# List of state highways in South Carolina

This is a List of state highways in South Carolina. These state highways are owned and maintained by the U.S. state of South Carolina, through the South Carolina Department of Transportation (SCDOT).

## List of primary routes

Since its establishment, there have been countless removals and reestablishment of highways in the state (check notes for current or last form count). Typically, it is that one highway wins favor over another, while the other highway is either absorbed or downgraded to a secondary road.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| SC 1 | — | — | Georgia state line southwest of Limehouse | SC 12 in West Columbia | 01922-01-011922 | 01928-01-011928 | |
| SC 2 | 3.940 | 6.341 | US 21/US 176/US 321 in Cayce | US 378 in West Columbia | 01922-01-011922 | current | |
| SC 3 | — | — | SC 50 in Columbia | NC 202 at the North Carolina state line near Nichols | 01922-01-011922 | 01928-01-011928 | First form |
| SC 3 | 96.310 | 154.996 | US 278 / Mill Pond Road in Grays | US 321 in Swansea | 01928-01-011928 | current | Second form |
| SC 4 | 54.430 | 87.597 | US 78 east of Aiken | US 21 / US 21 Bus. / US 601 Truck near Wilkinson Heights | 01922-01-011922 | current | |
| SC 5 | 51.719 | 83.234 | US 521 near Van Wyck | I-85 / SC 198 in Blacksburg | 01922-01-011922 | current | |
| SC 6 | 116.092 | 186.832 | US 76 in Ballentine | US 52 / SC 6 Truck / Main Street Extension in Moncks Corner | 01922-01-011922 | current | |
| SC 7 | — | — | Georgia state line southwest of Calhoun Falls | NC 51 at the North Carolina state line near Fort Mill | 01922-01-011922 | 01942-01-011942 | First form |
| SC 7 | 5.920 | 9.527 | US 17 in Charleston | US 52 / US 78 in North Charleston | 01956-01-011956 | current | Second form |
| SC 8 | — | — | SR 8 at the Georgia state line near Starr | US 29 at the North Carolina state line northeast of Blacksburg | 01922-01-011922 | 01927-01-011927 | First form |
| SC 8 | 44.030 | 70.859 | US 276 west of Cleveland | US 25 / SC 418 in Ware Place | 01928-01-011928 | current | Second form |
| SC 9 | 259.570 | 417.737 | SC 65 in Cherry Grove Beach | NC 9 at the North Carolina state line near Fingerville | 01922-01-011922 | current | |
| SC 10 | 22.790 | 36.677 | SC 28 northwest of McCormick | US 25 Bus. / US 178 / SC 34 in Greenwood | 01922-01-011922 | current | |
| SC 11 | 119.850 | 192.880 | I-85 southwest of Fair Play | SC 150 in Gaffney | 01922-01-011922 | current | |
| SC 12 | — | — | Georgia state line south of North Augusta | SC 2 in West Columbia | 01922-01-011922 | 01928-01-011928 | First form |
| SC 12 | — | — | SC 26 in Hancock | NC 25 at the North Carolina state line northeast of Hancock | 01929-01-011929 | 01938-01-011938 | Second form |
| SC 12 | 28.250 | 45.464 | US 1 in West Columbia | I-20 / US 601 south of Lugoff | 01940-01-011940 | current | Third form |
| SC 13 | — | — | SC 14 in Pickens | SC 2 in Easley | 01922-01-011922 | 01928-01-011928 | First form |
| SC 13 | — | — | SR 13 at the Georgia state line southwest of Westminster | Greenville | 01928-01-011928 | 01946-01-011946 | Second form |
| SC 14 | — | — | SC 15 in Anderson | NC 283 at the North Carolina state line near Rocky Bottom | 01922-01-011922 | 01937-01-011937 | First form |
| SC 14 | 59.240 | 95.338 | US 76 Bus. in Laurens | I-26 / Landrum Road in Landrum | 01942-01-011942 | current | Second form |
| SC 15 | — | — | SC 2 in Calhoun | SC 92 near Cross Anchor | 01922-01-011922 | 01935-01-011935 | |
| SC 16 | — | — | SC 2 in Columbia | NC 16 at the North Carolina state line northeast of Bowling Green | 01922-01-011922 | 01931-01-011931 | First form |
| SC 16 | — | — | SC 48 in Columbia | SC 12 in Columbia | 01939-01-011939 | 01948-01-011948 | Second form |
| SC 16 | 9.550 | 15.369 | SC 48 in Columbia | US 176 / Clement Road in Columbia | 01964-01-011964 | current | Third form |
| SC 17 | — | — | SR 17 at the Georgia state line southwest of Westminster | SC 2 in Seneca | 01922-01-011922 | 01928-01-011928 | |
| SC 18 | — | — | SC 20 in Abbeville | Georgia state line northwest of Long Creek | 01922-01-011922 | 01938-01-011938 | First form |
| SC 18 | 39.040 | 62.829 | US 176 / SC 18 Truck / SC 215 in Union | NC 18 at the North Carolina state line near Blacksburg | 01938-01-011938 | current | Second form |
| SC 19 | 28.750 | 46.269 | Savannah River Site south of New Ellenton | US 25 / SC 121 southwest of Trenton | 01922-01-011922 | current | |
| SC 20 | 53.210 | 85.633 | Washington Street / Trinity Street in Abbeville | McBee Avenue / River Street / Richardson Street in Greenville | 01922-01-011922 | current | |
| SC 21 | — | — | Georgia state line at North Augusta | North Carolina state line near Cleveland | 01922-01-011922 | 01928-01-011928 | |
| SC 22 | — | — | SC 21 in Greenwood | SC 97 in Great Falls | 01922-01-011922 | 01952-01-011952 | First form |
| SC 22 | 29.390 | 47.299 | US 501 near Cool Spring | US 17 / Kings Road west of Briarcliff Acres | 02001-01-012001 | current | Second form; projected to become part of I-73 |
| SC 23 | — | — | SC 3 in Pee Dee | NC 22 at the North Carolina state line near Dillon | 01922-01-011922 | 01928-01-011928 | First form |
| SC 23 | 47.060 | 75.736 | US 221 / SC 28 in Modoc | US 1 in Batesburg–Leesville | 01929-01-01c. 1929 | current | Second form |
| SC 24 | — | — | Georgia state line near Mountain Rest | US 78 east of Dorchester | 01922-01-011922 | 01938-01-011938 | First form |
| SC 24 | 30.660 | 49.342 | US 76 / US 123 / Oak Street in Westminster | US 29 Bus. / US 76 / US 178 / SC 28 Bus. / SC 81 in Anderson | 01938-01-011938 | current | Second form |
| SC 25 | — | — | SC 21 in Hodges | SC 20 in Donalds | 01922-01-011922 | 01929-01-011929 | |
| SC 26 | — | — | SC 40 north of Georgetown | North Carolina state line near Fort Mill | 01922-01-011922 | 01933-01-011933 | First form |
| SC 26 | — | — | US 301 in Orangeburg | US 1 in Lugoff | 01935-01-011935 | 01951-01-011951 | Second form |
| SC 27 | — | — | SC 19 / SC 21 in Trenton | SC 2 east of Dorchester | 01922-01-011922 | 01927-01-011927 | First form |
| SC 27 | 19.511 | 31.400 | SC 61 in Givhans | US 176 near Sandridge | 01929-01-01c. 1929 | current | Second form |
| SC 28 | 131.220 | 211.178 | SR 28 at the Georgia state line near Mountain RestSR 28 at the Georgia state line northwest of Beech Island | SR 28 at the Georgia state line near Clarks HillUS 278 / SC 125 in Beech Island | 01922-01-011922 | current | |
| SC 28Y | — | — | SC 72 southwest of Abbeville | SC 28 southwest of Abbeville | 01941-01-01c. 1941 | 01957-01-011957 | |
| SC 28Y | — | — | SC 28 in Yemassee | US 17/US 21 in Yemassee | 01938-01-011938 | 01947-01-011947 | |
| SC 29 | — | — | SC 21 in Travelers Rest | North Carolina state line near Cleveland | 01922-01-011922 | 01925-01-01c. 1925 | |
| SC 30 | — | — | Beaufort | North Carolina state line near McColl | 01922-01-011922 | 01933-01-011933 | First form |
| SC 30 | — | — | US 221 in Watts Mills | SC 92 near Cross Anchor | 01935-01-011935 | 01956-01-011956 | Second form |
| SC 30 | 3.050 | 4.908 | SC 171 in James Island | Lockwood Drive in Charleston | 01995-01-01c. 1995 | current | Third form; projected to become part of an extension of I-526 |
| SC 31 | — | — | — | Goose Creek | 01922-01-011922 | 01951-01-011951 | First form |
| SC 31 | — | — | SC 7 in Charleston | SC 642 in North Charleston | 01985-01-01c. 1985 | 01990-01-01c. 1990 | Second form |
| SC 31 | 28.097 | 45.218 | SC 707 near Socastee | SC 9 in Little River | 02002-01-01c. 2002 | current | Third form; projected to become part of I-74 |
| SC 32 | — | — | SC 30 near Henderson | SC 6 near Jacksonboro | 01922-01-011922 | 01925-01-01c. 1925 | |
| SC 32 | — | — | SC 30 in Gardens Corner | SC 6 in Jacksonboro | 01926-01-01c. 1926 | 01951-01-011951 | |
| SC 33 | 19.360 | 31.157 | US 301 / US 601 / SC 4 / Andrew Dibble Street in Orangeburg | SC 267 northwest of Lone Star | 01922-01-011922 | current | |
| SC 34 | 185.930 | 299.225 | US 25 Bus. / US 178 Bus. / SC 10 in Greenwood | US 301 / US 501 / SC 9 / SC 57 in Dillon | 01922-01-011922 | current | |
| SC 35 | — | — | SC 41 in Darlington | North Carolina state line near Pageland | 01922-01-011922 | 01938-01-011938 | First form |
| SC 35 | 5.630 | 9.061 | I-77 in Cayce | US 378 / Seminole Drive in Columbia | 01996-01-01c. 1996 | current | Second form |
| SC 36 | — | — | Near Ridgeland | US 21 in Rowesville | 01922-01-011922 | 01951-01-011951 | |
| SC 37 | 15.430 | 24.832 | US 278 north of Barnwell | SC 39 southwest of Springfield | 01922-01-011922 | current | |
| SC 38 | 43.694 | 70.319 | US 501 east of Sellers | NC 38 at the North Carolina state line near Bennettsville | 01922-01-011922 | current | |
| SC 39 | 100.889 | 162.365 | US 278 / Savannah Drive southwest of Williston | US 221 in Cold Point | 01922-01-011922 | current | |
| SC 40 | — | — | US 17 / US 78 / SC 2 in Charleston | North Carolina state line north of Loris | 01922-01-011922 | 01933-01-011933 | |
| SC 41 | — | — | SC 2 near Goose Creek | SC 50 near Cheraw at the North Carolina state line northeast of Lake View | 01922-01-011922 | 01928-01-011928 | First form |
| SC 41 | — | — | US 301 near New Zion | New Zion | 01935-01-01c. 1935 | 01938-01-011938 | Second form |
| SC 41 | 121.5 | 195.5 | US 17 / Dingle Road in Mount Pleasant | NC 41 at the North Carolina state line northeast of Lake View | 01938-01-011938 | current | Third form |
| SC 42 | — | — | SC 3 in Sumter | SC 34 in Bishopville | 01922-01-011922 | 01925-01-01c. 1925 | First form |
| SC 42 | — | — | SC 33 northeast of Cope | SC 4 in Orangeburg | 01937-01-011937 | 01947-01-011947 | Second form |
| SC 43 | — | — | SR 70 at the Georgia state line southwest of McCormick | US 1 / US 21 / SC 2 / SC 5 / SC 215 in West Columbia | 01923-01-011923 | 01952-01-011952 | |
| SC 44 | — | — | SC 41 west of Gourdin | SC 40 in Georgetown | 01922-01-011922 | 01928-01-011928 | |
| SC 44 | — | — | SC 261 in Sanders Corner | SC 30 in Mannville | 01928-01-01c. 1928 | 01947-01-011947 | |
| SC 45 | 76.060 | 122.407 | US 17 / South Pinckney Street in McClellanville | US 15 / US 176 in Wells | 01923-01-011923 | current | |
| SC 46 | — | — | SC 45 in Ferguson | SC 41 in Moncks Corner | 01923-01-01c. 1923 | 01939-01-011939 | First form |
| SC 46 | 17.330 | 27.890 | US 321 northwest of Hardeeville | US 278 / Waterford Drive east of Bluffton | 01939-01-011939 | current | Second form |
| SC 46Y | — | — | US 17 in Hardeeville | SC 46 in Hardeeville | 01939-01-01c. 1939 | 01942-01-01c. 1942 | |
| SC 47 | — | — | SC 40 in Green Sea | NC 21 at the North Carolina state line northeast of Lake View | 01923-01-01c. 1923 | 01925-01-01c. 1925 | First form |
| SC 47 | 5.740 | 9.238 | US 301 east of Oaks Crossroads | SC 6 / SC 47 Truck / SC 267 in Elloree | 01929-01-01c. 1929 | current | Second form |
| SC 48 | 28.980 | 46.639 | US 21 / US 76 / US 176 / US 321 in Columbia | US 601 in Wateree | 01930-01-011930 | current | |
| SC 49 | — | — | SC 26 / SC 40 in Georgetown | NC 30 at the North Carolina state line near Little River | 01929-01-01c. 1929 | 01935-01-011935 | First form |
| SC 49 | 79.516 | 127.969 | US 221 / Smith Road in Watts Mills | NC 49 at the North Carolina state line in Lake Wylie | 01938-01-011938 | current | Second form |
| SC 50 | — | — | SC 2 in Columbia | NC 50 at the North Carolina state line near Wallace | 01922-01-011922 | 01928-01-011928 | First form |
| SC 50 | — | — | US 21 / SC 5 in Rock Hill | Mill Street in Rock Hill | 01942-01-01c. 1942 | 01947-01-011947 | Second form |
| SC 51 | 70.65 | 113.70 | US 701 north of GeorgetownUS 21 north of Fort Mill | US 76 / Evans Street in FlorenceNC 51 at the North Carolina state line near Fort Mill | 01926-01-01c. 1926 | current | |
| SC 52 | — | — | SC 31 / SC 45 in St. Matthews | SC 3 near Eastover | 01926-01-01c. 1926 | 01935-01-011935 | |
| SC 53 | 11.900 | 19.151 | US 378 southwest of Shiloh | SC 403 in Hobbs Crossroads | 01926-01-01c. 1926 | current | |
| SC 54 | — | — | SC 3 in Sumter | SC 51 in Salem | 01926-01-01c. 1926 | 01951-01-011951 | |
| SC 55 | — | — | SC 21 near Greenwod | SC 24 in Friendship | 01926-01-01c. 1926 | 01929-01-011929 | First form |
| SC 55 | 20.990 | 33.780 | SC 5 near Kings Creek | SC 49 / SC 274 / Lake Wylie Road southwest of Lake Wylie | 01929-01-011929 | current | Second form |
| SC 56 | 67.300 | 108.309 | SC 39 near Chappells | US 176 on the Southern Shops–Valley Falls line | 01926-01-01c. 1926 | current | |
| SC 57 | 25.880 | 41.650 | SC 41 / SC 41 Alt. in Fork | Fairley Road at the North Carolina state line northeast of Minturn | 01929-01-01c. 1929 | current | |
| SC 58 | — | — | SC 163 west of Lake Wylie | North Carolina state line northwest of Lake Wylie | 01929-01-011929 | 01942-01-011942 | First form |
| SC 58 | 12.520 | 20.149 | SC 341 in South Lynchburg | US 301 / US 378 in Turbeville | 01940-01-011940 | current | Second form |
| SC 59 | — | — | SC 55 east of Clover | SC 58 / SC 163 near Lake Wylie | 01929-01-011929 | 01942-01-011942 | First form |
| SC 59 | 15.697 | 25.262 | I-85 / Lakeshore Drive southwest of Fair Play | US 76 / US 123 / SC 28 in Seneca | 01942-01-011942 | current | Second form |
| SC 60 | 5.160 | 8.304 | SC 6 / Bush River Road southwest of Irmo | US 176 on the St. Andrews–Columbia line | 01929-01-01c. 1929 | current | |
| SC 61 | 67.05 | 107.91 | SC 30 in Charleston | US 78 near Farrells Crossroads | 01923-01-011923 | current | |
| SC 62 | — | — | SC 6 in Red Top | SC 61 north of Johns Island | 01923-01-011923 | 01936-01-011936 | First form |
| SC 62 | — | — | US 76 / SC 2 near Ballentine | St. Andrews | 01940-01-011940 | 01947-01-011947 | Second form |
| SC 63 | 28.200 | 45.384 | US 278 / Hickory Hill Road in Varnville | SC 64 Bus. in Walterboro | 01924-01-01c. 1924 | current | |
| SC 64 | 73.730 | 118.657 | Dunbarton Boulevard / Technology Drive in Snelling | US 17 in Jacksonboro | 01926-01-01c. 1926 | current | |
| SC 64Y | — | — | SC 64 in Round O | North of Round O | 01939-01-01c. 1939 | 01942-01-01c. 1942 | |
| SC 65 | — | — | US 78 near Branchville | SC 61 in Cooks Crossroads | 01929-01-011929 | 01952-01-011952 | First form |
