# 2021 US Open – Women's singles

Emma Raducanu defeated Leylah Fernandez in the final, 6–4, 6–3 to win the women's singles tennis title at the 2021 US Open. It was her first major title. Raducanu became the first qualifier to win a major. Additionally, she became the first British woman to win a singles major since Virginia Wade at the 1977 Wimbledon Championships, and the second player to win the US Open on her tournament debut (after Bianca Andreescu in 2019). Aged 18, Raducanu was the youngest major champion since Maria Sharapova at the 2004 Wimbledon Championships, and with a ranking of world No. 150, the lowest-ranked player to win a major since Kim Clijsters at the 2009 US Open. She did not lose a set during the tournament, including during her three qualification matches, and was not taken to a tiebreak in any set. This was her first WTA Tour-level singles title, making her the fourth woman in the Open Era to win a major as her first singles title. Raducanu won the title on only her second major main-draw appearance, an Open Era record.
Naomi Osaka was the defending champion, but was defeated by Fernandez in the third round.
The final marked the first all-teenage major final since Serena Williams defeated Martina Hingis at the 1999 US Open, and the first women's singles major final in the Open Era to feature two unseeded players. Raducanu and Fernandez both made their top 30 debuts following the tournament. Fernandez was the youngest player to defeat three top-five seeded players in the same major since Williams at the 1999 US Open. She was the first player of Southeast Asian descent (Filipino descent) to reach the final.
This was the first major since the 2011 French Open and first US Open since 2003 where neither of the Williams sisters participated.
None of the top 20 seeds lost prior to the third round, the first time this occurred since the introduction of the 32-seed format in 2001. The defeats of Karolína Plíšková and Barbora Krejčíková in the quarterfinals guaranteed two first-time major finalists; Raducanu and Fernandez emerged to become those players. This also ensured that, for the first time since 2014, eight different players contested the four major finals in a season.
This marked the final US Open appearance of 2016 champion and former world No. 1 Angelique Kerber; she lost to Fernandez in the fourth round. Kerber subsequently went on maternity leave in 2023 and retired from professional tennis in 2024.

## Seeds

    01. Ashleigh Barty (third round)
    02. Aryna Sabalenka (semifinals)
    03. Naomi Osaka (third round)
    04. Karolína Plíšková (quarterfinals)
    05. Elina Svitolina (quarterfinals)
    06. Bianca Andreescu (fourth round)
    07. Iga Świątek (fourth round)
    08. Barbora Krejčíková (quarterfinals)
    09. Garbiñe Muguruza (fourth round)
    10. Petra Kvitová (third round)
    11. Belinda Bencic (quarterfinals)
    12. Simona Halep (fourth round)
    13. Jennifer Brady (withdrew)
    14. Anastasia Pavlyuchenkova (fourth round)
    15. Elise Mertens (fourth round)
    16. Angelique Kerber (fourth round)
    17. Maria Sakkari (semifinals)
    18. Victoria Azarenka (third round)
    19. Elena Rybakina (third round)
    20. Ons Jabeur (third round)
    21. Coco Gauff (second round)
    22. Karolína Muchová (first round)
    23. Jessica Pegula (third round)
    24. Paula Badosa (second round)
    25. Daria Kasatkina (third round)
    26. Danielle Collins (third round)
    27. Jeļena Ostapenko (withdrew)
    28. Anett Kontaveit (third round)
    29. Veronika Kudermetova (first round)
    30. Petra Martić (second round)
    31. Yulia Putintseva (first round)
    32. Ekaterina Alexandrova (second round)
Click on the seed number of a player to go to their draw section.

