OpenLLM-France/wikimedia huggingface dataset:
# Serine protease HTRA2, mitochondrial

Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in caspase-dependent apoptosis and in Parkinson's disease.

## Structure
### Gene

The gene HTRA2 encodes a serine protease. The human gene has 8 exons and locates at chromosome band 2p12.

### Protein

Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, mitochondrial is 49kDa in size and composed of 458 amino acids. The peptide fragment of 1-31 amino acid is the mitochondrial transition sequence, fragment 32-133 amino acid is propertied, and 134-458 is the mature protein Serine protease HTRA2, mitochondrial, and its theoretical pI of this protein is 6.12. HtrA2 shows similarities with DegS, a bacterial protease present in the periplasm of gram-negative bacteria. Structurally, HtrA2 is a trimeric molecule with central protease domains and a carboxy-terminal PDZ domain, which is characteristic of the HtrA family. The PDZ domain preferentially binds C-terminus of the protein substrate and modulate the proteolytic activity of the trypsin-like protease domain.

## Function

The high-temperature requirement (HtrA) family are conserved evolutionarily and these oligomeric serine proteases has been classified in family S1B of the PA protease clan in the MEROPS protease database. The protease activity of the HtrA member HtrA2/Omi is required for mitochondrial homeostasis in mice and humans and inactivating mutations associated with neurodegenerative disorders such as Parkinson's disease. Moreover, HtrA2/Omi is released in the cytosol from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by inhibitor of apoptosis protein (IAP) caspase inhibitors such as XIAP and CIAP1/2. Once bound, the serine protease cleaves the IAP, reducing the cell's inhibition to caspase activation. In summary, HTRA2/Omi contributes to apoptosis through both caspase-dependent and -independent pathways.

## Clinical significance

The members of the HtrA family of proteases have been shown playing critical roles in cell physiology and being involved in several pathological processes including cancer and neurodegenerative disease. Strong evidences supported HtrA2's involvement in oncogenesis. This protein is widely expressed in a variety of cancer cell lines, Analysis of biopsy samples showed changes in expression of HtrA2 in cancer tissues compared with normal tissues.
HtrA2 has recently been identified as a gene related to Parkinson's disease. Mutations in Htra2 have been found in patients with Parkinson's disease. Additionally, mice lacking HtrA2 have a parkinsonian phenotype. This suggests that HtrA2 is linked to Parkinson's disease progression in humans and mice.

## Interactions

HtrA serine peptidase 2 has been shown to interact with MAPK14, XIAP and BIRC2.
# Živalji

Živalji (Cyrillic: Живаљи) is a village in the municipality of Kakanj, Bosnia and Herzegovina.

## Demographics

According to the 2013 census, its population was 159, all Bosniaks.
# Travis Moran

Travis Moran (born (1985-08-16)16 August 1985) is a former Australian male volleyball player. He was part of the Australia men's national volleyball team. He competed with the national team at the 2004 Summer Olympics in Athens, Greece. He played with Australian Institute of Sport in 2004.

## Clubs

* Australian Institute of Sport (2004)
# Jeanne Sauvé Catholic School

Jeanne Sauvé Catholic School is a French-language immersion elementary school in Stratford, Ontario Canada. It is part of the Huron-Perth Catholic District School Board. It has been called "truly outstanding" by David Johnson, Professor of Economics at Wilfrid Laurier University in his 2005 study "Ontario's Best Public Schools: An Update to Signposts of Success". The school is named after Jeanne Sauvé, Canada's first woman to serve as both Governor General and Speaker of the House.

## History

The building was first home to St. Michael Catholic Secondary School and functioned as a high school from September of 1986 to September of 1993. The building was renamed and became an elementary school that year, graduating its first cohort in the summer of 1994. Since it was a high school, the school had a larger gym than typical for an elementary school. Due to increased enrolment, the gym was reduced and the performance stage was converted into a classroom in July of 2014.

