# List of investigational analgesics

This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
This list was last comprehensively updated in June 2017. It is likely to become outdated with time.

## Opioid receptor modulators

* Axelopran/oxycodone – combination of a centrally active μ-opioid receptor agonist and a peripherally selective μ-, κ-, and δ-opioid receptor antagonist.
* Cebranopadol (GRT-6005) – non-selective μ-opioid receptor, nociceptin receptor, and δ-opioid receptor full agonist and κ-opioid receptor partial agonist
* Desmetramadol (O-desmethyltramadol; Omnitram) – μ-opioid receptor agonist, norepinephrine reuptake inhibitor (NRI), and 5-HT$_{2C}$ receptor antagonist.
* Deumitragynine (KUR-101) – atypical μ-opioid receptor agonist related to mitragynine (found in kratom)
* Lexanopadol [Wikidata] (GRT-6006, GRT13106G) – non-selective opioid receptor agonist
* Oxycodone/naltrexone – combination of a μ-opioid receptor agonist and a μ- and κ-opioid receptor antagonist.

## Sodium channel blockers

* BIIB-095 – state-dependent and use-dependent Na$_v$ blocker, including Na$_v$1.7.
* CC-8464 (ASP-1807) – selective Na$_v$1.7 blocker
* Cenobamate (YKP-3089) – atypical voltage-gated sodium channel blocker.$^{:5593–5605}$
* DSP-2230 – selective Na$_v$1.7 and Na$_v$1.8 blocker.
* Funapide (TV-45070, XEN402) – selective Na$_v$1.7 and Na$_v$1.8 blocker.
* GDC-0276 (RG-7893) – selective Na$_v$1.7 blocker
* GDC-0310 (RG-6029) – selective Na$_v$1.7 blocker
* NKTR-171 – voltage-gated sodium channel blocker
* PF-05089771 – selective Na$_v$1.7 and Na$_v$1.8 blocker
* Ralfinamide (NW-1029) – non-selective voltage-gated sodium channel blocker, as well as other actions
* Tetrodotoxin (9401-TTX; Tectin, Tetrodin, Tocudin) – non-selective voltage-gated sodium channel blocker
* Vixotrigine (formerly raxatrigine; CNV1014802, GSK-1014802, BIIB 074) – non-selective voltage-gated sodium channel blocker
* VX-150 – selective Na$_v$1.8 blocker

## Calcium channel blockers

* HSK16149 – selective ligand of α$_2$δ subunit of voltage-gated calcium channel

## TRP channel modulators

* Capsaicin (Adlea, ALGRX-4975, CNTX-4975, VLNX-4975) – TRPV1 agonist
* Capsaicin/diclofenac – combination of a TRPV1 agonist and a COX-2 inhibitor for topical application
* CMX-020 – TRPV1 modulator as well as CB$_1$ and CB$_2$ receptor modulator
* DWP-05195 (TR-1) – TRPV1 antagonist
* GRC-6211 – TRPV1 agonist
* JNJ-38893777 – TRPV1 antagonist
* Mavatrep (JNJ‐39439335) – TRPV1 antagonist.$^{:712–726}$
* NEO-6860 – TRPV1 antagonist
* Parentide (DD-04107) – TRPV1 antagonist
* Resiniferatoxin (RTX; MCP-101) – TRPV1 agonist
* SAR-115740 – TRPV1 antagonist
* Tivanisiran (SYL-1001) – TRPV1 antagonist

## Cannabinoid receptor modulators

* ABX-1431 – selective monoacylglycerol lipase inhibitor
* Cannabidiol (CBD) – cannabinoid receptor modulator
* Cannabidivarin (CBDV; GWP-42006) – cannabinoid receptor modulator
* CMX-020 – TRPV1 modulator as well as CB$_1$ and CB$_2$ receptor modulator
* Dronabinol (Δ$^9$-THC; ECP022A, Namisol) – CB$_1$ and CB$_2$ receptor agonist
* Nabilone – CB$_1$ and CB$_2$ receptor agonist
* NEO-1940 – CB$_1$ and CB$_2$ receptor agonist
* Olorinab (APD-371) – CB$_2$ receptor agonist

## Nerve growth factor inhibitors

* Fasinumab (REGN-475, SAR-164877) – monoclonal antibody against nerve growth factor
* Fulranumab (AMG-403, JNJ-42160443) – monoclonal antibody against nerve growth factor
* GBR-900 – monoclonal antibody against TrkA
* GZ-389988 – TrkA, TrkB, and TrkC kinase inhibitor
* LEVI-04 (p75$^{NTR}$-Fc) – LNGF receptor (p75$^{NTR}$) fusion protein and decoy receptor for nerve growth factor
* NRD135S-E1 – tyrosine kinase modulator
* ONO-4474 – peripherally selective TrkA, TrkB, and TrkC kinase inhibitor
* Ranevetmab (NV-01) – monoclonal antibody against nerve growth factor for dogs
* Tanezumab (PF-4383119, RI-624, RN-624) – monoclonal antibody against nerve growth factor
* VM-902A – selective, peripherally selective allosteric inhibitor of TrkA

## Others

* ALLOD-2 – undefined mechanism of action
* CR-4056 – imidazoline I$_2$ receptor agonist
* E-52862 (MR-309; S1A; S1RA) – sigma-1 receptor antagonist
* HSP-3150 – undefined mechanism of action
* KCP-506 – nicotinic acetylcholine receptor antagonist
* LATER – CRISPR-dCas9 gene-editing
* PAX-01 – undefined mechanism of action
* Opiranserin - Dual 5HT2A Receptor antagonist and GlyT2 inhibitor