# 2021 Conference USA football season

The 2021 Conference USA football season was the 26th season of college football play for Conference USA (C-USA). The season started on August 28, 2021 and ended on December 23, 2021. The conference consisted of 14 members in two divisions. It was part of the 2021 NCAA Division I FBS football season.

## Previous season

Due to the COVID-19 pandemic, Old Dominion did not play the 2020 season, leaving the conference with 13 participating teams. The rest of the conference played the full season, with some games postponed or cancelled for reasons relating to the pandemic. The Marshall Thundering Herd won the East Division, while the UAB Blazers won the West Division. In the 2020 Conference USA Football Championship Game, the Blazers defeated the Thundering Herd 22–13.

## Preseason
### Preseason Media Poll

The Preseason Media Poll was released on July 19. Marshall was voted the favorite to win the East Division, while UAB was voted favorite for the West Division.

### Preseason player awards

Preseason player awards were announced on July 20.
* Offensive Player of the Year: Sincere McCormick (Junior, UTSA runningback)
* Defensive Player of the Year: DeAngelo Malone (Senior, Western Kentucky defensive back)
* Special Teams Player of the Year: Lucas Dean (Junior, UTSA punter)

### Preseason awards

The following list contains C-USA players who were included on preseason watch lists for national awards.
| Award | Head coach/Player | School | Position |
| Maxwell Award | Chris Reynolds | Charlotte | QB |
| Maxwell Award | Grant Wells | Marshall | QB |
| Maxwell Award | Frank Gore Jr. | Southern Miss | RB |
| Maxwell Award | Sincere McCormick | UTSA | RB |
| Bednarik Award | Tyler Grubbs | Louisiana Tech | LB |
| Bednarik Award | Reed Blankenship | Middle Tennessee | S |
| Bednarik Award | Kris Moll | UAB | LB |
| Bednarik Award | Praise Amaewhule | UTEP | DE |
| Bednarik Award | Rashad Wisdom | UTSA | S |
| Bednarik Award | DeAngelo Malone | Western Kentucky | DE |
| Davey O'Brien Award | Frank Harris | UTSA | QB |
| Davey O'Brien Award | Grant Wells | Marshall | QB |
| Doak Walker Award | Frank Gore Jr. | Southern Miss | RB |
| Doak Walker Award | DeWayne McBride | UAB | RB |
| Doak Walker Award | Sincere McCormick | UTSA | RB |
| Fred Biletnikoff Award | Jacob Cowing | UTEP | WR |
| Fred Biletnikoff Award | Zakhari Franklin | UTSA | WR |
| Fred Biletnikoff Award | Bradley Rozner | Rice | WR |
| John Mackey Award | Joshua Simon | Western Kentucky | TE |
| John Mackey Award | Hayden Pittman | UAB | TE |
| John Mackey Award | Leroy Watson | UTSA | TE |
| Rimington Trophy | Alex Salguero | Marshall | C |
| Outland Trophy | Spencer Burford | UTSA | OT |
| Outland Trophy | Colby Ragland | UAB | OT |
| Outland Trophy | Sidney Wells | UAB | OT |
| Bronko Nagurski Trophy | Jamare Edwards | Marshall | DT |
| Bronko Nagurski Trophy | Tyler Grubbs | Louisiana Tech | LB |
| Bronko Nagurski Trophy | DeAngelo Malone | Western Kentucky | DE |
| Bronko Nagurski Trophy | Kris Moll | UAB | LB |
| Bronko Nagurski Trophy | Dion Novil | North Texas | DT |
| Lou Groza Award | Jacob Barnes | Louisiana Tech | K |
| Lou Groza Award | Hunter Duplessis | UTSA | K |
| Lou Groza Award | Brayden Narveson | Western Kentucky | K |
| Lou Groza Award | Matt Quinn | UAB | K |
| Paul Hornung Award | Jacob Adams | Louisiana Tech | FB |
| Paul Hornung Award | Jake Bailey | Rice | WR |
| Paul Hornung Award | Jermaine Brown Jr. | UAB | RB |
| Paul Hornung Award | DeAndre Torrey | North Texas | RB |
| Wuerffel Trophy | Peter Agabe | Charlotte | LB |
| Wuerffel Trophy | Joshua Mate | Louisiana Tech | OL |
| Wuerffel Trophy | Reeves Blankenship | Louisiana Tech | LS |
| Wuerffel Trophy | Alex Mollette | Marshall | OL |
| Wuerffel Trophy | Reed Blankeship | Middle Tennessee | S |
| Wuerffel Trophy | Jordan Young | Old Dominion | LB |
| Wuerffel Trophy | Ikenna Enechukwu | Rice | DL |
| Wuerffel Trophy | Colby Ragland | UAB | OL |
| Wuerffel Trophy | Hunter Duplessis | UTSA | K |
| Walter Camp Award | Sincere McCormick | UTSA | RB |
| Manning Award | Frank Harris | UTSA | QB |
| Earl Campbell Tyler Rose Award | Deion Hankins | UTEP | RB |
| Earl Campbell Tyler Rose Award | Sincere McCormick | UTSA | RB |
| Earl Campbell Tyler Rose Award | Jordan Myers | Rice | TE |
| Earl Campbell Tyler Rose Award | Bailey Zappe | Western Kentucky | QB |
| Ray Guy Award | Bernardo Rodriguez | North Texas | P |
| Ray Guy Award | Cesar Barajas | Louisiana Tech | P |
| Ray Guy Award | Jacob Barnes | Louisiana Tech | K |
| Ray Guy Award | John Haggerty | Western Kentucky | P |
| Ray Guy Award | Kyle Greenwell | UAB | P |
| Ray Guy Award | Kyle Ulbrich | Middle Tennessee | P |
| Ray Guy Award | Lucas Dean | UTSA | P |
| Ray Guy Award | Matthew Hayball | Florida Atlantic | P |
| Ray Guy Award | Tommy Heatherly | FIU | P |
| Polynesian College Football Player Of The Year Award | Ahofitu Maka | UTSA | OL |
| Polynesian College Football Player Of The Year Award | Manase Mose | North Texas | OL |
| Johnny Unitas Golden Arm Award | Luke Anthony | Louisiana Tech | QB |
| Johnny Unitas Golden Arm Award | Bailey Hockman | Middle Tennessee | QB |
| Johnny Unitas Golden Arm Award | Tyler Johnston III | UAB | QB |
| Johnny Unitas Golden Arm Award | Chris Reynolds | Charlotte | QB |

