# List of fictional assassins and bounty hunters

This is a list of fictional assassins and bounty hunters.
| Character | Work | Creator | Country of publication |
| 4-LOM | Star Wars | George Lucas | United States |
| Pasquale Acosta | Smokin' Aces | Joe Carnahan | United States |
| Adrenalynn | The Tenth | Tony Daniel | United States |
| Morrigan Aensland | Darkstalkers | Capcom | Japan |
| Agent 47 | Hitman | IO Interactive | Denmark |
| Spencer Aimes | Killers | Bob DeRosa | United States |
| Sofia Al-Azwar | John Wick: Chapter 3 – Parabellum | Derek Kolstad, Shay Hatten, Chris Collins, Marc Abrams | United States |
| Raza Hamidmi Al-Wazar | Iron Man | Mark Fergus, Hawk Ostby, Art Marcum, Matt Holloway | United States |
| Lord Alamout | Comics' Greatest World / Dark Horse Comics | Steven Grant, Team CGW | United States |
| Patroklos Alexander | Soulcalibur V | Namco | Japan |
| Johnny Alpha | Strontium Dog | John Wagner and Carlos Ezquerra | United Kingdom |
| Mickey Altieri | Scream 2 | Kevin Williamson | United States |
| Alucard | Hellsing | Kouta Hirano | United States |
| Amanaman | Star Wars | George Lucas | United States |
| Osiris Amanpour | Machete | Robert Rodriguez, Álvaro Rodriguez | United States |
| Sean Ambrose | Mission Impossible 2 | Robert Towne | United States |
| Aphrodite IX | Top Cow | David Wohl, David Finch | United States |
| Samus Aran | Metroid | Makoto Kano | Japan |
| Sterling Archer | Archer | Adam Reed | United States |
| Assassin X | Danger Girl | J. Scott Campbell, Andy Hartnell | United States |
| Corvo Attano | Dishonored | Arkane Studios, Bethesda Softworks | United States |
| Jarlaxle Baenre | Forgotten Realms | R.A. Salvatore | United States |
| Sergeant Ballard | Outland | Peter Hyams | United States |
| Miguel Bain | Assassins | The Wachowskis and Brian Helgeland | United States |
| Cad Bane | Star Wars | George Lucas, Dave Filoni, and Henry Gilroy | United States |
| Bucky Barnes | Marvel Comics | Joe Simon, Jack Kirby | United States |
| Ramon Bax | Schneider vs Bax | Alex van Warmerdam | Netherlands, Belgium |
| Bear, aka Ursa | Arrow | Various | United States |
| Tom Beckett | Sniper | Michael Frost Beckner, Crash Leyland | United States |
| Barry Berkman | Barry | Alec Berg, Bill Hader | United States |
| Yelena Belova | Marvel Cinematic Universe | Cate Shortland | United States |
| Rod Bender | Dick Tracy | Chester Gould | United States |
| Mr. Benedict | Last Action Hero | Shane Black, David Arnott | United States |
| Bennett | Commando | Joseph Loeb III, Matthew Weisman, Steven E. de Souza | United States |
| Bill, aka "Snakecharmer" | Kill Bill | Quentin Tarantino | United States |
| Mercury Black | RWBY | Monty Oum | United States |
| Black Krrsantan | Star Wars | Kieron Gillen and Salvador Larroca | United States |
| Black Noir | The Boys | Eric Kripke | United States |
| Black Star | Soul Eater | Atsushi Ohkubo | Japan |
| Martin Q. Blank | Grosse Pointe Blank | Tom Jankiewicz, D. V. DeVincentis, Steve Pink and John Cusack | United States |
| Bloodshot | Valiant Comics | Kevin VanHook, Don Perlin, Bob Layton | United States |
| Bloodsport | DC Comics | John Byrne | United States |
| Mack Bolan | The Executioner | Don Pendleton | United States |
| Ramsay Bolton | A Song of Ice and Fire | George R. R. Martin | United States |
| Sy Borgman | Harley Quinn | Justin Halpern | United States |
| Danz Borin | Star Wars | George Lucas | United States |
| Boris the Animal | Men in Black 3 | Etan Cohen | United States |
| Bossk | Star Wars | George Lucas | United States |
| Bella Donna Boudreaux | Marvel Comics | Scott Lobdell and Jim Lee | United States |
| Mireille Bouquet | Noir | Ryōe Tsukimura | Japan |
| Boushh | Star Wars | George Lucas | United States |
| Ellen Brandt | Marvel Cinematic Universe | Shane Black and Drew Pearce | United States |
| The Bride, aka "Black Mamba" | Kill Bill | Quentin Tarantino | United States |
| Mitchell Braddock | The Hit | Peter Prince | United States |
| Nicholas Brody | Homeland | Alex Gansa | United States |
| Bronn | A Song of Ice and Fire | George R. R. Martin | United States |
| Michael Bryce Jr | The Hitman's Bodyguard | Tom O'Connor | United States |
| Budd, aka "Sidewinder" | Kill Bill | Quentin Tarantino | United States |
| Bullet-Tooth Tony | Snatch | Guy Ritchie | United States |
| Bullfrog | Captain Laserhawk: A Blood Dragon Remix | Adi Shankar | France, United States |
| Bullseye | Marvel Comics | Marv Wolfman and John Romita Sr. | United States |
| Peter Burrell aka "Doctor Smith" | Mercury Rising | Lawrence Konner, Mark Rosenthal | United States |
| Bushman | Marvel Comics | Doug Moench, Bill Sienkiewicz | United States |
| Ront Byrnloo | Star Wars | George Lucas | United States |
| Cain | The Cape | NBC | United States |
| Toro Calican | Star Wars | Jon Favreau | United States |
| Areola Canasta | If Looks Could Kill | Fred Dekker, Darren Star | United States |
| Stuart Canmore aka Renaissance Hunter | Gargoyles | Disney Television Animation | United States |
| Captain Cold | DC Comics | John Broome, Carmine Infantino | United States |
| Champ | Goku Midnight Eye | Buichi Terasawa | Japan |
| Chance | Marvel Comics | David Michelinie and Mike Harris | United States |
| Chapel | Youngblood | Rob Liefeld | United States |
| Charlie and Wesley | Nurse Betty | John C. Richards and James Flamberg | United States |
| Mr. Chase | Marvel Comics | Sean McKeever, David Ross | United States |
| Chastity Marks | Chaos! Comics | Brian Pulido and Steven Hughes | United States |
| Cheshire | DC Comics | Marv Wolfman, George Pérez | United States |
| Chidi | John Wick franchise | Derek Kolstad | United States |
| Anton Chigurh | No Country for Old Men | Cormac McCarthy | United States |
| Chiun | The Destroyer | Warren Murphy, Richard Sapir | United States |
| Choko Tateoka, the "Troubadour of Darkness" | Crying Freeman | Kazuo Koike, Ryoichi Ikegami | Japan |
| Cinnamon | DC Comics | Roger McKenzie, Jack Abel, Danny Bulanadi | United States |
| Sandor Clegane aka "The Hound" | A Song of Ice and Fire | George R. R. Martin | United States |
| Coffin, aka The Ziggurat | Comics' Greatest World / Dark Horse Comics | Steven Grant, Team CGW | United States |
| Combustion Man | Avatar: The Last Airbender | Michael Dante DiMartino and Bryan Konietzko | United States |
| Sarah Connor | Terminator 2: Judgment Day | James Cameron, Gale Anne Hurd | United States |
| The Consultant | The International | Eric Warren Singer | United States |
| Contract hitmen | Outland | Peter Hyams | United States |
| Cooke | Commando | Jeph Loeb, Matthew Weisman, Steven E. de Souza | United States |
| Mark Cordell | The Juror | Ted Tally | United States |
| Michael Corleone | The Godfather | Mario Puzo | United States |
| Mia Corvere | Nevernight Chronicle | Jay Kristoff | Australia |
| Brisco County, Jr. | The Adventures of Brisco County, Jr. | Jeffrey Boam and Carlton Cuse | United States |
| Roland Cox | Jumper | Various | United States |
