# 2022 United States Senate election in Missouri

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The 2022 United States Senate election in Missouri was held on November 8, 2022, concurrently with elections for all other Class 3 U.S. senators and elections for the U.S. House of Representatives, to select a member of the United States Senate to represent the state of Missouri. Incumbent senator Roy Blunt, a Republican, did not seek a third term in office. Republican Missouri Attorney General Eric Schmitt won the open seat, defeating Democrat Trudy Busch Valentine.

## Republican primary

In March 2021, incumbent Republican Senator Roy Blunt announced that he would not seek reelection in 2022.
Republican candidates for Blunt's Senate seat included former Gov. Eric Greitens, U.S. Rep. Vicky Hartzler, U.S. Rep. Billy Long, and Missouri Attorney General Eric Schmitt.
Schmitt's candidacy was backed by Missouri mega-donor Rex Sinquefield. In the speech announcing his candidacy, Schmitt tied himself to Donald Trump and spoke against "the radical left". He pledged to vote against Mitch McConnell for the Senate Republican party leadership position.
In February 2022, Hartzler's campaign released a 30-second ad criticizing Lia Thomas, a transgender swimmer on the University of Pennsylvania women's team. In the ad, Hartzler said, "Women's sports are for women, not men pretending to be women", adding that, as Missouri's senator, she would not "look away while woke liberals destroy women's sports."
U.S. Sen. Josh Hawley endorsed Hartzler in February 2022. On July 8, 2022, Donald Trump refused to endorse Hartzler, saying, "I don't think she has what it takes to take on the Radical Left Democrats."
Greitens was endorsed by former New York City mayor Rudy Giuliani, former U.S. Secretary of the Interior Ryan Zinke, and Fox News personality Kimberly Guilfoyle, the latter joining his campaign as a national chair.
Many Republican officials, strategists, and donors maneuvered to stymie Greitens's attempted comeback, believing that the scandal surrounding his resignation as governor, his extramarital affair, and the sexual assault accusation against him would make him a weak general election candidate and lead to the loss of the Senate seat to a Democrat. Notable Republican opponents of Greitens's candidacy included Karl Rove, Johnny DeStefano, and Senator Rick Scott, the chairman of the National Republican Senatorial Committee. After Greitens's ex-wife filed an affidavit against him in March 2022 accusing him of physical abuse, Senator Josh Hawley (who had endorsed Vicky Hartzler the previous month) called upon Greitens to drop out.
Republican megadonor Richard Uihlein funded a pro-Greitens super PAC ("Team PAC"), contributing $2.5 million to it. Other Republican megadonors, including Rex Sinquefield and August Busch, aligned against Greitens. A Republican-funded anti-Greitens super PAC ("Show Me Values PAC") was created in June 2022 and ran $6.2 million in ads through late July 2022.
Republican officials, including Rick Scott, waged a campaign to persuade Donald Trump not to endorse Greitens. On the eve of the primary election, Trump issued a statement endorsing "ERIC" in the primary, leaving it unclear which "Eric" he was endorsing.
In the primary election, Schmitt prevailed with 45.7% of the vote; Hartzler received 22.1%, Greitens 18.9%, and Long 5%.

### Candidates
#### Nominee

* Eric Schmitt, Missouri Attorney General (2019–2023) and former Missouri State Treasurer (2017–2019)

#### Eliminated in primary

* Robert Allen
* Russel Pealer Breyfogle Jr., retired social worker
* Dennis Lee Chilton, 2018 Missouri House of Representatives candidate
* C. W. Gardner, doorman and former broadcaster
* Eric Greitens, former governor of Missouri (2017–2018)
* Vicky Hartzler, U.S. Representative from Missouri's 4th congressional district (2011–2023)
* Rickey Joiner, barber and business owner
* Patrick A. Lewis, union construction laborer
* Billy Long, U.S. Representative from Missouri's 7th congressional district (2011–2023)
* Darrell Leon McClanahan III, political activist, KKK Member
* Mark McCloskey, attorney and 2020 Republican National Convention speaker known for his involvement in the St. Louis gun-toting controversy
* Eric McElroy, comedian and U.S. Navy veteran
* Bernie Mowinsk, retired U.S. Air Force sergeant and perennial candidate
* Robert Olson
* Deshon Porter, host of The Big D Zone
* Dave Schatz, president pro tempore of the Missouri Senate (2019–2023), state senator (2015–2023)
* Kevin C. Schepers
* Dave Sims, Monett public works employee and former radio host
* Hartford Tunnell, college professor
* Curtis D. Vaughn, valet parking attendant and liquor salesman

#### Missed filing deadline

* John Brinkmann, insurance agency owner and financial consultant
* Rik Combs, retired U.S. Air Force Officer and Libertarian nominee for Governor of Missouri in 2020
* Jeremy Gundel, farmer and write-in candidate for Lieutenant Governor of Missouri in 2020

#### Withdrew

* Roy Blunt, incumbent U.S. Senator (2011–2023) and Chair of the Senate Republican Policy Committee (2019–2023)
* Dan McQueen, former mayor of Corpus Christi, Texas (2016–2017) (ran for the U.S. House)