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| Q | Emma Raducanu | 6 | 6 | | | | | | | | | | |
| 11 | Belinda Bencic | 3 | 4 | | | | | | | | | | |
| 11 | Belinda Bencic | 3 | 4 | | Q | Emma Raducanu | 6 | 6 | | | | | |
| | | | | | 17 | Maria Sakkari | 1 | 4 | | | | | |
| 4 | Karolína Plíšková | 4 | 4 | | 17 | Maria Sakkari | 1 | 4 | | | | | |
| 17 | Maria Sakkari | 6 | 6 | | | | | | | | | | |
| 17 | Maria Sakkari | 6 | 6 | | | | | | | Q | Emma Raducanu | 6 | 6 |
| | | | | | | | | | | | Leylah Fernandez | 4 | 3 |
| 5 | Elina Svitolina | 3 | 6 | 6$^5$ | | | | | | | | | | Leylah Fernandez | 4 | 3 |
| | Leylah Fernandez | 6 | 3 | 7$^7$ | | | | | | | | | |
| | Leylah Fernandez | 6 | 3 | 7$^7$ | | Leylah Fernandez | 7$^7$ | 4 | 6 | | | | |
| | | | | | 2 | Aryna Sabalenka | 6$^3$ | 6 | 4 | | | | |
| 8 | Barbora Krejčíková | 1 | 4 | | 2 | Aryna Sabalenka | 6$^3$ | 6 | 4 | | | | |
| 2 | Aryna Sabalenka | 6 | 6 | | | | | | | | | | |

### Top half
#### Section 1

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 1 | A Barty | 6 | 7$^9$ | | | | | | | | | | | | | | |
| | V Zvonareva | 1 | 6$^7$ | | 1 | A Barty | 6 | 7 | | | | | | | | | |
| | C Burel | 5 | 0 | | | C Tauson | 1 | 5 | | | | | | | | | |
| | C Tauson | 7 | 6 | | | | | | 1 | A Barty | 2 | 6 | 6$^5$ | | | | |
| | S Rogers | 6 | 6 | | | | | | | S Rogers | 6 | 1 | 7$^7$ | | | | |
| | M Brengle | 4 | 0 | | | S Rogers | 7 | 6 | | | | | | | | | |
| | S Cîrstea | 7$^7$ | 3 | 6 | | S Cîrstea | 5 | 2 | | | | | | | | | |
| 29 | V Kudermetova | 6$^5$ | 6 | 0 | | | | | | | | | | | S Rogers | 2 | 1 |
| 22 | K Muchová | 2 | 6$^3$ | | | | | | | | | | | Q | E Raducanu | 6 | 6 |
| | S Sorribes Tormo | 6 | 7$^7$ | | | S Sorribes Tormo | 6 | 6 | | | | | | | | | |
| | S-w Hsieh | 6 | 6 | | | S-w Hsieh | 1 | 3 | | | | | | | | | |
| | C Liu | 1 | 4 | | | | | | | S Sorribes Tormo | 0 | 1 | | | | | |
| WC | H Baptiste | 3 | 4 | | | | | | Q | E Raducanu | 6 | 6 | | | | | |
| | S Zhang | 6 | 6 | | | S Zhang | 2 | 4 | | | | | | | | | |
| Q | E Raducanu | 6 | 6 | | Q | E Raducanu | 6 | 6 | | | | | | | | | |
| LL | S Vögele | 2 | 3 | | | | | | | | | | | | | | |

#### Section 2

| First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 11 | B Bencic | 6 | 6 | | | | | | | | | | | | | | |
| | A Rus | 4 | 4 | 11 | B Bencic | 6 | 6 | | | | | | | | | | |
| | M Trevisan | 6 | 7 | | M Trevisan | 3 | 1 | | | | | | | | | | |
| WC | C Vandeweghe | 1 | 5 | | | | | | 11 | B Bencic | 6 | 6 | | | | | |
| | M Doi | 7$^7$ | 6 | | | | | | 23 | J Pegula | 2 | 4 | | | | | |
| WC | S Sanders | 6$^3$ | 3 | | M Doi | 3 | 2 | | | | | | | | | | |
| | A Potapova | 2 | 2 | 23 | J Pegula | 6 | 6 | | | | | | | | | | |
| 23 | J Pegula | 6 | 6 | | | | | | | | | | | 11 | B Bencic | 7$^{14}$ | 6 |
| 28 | A Kontaveit | 6 | 6 | | | | | | | | | | | 7 | I Świątek | 6$^{12}$ | 3 |
| PR | S Stosur | 3 | 0 | 28 | A Kontaveit | 6 | 6 | | | | | | | | | | |
| Q | C Bucșa | 3 | 4 | | J Teichmann | 4 | 1 | | | | | | | | | | |
| | J Teichmann | 6 | 6 | | | | | | 28 | A Kontaveit | 3 | 6 | 3 | | | | |
| | F Ferro | 6 | 6 | | | | | | 7 | I Świątek | 6 | 4 | 6 | | | | |
| | N Hibino | 1 | 4 | | F Ferro | 6 | 6$^3$ | 0 | | | | | | | | | |
| Q | J Loeb | 3 | 4 | 7 | I Świątek | 3 | 7$^7$ | 6 | | | | | | | | | |
| 7 | I Świątek | 6 | 6 | | | | | | | | | | | | | | |