| Crystal Bowie | Cobra Space Adventure | Buichi Terasawa | United States |
| Curaré | Batman Beyond | Warner Bros. Family Entertainment | United States |
| Joey Cusack | A History of Violence | Josh Olson | United States |
| Ezio Auditore da Firenze | Assassin's Creed | Ubisoft | France |
| Daken | Marvel Comics | Daniel Way and Steve Dillon | United States |
| Dale and Ellen | The Night Agent | Seiichi Ishii | United States |
| Dante | Devil May Cry | Hideki Kamiya | Japan |
| Naoto Date | Tiger Mask | Ikki Kajiwara, Naoki Tsuji | Japan |
| Daud, aka The Knife of Dunwall | Dishonored | Arkane Studios, Bethesda Softworks | United States |
| David Cain | DC Comics | Kelley Puckett and Damion Scott | United States |
| Shelly De Killer | Ace Attorney | Capcom | Japan |
| Milady de Winter | The Three Musketeers | Alexandre Dumas | France |
| Deadpool | Marvel Comics | Fabian Nicieza and Rob Liefeld | United States |
| Deadshot | DC Comics | David Vern Reed, Lew Sayre Schwartz, Bob Kane | United States |
| Death's Head | Transformers / Doctor Who / Marvel Comics | Simon Furman and Geoff Senior | United States United Kingdom |
| Deathfist | Judge Dredd | John Wagner, Alan Grant, Barry Kitson | United States |
| Deathshadows | Stark Raven | Endless Horizons Entertainment | United States |
| Deathstroke the Terminator | DC Comics | Marv Wolfman, George Pérez | United States |
| Debnoli | Star Wars | George Lucas | United States |
| Rick Deckard | Do Androids Dream of Electric Sheep? | Philip K. Dick | United States |
| Per Degaton | Legends of Tomorrow | Various | United States |
| Rainn Delacourt | Jurassic World Dominion | Colin Trevorrow, Emily Carmichael, Derek Connolly | United States |
| Florence Delaunay | Sharpe's Assassin | Bernard Cornwell | United Kingdom |
| Delia, aka "Blue Eyes" | Sin City | Frank Miller | United States |
| Mona Demarkov | Romeo Is Bleeding | Hilary Henkin | United States |
| Dengar | Star Wars | George Lucas | United States |
| Jack Devlin | The Net | John Brancato and Michael Ferris | United States |
| Merle Dixon | The Walking Dead | Robert Kirkman | United States |
| Din Djarin | Star Wars | Jon Favreau | United States |
| Dirty Ezio | Robin Hood: Men in Tights | Mel Brooks | United States |
| Dog | Marvel Comics, Ultraverse | Warren Ellis | United States |
| Domino | Marvel Comics | Fabian Nicieza, Rob Liefeld | United States |
| Walter C. Dornez | Hellsing | Kouta Hirano | United States |
| Rico Dredd | Judge Dredd | John Wagner | United States |
| Drei | Phantom of Inferno | Nitroplus | Japan |
| Jessica Drew (Spider-Woman) | Marvel Comics | Archie Goodwin, Marie Severin | United States |
| Elle Driver, aka "California Mountain Snake" | Kill Bill | Quentin Tarantino | United States |
| Oscar Dzundza, aka The Golem | Sherlock | Mark Gatiss and Steven Moffat | United Kingdom |
| Jubal Early | Firefly | Joss Whedon | United States |
| Mai Lee East | Wild Wild West | Various | United States |
| Ein | Phantom of Inferno | Nitroplus | Japan |
| El Cameleón | Machete Kills | Robert Rodriguez, Marcel Rodriguez, Kyle Ward | United States |
| El Cirujano | Sniper (1993) | Robert Rodriguez, Marcel Rodriguez, Kyle Ward | United States |
| El Mariachi | El Mariachi | Robert Rodriguez | Mexico |
| Elektra | Marvel Comics | Frank Miller | United States |
| Artemis Entreri | Forgotten Realms | R.A. Salvatore | United States |
| Jackie Estacado | The Darkness | Top Cow | United States |
| Soul Evans | Soul Eater | Atsushi Ohkubo | Japan |
| Captain Falcon | F-Zero | Shigeru Miyamoto | Japan |
| Sofia Falcone, aka Sofia Falcone-Gigante | DC Comics | Jeph Loeb | United States |
| Mickey Fallon | Killing Them Softly | Andrew Dominik | United States |
| FitzChivalry Farseer | Farseer Trilogy | Robin Hobb | United States |
| Ilsa Faust | Mission: Impossible film series | Christopher McQuarrie | United States |
| Margot Fenring | Dune | Frank Herbert | United States |
| Boba Fett | Star Wars | George Lucas | United States |
| Jango Fett | Star Wars | George Lucas | United States |
| Firefly | G.I. Joe | Larry Hama, various | United States |
| Sam Fisher | Splinter Cell franchise | Tom Clancy | United States |
| Mr. Fixx | Batman Beyond | Various | United States |
| Phoebe Frady aka The Shadow | Heroes Reborn | Various | United States |
| Django Freeman | Django Unchained | Quentin Tarantino | United States |
| Mr. Freeze | Smallville | Various | United States |
| Mahiro Fukagawa | Baby Assassins | Yugo Sakamoto | Japan |
| Galilean | Chaos! Comics | Brian Pulido | United States |
| Gamora | Marvel Comics | Jim Starlin | United States |
| Gandrayda | Metroid Prime 3: Corruption | Andrew Jones | United States |
| Richard "Cherry" Ganz | Another 48 Hrs. | John Fasano, Jeb Stuart, Larry Gross | United States |
| Gazelle | Kingsman: The Secret Service | Matthew Vaughn and Jane Goldman | United States |
| Ghazan | Avatar: The Legend of Korra | Tim Hedrick | United States |
| The gholam | Wheel of Time | Robert Jordan | United States |
| Ghor | Metroid Prime 3: Corruption | Andrew Jones | United States |
| Ghost Dog | Ghost Dog: The Way of the Samurai | Jim Jarmusch | United States |
| Ra's al Ghul | DC Comics | Dennis O'Neil, Neal Adams, Julius Schwartz | United States |
| Nyssa al Ghul | DC Comics | Greg RuckaKlaus Janson | United States |
| Wesley Gibson | Top Cow (Millarworld) | Mark Millar, J. G. Jones | United States |
| Armon Gill | Judge Dredd | John Wagner, Will Simpson | United States |
| Gillecomgain, aka Hunter | Gargoyles | Walt Disney Television Animation | United States |
| Richard Gladwell | Gotham | Warner Bros. Television | United States |
| Sidney Glass | Once Upon a Time | Edward Kitsis, Adam Horowitz | United States |
| Jonas Glim | DC Comics | Alan Grant, Val Semeiks | United States |
| Goggles and Hicks | The Cape | NBC | United States |
| Mr. Goodkat/Smith | Lucky Number Slevin aka The Wrong Man | Jason Smilovic | United States |
| Superintendent Grail | Enola Holmes 2 | Jack Thorne, Harry Bradbeer | United Kingdom |
| Donovan "Red" Grant | James Bond | Ian Fleming | United Kingdom |
| Michael Grant | The Last Hit | Reginald Hill, Walter Klenhard, Alan Sharp | United Kingdom |
| Greedo | Star Wars | George Lucas | United States |
| Vernita Green, aka "Copperhead" | Kill Bill | Quentin Tarantino | United States |
| Grey Men | Wheel of Time | Robert Jordan | United States |
| Grimalkin | Spook's | Joseph Delaney | United States |
| Grocer | Grosse Pointe Blank | Tom Jankiewicz, D. V. DeVincentis, Steve Pink and John Cusack | United States |
| Ilsa Grunt | If Looks Could Kill | Fred Dekker, Darren Star | United States |
| Sir William Gull | From Hell | Alan Moore, Eddie Campbell | United States |
| Gunhawk, aka Gunnery Sgt. Liam Hawkleigh | DC Comics | Chuck Dixon, Graham Nolan, Scott Hanna | United States |
| The Gunslinger | Astro City | Kurt Busiek | United States |
| Gwen Poole | Marvel Comics | Christopher Hastings, Heather Antos, Jordan D. White, Chris Bachalo | United States |
