OpenLLM-France/wikimedia huggingface dataset:
# Holocarboxylase synthetase

Holocarboxylase synthetase (biotin—(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)), also known as protein—biotin ligase, is a family of enzymes (EC 6.3.4.10). This enzyme is important for the effective use of biotin, a B vitamin found in foods such as liver, egg yolks, and milk. In many of the body's tissues, holocarboxylase synthetase activates other specific enzymes (called biotin-dependent carboxylases) by attaching biotin to them. These carboxylases are involved in many critical cellular functions, including the production and breakdown of proteins, fats, and carbohydrates.
The catalyzed reaction:
    ATP + biotin + apo-propionyl-CoA:carbon-dioxide ligase (ADP-forming) $\rightleftharpoons$ AMP + diphosphate + propionyl-CoA:carbon-dioxide ligase (ADP-forming)
The 3 substrates of this enzyme are ATP, biotin, and [[apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]], whereas its 3 products are AMP, diphosphate, and propionyl-CoA:carbon-dioxide ligase (ADP-forming).
Holocarboxylase synthetase may also play a role in regulating the activity of genes. In the nucleus, the enzyme likely attaches biotin molecules to histones, which are structural proteins that bind to DNA and give chromosomes their shape. Changing the shape of histones may help determine whether certain genes are turned on or off; however, it is not known how adding biotin affects gene regulation.
The HLCS gene is located on the long (q) arm of chromosome 21 at position 22.1, from base pair 37,045,059 to base pair 37,284,372.

## Related conditions

Holocarboxylase synthetase deficiency: About 30 mutations in the HLCS gene have been identified in people with holocarboxylase synthetase deficiency. Most of these mutations substitute one amino acid (a building block of proteins) for another amino acid in the holocarboxylase synthetase enzyme. Many of the known mutations occur in a region of the enzyme that binds to biotin. These mutations reduce the enzyme's ability to attach biotin to carboxylases and histones. Without biotin, carboxylases remain inactive and are unable to process proteins, fats, and carbohydrates. A lack of holocarboxylase synthetase activity may also alter the regulation of certain genes that are important for normal development. Researchers believe that these disruptions in important cellular functions lead to breathing problems, skin rashes, and the other characteristic signs and symptoms of holocarboxylase synthetase deficiency.
# Hamilton County Fair (Ohio)

The Hamilton County Fair, formerly known as the Carthage Fair, is the county fair of Hamilton County, Ohio. It was held annually by the Hamilton County Agricultural Society at the Hamilton County Fairgrounds in Cincinnati's Carthage neighborhood. It is the oldest county fair in Ohio, first held in 1820 on the Ezekiel Hutchinson farm and beginning in 1855 at the Fairgrounds location. It was the first fair west of the Allegheny Mountains to offer cash awards in livestock competitions. The fair was canceled in 1861 and 1862 due to the American Civil War, in 1917-18 and 1942-44 due to World Wars; in 2018 due to rain and flash flooding, 2020 due to the COVID-19 pandemic, besides 2021-22 until Fall 2023 for multiple reasons, " ... limited availability of vendors, volunteers, and public sanitation and safety equipment, coupled with vendors’ ongoing concerns for public health ...", but was then cancelled due to Hurricane Ian. In the 1970s, the racetrack had to be relocated to make room for Ronald Reagan Cross County Highway's West Side extension. The 2023 fair was held at a new location on McDonald Farm in Sale Creek.
Cincinnati Police and Hamilton County, OH Sheriff's Office, besides security guards, are the fair's patrollers.
# Mittelpöllnitz

Mittelpöllnitz is a municipality in the district Saale-Orla-Kreis, in Thuringia, Germany. The town is a member of the municipal association Triptis.
# Give Them Jesus

"Give Them Jesus" is the lead single by singer-songwriter released in October 2011, from Jaci Velasquez's studio album, Diamond.

## Composition

"Give Them Jesus" is originally in the key of D Major, with a tempo of 102 beats per minute.

## Commercial performance

"Give Them Jesus" peaked at No. 33 on the Billboard Hot Christian Songs chart on January 14, 2012. It spent 20 weeks on the chart.