## Notable alumni

* Alonzo Holt
* Justin Bieber Attended from first grade through third grade.
# Megamind (character)

Megamind is the titular main protagonist of the DreamWorks Animation franchise of the same name.
# Gary Putland

Gary Putland (born 10 February 1986) is an Australian professional cricketer. He is a left-arm fast-medium bowler who has played for the Southern Redbacks, the representative team of the South Australian Cricket Association.
Putland represented Australia at youth level and was trained at the Australian Cricket Academy. He played grade cricket for Southern Districts. He started playing limited overs and Twenty20 matches for South Australia in the 2005–06 season, but it took him until February 2010 to make his first-class debut for the state, in a Sheffield Shield match against Western Australia. He entered the players auction to join the Indian Premier League in 2011, but was unsold.
# Daniel Iffla

Daniel Iffla (1825–1907), known as Osiris, was a financier and philanthropist.

## Biography

Born into a Jewish family of Moroccan origin in Bordeaux, France, he made his fortune in Paris in the bank of Jules Mirès [fr] and Moïse Polydore Millaud. It invested in the Spanish railways, which earned him the Order of Isabella.
He devoted himself to philanthropy after the death of his wife Leonie Carlier, a year after she gave birth to two children.
His obsession with philanthropy emerged from the Jewish tradition of the tzedakah (charity), republican values and the irrepressible desire to spread his wealth. He built a statue in honor of Joan of Arc in Nancy, and an impressive collection of Napoleonic relics, bequeathed to the Pasteur Institute.
Disapproving of the conduct of his nieces, one of which was the mistress of Claude Debussy, he bequeathed his fortune to the Pasteur Institute (which used it in part for the creation of the Radium Institute) as well as assorted other charitable institutions.
Iffla built several synagogues in Paris, including the Buffault Synagogue, at Arcachon, one in Tours, and also the Vincennes Synagogue, as well as synagogues in Tunis and Lausanne. In the latter city, he also constructed a statue of William Tell (in gratitude to the Swiss for their reception of the army of Bourbaki in 1871).
His grave in Paris is made of white marble surmounted by a large bronze reproduction of Michelangelo's statue Moses, from the church San Pietro in Vincoli, Rome.
# Toyota Opa

The Toyota Opa (Japanese: トヨタ・Opa (オーパ), Hepburn: Toyota Ōpa) is a compact car produced by Toyota. Its name derives from the exclamation for surprise in Portuguese.
It was introduced at the October 1999 Tokyo Motor Show as a prototype car, and was put into production in January 2000. It was the result of the V50 Vista Ardeo wagon modified into a 5-door hatchback. The transmission shifter was relocated from the floor between the front seats to a location on the lower portion of the dashboard, allowing passengers to walk to the rear area from either front seat. It was initially available with the 1.8-litre 1ZZ-FE engine. Later in August 2000, the Opa was offered to customers with the 2.0-litre 1AZ-FSE engine and a continuously variable transmission. In January 2001, the GPS navigation was offered as an option.
The Opa was exclusive to Toyopet Store locations as a larger companion to the Caldina station wagon. It was discontinued in August 2005.
* Rear view
* 2002 Toyota Opa
# Choi Youn-ok

Choi Youn-Ok (Korean: 최윤옥; Hanja: 崔允玉; born (1985-04-23)23 April 1985) is a retired South Korean female volleyball player. She was part of the South Korea women's national volleyball team.
She participated in the 2011 FIVB Volleyball Women's World Cup, and the 2015 FIVB Volleyball World Grand Prix.
# The Feral Generation

The Feral Generation is a British feature film written and directed by Welsh filmmaker Andrew Jones and starring Ray Panthaki and Brooke Kinsella in the leading roles. The film was shot in Swansea and Cardiff, South Wales in 2007 and was the first film to be produced by London-based production company Urban Way Productions Ltd. In June 2008, the film was awarded Best UK Feature Film at the Swansea Life Film Festival.

## Plot

In 2004, a Home Office survey revealed that there are 20 to 60 youngsters, aged 16 to 24, living rough in each inner city in the UK. They are responsible for vast levels of crime and in almost all cases they have come from broken homes and a history of abuse, both physical and sexual, most of the time inflicted on them by their parents. Nikki, 18, fled a sexually abusive homelife and a succession of foster families to live on the street. There she met Vincent, 24, the product of heroin-addicted parents. Together, they spend their days trying to survive the perils of living rough and supporting their drug addictions.