## Head coaches

Doc Holliday was released from the Head Coach position at Marshall after 11 seasons with the program. He was replaced by Charles Huff, who had previously been the running backs coach at Alabama.
Will Hall took over as the new permanent Head Coach at Southern Miss, filling the vacancy left after Jay Hopson had resigned one game into the previous season.
Note: All stats shown are before the start of the 2021 season.
| Team | Head coach | Years at school | Overall record | Record at school | CUSA Record |
| Charlotte | Will Healy | 3 | 22–31 | 9–10 | 7–5 |
| FIU | Butch Davis | 4 | 86–64 | 23-21 | 14–13 |
| Florida Atlantic | Willie Taggart | 2 | 61–66 | 5–4 | 4–2 |
| Louisiana Tech | Skip Holtz | 9 | 149–112 | 61–41 | 41–21 |
| Marshall | Charles Huff | 1 | 0–0 | 0–0 | 0–0 |
| Middle Tennessee | Rick Stockstill | 16 | 94–92 | 94–92 | 71–45 |
| North Texas | Seth Littrell | 6 | 31–31 | 31–31 | 21–18 |
| Old Dominion | Ricky Rahne | 2 | 0–0 | 0–0 | 0–0 |
| Rice | Mike Bloomgren | 4 | 7–23 | 7–23 | 6–15 |
| Southern Miss | Will Hall | 1 | 56–20 | 0–0 | 0–0 |
| UAB | Bill Clark | 6 | 51–26 | 40–22 | 26–10 |
| UTEP | Dana Dimel | 4 | 35–66 | 5–27 | 1–19 |
| UTSA | Jeff Traylor | 2 | 7–5 | 7–5 | 5–2 |
| Western Kentucky | Tyson Helton | 3 | 14–11 | 14–11 | 10–5 |

### Post-season changes

* On November 10, Butch Davis announced that he would not return to FIU after the school declined to extend his contract.
* On November 26, Louisiana Tech announced that they were firing head coach Skip Holtz. Holtz was allowed to coach the final game of the season before being dismissed immediately after. The school announced on November 30 that Texas Tech offensive coordinator Sonny Cumbie would take over as the new head coach.

## Rankings

| | | Pre | Wk 1 | Wk 2 | Wk 3 | Wk 4 | Wk 5 | Wk 6 | Wk 7 | Wk 8 | Wk 9 | Wk 10 | Wk 11 | Wk 12 | Wk 13 | Wk 14 | Final |
| Charlotte | AP | | | | | | | | | | | | | | | | |
| Charlotte | C | | RV | | | | | | | | | | | | | | |
| Charlotte | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| FIU | AP | | | | | | | | | | | | | | | | |
| FIU | C | | | | | | | | | | | | | | | | |
| FIU | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Florida Atlantic | AP | | | | | | | | | | | | | | | | |
| Florida Atlantic | C | | | | | | | | | | | | | | | | |
| Florida Atlantic | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Louisiana Tech | AP | | | | | | | | | | | | | | | RV | |
| Louisiana Tech | C | | | | | | | | | | | | | | | | |
| Louisiana Tech | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Marshall | AP | | | | | | | | | | | | | | | | |
| Marshall | C | RV | RV | RV | | | | | | | | | | | | | |
| Marshall | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Middle Tennessee | AP | | | | | | | | | | | | | | | | |
| Middle Tennessee | C | | | | | | | | | | | | | | | | |
| Middle Tennessee | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| North Texas | AP | | | | | | | | | | | | | | | | |
| North Texas | C | | | | | | | | | | | | | | | | |
| North Texas | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Old Dominion | AP | | | | | | | | | | | | | | | | |
| Old Dominion | C | | | | | | | | | | | | | | | | |
| Old Dominion | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Rice | AP | | | | | | | | | | | | | | | | |
| Rice | C | | | | | | | | | | | | | | | | |
| Rice | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| Southern Miss | AP | | | | | | | | | | | | | | | | |
| Southern Miss | C | | | | | | | | | | | | | | | | |
| Southern Miss | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| UAB | AP | RV | RV | | | | | | | | | | | | | | RV |
| UAB | C | RV | RV | | | | | | | | | | | | | | |
| UAB | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| UTEP | AP | | | | | | | | | | | | | | | | |
| UTEP | C | | | | | | | | | | | | | | | | |
| UTEP | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
| UTSA | AP | | | | | RV | RV | RV | 24 | 23 | 16 | 15 | 15 | 15 | RV | 24 | RV |
| UTSA | C | | | RV | RV | RV | RV | RV | 25 | 22 | 18 | 16 | 18 | 20 | RV | 25 | RV |
| UTSA | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | 23 | 22 | 22 | | | |
| Western Kentucky | AP | | | | | | | | | | | | | | | | |
| Western Kentucky | C | | | | | | | | | | | | | | | | |
| Western Kentucky | CFP | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | Not released | | | | | | | |
Legend :
| | Improvement in ranking |
| | Drop in ranking |
| | Not ranked previous week |
| | No change in ranking from previous week |
| RV | Received votes but were not ranked in Top 25 of poll |
| т | Tied with team above or below also with this symbol |

## Schedule

* Index to colors and formatting
* C-USA member won
* C-USA member lost
* C-USA teams in bold
All times Eastern time.