## Charts

Chart performance for "Give Them Jesus" :
| Chart (2012–13) | Peak position |
| US Christian Songs (Billboard) | 33 |
| US Christian Airplay (Billboard) | 33 |
| US Christian AC (Billboard) | 21 |
# James Honeybone

James Honeybone (born 11 January 1991) is a five times British champion fencer. At the 2012 Summer Olympics, he competed in the Men's sabre, but was defeated in the first round.
He began fencing at the age of 9, and trained in Hungary for two years.
He won the British sabre national title at the British Fencing Championships in 2012, 2013, 2015, 2017 and 2018.
# Jimmy Randall

James Randall (born 1904) was an English professional footballer who played as an outside left.

## Career

Born Ashington, Randall played for Ashington, Bradford City and Derby County. For Bradford City, he made 57 appearances in the Football League; he also made 6 FA Cup appearances.

## Sources

* Frost, Terry (1988). Bradford City A Complete Record 1903-1988. Breedon Books Sport. ISBN 0-907969-38-0.
# Jacqueline Donny

Jacqueline Donny (2 August 1927 – 14 February 2021) was a French model and beauty pageant contestant.

## Career

After being awarded Miss Paris in 1947, she was runner up to that year's Miss France, Yvonne Viseux [fr]. The next year, she became the 18th Miss France, and was crowned Miss Europe 1948.
# Nigel Wright

Nigel Wright may refer to:
* Nigel Wright (boxer) (born 1979), English Boxer
* Nigel Wright (record producer) (born 1955), English record producer
* Nigel Wright (rugby league) (born 1973), English rugby league footballer fl. 1990s and 2000s
* Nigel G. Wright (born 1949), British Baptist theologian
* Nigel S. Wright (born 1963), Canadian businessman and lawyer, former Chief of Staff in the Canadian Prime Minister's Office
* Nigel Wright (musician) (born 1993), American singer-songwriter and musician
* Nigel Wright, perpetrator of the Tesco blackmail plot
# Brian Bullivant

Brian Milton Bullivant (10 February 1927 – 24 November 2013) was a British canoe sprinter who competed in the late 1950s. At the 1956 Summer Olympics in Melbourne, he finished eighth in the K-2 10000 m event and ninth in the K-2 10000 m event.
# Honda CR480

The Honda CR480R is a motocross racing motorcycle, made by Honda in 1982 and 1983.
The bike was a replacement for the earlier Honda CR450, made only in 1981. The '82 had a front drum brake and a four-speed gearbox.The '83 had internally adjustable front forks and a five-speed gearbox.
Danny "Magoo" Chandler rode a CR480 when he won the 1982 ABC Sports Superbikers race, where professional motorcycle racers from various racing disciplines competed on a combination dirt and paved track. and competed in the 1983 race. Racer Steve Wise also won a Superbikers race with a CR480. This race was a precursor to modern Supermoto racing.
The 1982 CR480 had about 52 horsepower and was quite light for its horsepower, at about 226 pounds. Magnesium parts were used for weight saving and the bike had a hand-riveted air-box/air filter housing.
The bike is popular with historic racers that participate in American Historical Motorcycle Racing Association events where competitive classes are run for the various vintage racing classic motorcycles.
# Hamilton County Justice Center

The Hamilton County Justice Center is the main county jail branch for Hamilton County, Ohio. It is serviced by the Hamilton County Sheriff's Office. The facility is located at 1000 Sycamore Street in the central business district of Cincinnati.
The Hamilton County Justice Center was built in 1985 at an expense of $54 million. The complex consists of two brutalist-style twin towers, each of which rise ten floors. The jail twin towers are connected to each other by a windowless skywalk. Direct access to the jail from the Hamilton County Courthouse (across the street) is afforded by another skywalk passing over Sycamore Street.
The jail holds an average 1424 prisoners daily, and an estimated 55,000 annually, giving it the dubious distinction of being one of the 25 largest jails in the U.S.
Several artifacts taken from the Cincinnati Work House and Hospital, a former 19th-century jail, are on display at the Hamilton County Justice Center.
On May 31, 2020, the Hamilton County Sheriff's Department in Cincinnati, Ohio, had an American Flag removed from the justice center and replaced it with a "thin blue line" flag in response to the protests to the murder of George Floyd. It was later reported that the American flag was first stolen, despite images to the contrary. The blue line flag was taken down.
# Bunkobon