## Reviews

"So here’s my take on The Feral Generation. I think Andrew Jones has pulled off a genuinely objective, dispassionate study of an aspect of modern life about which it is very hard indeed to be either dispassionate or objective. The Feral Generation is not a film that casts judgements – we are left to do that for ourselves – but it simply documents in detail something which we normally only see briefly at a distance...This is terrific acting, this really is award-winning stuff.And it is helped by Jones' amazing dialogue which manages to be realistic and credible enough to fit in the mouths of these characters yet at the same time erudite enough to hold our attention and make us think about what is being said...
Frankly, some of the direction is astounding; there are some pauses in the interviews that seem to last forever and shots of the couple hugging and tearful which last even longer. This is incredibly assured and confident work for a young director on his second feature. The Feral Generation is a magnificent film, powerful but not preachy, serious but not sentimental. In terms of storytelling, it's simply masterful: stunning acting, excellent script, amazing direction, supremely competent on every technical level."
Review of The Feral Generation by film critic MJ Simpson.

## Awards
### Swansea Life Film Festival

| Year | Result | Award | Category/Recipient(s) |
| 2008 | Won | Best UK Feature Film | Best UK Feature Film for The Feral Generation |
# George L. Hollahan Jr.

George L. Hollahan Jr. (May 1, 1919 – August 1982) was an American politician. He served as a Democratic member of the Florida House of Representatives. He also served as a member for the 43rd and 44th district of the Florida Senate.

## Life and career

Hollahan was born in Pittsburgh, Pennsylvania. He attended Riverside Military Academy and the University of Miami. He served in the United States Navy during World War II.
In 1957, Hollahan was elected to the Florida House of Representatives, serving until 1963. In the same year, he was elected to represent the 43rd district of the Florida Senate. He served until 1965, when he was succeeded by Robert L. Shevin. In 1966, he was elected to represent the 44th district, serving until 1972.
Hollahan died in August 1982, at the age of 63.
# Linear settlement

A linear settlement is a (normally small to medium-sized) settlement or group of buildings that is formed in a long line. Many of these settlements are formed along a transport route, such as a road, river, or canal. Others form due to physical restrictions, such as coastlines, mountains, hills or valleys. Linear settlements may have no obvious centre.
In the case of settlements built along a route, the route predated the settlement, and then the settlement grew along the transport route. Often, it is only a single street with houses on either side of the road. Mileham, Norfolk, England is an example of this pattern. Later development may add side turnings and districts away from the original main street. Places such as Southport, England developed in this way.
A linear settlement is in contrast with ribbon development, which is the outward spread of an existing town along a main street, and with a nucleated settlement, which is a group of buildings clustered around a central point.
Particular types of linear settlements are linear village, chain village, street village (Polish: ulicówka; German: Straßendorf, Lithuanian: gatvinis kaimas, French: village-rue), and some others. Different countries have varying classifications of linear settlements.
Sułoszowa, Poland, is notable for its 9 km long, single main street and its thin strips of farm land, inhabited by 3500 people.

## Cities and city districts

Linear designs have also been proposed for new city and district development projects, such as Arturo Soria y Mata's linear city, Michael Graves and Peter Eisenman's linear city, Madrid's Ciudad Lineal district, and Saudi Arabia's The Line. Such designs have been criticized as expressing a simplistic understanding of the process of urban growth and ignoring the human factor in design, resulting in inefficiency and limited growth potential.
# Stefan Kisyov

Stefan Kisyov is a Bulgarian novelist, journalist, playwright and short story writer. Kisyov was born in Stara Zagora in 1963. He studied at Sofia and Plovdiv universities, and also at the Sorbonne in Paris. He has worked as an electrician at a tram depot, locksmith at a chemical factory, administrator at a Black Sea hotel, stage hand at the Stara Zagora Opera, waiter, newspaper journalist and in television. He lived in France and Switzerland. He is the author of books such as Jukebox, Not a Thing Anywhere, Don't Wake the Somnambulist, Your Name is Woman and A Waiter in the Boyana Residence. His award-winning novel, The Executioner was published in 2003. Stefan Kisyov lives in Havana.