#### Section 3

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 4 | Ka Plíšková | 6 | 6 | | | | | | | | | | | | | | |
| WC | C McNally | 3 | 4 | | 4 | Ka Plíšková | 7 | 6$^5$ | 7$^9$ | | | | | | | | |
| | Z Diyas | 5 | 2 | | | A Anisimova | 5 | 7$^7$ | 6$^7$ | | | | | | | | |
| | A Anisimova | 7 | 6 | | | | | | | 4 | Ka Plíšková | 6 | 6 | | | | |
| | A Tomljanović | 6 | 6 | | | | | | | | A Tomljanović | 3 | 2 | | | | |
| WC | K Volynets | 3 | 1 | | | A Tomljanović | 7$^8$ | 6 | | | | | | | | | |
| Q | D Gálfi | 3 | 2 | | 30 | P Martić | 6$^6$ | 4 | | | | | | | | | |
| 30 | P Martić | 6 | 6 | | | | | | | | | | | 4 | Ka Plíšková | 7 | 6 |
| 24 | P Badosa | 6 | 6 | | | | | | | | | | | 14 | A Pavlyuchenkova | 5 | 4 |
| | A Van Uytvanck | 4 | 3 | | 24 | P Badosa | 4 | 4 | | | | | | | | | |
| | V Gracheva | 5 | 6 | 6 | | V Gracheva | 6 | 6 | | | | | | | | | |
| Q | N Párrizas Díaz | 7 | 0 | 2 | | | | | | | V Gracheva | 1 | 4 | | | | |
| Q | AK Schmiedlová | 7 | 6$^3$ | 6 | | | | | | 14 | A Pavlyuchenkova | 6 | 6 | | | | |
| WC | A Krueger | 5 | 7$^7$ | 3 | Q | AK Schmiedlová | 2 | 7 | 2 | | | | | | | | |
| | A Riske | 4 | 2 | | 14 | A Pavlyuchenkova | 6 | 5 | 6 | | | | | | | | |
| 14 | A Pavlyuchenkova | 6 | 6 | | | | | | | | | | | | | | |

#### Section 4

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round | Fourth round |
| 10 | P Kvitová | 6 | 6 | | | | | | | | | | | | | | |
| | P Hercog | 1 | 2 | | 10 | P Kvitová | 7$^7$ | 6 | | | | | | | | | |
| | D Kovinić | 4 | 3 | | Q | Kr Plíšková | 6$^4$ | 2 | | | | | | | | | |
| Q | Kr Plíšková | 6 | 6 | | | | | | 10 | P Kvitová | 4 | 3 | | | | | |
| | A Sevastova | 6$^6$ | 3 | | | | | | 17 | M Sakkari | 6 | 6 | | | | | |
| | K Siniaková | 7$^8$ | 6 | | | K Siniaková | 4 | 2 | | | | | | | | | |
| | M Kostyuk | 4 | 3 | | 17 | M Sakkari | 6 | 6 | | | | | | | | | |
| 17 | M Sakkari | 6 | 6 | | | | | | | | | | 17 | M Sakkari | 6$^2$ | 7$^8$ | 6 |
| LL | G Minnen | 6 | 1 | 6 | | | | | | | | | 6 | B Andreescu | 7$^7$ | 6$^6$ | 3 |
| | N Podoroska | 4 | 6 | 3 | LL | G Minnen | 6 | 6 | | | | | | | | | |
| | L Samsonova | 6 | 6 | | | L Samsonova | 4 | 4 | | | | | | | | | |
| Q | K Boulter | 3 | 2 | | | | | | LL | G Minnen | 1 | 2 | | | | | |
| | L Davis | 6 | 2 | 6 | | | | | 6 | B Andreescu | 6 | 6 | | | | | |
| LL | V Tomova | 2 | 6 | 3 | | L Davis | 4 | 4 | | | | | | | | | |
| | V Golubic | 5 | 6 | 5 | 6 | B Andreescu | 6 | 6 | | | | | | | | | |
| 6 | B Andreescu | 7 | 4 | 7 | | | | | | | | | | | | | |