#### Declined

* Jay Ashcroft, Missouri Secretary of State (2017–present)
* Scott Fitzpatrick, Missouri State Treasurer (2019–2023) (ran for state auditor)
* Timothy A. Garrison, former U.S. Attorney for the Western District of Missouri (2018–2021)
* Mike Kehoe, Lieutenant Governor of Missouri (2018–present) (ran for governor)
* Peter Kinder, former lieutenant governor of Missouri (2005–2017)
* Blaine Luetkemeyer, U.S. Representative from Missouri's 3rd congressional district (2013–present) and Missouri's 9th congressional district (2009–2013) (ran for re-election)
* Mike Parson, Governor of Missouri (2018–present)
* Jason Smith, U.S. Representative from Missouri's 8th congressional district (2013–present) (ran for re-election)
* Kathy Swan, former state representative (2012–2021)
* Ann Wagner, U.S. Representative from Missouri's 2nd congressional district (2013–present) (ran for re-election)

### Endorsements

The day before the primary, former president Donald Trump released a statement endorsing "ERIC". There were three candidates with the first name Eric running in the Republican primary: Eric Greitens, Eric McElroy, and Eric Schmitt. Trump's statement did not offer any clarification on whether this was an endorsement for one or multiple candidates, and when reached for comment by NBC News, Trump's office declined to clarify the endorsement.
Federal officials
* Joseph diGenova, U.S. Attorney for the District of Columbia (1983–1988), attorney to President Donald Trump
* Michael Flynn, U.S. National Security Advisor (2017) (Democratic)
* Sebastian Gorka, Deputy Assistant to the President (2017)
* Ryan Zinke, U.S. Secretary of the Interior (2017–2019) and U.S. Representative from Montana's at-large congressional district (2015–2017)
Individuals
* Rudy Giuliani, Mayor of New York City (1994–2001)
* Kimberly Guilfoyle, television news personality
* Bernard Marcus, billionaire and co-founder of The Home Depot
* Victoria Toensing, attorney to President Donald Trump
* Richard Uihlein, billionaire and co-founder of Uline
Organizations
* New York Young Republican Club
Federal officials
* Michele Bachmann, U.S. Representative for Minnesota's 6th congressional district (2007–2015) and candidate for president in 2012
* Kit Bond, U.S. Senator from Missouri (1987–2011)
* Deb Fischer, U.S. Senator from Nebraska (2013–present)
* Josh Hawley, U.S. Senator from Missouri (2019–present)
* Roger Marshall, U.S. Senator from Kansas (2021–present)
* Tony Perkins, President of the Family Research Council (2003–present), Chair of the United States Commission on International Religious Freedom (2019–2020), and Louisiana state representative (1996–2004)
Individuals
* Eric Metaxas, Christian author and conservative radio host
* Penny Nance, president of Concerned Women for America
Organizations
* Maggie's List
* Missouri Cattlemen's Association
* Missouri Farm Bureau
* Susan B. Anthony List
Federal officials
* Ted Cruz, U.S. Senator from Texas (2013–present) and candidate for president in 2016
* Mike Lee, U.S. Senator from Utah (2011–present)
* Robert C. O'Brien, U.S. National Security Advisor (2019–2021) and Special Envoy for Hostage Affairs (2019–2019)
* Sarah Huckabee Sanders, White House Press Secretary (2017–2019) and nominee for Governor of Arkansas in 2022
* Matthew Whitaker, acting U.S. Attorney General (2018–2019), U.S. Attorney for the Southern District of Iowa (2004–2009), nominee for Iowa State Treasurer in 2002, and candidate for U.S. Senate in 2014
State officials
* Winsome Sears, Lieutenant Governor of Virginia (2022–present)
State legislators
* Cyndi Buchheit-Courtway, state representative for Missouri's 115th district (2021–present)
* Cindy O'Laughlin, state senator for Missouri's 18th district (2018–present)
Individuals
* Dana Loesch, radio and TV host
* Rex Sinquefield, philanthropist and President of the Show-Me Institute
Organizations
* Americans for Prosperity Action
* Gun Owners of America
* Missouri Fraternal Order of Police
* Senate Conservatives Fund
* Tea Party Express

### Debates

| Date | Host | Moderator | Link(s) | Participants | Participants | Participants | Participants | Participants | Participants |
| Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | | | | | | |
| Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Key: P Participant  A Absent  N Non-invitee  I Invitee W Withdrawn | Eric Greitens | Vicky Hartzler | Billy Long | Mark McCloskey | Dave Schatz | Eric Schmitt |
| May 31, 2022 | Greene County Republicans | Ginger Gooch Darrell Moore | | A | A | P | P | P | A |