## Works
### Stefan Kisyov's novels

* Juke-box (1996)
* Nothing Anywhere (2000)
* Don't Wake Up the Sleepwalker (2000)
* The Executioner, winner of the Vick Foundation's "Best Novel of 2004" Era (publisher)
* A Waiter at Boyana Residence (2004)
* Thy name is a woman (2007) Era (publisher)
* The Voyeur and the Tenant (2008) Era (publisher)
* The Mystery of the Knight Capulet (2011) Era (publisher)

### Short stories

Kisyov has written over 100 short stories in influential newspapers and magazines and many non-fictional pieces.

### Play

* Desperadoes (1999)
# Jorge Triana Tena

Jorge Triana Tena (born September 8, 1979) is a Mexican politician affiliated to the PAN. From 2015 to 2018 he served as a deputy representing the tenth federal electoral district of Mexico City in the LXIII Legislature of the Mexican Congress. He was re-elected to the Chamber of Deputies in 2021, representing Mexico City's seventeenth district for the PAN.

## Life

Triana was born in Mexico City and received his undergraduate degree in law from the Instituto Tecnológico Autónomo de México in 2001; he would also get a master's degree in public policy from the same institution.
In 1996, Triana joined the PAN and coordinated university students in the lead-up to the 1997 Mexico City mayoral elections. From 1999 to 2001, he was the coordinator general of the party's local Secretariat of Youth Action.
In 2000, he was the director general of social development, administering welfare programs in the borough of Miguel Hidalgo. He oversaw the borough's investment in the "Beacons of Learning" (Faros del Saber) program, which established a modern network of libraries in the city; three were opened in the borough during his time in the office. He also advanced in the PAN, serving as the coordinator of national relations for the national PAN Secretariat of Youth Action.
Voters elected Triana via proportional representation to the Chamber of Deputies for the LIX Legislature in 2003. He was the secretary of the Special Commission for State Reform and sat on the Youth and Sports and Federal District Commissions. He also represented the legislature as a whole before the Federal Electoral Institute and was a national councilor for the PAN between 2004 and 2007.
In 2006, Triana moved from San Lázaro to the Legislative Assembly of the Federal District in its IV Legislature. He was the vice coordinator of the PAN parliamentary group in that legislature and presided over the Commission of Political-Electoral Matters, in addition to sitting on three commissions and two committees. At the same time, he sat on the editorial board of the City section of the Reforma newspaper.
Between 2009 and 2011, he served as a federal metropolitan delegate to the Secretariat of Economy, and from 2011 to 2013, he headed the Unit of Federal Relations in SEGOB's Subsecretary of Government, where he handled relations between the federal government and states, cities, electoral bodies and political parties. At this time, he also became involved in City Manager Mexico Holding, of which he was director general between 2013 and 2015.
Voters in the tenth district returned Triana to San Lázaro in the 2015 elections, during which term he served as the president of the Commission for Rules and Parliamentary Practices and sat on the Government and Metropolitan Development Commissions.
# Ana Maria Gosling

Ana Maria Padão Gosling (born (1985-01-24)24 January 1985) is a Brazilian female volleyball player.
With her club Sollys Nestlé Osasco she competed at the 2011 FIVB Volleyball Women's Club World Championship and with Molico/Osasco at the 2014 FIVB Volleyball Women's Club World Championship.
# Charles V

Charles V may refer to:
* Charles V, Holy Roman Emperor (1500–1558)
* Charles V of Naples (1661–1700), better known as Charles II of Spain
* Charles V of France (1338–1380), called the Wise
* Charles V, Duke of Lorraine (1643–1690)
* Charles Egon V, Prince of Fürstenberg (1891–1973)
* Infante Carlos of Spain, Count of Molina (1788–1855), first Carlist pretender to the throne of Spain (as Charles V)
# St. Luke's Church, Brzeg

St. Luke's Church - a parish church belonging to the Lutheran Diocese of Katowice. The church is located in Brzeg, Opole Voivodeship in Poland.