| Red Harlow | Red Dead | Rockstar San Diego | United States |
| Han Cho Bai | Red 2 | Jon Hoeber and Erich Hoeber | United States |
| The Harpists | Kung Fu Hustle | Stephen Chow | China |
| Harry Heck | The Punisher | Michael France and Jonathan Hensleigh | United States |
| Maki Harukawa | Danganronpa V3: Killing Harmony | Spike Chunsoft | Japan |
| The Hassassin, aka "Mr. Grey" | Angels & Demons | Dan Brown | United States |
| The Hassansins | Prince of Persia: The Sands of Time | Jordan Mechner | United States |
| Judy Havelock | James Bond, For Your Eyes Only | Ian Fleming | United Kingdom |
| Melina Havelock | James Bond, For Your Eyes Only | Richard Maibaum, Michael G. Wilson | United Kingdom |
| Ryu Hayabusa | Ninja Gaiden | Tecmo | Japan |
| Maggie Hayward/"Nina"/"Claudia Anne Doran" | Point of No Return aka The Assassin | Robert Getchell, Alexandra Seros | United States |
| Henriques | Commando | Joseph Loeb III, Matthew Weisman, Steven E. de Souza | United States |
| Karl Hertz | Shoot 'Em Up | Michael Davis | United States |
| Jonah Hex | DC Comics | John Albano and Tony DeZuniga | United States |
| Yō Hinomura, the "Crying Freeman" | Crying Freeman | Kazuo Koike, Ryoichi Ikegami | Japan |
| Hit | Dragon Ball | Akira Toriyama | Japan |
| Hit-Girl | Icon/Image Comics (Millarworld) | Mark Millar, Dave Gibbons | United States |
| Hitman (Tommy Monaghan) | DC Comics | Garth Ennis and John McCrea | United States |
| Hitman | Marvel Comics | Archie Goodwin and Sal Buscema | United States |
| Hit-Monkey | Marvel Comics | Daniel Way, Dalibor Talajić | United States |
| Hitpig | Hitpig! | Berkeley Breathed | United States |
| HK-47 | Star Wars | David Gaider | United States |
| Ed Hopper | Mr. Right | Max Landis | United States |
| The Hornet | Bullet Train | Columbia Pictures | United States |
| Mike Howell | American Ultra | Max Landis | United States |
| Mr. Hudson | Wild Wild West | Various | United States |
| Huntress | DC Extended Universe | Christina Hodson | United States |
| Hvitserk | The Broken Empire | Mark Lawrence | United States |
| Altaïr Ibn-La'Ahad | Assassin's Creed | Ubisoft | France |
| IG-11 | Star Wars | Jon Favreau | United States |
| IG-88 | Star Wars | George Lucas | United States |
| Mr. Igoe | Innerspace | Jeffrey Boam, Chip Proser | United States |
| Iria | Zeiram | Keita Amemiya | Japan |
| Ysanne Isard, aka Iceheart | Star Wars | George Lucas | United States |
| Sidon Ithano | Star Wars | J. J. Abrams | United States |
| The Jackal | The Day of the Jackal | Frederick Forsyth | United Kingdom |
| Whitey Jackson | Foul Play | Colin Higgins | United States |
| Jaws | James Bond | Ian Fleming | United Kingdom |
| Jazinda | Marvel Comics | Peter David | United States |
| Dannik Jerriko | Star Wars | George Lucas | United States |
| Jim Ti-Sam / Thunder Leg | Drunken Master | Siao Lung and Ng See-yuen | Hong Kong |
| Jinx | G.I. Joe | Larry Hama | United States |
| Jitterjack | Astro City | Kurt Busiek | United States |
| Ah Jong | The Killer | John Woo | Hong Kong |
| Mr. Joshua/Sub-Commander Jack Joshua | Lethal Weapon | Shane Black | United States |
| J'Quille | Star Wars | George Lucas | United States |
| The Judgement Knights | Comics' Greatest World / Dark Horse Comics | Steven Grant, Team CGW | United States |
| Kai | Lexx | Lex Gigeroff | Canada |
| Kain | Legacy of Kain | Silicon Knights | United States |
| Kaine Parker | Marvel Comics | Terry Kavanagh and Steven Butler | United States |
| Kanako, aka the Spider Woman | Wicked City | Hideyuki Kikuchi | Japan |
| Kanden | Metroid Prime Hunters | Andrew Jones, Richard Vorodi, and Michael Harrington | United States |
| Kanto | DC Comics | Jack Kirby | United States |
| Jodo Kast | Star Wars | Various | United States |
| Paul Kellerman | Prison Break | Paul Scheuring | United States |
| Sarah Kerrigan | Starcraft | Chris Metzen, James Phinney | United States |
| Kesskass | Trigun | Yasuhiro Nightow | Japan |
| Kevin | Sin City | Frank Miller | United States |
| Khamel | The Pelican Brief | John Grisham | United States |
| Killer Cleaner | Johnny English Reborn | William Davies and Hamish McColl | United States |
| Solf J. Kimblee | Fullmetal Alchemist | Hiromu Arakawa | Japan |
| Yuichi Kimura | Bullet Train | Kōtarō Isaka | Japan |
| Richard "Richie" Kirsch | Scream | Various | United States |
| Kitche | Crying Freeman | Kazuo Koike, Ryoichi Ikegami | Japan |
| The Knave of Hearts | Alice in Wonderland | Tim Burton | United States |
| Kommando aka John Smith | BloodRayne | Terminal Reality | United States |
| Michael Korda | Metro | Randy Feldman | United States |
| Mr. Kornfeldt | Killers | Bob DeRosa | United States |
| Kraab | Ben 10 | Man of Action | United States |
| Jack Krauser | Resident Evil 4 | Capcom | Japan |
| Darth Krayt | Star Wars | Various | United States |
| Officer Krieger | Blade | David S. Goyer | United States |
| Thane Krios | Mass Effect franchise | BioWare | Canada |
| Karl Ruprecht Kroenen | Hellboy | Mike Mignola | United States |
| Kujaku, aka the Peacock Lady | Goku Midnight Eye | Buichi Terasawa | Japan |
| Lady Deathstrike | Marvel Comics | Dennis O'Neil, William Johnson, Bill Mantlo, Sal Buscema | United States |
| Lady Shiva | DC Comics | Dennis O'Neil, Ric Estrada | United States |
| Lady Une | Mobile Suit Gundam Wing | Sunrise | Japan |
| Solomon Lane | Mission: Impossible film series | Christopher McQuarrie | United States |
| Colonel Philippe Lanier | Sharpe's Assassin | Bernard Cornwell | United Kingdom |
| Felix LaPoubelle | Grosse Pointe Blank | Tom Jankiewicz, D. V. DeVincentis, Steve Pink and John Cusack | United States |
| Mike Lawton | Blame It on the Bellboy | Mark Herman | United States |
| Mitch Leary aka "Booth" | In the Line of Fire | Jeff Maguire | United States |
| John Lee | The Replacement Killers | Ken Sanzel | United States |
| Lemon and Tangerine | Bullet Train | Kōtarō Isaka | Japan |
| Leon and "That Hillbilly Kid" | Todd McFarlane's Spawn | Todd McFarlane | United States |
| The Leper Queen | Marvel Comics | Peter Milligan, Salvador Larroca | United States |
| Colonel Philippe Leroux | Sharpe's Sword | Bernard Cornwell | United Kingdom |
| Lilly | Todd McFarlane's Spawn | Todd McFarlane | United States |
| Morten Lindström | Kingsman: The Secret Service | Jane Goldman, Matthew Vaughn | United States |
| Miss Lippenrieder | Wild Wild West | Various | United States |
| Lobo | DC Comics | Roger Slifer, Keith Giffen | United States |
| Lockdown | Transformers | Derrick J. Wyatt | United States |
| Jonny Logan | Edizioni Dardo | Romano Garofalo, Leone Cimpellin | Italy |
| Prince Lotor | Voltron: Legendary Defender | DreamWorks Animation Television, World Events Productions | United States |
| Spicer Lovejoy | Titanic | James Cameron | United States |
| Nestor Lozano | Designated Survivor | David Guggenheim | United States |
| Vincent Ludwig | The Naked Gun: From the Files of Police Squad! | Jerry Zucker, Jim Abrahams, David Zucker, Pat Proft | United States |