| SC 65 | 4.710 | 7.580 | US 17 in North Myrtle Beach | SC 9 in Cherry Grove Beach | 01981-01-011981 | current | Second form |
| SC 66 | 18.550 | 29.853 | SC 56 southwest of Joanna | SC 72 in Whitmire | 01933-01-011933 | current | |
| SC 67 | 15.460 | 24.880 | US 378 / Walker Road east of McCormick | US 25 / US 178 near Greenwood | 01934-01-011934 | current | |
| SC 68 | — | — | SC 381 near Clio | North Carolina state line northeast of Clio | 01935-01-01c. 1935 | 01938-01-011938 | First form |
| SC 68 | — | — | US 78 in Denmark | Voorhees College in Denmark | 01938-01-011938 | 01947-01-011947 | Second form |
| SC 68 | 15.330 | 24.671 | US 278 in Almeda | US 17 Alt. / US 17 Conn. / US 21 in Yemassee | 01965-01-011965 | current | Third form |
| SC 69 | — | — | SC 4 in Orangeburg | SC 31 in Cameron | 01935-01-01c. 1935 | 01938-01-011938 | First form |
| SC 69 | — | — | SC 546 southwest of Pelion | SC 6 in Swansea | 01939-01-011939 | 01947-01-011947 | Second form |
| SC 69 | — | — | US 17 in Atlantic Beach | US 17 in Cherry Grove Beach | 01977-01-011977 | 01981-01-011981 | Third form |
| SC 70 | 29.990 | 48.264 | US 278 / SC 64 in Barnwell | US 301 / US 601 northwest of Cordova | 01936-01-011936 | current | |
| SC 71 | 14.980 | 24.108 | SC 20 in Abbeville | SC 81 east of Lowndesville | 01926-01-01c. 1926 | current | |
| SC 72 | — | — | SC 7 southwest of Cross Hill | SC 10 in Waterloo | 01926-01-01c. 1926 | 01932-01-011932 | First form |
| SC 72 | — | — | SC 7 near Leeds | Leeds | 01940-01-011940 | 01942-01-011942 | Second form |
| SC 72 | 124.860 | 200.943 | SR 72 at the Georgia state line southwest of Calhoun Falls | SC 122 in Rock Hill | 01942-01-011942 | current | Third form |
| SC 73 | — | — | SC 7 in Fort Mill | SC 26 in Indian Land | 01926-01-01c. 1926 | 01928-01-011928 | |
| SC 73 | — | — | SC 38 in Brownsville | SC 9 in Dillon | 01932-01-011932 | 01939-01-011939 | |
| SC 73 | — | — | US 301 / US 501 in Latta | SC 57 near Fork | 01939-01-011939 | 01942-01-011942 | |
| SC 73 | — | — | SR 73 at the Georgia state line southwest of Allendale | SC 5 / SC 641 in Sycamore | 01942-01-011942 | 01947-01-011947 | |
| SC 73 | — | — | US 17 Bus. in Springmaid Beach | US 17 Bus. in Myrtle Beach | 01960-01-011960 | 02006-01-012006 | |
| SC 75 | 8.110 | 13.052 | SC 5 / SC 75 Truck / Riverside Road in Van Wyck | NC 75 at the North Carolina state line near Lesslie | 01938-01-011938 | current | |
| SC 77 | — | — | SC 9 in Hickson | NC 77 at the North Carolina state line near Wallace | 01938-01-011938 | 01961-01-011961 | First form |
| SC 77 | — | — | US 76 / US 378 in Columbia | I-20 on the Woodfield–Dentsville line | 01981-01-011981 | 01982-01-011982 | Second form; became part of I-77 |
| SC 79 | — | — | SC 6 in Denmark | Voorhees College in Denmark | 01935-01-01c. 1935 | 01938-01-011938 | First form |
| SC 79 | 9.340 | 15.031 | SC 9 / Brickyard Road near Bennettsville | NC 79 at the North Carolina state line near McColl | 01938-01-011938 | current | Second form |
| SC 80 | — | — | SC 181 in Fair Play | SC 18 in Anderson | 01937-01-011937 | 01962-01-011962 | First form |
| SC 80 | 5.620 | 9.045 | SC 14 / SC 101 Truck / Tandem Drive in Greer | US 29 / SC 290 Truck / Gary Armstrong Road in Greer | 02002-01-012002 | current | Second form |
| SC 81 | 80.890 | 130.180 | SC 28 near Lethia | SC 124 in Greenville | 01926-01-01c. 1926 | current | |
| SC 82 | — | — | SC 20 near Lethia | SC 81 in Starr | 01928-01-011928 | 01949-01-011949 | |
| SC 83 | 4.820 | 7.757 | SC 381 northeast of Clio | NC 83 at the North Carolina state line northeast of Clio | 01938-01-011938 | current | |
| SC 84 | — | — | US 276 in Caesars Head State Park at the North Carolina state line northwest of ClevelandSolomon Jones Road in Jones Gap State Park at the North Carolina state line northwest of Cleveland | Solomon Jones Road in Caesars Head State Park at the North Carolina northwest of ClevelandYMCA Camp Greenville in Jones Gap State Park northwest of Cleveland | 01935-01-01c. 1935 | 01947-01-011947 | |
| SC 85 | — | — | SC 8 / SC 81 near Piedmont | US 29 in Piedmont | 01937-01-011937 | 01938-01-011938 | |
| SC 85 | — | — | US 1 near McBee | NC 85 at the North Carolina state line near Chesterfield | 01938-01-011938 | 01961-01-011961 | |
| SC 86 | 12.090 | 19.457 | SC 8 / Sitton Road south of Easley | US 25 / Sandy Springs Road southeast of Golden Grove | 01938-01-011938 | current | |
| SC 87 | — | — | SC 13 in Central | SC 81 northwest of Aaron | 01940-01-011940 | 01947-01-011947 | |
| SC 88 | 14.350 | 23.094 | North Broad Street in Pendleton | SC 8 west of Piedmont | 01939-01-011939 | current | Signed to begin at SC 28 Bus. in Pendleton |
| SC 89 | — | — | SC 8 in Easley | SC 135 in Easley | 01940-01-011940 | 01947-01-011947 | |
| SC 90 | 23.110 | 37.192 | US 378 Truck / US 501 Bus. / US 701 Truck / SC 90 Truck in Red Hill | US 17 / Fairway Drive in Little River | 01929-01-011929 | current | |
| SC 91 | — | — | SC 92 in Monarch Mill | Black Highway northwest of York | 01923-01-011923 | 01956-01-011956 | |
| SC 92 | 16.460 | 26.490 | SC 101 in Gray Court | SC 49 southwest of Cross Anchor | 01926-01-01c. 1926 | current | |
| SC 93 | — | — | SC 97 northeast of Great Falls | NC 200 at the North Carolina state line near Lancaster | 01926-01-01c. 1926 | 01952-01-011952 | |
| SC 93 | 19.760 | 31.801 | US 76 / SC 28 in Clemson | US 123 in Easley | 01964-01-011964 | current | |
| SC 94 | — | — | SC 9 in Lake View | North Carolina state line northeast of Lake View | 01926-01-01c. 1926 | 01938-01-011938 | First form |
| SC 94 | — | — | SC 54 northwest of New Zion | SC 175 in Coopers | 01938-01-011938 | 01947-01-011947 | Second form |
| SC 95 | — | — | US 1 near McBee | NC 85 at the North Carolina state line near Chesterfield | 01926-01-01c. 1926 | 01938-01-011938 | First form |
| SC 95 | — | — | SC 9 in Little Rock | Fairley Road at the North Carolina state line east of Clio | 01939-01-011939 | 01952-01-011952 | Second form |
| SC 96 | — | — | US 1 / SC 9 in Cheraw | NC 80 at the North Carolina state line near Cheraw | 01926-01-011926 | 01933-01-011933 | First form |
| SC 96 | — | — | SC 9 northwest of Bennettsville | North Carolina state line north of Bennettsville | 01932-01-011932 | 01938-01-011938 | Second form |
| SC 96 | — | — | US 521 near LancasterSC 9 near Taxahaw | SC 906 near TaxahawSC 943 near Taxahaw | 01940-01-011940 | 01947-01-011947 | Third form |
| SC 97 | 89.800 | 144.519 | US 521 / US 601 in Camden | SC 5 in Kings Creek | 01926-01-01c. 1926 | current | |
| SC 98 | — | — | US 1 / SC 9 in Kollock | NC 77 at the North Carolina state line near Wallace | 01928-01-011928 | 01938-01-011938 | First form |
| SC 98 | — | — | SC 91 south of Robat | SC 18 near Pacolet | 01940-01-011940 | 01956-01-011956 | Second form |
| SC 99 | 9.220 | 14.838 | US 21 / SC 200 in Great Falls | SC 9 southeast of Richburg | 01936-01-011936 | current | |
| SC 100 | — | — | US 1 southwest of Cheraw | SC 9 west of Chesterfield | 01940-01-011940 | 01947-01-011947 | |
| SC 101 | 56.522 | 90.963 | US 76 / Neeley Ferry Road in Hickory Tavern | SC 11 / Highway 912 near Tigerville | 01928-01-011928 | current | |
| SC 102 | 25.550 | 41.119 | US 15 Bus. / US 15 Truck / Patrick Highway in North Hartsville | SC 9 in Chesterfield | 01936-01-011936 | current | |
| SC 103 | — | — | SC 114 southeast of Gaffney | North Carolina state line near Gaffney | 01937-01-011937 | 01947-01-011947 | |
| SC 104 | — | — | SC 43 in McCormick | SC 10 northeast of Troy | 01939-01-011939 | 01947-01-011947 | |
| SC 105 | 33.220 | 53.462 | SC 49 south of Robat | I-85 / Hyatt Street in Gaffney | 01940-01-011940 | current | |
| SC 106 | — | — | Kathwood | SC 391 northeast of Aiken | 01940-01-011940 | 01947-01-011947 | |
| SC 107 | 15.290 | 24.607 | SC 28 near Mountain Rest | NC 107 at the North Carolina state line near Salem | 01940-01-011940 | current | |
| SC 108 | — | — | SC 100 southwest of Cheraw | SC 9 in Cheraw | 01940-01-011940 | 01947-01-011947 | |
| SC 109 | 14.520 | 23.368 | SC 145 / Hartsville–Ruby Road in Campbell Crossroads | NC 109 at the North Carolina state line near Mount Croghan | 01935-01-01c. 1935 | current | |
| SC 110 | — | — | US 221 in Chesnee | NC 741 at the North Carolina state line near Chesnee | 01931-01-011931 | 01942-01-011942 | First form |
| SC 110 | 9.280 | 14.935 | US 29 in Cowpens | US 221 Alt. / SC 11 near Chesnee | 01942-01-011942 | current | Second form |
| SC 111 | — | — | US 29 in Gaffney | NC 18 at the North Carolina state line northeast of Gaffney | 01928-01-01c. 1928 | 01938-01-011938 | First form |
| SC 111 | — | — | SC 113 in Gilbert | SC 386 in Ridge Crossroads | 01940-01-011940 | 01947-01-011947 | Second form |
| SC 112 | — | — | SC 9 in New Prospect | US 221 / SC 110 in Chesnee | 01936-01-011936 | 01939-01-011939 | First form |
| SC 112 | — | — | SC 215 / SC 215 Alt. in Carlisle | SC 115 in Mean Crossroads | 01940-01-011940 | 01947-01-011947 | Second form |
| SC 113 | 13.610 | 21.903 | SC 394 / South Dixie Road west of Salley | US 178 / Calks Ferry Road in Fairview Crossroads | 01937-01-011937 | current | |
| SC 114 | 6.360 | 10.235 | SC 18 north of Bonham | SC 18 / Jerusalem Road northeast of Jonesville | 01939-01-011939 | current | |
| SC 115 | — | — | US 176 in West Springs | SC 9 in Jonesville | 01939-01-011939 | 01947-01-011947 | |
| SC 116 | — | — | US 1 in Leesville | SC 113 near Gilbert | 01940-01-011940 | 01947-01-011947 | |
| SC 116 | 3.400 | 5.472 | Laurel Bay Road / Joe Frazier Road in Laurel Bay | US 21 / Geiger Boulevard at Marine Corps Air Station Beaufort on the Burton–Beaufort line | 01961-01-011961 | current | |
| SC 117 | — | — | SC 605 near Orangeburg | SC 235 near Fort Motte | 01940-01-011940 | 01947-01-011947 | |
| SC 118 | — | — | US 1 near Camden | US 1 in Cassatt | 01940-01-011940 | 01947-01-011947 | First form |
| SC 118 | 13.180 | 21.211 | SC 19 Truck / SC 302 in Aiken | US 78 Truck / SC 4 / SC 302 east of Aiken | 01974-01-011974 | current | Second form; signed as a beltway around Aiken, but is only official on alignment shown |
| SC 119 | — | — | SC 11 northwest of Gaffney | North Carolina state line northeast of Chesnee | 01942-01-011942 | 01947-01-011947 | First form |
| SC 119 | 5.990 | 9.640 | SR 119 at the Georgia state line near Garnett | US 321 in Garnett | 01960-01-011960 | current | Second form |
| SC 120 | 17.390 | 27.986 | SC 261 in Pinewood | US 76 / US 378 in Sumter | 01942-01-011942 | current | |
| SC 121 | — | — | SC 27 in Aiken | SC 12 in West Columbia | 01926-01-01c. 1926 | 01928-01-011928 | First form |
| SC 121 | — | — | SC 362 northeast of Ehrhardt | SC 6 in Vance | 01929-01-011929 | 01964-01-011964 | Second form |
| SC 121 | 134.200 | 215.974 | US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 at the Georgia state line south of North Augusta | US 21 / SC 322 in Rock Hill | 01964-01-011964 | current | Third form; northern part of a multi-state highway that also exists in Florida and Georgia |
| SC 122 | — | — | SC 2 in Cayce | US 1 / US 21 / SC 2 / SC 5 / SC 43 / SC 215 in West Columbia | 01942-01-011942 | 01947-01-011947 | First form |
| SC 122 | 5.740 | 9.238 | SC 72 / South Elizabeth Lane in Rock Hill | Waterford Park Drive in Rock Hill | 01975-01-011975 | current | Second form |
| SC 123 | — | — | SC 13 near Madison | SC 183 near Madison | 01942-01-011942 | 01947-01-011947 | |
| SC 124 | — | — | US 1 / US 76 in Columbia | US in Dentsville | 01942-01-011942 | 01947-01-011947 | First form |
| SC 124 | 5.630 | 9.061 | US 123 north of Powdersville | South Main Street in Greenville | 01969-01-01c. 1969 | current | Second form |
| SC 125 | 56.212 | 90.464 | US 278 / US 301 in Allendale | US 25 Bus. / SC 125 Truck in North Augusta | 01936-01-011936 | current | |
| SC 126 | 4.200 | 6.759 | US 25 / SC 121 / Elizabeth Avenue in Belvedere | SC 421 in Clearwater | 01937-01-011937 | current | |
| SC 127 | — | — | SC 9 in White Stone | US 29 near Converse | 01942-01-011942 | 01947-01-011947 | First form |
| SC 127 | 3.620 | 5.826 | US 221 / US 221 Truck south of Laurens | US 76 / US 76 Bus. / US 221 Truck in Laurens | 01967-01-01c. 1967 | current | Second form; completely concurrent with US 221 Truck |
| SC 128 | — | — | SC 170 in Old House | SC 28 in Almeda | 01940-01-011940 | 01966-01-011966 | First form |
| SC 128 | 2.110 | 3.396 | SC 170 in Port Royal | US 21 in Port Royal | 02012-01-012012 | current | Second form |
| SC 129 | 4.970 | 7.998 | Falling Creek Road east of Wellford | US 29 / SC 292 / Locust Street in Lyman | 01962-01-011962 | current | |
| SC 130 | 30.072 | 48.396 | SC 59 in Seneca | NC 281 at the North Carolina state line near Salem | 01937-01-01c. 1937 | current | |
| SC 131 | — | — | US 76 / SC 13 / SC 24 in Seneca | SC 289 in Calhoun | 01937-01-01c. 1937 | 01947-01-011947 | |
| SC 132 | — | — | SC 13 in Greenville | US 25 Alt. north of Greenville | 01937-01-011937 | 01947-01-011947 | First form |
| SC 132 | — | — | US 321 near Chester | SC 72 / SC 72 Bus. / SC 121 SC 121 Bus. northeast of Chester | 01975-01-01c. 1975 | 01981-01-01c. 1981 | Second form |
| SC 133 | 20.540 | 33.056 | US 76 / US 123 / SC 28 in Clemson | SC 11 in Keowee-Toxaway State Park near Salem | 01937-01-011937 | current | |
| SC 134 | — | — | US 76 / SC 13 / SC 28 in Seneca | SC 183 northeast of West Union | 01938-01-011938 | 01947-01-011947 | |
| SC 135 | 20.920 | 33.667 | US 178 near Liberty | SC 9 south of Pumpkintown | 01939-01-011939 | current | |
| SC 136 | — | — | SC 133 in Calhoun | SC 13 in Calhoun | 01940-01-011940 | 01947-01-011947 | |
| SC 137 | 8.410 | 13.535 | SC 93 in Norris | SC 183 near Six Mile | 01940-01-011940 | current | |
| SC 138 | — | — | SC 182 near Oakway | US 76 / SC 13 in Westminster | 01940-01-011940 | 01947-01-011947 | |
| SC 139 | — | — | US 76 / SC 13 / SC 28 northeast of SenecaSC 133 near Calhoun | Oconee–Pickens county line northeast of SenecaSC 88 southeast of Central | 01940-01-011940 | 01953-01-011953 | |
| SC 140 | — | — | US 15 in Hartsville | Darlington–Chesterfield county line northwest of Hartsville | 01942-01-011942 | 01947-01-011947 | |
| SC 141 | — | — | US 76 near Horrell Hill | SC 262 near Horrell Hill | 01942-01-011942 | 01947-01-011947 | |