## History

Formerly, the site was that of an Old Lutheran place of worship. In 1897, the beginning of the construction of the church began. The construction work only took six months. The church was ceremonially blessed on October 10, 1897, and took the summons of St. Luke the Evangelist. During World War I, 29 Old Lutherans died - a memorial plaque has been set made in remembrance of them, on the wall of the church. After 1945, Brzeg became part of the Western and Recovered Territories, becoming again part of Poland. Up until 1952, the parish did not have permanent parish priest. Every two weeks, Priest Karol Jadwiszczok celebrated the liturgy and services in the Holy Trinity Church (Kościół Świętej Trójcy in Polish). When authorities ordered the church's deconstruction, the Lutherans started celebrating their services at the then vandalised Old Lutheran St. Luke's Church. The first permanent parish priest was Priest Stanisław Żwak, which already as a student helped out Priest Karol Jadwiszczok. After ordination, he became the leader of the denomination's parish in Brzeg and Kłodzko. He lived in Lewin Brzeski. Since 1999, the parish has been served by Priest Marian Niemiec from Opole. As of 2014, the parish has its own parish priest.
# Britt Weerman

Britt Weerman (Dutch:; born 13 June 2003) is a Dutch track and field athlete who competes in the high jump.
She won the silver medal at the 2023 European Indoor Championships. Weerman was the 2021 European Under-20 champion and finished second at the World U20 Championships a year later. She is the Dutch record holder for the high jump both outdoors and indoors, and has won eight national titles.

## Early life and background

Britt Weerman was born on 13 June 2003 in Assen, Netherlands. Initially, she trained in gymnastics from the age of six to thirteen when cartilage damage in her elbow joint forced her to stop. As of 2022, she studied commercial economics at the Johan Cruyff Academy.

## Youth and junior career

In 2020, at age 16/17, Weerman won Dutch under-18 titles in the high jump both indoors and outdoors and also claimed her first national senior titles, both indoors and outdoors.
The following year, she earned the gold medal at the European U20 Championships held in Tallinn, Estonia with a jump of 1.88 m.
In July 2022, the 19-year-old set a Dutch national record of 1.95 m at a meeting in Ninove, Belgium, improving her personal best by 7 cm and beating Nadine Broersen's previous record by 1 cm. In August, she won silver at the World U20 Championships staged in Cali, Colombia, clearing 1.93 m to finish second behind Karmen Bruus and ahead of Angelina Topić. The same month, she placed fourth with the same height at the Munich 2022 European Championships, this time behind Topić who also jumped 1.93 m, securing the bronze medal on countback.

## Senior career

On 3 February 2023, Weerman broke by 3 cm Broersen's Dutch indoor record with a clearance of 1.96 m in Weinheim, Germany, her outright best. She equalled this achievement at the European Indoor Championships held in March in Istanbul to take the silver medal behind Yaroslava Mahuchikh. It was the first medal for a Dutch high jumper in almost 50 years, after Annemieke Bouma's bronze in 1975.

## Personal bests

* High jump – 1.95 m (6 ft 4+3⁄4 in) (Ninove 2022) NU20R NR
** High jump indoor – 1.96 m (6 ft 5 in) (Weinheim 2023) NR
** High jump indoor U20 – 1.92 m (6 ft 3+1⁄2 in) (Weinheim 2022) NU20R

## Competition results

All information from World Athletics profile.

### International competitions

Representing the  Netherlands :
| Year | Competition | Venue | Position | Event | Result | Notes |
| 2021 | European U20 Championships | Tallinn, Estonia | 1st | High jump | 1.88 m | =NU23R |
| 2022 | World U20 Championships | Cali, Colombia | 2nd | High jump | 1.93 m | NU20R |
| 2022 | European Championships | Munich, Germany | 4th | High jump | 1.93 m | |
| 2023 | European Indoor Championships | Istanbul, Turkey | 2nd | High jump | 1.96 m | =NR |
| 2025 | European Indoor Championships | Apeldoorn, Netherlands | 11th (q) | High jump | 1.85 m | |

### National titles

* Dutch Athletics Championships
** High jump: 2020, 2022, 2024
* Dutch Indoor Athletics Championships
** High jump indoor: 2020, 2021, 2022, 2023, 2025