In Japan, bunkobon (文庫本) are small-format paperback books, designed to be affordable and space-saving.
The great majority of bunkobon are A6 (105×148mm or 4.1"×5.8") in size. They are sometimes illustrated and like other Japanese paperbacks usually have a dust wrapper over a plain cover. Modern bunkobon can include bestsellers and works of scholarship alike and their pocketbook size make them useful while commuting. They are used for similar purposes as Western mass market paperbacks: generally for cheaper editions of books which have already been published as hardbacks. However, they are typically printed on durable paper and durably bound, and some works are initially published in bunkobon format.
Bunkobon take their name from the publisher Iwanami Shoten, which, in 1927, launched the Iwanami Bunko (Iwanami Library), a series of international works aimed "to bring the classics of new and old, east and west to the broadest possible audience." The original Iwanami Bunko series is credited for transforming books in Japan into affordable, mass-market commodities.
The bunkobon format began to flourish during the late 1920s, following the development of printing technology able to mass-produce cheap books and magazines. During this period, the Japanese industry further developed the bunkobon format based on German Reclam's Universal-Bibliothek book formats.
# Hassan Ahmed (Ghanaian diplomat)

Hassan Ahmed (born 1955) is a Ghanaian diplomat. He has served as Ghana's ambassador to several countries including Iran, Japan and Cuba. He was Head of Office of the UN-AU Hybrid office in Sudan. He is the current Director of Protocol for Nana Akufo-Addo, President of Ghana.

## Working life

Hassan Ahmed graduated with a Master's degree from the Georgetown School of Foreign Service. Much of his working life has been spent as a career diplomat. He was employed at the Ministry of Foreign Affairs of Ghana and worked there for 34 years. He spent time in many countries including Saudi Arabia, Denmark, and Cuba. He was appointed Deputy Chief of Ghana's diplomatic mission in Japan. When President Akuffo-Addo served as Minister of Foreign Affairs under the John Agyekum Kufuor administration, Ahmed was the Chief of Protocol at the Ministry of Foreign Affairs. His last diplomatic posting was to the Islamic Republic of Iran. He served as Ghana Ambassador from 2008 to 2012. After retiring from the Ministry of Foreign of Affairs, he took up an international appointment with the United Nations in 2013. The position was with the United Nations-African Union Hybrid Operation in Darfur, Khartoum, Sudan, where he was appointed the Head of Office.

## Director of Protocol

Hassan Ahmed resigned from his UN position when President Akuffo-Addo appointed him to the position of Head of Protocol at The Flagstaff House. His appointment by the president was well received as many believed that the team that the president had assembled were people of integrity who would help the president to execute his agenda. As Director of State Protocol, Ahmed has the task of arranging all schedules of visits by the President as well as welcoming dignitaries to the presidency. One of such receptions was given to the Chinese Ambassador to Ghana, Her Excellency Sun Baohong, who paid a courtesy call on Ahmed to exchange ideas on how to improve the bilateral relationship between the two countries. He also accompanies the president on overseas trips.

## Personal life

Hassan Ahmed is a Muslim and is married to Hajjia Ahmed with whom he has four children.
# Jeevitha (disambiguation)
## People (given name)

* Jeevitha is an Indian actress concentrating on Tamil and Telugu languages of Indian film industry.
* Jeevitha Panippan, victim of a murder case in Singapore

## Films

* Jeevitham (1950 film), (Telugu: జీవితం; English: Life) is a 1950 Black-and-white Telugu social guidance film produced and directed by A. V. Meiyappan with his company AVM Productions.
* Jeevitha Nouka, (English: The Boat of Life) is a 1951 Malayalam film directed by K. Vembu and jointly produced by K. V. Koshi and Kunchako.
* Jeevitham (1984 film) is a 1984 Indian Malayalam film, directed by K. Vijayan and produced by K. Balaji.
* Jeevitha Chakram (transl. Life Cycle) is a 1971 Telugu-language drama film, produced by P. Gangadhar Rao under the Nava Shakthi Productions banner and directed by C. S. Rao.
* Jeevithe Lassanai, (Life is Beautiful) (ජීවිතේ ලස්සනයි) is a 2012 Sri Lankan Sinhala comedy film directed by Sudesh Wasantha Peris and produced by Sunil T Fernando for Sunil T Films.
* Jeevitham Oru Gaanam is a 1979 Indian Malayalam film, directed by Sreekumaran Thampi.