| SC 145 | — | — | SC 644 near Walterboro | US 15 near Walterboro | 01942-01-011942 | 01946-01-011946 | First form |
| SC 145 | 26.150 | 42.084 | US 1 near McBee | NC 145 at the North Carolina state line near Chesterfield | 01961-01-011961 | current | Second form |
| SC 146 | 33.447 | 53.828 | US 276 in Greenville | SC 56 in Cross Anchor | 01942-01-011942 | current | |
| SC 147 | — | — | US 1 in McBee | SC 151 in Pine Ridge | 01942-01-011942 | 01947-01-011947 | |
| SC 149 | — | — | SC 102 near Hartsville | US 15 north of Dovesville | 01942-01-011942 | 01947-01-011947 | |
| SC 150 | 33.580 | 54.042 | SC 56 near Glenn Springs | NC 150 at the North Carolina state line near Gaffney | 01940-01-011940 | current | |
| SC 151 | — | — | SC 15 in Anderson | SC 20 in Williamston | 01926-01-01c. 1926 | 01929-01-011929 | First form |
| SC 151 | 52.850 | 85.054 | US 52 Bus. / SC 34 in Darlington | US 601 / SC 151 Bus. in Pageland | 01938-01-011938 | current | Second form |
| SC 152 | — | — | SC 15 / SC 20 in Belton | SC 21 in Ware Place | 01926-01-011926 | 01929-01-011929 | First form |
| SC 152 | — | — | SC 121 east of Bowman | US 178 / SC 2 near Dorchester | 01937-01-011937 | 01947-01-011947 | Second form |
| SC 153 | — | — | SC 344 southwest of LucknowSC 341 near Lucknow | SC 348 in LucknowSC 151 west of Hartsville | 01940-01-011940 | 01947-01-011947 | First form |
| SC 153 | 11.510 | 18.524 | Brown Road / Old Cleveland Street north of Golden Grove | Saluda Dam Road northeast of Easley | 01974-01-011974 | current | Second form |
| SC 154 | 16.680 | 26.844 | US 76 / Mayes Open Road in Mayesville | US 15 in Bishopville | 01939-01-011939 | current | |
| SC 155 | — | — | SC 34 / SC 151 west of Darlington | Carolina Avenue / Floyds Road in Auburn | 01940-01-011940 | 01947-01-011947 | |
| SC 156 | — | — | Fields Bridge Road near Cypress Crossroads | SC 153 in Ashland | 01940-01-011940 | 01947-01-011947 | |
| SC 157 | — | — | SC 151 southwest of Angelus | Angelus | 01940-01-011940 | 01942-01-011942 | First form |
| SC 157 | 10.210 | 16.431 | SC 157 Truck / SC 341 / SC 341 Truck in Kershaw | SC 346 near Catarrh | 01942-01-011942 | current | Second form |
| SC 158 | — | — | Rimini | SC 260 in Jordan | 01940-01-011940 | 01947-01-011947 | |
| SC 159 | — | — | Sandy Grove Church Road in Cypress Crossroads | US 15 / SC 34 near Alcot | 01940-01-011940 | 01947-01-011947 | |
| SC 160 | 11.040 | 17.767 | NC 160 at the North Carolina state line northwest of Fort Mill | US 521 in Indian Land | 01942-01-011942 | current | |
| SC 161 | — | — | SC 16 in Eau Claire | US 176 / SC 19 in Union | 01923-01-011923 | 01928-01-011928 | First form |
| SC 161 | 28.910 | 46.526 | US 21 / Cel-River Road in Rock Hill | NC 161 at the North Carolina state line northeast of Clover | 01929-01-01c. 1929 | current | Second form |
| SC 162 | 13.540 | 21.791 | SC 174 in Adams Run | US 17 in Rantowles | 01942-01-011942 | current | |
| SC 163 | — | — | SC 16 in York | North Carolina state line in Lake Wylie | 01926-01-01c. 1926 | 01938-01-011938 | |
| SC 164 | 2.500 | 4.023 | SC 174 / Willtown Road near Hollywood | SC 162 in Hollywood | 01942-01-011942 | current | |
| SC 165 | 28.393 | 45.694 | Dead end on Yonges Island in Meggett | US 17 Alt. / US 17 Alt. Truck / Old Light Road in Summerville | 01940-01-011940 | current | |
| SC 166 | — | — | US 21 near Yemassee | US 17 near Hendersonville | 01942-01-011942 | 01947-01-011947 | |
| SC 167 | — | — | SC 11 northwest of Gaffney | North Carolina state line near Gaffney | 01942-01-011942 | 01947-01-011947 | |
| SC 169 | — | — | SC 170 north of Bluffton | Near Chelsea | 01940-01-011940 | 01946-01-011946 | |
| SC 170 | 49.010 | 78.874 | SR 25 at the Georgia state line southwest of Limehouse | U.S. Route 21 Bus. / Polk Street in Beaufort | 01931-01-011931 | current | |
| SC 171 | — | — | SC 261 in Greeleyville | US 521 in Bryans Crossroads | 01930-01-011930 | 01949-01-011949 | First form |
| SC 171 | 12.560 | 20.213 | Arctic Avenue in Folly Beach | SC 7 in Charleston | 01956-01-011956 | current | Second form |
| SC 171Y | — | — | SC 171 in Greeleyville | Holliman Road near Greeleyville | 01940-01-01c. 1940 | 01942-01-011942 | |
| SC 172 | — | — | US 17 / US 701 in Whitehall Terrace | Clements Ferry Road in Cainhoy | 01937-01-011937 | 01940-01-011940 | First form |
| SC 172 | 9.000 | 14.484 | US 178 near North | SC 6 near St. Matthews | 01940-01-011940 | current | Second form |
| SC 173 | — | — | SC 27 in Ridgeville | US 78 / SC 2 near Ridgeville | 01936-01-011936 | 01940-01-011940 | First form |
| SC 173 | 1.570 | 2.527 | SC 27 / School Street in Ridgeville | US 78 / Myers–Mayo Road near Ridgeville | 01940-01-011940 | current | Second form |
| SC 174 | 25.730 | 41.408 | Yacht Club Road / Dock Site Road in Edisto Beach | US 17 in Osborn | 01936-01-011936 | current | Signed to begin at Dock Site Road / Buoy Road in Edisto Beach |
| SC 175 | — | — | US 301 in SardiniaSumter–Williamsburg county line northwest of Kingstree | SC 54 northwest of SardiniaSC 38 southeast of Marion | 01928-01-011928 | 01952-01-011952 | |
| SC 177 | — | — | US 176 / US 221 in Spartanburg | NC 192 at the North Carolina state line near Fingerville | 01933-01-011933 | 01935-01-011935 | First form |
| SC 177 | — | — | US 176 near Newberry | US 76 / SC 2 east of Ballentine | 01936-01-011936 | 01951-01-011951 | Second form |
| SC 177 | 7.820 | 12.585 | SC 9 / Delta Plant Road in Wallace | NC 177 at the North Carolina state line near Wallace | 01961-01-011961 | current | Third form |
| SC 178 | — | — | US 17 near Moncks Corner | Berkeley–Charleston county line near Honey Hill | 01928-01-011928 | 01933-01-011933 | |
| SC 179 | — | — | US 52 near Moncks Corner | McClellanville | 01933-01-011933 | 01950-01-011950 | First form |
| SC 179 | 0.670 | 1.078 | US 17 / Graystone Boulevard in Little River | NC 179 at the North Carolina state line near Little River | 01980-01-011980 | current | Second form |
| SC 180 | — | — | US 29 in Blacksburg | North Carolina state line near Blacksburg | 01942-01-011942 | 01947-01-011947 | |
| SC 181 | — | — | West Pine Grove Road in Fair Play | US 76 / SC 13 / SC 28 in Seneca | 01923-01-011923 | 01942-01-011942 | First form |
| SC 181 | 6.430 | 10.348 | SR 181 at the Georgia state line southwest of Starr | SC 412 in Starr | 01942-01-011942 | current | Second form |
| SC 182 | 9.580 | 15.418 | SC 59 / SC 243 in Fair Play | SC 24 in Oakway | 01925-01-01c. 1925 | current | |
| SC 183 | 53.712 | 86.441 | US 76 / US 123 in Westminster | US 123 in Greenville | 01926-01-01c. 1926 | current | |
| SC 184 | 34.610 | 55.699 | SR 368 at the Georgia state line southwest of Iva | SC 252 Lower Shady Grove Road northwest of Ware Shoals | 01925-01-01c. 1925 | current | |
| SC 185 | 26.920 | 43.324 | US 178 southwest of Hodges | SC 28 southeast of Homeland Park | 01938-01-011938 | current | |
| SC 186 | 14.960 | 24.076 | SC 8 northeast of Pickens | US 276 in Slater-Marietta | 01939-01-011939 | current | |
| SC 187 | 30.334 | 48.818 | SC 184 southwest of Iva | US 76 / SC 28 south of Pendleton | 01940-01-011940 | current | |
| SC 188 | — | — | SC 184 east of Antreville | US 178 / SC 20 near Honea Path | 01940-01-011940 | 01947-01-011947 | First form |
| SC 188 | 8.250 | 13.277 | SC 28 / Bountyland Road northwest of Seneca | SC 183 northeast of Walhalla | 01971-01-011971 | current | Second form |
| SC 190 | — | — | SC 39 near Chappells | Old Cherokee Road near Silverstreet | 01941-01-01c. 1941 | 01947-01-011947 | |
| SC 191 | 21.930 | 35.293 | SC 421 / Howlandville Road in Warrenville | SC 121 / Hill Top Drive in Johnston | 01936-01-011936 | current | |
| SC 192 | — | — | US 76 / SC 2 near Newberry | US 76 / SC 2 north of Newberry | 01928-01-01c. 1928 | 01947-01-011947 | |
| SC 193 | 6.930 | 11.153 | SC 23 / Mt. Alpha Road in Ward | SC 121 / Gabe Road near Saluda | 01937-01-011937 | current | |
| SC 194 | 14.690 | 23.641 | US 178 Conn. / US 378 in Saluda | SC 391 near Stoney Hill | 01939-01-011939 | current | |
| SC 195 | — | — | SC 43 near Saluda | SC 194 northeast of Saluda | 01942-01-011942 | 01947-01-011947 | |
| SC 196 | — | — | SC 19 in Trenton | SC 23 southwest of Johnston | 01940-01-011940 | 01947-01-011947 | |
| SC 197 | — | — | SC 19 north of Johnston | US 178 near Saluda | 01940-01-011940 | 01947-01-011947 | |
| SC 198 | 2.660 | 4.281 | I-85 / SC 5 in Blacksburg | NC 198 at the North Carolina state line north of Blacksburg | 01940-01-011940 | current | |
| SC 199 | — | — | SC 19 near Aiken | US 1 near Aiken | 01940-01-011940 | 01947-01-011947 | |
| SC 200 | 42.780 | 68.848 | US 321 / SC 34 in Winnsboro | NC 200 at the North Carolina state line near Lancaster | 01938-01-011938 | current | |
| SC 201 | 12.550 | 20.197 | SC 20 north of Abbeville | SC 284 / Level Land Road near Antreville | 01939-01-011939 | current | |
| SC 202 | 4.520 | 7.274 | US 76 in Little Mountain | US 176 southeast of Pomaria | 01939-01-011939 | current | |
| SC 203 | 7.750 | 12.472 | SC 20 / Trinity Street in Abbeville | SC 185 southeast of Arborville | 01940-01-011940 | current | |
| SC 204 | — | — | US 78 near Reevesville | SC 152 northwest of Rosinville | 01940-01-011940 | 01947-01-011947 | |
| SC 205 | — | — | SC 391 in Prosperity | Lexington–Richland county line northeast of Chapin | 01940-01-011940 | 01947-01-011947 | |
| SC 206 | — | — | SC 525 in North Charleston | Yeamans Hall Club in Hanahan | 01940-01-011940 | 01947-01-011947 | |
| SC 207 | 9.168 | 14.754 | US 601 / SC 9 in Pageland | NC 207 at the North Carolina state line near Pageland | 01940-01-011940 | current | |
| SC 208 | — | — | Orangeburg–Dorchester county line west of Reevesville | SC 204 west of Reevesville | 01942-01-011942 | 01947-01-011947 | |
| SC 209 | — | — | US 21 in Lobeco | Witsell Road / Porches Hill Road in Dale | 01942-01-011942 | 01947-01-011947 | |
| SC 210 | — | — | US 301 in Orangeburg | US 21 / SC 2 in Sandy Run | 01936-01-011936 | 01950-01-011950 | First form |
| SC 210 | 28.580 | 45.995 | US 21 in Branchville | SC 6 in Vance | 01964-01-011964 | current | Second form |
| SC 211 | — | — | SC 21 in Travelers Rest | North Carolina state line in Caesars Head State Park near Cleveland | 01925-01-01c. 1925 | 01928-01-011928 | First form |
| SC 211 | — | — | North Carolina state line northwest of Fort Mill | US 521 in Indian Land | 01928-01-011928 | 01942-01-011942 | Second form |
| SC 211 | 27.380 | 44.064 | SC 150 northeast of Pacolet | SC 49 in Sharon | 01942-01-011942 | current | Third form |
| SC 212 | 5.670 | 9.125 | SC 64 northwest of Bells Crossroads | US 21 east of Williams | 01937-01-011937 | current | |
| SC 213 | 21.380 | 34.408 | US 176 / Parr Road near Peak | US 321 / US 321 Bus. / SC 34 southwest of Winnsboro Mills | 01939-01-011939 | current | |
| SC 214 | — | — | SC 280 in Port Royal | US 21 in Burton | 01940-01-011940 | 01947-01-011947 | |
| SC 215 | 96.330 | 155.028 | US 21 / US 321 in Columbia | SC 295 / SC 296 in Spartanburg | 01928-01-011928 | current | |
| SC 216 | — | — | US 21 northwest of Sheldon | US 21 in Sheldon | 01939-01-011939 | 01947-01-011947 | First form |
| SC 216 | 1.220 | 1.963 | Battleground Road at Kings Mountain National Military Park near Blacksburg | NC 216 at the North Carolina state line northeast of Blacksburg | 01960-01-011960 | current | Second form |
| SC 217 | 15.390 | 24.768 | SC 64 in Lodge | SC 61 northwest of Canadys | 01936-01-011936 | current | |
| SC 218 | — | — | US 21 / SC 5 northeast of Eau Claire | US 21 / SC 219 southwest of Winnsboro Mills | 01939-01-011939 | 01950-01-011950 | |
| SC 219 | 9.030 | 14.532 | US 76 / SC 34 in Newberry | US 176 northwest of Pomaria | 01937-01-011937 | current | |
| SC 220 | — | — | SC 605 near St. Matthews | SC 6 west of St. Matthews | 01940-01-011940 | 01947-01-011947 | |
| SC 222 | — | — | SC 22 southeast of Blair | SC 215 near Blair | 01938-01-011938 | 01947-01-011947 | |
| SC 223 | — | — | SC 22 near Mitford | Fairfield–Chester county line near Mitford | 01939-01-011939 | 01940-01-011940 | First form |
| SC 223 | 6.740 | 10.847 | SC 9 / SC 901 north of Richburg | US 21 / W.D. Hattie Lane in Landsford | 01940-01-011940 | current | Second form |
| SC 224 | — | — | SC 269 near Rion | SC 34 west of Longtown | 01940-01-011940 | 01947-01-011947 | |
| SC 225 | — | — | SC 39 near Ware Shoals | SC 39 in Cross Hill | 01940-01-011940 | 01947-01-011947 | First form |
| SC 225 | 5.900 | 9.495 | US 25 / US 178 near Greenwood | SC 72 Bus. / Calhoun Road west of Greenwood | 01973-01-011973 | current | Second form |
| SC 226 | — | — | US 21 in White Oak | Near White Oak | 01940-01-011940 | 01947-01-011947 | |
| SC 227 | — | — | US 21 in Adger | SC 704 northwest of Blackstock | 01940-01-011940 | 01947-01-011947 | |
| SC 228 | — | — | US 276 / SC 2 in Barksdale | US 221 near Ora | 01940-01-011940 | 01947-01-011947 | |
| SC 229 | — | — | SC 227 near Blackstock | SC 901 southwest of Mitford | 01942-01-011942 | 01947-01-011947 | |
| SC 230 | 20.730 | 33.362 | US 25 / SC 121 / SC 125 in North Augusta | SC 25 in West Store Crossroads | 01939-01-011939 | current | Signage and SCDOT reference indicates the southern terminus is at US 25 / SC 121 (Knox Avenue), also in North Augusta. |
| SC 231 | — | — | SC 430 northwest of Johnston | US 1 near Ridge Spring | 01940-01-011940 | 01947-01-011947 | |
| SC 232 | — | — | SC 397 southwest of Ridge Spring | SC 23 / SC 39 in Ridge Spring | 01940-01-011940 | 01947-01-011947 | |
| SC 233 | — | — | SC 231 near Ward | SC 193 near Ward | 01940-01-011940 | 01947-01-011947 | |
| SC 234 | — | — | SC 23 in Ward | SC 434 near Batesburg | 01940-01-011940 | 01947-01-011947 | |
| SC 235 | — | — | SC 6 / SC 210 near Wolfton | SC 267 in Fort Motte | 01940-01-011940 | 01947-01-011947 | |
| SC 236 | — | — | SC 117 near St. Matthews | SC 235 near St. Matthews | 01942-01-011942 | 01947-01-011947 | |
| SC 237 | — | — | SC 404 near Johnston | SC 19 in Johnston | 01942-01-011942 | 01947-01-011947 | |
| SC 238 | — | — | Aiken–Edgefield county line southeast of Ridge Spring | SC 23 / SC 39 in Ridge Spring | 01942-01-011942 | 01947-01-011947 | |