### Week 0

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance | Ref. |
| August 28 | 9:30 p.m. | UTEP | New Mexico State | Aggie Memorial Stadium • Las Cruces, NM (Battle of I-10) | BZAZ/FloSports | W 30–3 | 19,034 | |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 1

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| September 1 | 7:30 p.m. | UAB | No. 10 (FCS) Jacksonville State | Cramton Bowl • Montgomery, AL | ESPN | W 31–0 | 9,122 |
| September 2 | 7:00 p.m. | LIU | FIU | Riccardo Silva Stadium • Miami, FL | ESPN3 | W 48–10 | |
| September 2 | 8:00 p.m. | UT Martin | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | ESPN+ | W 59–21 | 16,236 |
| September 3 | 7:00 p.m. | Old Dominion | Wake Forest | Truist Field • Winston-Salem, NC | ACCN | L 10–42 | 25,673 |
| September 3 | 7:00 p.m. | Duke | Charlotte | Jerry Richardson Stadium • Charlotte, NC | CBSSN | W 31–28 | 14,125 |
| September 4 | 2:00 p.m. | Rice | Arkansas | Donald W. Reynolds Razorback Stadium • Fayetteville, AR | ESPN+/SECN+ | L 17–38 | 64,065 |
| September 4 | 3:30 p.m. | Marshall | Navy | Navy–Marine Corps Memorial Stadium • Annapolis, MD | CBSSN | W 49–7 | 30,131 |
| September 4 | 4:00 p.m. | Louisiana Tech | Mississippi State | Davis Wade Stadium • Starkville, MS | ESPNU | L 34–35 | 44,669 |
| September 4 | 7:00 p.m. | No. 13 (FCS) Monmouth | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | ESPN3 | W 50–15 | 15,017 |
| September 4 | 7:30 p.m. | Florida Atlantic | No. 13 Florida | Ben Hill Griffin Stadium • Gainesville, FL | SECN | L 14–35 | 86,840 |
| September 4 | 7:30 p.m. | Northwestern State | North Texas | Apogee Stadium • Denton, TX | ESPN3 | W 44–14 | 18,716 |
| September 4 | 7:30 p.m. | UTSA | Illinois | Memorial Stadium • Champaign, IL | BTN | W 37–30 | 33,906 |
| September 4 | 8:00 p.m. | Southern Miss | South Alabama | Hancock Whitney Stadium • Mobile, AL | ESPN+ | L 7–31 | 20,156 |
| September 4 | 9:00 p.m. | Bethune–Cookman | UTEP | Sun Bowl • El Paso, TX | ESPN3 | W 38–28 | 14,554 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 2

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| September 10 | 9:30 p.m. | UTEP | Boise State | Albertsons Stadium • Boise, ID | FS1 | L 13–54 | 35,518 |
| September 11 | 11:30 a.m. | Western Kentucky | Army | Michie Stadium • West Point, NY | CBSSN | L 35–38 | 25,989 |
| September 11 | 2:00 p.m. | Middle Tennessee | No. 19 Virginia Tech | Lane Stadium • Blacksburg, VA | ACCNX | L 14–35 | 53,680 |
| September 11 | 3:30 p.m. | UAB | No. 2 Georgia | Sanford Stadium • Athens, GA | ESPN2 | L 7–56 | 92,746 |
| September 11 | 3:30 p.m. | Georgia Southern | Florida Atlantic | FAU Stadium • Boca Raton, FL | Stadium | W 38–6 | 17,736 |
| September 11 | 6:00 p.m. | Gardner–Webb | Charlotte | Jerry Richardson Stadium • Charlotte, NC | ESPN3 | W 38–10 | 12,274 |
| September 11 | 6:00 p.m. | Lamar | UTSA | Alamodome • San Antonio, TX | ESPN+ | W 54–0 | 16,229 |
| September 11 | 6:30 p.m. | Houston | Rice | Rice Stadium • Houston, TX (rivalry) | CBSSN | L 7–44 | 26,253 |
| September 11 | 6:30 p.m. | North Carolina Central | Marshall | Joan C. Edwards Stadium • Huntington, WV | ESPN+ | W 44–10 | 24,521 |
| September 11 | 7:00 p.m. | North Texas | SMU | Gerald J. Ford Stadium • Dallas, TX (Safeway Bowl) | ESPN+ | L 12–35 | 29,121 |
| September 11 | 7:00 p.m. | No. 13 (FCS) Southeastern Louisiana | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | ESPN3 | W 45–42 | 15,328 |
| September 11 | 7:00 p.m. | Texas State | FIU | Riccardo Silva Stadium • Miami, FL | ESPN+ | L 17–23 $^{OT}$ | |
| September 11 | 7:00 p.m. | Hampton | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | ESPN3 | W 47–7 | 18,363 |
| September 11 | 7:00 p.m. | Grambling State | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | ESPN3 | W 37–0 | 25,235 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 3

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| September 18 | 3:30 p.m. | SMU | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | CBSSN | L 37–39 | 15,329 |
| September 18 | 6:00 p.m. | East Carolina | Marshall | Joan C. Edwards Stadium • Huntington, WV (rivalry) | Facebook | L 38–42 | 24,833 |
| September 18 | 6:00 p.m. | Fordham | Florida Atlantic | FAU Stadium • Boca Raton, FL | ESPN3 | W 45–14 | 17,132 |
| September 18 | 6:00 p.m. | Old Dominion | Liberty | Williams Stadium • Lynchburg, VA | ESPN3 | L 17–45 | 18,471 |
| September 18 | 6:00 p.m. | Middle Tennessee | UTSA | Alamodome • San Antonio, Texas | ESPN+ | UTSA 27–13 | 16,202 |
| September 18 | 7:00 p.m. | Charlotte | Georgia State | Center Parc Stadium • Atlanta, GA | ESPN+ | L 9–20 | 12,978 |
| September 18 | 7:00 p.m. | FIU | Texas Tech | Jones AT&T Stadium • Lubbock, TX | ESPN+ | L 21–54 | 50,118 |
| September 18 | 7:00 p.m. | Troy | Southern Miss | M. M. Roberts Stadium • Hattiesburg, Mississippi | ESPN+ | L 9–21 | 24,242 |
| September 18 | 7:30 p.m. | UAB | North Texas | Apogee Stadium • Denton, TX | Stadium | UAB 40–6 | 17,731 |
| September 18 | 8:00 p.m. | Rice | Texas | Darrell K Royal–Texas Memorial Stadium • Austin, TX (rivalry) | LHN | L 0–58 | 91,978 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 4

