# List of airplay number-one singles of 2021 (Uruguay)

Singles chart Monitor Latino ranks the songs which received the most airplay per week on radio station in Latin America, including Uruguay, since 2017. In 2021, 15 songs managed to top the chart, while "Todo de Ti", by Rauw Alejandro, was the best-performing track of the year.

## Chart history

List of number-one singles :
| Issue date | Song | Artist(s) |
| 4 January | "Malditos Celos" | Ache featuring Anonimus |
| 11 January | "No Me Busques" | Yas Gagliardi |
| 18 January | "Malditos Celos" | Ache featuring Anonimus |
| 25 January | "Malditos Celos" | Ache featuring Anonimus |
| 1 February | "Malditos Celos" | Ache featuring Anonimus |
| 8 February | "Malditos Celos" | Ache featuring Anonimus |
| 15 February | "Malditos Celos" | Ache featuring Anonimus |
| 22 February | "Malditos Celos" | Ache featuring Anonimus |
| 1 March | "Malditos Celos" | Ache featuring Anonimus |
| 8 March | "Ropa Cara" | Camilo |
| 15 March | "Ropa Cara" | Camilo |
| 22 March | "Lo Primero" | Yas Gagliardi |
| 29 March | "Lo Primero" | Yas Gagliardi |
| 5 April | "AM" | Nio García |
| 12 April | "AM" | Nio García |
| 19 April | "AM" | Nio García |
| 26 April | "AM" | Nio García |
| 3 May | "AM" | Nio García |
| 10 May | "Miénteme" | Tini featuring María Becerra |
| 17 May | "Miénteme" | Tini featuring María Becerra |
| 24 May | "Miénteme" | Tini featuring María Becerra |
| 31 May | "Miénteme" | Tini featuring María Becerra |
| 7 June | "Miénteme" | Tini featuring María Becerra |
| 14 June | "Todo de Ti" | Rauw Alejandro |
| 21 June | "Pikete" | Nicky Jam featuring El Alfa |
| 28 June | "Dancefreak" | Domino Saints |
| 5 July | "Dancefreak" | Domino Saints |
| 12 July | "Todo de Ti" | Rauw Alejandro |
| 19 July | "Todo de Ti" | Rauw Alejandro |
| 26 July | "Todo de Ti" | Rauw Alejandro |
| 2 August | "Dancefreak" | Domino Saints |
| 9 August | "Todo de Ti" | Rauw Alejandro |
| 16 August | "Tus Poses" | Nio García |
| 23 August | "Tus Poses" | Nio García |
| 30 August | "Sobrio" | Maluma |
| 6 September | "Sobrio" | Maluma |
| 13 September | "Hielo" | Juan Y Rafa featuring Daneon |
| 20 September | "Darte" | Casper Magico featuring Nio García and Zion & Lennox |
| 27 September | "Darte" | Casper Magico featuring Nio García and Zion & Lennox |
| 4 October | "Sobrio" | Maluma |
| 11 October | "Sobrio" | Maluma |
| 18 October | "Impostora" | Vi Em |
| 25 October | "Sobrio" | Maluma |
| 1 November | "Sobrio" | Maluma |
| 8 November | "Hielo" | Juan Y Rafa featuring Daneon |
| 15 November | "Hielo" | Juan Y Rafa featuring Daneon |
| 22 November | "Impostora" | Vi Em |
| 29 November | "Impostora" | Vi Em |
| 6 December | "Tacones Rojos" (remix) | Sebastián Yatra featuring John Legend |
| 13 December | "Tacones Rojos" (remix) | Sebastián Yatra featuring John Legend |
| 20 December | "Tacones Rojos" (remix) | Sebastián Yatra featuring John Legend |
| 27 December | "Tacones Rojos" (remix) | Sebastián Yatra featuring John Legend |

## Number-one artists

List of number-one artists, with total weeks spent at number one shown :
| Position | Artist | Weeks at No. 1 |
| 1 | Nio García | 9 |
| 2 | Ache | 8 |
| 2 | Anonimus | 8 |
| 3 | Maluma | 6 |
| 4 | Tini | 5 |
| 4 | María Becerra | 5 |
| 4 | Rauw Alejandro | 5 |
| 5 | Sebastián Yatra | 4 |
| 5 | John Legend | 4 |
| 6 | Yas Glagiardi | 3 |
| 6 | Domino Saints | 3 |
| 6 | Juan Y Rafa | 3 |
| 6 | Daneon | 3 |
| 6 | Vi Em | 3 |
| 7 | Camilo | 2 |
| 7 | Casper Magico | 2 |
| 7 | Zion & Lennox | 2 |
| 8 | Nicky Jam | 1 |
| 8 | El Alfa | 1 |