### Bottom half
#### Section 5

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 5 | E Svitolina | 6 | 6 | | | | | | | | | | | | | | | |
| Q | R Marino | 2 | 3 | | 5 | E Svitolina | 6 | 7 | | | | | | | | | | |
| Q | R Masarova | 6$^9$ | 7$^7$ | 7$^{11}$ | Q | R Masarova | 2 | 5 | | | | | | | | | | |
| | A Bogdan | 7$^{11}$ | 6$^2$ | 6$^9$ | | | | | | 5 | E Svitolina | 6 | 6 | | | | | |
| | M Vondroušová | 7 | 6 | | | | | | | 25 | D Kasatkina | 4 | 2 | | | | | |
| Q | E-G Ruse | 5 | 0 | | | M Vondroušová | 6 | 4 | 4 | | | | | | | | | |
| | T Pironkova | 2 | 1 | | 25 | D Kasatkina | 3 | 6 | 6 | | | | | | | | | |
| 25 | D Kasatkina | 6 | 6 | | | | | | | | | | | | 5 | E Svitolina | 6 | 6 |
| 19 | E Rybakina | 6 | 6 | | | | | | | | | | | | 12 | S Halep | 3 | 3 |
| | A Sasnovich | 2 | 3 | | 19 | E Rybakina | 6 | 6 | | | | | | | | | | |
| | C Garcia | 6$^6$ | 6 | 6 | | C Garcia | 1 | 4 | | | | | | | | | | |
| Q | H Dart | 7$^8$ | 4 | 2 | | | | | | 19 | E Rybakina | 6$^{11}$ | 6 | 3 | | | | |
| | A Li | 5 | 1 | | | | | | | 12 | S Halep | 7$^{13}$ | 4 | 6 | | | | |
| LL | K Kučová | 7 | 6 | | LL | K Kučová | 3 | 1 | | | | | | | | | | |
| | C Giorgi | 4 | 6$^3$ | | 12 | S Halep | 6 | 6 | | | | | | | | | | |
| 12 | S Halep | 6 | 7$^7$ | | | | | | | | | | | | | | | |

#### Section 6

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round | Fourth round |
| 16 | A Kerber | 3 | 6 | 7$^7$ | | | | | | | | | | | | | | |
| | D Yastremska | 6 | 4 | 6$^3$ | 16 | A Kerber | 6 | 6 | | | | | | | | | | |
| LL | M Sherif | 6 | 1 | 1 | | A Kalinina | 3 | 2 | | | | | | | | | | |
| | A Kalinina | 4 | 6 | 6 | | | | | 16 | A Kerber | 5 | 6 | 6 | | | | | |
| | M Keys | 3 | 6 | 6$^7$ | | | | | | S Stephens | 7 | 2 | 3 | | | | | |
| | S Stephens | 6 | 1 | 7$^9$ | | S Stephens | 6 | 6 | | | | | | | | | | |
| | M Linette | 7 | 3 | 4 | 21 | C Gauff | 4 | 2 | | | | | | | | | | |
| 21 | C Gauff | 5 | 6 | 6 | | | | | | | | | | 16 | A Kerber | 6 | 6$^5$ | 2 |
| 31 | Y Putintseva | 6 | 6$^4$ | 2 | | | | | | | | | | | L Fernandez | 4 | 7$^7$ | 6 |
| | K Kanepi | 2 | 7$^7$ | 6 | | K Kanepi | 5 | 5 | | | | | | | | | | |
| | L Fernandez | 7$^7$ | 6 | | | L Fernandez | 7 | 7 | | | | | | | | | | |
| Q | A Konjuh | 6$^3$ | 2 | | | | | | | L Fernandez | 5 | 7$^7$ | 6 | | | | | |
| WC | A Parks | 3 | 5 | | | | | | 3 | N Osaka | 7 | 6$^2$ | 4 | | | | | |
| Q | O Danilović | 6 | 7 | | Q | O Danilović | | | | | | | | | | | | |
| | M Bouzková | 4 | 1 | | 3 | N Osaka | w/o | | | | | | | | | | | |
| 3 | N Osaka | 6 | 6 | | | | | | | | | | | | | | | |