| SC 239 | — | — | SC 235 near Hammond Crossroads | US 21 / SC 2 southwest of Hammond Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 240 | — | — | US 15 near Rosinville | US 178 / SC 2 southeast of Rosinville | 01944-01-01c. 1944 | 01947-01-011947 | |
| SC 241 | — | — | Edgefield–Greenwood county line south of Pittsburg | SC 246 south east of Ninety Six | 01942-01-011942 | 01947-01-011947 | |
| SC 242 | — | — | SC 243 near Fair Play | SC 24 / SC 181 near Oakway | 01940-01-011940 | 01947-01-011947 | |
| SC 243 | 8.380 | 13.486 | SC 59 / SC 182 in Fair Play | I-85 / SC 24 southeast of Townville | 01940-01-011940 | current | |
| SC 244 | — | — | SC 24 in Townville | US 76 / SC 13 / SC 28 in Seneca | 01940-01-011940 | 01947-01-011947 | |
| SC 245 | 5.060 | 8.143 | US 178 in Kneece | SC 391 / Lodestar Road north of Batesburg–Leesville | 01929-01-011929 | current | |
| SC 246 | 28.700 | 46.188 | US 178 in Friendship | US 178 in Hodges | 01929-01-011929 | current | |
| SC 247 | 10.700 | 17.220 | SC 20 / Breazeale Street in Belton | US 25 in Ware Place | 01929-01-011929 | current | |
| SC 248 | — | — | US 29 in Anderson | SC 20 in Williamston | 01929-01-011929 | 01935-01-011935 | First form |
| SC 248 | 6.170 | 9.930 | US 178 in Epworth | SC 34 / SC 246 in Ninety Six | 01940-01-011940 | current | Second form |
| SC 249 | — | — | SC 80 near Anderson | US 76 / US 178 / SC 28 | 01940-01-011940 | 01947-01-011947 | |
| SC 250 | — | — | US 25 in Donaldson | US 276 near Marietta | 01937-01-01c. 1937 | 01968-01-01c. 1968 | |
| SC 251 | — | — | US 25 near Cleveland | Mountain Page Road at the North Carolina state line northeast of Cleveland | 01937-01-01c. 1937 | 01947-01-011947 | |
| SC 252 | 35.711 | 57.471 | US 76 / US 178 southeast of Anderson | US 76 west of Laurens | 01938-01-011938 | current | |
| SC 253 | 19.656 | 31.633 | SC 124 in Parker | SC 414 / North Tigerville Road in Tigerville | 01939-01-011939 | current | |
| SC 254 | 8.230 | 13.245 | SC 72 Bus. in Greenwood | US 25 northwest of Cokesbury | 01940-01-011940 | current | |
| SC 255 | — | — | US 29 / SC 250 in Gantt | US 25 in Greenville | 01939-01-011939 | 01949-01-01c. 1949 | |
| SC 256 | — | — | US 178 / SC 20 in Donalds | SC 252 northwest of Ware Shoals | 01940-01-011940 | 01947-01-011947 | |
| SC 257 | — | — | SC 201 southwest of Due West | SC 284 nea Honea Path | 01942-01-011942 | 01956-01-011956 | Two instances: 1942 to 1947 and 1950 to 1956 |
| SC 258 | — | — | US 521 in Alcolu | Brogdon Road north of Alcolu | 01940-01-011940 | 01947-01-011947 | |
| SC 259 | — | — | US 25 northwest of Bath | US 1 / US 78 west of Aiken | 01942-01-011942 | 01947-01-011947 | |
| SC 260 | 12.520 | 20.149 | Santee Dam in Eagle Point | SC 261 in Manning | 01939-01-011939 | current | |
| SC 261 | 116.960 | 188.229 | US 701 in Yauhannah | US 521 south of Camden | 01923-01-011923 | current | |
| SC 262 | 14.750 | 23.738 | US 76 / US 378 / Veterans Road in Columbia | US 601 / Westvaco Road in Leesburg | 01938-01-011938 | current | |
| SC 263 | 5.250 | 8.449 | SC 764 in Eastover | US 76 / US 378 near Eastover | 01937-01-011937 | current | |
| SC 264 | — | — | SC 26 near Fort Motte | Lone Star Road in Lone Star | 01939-01-011939 | 01940-01-011940 | First form |
| SC 264 | — | — | US 321 in Bowling Green | SC 557 west of Lake Wylie | 01940-01-011940 | 01947-01-011947 | Second form |
| SC 265 | 24.690 | 39.735 | US 601 near Kershaw | SC 9 southeast of Ruby | 01926-01-011926 | current | |
| SC 266 | — | — | SC 260 west of Bloomville | Great Savannah Church Road southeast of Jordan | 01939-01-011939 | 01947-01-011947 | |
| SC 267 | 23.200 | 37.337 | US 15 near Santee | US 601 / Adams Road near Wiles Crossroads | 01940-01-011940 | current | |
| SC 268 | 5.630 | 9.061 | SC 265 / Steen Road southwest of Ruby | SC 9 / SC 109 in Mount Croghan | 01940-01-011940 | current | |
| SC 269 | 11.950 | 19.232 | SC 215 west of Blythewood | US 321 south of Winnsboro Mills | 01942-01-011942 | current | |
| SC 270 | — | — | US 1 in Blaney | SC 213 near Blaney | 01942-01-011942 | 01947-01-011947 | |
| SC 271 | — | — | US 76 northwest of Westminster | SC 288 in Salem | 01942-01-011942 | 01971-01-011971 | |
| SC 272 | — | — | SC 185 west of Due West | SC 256 in Donalds | 01942-01-011942 | 01947-01-011947 | |
| SC 273 | — | — | SC 96 in Tradesville | SC 207 south of Wolf Pond Cross Roads | 01942-01-011942 | 01947-01-011947 | |
| SC 274 | 17.537 | 28.223 | NC 274 at the North Carolina state line northwest of Lake Wylie | SC 322 in Rock Hill | 01938-01-011938 | current | |
| SC 275 | — | — | SC 905 in Red Bluff Crossroads | SC 9 in Loris | 01942-01-011942 | 01947-01-011947 | |
| SC 277 | — | — | SC 215 southwest of Blythewood | SC 218 southwest of Blythewood | 01942-01-011942 | 01947-01-011947 | First form |
| SC 277 | 8.140 | 13.100 | US 76 in Columbia | I-77 in Dentsville | 01976-01-011976 | current | Second form |
| SC 278 | — | — | Southeast of Chappells | SC 19 near Chappells | 01942-01-011942 | 01947-01-011947 | |
| SC 279 | — | — | SC 154 near St. Charles | SC 34 southeast of Antioch | 01942-01-011942 | 01947-01-011947 | |
| SC 280 | — | — | SC 281 / Parris Island access road in Port Royal | US 21 in Burton | 01929-01-01c. 1929 | 02012-01-012012 | |
| SC 281 | — | — | SC 28 near Ellenton | SC 37 in Barnwell | 01925-01-01c. 1925 | 01926-01-011926 | First form |
| SC 281 | 3.190 | 5.134 | US 21 in Port Royal | US 21 Bus. in Beaufort | 01928-01-01c. 1928 | current | Second form |
| SC 282 | — | — | SC 28 northwest of Millett | SC 28 northeast of Millett | 01939-01-011939 | 01947-01-011947 | |
| SC 283 | 17.840 | 28.711 | US 221 / SC 28 / Collier Street in Plum Branch | US 25 northwest of Edgefield | 01939-01-011939 | current | |
| SC 284 | — | — | SC 81 / Tom Young Bridge Road southeast of Lowndesville | SC 28 / SC 184 east of Antreville | 01928-01-011928 | 01932-01-011932 | First form |
| SC 284 | 19.590 | 31.527 | SC 81 / Tom Young Bridge Road southeast of Lowndesville | SC 28 / SC 184 east of Antreville | 01940-01-011940 | current | Second form |
| SC 285 | — | — | US 21 / SC 281 in Beaufort | Hunting Island | 01939-01-011939 | 01954-01-011954 | |
| SC 286 | — | — | SC 367 southwest of Early Branch | SC 32 northeast of Sheldon | 01940-01-011940 | 01947-01-011947 | |
| SC 287 | — | — | SC 82 in Mount Carmel | SC 432 near Troy | 01940-01-011940 | 01947-01-011947 | |
| SC 288 | 15.260 | 24.559 | US 178 / SC 11 near Sunset | US 276 in Slater-Marietta | 01940-01-011940 | current | |
| SC 289 | — | — | US 76 / SC 28 in Calhoun | Clemson College in Calhoun | 01940-01-011940 | 01947-01-011947 | |
| SC 290 | 30.582 | 49.217 | US 25 east of Slater-Marietta | US 221 in Moore | 01937-01-01c. 1937 | current | |
| SC 291 | 11.400 | 18.347 | US 25 / White Horse Road Extension in Gantt | SC 253 east of Sans Souci | 01939-01-011939 | current | Signed to end at US 276 / SC 253 in Sans Souci |
| SC 292 | 13.640 | 21.951 | SC 290 in Duncan | SC 9 northwest of Boiling Springs | 01939-01-011939 | current | |
| SC 293 | — | — | US 29 northeast of Blacksburg | Battleground Road northeast of Blacksburg | 01940-01-011940 | 01947-01-011947 | |
| SC 294 | — | — | US 29 in Golden Grove | US 25 southeast of Gantt | 01940-01-011940 | 01947-01-011947 | |
| SC 295 | 16.700 | 26.876 | US 176 / SC 9 west of Pacolet | I-85 Bus. / New Cut Road in Southern Shops | 01940-01-011940 | current | |
| SC 296 | 21.803 | 35.089 | SC 14 in Five Forks | US 29 in Spartanburg | 01940-01-011940 | current | |
| SC 297 | — | — | US 76 / US 178 east of Anderson | US 29 near Anderson | 01942-01-011942 | 01947-01-011947 | |
| SC 298 | — | — | Cherokee Falls | US 29 southwest of Blacksburg | 01942-01-011942 | 01947-01-011947 | |
| SC 299 | — | — | US 29 in SpartanburgSouth Green River Road near Macedonia | SC 110 north of CowpensSC 11 in Gaffney | 01942-01-011942 | 01947-01-011947 | |
| SC 300 | 11.460 | 18.443 | US 278 south of Barnwell | US 301 in Ulmer | 01940-01-011940 | current | |
| SC 301 | — | — | SC 30 northeast of Salkehatchie | SC 6 / SC 64 southwest of Ruffin | 01926-01-01c. 1926 | 01928-01-011928 | First form |
| SC 301 | — | — | US 76 in Timmonsville | SC 30 in Lees Crossroads | 01928-01-011928 | 01932-01-011932 | Second form |
| SC 302 | — | — | SC 763 in Oswego | US 15 Alt. in Dubose Crossroads | 01929-01-011929 | 01947-01-011947 | First form |
| SC 302 | 66.200 | 106.539 | SC 125 south of Spiderweb | US 21 / US 176 / US 321 in West Columbia | 01973-01-011973 | current | Second form |
| SC 303 | 13.515 | 21.750 | US 17 near Green Pond | US 17 Alt. / SC 63 in Walterboro | 01929-01-011929 | current | |
| SC 304 | 5.880 | 9.463 | Main Street in Hilda | US 78 Bus. in Blackville | 01939-01-011939 | current | |
| SC 305 | — | — | US 76 / US 301 in Florence | Fore Road northeast of Florence | 01939-01-011939 | 01947-01-011947 | |
| SC 306 | — | — | Moses Dingle Road in Davis Station | US 301 northeast of Summerton | 01939-01-011939 | 01947-01-011947 | |
| SC 307 | — | — | SC 3 north of Allendale | SC 508 southwest of Ulmer | 01942-01-011942 | 01947-01-011947 | |
| SC 308 | 10.990 | 17.687 | US 221 in Ora | SC 56 Bus. / SC 72 Bus. in Clinton | 01940-01-011940 | current | |
| SC 309 | — | — | SC 341 northwest of Lake City | SC 53 / SC 53 Alt. in Hobbs Crossroads | 01940-01-011940 | 01968-01-011968 | |
| SC 310 | 8.500 | 13.679 | US 176 / SC 453 Truck in Holly Hill | SC 6 near Vance | 01939-01-011939 | current | |
| SC 311 | 9.250 | 14.886 | US 176 in Sandridge | SC 6 near Cross | 01926-01-01c. 1926 | current | |
| SC 312 | — | — | SC 3 in Kline | SC 300 near Kline | 01942-01-011942 | 01947-01-011947 | |
| SC 313 | — | — | SC 39 northeast of Williston | SC 390 near Williston | 01942-01-011942 | 01947-01-011947 | |
| SC 314 | 2.610 | 4.200 | US 15 west of Holly Hill | US 176 northwest of Holly Hill | 01938-01-011938 | current | |
| SC 315 | — | — | SC 4 near Wilkinson Heights | SC 47 in Elloree | 01940-01-011940 | 01947-01-011947 | First form |
| SC 315 | 6.067 | 9.764 | US 17 near Levy | SC 170 near Levy | 02013-01-012013 | current | Second form |
| SC 316 | — | — | SC 315 west of Elloree | SC 33 near Creston | 01942-01-011942 | 01947-01-011947 | |
| SC 317 | — | — | Lexington–Calhoun county line near Gaston | US 21 / SC 2 northwest of Sandy Run | 01942-01-011942 | 01947-01-011947 | First form |
| SC 317 | — | — | US 501 in Myrtle Beach | US 17 northeast of Myrtle Beach | 01975-01-011975 | 01981-01-011981 | Second form |
| SC 318 | — | — | SC 233 west of Ward | SC 193 northwest of Ward | 01942-01-011942 | 01947-01-011947 | |
| SC 319 | 13.210 | 21.259 | US 701 in Homewood | US 501 / St. John Road in Aynor | 01951-01-011951 | current | |
| SC 320 | — | — | SC 303 in Green Pond | SC 32 in Green Pond | 01933-01-011933 | 01947-01-011947 | |
| SC 321 | — | — | SC 32 in Green Pond | US 17 in Walterboro | 01926-01-01c. 1926 | 01929-01-011929 | |
| SC 322 | 28.050 | 45.142 | SC 49 near Pinckneyville | US 21 in Rock Hill | 01936-01-011936 | current | |
| SC 323 | — | — | Bennetts Point | SC 32 near Green Pond | 01940-01-011940 | 01947-01-011947 | |
| SC 324 | 13.880 | 22.338 | SC 5 Bus. / SC 161 Bus. in York | SC 72 / SC 121 near Rock Hill | 01940-01-011940 | current | |
| SC 325 | — | — | SC 907 northwest of Chester | US 321 / SC 909 in Lowrys | 01942-01-011942 | 01947-01-011947 | |
| SC 326 | — | — | South of Jacksonboro | US 17 in Jacksonboro | 01942-01-011942 | 01947-01-011947 | |
| SC 327 | 22.623 | 36.408 | US 52 / US 301 in Effingham | I-95 northeast of Quinby | 01942-01-011942 | current | |
| SC 328 | — | — | Dan Sexton Road southeast of Sharon | US 321 south of York | 01942-01-011942 | 01947-01-011947 | |
| SC 329 | — | — | SC 177 near Peak | SC 22 near Glymphville | 01942-01-011942 | 01947-01-011947 | First form |
| SC 329 | 6.350 | 10.219 | SC 105 / McKown's Mountain Road southeast of Gaffney | SC 18 northeast of East Gaffney | 01982-01-011982 | current | Second form |
| SC 330 | — | — | SC 5 northeast of Ulmer | SC 641 near Ehrhardt | 01942-01-011942 | 01947-01-011947 | |
| SC 331 | — | — | SR 73 at the Georgia state line southwest of Allendale | SC 5 in Sycamore | 01926-01-01c. 1926 | 01942-01-011942 | First form |
| SC 331 | — | — | SC 631 southwest of Barton | SC 361 west of Barton | 01942-01-011942 | — | Second form |
| SC 332 | 18.070 | 29.081 | SC 4 east of Springfield | US 301 / US 601 southeast of Cope | 01929-01-01c. 1929 | current | |
| SC 333 | 3.340 | 5.375 | US 321 / Daley Road in Scotia | US 601 / Town Hall Avenue in Furman | 01939-01-011939 | current | |
| SC 334 | — | — | SC 64 southeast of Barnwell | SC 36 / SC 364 in Ehrhardt | 01940-01-011940 | 01947-01-011947 | |
| SC 335 | — | — | SC 361 east of Barton | SC 361 near Miley | 01939-01-011939 | 01947-01-011947 | |
| SC 336 | 13.590 | 21.871 | US 321 / Sand Hills Road in Tillman | SC 462 in Old House | 01939-01-011939 | current | |
| SC 337 | — | — | SC 631 near Barton | SC 28 in Allendale | 01940-01-011940 | 01947-01-011947 | |
| SC 338 | — | — | SC 28 in Brunson | SC 335 northeast of Brunson | 01940-01-011940 | 01947-01-011947 | |
| SC 339 | — | — | SC 5 in Tarboro | SC 336 in Ridgeland | 01940-01-011940 | 01947-01-011947 | |
| SC 340 | 10.990 | 17.687 | SC 403 near Timmonsville | SC 34 / SC 151 in Darlington | 01940-01-011940 | current | |
| SC 341 | 93.870 | 151.069 | SC 41 / SC 51 in Johnsonville | US 521 Bus. / US 601 in Kershaw | 01923-01-011923 | current | |
| SC 342 | — | — | SC 155 in Lewis Crossroads | SC 34 / SC 340 in Darlington | 01940-01-011940 | 01947-01-011947 | |
| SC 343 | — | — | SC 305 in Florence | SC 34 in Mechanicsville | 01940-01-011940 | 01947-01-011947 | |
| SC 344 | — | — | SC 34 near Camden | SC 34 northwest of Bishopville | 01940-01-011940 | 01947-01-011947 | |
| SC 345 | — | — | SC 34 west of Dillon | North Carolina state line northeast of Little Rock | 01940-01-011940 | 01947-01-011947 | |
| SC 346 | 12.580 | 20.246 | SC 341 in Bethune | SC 903 / Holley Road near Catarrh | 01940-01-011940 | current | |
| SC 347 | — | — | Sumter–Lee county line southeast of Mayesville | SC 763 in Elliott | 01940-01-011940 | 01942-01-011942 | |
| SC 348 | — | — | SC 344 in Zemp | Lucknow Road in Lucknow | 01940-01-011940 | 01947-01-011947 | |