| Lunacy | Stark Raven | Endless Horizons Entertainment | United States |
| Lunatik | Marvel Comics | Keith Giffen | United States |
| Macheath, aka Mack the Knife | Mack the Knife | Kurt Weill, Bertolt Brecht | Germany |
| Noah 'Il Duce' MacManus | The Boondock Saints | Troy Duffy | United States |
| Mad March | Alice | Nick Willing | Canada, United States |
| Mad Pierrot | Cowboy Bebop | Keiko Nobumoto, Toshihiro Kawamoto | Japan |
| Madame B. | Avengers: Age of Ultron | Joss Whedon | United States |
| Madame Masque | Marvel Comics | Stan Lee, Gene Colan | United States |
| Madcap | Marvel Comics | Mark Gruenwald, Paul Neary | United States |
| Mario Maghari | On the Job, aka OTJ | Various | United States |
| Mai | Cyborg 009 | Shotaro Ishinomori | Japan |
| Mailman assassin | Three Days of the Condor | Lorenzo Semple Jr., David Rayfiel | United States |
| Malachi | Agents of S.H.I.E.L.D. | Various | United States |
| Patrick Malone | Gotham | Bruno Heller | United States |
| "The Man on the Bridge" | Le Samouraï | Jean-Pierre Melville, Georges Pellegrin | United States |
| The Man with No Name | Dollars Trilogy | Sergio Leone | Italy |
| Stefano Mandrogora | The Zeta Project | Warner Bros. Television Animation | United States |
| Manheim | The Bourne Identity | Tony Gilroy, William Blake Herron | United States |
| Mano | DC Comics | Jim Shooter, Curt Swan | United States |
| Marcus | John Wick franchise | Derek Kolstad | United States |
| Maria | Lupin III: The Hemingway Papers | Various | Japan |
| Marie | Dune franchise | Frank Herbert | United States |
| Marrok | Star Wars | George Lucas | United States |
| Martian Madame | Mars Attacks! | Jonathan Gems, Tim Burton | United States |
| Mathayus the Akkadian | The Scorpion King | Stephen Sommers, Jonathan Hales | United States |
| Mathilde | The American | Rowan Joffé | United States |
| Maugrim | The Chronicles of Narnia | C. S. Lewis | United States |
| PJ Maybe | Judge Dredd | John Wagner | United Kingdom |
| Mazikeen | Lucifer | DC Comics | United States |
| Hank McCain | Machine Gun McCain | Mino Roli, Giuliano Montaldo, Israel Horovitz | Italy |
| Willem "Wildboy Willie" McCone | Comics' Greatest World / Dark Horse Comics | Steven Grant, Team CGW | United States |
| Steve McKenna | The Mechanic | Lewis John Carlino | United States |
| Meat Rack aka Oleg Kupov | Ultraverse | Malibu Comics, Marvel Comics | United States |
| Mega Man X | Mega Man X | Capcom | Japan |
| Megatak | Marvel Comics | Doug Moench, Alan Kupperberg | United States |
| "Megan Walsh" aka Agent 83 | Barely Lethal | John D'Arco | United States |
| Mei | House of Flying Daggers | Li Feng, Peter Wu, Wang Bin, Zhang Yimou | China, Hong Kong |
| Men of Leng aka Merchants aka Men in Turbans | The Dream-Quest of Unknown Kadath | H. P. Lovecraft | United States |
| Mercenary Tao, also known as Tao Pai Pai | Dragon Ball | Akira Toriyama | Japan |
| Mr. Mercer | Pirates of the Caribbean (film series) | Ted Elliott, Terry Rossio | United States |
| Merlyn the Archer | DC Comics | Mike Friedrich, Neal Adams, Dick Dillin | United States |
| Malcolm Merlyn | Arrow | Various | United States |
| Mero of Braavos aka The Titan's Bastard | A Song of Ice and Fire | George R. R. Martin | United States |
| Merrick | Todd McFarlane's Spawn | Todd McFarlane | United States |
| Metal Sonic | Sonic the Hedgehog | Various | Japan |
| Metallo | DC Animated Universe | Various | United States |
| Metallo | Supergirl | Various | United States |
| Mey-Rin | Black Butler | Yana Toboso | Japan |
| Krombopulos Michael | Rick and Morty | Justin Roiland and Dan Harmon | United States |
| Miho | Sin City | Frank Miller | United States |
| Mileena | Mortal Kombat franchise | Midway Games | United States |
| Mallorie "Mal" Miles-Cobb | Inception | Christopher Nolan | United States |
| Richard Miller | Sniper | Michael Frost Beckner, Crash Leyland | United States |
| Sean Miller | Patriot Games | Tom Clancy | United States |
| Mindboggler aka Leah Wasserman aka Ifrit aka Angel Moore | DC Comics | Joey Cavalieri, Rafael Kayanan | United States |
| Ming-Hua | Avatar: The Legend of Korra | Tim Hedrick | United States |
| Mini-Me | Austin Powers: The Spy Who Shagged Me | Mike Myers | United States |
| Miss Topsey & Miss Turvey | Nanny McPhee and the Big Bang | Emma Thompson | United Kingdom |
| Mister X | Marvel Comics | Frank Tieri, Sean Chen | United States |
| Mister X | Tiger Mask | Ikki Kajiwara, Naoki Tsuji | Japan |
| Mizuki | Dead or Alive 2: Birds | Masa Nakamura | Japan |
| Molten Man | The Spectacular Spider-Man | Various | United States |
| Ephant Mon | Star Wars | George Lucas | United States |
| The Monkey Man | Raiders of the Lost Ark | Lawrence Kasdan | United States |
| Leone "Léon" Montana | Léon: The Professional | Luc Besson | France |
| Montross | Star Wars | Various | United States |
| Colonel Sebastian Moran | Sherlock Holmes | Arthur Conan Doyle | United Kingdom |
| Sabine Moreau | Mission: Impossible film series | Josh Appelbaum and André Nemec | United States |
| Colonel Douglas Mortimer | For a Few Dollars More | Sergio Leone | Italy |
| The Mother | The Mother | Misha Green | United States |
| Francis Munch | Mr. Right | Max Landis | United States |
| Munitia | Wild Wild West | Various | United States |
| Murasaki aka Purple | Dragon Ball | Akira Toriyama | Japan |
| Murdoc | MacGyver | Lee David Zlotoff | United States |
| Muse | Marvel Comics | Charles Soule, Ron Garney | United States |
| Mustafa | Austin Powers | Mike Myers | United States |
| The Myrmidons | John Wick franchise | Derek Kolstad | United States |
| Myron | The Hit | Peter Prince | United States |
| Nadia | The Boys | Eric Kripke | United States |
| Misako Nakajo | Branded to Kill | Hachiro Guryu | Japan |
| Nanao, aka "Ladybug" | Bullet Train | Kōtarō Isaka | Japan |
| Nasir | Robin of Sherwood | Richard Carpenter | United Kingdom |
| Nazgûl | The Lord of the Rings | J. R. R. Tolkien | United Kingdom |
| The Nazgûl Sisters | Middle-earth: Shadow of War | Monolith Studios | United States |
| Nebula | Marvel Comics | Roger Stern, John Buscema | United States |
| Necros | James Bond, The Living Daylights | Eon Productions | United Kingdom |
| Needlenose | The Transformers | Hasbro | United States |
| Neesh | Star Wars | George Lucas | United States |
| Nekron | DC Comics | Mike W. Barr, Len Wein, Joe Staton | United States |
| Nemesis T-Type | Resident Evil franchise | Capcom | Japan |
| Neopolitan aka Neo | RWBY | Monty Oum | United States |
| Nero | One Piece | Eiichiro Oda | Japan |
| Newtralizer, born K'Vathrak | Teenage Mutant Ninja Turtles | Various | United States |
| Ngoc Minh Quan | The Foreigner | David Marconi | United States |
| Night Fright, aka Night Sight aka the Phantom Assassin | Metal Gear 2: Solid Snake | Hideo Kojima | Japan |
| Nightbird (Transformers) | The Transformers | Hasbro | United States |
| Nightmare | Soulcalibur | Project Soul | Japan |
| Nightmare Terminator | Terminator: The Sarah Connor Chronicles | Josh Friedman | United States |