## TV series

* Jeevitha Nouka (TV series), (English: The Boat of Life) is an Indian Malayalam television series being premiered on Mazhavil Manorama since 23 March 2020.
# James Hong (disambiguation)

James Hong (born 1929) is an American actor.
James Hong may also refer to:
* James Hong, co-founder of the online ratings site Hot or Not
* James T. Hong, Taiwanese-American filmmaker
* James Won-Ki Hong (born 1959), business executive
# Camissonia parvula

Camissonia parvula is a species of evening primrose known by the common name Lewis River suncup. It is native to the Great Basin of the United States. It grows in sagebrush, woodland, and other Great Basin habitat. It is a slender annual herb producing a wiry erect stem 15 to 30 centimeters in maximum height. The leaves are linear in shape and 1 to 3 centimeters long. They are located along the stem as there is no basal rosette. The nodding inflorescence produces flowers with yellow petals only 2 or 3 millimeters long. The fruit is a capsule 2 to 3 centimeters long, swollen with seeds, and sometimes coiling.
# Geophysics (journal)

Geophysics is a bimonthly peer-reviewed scientific journal covering all aspects of research, exploration, and education in applied geophysics. It was established in 1936 and is published by the Society of Exploration Geophysicists. The current editor-in-chief is Jeffrey Shragge (Colorado School of Mines). According to the Journal Citation Reports, the journal has a 2018 impact factor of 2.793.
# Haltota

Haltota is a city located in Western Province, Sri Lanka. It is a legendary city related to the King Raigam Bandara. Postal code of Haltota sub post office is 12538
# Gaza cubana

Gaza cubana is a species of sea snail, a marine gastropod mollusc in the family Margaritidae.

## Description

The size of the shell varies between 23 mm and 37 mm. The pale beige, discoid shell has a weak but marked spiral sculpture. But the first two whorls of the teleoconch have a purple color. The open umbilicus is only sealed for about 75% by the callus of the inner lip. The apex is preserved. The spire is low and flat.

## Distribution

This species occurs in the Caribbean Sea and the Gulf of Mexico at depths between 329 m and 1080 m.
# Improved clinch knot

The improved clinch knot, also known as the Salmon Knot, is a knot that is used for securing a fishing line to the fishing lure, but can also affix fishing line to a swivel, clip, or artificial fly. This is a common knot used by anglers because of its simple tie and strong hold. When more pull is being applied, the harder the knot turns into itself, increasing the strength of the connection. It can be used with many kinds of line including mono-filament, fluorocarbon, and braided fishing line.
# Turan (disambiguation)

Turan is a geographic term referring to certain areas and peoples of Central Asia.
Turan may also refer to:

## Places

* Turan (Baluchistan), a medieval region in Pakistan
* Turan (satrapy), a satrapy of the Sassanid Empire
* Turan, a town in the Drenovë Municipality of southeastern Albania
* Turan, Azerbaijan, a village in Shaki Rayon
* Turan, Iran (disambiguation), places in Iran
* Tur'an, a local council in the North District of Israel
* Turan, Russia, several inhabited localities in Russia
* Turan Range, a mountain range in Russia
* Turan Depression, a desert basin along the Caspian Sea stretching from southern Turkmenistan through Uzbekistan to Kazakhstan
* Turan, alternative name of Fort Terán, a former settlement in Texas, United States

## People

* Turya (Avesta), an ethnic group mentioned in the Avesta after whom the region of Turan is named
* Turan (name), a list of people with the given name or surname
* Turan, alternative name of Toran (Pashtun tribe), a tribe in Afghanistan

## Arts and entertainment

* Turan ensemble, a Kazakh folk music band
* Turan (Conan), a nation in the fictional world of Conan the Barbarian
* Turan Kingdom, a kingdom in Last Exile, a Japanese animated television series

## Businesses

* Turan Air, an Azerbaijani airline
* Turan Corporation, the first company to specialize in Turkish and emerging-market debt
* Turan Information Agency, a news agency based in Baku, Azerbaijan