| SC 349 | — | — | SC 34 near Lees Crossroads | SC 151 southeast of Hartsville | 01942-01-011942 | 01947-01-011947 | |
| SC 350 | — | — | US 178 in Black | US 25 near Ware Shoals | 01942-01-011942 | 01947-01-011947 | |
| SC 351 | — | — | SC 34 in Lydia | SC 35 in Hartsville | 01923-01-011923 | 01925-01-01c. 1925 | First form |
| SC 351 | — | — | SC 9 northwest of Richburg | US 21 east of Lowrys | 01942-01-011942 | 01947-01-011947 | Second form |
| SC 352 | — | — | SC 34 in Antioch | SC 34 near Antioch | 01942-01-011942 | 01947-01-011947 | |
| SC 353 | — | — | US 521 in Shamokin | SC 341 near Mount Pisgah | 01942-01-011942 | 01947-01-011947 | |
| SC 354 | — | — | SC 260 southeast of Lakewood | US 521 west of Brogdon | 01942-01-011942 | 01947-01-011947 | |
| SC 355 | — | — | US 176 in Buffalo | SC 115 northwest of Buffalo | 01942-01-011942 | 01947-01-011947 | |
| SC 356 | — | — | SC 34 northeast of Bingham | SC 9 near Manning Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 357 | 15.040 | 24.205 | SC 101 / SC 290 in Greer | US 176 in Campobello | 01950-01-011950 | current | |
| SC 358 | 3.330 | 5.359 | SC 357 northwest of Lyman | SC 129 / SC 292 in Lyman | 01950-01-011950 | current | |
| SC 359 | — | — | SC 334 in Govan | US 78 in Bamberg | 01942-01-011942 | 01947-01-011947 | |
| SC 360 | — | — | SC 36 near Rowesville | SC 42 southwest of Orangeburg | 01942-01-011942 | 01947-01-011947 | |
| SC 361 | — | — | SC 337 near Barton | SC 63 near Miley | 01936-01-011936 | 01947-01-011947 | |
| SC 362 | 23.060 | 37.111 | SC 212 in Williams | US 78 in Bamberg | 01939-01-011939 | current | |
| SC 363 | 13.270 | 21.356 | US 321 north of Luray | SC 63 northeast of Varnville | 01940-01-011940 | current | |
| SC 364 | — | — | SC 330 near Ehrhardt | SC 362 near Lodge | 01940-01-011940 | 01947-01-011947 | |
| SC 365 | — | — | SC 128 in Horsegall | SC 28 northwest of Cummings | 01940-01-011940 | 01947-01-011947 | |
| SC 366 | — | — | SC 367 northwest of Gillisonville | US 17 in Coosawhatchie | 01940-01-011940 | 01947-01-011947 | |
| SC 367 | — | — | SC 369 northeast of Robertville | US 17 Alt. in Yemassee | 01940-01-011940 | 01947-01-011947 | |
| SC 368 | — | — | US 17 in Switzerland | SC 170 near Coosawhatchie | 01940-01-011940 | 01947-01-011947 | |
| SC 369 | — | — | SC 5 in Robertville | SC 374 near Pineland | 01946-01-01c. 1946 | 01947-01-011947 | |
| SC 370 | — | — | SC 3 north of Blackville | SC 37 near Springfield | 01942-01-011942 | 01947-01-011947 | |
| SC 371 | — | — | SC 70 in Barnwell | Ashleigh Road near Ashleigh | 01942-01-011942 | 01947-01-011947 | |
| SC 372 | — | — | SC 194 southwest of Stoney Hill | Saluda River southwest of Stoney Hill | 01942-01-011942 | 01947-01-011947 | |
| SC 373 | — | — | SC 39 near Snelling | SC 70 near Snelling | 01942-01-011942 | 01947-01-011947 | |
| SC 374 | — | — | SC 367 northeast of Pineland | Jasper–Hampton county line near Pineland | 01946-01-01c. 1946 | 01947-01-011947 | |
| SC 375 | 9.330 | 15.015 | SC 377 near Lane | US 521 in Greeleyville | 01949-01-011949 | current | |
| SC 376 | — | — | SC 763 in Sumter | US 76 / US 521 in Sumter | 01942-01-011942 | 01947-01-011947 | |
| SC 377 | 14.560 | 23.432 | SC 375 near Lane | SC 261 in Kingstree | 01949-01-011949 | current | |
| SC 380 | — | — | US 501 near Sellers | SC 38 west of Latta | 01942-01-011942 | 01952-01-011952 | |
| SC 381 | 22.700 | 36.532 | SC 38 in Blenheim | NC 381 at the North Carolina state line near Boykin | 01929-01-011929 | current | |
| SC 382 | — | — | SC 38 near Drake | SC 38 in Bennettsville | 01940-01-011940 | 01947-01-011947 | |
| SC 383 | — | — | SC 9 northwest of Bennettsville | SC 38 near Bennettsville | 01936-01-01c. 1936 | 01970-01-011970 | |
| SC 384 | — | — | SC 79 in Breeden | North Carolina state line southeast of Fletcher | 01939-01-011939 | 01947-01-011947 | |
| SC 385 | — | — | SC 341 near Bishopville | US 15 / SC 34 in Una | 01942-01-011942 | 01947-01-011947 | First form |
| SC 385 | 11.730 | 18.878 | US 15 / US 401 southwest of Bennettsville | SC 79 near Boykin | 01970-01-011970 | current | Second form |
| SC 386 | — | — | Saluda–Lexington county line north of Leesville | SC 43 northeast of Leesville | 01942-01-011942 | 01947-01-011947 | |
| SC 387 | — | — | SC 38 in Monroe Crossroads | SC 381 in Five Forks | 01942-01-011942 | 01947-01-011947 | |
| SC 388 | — | — | SC 34 near Brownsville | SC 38 in Bristow | 01942-01-011942 | 01947-01-011947 | |
| SC 389 | 13.730 | 22.096 | US 321 in Neeses | SC 39 in Perry | 01942-01-011942 | current | |
| SC 390 | — | — | SC 64 in Snelling | SC 394 west of Salley | 01939-01-011939 | 01947-01-011947 | |
| SC 391 | 34.920 | 56.198 | SC 39 in Jones Crossroads | US 76 in Prosperity | 01923-01-011923 | current | |
| SC 392 | 3.620 | 5.826 | US 1 near Ridge Spring | SC 23 / SC 39 in Ridge Spring | 01926-01-01c. 1926 | current | |
| SC 393 | — | — | SC 39 in Perry | SC 1 near Woodford | 01926-01-01c. 1926 | 01947-01-011947 | |
| SC 394 | 22.370 | 36.001 | SC 4 near Windsor | US 178 west of North | 01932-01-011932 | current | |
| SC 395 | 15.140 | 24.365 | SC 194 northeast of Saluda | SC 121 in Newberry | 01939-01-011939 | current | |
| SC 396 | — | — | SC 39 in Mountville | Jefferson Davis Road northeast of White Plains Crossroads | 01940-01-011940 | 01947-01-011947 | |
| SC 397 | — | — | Aiken–Edgefield county line near Ridge Spring | Padgett Pond Road near Monetta | 01940-01-011940 | 01947-01-011947 | |
| SC 398 | — | — | SC 39 southeast of Saluda | US 178 near Saluda | 01942-01-011942 | 01947-01-011947 | |
| SC 399 | — | — | SC 234 southeast of Saluda | US 178 east of Saluda | 01940-01-011940 | 01947-01-011947 | |
| SC 400 | 12.440 | 20.020 | US 321 / SC 332 in Norway | SC 4 in Edisto | 01942-01-011942 | current | |
| SC 401 | — | — | SC 40 in Mount Pleasant | Isle of Palms | 01929-01-01c. 1929 | 01933-01-011933 | First form |
| SC 401 | — | — | SC 215 in Monticello | SC 22 northwest of Monticello | 01942-01-011942 | 01947-01-011947 | Second form |
| SC 402 | 15.680 | 25.235 | Unnamed access road to US 17 Alt. / US 52 / Turnaround Court northeast of Moncks Corner | SC 41 / Steed Creek Road in Huger | 01929-01-01c. 1929 | current | According to SCDOT, the access road is part of SC 402, but it is not signed as such. |
| SC 403 | 36.480 | 58.709 | SC 341 in Camp Branch | US 15 / SC 34 in Lees Crossroads | 01933-01-011933 | current | |
| SC 404 | — | — | SC 191 near Johnston | SC 231 south of Ward | 01942-01-011942 | 01947-01-011947 | |
| SC 405 | — | — | US 15 south of Hartsville | SC 151 in Flinns Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 406 | — | — | Shelton | SC 215 northeast of Shelton | 01942-01-011942 | 01947-01-011947 | |
| SC 407 | — | — | SC 403 near Sparrows Crossroads | US 52 / US 301 near Bannockburn | 01942-01-011942 | 01947-01-011947 | |
| SC 408 | — | — | Clarendon–Williamsburg county line near Lake City | SC 54 / SC 341 in Lake City | 01942-01-011942 | 01947-01-011947 | |
| SC 409 | — | — | US 221 / SC 72 in Greenwood | SC 225 in Isle of Pines | 01942-01-011942 | 01947-01-011947 | |
| SC 410 | — | — | US 178 / SC 2 in Bowman | SC 4 near Cameron | 01942-01-011942 | 01947-01-011947 | First form |
| SC 410 | 17.460 | 28.099 | US 701 in Baxter Forks | NC 410 at the North Carolina state line northeast of Jernigans Crossroads | 01952-01-011952 | current | Second form |
| SC 411 | — | — | SC 41 in Kingstree | SC 38 near Marion | 01924-01-011924 | 01928-01-011928 | First form |
| SC 411 | — | — | SC 391 near Delmar | Near Acapulco | 01942-01-011942 | 01947-01-011947 | Second form |
| SC 412 | — | — | SC 44 southeast of Salters | SC 441 in Kingstree | 01926-01-01c. 1926 | 01928-01-011928 | First form |
| SC 412 | 7.030 | 11.314 | US 29 in Holland Store | SC 81 / First Avenue in Starr | 01949-01-011949 | current | Second form |
| SC 413 | — | — | SC 41 near Moncks Corner | SC 511 in Jamestown | 01926-01-01c. 1926 | 01928-01-011928 | First form |
| SC 413 | 17.190 | 27.665 | SC 184 in Iva | US 76 / US 178 / Rutledge Road southwest of Belton | 01949-01-011949 | current | Second form |
| SC 414 | — | — | SC 3 in Sumter | SC 41 in Darlington | 01923-01-011923 | 01928-01-011928 | First form |
| SC 414 | 17.260 | 27.777 | US 276 south of Slater-Marietta | SC 14 east of Highland | 01949-01-011949 | current | Second form |
| SC 415 | — | — | SC 101 in Greer | US 25 northwest of Locust Hill | 01949-01-011949 | 01964-01-011964 | |
| SC 416 | — | — | SC 8 in Pickens | US 29 in Greenville | 01949-01-011949 | 01956-01-011956 | |
| SC 417 | 21.699 | 34.921 | US 276 in Mauldin | SC 296 northeast of Reidville | 01949-01-011949 | current | |
| SC 418 | 24.740 | 39.815 | US 25 / SC 8 in Ware Place | SC 101 / SC 146 / Carlton Duvall Drive northwest of Woodruff | 01949-01-011949 | current | |
| SC 419 | — | — | SC 267 south of Fort Motte | SC 26 southeast of Fort Motte | 01950-01-011950 | 01952-01-011952 | First form |
| SC 419 | 6.510 | 10.477 | SC 267 southeast of Wiles Crossroads | Mosley Road / Fort Motte Road / Town Square Street in Fort Motte | 01952-01-011952 | current | Second form |
| SC 420 | 4.930 | 7.934 | US 178 / Old Shoals Junction Road in Shoals Junction | US 25 Bus. / SC 252 Truck / Honea Path Street in Ware Shoals | 01950-01-011950 | current | |
| SC 421 | 10.360 | 16.673 | US 1 / US 78 / US 278 southwest of Clearwater | US 1 / US 78 / Dyches Road in Aiken | 01951-01-011951 | current | |
| SC 430 | 11.740 | 18.894 | SC 23 / SC 23 Truck east of Edgefield | US 278 / Gold Mine Road near Saluda | 01939-01-011939 | current | |
| SC 431 | — | — | SC 43 north of Oak Grove | US 1 in West Columbia | 01940-01-011940 | 01947-01-011947 | |
| SC 432 | — | — | SC 28 in ParksvilleGreenwood–McCormick county line northwest of Troy | SC 10 in TroySC 28 northwest of Troy | 01940-01-011940 | 01947-01-011947 | |
| SC 433 | — | — | South Main Street in McCormick | SC 283 near Whitetown | 01940-01-011940 | 01947-01-011947 | |
| SC 434 | — | — | US 178 in Holston Crossroads | SC 43 near Delmar | 01940-01-011940 | 01947-01-011947 | |
| SC 435 | — | — | US 25 near Pleasant Lane | SC 43 northeast of Pleasant Lane | 01942-01-011942 | 01947-01-011947 | |
| SC 436 | — | — | US 25 / SC 430 in Edgefield | SC 19 near Saluda | 01942-01-011942 | 01947-01-011947 | |
| SC 438 | — | — | SC 43 southwest of McCormick | SC 28 in McCormick | 01942-01-011942 | 01947-01-011947 | |
| SC 439 | — | — | SC 43 southwest of McCormick | SC 28 in Plum Branch | 01942-01-011942 | 01947-01-011947 | |
| SC 440 | — | — | Rowe Drive near Summerton | SC 158 southeast of Summerton | 01942-01-011942 | 01947-01-011947 | |
| SC 441 | 26.280 | 42.294 | SC 763 / Lynam Road in Millwood | US 15 near Manville | 01940-01-011940 | current | |
| SC 442 | — | — | US 15 in Summerton | US 15 north of Summerton | 01942-01-011942 | 01947-01-011947 | |
| SC 443 | — | — | SC 526 southeast of Camden | SC 44 near Manville | 01942-01-011942 | 01947-01-011947 | |
| SC 444 | — | — | SC 39 east of Ware Shoals | US 221 in Maddens | 01942-01-011942 | 01947-01-011947 | |
| SC 445 | — | — | SC 43 in Saluda | SC 194 northeast of Saluda | 01942-01-011942 | 01947-01-011947 | |
| SC 450 | — | — | US 52 in St. Stephen | SC 45 near Swamp Fox | 01940-01-011940 | 01947-01-011947 | |
| SC 451 | — | — | US 52 in Bonneau | Near Russellville | 01942-01-011942 | 01947-01-011947 | |
| SC 452 | — | — | SC 28 in Plum Branch | SC 439 northwest of Plum Branch | 01942-01-011942 | 01947-01-011947 | |
| SC 453 | 14.930 | 24.028 | US 178 in Harleyville | SC 45 in Eutawville | 01942-01-011942 | current | |
| SC 460 | — | — | SC 462 east of Bluffton | Hilton Head Island ferry landing west of Hilton Head Island | 01943-01-011943 | 01947-01-011947 | First form |
| SC 460 | 12.473 | 20.073 | SC 160 northeast of Tega Cay | SC 160 in Fort Mill | 02012-01-012012 | current | Second form |
| SC 461 | — | — | US 17 / SC 170 in Limehouse | SC 46 near Levy | 01940-01-011940 | 01947-01-011947 | First form |
| SC 461 | 3.710 | 5.971 | SC 61 in Charleston | Bees Ferry Road in Charleston | 02011-01-012011 | current | Second form |
| SC 462 | 35.920 | 57.808 | US 321 in Robertville | SC 170 near Chelsea | 01942-01-011942 | current | |
| SC 463 | — | — | Myrtle Island | SC 46 in Brighton Beach | 01942-01-011942 | 01947-01-011947 | |
| SC 464 | — | — | SC 46 west of Bluffton | SC 462 near Bluffton | 01942-01-011942 | 01947-01-011947 | |
| SC 465 | — | — | Southeast of Pritchardville | SC 170 near Pritchardville | 01942-01-011942 | 01947-01-011947 | |
| SC 466 | — | — | US 521 near Camden | Kershaw–Sumter county line near Spring Hill | 01942-01-011942 | 01947-01-011947 | |
| SC 478 | — | — | SC 302 in Aiken | SC 421 in Aiken | 01974-01-011974 | 01987-01-011987 | |
| SC 490 | — | — | US 521 near Fort Mill | North Carolina state line northeast of Tega Cay | 01940-01-011940 | 01947-01-011947 | |
| SC 496 | 1.640 | 2.639 | SC 49 / SC 49 Truck in Union | SC 18 in Union | 01986-01-01c. 1986 | current | Unsigned |
| SC 500 | — | — | SC 333 in Furman | SC 5 south of Estill | 01942-01-011942 | 01947-01-011947 | |
| SC 501 | — | — | SC 9 / SC 50 in Cheraw | North Carolina state line near Cheraw | 01923-01-011923 | 01926-01-011926 | |
| SC 502 | — | — | SC 175 near Kingstree | US 701 near Kensington | 01940-01-011940 | 01947-01-011947 | |
| SC 503 | — | — | US 501 / US 501 Alt. in Myrtle Beach | US 501 south of Conway | 01940-01-011940 | 01949-01-011949 | |
| SC 504 | — | — | SC 5 in Roddey | US 521 east of Van Wyck | 01940-01-011940 | 01960-01-011960 | |
| SC 505 | — | — | SC 2 in Cayce | US 21 / SC 5 / SC 215 in West Columbia | 01940-01-011940 | 01947-01-011947 | |
| SC 506 | — | — | US 301 / US 501 southwest of Dillon | SC 9 / SC 34 in Dillon | 01940-01-011940 | 01947-01-011947 | |
| SC 507 | — | — | US 521 near Trio | SC 175 near Kingstree | 01940-01-011940 | 01947-01-011947 | |
| SC 508 | — | — | SC 331 in Allendale | SC 5 in Ulmer | 01940-01-011940 | 01947-01-011947 | |
| SC 510 | — | — | SC 90 in Pee Dee Crossroads | SC 917 northeast of Aynor | 01940-01-011940 | 01947-01-011947 | |