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| September 23 | 7:30 p.m. | Marshall | Appalachian State | Kidd Brewer Stadium • Boone, NC | ESPN | L 30–31 | 28,377 |
| September 24 | 6:30 p.m. | Middle Tennessee | Charlotte | Jerry Richardson Stadium • Charlotte, NC | CBSSN | CHAR 42–39 | 11,076 |
| September 25 | 12:00 p.m. | FIU | Central Michigan | Kelly/Shorts Stadium • Mount Pleasant, MI | ESPN+ | L 27–31 | 30,255 |
| September 25 | 3:30 p.m. | UTSA | Memphis | Liberty Bowl Memorial Stadium • Memphis, TN | ESPNU | W 31–28 | 29,264 |
| September 25 | 6:00 p.m. | Buffalo | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | ESPN+ | L 34–35 | |
| September 25 | 6:30 p.m. | Texas Southern | Rice | Rice Stadium • Houston, TX | ESPN3 | W 48–34 | 18,326 |
| September 25 | 7:00 p.m. | North Texas | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | Stadium | LT 24–17 | 15,488 |
| September 25 | 7:30 p.m. | Southern Miss | No. 1 Alabama | Bryant–Denny Stadium • Tuscaloosa, AL | SECN | L 14–63 | 100,077 |
| September 25 | 8:00 p.m. | Florida Atlantic | Air Force | Falcon Stadium • Colorado Springs, CO | FS2 | L 7–31 | 19,763 |
| September 25 | 8:00 p.m. | UAB | Tulane | Yulman Stadium • New Orleans, LA | ESPN+ | W 28–21 | 16,023 |
| September 25 | 8:00 p.m. | Indiana | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | CBSSN | L 31–33 | 25,171 |
| September 25 | 9:00 p.m. | New Mexico | UTEP | Sun Bowl • El Paso, TX | ESPN+ | W 20–13 | 15,069 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 5

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| October 2 | 12:00 p.m. | Charlotte | Illinois | Memorial Stadium • Champaign, IL | BTN | L 14–24 | 30,559 |
| October 2 | 3:30 p.m. | FIU | Florida Atlantic | FAU Stadium • Boca Raton, FL (Shula Bowl) | Stadium | FAU 58–21 | 24,726 |
| October 2 | 6:00 p.m. | Louisiana Tech | No. 23 NC State | Carter–Finley Stadium • Raleigh, NC | ACCN/ESPN+ | L 27–34 | 51,064 |
| October 2 | 6:00 p.m. | UNLV | UTSA | Alamodome • San Antonio, TX | ESPN+ | W 24–17 | 20,154 |
| October 2 | 6:30 p.m. | Southern Miss | Rice | Rice Stadium • Houston, TX | ESPN3 | RICE 24–19 | 16,031 |
| October 2 | 7:00 p.m. | Liberty | UAB | Protective Stadium • Birmingham, AL | CBSSN | L 12–36 | 37,167 |
| October 2 | 7:00 p.m. | Marshall | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | Stadium | MTSU 34–28 | 15,806 |
| October 2 | 7:30 p.m. | Western Kentucky | No. 17 Michigan State | Spartan Stadium • East Lansing, MI | BTN | L 31–48 | 70,075 |
| October 2 | 9:00 p.m. | Old Dominion | UTEP | Sun Bowl • El Paso, TX | ESPN+ | UTEP 28–21 | 11,025 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 6

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| October 8 | 7:00 p.m. | Charlotte | FIU | Riccardo Silva Stadium • Miami, FL | CBSSN | CHAR 45–33 | |
| October 9 | 2:00 p.m. | Old Dominion | Marshall | Joan C. Edwards Stadium • Huntington, WV | Facebook | MU 20–13 $^{OT}$ | 24,172 |
| October 9 | 3:30 p.m. | Florida Atlantic | UAB | Protective Stadium • Birmingham, AL | Stadium | UAB 31–14 | 25,191 |
| October 9 | 3:30 p.m. | Middle Tennessee | Liberty | Williams Stadium • Lynchburg, VA | ESPN3 | L 13–41 | 19,935 |
| October 9 | 4:00 p.m. | North Texas | Missouri | Faurot Field • Columbia, MO | SECN | L 35–48 | 46,985 |
| October 9 | 7:00 p.m. | UTEP | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | ESPN3 | UTEP 26–13 | 26,049 |
| October 9 | 7:00 p.m. | UTSA | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | Stadium | UTSA 52–46 | 15,243 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 7

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| October 15 | 7:00 p.m. | Marshall | North Texas | Apogee Stadium • Denton, TX | CBSSN | MU 49–21 | 13,123 |
| October 16 | 3:30 p.m. | UAB | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | Stadium | UAB 34–0 | 21,514 |
| October 16 | 3:30 p.m. | Western Kentucky | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | ESPN3 | WKU 43–20 | 16,418 |
| October 16 | 6:00 p.m. | Rice | UTSA | Alamodome • San Antonio, TX | ESPN+ | UTSA 45–0 | 27,515 |
| October 16 | 9:00 p.m. | Louisiana Tech | UTEP | Sun Bowl • El Paso, TX | ESPN+ | UTEP 19–3 | 18,468 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 8

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| October 21 | 7:30 p.m. | Florida Atlantic | Charlotte | Jerry Richardson Stadium • Charlotte, NC | CBSSN | FAU 38-9 | 13,017 |
| October 22 | 6:00 p.m. | Middle Tennessee | UConn | Rentschler Field • East Hartford, CT | CBSSN | W 44–13 | 10,698 |
| October 23 | 3:30 p.m. | Rice | UAB | Protective Stadium • Birmingham, AL | ESPN+ | RICE 30–24 | 24,845 |
| October 23 | 4:00 p.m. | Liberty | North Texas | Apogee Stadium • Denton, TX | ESPN+ | L 26–35 | 13,454 |
| October 23 | 7:00 p.m. | No. 24 UTSA | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | Stadium | UTSA 45–16 | 18,314 |
| October 23 | 7:00 p.m. | Western Kentucky | FIU | Riccardo Silva Stadium • Miami, Florida | ESPN+ | WKU 34–19 | |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 9