### Polling

Graphical summary
| Source of poll aggregation | Dates administered | Dates updated | Eric Greitens | Vicky Hartzler | Billy Long | Mark McCloskey | Dave Schatz | Eric Schmitt | Other | Margin |
| Real Clear Politics | July 21 – 24, 2022 | July 26, 2022 | 19.0% | 24.5% | 7.0% | 5.0% | 2.5% | 33.0% | 9.0% | Schmitt +8.5 |
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens | Vicky Hartzler | Billy Long | Mark McCloskey | Dave Schatz | Eric Schmitt | Other | Undecided |
| The Trafalgar Group (R) | July 31 – August 1, 2022 | 1,078 (LV) | ± 2.9% | 21% | 18% | 5% | 5% | 3% | 34% | – | 15% |
| Remington Research (R)/Missouri Scout | July 27–28, 2022 | 818 (LV) | ± 3.4% | 18% | 22% | 6% | 5% | 5% | 34% | 2% | 8% |
| co/efficient (R) | July 27, 2022 | 891 (LV) | ± 3.3% | 17% | 16% | – | – | – | 28% | – | – |
| SurveyUSA | July 24–27, 2022 | 787 (LV) | ± 4.2% | 20% | 13% | 8% | 4% | 3% | 28% | 4% | 21% |
| Emerson College | July 21–23, 2022 | 1,000 (LV) | ± 3.0% | 16% | 21% | 5% | 4% | 2% | 33% | 1% | 17% |
| Remington Research (R)/Missouri Scout | July 23–24, 2022 | 802 (LV) | ± 3.4% | 18% | 25% | 8% | 4% | 3% | 32% | – | 10% |
| The Trafalgar Group (R) | July 22–24, 2022 | 1,059 (LV) | ± 2.9% | 20% | 24% | 7% | 5% | 2% | 27% | – | 16% |
| The Tarrance Group (R) | July 5–7, 2022 | 600 (LV) | ± 4.0% | 16% | 24% | 6% | 4% | 4% | 28% | – | 18% |
| The Trafalgar Group (R) | June 28–30, 2022 | 1,072 (LV) | ± 2.9% | 24% | 24% | 6% | 3% | 4% | 23% | – | 17% |
| Remington Research (R)/Missouri Scout | June 22–23, 2022 | 911 (LV) | ± 3.1% | 20% | 19% | 8% | 5% | 2% | 25% | – | 21% |
| Emerson College | June 2–5, 2022 | 1,000 (LV) | ± 3.0% | 26% | 16% | 8% | 4% | 0% | 20% | 1% | 27% |
| The Trafalgar Group (R) | May 16–18, 2022 | 1,065 (LV) | ± 2.9% | 26% | 23% | 9% | 3% | 3% | 19% | – | 17% |
| SurveyUSA | May 11–15, 2022 | 642 (LV) | ± 5.0% | 26% | 11% | 7% | 2% | 2% | 17% | 7% | 28% |
| Remington Research (R) | May 11–12, 2022 | 945 (LV) | ± 3.0% | 21% | 23% | – | – | – | 29% | 10% | 17% |
| co/efficient (R) | May 2–4, 2022 | 806 (LV) | ± 3.5% | 26% | 19% | 7% | 5% | 2% | 14% | – | 27% |
| NMB Research (R) | April 6–7, 2022 | 500 (LV) | ± 4.4% | 23% | 20% | 7% | 3% | 2% | 25% | 20% | – |
| OnMessage Inc. (R) | April 4–6, 2022 | 600 (LV) | ± 4.0% | 22% | 23% | 11% | 5% | 2% | 16% | – | 21% |
| The Trafalgar Group (R) | March 24–29, 2022 | 1,079 (LV) | ± 3.0% | 24% | 25% | 8% | 2% | 3% | 22% | – | 16% |
| Remington Research (R)/Missouri Scout | March 22–23, 2022 | 941 (LV) | ± 3.1% | 21% | 19% | 9% | 5% | 3% | 24% | – | 19% |
| The Trafalgar Group (R) | February 22–24, 2022 | 1,026 (LV) | ± 3.0% | 31% | 17% | 6% | 5% | 2% | 23% | 3% | 15% |
| Remington Research (R)/Missouri Scout | February 16–17, 2022 | 917 (LV) | ± 3.1% | 25% | 18% | 8% | 5% | 2% | 22% | – | 20% |
| Remington Research (R)/Missouri Scout | January 26–27, 2022 | 902 (LV) | ± 3.1% | 28% | 19% | 7% | 5% | 1% | 23% | – | 17% |
| OnMessage Inc. (R) | January 2022 | – (LV) | – | 30% | 16% | 9% | 6% | 1% | 16% | – | 23% |
| CMA Strategies (R) | January 2022 | 400 (LV) | ± 5.0% | 27% | 12% | 6% | 4% | 1% | 15% | – | 36% |
| Remington Research (R)/Missouri Scout | December 1–2, 2021 | 744 (LV) | ± 3.4% | 27% | 16% | 7% | 4% | 3% | 24% | – | 19% |
| NMB Research (R) | December 2021 | – (LV) | – | 34% | – | – | – | – | 17% | 49% | – |
| Remington Research (R)/Missouri Scout | October 20–21, 2021 | 806 (LV) | ± 3.2% | 27% | 19% | 8% | 4% | – | 25% | – | 17% |
| Fabrizio Lee (R) | October 3–5, 2021 | 400 (LV) | ± 4.9% | 36% | 10% | 6% | 4% | – | 17% | 1% | 25% |
| Remington Research (R)/Missouri Scout | September 8–9, 2021 | 847 (LV) | ± 3.2% | 27% | 17% | 8% | 5% | – | 28% | – | 15% |
| Remington Research (R)/Missouri Scout | August 4–5, 2021 | 911 (LV) | ± 3.0% | 27% | 13% | 12% | 9% | – | 24% | – | 15% |
| Remington Research (R)/Missouri Scout | June 9–10, 2021 | 1,011 (LV) | ± 3.0% | 34% | 14% | – | 7% | – | 25% | – | 20% |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | 36% | – | 14% | – | – | 30% | – | 20% |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | 40% | – | – | – | – | 39% | – | 21% |
| Poll source | Date(s) administered | Sample size | Margin of error | Roy Blunt | John Brunner | Eric Greitens | Vicky Hartzler | Billy Long | Eric Schmitt | Jason Smith | Ann Wagner | Undecided |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | – | 2% | 31% | 8% | 6% | 18% | 9% | 12% | 14% |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | – | 10% | 38% | – | – | 30% | – | – | 22% |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | – | – | 36% | – | – | 29% | 16% | – | 19% |
| Remington Research (R)/Missouri Scout | March 24–25, 2021 | 1,041 (LV) | ± 3.0% | – | – | 38% | – | – | 26% | – | 18% | 18% |
| Fabrizio, Lee & Associates (R) | March 23–25, 2021 | 400 (LV) | ± 4.9% | – | – | 48% | – | – | 11% | 7% | 9% | 26% |
| Remington Research (R)/Missouri Scout | December 2–3, 2020 | 840 (LV) | ± 3.4% | 43% | – | 32% | – | – | – | – | – | 25% |