| SC 511 | — | — | US 17 / US 701 in Whitehall Terrace | Northeast of Outland | 01926-01-01c. 1926 | 01952-01-011952 | |
| SC 512 | 24.250 | 39.027 | US 52 in Cades | SC 513 near Hopewell | 01928-01-011928 | current | |
| SC 513 | 8.870 | 14.275 | SC 41 / SC 51 near Hopewell | SC 261 north of Carters Crossroads | 01940-01-011940 | current | |
| SC 514 | — | — | US 52 / US 301 south of Florence | US 52 northwest of Florence | 01940-01-011940 | 01947-01-011947 | |
| SC 515 | — | — | SC 261 in Lane | US 521 northwest of Sampit | 01939-01-011939 | 01947-01-011947 | |
| SC 516 | — | — | SC 5 north of Fairfax | SC 641 near Jennys | 01942-01-011942 | 01947-01-011947 | |
| SC 517 | — | — | SC 3 south of Springfield | SC 5 northwest of Denmark | 01942-01-011942 | 01947-01-011947 | First form |
| SC 517 | 3.840 | 6.180 | SC 703 / 14th Avenue in Isle of Palms | US 17 / Greystone Boulevard in Mount Pleasant | 01993-01-011993 | current | Second form |
| SC 518 | — | — | SC 54 east of ScrantonSC 403 in Oats | SC 51 southeast of EvergreenClaussen | 01940-01-011940 | 01947-01-011947 | |
| SC 519 | — | — | Remleys | SC 511 northeast of Cainhoy | 01940-01-011940 | 01947-01-011947 | |
| SC 520 | — | — | SC 64 in Chaparral Ranches | Cypress Gardens | 01936-01-011936 | 01947-01-011947 | |
| SC 522 | 29.620 | 47.669 | SC 97 in Liberty Hill | NC 522 at the North Carolina state line near Sapps Crossroads | 01936-01-011936 | current | |
| SC 523 | — | — | Kershaw–Lancaster county line near Liberty Hill | — | 01936-01-011936 | 01947-01-011947 | |
| SC 525 | — | — | US 17 / US 701 in Charleston | Charleston International Airport in North Charleston | 01937-01-011937 | 01947-01-011947 | |
| SC 526 | — | — | US 521 in Dalzell | US 521 near Camden | 01939-01-011939 | 01947-01-011947 | |
| SC 527 | 65.940 | 106.120 | SC 41 near Warsaw | SC 341 / Cooper Mill Road in Wisacky | 01939-01-011939 | current | |
| SC 528 | — | — | SC 511 near Jamestown | US 521 northeast of Sampit | 01939-01-011939 | 01950-01-011950 | |
| SC 529 | — | — | US 521 northwest of Heath Springs | US 521 in Lancaster | 01939-01-011939 | 01947-01-011947 | |
| SC 530 | — | — | SC 713 southeast of Hilda | SC 5 / SC 68 in Denmark | 01942-01-011942 | 01947-01-011947 | |
| SC 531 | — | — | US 52 / US 78 in North Charleston | SC 525 in North Charleston | 01942-01-011942 | 01947-01-011947 | |
| SC 532 | — | — | SC 5 / SC 18 northwest of Blacksburg | North Carolina state line near Blacksburg | 01942-01-011942 | 01947-01-011947 | |
| SC 533 | — | — | SC 901 in Edgemoor | SC 5 in Rowell | 01942-01-011942 | 01947-01-011947 | |
| SC 534 | — | — | US 21 near Blackstock | Aiken Creek Road near Blackstock | 01942-01-011942 | 01947-01-011947 | |
| SC 536 | — | — | SC 51 Alt. in Pamplico | Southeast of Pamplico | 01942-01-011942 | 01947-01-011947 | |
| SC 537 | — | — | SC 5 in Gifford | Two Sisters Ferry Road near Varnville | 01942-01-011942 | 01947-01-011947 | |
| SC 538 | — | — | SC 261 in Pinewood | SC 120 southwest of Privateer | 01942-01-011942 | 01947-01-011947 | |
| SC 541 | 10.660 | 17.156 | SC 341 east of Olanta | US 52 in Coward | 01940-01-011940 | current | |
| SC 542 | — | — | US 301 in Wilson Crossroads | SC 154 near East Sumter | 01942-01-011942 | 01947-01-011947 | |
| SC 543 | — | — | SC 54 west of Turbeville | SC 54 east of Turbeville | 01942-01-011942 | 01947-01-011947 | |
| SC 544 | 13.710 | 22.064 | US 378 Truck / US 501 Bus. / US 701 Truck / French Collins Road in Red Hill | US 17 Bus. near Surfside Beach | 01942-01-011942 | current | |
| SC 545 | — | — | SC 279 northeast of Spring Hill | US 15 southwest of Bishopville | 01942-01-011942 | 01947-01-011947 | |
| SC 546 | — | — | West of Thor | US 178 west of Woodford | 01942-01-011942 | 01947-01-011947 | |
| SC 547 | — | — | SC 92 north of Union | SC 9 southwest of Kelton | 01942-01-011942 | 01947-01-011947 | |
| SC 548 | — | — | SC 51 in Hemingway | Davis Road / East Lawrimore Road near Ard Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 550 | — | — | SC 5 in Rock Hill | East of India Hook | 01942-01-011942 | 01947-01-011947 | |
| SC 551 | — | — | Hamer | North Carolina state line near Hamer | 01942-01-011942 | 01947-01-011947 | |
| SC 552 | — | — | US 1 / SC 43 in LexingtonNear Chapin | Near LexingtonLexington–Newberry county line north of Chapin | 01942-01-011942 | 01947-01-011947 | |
| SC 553 | — | — | US 178 southwest of Woodford | SC 5 in Woodford | 01942-01-011942 | 01947-01-011947 | |
| SC 554 | — | — | US 21 / SC 901 south of Rock Hill | US 21 northeast of Rock Hill | 01942-01-011942 | 01948-01-011948 | |
| SC 555 | 14.900 | 23.979 | SC 12 in Columbia | US 21 east of Blythewood | 01942-01-011942 | current | |
| SC 556 | — | — | SC 55 near Kings Creek | Nimitz Road northeast of Smyrna | 01942-01-011942 | 01947-01-011947 | |
| SC 557 | 6.710 | 10.799 | SC 55 / Ole Cambridge Circle east of Clover | SC 49 / SC 274 west of Lake Wylie | 01942-01-011942 | current | |
| SC 560 | 14.200 | 22.853 | SC 39 in Cross Hill | US 76 / Line Road in Kinards | 01940-01-011940 | current | |
| SC 561 | — | — | SC 56 near Mudlick | Belfast Road northeast of Mudlick | 01940-01-011940 | 01947-01-011947 | |
| SC 562 | — | — | SC 56 south of ClintonLaurens–Union county line near Cross Keys | SC 72 near ClintonSC 92 in Cross Keys | 01942-01-011942 | 01947-01-011947 | |
| SC 563 | — | — | Spartanburg–Union county line west of Buffalo | US 176 west of Buffalo | 01942-01-011942 | 01947-01-011947 | |
| SC 571 | — | — | US 301 in Sellers | Marion–Dillon county line near Mullins | 01942-01-011942 | 01947-01-011947 | |
| SC 572 | — | — | SC 175 near Gresham | SC 175 near Marion | 01940-01-011940 | 01947-01-011947 | |
| SC 573 | — | — | SC 34 west of Dillon | SC 57 near Mullins | 01942-01-011942 | 01952-01-011952 | |
| SC 574 | — | — | Bethea ExtensionDillon–Marlboro county line near Minturn | SC 57 in FloydaleSC 9 southeast of Clio | 01942-01-011942 | 01947-01-011947 | |
| SC 575 | — | — | West of Marion | SC 57 in Gapway | 01942-01-011942 | 01947-01-011947 | |
| SC 576 | 3.090 | 4.973 | US 76 / Wahee Road west of Marion | US 501 Bus. / SC 41 Alt. near Marion | 01973-01-011973 | current | |
| SC 590 | — | — | SC 24 northwest of Oakway | SC 59 northeast of Oakway | 01942-01-011942 | 01947-01-011947 | |
| SC 601 | — | — | SC 43 northeast of Lexington | SC 6 north of Lexington | 01939-01-011939 | 01947-01-011947 | |
| SC 602 | 10.690 | 17.204 | SC 6 in Red Bank | Charleston Highway / 13th Street / D Avenue in West Columbia | 01940-01-011940 | current | |
| SC 603 | — | — | Southwest of Irmo | SC 6 southwest of Irmo | 01940-01-011940 | 01947-01-011947 | |
| SC 604 | — | — | SC 31 southeast of Cameron | SC 6 northwest of Elloree | 01942-01-011942 | 01947-01-011947 | |
| SC 605 | — | — | — | — | 01942-01-011942 | 01947-01-011947 | |
| SC 610 | — | — | Edenvale Road on Johns Island | US 17 in Red Top | 01939-01-011939 | 01946-01-011946 | |
| SC 611 | — | — | SC 64 near Cotton Hill | US 78 / SC 2 in Summerville | 01939-01-011939 | 01946-01-011946 | |
| SC 612 | — | — | SC 64 southwest of Moncks CornerWest of Santee Circle | Lions Beach north of Moncks CornerUS 52 / Millies Way Drive in Santee Circle | 01940-01-011940 | 01946-01-011946 | |
| SC 614 | — | — | SC 61 in Charleston | US 17 in Charleston | 01940-01-011940 | 01951-01-011951 | |
| SC 615 | — | — | Folly Beach | SC 700 in Charleston | 01940-01-011940 | 01956-01-011956 | |
| SC 616 | — | — | SC 615 in Charleston | Ft. Johnson Road / Tallwood Road in Charleston | 01942-01-011942 | 01947-01-011947 | |
| SC 617 | — | — | SC 82 northwest of McCormick | SC 28 northeast of Willington | 01942-01-011942 | 01947-01-011947 | |
| SC 630 | — | — | SC 63 in Islandton | SC 64 / SC 217 in Lodge | 01937-01-011937 | 01947-01-011947 | |
| SC 631 | — | — | SC 37 / SC 70 near Allendale | SC 128 in Grays | 01932-01-011932 | 01972-01-011972 | |
| SC 632 | — | — | SC 63 southeast of Crocketville | SC 361 near Brunson | 01939-01-011939 | 01947-01-011947 | |
| SC 633 | — | — | SC 63 southeast of Miley | SC 361 in Miley | 01940-01-011940 | 01947-01-011947 | |
| SC 635 | — | — | SC 631 west of Luray | SC 331 near Gifford | 01942-01-011942 | 01947-01-011947 | |
| SC 636 | — | — | SC 63 near Walterboro | SC 64 near Williams | 01942-01-011942 | 01947-01-011947 | |
| SC 637 | — | — | SC 633 in Moselle | SC 36 near Moselle | 01942-01-011942 | 01947-01-011947 | |
| SC 638 | — | — | Bentwood Road near Leesville | US 1 in Leesville | 01942-01-011942 | 01947-01-011947 | |
| SC 640 | — | — | SC 64 near Walterboro | SC 173 near Grover | 01939-01-011939 | 01947-01-011947 | |
| SC 641 | 21.560 | 34.697 | US 301 northeast of Allendale | SC 64 near Lodge | 01929-01-011929 | current | |
| SC 642 | 19.292 | 31.047 | US 17 Alt. / US 17 Alt. Truck southwest of Summerville | US 52 / US 78 in North Charleston | 01939-01-011939 | current | |
| SC 643 | — | — | SC 641 southwest of Ehrhardt | SC 334 northwest of Ehrhardt | 01940-01-011940 | 01946-01-011946 | |
| SC 644 | — | — | SC 64 northwest of Walterboro | US 21 south of Smoaks | 01940-01-011940 | 01946-01-011946 | |
| SC 645 | — | — | SC 63 near Islandton | SC 64 northwest of Bells Crossroads | 01940-01-011940 | 01946-01-011946 | |
| SC 646 | — | — | SC 28 northwest of Allendale | SC 64 in Snelling | 01942-01-011942 | 01946-01-011946 | |
| SC 647 | — | — | Near Jackson | SC 28 / SC 64 near Jackson | 01942-01-011942 | 01947-01-011947 | |
| SC 648 | — | — | SC 649 near Ellenton | SC 39 in Dunbarton | 01942-01-011942 | 01947-01-011947 | |
| SC 649 | — | — | West of Ellenton | SC 648 near Ellenton | 01942-01-011942 | 01947-01-011947 | |
| SC 650 | — | — | SC 64 / SC 65 southwest of Summerville | SC 61 in Cooks Crossroads | 01942-01-011942 | 01950-01-011950 | |
| SC 651 | 8.270 | 13.309 | US 17 Alt. in Cottageville | SC 61 near Cottageville | 01940-01-011940 | current | |
| SC 652 | 10.480 | 16.866 | US 601 in Pineland | US 278 near Ridgeland | 01942-01-011942 | current | |
| SC 654 | — | — | Allendale–Hampton county line near Lawtonville Crossroads | SC 631 in Lawtonville Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 660 | — | — | SC 279 near Ashwood | SC 341 / SC 527 in Wisacky | 01942-01-011942 | 01947-01-011947 | |
| SC 662 | — | — | SC 82 in Willington | SC 617 northeast of Willington | 01942-01-011942 | 01947-01-011947 | |
| SC 663 | — | — | US 501 near Rains | SC 571 near Rains | 01942-01-011942 | 01947-01-011947 | |
| SC 664 | — | — | SC 177 north of Newberry | US 176 north of Newberry | 01942-01-011942 | 01947-01-011947 | |
| SC 665 | — | — | US 21 / SC 5 near Columbia | SC 555 in Columbia | 01942-01-011942 | 01947-01-011947 | |
| SC 667 | — | — | SC 171 in Greeleyville | Bennett Branch Road / Easler Highway north of Greeleyville | 01942-01-011942 | 01947-01-011947 | |
| SC 668 | — | — | SC 6 west of Moncks Corner | Pinopolis | 01942-01-011942 | 01947-01-011947 | |
| SC 670 | — | — | SC 43 in McCormick | US 25 / US 178 near Greenwood | 01942-01-011942 | 01969-01-011969 | |
| SC 691 | — | — | SC 33 in Orangeburg | US 21 / SC 2 northwest of St. Matthews | 01938-01-011938 | 01947-01-011947 | |
| SC 692 | 9.100 | 14.645 | US 321 / West Fifth Street in Swansea | SC 172 near North | 01942-01-011942 | current | |
| SC 700 | 20.380 | 32.798 | Dead end in Rockville | US 17 in Charleston | 01940-01-011940 | current | |
| SC 702 | 18.950 | 30.497 | SC 246 near Ninety Six | SC 39 southeast of Big Creek | 01940-01-011940 | current | |
| SC 703 | 10.930 | 17.590 | US 17 in Mount Pleasant | Palm Avenue / 41st Avenue in Isle of Palms | 01933-01-011933 | current | |
| SC 704 | — | — | SC 215 north of Salem Crossroads | US 21 in Chester | 01939-01-011939 | 01947-01-011947 | |
| SC 705 | — | — | SC 66 near Renno | SC 7 near Renno | 01940-01-011940 | 01947-01-011947 | |
| SC 706 | — | — | US 76 / SC 2 in Jalapa | SC 7 in Whitmire | 01940-01-011940 | 01947-01-011947 | |
| SC 707 | — | — | SC 51 in Oatland | US 701 in Yauhannah | 01939-01-011939 | 01947-01-011947 | |
| SC 707 | 12.645 | 20.350 | US 17 Bus. in Murrells Inlet | US 17 / Farrow Parkway in Myrtle Beach | 01949-01-011949 | current | |
| SC 711 | — | — | US 17 west of Pawleys Island | North Causeway Road in Pawleys Island | 01939-01-011939 | 01947-01-011947 | |
| SC 712 | — | — | SC 41 in Lake View | SC 9 near Dillon | 01940-01-011940 | 01947-01-011947 | |
| SC 713 | — | — | SC 64 northeast of Olar | SC 70 in Hilda | 01942-01-011942 | 01947-01-011947 | |
| SC 714 | — | — | SC 70 in Barnwell | SC 304 south of Hilda | 01942-01-011942 | 01947-01-011947 | |
| SC 715 | — | — | SC 70 in Hilda | SC 304 in Hilda | 01942-01-011942 | 01947-01-011947 | |
| SC 716 | — | — | Cat Island ferry near North Santee | US 17 / US 701 in Georgetown | 01942-01-011942 | 01947-01-011947 | |
| SC 720 | — | — | SC 72 east of Calhoun Falls | SC 28 in Abbeville | 01942-01-011942 | 01947-01-011947 | |
| SC 721 | — | — | SC 72 in Calhoun Falls | SC 72 southwest of Abbeville | 01942-01-011942 | 01947-01-011947 | |
| SC 722 | — | — | SC 72 near Leeds | SC 9 near Gayle Mill | 01942-01-011942 | 01947-01-011947 | |
| SC 723 | — | — | SC 707 in Williams Hill | Near Woodbury | 01942-01-011942 | 01947-01-011947 | |
| SC 724 | — | — | US 701 in Green Sea | North Carolina state line north of Green Sea | 01942-01-011942 | 01947-01-011947 | |
| SC 725 | — | — | SC 160 in Indian Land | North Carolina state line near Indian Land | 01942-01-011942 | 01947-01-011947 | |
| SC 726 | — | — | SC 175 in Indiantown | Bartells Road in Bartell Crossroads | 01942-01-011942 | 01947-01-011947 | |
| SC 727 | — | — | SC 632 northwest of Crocketville | SC 361 northwest of Crocketville | 01942-01-011942 | 01947-01-011947 | |
| SC 730 | — | — | SC 43 in McCormick | SC 817 southeast of Troy | 01942-01-011942 | 01947-01-011947 | |
| SC 742 | 3.510 | 5.649 | SC 145 north of Chesterfield | NC 742 north of Chesterfield | 01942-01-011942 | current | |
| SC 752 | — | — | SC 381 in McColl | North Carolina state line east of McColl | 01942-01-011942 | 01947-01-011947 | |
| SC 760 | 1.182 | 1.902 | US 76 / US 76 Conn. / US 378 in Columbia | Crossing over Wildcat Creek at Fort Jackson in Columbia | 01939-01-011939 | current | |