## Other uses

* Turan (mythology), an Etruscan goddess, roughly equivalent to the Greek Aphrodite and the Roman Venus
* Turán (periodical), a Hungarian journal
* 40M Turán I, a Hungarian tank of World War II
* Turan Tovuz, an Azerbaijani football club based in Tovuz
* FC Turan, a Kazakhstani football club
* Turan University, a private university in Almaty, Kazakhstan
* Turan railway station, a commuter rail station in İzmir, Turkey
* Turan Battalion, a Turkic volunteer battalion of the Ukrainian Armed Forces
# Gerald McKenny

Gerald McKenny is an American theologian, currently the Walter Professor at University of Notre Dame.

## Education

* B.A., Wheaton College (Illinois) 1979
* M.Div., Princeton Theological Seminary, 1982
* Ph.D., University of Chicago, 1989
# CIGB

CIGB can mean:
* Center for Genetic Engineering and Biotechnology (Centro de Ingeniería Genética y Biotecnología), a research institute in Havana, Cuba
* CIGB-FM, a French-language radio station located in Trois-Rivières, Quebec, Canada
# Geopiety

Geopiety is "the belief and worship of powers behind nature or the human environment". It was coined by the American geographer John Kirtland Wright for geographical piety.
The term "geopiety" comes from a combination of the Greek root geo, for earth, and the Latin root "pietas". As Wright explained when coining the term, geopiety is meant to refer to "emotional piety aroused by awareness of terrestrial diversity of the kind of which geography is also a form of awareness".
One example of geopiety can be found in the works of American preacher Jonathan Edwards:
   He that is traveling up a very high mountain, if he goes on climbing, will at length get to that height and eminence as at last not only to have his prospect vastly large, but he will get above clouds and winds, and where he will enjoy a perpetual serenity and calm. This may encourage Christians constantly and steadfastly to climb the Christian hill.
   That high towers or other high places are commonly smitten with thunder, and mountainous places more subject to terrible thunder and lightning, shows how that pride and self-exaltation does particularly excite God's wrath.
# Chronica (Guillaume de Puylaurens)

Cronica (in standard Latin, Chronica; in English, "Chronicle") is the short title of a history of Catharism and the Albigensian Crusade by the 13th century Toulousain author Guillaume de Puylaurens.
The most important manuscript of the Chronica (Paris Bibl. Nat. Latin 5212) dates from the early 14th century. It was probably written in or near Toulouse and perhaps belonged to a Dominican foundation such as Prouille. Two further manuscripts are later copies of this one. A fourth (Paris Bibl. Nat. Latin 5213) is of the 16th century but based on an early manuscript now lost. The 1623 edition by Guillaume Catel (see below) was based on other manuscripts now lost.
The oldest manuscript provides two possible longer titles for the work. The incipit is Incipit chronica a magistro Guillelmo de Podio Laurenti compilata, "here begins the chronicle compiled by Master William of Puylaurens". The prologue is headed Incipit prologus super hystoria negocii a Francis Albiensis vulgariter appellati, "here begins the prologue of the history of what the French call the Albigensian affair".
The chronicle opens with the preaching of Bernard of Clairvaux against the heretics of Verfeil, Haute-Garonne in 1145 and closes with the restitution, on 15 March 1275, of the confiscated lands of Roger-Bernard III of Foix. Work on the chronicle was completed before 25 July 1276, date of the death of James I of Aragon, who is spoken of in the final sentence as still alive.
In the 14th century the Chronica was used by the Dominican historian Bernard Gui, who included long excerpts from it in his Flores chronicorum. An anonymous abbreviation of this latter work was made in the late 15th century under the title Praeclara Francorum facinora; as a popular history this appeared in several undated editions during the first few decades after the spread of printing.
# Gaza compta

Gaza compta is a species of sea snail, a marine gastropod mollusc in the family Margaritidae.

## Description

The size of the shell varies between 23 mm and 28 mm. The pale beige shell has a weak spiral sculpture. But the first two whorls of the teleoconch have a purple color and they show some marked axial undulations.

## Distribution

This species occurs in the Atlantic Ocean off Southeast Brazil at depths between 700 m and 800 m.