### Results

Republican primary results :
| Party | Party | Candidate | Votes | % |
| | Republican | Eric Schmitt | 299,282 | 45.6 |
| | Republican | Vicky Hartzler | 144,903 | 22.1 |
| | Republican | Eric Greitens | 124,155 | 18.9 |
| | Republican | Billy Long | 32,603 | 5.0 |
| | Republican | Mark McCloskey | 19,540 | 3.0 |
| | Republican | Dave Schatz | 7,509 | 1.1 |
| | Republican | Patrick A. Lewis | 6,085 | 0.9 |
| | Republican | Curtis D. Vaughn | 3,451 | 0.5 |
| | Republican | Eric McElroy | 2,805 | 0.4 |
| | Republican | Robert Allen | 2,111 | 0.3 |
| | Republican | C. W. Gardner | 2,044 | 0.3 |
| | Republican | Dave Sims | 1,949 | 0.3 |
| | Republican | Bernie Mowinski | 1,602 | 0.2 |
| | Republican | Deshon Porter | 1,574 | 0.2 |
| | Republican | Darrell Leon McClanahan III | 1,139 | 0.2 |
| | Republican | Rickey Joiner | 1,084 | 0.2 |
| | Republican | Robert Olson | 1,081 | 0.2 |
| | Republican | Dennis Lee Chilton | 755 | 0.1 |
| | Republican | Russel Pealer Breyfogle Jr. | 685 | 0.1 |
| | Republican | Kevin C. Schepers | 681 | 0.1 |
| | Republican | Hartford Tunnell | 637 | 0.1 |
| Total votes | Total votes | Total votes | 655,675 | 100.0 |

## Democratic primary

As the Democratic primary season progressed, three main contenders emerged: Lucas Kunce, director of national security at the American Economic Liberties Project; Spencer Toder, a businessman; and Trudy Busch Valentine, heiress of the Anheuser-Busch brewing company. Kunce and Toder both campaigned as anti-establishment populists, whereas Valentine campaigned in a staid manner with few public appearances.

### Candidates
#### Nominee

* Trudy Busch Valentine, retired nurse, businesswoman, activist, and daughter of beer magnate August Busch Jr.

#### Eliminated in primary

* Ron Harris, truck driver, U.S. Air Force veteran, and perennial candidate
* Jewel Kelly, real estate agent and U.S. Air Force veteran
* Pat Kelly, environmental engineer and patent attorney
* Lucas Kunce, national security director of the American Economic Liberties Project and retired U.S. Marine Corps officer
* Lewis Rolen, medical operational assistant
* Gena Ross, college professor and nominee for Missouri's 6th congressional district in 2020
* Josh Shipp, physical therapy technician and candidate for Missouri's 1st congressional district in 2018
* Clay Taylor
* Spencer Toder, entrepreneur
* Carla Coffee Wright, businesswoman, actress, and perennial candidate

#### Withdrew

* Tim Shepard, tech entrepreneur (endorsed Valentine)
* Scott Sifton, former state senator (2013–2021) (endorsed Valentine)

#### Declined

* Nicole Galloway, incumbent State Auditor of Missouri and nominee for Governor of Missouri in 2020
* Jason Kander, former Secretary of State of Missouri (2013–17) and nominee for U.S. Senate in 2016
* Quinton Lucas, mayor of Kansas City (2019–present) (ran for re-election in 2023)
* Claire McCaskill, former U.S. Senator
* Jay Nixon, former governor of Missouri (2009–2017) and nominee for U.S. Senate in 1988 and 1998
* Brian Williams, state senator (2019–present) (ran for re-election)
* Clint Zweifel, former Missouri State Treasurer (2009–2017)