#### Section 7

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 8 | B Krejčíková | 6 | 6 | | | | | | | | | | | | | | |
| Q | A Sharma | 0 | 4 | | 8 | B Krejčíková | 6 | 6 | | | | | | | | | |
| WC | E Navarro | 1 | 6$^5$ | | | C McHale | 3 | 1 | | | | | | | | | |
| | C McHale | 6 | 7$^7$ | | | | | | 8 | B Krejčíková | 6 | 6 | | | | | |
| | K Mladenovic | 6 | 2 | 3 | | | | | LL | K Rakhimova | 4 | 2 | | | | | |
| LL | K Rakhimova | 2 | 6 | 6 | LL | K Rakhimova | 6 | 6 | | | | | | | | | |
| | S Errani | 3 | 2 | | 32 | E Alexandrova | 4 | 1 | | | | | | | | | |
| 32 | E Alexandrova | 6 | 6 | | | | | | | | | | | 8 | B Krejčíková | 6 | 7$^7$ |
| 18 | V Azarenka | 6 | 6 | | | | | | | | | | | 9 | G Muguruza | 3 | 6$^4$ |
| | T Martincová | 4 | 0 | | 18 | V Azarenka | 6 | 7$^7$ | | | | | | | | | |
| | J Paolini | 6 | 6 | | | J Paolini | 3 | 6$^1$ | | | | | | | | | |
| PR | Y Shvedova | 3 | 4 | | | | | | 18 | V Azarenka | 4 | 6 | 2 | | | | |
| | A Petkovic | 6 | 7$^7$ | | | | | | 9 | G Muguruza | 6 | 3 | 6 | | | | |
| | I-C Begu | 2 | 6$^3$ | | | A Petkovic | 4 | 2 | | | | | | | | | |
| | D Vekić | 6$^4$ | 6$^5$ | | 9 | G Muguruza | 6 | 6 | | | | | | | | | |
| 9 | G Muguruza | 7$^7$ | 7$^7$ | | | | | | | | | | | | | | |

#### Section 8

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Third round | Third round | Third round | Third round | Fourth round | Fourth round | Fourth round | Fourth round |
| 15 | E Mertens | 3 | 7$^7$ | 7$^7$ | | | | | | | | | | | | |
| | R Peterson | 6 | 6$^5$ | 6$^5$ | 15 | E Mertens | 6 | 6 | | | | | | | | |
| Q | V Grammatikopoulou | 6 | 6 | | Q | V Grammatikopoulou | 2 | 2 | | | | | | | | |
| | A Blinkova | 3 | 2 | | | | | | 15 | E Mertens | 6 | 7 | | | | |
| PR | I Jorović | 2 | 2 | | | | | | 20 | O Jabeur | 3 | 5 | | | | |
| | C Osorio | 6 | 6 | | | C Osorio | 0 | 1 | | | | | | | | |
| | A Cornet | 5 | 5 | | 20 | O Jabeur | 6 | 6 | | | | | | | | |
| 20 | O Jabeur | 7 | 7 | | | | | | | | | | 15 | E Mertens | 4 | 1 |
| 26 | D Collins | 6 | 6 | | | | | | | | | | 2 | A Sabalenka | 6 | 6 |
| PR | C Suárez Navarro | 2 | 4 | | 26 | D Collins | 6 | 6 | | | | | | | | |
| | H Watson | 1 | 4 | | | K Juvan | 4 | 2 | | | | | | | | |
| | K Juvan | 6 | 6 | | | | | | 26 | D Collins | 3 | 3 | | | | |
| | B Pera | 4 | 6$^4$ | | | | | | 2 | A Sabalenka | 6 | 6 | | | | |
| | T Zidanšek | 6 | 7$^7$ | | | T Zidanšek | 3 | 1 | | | | | | | | |
| | N Stojanović | 4 | 7$^7$ | 0 | 2 | A Sabalenka | 6 | 6 | | | | | | | | |
| 2 | A Sabalenka | 6 | 6$^4$ | 6 | | | | | | | | | | | | |

