. |
| Tropane alkaloids (scopolamine, atropine, and hyoscyamine) | Brugmansia | Commonly known as 'angel's trumpets'. An anticholinergic deliriant. |
| Indole alkaloids (harmine, manacine, brunfelsamidine), Tropane alkaloids (scopolamine) | Brunfelsia | Known to cause delirium, sustained mental confusion, and possible blindness. |
| Unknown | Calea zacatechichi | Produces vivid dreams after smoking. It is also employed by the Chontal people as a medicinal herb against gastrointestinal disorders, and is used as an appetizer, cathartic anti-dysentery remedy, and as a fever-reducing agent. Its psychedelic properties do not become apparent until the user is asleep. Reports describe rituals that involve drinking it as a tea to induce divinatory or lucid dreams due to its properties as an oneirogen. |
| Caffeine | Camellia sinensis | Tea leaves, tea, native to Asia. |
| Cathinone | Catha edulis | Khat, commonly chewed, produces a stimulant effect. |
| Vincristine | Catharanthus roseus | Catharanthus roseus is (perhaps unpleasantly) "hallucinogenic." |
| Unknown | Cestrum nocturnum | Commonly referred to as 'night-blooming jasmine', 'lady of the night', and 'poisonberry'. It has an unknown mechanism of action. |
| Caffeine | Coffea arabica | Coffee beans, coffee, native to Africa. |
| Caffeine | Cola | Cola or kola nut, traditional additive to cola, native to Africa. |
| (Unknown) | Coleus | Unknown |
| Bulbocapnine | Corydalis solida, cava | Bulbocapnine, Nantenine, Tetrahydropalmatine |
| Tropane alkaloids (Scopolamine, Atropine) | Datura | Also known as 'thorn apple', 'devil's trumpets', 'loco weed', and 'Jimson weed'. Scopolamine and Atropine are both anticholinergics which produce hallucinogenic and deliriant effects. It has an extensive history of being used recreationally. |
| Cytisine | Dermatophyllum | Nicotine-like effects. partial agonist of nicotinic acetylcholine receptors (nAChRs). |
| Unknown | Desfontainia spinosa | Causes visions. |
| Nicotine | Duboisia hopwoodii | Pituri |
| Unknown | Entada rheedii | African dream herb. |
| Ephedrine | Ephedra sinica | Ephedra |
| Cocaine | Erythroxylum coca | Coca. Widely used illegal stimulant, produces hallucination in overdose, native to South America. |
| Unknown | Fittonia albivenis | Nerve or mosaic plant, said to produce vision of eyeballs |
| Himbacine | Galbulimima belgraveana | Galbulimima belgraveana is rich in alkaloids and twenty-eight alkaloids have been isolated including himbacine. |
| Glaucine | Glaucium flavum | Hallucinogenic effects. |
| Possibly Cryogenine | Heimia myrtifolia | Auditory |
| Possibly Cryogenine | Heimia salicifolia | Auditory |
| Lobeline, Nicotine | Hippobroma longiflora | Star of Bethlehem |
| Hyperforin | Hypericum perforatum | Saint John's wort |
| Tropane alkaloids | Hyoscyamus | Henbane |
| Caffeine, Theobromine, Dimethylxanthines | Ilex guayusa | Ilex guayusa is used as an additive to some versions of Ayahuasca. According to the Ecuadorian indigenous, it is also slightly hallucinogenic on its own, when drunk in high enough quantities. |
| Ergine | Ipomoea tricolor & Ipomoea violacea | Ergine in seeds; up to 0.12% total Produces psychedelic effects. |
| Unknown | Justicia pectoralis | Unknown |
| Lactucarium | Lactuca virosa | Lactucarium |
| Lagochilin | Lagochilus inebrians | Lagochilin is thought to be responsible for the sedative, hypotensive and hemostatic effects of this plant. |
| Pukateine | Laurelia novae-zelandiae | Pukateine |
| Unknown | Rollinia mucosa | Rollinia mucosa is said to be a narcotic. |
| Leonurine | Leonotis leonurus | Both leaves and flowers (where most concentrated) contain Leonurine. (Effects reminiscent of marijuana) |
| Nicotine | Leucas aspera | Nicotine |
| Leonurine | Leonotis nepetifolia | Both leaves and flowers (where most concentrated) contain Leonurine and several compounds. (Effects reminiscent of marijuana) |
| Lobeline | Lobelia inflata | Indian tobacco |
| Unknown | Magnolia virginiana | |
| Tropane alkaloids (scopolamine, atropine, and hyoscyamine) | Mandragora officinarum | Mandrake has deliriant and anticholinergic properties. |
| Ergine | Some Mirabilis spp. | Possibly contains ergine, a hallucinogen. |