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| October 30 | 2:00 p.m. | North Texas | Rice | Rice Stadium • Houston, TX | ESPN3 | UNT 30–24 $^{OT}$ | 17,354 |
| October 30 | 3:30 p.m. | FIU | Marshall | Joan C. Edwards Stadium • Huntington, WV | Stadium | MU 38–0 | 18,466 |
| October 30 | 3:30 p.m. | Louisiana Tech | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | CBSSN | ODU 23–20 | 13,309 |
| October 30 | 3:30 p.m. | Southern Miss | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | ESPN+ | MTSU 35–10 | 10,721 |
| October 30 | 4:00 p.m. | Charlotte | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | ESPN+ | WKU 45–13 | 16,763 |
| October 30 | 6:00 p.m. | UTEP | Florida Atlantic | FAU Stadium • Boca Raton, FL | ESPN+ | FAU 28–25 | 16,432 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 10

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| November 6 | 12:00 p.m. | Louisiana Tech | UAB | Protective Stadium • Birmingham, AL | CBSSN | UAB 52–38 | 21,261 |
| November 6 | 3:00 p.m. | North Texas | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | ESPN+ | UNT 38–14 | 22,478 |
| November 6 | 3:30 p.m. | Middle Tennessee | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY (100 Miles of Hate) | Stadium | WKU 48–21 | 15,022 |
| November 6 | 3:30 p.m. | Rice | Charlotte | Jerry Richardson Stadium • Charlotte, NC | ESPN+ | CHAR 31–24 $^{OT}$ | 16,050 |
| November 6 | 6:00 p.m. | Marshall | Florida Atlantic | FAU Stadium • Boca Raton, FL | Facebook | MU 28–13 | 21,803 |
| November 6 | 7:00 p.m. | Old Dominion | FIU | Riccardo Silva Stadium • Miami, FL | ESPN3 | ODU 47–24 | 0 |
| November 6 | 10:15 p.m. | No. 16 UTSA | UTEP | Sun Bowl • El Paso, TX | ESPN2 | UTSA 44–23 | 31,658 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 11

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| November 13 | 2:00 p.m. | Western Kentucky | Rice | Rice Stadium • Houston, TX | ESPN+ | WKU 42–21 | 17,883 |
| November 13 | 3:30 p.m. | Charlotte | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | Stadium | LT 42–32 | 14,068 |
| November 13 | 3:30 p.m. | FIU | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | ESPN3 | MTSU 50–10 | 10,606 |
| November 13 | 3:30 p.m. | Florida Atlantic | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | ESPN+ | ODU 30–16 | 13,634 |
| November 13 | 3:30 p.m. | Southern Miss | No. 15 UTSA | Alamodome • San Antonio, TX | ESPN+ | UTSA 27–17 | 30,105 |
| November 13 | 3:30 p.m. | UAB | Marshall | Joan C. Edwards Stadium • Huntington, WV | CBSSN | UAB 21–14 | 19,329 |
| November 13 | 4:00 p.m. | UTEP | North Texas | Apogee Stadium • Denton, TX | ESPN+ | UNT 20–17 | 20,056 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 12

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| November 19 | 8:00 p.m. | Southern Miss | Louisiana Tech | Joe Aillet Stadium • Ruston, LA (Rivalry in Dixie) | CBSSN | USM 35–19 | 10,410 |
| November 20 | 12:00 p.m. | Florida Atlantic | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | Stadium | WKU 52–17 | 10,477 |
| November 20 | 3:30 p.m. | Marshall | Charlotte | Jerry Richardson Stadium • Charlotte, NC | Stadium | MU 49–28 | 13,211 |
| November 20 | 3:30 p.m. | Old Dominion | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | ESPN+ | ODU 24–17 | 9,606 |
| November 20 | 3:30 p.m. | UAB | No. 15 UTSA | Alamodome • San Antonio, TX | ESPN+ | UTSA 34–31 | 35,147 |
| November 20 | 4:00 p.m. | Rice | UTEP | Sun Bowl • El Paso, TX | ESPN+ | UTEP 38–28 | 10,097 |
| November 20 | 7:00 p.m. | North Texas | FIU | Riccardo Silva Stadium • Miami, FL | ESPN3 | UNT 49–7 | |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Week 13

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance |
| November 26 | 2:00 p.m. | UTEP | UAB | Protective Stadium • Birmingham, AL | ESPN+ | UAB 42–25 | 19,683 |
| November 27 | 1:00 p.m. | Louisiana Tech | Rice | Rice Stadium • Houston, TX | ESPN+ | RICE 35–31 | |
| November 27 | 2:00 p.m. | Charlotte | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | ESPN+ | ODU 56–34 | 15,874 |
| November 27 | 2:00 p.m. | No. 15 UTSA | North Texas | Apogee Stadium • Denton, TX | ESPN+ | UNT 45–23 | 16,933 |
| November 27 | 3:00 p.m. | FIU | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | ESPN+ | USM 37–17 | 20,041 |
| November 27 | 3:30 p.m. | Western Kentucky | Marshall | Joan C. Edwards Stadium • Huntington, WV | CBSSN | WKU 53–21 | 19,134 |
| November 27 | 7:00 p.m. | Middle Tennessee | Florida Atlantic | FAU Stadium • Boca Raton, FL | Stadium | MTSU 27–17 | 15,127 |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

### Conference USA Championship Game

| Date | Time | Visiting team | Home team | Site | TV | Result | Attendance | Ref. |
| December 3 | 7:00 p.m. | Western Kentucky | UTSA | Alamodome • San Antonio, TX | CBSSN | UTSA 49–41 | 41,148 | |
| $^#$Rankings from AP Poll released prior to game. All times are in Eastern Time. |||||||||