| Nightslayer | DC Comics | Doug Moench, Gene Colan | United States |
| Nikita | La Femme Nikita | Luc Besson | France |
| Nimue | Once Upon a Time | Edward Kitsis, Adam Horowitz | United States |
| Ninjara | Teenage Mutant Ninja Turtles Adventures | Various | United States |
| Nitro | Marvel Comics | Jim Starlin | United States |
| Nixon, aka Unit Four | Hard Boiled (comics) | Frank Miller | United States |
| Noah the Akkadian | The Scorpion King | Stephen Sommers, Jonathan Hales | United States |
| Nora | Witchblade | Top Cow | United States |
| Ian Nottingham | Witchblade | Top Cow | United States |
| Noxus | Metroid Prime Hunters | Andrew Jones and Richard Vorodi | United States |
| Nuke | Marvel Comics | Frank Miller, David Mazzucchelli | United States |
| Ten Numb | Star Wars | George Lucas | United States |
| Number 22 | Baoh the Visitor | Hirohiko Araki | Japan |
| The Number One Killer | Branded to Kill | Hachiro Guryu | Japan |
| Snake Plissken | Escape from New York | John Carpenter, Nick Castle | United States |
| Paddy O'Brien | Austin Powers | Mike Myers | United States |
| Seamus O'Grady | Charlie's Angels: Full Throttle | John August, Cormac Wibberley, Marianne Wibberley | United States |
| O-Ren Ishii, aka "Cottonmouth" | Kill Bill | Quentin Tarantino | United States |
| Oburi | Kite | Yasuomi Umetsu | Japan |
| Ochi | Star Wars | George Lucas | United States |
| Octopunch | Transformers | Hasbro | United States |
| Satoshi Oji, aka "The Prince" | Bullet Train | Kōtarō Isaka | Japan |
| Old Joe | Looper | Rian Johnson | United States |
| Oliver Queen | Arrow | The CW | United States |
| Omar | Marvel Cinematic Universe | Disney | United States |
| Omega-1 | The Flash | Danny Bilson and Paul De Meo | United States |
| Xenia Onatopp | James Bond, GoldenEye | Eon Productions | United Kingdom |
| One-Eyed Jack | The Long Kiss Goodnight | Shane Black | United States |
| The One-Armed Man (Gus Evans) aka "Fred Johnson" | The Fugitive | Roy Huggins | United States |
| The One-Armed Man (Fredrick Sykes) | The Fugitive | David Twohy, Jeb Stuart | United States |
| Onomatopoeia | DC Comics | Kevin Smith, Phil Hester | United States |
| The Operative | Serenity | Joss Whedon | United States |
| Order of the Night Wind | Star Wars | George Lucas | United States |
| Orion | Avengers Confidential: Black Widow & Punisher | Marvel Entertainment, Sony Pictures Entertainment Japan, Madhouse | United States, Japan |
| Orions/Ur'eon/Kolari | Star Trek: The Original Series | Gene Roddenberry | United States |
| Orlok the Assassin | Judge Dredd | 2000 AD | United Kingdom |
| Oswald Cobblepot aka The Penguin | Gotham | Warner Bros. Television | United States |
| Oswald Cobblepot | Batman: The Telltale Series | Telltale | United States |
| Outer Heaven | Metal Gear franchise | Hideo Kojima | Japan |
| Overt-Kill | Spawn | Todd McFarlane | United States |
| Owlman | JLA: Earth 2 | DC Comics | United States |
| P'Li | Avatar: The Legend of Korra | Tim Hedrick | United States |
| Mrs. Phyllis H. Paddock | The X-Files | Chris Carter | United States |
| Palo | The American | Rowan Joffé | United States |
| Panty and Stocking | Panty & Stocking with Garterbelt | TAGRO | Japan |
| Parasite (Joshua Michael Allen) | DC Comics | Aaron Kuder, Dan Brown | United States |
| Tom Paxton | Prison Break: The Conspiracy | ZootFly | United States |
| Pe Ell | The Druid of Shannara | Terry Brooks | United States |
| Peacemaker (Christopher Smith) | DC Comics | Joe Gill, Pat Boyette | United States |
| The Penguins | Gotham | Bruno Heller | United States |
| Ms. Perkins | John Wick franchise | Derek Kolstad | United States |
| The Phantasm | Batman: Mask of the Phantasm | Alan Burnett, Paul Dini, Bruce Timm | United States |
| Phil | Cyborg 009 | Shotaro Ishinomori | Japan |
| Lumen Pierce | Dexter | James Manos Jr. | United States |
| Pistolera, formerly Gunbunny | DC Comics | Chuck Dixon, Graham Nolan, Scott Hanna | United States |
| Plastoid | Marvel Comics | Stan Lee, Gene Colan | United States |
| Stephanie Plum | One for the Money | Janet Evanovich | United States |
| Greg Portman | The Bodyguard | Lawrence Kasdan | United States |
| The Predacons (Transformers) | The Transformers | Hasbro | United States |
| Pretty Riki | Kill Bill | Quentin Tarantino | United States |
| Jessica Priest | Spawn franchise | Todd McFarlane | United States |
| The Professor | The Bourne Identity | Tony Gilroy, William Blake Herron | United States |
| Prometheus | DC Comics | Grant Morrison, Arnie Jorgensen | United States |
| Psy-Crow | Earthworm Jim | Doug TenNapel | United States |
| Pucker Puss | Dick Tracy | Chester Gould | United States |
| Djas Puhr | Star Wars | George Lucas | United States |
| Puma | Marvel Comics | Tom DeFalco, Ron Frenz | United States |
| Pumpkinhead | Pumpkinhead | Gary Gerani, Mark Patrick Carducci | United States |
| The Punisher | Marvel Comics | Gerry Conway, John Romita Sr., Ross Andru | United States |
| Python | Metal Gear franchise | Hideo Kojima | Japan |
| Python, Wolf and Crow | Vengeance | Wai Ka-Fai | Hong Kong, France |
| Quackerjack | Darkwing Duck | Disney | United States |
| Quan Chi | Mortal Kombat franchise | Midway Games | United States |
| Queen Safiyah Sohail aka Safiyah Patel aka Safiyah Nasar | Batwoman | The CW | United States |
| Quentin Glass | The Punisher | Jonathan Hensleigh, Michael France | United States |
| Ray Quick | The Specialist | Alexandra Seros | United States |
| Quiet | Metal Gear franchise | Frank Herbert | Japan |
| Quill | Justice (Marvel's New Universe) | Archie Goodwin | United States |
| Rafferty | Ultraverse | Malibu Comics, Marvel Comics | United States |
| Millia Rage | Guilty Gear | Daisuke Ishiwatari | Japan |
| Rain | Mortal Kombat franchise | Midway Games | United States |
| John Rainbird | Firestarter | Stephen King | United States |
| Reno Raines | Renegade | Stephen J. Cannell | United States |
| Raizo | Ninja Assassin | Matthew Sand, J. Michael Straczynski | United States |
| Josh Randall | Wanted Dead or Alive | CBS Productions | United States |
| Raston Warrior Robot | Doctor Who | Various | United Kingdom |
| Robert Rath | Assassins | The Wachowskis and Brian Helgeland | United States |
| Lord Nelson Rathbone | Shanghai Knights | Alfred Gough, Miles Millar | United States |
| Rattlesnake Jake | Rango | John Logan | United States |
| Ravager | DC Comics | Various | United States |
| Philip Raven | This Gun for Hire | Albert Maltz, W.R. Burnett | United States |
| Ravenous | Marvel Comics | Keith Giffen, Renato Arlem | United States |
| Ray and Ken | In Bruges | Martin McDonagh | United States |
| Ray Shoesmith | Mr Inbetween | Scott Ryan | Australia |
| Rayne | BloodRayne | Terminal Reality | United States |
| Razor Fist | Marvel Comics | Doug Moench, Paul Gulacy | United States |
| Razorclaw | The Transformers | Hasbro | United States |
| Reace | Silver Streak | Colin Higgins | United States |
| Reaper | Overwatch | Blizzard Entertainment | United States |