### Endorsements

U.S. Senators
* Bernie Sanders, U.S. Senator from Vermont (2007–present) and U.S. Representative for Vermont's at-large congressional district (1991–2007)
U.S. Representatives
* Bill Clay, U.S. Representative from Missouri's 1st congressional district (1969–2001)
State officials
* John Fetterman, Lieutenant Governor of Pennsylvania (2019–2023), mayor of Braddock (2006–2019), and Democratic nominee for U.S. Senate in Pennsylvania
State legislators
* Rasheen Aldridge Jr., state representative for Missouri's 78th district (2019–2023)
* Michael Johnson, state representative for Missouri's 23rd district (2021–present)
* Wes Shoemyer, state senator for Missouri's 18th district (2007–2011) and state representative for Missouri's 9th district (2001–2007)
Local officials
* Rita Heard Days, member of the St. Louis County Council (2019–present) and state senator (2003–2011)
* Ella Jones, mayor of Ferguson (2020–present)
* Tommie Pierson Sr., mayor of Bellefontaine Neighbors (2019–present) and state representative for Missouri's 66th district (2011–2017)
* Katheryn Shields, member of the Kansas City, Missouri City Council (2015–present) and County Executive of Jackson County (1995–2007)
Individuals
* Jon Hamm, actor
* Stephanie Taylor, political activist, author, and co-founder of the Progressive Change Campaign Committee
Organizations
* Indivisible St. Louis
* League of Conservation Voters
* MoveOn
* Progressive Change Campaign Committee
* VoteVets
Newspapers and publications
* St. Louis Post-Dispatch
U.S. Senators
* Jean Carnahan, U.S. Senator from Missouri (2001–2002) and First Lady of Missouri (1993–2000)
U.S. Representatives
* Emanuel Cleaver, U.S. Representative from Missouri's 5th congressional district (2005–present) and mayor of Kansas City (1991–1999)
* Dick Gephardt, U.S. Representative from Missouri's 3rd congressional district (1977–2005), House Minority Leader (1995–2003) and House Majority Leader (1989–1995)
State officials
* Bob Holden, Governor of Missouri (2001–2005)
State legislators
* Marlon Anderson, state representative for Missouri's 76th district (2021–present)
* Lauren Arthur, state senator for Missouri's 17th district (2018–present) and state representative for Missouri's 18th district (2015–2018)
* Ashley Aune, state representative for Missouri's 14th district (2021–present)
* Donna Baringer, state representative for Missouri's 82nd district (2017–present)
* Doug Beck, state senator for Missouri's 1st district (2021–present) and state representative for Missouri's 92nd district (2017–2021)
* Steve Butz, state representative for Missouri's 81st district (2019–present)
* Keri Ingle, state representative for Missouri's 35th district (2019–present)
* Ian Mackey, state representative for Missouri's 99th district (2023–present) and 87th district (2019–2023)
* Tracy McCreery, state senator for Missouri's 24th district and state representative for Missouri's 88th district (2015–2023) and 83rd district (2012–2013)
* Wes Rogers, state representative for Missouri's 18th district (2019–present)
* Jill Schupp, state senator for Missouri's 24th district (2015–2023) and nominee for Missouri's 2nd congressional district in 2020
* Scott Sifton, state senator for Missouri's 1st district (2013–2021) and state representative for Missouri's 96th district (2011–2013)
Local officials
* Charlie Dooley, St. Louis County Executive (2003–2015)
* Tishaura Jones, mayor of St. Louis (2021–present)
* Lyda Krewson, mayor of St. Louis (2017–2021)
* Francis Slay, mayor of St. Louis (2001–2017)

### Polling

Graphical summary
| Poll source | Date(s) administered | Sample size | Margin of error | Lucas Kunce | Spencer Toder | Trudy Busch Valentine | Carla "Coffee" Wright | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 547 (LV) | ± 5.6% | 14% | 3% | 40% | 6% | 9% | 28% |
| Emerson College | July 21–23, 2022 | 1,000 (LV) | ± 3.0% | 35% | 3% | 39% | 1% | 1% | 22% |
| Triton Polling & Research (D) | May 2022 | ~544 (LV) | ± 4.2% | 19% | 24% | 26% | – | – | 31% |
| SurveyUSA | May 11–15, 2022 | 500 (LV) | ± 5.0% | 10% | 3% | 8% | 3% | 12% | 63% |
| Public Policy Polling (D) | April 13–14, 2022 | 546 (LV) | ± 4.2% | 25% | – | 18% | – | – | 56% |