| Mitragynine, Mitragynine pseudoindoxyl | Mitragyna speciosa | Usually referred to as kratom. Has opioid-like and stimulant properties. |
| Myristicin | Myristica fragrans | Nutmeg |
| Aporphine | Nelumbo nucifera | Sacred lotus |
| Nepetalactone | Nepeta cataria | Catnip |
| Nicotine | Nicotiana tabacum | Tobacco. Can cause hallucinations in very large doses. |
| Aporphine, Apomorphine | Nymphaea caerulea | Blue lotus or lily. Recent studies have shown Nymphaea caerulea to have psychedelic properties, and may have been used as a sacrament in ancient Egypt and certain ancient South American cultures. Dosages of 5 to 10 grams of the flowers induces slight stimulation, a shift in thought processes, enhanced visual perception, and mild closed-eye visuals. Nymphaea caerulea is unrelated to Nelumbo nucifera the Sacred Lotus, with Nymphaea in the Nymphales, one of the oldest and most basal linegages of flowering plants and with Nelumbo in Proteales one of the core eudicots. Their morphological similarties being entirely convergent evolution, however they apparently have convergently evolved similar biochemistry. Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and apomorphine, which have been recently isolated by independent labs. These psychoactive effects make Nymphaea caerulea a likely candidate (among several) for the lotus plant eaten by the mythical Lotophagi in Homer's Odyssey. Used in aromatherapy, Nymphaea caerulea is purported to have a "divine" essence, bringing euphoria, heightened awareness and tranquility. Other sources cite anti-spasmodic and sedative, purifying and calming properties. |
| Ginsenosides | Panax | Ginseng |
| Morphine | Papaver somniferum | Opium. Widely used analgesic, native to the Old World. |
| Unknown | Phytolacca americana | Narcotic and toxic when the root is consumed. |
| Yohimbine | Pausinystalia johimbe | α$_2$-adrenergic receptor antagonist. |
| Unknown | Pedicularis densiflora | Indian warrior |
| Kavalactones | Piper methysticum | An anxiolytic and hypnotic. Often advertised as a 'healthier' alternative to alcohol. |
| Ergine | Rivea corymbosa | Seeds contain ergine, lysergol, and turbicoryn; lysergic acid alkaloids up to 0.03% Has psychedelic properties. |
| Salvinorin A | Salvia divinorum | Salvinorin A, 0.89–3.87 mg/g, also Salvinorin B and Salvinorin C |
| Mesembrine | Sceletium tortuosum | Kanna |
| Baicalein | Scutellaria | Known commonly as 'skullcaps'. Baicalein is a positive allosteric modulator of GABA$_A$ receptor. |
| Unknown | Sessea | S. brasiliensis poisoning is described as very similar to that of Cestrum laevigatum; a species used to induce hallucinations by the Krahô tribe for spiritual purposes. |
| Unknown | Silene capensis | Produces vivid dreams after smoking. |
| Unknown | Tagetes lucida | Anethole, Chavicol, Coumarin, Estragole, Isorhamnetin, Methyleugenol, Quercitin |
| Ibogaine | Tabernanthe iboga | Ibogaine in root bark. Produces psychedelic and a dissociative effects. |
| Ibogaine | Tabernanthe orientalis | Ibogaine in root leaves. Produces psychedelic and a dissociative effects. |
| Voacangine, Ibogaine | Tabernaemontana divaricata | Is a psychedelic and a dissociative. |
| Ibogaine | Tabernanthe pubescens | Is a psychedelic and a dissociative. Contains ibogaine and similar alkaloids. |
| Ibogaine | Tabernaemontana sp. | Is a psychedelic and a dissociative. |
| Theobromine | Theobroma cacao | Cocoa or cacao bean, chocolate, native to the Americas |
| Ibogaine | Trachelospermum jasminoides | Exhibits psychedelic and dissociative effects. Contains ibogaine, coronaridine, voacangine, apparicine, conoflorine, and 19-epi-voacangarine. |
| Valerenic acid | Valeriana officinalis | Possible sedative and anxiolytic effects. Valerenic acid is GABA$_A$ receptor positive allosteric modulator, and a 5-HT$_{5A}$ receptor partial agonist. |
| Vincamine | Vinca minor | Vincamine. |
| Voacangine | Voacanga africana | Voacangine is similar in structure to ibogaine. It inhibits AChE. |
| Dendrobine | Dendrobium nobile | Also contains phenanthrenes and dendrobine related alkaloids. |
| Possibly Genistein and Apigenin | Zornia latifolia | Zornia latifolia is sometimes combined with synthetic cannabis. It may produce similar effects to cannabis. It is nicknamed Maconha brava because locals use it as a cannabis substitute. |