| Red, aka Rubrum | Arrow | Various | United States |
| Durham Red | 2000 AD | John Wagner, Alan Grant, Carlos Ezquerra | United Kingdom |
| Red Dart | DC Comics | Various | United States |
| Red Daughter ("Krasnaya Doch") aka Snowbird | Supergirl | Various | United States |
| Red Death Mask | Tiger Mask | Ikki Kajiwara, Naoki Tsuji | Japan |
| Red Hood | DC Comics | Various | United States |
| Red Skull | Marvel Comics | France Herron, Jack Kirby, Joe Simon | United States |
| Red Tornado | Supergirl | Various | United States |
| Red Widow | Marvel Comics | Jason Aaron, David Marquez | United States |
| Red X | DC Comics | Various | United States |
| Redhand | The Green Hornet | Phil Hester, Jonathan Ang Lau | United States |
| Robert Montague Renfield | Renfield | Robert Kirkman, Ryan Ridley | United States |
| Reptile | Mortal Kombat franchise | Midway Games | United States |
| Cataleya Restrepo | Colombiana | Luc Besson | United States |
| Emilio Restrepo | Colombiana | Luc Besson | United States |
| Reuban | Real Time | Randall Cole | Canada |
| Ricochet/Fancy Dan | Marvel Comics | Various | United States |
| The Riddler | DC Animated Movie Universe | Various | United States |
| The Riddler | The Batman | Matt Reeves, Peter Craig | United States |
| The Riddler's Cult | The Batman | Matt Reeves, Peter Craig | United States |
| Ridley | Metroid | Makoto Kano | Japan |
| Rience | The Witcher | Andrzej Sapkowski | Poland |
| The Rifle | Batwoman (TV series) | Various | United States |
| The Right Arm aka The Mountain People | The Scorch Trials | James Dashner | United States |
| Ringer | Marvel Comics | David Kraft, Keith Giffen | United States |
| Ringo Roadagain | JoJo's Bizarre Adventure | Hirohiko Araki | Japan |
| Riot | Marvel Comics | David Michelinie, Ron Lim | United States |
| Jackson Rippner | RedEye | Carl Ellsworth, Dan Foos | United States |
| Riptide | Marvel Comics | Chris Claremont, John Romita Jr., Bret Blevins | United States |
| Matthew Risman | Marvel Comics | Craig Kyle, Christopher Yost, Mark Brooks | United States |
| Geralt of Rivia | The Witcher | Andrzej Sapkowski | Poland |
| Roku/Angelina Alcott | Marvel Comics | Valiant Comics | United States |
| Rolo | Code Geass | Gorō Taniguchi, Ichirō Ōkouchi | Japan |
| Ronan the Accuser | Marvel Comics | Stan Lee, Jack Kirby | United States |
| Ruckus (Transformers) | The Transformers | Hasbro | United States |
| Rumor | The Batman | Various | United States |
| Rundas | Metroid Prime 3: Corruption | Andrew Jones | United States |
| Rupture, aka Dante Ramon, aka Reaper | The Flash | Various | United States |
| The Russian | Marvel Comics | Garth Ennis, Steve Dillon | United States |
| John "The Hangman" Ruth | The Hateful Eight | Quentin Tarantino | United States |
| Ryker and Collins | The Replacement Killers | Ken Sanzel | United States |
| Jon Sable | First Comics | Mike Grell | United States |
| Sabretooth | Marvel Comics | Chris Claremont, John Byrne | United States |
| Sagin the Wolf | The Tick | Ben Edlund | United States |
| Sai Cotta | Stark Raven | Endless Horizons Entertainment | United States |
| Saico-Tek | Teen Titans: Trouble in Tokyo | David Slack | United States |
| The Saint of Killers, aka William Munny | Preacher | Garth Ennis, Steve Dillon | United States |
| The Salesman aka The Colonel aka The Man | Sin City | Frank Miller | United States |
| The Sand Snakes | A Song of Ice and Fire | George R. R. Martin | United States |
| The Sand Vipers | London Night Studios | Everette Hartsoe, Tom Sniegoski | United States |
| Sang | Rush Hour | Ross LaManna | United States |
| Santana, Diaz, Vargas, Falco, Nuñez and Luna | Riddick | David Twohy | United States |
| Sarak | Robin of Sherwood | Richard Carpenter | United Kingdom |
| Sardaukar | Dune franchise | Frank Herbert | United States |
| Celaena Sardothien | Throne of Glass | Sarah J. Maas | United States |
| Sawa | Kite | Yasuomi Umetsu | Japan |
| Shuuichi Sawada | Dead or Alive 2: Birds | Masa Nakamura | Japan |
| Mona Sax | Max Payne | Sam Lake | United States |
| Scalphunter | Marvel Comics | Chris Claremont, John Romita Jr. | United States |
| Scarab | DC Comics | Various | United States |
| Francisco Scaramanga aka The Man with the Golden Gun | James Bond | Ian Fleming | United Kingdom |
| Scarecrow | Cyborg 009 | Shotaro Ishinomori | Japan |
| Dr. King Schultz | Django Unchained | Quentin Tarantino | United States |
| Schneider | Schneider vs Bax | Alex van Warmerdam | Netherlands, Belgium |
| Scimitar | Arrow | Various | United States |
| Scorpiana | DC Comics | Various | United States |
| Scorch | Star Wars | George Lucas | United States |
| Scorpion | Mortal Kombat | Midway | United States |
| Scorpion | Ultimate Spider-Man (TV series) | Marvel Animation | United States |
| Scorpion | Spider-Man: Into the Spider-Verse | Marvel Entertainment | United States |
| Scorpion the Grim Ripper | Stark Raven | Endless Horizons Entertainment | United States |
| Scourge of the Underworld | Marvel Comics | Mark Gruenwald, John Byrne | United States |
| Scrambler | Marvel Comics | Chris Claremont, Marc Silvestri | United States |
| Scytale | Dune franchise | Frank Herbert | United States |
| SEAL Team Ricks | Rick and Morty | Justin Roiland and Dan Harmon | United States |
| Colt Seavers | The Fall Guy | Glen A. Larson | United States |
| The Secret Six | DC Comics | Various | United States |
| Sektor | Mortal Kombat franchise | Midway Games | United States |
| The Selkie | Tom Clancy's Net Force | Tom Clancy | United States |
| Sensei | DC Comics | Neal Adams | United States |
| Senyaka | Marvel Comics | Scott Lobdell, John Romita, Jr. | United States |
| Sephiroth | Final Fantasy VII | Tetsuya Nomura, Kazushige Nojima | Japan |
| Sera | Star Trek: New Worlds | David Reed | United States |
| Sergei | Interview with a Hitman | Perry Bhandal | United Kingdom |
| Mr. Shadow | Wicked City | Hideyuki Kikuchi | Japan |
| Shadow Androids | Sonic Heroes | Sega, Sonic Team USA | Japan |
| Shadow Assassins | Mortal Kombat franchise | Midway Games | United States |
| Shadow Company | Lethal Weapon | Shane Black | United States |
| Shadow Knight | Marvel Comics | Doug Moench, Bill Sienkiewicz, Mike Zeck | United States |
| The Shadow Seven | Marvel Comics | Valiant Comics | United States |
| Shadow Viper (Miko Nguyen) | London Night Studios | Everette Hartsoe, Tom Sniegoski | United States |
| Shadow the Hedgehog | Sonic Adventure 2 | Takashi Iizuka, Shiro Maekawa | Japan |
| Shahdee | Prince of Persia: Warrior Within | UbiSoft | France, United States |
| Fennec Shand | Star Wars | Dave Filoni | United States |
| Shang Tsung | Mortal Kombat franchise | Midway Games | United States |
| Shao Kahn | Mortal Kombat franchise | Midway Games | United States |
| Tetrax Shard | Ben 10 | Man of Action | United States |
| Shatterax | Marvel Comics | Len Kaminski, Paul Ryan | United States |
| Sergeant Raymond Shaw | The Manchurian Candidate | Richard Condon | United States |
