# List of AM cannabinoids

Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are:
Cannabinoids and their affinities, selectivities and structures :
| Name | Class | K$_i$ / nM at CB$_1$ | K$_i$ / nM at CB$_2$ | Selectivity | CLogP | Description |
| AM-087 | Dibenzopyran | 0.43 | | | 6.47 | An analgesic CB$_1$ agonist derived from Δ$^8$-THC substituted with a side chain on the 3-position, roughly 100 times as potent as THC. |
| AM-251 | Pyrazole derivative | 7.5 | | | 7.08 | An inverse agonist at the CB$_1$ cannabinoid receptor that is structurally related to SR141716A (rimonabant), but has a higher binding affinity. |
| AM-279 | | | | | | A Schedule I substance in Alabama. |
| AM-281 | | | | | | N-(morpholin-4-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
| AM-356 | | 17.9 | 868 | | 5.55 | A synthetically created stable chiral analog of anandamide, it acts on both cannabinoid receptors. |
| AM-374 | | | | | | Palmitylsulfonyl fluoride |
| AM-381 | | | | | | Stearylsulfonyl fluoride |
| AM-404 | | | | | 7.02 | An active metabolite of paracetamol (acetaminophen) and a likely inhibitor of fatty acid amide hydrolase (FAAH) |
| AM-411 | | 6.80 | 52.0 | | | An adamantyl-substituted derivative of Δ$^8$-THC, it is a potent and fairly selective CB$_1$ full agonist and a moderately potent CB$_2$ agonist. |
| AM-630 | | | 32.1 | CB$_2$ (165×) | 4.19 | A potent and selective inverse agonist for the cannabinoid receptor CB$_2$ and a weak partial agonist at CB$_1$. |
| AM-661 | | | | | | 1-(N-methyl-2-piperidine)methyl-2-methyl-3-(2-iodo)benzoylindole |
| AM-678 | | 9.00 ± 5.00 | 2.94 ± 2.65 | CB$_2$ | 5.68 | Another name for JWH-018, it is a full agonist at both cannabinoid receptors with some selectivity for CB$_2$. |
| AM-679 | | 13.5 | 49.5 | | 6.04 | An iodobenzoylindole which acts as a moderately potent agonist for both cannabinoid receptors. |
| AM-694 | | 0.08 | 1.44 | CB$_1$ (18×) | 5.54 | An iodobenzoylindole which acts as a potent and selective agonist for the CB$_1$ cannabinoid receptor. |
| AM-735 | | 8.9 | 7.4 | | | 3-bornyl-Δ8-THC, a mixed CB$_1$ / CB$_2$ agonist. |
| AM-855 | | 22.3 | 58.6 | CB$_1$ | 7.1 | An analgesic derivative of Δ$^8$-tetrahydrocannabinol, it is an agonist at both CB$_1$ and CB$_2$ with moderate selectivity for CB$_1$. |
| AM-881 | | 5.3 | 95 | | | A chlorine-substituted stereoisomer of anandamide. |
| AM-883 | | 9.9 | 226 | | | An allyl-substituted stereoisomer of anandamide. |
| AM-905 | | 1.2 | 5.3 | CB$_1$ | 4.98 | A potent and reasonably selective agonist for the CB$_1$ cannabinoid receptor. |
| AM-906 | | 0.8 | 9.5 | CB$_1$ | 4.98 | A potent and dodecally selective agonist for the CB$_1$ cannabinoid receptor. |
| AM-919 | | 2.2 | 3.4 | CB$_1$ | 6.21 | A potent agonist at both CB$_1$ and CB$_2$ with moderate selectivity for CB$_1$. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. |
| AM-926 | | 2.2 | 4.3 | CB$_1$ | | A potent agonist at both CB$_1$ and CB$_2$ with moderate selectivity for CB$_1$. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. |
| AM-938 | | 1.2 | 0.3 | CB$_2$ (4×) | 5.92 | A potent agonist at both CB$_1$ and CB$_2$. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. |
| AM-1116 | | 7.4 | | | | A dimethylated stereoisomer of anandamide. |
| AM-1172 | | | | | | An endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis. |
| AM-1220 | | 3.88 | 73.4 | CB$_1$ (19×) | 4.73 | A potent and selective analgesic CB$_1$ agonist (as racemate). The (R) enantiomer has around 1000× higher affinity for CB$_1$ than (S) enantiomer. |
| AM-1221 | | 52.3 | 0.28 | CB$_2$ (187×) | | A potent and selective CB$_2$ agonist. |
| AM-1235 | | 1.5 | 20.4 | CB$_1$ (13×) | | A moderately CB$_1$ selective agonist. |
| AM-1241 | | | 3.4 | CB$_2$ (80×) | | A potent and selective analgesic CB$_2$ agonist. |
| AM-1248 | | | | CB$_1$ | | A moderately potent agonist with some selectivity for CB$_1$, containing an unusual 3-(adamant-1-oyl) substitution on the indole ring. |
| AM-1710 | Cannabilactone | | | CB$_2$ (54×) | | A CB$_2$ selective cannabilactone. Acts as a dual CB$_2$ agonist / CB$_1$ antagonist. |
| AM-1714 | Cannabilactone | | | CB$_2$ (490×) | 6.17 | A CB$_2$ selective cannabilactone. |
| AM-1902 | | | | | | A nonclassical cannabinoid |
| AM-2201 | | 1.0 | 2.6 | CB$_1$ | 5.18 | A potent agonist at both CB$_1$ and CB$_2$ with moderate selectivity for CB$_1$. |
| AM-2212 | | 1.4 | 18.9 | CB$_1$ | | A potent agonist at both CB$_1$ and CB$_2$ with dodecal selectivity for CB$_1$. |
| AM-2213 | | 3.0 | 30 | CB$_1$ (10×) | | A potent agonist at both CB$_1$ and CB$_2$. |
| AM-2232 | | 0.28 | 1.48 | | 4.75 | A potent agonist at both CB$_1$ and CB$_2$. |
| AM-2233 | | 1.8 | 2.2 | CB$_1$ | 5.09 | The (R) enantiomer is potent and selective CB$_1$ agonist used in $^{131}$I radiolabelled form to map distribution of CB$_1$ receptors in brain. |
| AM-2389 | | 0.16 | | CB$_1$ (26×) | 6 | Classical cannabinoid derivative. |
| AM-3102 | | 33000 | 26000 | | | An analog of oleoylethanolamide, the endogenous agonist for proliferator-activated receptor α (PPARα). It also acts as a weak cannabinoid agonist. |
| AM-4030 | | 0.7 | 8.6 | CB$_1$ (12×) | 6.17 | A potent agonist at both CB$_1$ and CB$_2$, it is dodecally selective for CB$_1$. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. |
| AM-4054 | | 2.2 | | CB$_1$ (40×) | | A potent but slow-onset agonist. |
| AM-4056 | | 0.041 | | | 6.51 | Another name for HU-243, it is a potent agonist at both the CB$_1$ and CB$_2$ receptors. |
| AM-4113 | | | | CB$_1$ | | A CB$_1$ selective neutral antagonist. |
| AM-6545 | | | | CB$_1$ | 4.06 | A peripherally selective silent antagonist of CB$_1$ receptors. |
| AM-7438 | | | | | | A potent agonist of CB$_1$ and CB$_2$ with reduced duration of action. |
| AM-11245 | | | | | | |