### Results

Democratic primary results :
| Party | Party | Candidate | Votes | % |
| | Democratic | Trudy Busch Valentine | 158,957 | 43.2 |
| | Democratic | Lucas Kunce | 141,203 | 38.3 |
| | Democratic | Spencer Toder | 17,465 | 4.7 |
| | Democratic | Carla Coffee Wright | 14,438 | 3.9 |
| | Democratic | Gena Ross | 8,749 | 2.4 |
| | Democratic | Jewel Kelly | 6,464 | 1.8 |
| | Democratic | Lewis Rolen | 5,247 | 1.4 |
| | Democratic | Pat Kelly | 5,002 | 1.4 |
| | Democratic | Ronald (Ron) William Harris | 4,074 | 1.1 |
| | Democratic | Josh Shipp | 3,334 | 0.9 |
| | Democratic | Clarence (Clay) Taylor | 3,322 | 0.9 |
| Total votes | Total votes | Total votes | 368,255 | 100.0 |

## Libertarian primary
### Candidates
#### Nominee

* Jonathan Dine, nominee for U.S. Senate in 2012 and 2016

### Results

Libertarian primary results :
| Party | Party | Candidate | Votes | % |
| | Libertarian | Jonathan Dine | 2,973 | 100.0 |
| Total votes | Total votes | Total votes | 2,973 | 100.0 |

## Constitution primary
### Candidates
#### Nominee

* Paul Venable, information technology consultant and nominee for Secretary of State in 2020

### Results

Constitution primary results :
| Party | Party | Candidate | Votes | % |
| | Constitution | Paul Venable | 792 | 100.0 |
| Total votes | Total votes | Total votes | 792 | 100.0 |

## Independents
### Candidates

John Wood, a former Bush administration official and a January 6 Committee investigator, announced that he would run for the seat as an independent on June 29, but he withdrew from the race after former Missouri Governor Eric Greitens lost the Republican primary to Schmitt.

#### Withdrew

* Thomas Schneider, former mayor of Florissant (2011–2019) (endorsed Schatz and Valentine)
* John Wood, former senior counsel for the United States House Select Committee on the January 6 Attack and former U.S. Attorney for the Western District of Missouri (2007–2009) and former General Counsel for the US Chamber of Commerce

#### Missed ballot deadline

* Rick Seabaugh, sales manager
* Nicholas Strauss, network engineer

## General election
### Predictions

| Source | Ranking | As of |
| 538 | Solid R | November 7, 2022 |
| The Cook Political Report | Solid R | November 7, 2022 |
| DDHQ | Solid R | November 7, 2022 |
| The Economist | Safe R | November 7, 2022 |
| Fox News | Solid R | November 1, 2022 |
| Inside Elections | Solid R | November 3, 2022 |
| Politico | Likely R | August 12, 2022 |
| RCP | Likely R | November 5, 2022 |
| Sabato's Crystal Ball | Safe R | November 7, 2022 |

### Debates

2022 United States Senate general election in Missouri debates :
| No. | Date | Host | Moderator | Republican | Democratic | Libertarian | Constitution |
| P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | | | | |
| P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | P Participant A Absent N Non-invitee I Invitee  W Withdrawn | Eric Schmitt | Trudy Busch Valentine | Jonathan Dine | Paul Venable |
| 1 | September 16, 2022 | Missouri Press Association | David Lieb | A | P | P | P |

### Post-primary endorsements

Federal officials
* John Ashcroft, U.S. Attorney General (2001–2005), U.S. Senator from Missouri (1995–2001) and former governor of Missouri (1985–1993)
* Kit Bond, U.S. Senator from Missouri (1987–2011) and former Governor of Missouri (1981–1985;1973–1977)
* Roy Blunt, U.S. Senator from Missouri (2011–2023)
* Vicky Hartzler, U.S. representative for Missouri's 4th congressional district (2011–2023)
* Josh Hawley, U.S. Senator from Missouri (2019–present)
* Jim Talent, U.S. Senator from Missouri (2002–2007) and U.S. Representative for Missouri's 2nd congressional district (1993–2001)
* Donald Trump, 45th president of the United States (2017–2021)
State officials
* Jay Ashcroft, Secretary of State of Missouri (2017–present)
* Scott Fitzpatrick, Treasurer of Missouri (2018–2023)
* Mike Kehoe, Lieutenant Governor of Missouri (2018–present)
* Mike Parson, Governor of Missouri (2018–present)
Newspapers
* The Missouri Times
Organizations
* FreedomWorks For America
* Missouri Farm Bureau
* National Federation of Independent Business – Missouri
* National Right to Life Committee
* National Rifle Association - Political Victory Fund
Organizations
* Human Rights Campaign
* National Education Association
* National Women's Political Caucus
* Sierra Club
Newspapers
* The Kansas City Star
Federal officials
* John Danforth, United States Ambassador to the United Nations (2004–2005) and U.S. Senator from Missouri (1976–1995) (Republican)