## Postseason
### Bowl Games

Legend :
* C-USA Win
* C-USA Loss
| Bowl game | Date | Site | Television | Time (EST) | C-USA team | Opponent | Score | Attendance |
| Bahamas Bowl | December 17 | Thomas Robinson Stadium • Nassau, Bahamas | ESPN | 12:00 p.m. | Middle Tennessee | Toledo | W 31–24 | 13,596 |
| Boca Raton Bowl | December 18 | FAU Stadium • Boca Raton, FL | ESPN | 11:00 a.m. | Western Kentucky | Appalachian State | W 59–38 | 15,429 |
| New Mexico Bowl | December 18 | University Stadium • Albuquerque, NM | ESPN | 2:15 p.m. | UTEP | Fresno State | L 24–31 | 16,422 |
| Independence Bowl | December 18 | Independence Stadium • Shreveport, LA | ABC | 3:30 p.m. | UAB | No. 13 BYU | W 31–28 | 26,276 |
| New Orleans Bowl | December 18 | Caesars Superdome • New Orleans, LA | ESPN | 9:15 p.m. | Marshall | No. 23 Louisiana | L 21–36 | 21,642 |
| Myrtle Beach Bowl | December 20 | Brooks Stadium • Conway, SC | ESPN | 2:30 p.m. | Old Dominion | Tulsa | L 17–30 | 6,557 |
| Frisco Bowl | December 21 | Toyota Stadium • Frisco, TX | ESPN | 7:30 p.m. | UTSA | San Diego State | L 24–38 | 15,801 |
| Frisco Football Classic | December 23 | Toyota Stadium • Frisco, TX | ESPN | 3:30 p.m. | North Texas | Miami (OH) | L 14–27 | 11,721 |

## Conference USA records vs other conferences

2021–2022 records against non-conference foes:
| Power Conferences 5 | Record |
| ACC | 1–3 |
| Big Ten | 1–3 |
| Big 12 | 0–2 |
| Pac-12 | 0–0 |
| BYU/Notre Dame | 0–0 |
| SEC | 0–6 |
| Power 5 Total | 2–14 |
| Other FBS Conferences | Record |
| American | 3–4 |
| Independents (Excluding Notre Dame and BYU) | 2–5 |
| MAC | 0–2 |
| Mountain West | 2–2 |
| Sun Belt | 1–5 |
| Other FBS Total | 8–18 |
| FCS Opponents | Record |
| Football Championship Subdivision | 14–0 |
| Total Non-Conference Record | 24–32 |

### Conference USA vs Power 5 matchups

This is a list of games C-USA has scheduled versus power conference teams (ACC, Big 10, Big 12, Pac-12, BYU, Notre Dame and SEC). All rankings are from the current AP Poll at the time of the game.
| Date | Conference | Visitor | Home | Site | Score |
| September 3 | ACC | Old Dominion | Wake Forest | Truist Field • Winston-Salem, NC | L 10–42 |
| September 3 | ACC | Duke | Charlotte | Jerry Richardson Stadium • Charlotte, NC | W 31–28 |
| September 4 | SEC | Rice | Arkansas | Donald W. Reynolds Razorback Stadium • Fayetteville, AR | L 17–38 |
| September 4 | SEC | Louisiana Tech | Mississippi State | Davis Wade Stadium • Starkville, MS | L 34–35 |
| September 4 | SEC | Florida Atlantic | No. 13 Florida | Ben Hill Griffin Stadium • Gainesville, FL | L 14–35 |
| September 4 | Big Ten | UTSA | Illinois | Memorial Stadium • Champaign, IL | W 37–30 |
| September 11 | ACC | Middle Tennessee | No. 19 Virginia Tech | Lane Stadium • Blacksburg, VA | L 14–35 |
| September 11 | SEC | UAB | No. 2 Georgia | Sanford Stadium • Athens, GA | L 7–56 |
| September 18 | Big 12 | FIU | Texas Tech | Jones AT&T Stadium • Lubbock, TX | L 21–54 |
| September 18 | Big 12 | Rice | Texas | Darrell K Royal–Texas Memorial Stadium • Austin, TX | L 0–58 |
| September 25 | Big Ten | Indiana | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | L 31–33 |
| September 25 | SEC | Southern Miss | No. 1 Alabama | Bryant–Denny Stadium • Tuscaloosa, AL | L 14–63 |
| October 2 | Big Ten | Western Kentucky | No. 17 Michigan State | Spartan Stadium • East Lansing, MI | L 31–48 |
| October 2 | ACC | Louisiana Tech | No. 23 NC State | Carter–Finley Stadium • Raleigh, NC | L 27–34 |
| October 2 | Big Ten | Charlotte | Illinois | Memorial Stadium • Champaign, IL | L 14–24 |
| October 9 | SEC | North Texas | Missouri | Farout Field • Columbia, MO | L 35–48 |

### Conference USA vs Group of Five matchups

The following games include C-USA teams competing against teams from the American, MAC, Mountain West, or Sun Belt.
| Date | Conference | Visitor | Home | Site | Score |
| September 4 | American | Marshall | Navy | Navy–Marine Corps Memorial Stadium • Annapolis, MD | W 49–7 |
| September 4 | Sun Belt | Southern Miss | South Alabama | Hancock Whitney Stadium • Mobile, AL | L 7–31 |
| September 10 | Mountain West | UTEP | Boise State | Albertsons Stadium • Boise, ID | L 13–54 |
| September 11 | Sun Belt | Georgia Southern | Florida Atlantic | FAU Stadium • Boca Raton, FL | W 38–6 |
| September 11 | American | Houston | Rice | Rice Stadium • Houston, TX | L 7–44 |
| September 11 | American | North Texas | SMU | Gerald J. Ford Stadium • Dallas, TX | L 12–35 |
| September 11 | Sun Belt | Texas State | FIU | Riccardo Silva Stadium • Miami, FL | L 17–23 $^{OT}$ |
| September 18 | American | SMU | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | L 37–39 |
| September 18 | American | East Carolina | Marshall | Joan C. Edwards Stadium • Huntington, WV | L 38–42 |
| September 18 | Sun Belt | Charlotte | Georgia State | Center Parc Stadium • Atlanta, GA | L 9–20 |
| September 18 | Sun Belt | Troy | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | L 9–21 |
| September 23 | Sun Belt | Marshall | Appalachian State | Kidd Brewer Stadium • Boone, NC | L 30–31 |
| September 25 | MAC | Buffalo | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | L 34–35 |
| September 25 | Mountain West | New Mexico | UTEP | Sun Bowl • El Paso, TX | W 20–13 |
| September 25 | MAC | FIU | Central Michigan | Kelly/Shorts Stadium • Mount Pleasant, MI | L 27–31 |
| September 25 | American | UAB | Tulane | Yulman Stadium • New Orleans, LA | W 28–21 |
| September 25 | American | UTSA | Memphis | Liberty Bowl Memorial Stadium • Memphis, TN | W 31–28 |
| September 25 | Mountain West | Florida Atlantic | Air Force | Falcon Stadium • Colorado Spring, CO | L 7–31 |
| October 2 | Mountain West | UNLV | UTSA | Alamodome • San Antonio, TX | W 24–17 |