| Shayes | Mercury Rising | Lawrence Konner, Mark Rosenthal | United States |
| Sheath | Marvel Rising | Christopher Yost, Marcus To | United States |
| Mr. Shhh | Things to Do in Denver When You're Dead | Scott Rosenberg | United States |
| Shin | Fist of the North Star | Buronson, Tetsuo Hara | Japan |
| Shikebaro | Crying Freeman | Kazuo Koike, Ryoichi Ikegami | Japan |
| Shinobi Shaw | Marvel Comics | Jim Lee, Whilce Portacio, Chris Claremont | United States |
| Sayoko Shinozaki | Code Geass | Gorō Taniguchi, Ichirō Ōkouchi | Japan |
| Shocker | Marvel Comics | Stan Lee, John Romita Sr. | United States |
| Shockwave | The Transformers | Hasbro | United States |
| Shredder (Teenage Mutant Ninja Turtles) | Teenage Mutant Ninja Turtles | Mirage Studios | United States |
| Shriek | DC Comics | Various | United States |
| Shuriken, aka Kyoko Shidara | Victory Comics | Reggie Byers | United States |
| Shush | DC Comics | Various | United States |
| SIRKS, aka The Clowns | Skull Man (2007 anime) | Various | Japan |
| Silas | The Da Vinci Code | Dan Brown | United States |
| Silence | The Great Silence | Vittoriano Petrilli, Mario Amendola, Bruno Corbucci, Sergio Corbucci | Italy |
| Silencer, aka Silentum | Arrow | Various | United States |
| Silhouette | Deus Ex | Ion Storm | United States |
| The Silver Monkey | DC Comics | Various | United States |
| Silver Sable | Marvel Comics | Tom DeFalco, Ron Frenz | United States |
| Sin | Marvel Comics | J.M. DeMatteis, Ron Frenz | United States |
| Aurra Sing | Star Wars | George Lucas | United States |
| Sixsix | Ben 10 | Man of Action | United States |
| Lionel Skinner aka Mr. Skinner | 101 Dalmatians | John Hughes | United States |
| Skizm | Stark Raven | Endless Horizons Entertainment | United States |
| The Skull | Scarface | Oliver Stone | United States |
| Skull Face | Metal Gear franchise | Hideo Kojima | Japan |
| Skull Mask | Cyborg 009 | Shotaro Ishinomori | Japan |
| "Skulls" Parasite Unit | Metal Gear franchise | Hideo Kojima | Japan |
| Cade Skywalker | Star Wars | Various | United States |
| Mara Jade Skywalker | Star Wars | George Lucas | United States |
| Slayer | Guilty Gear | Daisuke Ishiwatari | Japan |
| Slaymaster | Marvel Comics | Jim Lawrence, Larry Lieber, Ron Wilson | United States |
| Rum Sleg | Star Wars | George Lucas | United States |
| Slipknot | DC Extended Universe | Various | United States |
| Melvin Smiley, Cisco, Crunch, Vince and Gump | The Big Hit | Ben Ramsey | United States |
| "Mr. Smith" and "Ms. Jones" | Nick of Time | Patrick Sheane Duncan | United States |
| John and Jane Smith | Mr. & Mrs. Smith | Simon Kinberg | United States |
| Smoke | Mortal Kombat franchise | Midway Games | United States |
| Snake | Black Butler | Yana Toboso | Japan |
| Snake | Smallville | Various | United States |
| Snakefinger | Milestone Comics | Various | United States |
| Sniper | Machete | Robert Rodriguez, Álvaro Rodriguez | United States |
| Sniper | Team Fortress 2 | Valve | United States |
| Sniper Wolf | Metal Gear franchise | Hideo Kojima | United States |
| Snowflake | Agents of S.H.I.E.L.D. | Various | United States |
| Sovereign | XCOM: Chimera Squad | Firaxis Games | United States |
| Speed-o'-Sound Sonic | One-Punch Man | One | Japan |
| The Spies | Spy vs. Spy | Antonio Prohías | United States |
| The Spirit Killer | Charmed | Various | United States |
| The Spot | Marvel Comics | Al Milgrom, Herb Trimpe | United States |
| Solid Snake | Metal Gear franchise | Hideo Kojima | United States |
| Sy Snoodles | Star Wars | George Lucas | United States |
| The Sons of the Harpy | A Song of Ice and Fire | George R. R. Martin | United States |
| Spike Spiegel | Cowboy Bebop | Hajime Yatate and Toshihiro Kawamoto | Japan |
| Spire | Metroid Prime Hunters | Andrew Jones and Richard Vorodi | United States |
| Sportsmaster | DC Comics | John Broome, Irwin Hasen | United States |
| Spymaster | Marvel Comics | David Michelinie, Bob Layton | United States |
| Star Clan | Soul Eater | Atsushi Ohkubo | Japan |
| Starkiller | Star Wars | George Lucas | United States |
| Starscream | Transformers: Prime | Various | United States |
| Steve | Mr. Right | Max Landis | United States |
| Steven | The Suicide Theory | Michael J. Kospiah | Australia |
| Erik Stevens aka Killmonger | Marvel Cinematic Universe | Ryan Coogler and Joe Robert Cole | United States |
| Stigmata | Avatar Press | Brian Pulido | United States |
| Rupert Stiltskin alias "The Dwarf" | Foul Play | Colin Higgins | United States |
| Stingrayzor | Stark Raven | Endless Horizons Entertainment | United States |
| Storm Shadow | G.I. Joe | Larry Hama | United States |
| Street Preacher aka Karl Honig | Johnny Mnemonic | William Gibson | United States |
| Strych-9 | The Tenth | Tony Daniel | United States |
| Strych-9's ninjas | The Tenth | Tony Daniel | United States |
| Sub-Zero | Mortal Kombat franchise | Midway Games | United States |
| Michael "Mike" Sullivan Sr | Road To Perdition | Max Allan Collins, Richard Piers Rayner | United States |
| Sully | Commando | Joseph Loeb III, Matthew Weisman, Steven E. de Souza | United States |
| The Swedes | The American | Rowan Joffé | United States |
| Georgia Sykes | Smokin' Aces | Joe Carnahan | United States |
| Sylux | Metroid Prime Hunters | Andrew Jones, Richard Vorodi, and Michael Harrington | United States |
| Suì-Fēng | Bleach | Tite Kubo | Japan |
| T-00/"Mr. X"/"Trenchy"/Tyrant/Super Tyrant (mutated form)/T1/T-103 | Resident Evil franchise | Capcom | Japan |
| T-078/Tyrant | Resident Evil - Code: Veronica | Capcom | Japan |
| T-1000 | Terminator 2: Judgment Day | James Cameron, William Wisher | United States |
| T-1001 | Terminator: The Sarah Connor Chronicles | Josh Friedman | United States |
| T-3000 | Terminator Genisys | Laeta Kalogridis, Patrick Lussier | United States |
| T-5000 aka Skynet aka "Genisys" aka "Skychild" | Terminator Genisys | Laeta Kalogridis, Patrick Lussier | United States |
| T-Ray | Marvel Comics | Joe Kelly, Ed McGuinness | United States |
| T-X aka "Terminatrix" | Terminator 3: Rise of the Machines | John Brancato, Michael Ferris | United States |
| Tabitha Galavan | Gotham | Bruno Heller | United States |
| Takeshi and his team | Ninja Assassin | Matthew Sand, J. Michael Straczynski | United States |
| Talia al Ghul | DC Comics | Dennis O'Neil, Bob Brown | United States |
| Talon | DC Comics | Scott Snyder, Greg Capullo | United States |
| Talon | Overwatch | Blizzard Entertainment | United States |
| Tanaka's Daughter | The Punisher (1989 film) | Boaz Yakin | United States |
| Karl Tanner | Game of Thrones | George R.R. Martin | United States |
| Ken "Nick" Takase/Machineman | Nebula Mask Machineman | Shotaro Ishinomori and Toei | Japan |
| Tanya | Crying Freeman | Kazuo Koike, Ryoichi Ikegami | Japan |
| Tarah | Star Trek: Enterprise | Rick Berman, Brannon Braga | United States |
| Tarantula (Taylor Crossart) | DC Comics | Bert Christman, Gardner Fox | United States |