## Championship match statistics

| Category | Raducanu | Fernandez |
| 1st serve % | 49/71 (69%) | 45/78 (58%) |
| 1st serve points won | 33 of 49 = 67% | 25 of 45 = 56% |
| 2nd serve points won | 10 of 22 = 45% | 15 of 33 = 45% |
| Total service points won | 43 of 71 = 57.33% | 40 of 78 = 51.28% |
| Aces | 3 | 2 |
| Double faults | 2 | 5 |
| Winners | 22 | 18 |
| Unforced errors | 25 | 26 |
| Net points won | 11 of 15 = 73% | 9 of 12 = 75% |
| Break points converted | 4 of 18 = 22% | 2 of 9 = 22% |
| Return points won | 38 of 78 = 49% | 28 of 71 = 43% |
| Total points won | 81 | 68 |
| Source |||

## Seeded players

The following are the seeded players. Seedings are based on WTA rankings as of August 23, 2021. Rank and points before are as of August 30, 2021.
As a result of pandemic-related adjustments to the ranking system, players are defending the greater of their points from the 2019 and 2020 tournaments. In addition, points from tournaments held during the weeks of September 9, 2019 and September 7, 2020 will be dropped at the end of the tournament and replaced by the player's next best result.
| Seed | Rank | Player | Points before | Points defending from 2019 or 2020 | Points won | Points after | Status |
| 1 | 1 | Ashleigh Barty | 10,185 | 240 | 130 | 10,075 | Third round lost to Shelby Rogers |
| 2 | 2 | Aryna Sabalenka | 7,010 | 70 | 780 | 7,720 | Semifinals lost to Leylah Fernandez |
| 3 | 3 | Naomi Osaka | 6,666 | 2,000 | 130 | 4,796 | Third round lost to Leylah Fernandez |
| 4 | 4 | Karolína Plíšková | 5,530 | 240+470 | 430+65 | 5,315 | Quarterfinals lost to Maria Sakkari [17] |
| 5 | 5 | Elina Svitolina | 5,210 | 780 | 430 | 4,860 | Quarterfinals lost to Leylah Fernandez |
| 6 | 7 | Bianca Andreescu | 4,537 | 2,000 | 240 | 2,777 | Fourth round lost to Maria Sakkari [17] |
| 7 | 8 | Iga Świątek | 4,461 | 130 | 240 | 4,571 | Fourth round lost to Belinda Bencic [11] |
| 8 | 9 | Barbora Krejčíková | 4,273 | (35)$^†$ | 430 | 4,668 | Quarterfinals lost to Aryna Sabalenka [2] |
| 9 | 10 | Garbiñe Muguruza | 4,210 | 70 | 240 | 4,380 | Fourth round lost to Barbora Krejčíková [8] |
| 10 | 11 | Petra Kvitová | 4,170 | 240 | 130 | 4,060 | Third round lost to Maria Sakkari [17] |
| 11 | 12 | Belinda Bencic | 4,170 | 780 | 430 | 3,820 | Quarterfinals lost to Emma Raducanu [Q] |
| 12 | 13 | Simona Halep | 3,881 | 70 | 240 | 4,051 | Fourth round lost to Elina Svitolina [5] |
| 13 | 14 | Jennifer Brady | 3,489 | 780+29 | 0+15 | 2,695 | Withdrew due to injury |
| 14 | 15 | Anastasia Pavlyuchenkova | 3,420 | 70 | 240 | 3,590 | Fourth round lost to Karolína Plíšková [4] |
| 15 | 16 | Elise Mertens | 3,330 | 430 | 240 | 3,140 | Fourth round lost to Aryna Sabalenka [2] |
| 16 | 17 | Angelique Kerber | 3,245 | 240 | 240 | 3,245 | Fourth round lost to Leylah Fernandez |
| 17 | 18 | Maria Sakkari | 3,210 | 240 | 780 | 3,750 | Semifinals lost to Emma Raducanu [Q] |
| 18 | 19 | Victoria Azarenka | 3,160 | 1,300 | 130 | 1,990 | Third round lost to Garbiñe Muguruza [9] |
| 19 | 20 | Elena Rybakina | 3,083 | 70+180 | 130+105 | 3,068 | Third round lost to Simona Halep [12] |
| 20 | 21 | Ons Jabeur | 2,975 | 130 | 130 | 2,975 | Third round lost to Elise Mertens [15] |
| 21 | 23 | Coco Gauff | 2,875 | 130 | 70 | 2,815 | Second round lost to Sloane Stephens |
| 22 | 24 | Karolína Muchová | 2,862 | 240 | 10 | 2,632 | First round lost to Sara Sorribes Tormo |
| 23 | 25 | Jessica Pegula | 2,425 | 130 | 130 | 2,425 | Third round lost to Belinda Bencic [11] |
| 24 | 26 | Paula Badosa | 2,343 | 30+110 | 70+30 | 2,303 | Second round lost to Varvara Gracheva |
| 25 | 27 | Daria Kasatkina | 2,340 | 10 | 130 | 2,460 | Third round lost to Elina Svitolina [5] |
| 26 | 29 | Danielle Collins | 2,270 | 70 | 130 | 2,330 | Third round lost to Aryna Sabalenka [2] |
| 27 | 30 | Jeļena Ostapenko | 2,170 | 130 | 0 | 2,040 | Withdrew for medical reasons |
| 28 | 28 | Anett Kontaveit | 2,315 | 240 | 130 | 2,205 | Third round lost to Iga Świątek [7] |
| 29 | 31 | Veronika Kudermetova | 2,040 | 10+110 | 10+100 | 2,030 | First round lost to Sorana Cîrstea |
| 30 | 32 | Petra Martić | 2,005 | 240+305 | 70+55 | 1,585 | Second round lost to Ajla Tomljanović |
| 31 | 33 | Yulia Putintseva | 1,910 | 430 | 10 | 1,490 | First round lost to Kaia Kanepi |
| 32 | 34 | Ekaterina Alexandrova | 1,866 | 70 | 70 | 1,866 | Second round lost to Kamilla Rakhimova [LL] |
† The player did not qualify for the tournament in 2019 or 2020. Accordingly, points for her 16th best result are deducted instead.