### Polling

Aggregate polls
| Source of poll aggregation | Dates administered | Dates updated | Eric Schmitt (R) | Trudy Busch Valentine (D) | Undecided | Margin |
| RealClearPolitics | October 24 – November 1, 2022 | November 1, 2022 | 52.0% | 41.3% | 6.7% | Schmitt +10.7 |
| FiveThirtyEight | May 15 – November 4, 2022 | November 4, 2022 | 53.1% | 41.9% | 5.0% | Schmitt +11.2 |
| 270towin | October 29 – November 7, 2022 | November 7, 2022 | 52.0% | 40.8% | 7.2% | Schmitt +11.2 |
| Average | Average | Average | 52.4% | 41.3% | 6.3% | Schmitt +11.0 |
Graphical summary
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Schmitt (R) | Trudy Busch Valentine (D) | John Wood (I) | Other | Undecided |
| Civiqs | November 4–7, 2022 | 746 (LV) | ± 4.7% | 55% | 40% | – | 4% | 2% |
| The Trafalgar Group (R) | October 30 – November 1, 2022 | 1,079 (LV) | ± 2.9% | 53% | 42% | – | 2% | 2% |
| SurveyUSA | October 27 – November 1, 2022 | 791 (LV) | ± 4.1% | 50% | 41% | – | 3% | 6% |
| Emerson College | October 26–28, 2022 | 1,000 (LV) | ± 3.0% | 54% | 40% | – | 5% | – |
| Emerson College | October 26–28, 2022 | 1,000 (LV) | ± 3.0% | 51% | 39% | – | 4% | 6% |
| Remington Research (R) | October 24–25, 2022 | 1,011 (LV) | ± 3.0% | 51% | 42% | – | 3% | 4% |
| Emerson College | September 23–27, 2022 | 1,160 (VLV) | ± 2.8% | 49% | 38% | – | 3% | 10% |
| SurveyUSA | September 14–18, 2022 | 670 (LV) | ± 4.4% | 47% | 36% | – | 4% | 14% |
| Remington Research (R) | August 24–25, 2022 | 1,011 (LV) | ± 3.0% | 51% | 40% | – | 2% | 7% |
| | August 23, 2022 | Wood withdraws from the race | Wood withdraws from the race | Wood withdraws from the race | Wood withdraws from the race | Wood withdraws from the race | Wood withdraws from the race | Wood withdraws from the race |
| YouGov/SLU | August 8–16, 2022 | 900 (LV) | ± 3.8% | 49% | 38% | – | 5% | 8% |
| YouGov/SLU | August 8–16, 2022 | 900 (LV) | ± 3.8% | 44% | 31% | 10% | 3% | 13% |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 36% | 30% | 9% | 6% | 18% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 47% | 34% | – | – | 19% |
| Remington Research (R) | April 27–28, 2022 | 986 (LV) | ± 3.0% | 50% | 32% | – | – | 18% |
Eric Greitens vs. Lucas Kunce
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Lucas Kunce (D) | John Wood (I) | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 31% | 26% | 13% | 10% | 21% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 42% | 36% | – | – | 22% |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 46% | 45% | – | – | 9% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 34% | 26% | – | – | 40% |
| Fabrizio, Lee & Associates (R) | October 3–4, 2021 | 600 (LV) | ± 4.0% | 47% | 40% | – | – | 13% |
Eric Greitens vs. Trudy Busch Valentine
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Trudy Busch Valentine (D) | John Wood (I) | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 31% | 31% | 10% | 8% | 20% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 43% | 37% | – | – | 20% |
| Remington Research (R)/Missouri Scout | April 27–28, 2022 | 986 (LV) | ± 3.0% | 46% | 37% | – | – | 17% |
Vicky Hartzler vs. Lucas Kunce
| Poll source | Date(s) administered | Sample size | Margin of error | Vicky Hartzler (R) | Lucas Kunce (D) | John Wood (I) | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 34% | 25% | 12% | 9% | 20% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 45% | 31% | – | – | 24% |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 56% | 39% | – | – | 5% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 23% | 16% | – | – | 61% |
Vicky Hartzler vs. Trudy Busch Valentine
| Poll source | Date(s) administered | Sample size | Margin of error | Vicky Hartzler (R) | Trudy Busch Valentine (D) | John Wood (I) | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 32% | 31% | 9% | 7% | 21% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 44% | 33% | – | – | 23% |
| Remington Research (R)/Missouri Scout | April 27–28, 2022 | 986 (LV) | ± 3.0% | 49% | 33% | – | – | 18% |
Billy Long vs. Lucas Kunce
| Poll source | Date(s) administered | Sample size | Margin of error | Billy Long (R) | Lucas Kunce (D) | Undecided |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 16% | 17% | 67% |
Eric Schmitt vs. Lucas Kunce
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Schmitt (R) | Lucas Kunce (D) | John Wood (I) | Other | Undecided |
| SurveyUSA | July 24–27, 2022 | 1,591 (LV) | ± 3.0% | 37% | 27% | 10% | 6% | 20% |
| SurveyUSA | May 11–15, 2022 | 1,412 (LV) | ± 3.2% | 46% | 34% | – | – | 19% |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 55% | 40% | – | – | 5% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 28% | 23% | – | – | 49% |
Eric Greitens vs. Lucas Kunce vs. generic independent
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Lucas Kunce (D) | Generic Independent | Undecided |
| Bendixen & Amandi International (SAM) | February 2–6, 2022 | 800 (LV) | ± 3.5% | 27% | 25% | 26% | 22% |
Eric Greitens vs. Jay Nixon
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Jay Nixon (D) | Undecided |
| Remington Research (R)/Missouri Scout | July 14–15, 2021 | 922 (LV) | ± 3.0% | 48% | 44% | 8% |
| Remington Research (R)/Missouri Scout | April 7–8, 2021 | 936 (LV) | ± 3.0% | 48% | 44% | 8% |
Eric Greitens vs. Scott Sifton
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Scott Sifton (D) | Undecided |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 45% | 45% | 10% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 39% | 26% | 35% |
| Fabrizio, Lee & Associates (R) | October 3–4, 2021 | 600 (LV) | ± 4.0% | 46% | 40% | 14% |
| Remington Research (R)/Missouri Scout | April 7–8, 2021 | 936 (LV) | ± 3.0% | 49% | 42% | 9% |
| Remington Research (R)/Missouri Scout | February 17–18, 2021 | 954 (LV) | ± 3.0% | 49% | 41% | 10% |
Eric Greitens vs. generic Democrat
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Greitens (R) | Generic Democrat | Undecided |
| WPA Intelligence (R) | November 16–18, 2021 | 600 (LV) | ± 4.0% | 49% | 36% | 15% |
| Fabrizio, Lee & Associates (R) | October 3–4, 2021 | 600 (LV) | ± 4.0% | 47% | 41% | 12% |
Generic Republican vs. generic Democrat
| Poll source | Date(s) administered | Sample size | Margin of error | Generic Republican | Generic Democrat | Undecided |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 52% | 35% | 13% |
Vicky Hartzler vs. Scott Sifton
| Poll source | Date(s) administered | Sample size | Margin of error | Vicky Hartzler (R) | Scott Sifton (D) | Undecided |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 57% | 37% | 6% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 22% | 17% | 61% |
Billy Long vs. Scott Sifton
| Poll source | Date(s) administered | Sample size | Margin of error | Billy Long (R) | Scott Sifton (D) | Undecided |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 13% | 12% | 75% |
Eric Schmitt vs. Jay Nixon
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Schmitt (R) | Jay Nixon (D) | Undecided |
| Remington Research (R)/Missouri Scout | April 7–8, 2021 | 936 (LV) | ± 3.0% | 50% | 42% | 8% |
Eric Schmitt vs. Scott Sifton
| Poll source | Date(s) administered | Sample size | Margin of error | Eric Schmitt (R) | Scott Sifton (D) | Undecided |
| The Trafalgar Group (R) | March 9–13, 2022 | 1,075 (LV) | ± 3.0% | 54% | 40% | 6% |
| co/efficient (R) | December 16–17, 2021 | 1,210 (LV) | ± 4.2% | 23% | 18% | 60% |
| Remington Research (R)/Missouri Scout | April 7–8, 2021 | 936 (LV) | ± 3.0% | 51% | 39% | 10% |
Roy Blunt vs. Jason Kander
| Poll source | Date(s) administered | Sample size | Margin of error | Roy Blunt (R) | Jason Kander (D) | Undecided |
| Data for Progress (D) | January 10–12, 2021 | 571 (LV) | ± 4.1% | 45% | 44% | 12% |
Roy Blunt vs. Scott Sifton
| Poll source | Date(s) administered | Sample size | Margin of error | Roy Blunt (R) | Scott Sifton (D) | Undecided |
| Remington Research (R)/Missouri Scout | February 17–18, 2021 | 954 (LV) | ± 3.0% | 50% | 40% | 10% |
| Remington Research (R)/Missouri Scout | January 6–7, 2021 | 980 (LV) | ± 3.0% | 52% | 34% | 14% |