| Tarantula (Franklin Lester) | DC Comics | Cary Bates | United States |
| Tarantula (Roger Goldman) | DC Comics | Matt Wagner, Guy Davis | United States |
| Tarantula (Catalina Flores) | DC Comics | Devin Grayson | United States |
| Tarantula (Anton Miguel Rodriguez) | Marvel Comics | Gerry Conway, Ross Andru | United States |
| Tarantula (Luis Alvarez) | Marvel Comics | Gerry Conway, Alex Saviuk | United States |
| Tarantula (Miguel Santiago) | Marvel Comics | Stan Lee, Larry Lieber | United States |
| Random Task | Austin Powers | Mike Myers | United States |
| Taskmaster | Marvel Comics | David Michelinie, George Pérez | United States |
| Udai Taxim | Cowboy Bebop | Hajime Yatate | Japan |
| The Terminator aka Cyberdyne Systems Model 101 Series 800 Terminator | The Terminator | James Cameron | United States |
| The Thin Man | Charlie's Angels franchise | Ryan Rowe, Ed Solomon, John August | United States |
| Allan Thompson | The Adventures of Tintin | Hergé | Belgium |
| The Three Blind Mice | James Bond, Dr. No | Eon Productions | United Kingdom |
| Three-Fingered Pete | The Black Adder | Richard Curtis, Rowan Atkinson | United Kingdom |
| Thufir Hawat | Dune franchise | Frank Herbert | United States |
| Tiffany | Spawn | Todd McFarlane, Tony Daniel | United States |
| Tiger Claw aka Takeshi | Teenage Mutant Ninja Turtles | Ciro Nieli, Joshua Sternin, J. R. Ventimilia | United States |
| Timothy | The Long Kiss Goodnight | Shane Black | United States |
| Tira | Soulcalibur franchise | Project Soul | Japan |
| Tleilaxu Face Dancers | Dune franchise | Frank Herbert | United States |
| Duke Togo aka Golgo 13 | Golgo 13 | Takao Saito | Japan |
| Major Arnold Ernst Toht | Raiders of the Lost Ark | Lawrence Kasdan | United States |
| Tora No Shi | Witchblade | Top Cow | United States |
| Trace | Metroid Prime Hunters | Andrew Jones, Richard Vorodi, and Michael Harrington | United States |
| Richard Travers | Cliffhanger | Michael France, Sylvester Stallone | United States |
| Roland Treece | Sony's Spider-Man Universe | Marvel Entertainment | United States |
| Ned Trent | The Specialist | Alexandra Seros | United States |
| Trio | Max Payne | Remedy Entertainment | United States |
| Turles | Dragon Ball Z: The Tree of Might | Takao Koyama | Japan |
| Turles Crusher Corps | Dragon Ball Z: The Tree of Might | Takao Koyama | Japan |
| The Twins | The Matrix Reloaded | The Wachowskis | United States |
| The Twins | Men in Black: International | Art Marcum, Matt Holloway | United States |
| Twisted 3: Kirai, Jihi and Ryuko | The Tenth | Tony Daniel | United States |
| Tyekanik | Children of Dune | Frank Herbert | United States |
| Typhoid Mary | Marvel Comics | Ann Nocenti, John Romita Jr. | United States |
| Valkyrie | Marvel Cinematic Universe | Taika Waititi | United States |
| Asajj Ventress | Star Wars | George Lucas | United States |
| Tommy Vercetti | Grand Theft Auto | Rockstar North | United Kingdom |
| Vicious | Cowboy Bebop | Hajime Yatate | Japan |
| Victor the Cleaner | Point of No Return aka The Assassin | Robert Getchell, Alexandra Seros | United States |
| Viktor | Interview with a Hitman | Perry Bhandal | United Kingdom |
| Villanelle | Killing Eve | Luke Jennings | United Kingdom |
| Vincent | Collateral | Stuart Beattie | United States |
| Vincent Vega and Jules Winnfield | Pulp Fiction | Quentin Tarantino | United States |
| Viper (Madame Hydra) | Marvel Comics | Jim Steranko | United States |
| Tor Vizsla | Star Wars | George Lucas | United States |
| Vitus Dance | Judge Dredd | John Wagner, Alan Grant, Barry Kitson | United Kingdom |
| Vodka | Case Closed franchise | Gosho Aoyama | Japan |
| Pieter Vorstedt | Lethal Weapon 2 | Jeffrey Boam, Shane Black, Warren Murphy | United States |
| Melina Vostokoff | Black Widow | Eric Pearson, Jac Schaeffer, Ned Benson | United States |
| The Waif | Game of Thrones | George R.R. Martin | United States |
| Sarah Walker | Chuck | Josh Schwartz, Chris Fedak | United States |
| Nathan Wallace aka "The Repo Man" | Repo: The Genetic Opera | Terrance Zdunich, Darren Smith | United States |
| Jack Walsh | Midnight Run | George Gallo | United States |
| Warlocks of Qarth | Game of Thrones | George R.R. Martin | United States |
| Major Marquis Warren | The Hateful Eight | Quentin Tarantino | United States |
| Harry Waters | In Bruges | Martin McDonagh | United States |
| Sharice Watters | Smokin' Aces | Joe Carnahan | United States |
| Weapon XI | X-Men Origins: Wolverine | David Benioff and Skip Woods | United States |
| Weavel | Metroid Prime Hunters | Andrew Jones and Richard Vorodi | United States |
| The Weeping Monk | Cursed | Frank Miller and Tom Wheeler | United States |
| Otto West | A Fish Called Wanda | John Cleese, Charles Crichton | United States |
| Mr. White | WildC.A.T.s, Stormwatch | Unknown | United States |
| John Wick | John Wick franchise | Derek Kolstad | United States |
| Widowmaker | Overwatch | Blizzard Entertainment | United States |
| Anna Williams | Tekken | Seiichi Ishii | Japan |
| Nina Williams | Tekken | Seiichi Ishii | Japan |
| Remo Williams | The Destroyer | Warren Murphy, Richard Sapir | United States |
| Victoria "Vicky" Winslow | Red | Jon Hoeber and Erich Hoeber | United States |
| Mr. Wint and Mr. Kidd | James Bond | Ian Fleming | United Kingdom |
| Barb Wire | Comics' Greatest World / Dark Horse Comics | Chris Warner, Team CGW | United States |
| The Wolf | Bullet Train | Kōtarō Isaka | Japan |
| Nicholas D. Wolfwood | Trigun | Yasuhiro Nightow | Japan |
| Sabine Wren | Star Wars | Various | United States |
| Wulfgar, born Heymar Reinhardt | Nighthawks | David Shaber and Paul Sylbert | United States |
| X | Comics' Greatest World / Dark Horse Comics | Steven Grant, Team CGW | United States |
| Yakuza Assassin | Johnny Mnemonic | William Gibson | United States |
| Nie Yinniang | The Assassin | Hou Hsiao-hsien, Chu T'ien-wen, Hsieh Hai-Meng, Ah Cheng | Taiwan, China, Hong Kong |
| 'Yojimbo' the ronin | Machibuse | Kyu Fujiki, Hideo Oguni, Hajime Takaiwa, Ichiro Miyakawa | Japan |
| Seth Youngblood | Marvel Comics | Unknown | United States |
| Zaheer | Avatar: Legend of Korra | Michael Dante DiMartino | United States |
| Zam Wesell | Star Wars | George Lucas | United States |
| The Zahlenschwestern (Vier, Fünf, Sechs, Sieben, Acht and Neun) | Phantom of Inferno | Nitroplus | Japan |
| Zando-Zan Assassins | The Last Starfighter | Jonathan R. Betuel | United States |
| Zarek | Dark-Hunter | Sherrilyn Kenyon | United States |
| Philo Zeiss | DC Comics | Ed Brubaker, Scott McDaniel | United States |
| Zento | Hitman's Wife's Bodyguard | Tom O'Connor | United States |
| Zigesfeld | If Looks Could Kill | Fred Dekker, Darren Star | United States |
| Zuckuss | Star Wars | George Lucas | United States |
| Zwei | Phantom of Inferno | Nitroplus | Japan |
| Ōtomo | RoboCop 3 | Frank Miller and Fred Dekker | United States |
| Nadie | El Cazador de la Bruja | Bee Train, Kōichi Mashimo | Japan |
| Ricardo | El Cazador de la Bruja | Bee Train, Kōichi Mashimo | Japan |