### Withdrawn players

The following players would have been seeded, but withdrew before the tournament began.
| Rank | Player | Points before | Points defending from 2019 or 2020 | Points after | Withdrawal reason |
| 6 | Sofia Kenin | 5,030 | 240+100 | 4,691 | Positive COVID-19 test |
| 22 | Serena Williams | 2,891 | 1,300 | 1,591 | Hamstring injury in right leg |

## Other entry information
### Wild card entries

* Hailey Baptiste
* Ashlyn Krueger
* Caty McNally
* Emma Navarro
* Alycia Parks
* Storm Sanders
* CoCo Vandeweghe
* Katie Volynets

### Qualifiers

* Katie Boulter
* Cristina Bucșa
* Olga Danilović
* Harriet Dart
* Dalma Gálfi
* Valentini Grammatikopoulou
* Ana Konjuh
* Jamie Loeb
* Rebecca Marino
* Rebeka Masarova
* Nuria Párrizas Díaz
* Kristýna Plíšková
* Emma Raducanu
* Elena-Gabriela Ruse
* Anna Karolína Schmiedlová
* Astra Sharma

### Lucky losers

* Kristína Kučová
* Greet Minnen
* Kamilla Rakhimova
* Mayar Sherif
* Viktoriya Tomova
* Stefanie Vögele

### Protected ranking

* Ivana Jorović (90)
* Yaroslava Shvedova (47)
* Samantha Stosur (97)
* Carla Suárez Navarro (68)

### Withdrawals

* † Kiki Bertens (21) → replaced by Ana Bogdan (101)
* † Svetlana Kuznetsova (41) → replaced by Martina Trevisan (102)
* † Zheng Saisai (52) → replaced by Tsvetana Pironkova (103)
* † Zhu Lin (93) → replaced by Sara Errani (104)
* & Patricia Maria Țig (74) → replaced by Claire Liu (106)
* & Laura Siegemund (61) → replaced by Kaja Juvan (107)
* & Wang Qiang (49) → replaced by Kristína Kučová (LL)
* & Sofia Kenin (4) → replaced by Viktoriya Tomova (LL)
* & Jennifer Brady (15) → replaced by Stefanie Vögele (LL)
* & Serena Williams (16) → replaced by Mayar Sherif (LL)
* & Jeļena Ostapenko (30) → replaced by Greet Minnen (LL)
* & Johanna Konta (40) → replaced by Kamilla Rakhimova (LL)
† – not included on entry list & – withdrew from entry list