| SC 761 | — | — | US 276 northwest of Laurens | SC 308 north of Watts Mills | 01940-01-011940 | 01947-01-011947 | |
| SC 762 | — | — | US 76 west of Clinton | SC 72 south of Clinton | 01940-01-011940 | 01947-01-011947 | |
| SC 763 | 13.950 | 22.450 | SC 261 in Wedgefield | US 378 in East Sumter | 01928-01-011928 | current | |
| SC 764 | 8.950 | 14.404 | US 76 / US 378 near Horrell Hill | US 601 near Eastover | 01942-01-011942 | current | |
| SC 765 | — | — | US 76 east of Hickory Tavern | SC 101 southwest of Gray Court | 01942-01-011942 | 01947-01-011947 | |
| SC 766 | — | — | US 221 in Laurens | A.B. Jacks Road southwest of Laurens | 01942-01-011942 | 01947-01-011947 | |
| SC 767 | — | — | US 76 west of Mullins | Gilchrist Road near Mullins | 01942-01-011942 | 01947-01-011947 | |
| SC 768 | — | — | Wahee Road near Marion | US 76 southwest of Marion | 01942-01-011942 | 01947-01-011947 | First form |
| SC 768 | 4.880 | 7.854 | SC 48 in Arthurtown | US 76 / US 378 / Hallbrook Drive in Eastmont | 01980-01-011980 | current | Second form |
| SC 769 | 9.590 | 15.434 | SC 4 in Gadsden | US 76 / US 378 in Horrell Hill | 01942-01-011942 | current | |
| SC 771 | — | — | SC 432 near Whitetown | SC 43 east of McCormick | 01942-01-011942 | 01947-01-011947 | |
| SC 772 | — | — | SC 9 southeast of Wallace | SC 77 in Fulton | 01942-01-011942 | 01947-01-011947 | |
| SC 773 | 5.490 | 8.835 | US 76 east of Prosperity | US 176 in Pomaria | 01942-01-011942 | current | |
| SC 774 | — | — | SC 186 near Dacusville | Pickens–Greenville county line west of Slater–Marietta | 01942-01-011942 | 01947-01-011947 | |
| SC 781 | 3.561 | 5.731 | US 278 southwest of White Pond | US 78 in White Pond | 01940-01-011940 | current | |
| SC 782 | — | — | SC 70 west of Denmark | SC 517 near Denmark | 01942-01-011942 | 01947-01-011947 | |
| SC 783 | — | — | SC 64 in Cottageville | US 78 in Dorchester | 01942-01-011942 | 01947-01-011947 | |
| SC 784 | — | — | SC 204 in Reevesville | US 78 in St. George | 01942-01-011942 | 01947-01-011947 | |
| SC 785 | — | — | SC 381 west of Blenheim | SC 381 southeast of Argyle | 01942-01-011942 | 01947-01-011947 | |
| SC 786 | — | — | US 17 / US 701 near Belle Isle Gardens | SC 716 in Belle Isle Gardens | 01942-01-011942 | 01947-01-011947 | |
| SC 790 | — | — | US 178 near Liberty | SC 13 in Liberty | 01942-01-011942 | 01947-01-011947 | |
| SC 791 | — | — | SC 384 northeast of Tatum | SC 79 northwest of McColl | 01942-01-011942 | 01947-01-011947 | |
| SC 801 | — | — | SC 8 south of Easley | SC 86 west of Piedmont | 01942-01-011942 | 01947-01-011947 | |
| SC 802 | 6.690 | 10.767 | US 21 / US 21 Bus. in Beaufort | Coosaw River Drive on Coosaw Island | 01942-01-011942 | current | Parts of the highway were replaced by US 21 / SC 128; signed to end slightly farther east of its official eastern terminus. |
| SC 803 | — | — | Burckmyer Drive on Gibbs Island | SC 285 in Beaufort | 01942-01-011942 | 01947-01-011947 | |
| SC 804 | — | — | SC 917 north of Ketchuptown | US 701 near Allsbrook | 01942-01-011942 | 01947-01-011947 | |
| SC 805 | — | — | SC 28 northwest of McCormick | SC 28 northwest of McCormick | 01942-01-011942 | 01947-01-011947 | |
| SC 810 | — | — | SC 13 east of Easley | Powdersville Road north of Powdersville | 01942-01-011942 | 01947-01-011947 | |
| SC 811 | — | — | SC 184 north of Lake Secession | SC 81 south of Homeland Park | 01942-01-011942 | 01947-01-011947 | |
| SC 812 | — | — | Crossing over an unnamed creek on Saint Helena Island | SC 285 in Frogmore | 01942-01-011942 | 01947-01-011947 | |
| SC 813 | — | — | Powell Road / Hole Avenue in North Santee | SC 528 in Sampit | 01942-01-011942 | 01947-01-011947 | |
| SC 814 | — | — | US 25 near Princeton | Dunklin Bridge Road near Princeton | 01942-01-011942 | 01947-01-011947 | |
| SC 815 | — | — | SC 72 near Greenwood | US 25 / US 178 northwest of Greenwood | 01942-01-011942 | 01947-01-011947 | |
| SC 816 | — | — | SC 368 northeast of Ridgeland | SC 170 near Ridgeland | 01942-01-011942 | 01947-01-011947 | |
| SC 817 | — | — | SC 104 northeast of McCormick | SC 10 in Troy | 01942-01-011942 | 01947-01-011947 | |
| SC 818 | — | — | SC 202 in Little Mountain | SC 177 near Peak | 01942-01-011942 | 01947-01-011947 | |
| SC 819 | — | — | SC 288 near Pumpkintown | SC 288 west of Pumpkintown | 01942-01-011942 | 01947-01-011947 | |
| SC 820 | — | — | Anderson–Pickens county line southeast of Easley | SC 13 in Easley | 01942-01-011942 | 01947-01-011947 | |
| SC 821 | — | — | SC 43 southwest of McCormick | SC 82 near Bordeaux | 01929-01-01c. 1929 | 01947-01-011947 | |
| SC 822 | — | — | Southwest of Lowndesville | SC 82 in Lowndesville | 01938-01-011938 | 01947-01-011947 | |
| SC 823 | 11.140 | 17.928 | SC 81 in Mount Carmel | SC 72 southwest of Abbeville | 01940-01-011940 | current | Two instances: 1940–1947 and 1950–present |
| SC 824 | — | — | Barnes Station | SC 82 south of Iva | 01940-01-011940 | 01947-01-011947 | |
| SC 831 | — | — | SC 381 northeast of Clio | SC 95 near Minturn | 01940-01-011940 | 01947-01-011947 | |
| SC 850 | — | — | SC 85 north of Chesterfield | NC 742 at the North Carolina state line north of Chesterfield | 01940-01-011940 | 01942-01-011942 | |
| SC 851 | — | — | SC 9 near Chesterfield | North Carolina state line northeast of Chesterfield | 01940-01-011940 | 01947-01-011947 | |
| SC 900 | — | — | SC 9 west of Mount Croghan | North Carolina state line northwest of Mount Croghan | 01942-01-011942 | 01947-01-011947 | |
| SC 901 | 38.730 | 62.330 | SC 200 near Mitford | SC 161 / SC 274 in Rock Hill | 01926-01-01c. 1926 | current | |
| SC 902 | — | — | SC 265 in Midway | SC 9 in High Point | 01935-01-01c. 1935 | 01951-01-011951 | |
| SC 903 | 27.090 | 43.597 | SC 151 / Catarah Road in Catarrh | US 521 Bus. / SC 200 / Elm Street in Lancaster | 01926-01-011926 | current | |
| SC 904 | — | — | US 701 near Bayboro | North Carolina state line north of Loris | 01936-01-011936 | 01952-01-01c. 1952 | |
| SC 905 | 25.610 | 41.215 | US 378 / US 701 in Conway | NC 905 at the North Carolina state line northeast of Longs | 01937-01-011937 | current | |
| SC 906 | — | — | US 521 / SC 9 in Lancaster | SC 9 southwest of Pageland | 01937-01-011937 | 01949-01-011949 | |
| SC 907 | — | — | SC 9 in Chester | SC 5 in Kings Creek | 01937-01-011937 | 01960-01-011960 | |
| SC 908 | 7.610 | 12.247 | US 378 / Woodberry Court near Brittons Neck | SC 41 near Brittons Neck | 01939-01-011939 | current | |
| SC 909 | 14.060 | 22.627 | SC 9 near Rodman | US 321 in Lowrys | 01940-01-011940 | current | |
| SC 910 | — | — | SC 151 southwest of Angelus | Wexford Road near Wexford | 01940-01-011940 | 01947-01-011947 | |
| SC 911 | — | — | Southeast of Wallace | SC 9 near Wallace | 01940-01-011940 | 01947-01-011947 | |
| SC 912 | 8.350 | 13.438 | US 15 / US 401 / Marlboro Road in Dyers Hill | SC 9 northwest of Bennettsville | 01940-01-011940 | current | |
| SC 913 | — | — | SC 41 southwest of Kemper | Ward Store Road at the North Carolina state line southeast of Hamer | 01940-01-011940 | 01947-01-011947 | |
| SC 914 | 1.720 | 2.768 | SC 9 Bus. on the Lancaster Mill–Lancaster line | SC 200 in Springdale | 01940-01-011940 | current | |
| SC 915 | — | — | SC 9 near Minturn | SC 9 southwest of Bennettsville | 01940-01-011940 | 01947-01-011947 | |
| SC 916 | — | — | SC 9 northwest of Little RockSC 83 southeast of McColl | SC 831 near ClioSC 381 in McColl | 01940-01-011940 | 01947-01-011947 | |
| SC 917 | 39.690 | 63.875 | SC 9 Bus. / SC 410 in Finklea | SC 38 west of Latta | 01940-01-011940 | current | |
| SC 918 | — | — | SC 9 west of Lancaster | SC 504 in Van Wyck | 01940-01-011940 | 01947-01-011947 | |
| SC 919 | — | — | SC 9 in Clio | SC 384 in Tatum | 01940-01-011940 | 01947-01-011947 | |
| SC 920 | — | — | SC 9 in Pageland | North Carolina state line northeast of Pageland | 01942-01-011942 | 01947-01-011947 | |
| SC 921 | — | — | SC 922 southeast of Sedalia | US 176 in Union | 01939-01-011939 | 01947-01-011947 | |
| SC 922 | — | — | SC 92 in Cross Keys | SC 921 southeast of Sedalia | 01940-01-011940 | 01947-01-011947 | |
| SC 923 | — | — | SC 9 in Antioch | North Carolina state line near Lancaster | 01942-01-011942 | 01947-01-011947 | |
| SC 930 | — | — | Southeast of Great Falls | SC 93 northeast of Great Falls | 01940-01-011940 | 01947-01-011947 | |
| SC 941 | — | — | US 301 near ManningNewman Branch Road southeast of New ZionPuddin Swamp Road east of New Zion | SC 527 near SardiniaSC 94 near New ZionSC 54 east of Turbeville | 01940-01-011940 | 01947-01-011947 | |
| SC 942 | — | — | Newman Branch Road south of New Zion | SC 543 north of New Zion | 01942-01-011942 | 01947-01-011947 | |
| SC 943 | — | — | SC 902 near White Bluff Crossroads | SC 96 in Taxahaw | 01942-01-011942 | 01947-01-011947 | |
| SC 944 | — | — | SC 522 northeast of Pleasant Hill | SC 341 near Antioch Acres | 01942-01-011942 | 01947-01-011947 | |
| SC 945 | — | — | SC 91 near Adamsburg | SC 9 in Adamsburg | 01942-01-011942 | 01947-01-011947 | |
| SC 946 | — | — | SC 901 southwest of Lesslie | Reservation Road east of Springstein | 01942-01-011942 | 01947-01-011947 | |
| Former ||||||||

## List of alternate routes

South Carolina alternate routes have been utilized in a multitude of ways, including business, bypass, cut-thru and spurs. Today, only one alternate route is currently active in the state.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed |
| SC 2 Alt. | — | — | US 76 / SC 2 in Slighs | US 76 / SC 2 in Little Mountain | 01940-01-01c. 1940 | 01947-01-011947 |
| SC 4 Alt. | — | — | SC 4 in Neeses | SC 5 in Neeses | 01940-01-01c. 1940 | 01947-01-011947 |
| SC 4 Alt. | — | — | US 21 in Orangeburg | SC 4 in Orangeburg | 01937-01-01c. 1937 | 01947-01-011947 |
| SC 5 Alt. | — | — | SC 5 in Hardeeville | US 17 / SC 46 in Hardeeville | 01939-01-011939 | 01947-01-011947 |
| SC 7 Alt. | — | — | US 176 northeast of Whitmire | SC 7 northeast of Whitmire | 01940-01-011940 | 01942-01-011942 |
| SC 9 Alt. | — | — | US 1 / US 52 in Cheraw | SC 9 in Cheraw | 01942-01-01c. 1942 | 01947-01-011947 |
| SC 9 Alt. | — | — | US 521 south of Lancaster | US 521 / SC 9 in Lancaster | 01942-01-01c. 1942 | 01947-01-011947 |
| SC 9 Alt. | — | — | SC 9 in Richburg | SC 901 in Richburg | 01939-01-011939 | 01947-01-011947 |
| SC 9 Alt. | — | — | SC 9 in Jonesville | SC 11 in Jonesville | 01938-01-011938 | 01947-01-011947 |
| SC 9 Alt. | — | — | SC 9 near Pacolet | US 176 in Spartanburg | 01946-01-011946 | 01947-01-011947 |
| SC 11 Alt. | — | — | SC 11 east of Chesnee | US 221 east of Chesnee | 01940-01-01c. 1940 | — |
| SC 13 Alt. | — | — | SC 250 in Greenville | SC 13 in Greenville | 01940-01-01c. 1940 | 01950-01-01c. 1950 |
| SC 18 Alt. | — | — | SC 184 in Antreville | SC 18 in Antreville | 01936-01-011936 | 01938-01-011938 |
| SC 18 Alt. | — | — | US 29 in Gaffney | SC 18 in Gaffney | 01938-01-011938 | 01940-01-011940 |
| SC 18 Alt. | — | — | Limestone Street in Gaffney | US 29 in Gaffney | 01940-01-011940 | 01947-01-011947 |
| SC 19 Alt. | — | — | US 25 near Trenton | SC 19 in Trenton | 01939-01-011939 | 01966-01-01c. 1966 |
| SC 22 Alt. | — | — | SC 22 in Greenwood | US 221 / SC 72 in Greenwood | 01940-01-01c. 1940 | 01947-01-011947 |
| SC 22 Alt. | — | — | SC 22 in Great Falls | SC 22 in Great Falls | 01937-01-01c. 1937 | 01947-01-011947 |
| SC 26 Alt. | — | — | SC 26 near Eastover | SC 26 near Eastover | 01937-01-011937 | 01942-01-01c. 1942 |
| SC 28 Alt. | — | — | SC 184 in Antreville | SC 28 / SC 284 in Antreville | 01938-01-011938 | 01947-01-011947 |
| SC 28 Alt. | 0.4 | 0.64 | SC 28 in Ellenton | Downtown Ellenton | 01937-01-01c. 1937 | 01942-01-011942 |
| SC 28 Alt. | — | — | SC 28 in Hampton | SC 28 in Hampton | 01938-01-011938 | 01947-01-011947 |
| SC 41 Alt. | 22.904 | 36.860 | SC 41 in Centenary | SC 41 / SC 57 in Fork | 01952-01-011952 | current |
| SC 51 Alt. | — | — | SC 51 in Pamplico | SC 51 in Pamplico | 01936-01-011936 | 01947-01-011947 |
| SC 53 Alt. | — | — | SC 341 near Hobbs Crossroads | SC 341 near Hobbs Crossroads | 01938-01-011938 | 01947-01-011947 |
| SC 61 Alt. | — | — | US 17 west of Charleston | SC 61 west of Charleston | 01940-01-011940 | 01947-01-011947 |
| SC 61 Alt. | — | — | SC 61 south of Summerville | SC 61 south of Summerville | 01936-01-011936 | 01947-01-011947 |
| SC 64 Alt. | — | — | SC 64 in Olar | SC 5 in Olar | 01937-01-011937 | 01947-01-011947 |
| SC 64 Alt. | — | — | US 17 in Walterboro | SC 64 in Walterboro | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 70 Alt. | — | — | SC 3 in Barnwell | SC 70 in Barnwell | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 72 Alt. | — | — | US 176 northeast of Whitmire | SC 72 northeast of Whitmire | 01942-01-011942 | 01947-01-011947 |
| SC 90 Alt. | — | — | US 501 / SC 90 in Conway | US 501 in Red Hill | 01937-01-011937 | 01947-01-011947 |
| SC 93 Alt. | — | — | SC 9 / SC 914 in Crocketts Crossroads | US 521 / SC 9 in Lancaster | 01937-01-011937 | 01947-01-011947 |
| SC 104 Alt. | — | — | SC 104 / SC 432 near Troy | SC 104 / SC 432 near Troy | 01942-01-011942 | 01947-01-011947 |
| SC 128 Alt. | — | — | SC 336 in Ridgeland | SC 128 in Ridgeland | 01946-01-01c. 1946 | 01947-01-011947 |
| SC 151 Alt. | — | — | SC 151 west of Hartsville | SC 151 in Hartsville | 01938-01-011938 | 01947-01-011947 |
| SC 151 Alt. | 7.4 | 11.9 | SC 151 southeast of Hartsville | SC 151 / Segars Mill Road west of Hartsville | 01954-01-011954 | 01972-01-01c. 1972 |
| SC 170 Alt. | 23.0 | 37.0 | US 17 Alt. near Levy | SC 46 / SC 170 near Levy | 01972-01-011972 | 02010-01-012010 |
| SC 171 Alt. | — | — | SC 171 in Salters | SC 171 in Salters | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 174 Alt. | — | — | SC 174 in Edisto Beach | Dock Site Road in Edisto Beach | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 175 Alt. | — | — | US 521 / SC 175 in Kingstree | US 52 north of Kingstree | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 179 Alt. | — | — | Morrison Street in McClellanville | SC 179 in McClellanville | 01939-01-01c. 1939 | 01947-01-011947 |
| SC 188 Alt. | — | — | SC 185 near Antreville | SC 188 near Antreville | 01940-01-011940 | 01942-01-011942 |