### Results

Schmitt prevailed over Valentine on Election Day.
2022 United States Senate election in Missouri :
| Party | Party | Candidate | Votes | % | ±% |
| | Republican | Eric Schmitt | 1,146,966 | 55.43% | +6.25% |
| | Democratic | Trudy Busch Valentine | 872,694 | 42.18% | −4.21% |
| | Libertarian | Jonathan Dine | 34,821 | 1.68% | −0.74% |
| | Constitution | Paul Venable | 14,608 | 0.71% | −0.20% |
| | Write-in | Write-in | 41 | 0.00% | −0.03% |
| Total votes | Total votes | Total votes | 2,069,130 | 100.0% | |
| | Republican hold | Republican hold | Republican hold | Republican hold | Republican hold |

#### Counties that flipped from Democratic to Republican

* Clay (Largest city: Kansas City)
* Platte (Largest city: Kansas City)

#### By congressional district

Schmitt won 6 of 8 congressional districts.
| District | Schmitt | Busch Valentine | Representative |
| 1st | 20% | 79% | Cori Bush |
| 2nd | 51% | 48% | Ann Wagner |
| 3rd | 59% | 38% | Blaine Luetkemeyer |
| 4th | 66% | 31% | Vicky Hartzler (117th Congress) |
| 4th | 66% | 31% | Mark Alford (118th Congress) |
| 5th | 35% | 62% | Emanuel Cleaver |
| 6th | 65% | 32% | Sam Graves |
| 7th | 68% | 29% | Billy Long (117th Congress) |
| 7th | 68% | 29% | Eric Burlison (118th Congress) |
| 8th | 73% | 24% | Jason Smith |