### Conference USA vs FBS independents matchups

The following games include C-USA teams competing against FBS Independents, which includes Army, Liberty, New Mexico State, UConn, or UMass.
| Date | Conference | Visitor | Home | Site | Score |
| August 28 | Independent | UTEP | New Mexico State | Aggie Memorial Stadium • Las Cruces, NM | W 30–3 |
| September 11 | Independent | Western Kentucky | Army | Michie Stadium • West Point, NY | L 35–38 |
| September 18 | Independent | Old Dominion | Liberty | Williams Stadium • Lynchburg, VA | L 17–45 |
| October 2 | Independent | Liberty | UAB | Protective Stadium • Birmingham, AL | L 12–36 |
| October 9 | Independent | Middle Tennessee | Liberty | Williams Stadium • Lynchburg, VA | L 13–41 |
| October 22 | Independent | Middle Tennessee | UConn | Rentschler Field • East Hartford, CT | W 44–13 |
| October 23 | Independent | Liberty | North Texas | Apogee Stadium • Denton, TX | L 26–35 |

### Conference USA vs FCS matchups

| Date | Visitor | Home | Site | Score |
| September 1 | UAB | Jacksonville State | Cramton Bowl • Montgomery, AL | W 31–0 |
| September 2 | LIU | FIU | Riccardo Silva Stadium • Miami, FL | W 48–10 |
| September 2 | UT Martin | Western Kentucky | Houchens Industries–L. T. Smith Stadium • Bowling Green, KY | W 59–21 |
| September 4 | Monmouth | Middle Tennessee | Johnny "Red" Floyd Stadium • Murfreesboro, TN | W 50–15 |
| September 4 | Northwestern State | North Texas | Apogee Stadium • Denton, TX | W 44–14 |
| September 4 | Bethune–Cookman | UTEP | Sun Bowl • El Paso, TX | W 38–28 |
| September 11 | Gardner–Webb | Charlotte | Jerry Richardson Stadium • Charlotte, NC | W 38–10 |
| September 11 | Lamar | UTSA | Alamodome • San Antonio, TX | W 54–0 |
| September 11 | North Carolina Central | Marshall | Joan C. Edwards Stadium • Huntington, WV | W 44–10 |
| September 11 | Southeastern Louisiana | Louisiana Tech | Joe Aillet Stadium • Ruston, LA | W 45–42 |
| September 11 | Hampton | Old Dominion | S.B. Ballard Stadium • Norfolk, VA | W 47–7 |
| September 11 | Grambling State | Southern Miss | M. M. Roberts Stadium • Hattiesburg, MS | W 37–0 |
| September 18 | Fordham | Florida Atlantic | FAU Stadium • Boca Raton, FL | W 45–14 |
| September 25 | Texas Southern | Rice | Rice Stadium • Houston, TX | W 48–34 |

## Awards and honors
### Player of the week honors

| Week | Offensive | Offensive | Offensive | Defensive | Defensive | Defensive | Special Teams | Special Teams | Special Teams |
| Week | Player | Team | Position | Player | Team | Position | Player | Team | Position |
| Week 0 (August 30) | Jacob Cowing | UTEP | WR | Dy'Vonne Inyang | UTEP | S | Gavin Baechle | UTEP | K |
| Week 1 (September 6) | Chris Reynolds | Charlotte | QB | Eli Neal | Marshall | LB | Hunter Duplessis | UTSA | K |
| Week 2 (September 13) | Bailey Zappe N'Kosi Perry | Western Kentucky Florida Atlantic | QB QB | BeeJay Williamson | Louisiana Tech | DB | Sheldon Jones | UTSA | PR |
| Week 3 (September 20) | Gerrit Prince | UAB | TE | Trumane Bell II | UTSA | DL | Kyle Greenwell | UAB | P |
| Week 4 (September 27) | Chris Reynolds (2) | Charlotte | QB | Clarence Hicks A.J. Brathwaite | UTSA Western Kentucky | LB S | Hunter Duplessis (2) | UTSA | K |
| Week 5 (October 4) | Bailey Zappe (2) | Western Kentucky | QB | Reed Blankenship | Middle Tennessee | S | Cameron Harrell | Southern Miss | KR |
| Week 6 (October 11) | Frank Harris | UTSA | QB | Alex Wright | UAB | DE | Shadrick Byrd | Charlotte | KR |
| Week 7 (October 18) | Jerreth Sterns | Western Kentucky | WR | Jadrian Taylor | UTEP | DE | Grayson Cash | UAB | S |
| Week 8 (October 25) | Wiley Green | Rice | QB | Gabe Taylor | Rice | S | Brayden Narveson | Western Kentucky | K |
| Week 9 (November 1) | Bailey Zappe (3) | Western Kentucky | QB | DQ Thomas | Middle Tennessee | LB | Nick Rice | Old Dominion | K |
| Week 10 (November 8) | DeWayne McBride | UAB | RB | Beanie Bishop | Western Kentucky | DB | Jayden Harrison | Marshall | KR |
| Week 11 (November 15) | Bailey Zappe (4) | Western Kentucky | QB | Jason Henderson | Old Dominion | LB | R'Tarriun Johnson | Old Dominion | S |
| Week 12 (November 22) | Frank Harris (2) | UTSA | QB | Clarence Hicks (2) | UTSA | LB | Hunter Duplessis (3) | UTSA | K |
| Week 13 (November 29) | Ali Jennings | Old Dominion | WR | DeAngelo Malone | Western Kentucky | DE | Brayden Narveson (2) | Western Kentucky | K |