| SC 215 Alt. | — | — | SC 112 / SC 215 in Carlisle | SC 72 / SC 215 in Carlisle | 01942-01-01c. 1942 | 01946-01-011946 |
| SC 265 Alt. | — | — | SC 157 / SC 341 in Kershaw | SC 265 in Kershaw | 01941-01-01c. 1941 | 01946-01-011946 |
| SC 281 Alt. | — | — | SC 281 in Beaufort | US 21 in Beaufort | 01939-01-01c. 1939 | 01946-01-011946 |
| SC 322 Alt. | — | — | US 21 / SC 5 in Rock Hill | SC 322 in Rock Hill | 01940-01-011940 | 01959-01-01c. 1959 |
| SC 341 Alt. | — | — | SC 341 in Olanta | SC 341 north of Olanta | 01936-01-011936 | 01947-01-011947 |
| SC 391 Alt. | — | — | US 1 in Batesburg | SC 391 in Batesburg | 01936-01-011936 | 01947-01-011947 |
| SC 403 Alt. | — | — | SC 403 in Timmonsville | US 76 east of Timmonsville | 01940-01-011940 | 01947-01-011947 |
| SC 703 Alt. | — | — | SC 703 in Mount Pleasant | US 17 / US 701 in Mount Pleasant | 01940-01-011940 | 01945-01-011945 |
| SC 901 Alt. | — | — | SC 901 southwest of Lando | SC 901 in Lando | 01936-01-011936 | 01947-01-011947 |
| SC 906 Alt. | — | — | SC 906 east of Lancaster | Kelly Drive near Lancaster | 01942-01-01c. 1942 | 01947-01-011947 |
| Former ||||||||

## List of business loops

South Carolina business routes were first established in 1949. All business routes in the state are set up as a loop, meaning it will separate then converge back to the main highway. Typically, they serve to connect downtown areas in cities and towns in the state.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| SC 3 Bus. | 2.870 | 4.619 | SC 3 near Springfield | SC 3 northeast of Springfield | — | — | |
| SC 5 Bus. | 4.290 | 6.904 | SC 5 / SC 161 in York | SC 5 / Sutton Spring Road northwest of York | 01986-01-011986 | current | |
| SC 9 Bus. | 14.990 | 24.124 | SC 9 southeast of Loris | SC 9 south of Green Sea | 01982-01-011982 | current | |
| SC 9 Bus. | 2.400 | 3.862 | US 15 / US 401 / SC 9 / SC 38 / SC 38 Bus. in Bennettsville | SC 9 / SC 38 in Bennettsville | 01985-01-011985 | current | |
| SC 9 Bus. | 2.2 | 3.5 | SC 9 near Chesterfield | SC 9 near Chesterfield | 01949-01-011949 | 01956-01-011956 | |
| SC 9 Bus. | 5.370 | 8.642 | US 521 / SC 9 east of Lancaster | SC 9 west of Lancaster | 01967-01-011967 | current | |
| SC 9 Bus. | 2.850 | 4.587 | SC 9 / SC 72 / SC 97 / SC 121 east of Chester | US 321 / SC 9 in Gayle Mill | 01956-01-011956 | current | |
| SC 11 Bus. | — | — | SC 11 near Salem | SC 11 near Salem | 01971-01-011971 | 01976-01-011976 | |
| SC 28 Bus. | — | — | US 76 / US 123 / SC 28 west of Clemson | US 76 / US 123 Conn. / SC 28 near Clemson | 01962-01-011962 | 01964-01-011964 | |
| SC 28 Bus. | — | — | SC 28 near Seneca | SC 28 near Seneca | 01957-01-011957 | 02000-01-012000 | |
| SC 28 Bus. | 3.900 | 6.276 | US 76 / SC 28 west of Clemson | US 76 / SC 28 / Woody Road south of Pendleton | 01962-01-011962 | current | |
| SC 28 Bus. | 5.000 | 8.047 | US 76 / SC 28 in Northlake | US 29 / SC 28 in Homeland Park | 01960-01-011960 | current | |
| SC 28 Bus. | — | — | SC 28 near Abbeville | SC 28 near Abbeville | 01957-01-011957 | 01989-01-011989 | |
| SC 34 Bus. | 2.6 | 4.2 | SC 34 / SC 34 Conn. in Newberry | US 76 / SC 34 / SC 219 in Newberry | 01976-01-011976 | 02010-01-012010 | |
| SC 38 Bus. | 2.865 | 4.611 | SC 38 in Bennettsville | US 15 / US 401 / SC 9 / SC 38 in Bennettsville | 01985-01-01c. 1985 | current | |
| SC 41 Bus. | 4.660 | 7.500 | SC 41 near Andrews | SC 41 north of Andrews | 01996-01-011996 | current | |
| SC 56 Bus. | 3.090 | 4.973 | SC 56 / SC 72 in Clinton | SC 56 north of Clinton | — | — | |
| SC 64 Bus. | 2.660 | 4.281 | SC 64 in Walterboro | SC 64 in Walterboro | 01985-01-011985 | current | |
| SC 72 Bus. | 4.310 | 6.936 | SC 72 west of Greenwood | US 25 / US 178 / US 221 / SC 72 in Greenwood | 01961-01-011961 | current | |
| SC 72 Bus. | 3.310 | 5.327 | SC 72 / Chestnut Street in Clinton | SC 56 / SC 72 in Clinton | — | — | |
| SC 72 Bus. | 2.6 | 4.2 | SC 72 near Chester | SC 72 near Chester | 01954-01-011954 | — | |
| SC 72 Bus. | 1.8 | 2.9 | SC 72 / SC 121 / SC 901 in Rock Hill | US 21 Bus. / SC 5 in Rock Hill | 01961-01-011961 | — | |
| SC 97 Bus. | — | — | US 321 / SC 97 in Chester | US 321 / SC 97 in Chester | 01987-01-01c. 1987 | 02009-01-01c. 2009 | |
| SC 121 Bus. | 2.6 | 4.2 | SC 121 near Chester | SC 121 near Chester | 01964-01-011964 | — | |
| SC 151 Bus. | 7.540 | 12.134 | SC 151 southeast of Hartsville | SC 151 / Segars Mill Road west of Hartsville | 01958-01-011958 | current | |
| SC 151 Bus. | 3.190 | 5.134 | SC 151 south of Jefferson | SC 151 / Miller Road north of Jefferson | 01997-01-011997 | current | |
| SC 151 Bus. | 3.030 | 4.876 | SC 151 south of Pageland | US 601 / SC 151 in Pageland | 01983-01-011983 | current | |
| SC 161 Bus. | 4.460 | 7.178 | SC 5 / SC 5 Bus. / SC 161 in York | US 321 / SC 5 / SC 161 in York | — | — | |
| SC 252 Bus. | — | — | SC 252 in Ware Shoals | US 25 / SC 252 in Ware Shoals | — | — | Actually the SC 252 mainline signed as a business loop |
| Former ||||||||

## List of other special routes

South Carolina, on rare occasion, will utilize other uniquely bannered routes in the state. Listed here are connector routes, truck routes, and spur routes.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| SC 4 Truck | 17.500 | 28.164 | US 1 Truck / US 78 Truck / SC 4 / SC 118 / SC 302 east of Aiken | SC 4 / SC 302 in Kitchings Mill | — | — | |
| SC 5 Truck | 5.1 | 8.2 | SC 5 / SC 72 in Rock Hill | SC 5 / SC 901 in Rock Hill | — | 02013-01-012013 | |
| SC 5 Conn. | 1.040 | 1.674 | SC 322 in Rock Hill | SC 5 / SC 901 in Rock Hill | 02013-01-012013 | current | |
| SC 6 Conn. | 0.090 | 0.145 | SC 6 southwest of Irmo | SC 6 southwest of Irmo | — | — | Unsigned |
| SC 6 Truck | 0.770 | 1.239 | SC 47 / SC 47 Truck southwest of Elloree | SC 6 / SC 47 Truck / SC 267 in Elloree | — | — | Completely concurrent with SC 47 Truck |
| SC 6 Conn. | 1.685 | 2.712 | I-95 / US 15 / US 301 southeast of Santee | SC 6 southeast of Santee | — | — | Unsigned |
| SC 6 Truck | 2.270 | 3.653 | US 17 Alt. / SC 6 in Moncks Corner | US 52 / SC 6 / Main Street Extension in Moncks Corner | — | — | |
| SC 8 Conn. | 0.190 | 0.306 | SC 8 in Easley | SC 93 in Easley | — | — | |
| SC 9 Conn. | 0.170 | 0.274 | SC 9 in Lake View | SC 41 in Lake View | — | — | Unsigned |
| SC 9 Truck | 5.890 | 9.479 | US 1 / US 1 Truck / US 52 Truck / SC 9 in Cheraw | SC 9 west of Cheraw | — | — | |
| SC 9 Conn. | 0.090 | 0.145 | SC 9 in Jonesville | SC 18 in Jonesville | — | — | Unsigned |
| SC 12 Conn. | 0.450 | 0.724 | US 1 in West Columbia | US 378 in West Columbia | — | — | Unsigned |
| SC 12 Spur | 0.334 | 0.538 | SC 12 in Columbia | I-77 in Columbia | — | — | Unsigned |
| SC 14 Truck | 4.610 | 7.419 | SC 14 in Greer | US 29 / SC 14 / SC 290 Truck in Greer | — | — | |
| SC 18 Truck | 3.980 | 6.405 | US 176 / SC 215 south of Union | SC 18 in Union | — | — | |
| SC 18 Conn. | 0.520 | 0.837 | US 176 / SC 18 Truck / SC 215 in Union | SC 18 in Union | — | — | Unsigned |
| SC 18 Conn. | 2.310 | 3.718 | SC 11 / SC 18 in Gaffney | SC 18 in Gaffney | — | — | Signed as the SC 18 mainline |
| SC 19 Truck | 9.880 | 15.900 | SC 19 / SC 118 / SC 302 in Aiken | US 1 Truck / US 78 Truck / SC 19 / SC 118 in Aiken | — | — | |
| SC 19 Conn. | 0.130 | 0.209 | SC 19 in Aiken | US 1 / US 78 / SC 19 in Aiken | — | — | Signed as the SC 19 mainline |
| SC 19 Conn. | 2.040 | 3.283 | SC 19 / Greenhouse Road south of Trenton | SC 19 in Trenton | — | — | Unsigned |
| SC 20 Truck | 5.350 | 8.610 | SC 71 Truck / SC 72 / SR 203 Truck in Abbeville | SC 20 Conn. / SC 28 / SC 28 Conn. northwest of Abbeville | — | — | |
| SC 20 Conn. | 0.870 | 1.400 | SC 20 Truck / SC 28 / SC 28 Conn. northwest of Abbeville | SC 20 near Abbeville | — | — | Unsigned |
| SC 20 Conn. | 1.090 | 1.754 | SC 20 in Craytonville | SC 20 in Craytonville | — | — | |
| SC 23 Truck | 4.950 | 7.966 | US 25 / US 25 Truck / SC 23 in Edgefield | SC 23 / SC 430 east of Edgefield | — | — | |
| SC 28 Conn. | 0.420 | 0.676 | SC 71 in Abbeville | SC 20 Conn. / SC 20 Truck / SC 28 northwest of Abbeville | — | — | Unsigned |
| SC 31 Conn. | 2.300 | 3.701 | US 17 / Main Street in North Myrtle Beach | SC 90 north of North Myrtle Beach | — | — | Unsigned |
| SC 34 Conn. | 0.590 | 0.950 | SC 121 southwest of Newberry | SC 34 near Newberry | — | — | Unsigned |
| SC 34 Truck | 0.830 | 1.336 | US 1 Truck / US 521 / US 521 Truck in Camden | US 1 / US 1 Truck / US 521 Truck / SC 34 in Camden | — | — | Completely concurrent with US 1 Truck and US 521 Truck |
| SC 34 Truck | 13.510 | 21.742 | SC 34 / SC 151 in Darlington | SC 34 northeast of Darlington | — | — | |
| SC 34 Conn. | 0.300 | 0.483 | US 52 / US 401 / SC 34 Truck in Darlington | SC 34 / SC 151 in Darlington | — | — | Signed as "34–401 Connector" |
| SC 39 Conn. | 0.160 | 0.257 | SC 39 in Jones Crossroads | SC 391 in Jones Crossroads | — | — | Signed as part of SC 391 |
| SC 47 Truck | 1.080 | 1.738 | SC 6 Truck / SC 47 southwest of Elloree | SC 6 / SC 47 / SC 267 in Elloree | — | — | |
| SC 48 Truck | 0.580 | 0.933 | US 21 / US 21 Conn. / US 76 Conn. / US 176 / US 321 in Columbia | US 21 Conn. / US 76 / SC 48 in Columbia | — | — | Completely concurrent with US 21 Conn./US 76 Conn. |
| SC 49 Truck | 1.790 | 2.881 | SC 49 in Union | US 176 / SC 18 Truck / SC 49 / SC 215 in Union | — | — | |
| SC 49 Conn. | 3.090 | 4.973 | SC 49 southeast of Monarch Mill | SC 49 / Monarch School Drive in Monarch Mill | — | — | |
| SC 51 Conn. | 0.240 | 0.386 | SC 51 in Florence | US 52 / James Jones Avenue in Florence | — | — | Unsigned |
| SC 56 Conn. | 0.330 | 0.531 | SC 56 in Spartanburg | US 176 / SC 9 / Glendalyn Avenue in Spartanburg | — | — | Unsigned |
| SC 61 Conn. | 0.163 | 0.262 | SC 61 / Savage Road in Charleston | SC 61 in Charleston | — | — | Unsigned; signed as SC 61 instead |
| SC 61 Conn. | 0.272 | 0.438 | SC 61 near Summerville | SC 165 near Summerville | — | — | Unsigned |
| SC 66 Conn. | 0.180 | 0.290 | SC 56 southwest of Joanna | SC 66 southwest of Joanna | — | — | Unsigned |
| SC 71 Truck | 4.870 | 7.838 | SC 20 Truck / SC 72 / SC 203 Truck in Abbeville | SC 20 Truck / SC 28 / SC 71 in Abbeville | — | — | Entirely concurrent with SC 20 Truck |
| SC 72 Conn. | 0.150 | 0.241 | US 176 northeast of Whitmire | SC 72 / SC 121 northeast of Whitmire | — | — | Unsigned |
| SC 75 Truck | 4.63 | 7.45 | SC 5 / SC 75 near Van Wyck | US 521 / SC 75 near Van Wyck | — | — | |
| SC 90 Truck | 3.910 | 6.293 | US 378 / US 378 Truck / US 501 / US 701 / US 701 Truck in Conway | US 378 Truck / US 501 Bus. / US 701 Truck / SC 90 in Red Hill | — | — | Completely concurrent with US 378 Truck and US 701 Truck |
| SC 90 Conn. | 0.170 | 0.274 | Sea Mountain Highway in Little River | SC 90 in Little River | — | — | Unsigned |
| SC 92 Conn. | 0.060 | 0.097 | SC 92 in Enoree | US 221 in Enoree | — | — | Unsigned |
| SC 101 Truck | 5.610 | 9.028 | SC 80 / SC 101 in Greer | SC 14 / SC 101 / SC 290 / SC 290 Truck in Greer | — | — | |
| SC 105 Conn. | 0.150 | 0.241 | SC 211 in Saratt | SC 105 in Saratt | — | — | Unsigned |
| SC 105 Conn. | 0.350 | 0.563 | SC 105 near Draytonville | SC 105 near Draytonville | — | — | |
| SC 125 Conn. | 0.772 | 1.242 | US 1 / US 78 / US 278 in North Augusta | SC 125 in North Augusta | — | — | |
| SC 125 Truck | 1.730 | 2.784 | US 25 / SC 121 / SC 125 / SC 230 in North Augusta | US 25 Bus. / SC 125 in North Augusta | — | — | |
| SC 150 Truck | 0.570 | 0.917 | SC 150 in Pacolet | SC 150 in Pacolet | — | — | |
| SC 157 Truck | 1.330 | 2.140 | SC 157 / SC 341 / SC 341 Truck in Kershaw | US 521 / US 601 / SC 341 Truck in Kershaw | — | — | |
| SC 160 Conn. | 0.060 | 0.097 | US 21 Bus. / SC 160 in Fort Mill | US 21 Bus. in Fort Mill | — | — | Unsigned; is, in fact, the southbound lane of US 21 Bus., but neither highway is marked on this short portion. |
| SC 160 Truck | 6.990 | 11.249 | US 21 / SC 160 in Fort Mill | SC 160 / SC 460 in Fort Mill | — | — | |
| SC 169 Spur | — | — | Near Chelsea | SC 169 near Chelsea | 01942-01-011942 | 01947-01-011947 | |
| SC 200 Conn. | 0.490 | 0.789 | US 321 Bus. in Winnsboro | SC 200 in Winnsboro | — | — | Unsigned |
| SC 203 Truck | 0.592 | 0.953 | SC 20 Truck / SC 71 Truck / SC 72 in Abbeville | SC 203 in Abbeville | — | — | |
| SC 212 Conn. | 0.130 | 0.209 | SC 64 northeast of Bells Crossroads | SC 212 northeast of Bells Crossroads | — | — | Unsigned |
| SC 215 Conn. | 0.120 | 0.193 | SC 215 south of Union | SC 18 in Union | — | — | Unsigned |
| SC 252 Truck | 6.868 | 11.053 | SC 252 in Ware Shoals | US 25 / US 25 Bus. / SC 252 near Ware Shoals | — | — | |
| SC 281 Spur | — | — | 7th Street in Port Royal | SC 281 in Port Royal | 01963-01-011963 | 01982-01-011982 | |
| SC 290 Truck | 5.810 | 9.350 | US 29 / SC 14 Truck / SC 101 / SC 290 in Greer | SC 80 / SC 290 in Greer | — | — | |
| SC 292 Conn. | 0.770 | 1.239 | SC 292 in Lyman | US 29 in Wellford | — | — | Unsigned |
| SC 336 Conn. | 0.150 | 0.241 | SC 336 in Ridgeland | US 278 / US 278 Conn. / Town Square in Ridgeland | — | — | Unsigned |
| SC 341 Truck | 1.330 | 2.140 | SC 157 / SC 157 Truck / SC 341 in Kershaw | US 521 / US 601 / SC 157 Truck in Kershaw | — | — | |
| SC 385 Conn. | 1.060 | 1.706 | SC 385 in Bennettsville | US 15 / US 401 / SC 9 southeast of Bennettsville | — | — | Unsigned |
| SC 406 Spur | — | — | Near Shelton | SC 406 near Shelton | 01946-01-01c. 1946 | 01947-01-011947 | None |
| SC 430 Conn. | 0.180 | 0.290 | SC 23 Truck / SC 430 in Edgefield | US 25 / SC 23 Truck north of Edgefield | — | — | Unsigned |
| SC 453 Truck | 10.670 | 17.172 | US 176 Truck / SC 453 in Boyer | SC 45 / SC 453 in Eutawville | — | — | |
| SC 478 Temp. | 8.5 | 13.7 | I-26 in Cayce | US 76 / US 378 in Columbia | 01989-01-011989 | 01995-01-011995 | |
| SC 527 Conn. | 0.290 | 0.467 | SC 527 in Kingstree | SC 377 / Ashton Avenue in Kingstree | — | — | Unsigned |
| SC 544 Conn. | 0.860 | 1.384 | SC 544 in Red Hill | US 378 Truck / US 501 Bus. / US 701 Truck in Red Hill | — | — | Unsigned |
| SC 544 Conn. | 0.500 | 0.805 | SC 544 Conn. in Red Hill | US 501 in Red Hill | — | — | Unsigned |
| SC 768 Conn. | 1.059 | 1.704 | SC 768 / Pineview Drive near Columbia | Longwood Road near Columbia | — | — | Unsigned |
| Former ||||||||