### Conference USA Individual Awards

The following individuals received postseason honors as voted by the Conference USA football coaches at the end of the season.
| Award | Player | School |
| Player of the Year | Bailey Zappe, QB, Grad. | Western Kentucky |
| Offensive Player of the Year | Sincere McCormick, RB, So. | UTSA |
| Defensive Player of the Year | DeAngelo Malone, DE, Sr. | Western Kentucky |
| Special Teams Player of the Year | Tommy Heatherly, P, Sr. | FIU |
| Freshman Player of the Year | Elijah Spencer, WR | Charlotte |
| Newcomer of the Year | Jerreth Sterns, WR, Jr. | Western Kentucky |
| Coach of the Year | Jeff Traylor | UTSA |

### All-Conference Teams

The following players were selected as part of the Conference USA's All-Conference Teams.
| Position | Player | Team |
| First Team Offense |||
| WR | Jerreth Sterns | Western Kentucky |
| WR | Jacob Cowing | UTEP |
| WR | Zakhari Franklin | UTSA |
| OL | Alex Mollette | Marshall |
| OL | Cole Spencer | Western Kentucky |
| OL | Spencer Burford | UTSA |
| OL | Colby Ragland | UAB |
| OL | Mason Brooks | Western Kentucky |
| TE | Zack Kuntz | Old Dominion |
| QB | Bailey Zappe | Western Kentucky |
| RB | Sincere McCormick | UTSA |
| RB | Rasheen Ali | Marshall |
| First Team Defense |||
| DE | Praise Amaewhule | UTEP |
| DL | Elijah Garcia | Rice |
| DL | Tyree Turner | UAB |
| DE | DeAngelo Malone | Western Kentucky |
| LB | KD Davis | North Texas |
| LB | Abraham Beauplan | Marshall |
| LB | Clarence Hicks | UTSA |
| DB | Reed Blankenship | Middle Tennessee |
| DB | Rashad Wisdom | UTSA |
| DB | Beanie Bishop | Western Kentucky |
| DB | Quincy Riley | Middle Tennessee |
| First Team Special Teams |||
| K | Hunter Duplessis | UTSA |
| P | Tommy Heatherly | FIU |
| LS | Reeves Blankenship | Louisiana Tech |
| KR | Cameron Harrell | Southern Miss |
| PR | Jaylin Lane | Middle Tennessee |
| Position | Player | Team |
| Second Team Offense |||
| WR | Mitchell Tinsley | Western Kentucky |
| WR | Jason Brownlee | Southern Miss |
| WR | Tyrese Chambers | FIU |
| OL | Will Ulmer | Marshall |
| OL | Quantavious Leslie | Western Kentucky |
| OL | Ahofitu Maka | UTSA |
| OL | Manase Mose | North Texas |
| OL | Boe Wilson | Western Kentucky |
| TE | Gerrit Prince | UAB |
| QB | Frank Harris | UTSA |
| RB | DeWayne McBride | UAB |
| RB | DeAndre Torrey | North Texas |
| Second Team Defense |||
| DE | Jordan Ferguson | Middle Tennessee |
| DL | Dion Novil | North Texas |
| DL | Jaylon Haynes | UTSA |
| DE | Alex Wright | UAB |
| LB | Breon Hayward | UTEP |
| LB | Tyler Grubbs | Louisiana Tech |
| LB | DQ Thomas | Middle Tennessee |
| DB | Steven Gilmore | Marshall |
| DB | Micah Abraham | Marshall |
| DB | Grayson Cash | UAB |
| DB | Richard Dames | FIU |
| Second Team Special Teams |||
| K | Brayden Narveson | Western Kentucky |
| P | Lucas Dean | UTSA |
| LS | Caleb Cantrell | UTSA |
| KR | Jayden Harrison | Marshall |
| PR | Smoke Harris | Louisiana Tech |

### All-Americans

The 2021 College Football All-America Teams are composed of the following College Football All-American first teams chosen by the following selector organizations: Associated Press (AP), Football Writers Association of America (FWAA), American Football Coaches Association (AFCA), Walter Camp Foundation (WCFF), The Sporting News (TSN), Sports Illustrated (SI), USA Today (USAT) ESPN, CBS Sports (CBS), FOX Sports (FOX) College Football News (CFN), Bleacher Report (BR), Scout.com, Phil Steele (PS), SB Nation (SB), Athlon Sports, Pro Football Focus (PFF) and Yahoo! Sports (Yahoo!).
Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources. The system consists of three points for a first-team honor, two points for second-team honor, and one point for third-team honor. Honorable mention and fourth team or lower recognitions are not accorded any points. Football consensus teams are compiled by position and the player accumulating the most points at each position is named first team consensus all-American. Currently, the NCAA recognizes All-Americans selected by the AP, AFCA, FWAA, TSN, and the WCFF to determine Consensus and Unanimous All-Americans. Any player named to the First Team by all five of the NCAA-recognized selectors is deemed a Unanimous All-American.
| Position | Player | School | Selector |
| Second Team All-Americans ||||||
| WR | Jerreth Sterns | Western Kentucky | AP, FWAA, USAT |
| RB | Sincere McCormick | UTSA | CBS, FWAA, USAT |
| Position | Player | School | Selector | Unanimous | Consensus |
| Third Team All-Americans ||||||
| RB | Sincere McCormick | UTSA | AP | | |

## NFL Draft

The following list includes all C-USA players who were drafted in the 2022 NFL draft.
| Player | Position | School | Draft Round | Round Pick | Overall Pick | Team |
| Alex Wright | DE | UAB | 3 | 14 | 78 | Cleveland Browns |
| DeAngelo Malone | LB | Western Kentucky | 3 | 18 | 82 | Atlanta Falcons |
| Spencer Burford | OT | UTSA | 4 | 29 | 134 | San Francisco 49ers |
| Bailey Zappe | QB | Western Kentucky | 4 | 32 | 137 | New England Patriots |
| Tariq Woolen | CB | UTSA | 5 | 10 | 153 | Seattle Seahawks |
| Nazeeh Johnson | S | Marshall | 7 | 38 | 259 | Kansas City Chiefs |