# Marina Picciotto

Marina Rachel Picciotto (born June 22, 1963) is an American neuroscientist known for her work on the role of nicotinic acetylcholine receptors in addiction, memory, and reward behaviors. She is the Charles B. G. Murphy Professor of Psychiatry and professor in the Child Study Center and the Departments of Neuroscience and of Pharmacology at the Yale University School of Medicine. She was named Director of the Yale University Interdepartmental Neuroscience Program in September 2023. From 2015 to 2023, she was editor-in-chief of the Journal of Neuroscience. She served as President of the Society for Neuroscience from 2023-2024. She is currently President Elect of the American Association for the Advancement of Science

## Education and early life

Born in Bloomington, Indiana on June 22, 1963, Picciotto moved to New York City as an infant and graduated from Hunter College High School in 1981. Picciotto received her B.S. in biology from Stanford University in 1985, and her Ph.D. in 1992 from Rockefeller University. She carried out post-doctoral work at the Pasteur Institute in Paris from 1992-1995.

## Scientific career

Picciotto began her career in neuroscience as an undergraduate researcher at Stanford University, where she worked with Richard Scheller. There she discovered that the FMRFamide gene gives rise to multiple copies of the neuropeptide. She went on to PhD work with Paul Greengard at Rockefeller University where she cloned the gene for calcium/calmodulin-dependent protein kinase 1 As a Human Frontier Science Program postdoctoral fellow with Jean-Pierre Changeux at the Pasteur Institute in Paris, Picciotto produced the first mouse knock-out lacking a nicotinic receptor subunit. She returned to the United States in 1995 to join the Yale University faculty as an assistant professor and rising through the ranks to become the Charles B.G. Murphy Professor in Psychiatry in 2008. Her group is known for its discoveries in nicotine addiction and brain circuits. Recent work from Picciotto showed that pre-natal exposure to nicotine has profound effects on adult behavior. In press interviews, she has expressed concerns about the use of e-cigarettes and low-dose nicotine cigarettes.

## Editorial

In 2015, Picciotto was named editor-in-chief of The Journal of Neuroscience. After taking over leadership at the journal, she instituted a number of changes including eliminating submission fees for Society for Neuroscience members and restoring the ability of authors to publish supplementary data alongside their papers. Picciotto has also instituted new controls on statistical analysis and experimental design reporting. In a move to support pre-print publishing, Picciotto added The Journal of Neuroscience to the list of journals that will accept submissions directly from bioRxiv. She also started initiatives on social media to thank scientists who participated in peer review at the journal.

## Awards

President Bill Clinton presented Picciotto with the Presidential Early Career Award for Scientists and Engineers at the White House in 2000. She received the Jacob P. Waletzky Memorial Award for Innovative Research in Drug Addiction and Alcohol Research from The Society for Neuroscience in 2007. Picciotto was elected as an AAAS fellow of the American Association for the Advancement of Science in 2014, and was elected to the National Academy of Medicine in 2012. Picciotto was elected President of the Society for Research on Nicotine and Tobacco, for the 2018-19 term. In 2019, Picciotto was among 11 scientists awarded the National Institutes of Health’s Pioneer Award. That same year, she was awarded the Bernice Grafstein award for advancing the careers of women in neuroscience. She received the Andrew Carnegie Prize for Mind and Brain Science in 2020 and she was awarded the Langley Award for Basic Research on Nicotine and Tobacco in 2021. Picciotto was inducted into the American Academy of Arts and Sciences in 2024 for her work in the field of neuroscience.

## Selected publications

* Zhou, W.-L., Kim, K., Ali, F., Pittenger, S. T., Calarco, C. A., Mineur, Y. S., Ramakrishnan, C., Deisseroth, K., Kwan, A. C., & Picciotto M. R. (2022). "Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward". Science Advances. 8 (42): eabm5217. Bibcode:2022SciA....8M5217Z. doi:10.1126/sciadv.abm5217. PMC 9581470. PMID 36260661.{{cite journal}}: CS1 maint: multiple names: authors list (link)
* Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., Le Novère, N., Vincent, P., Merlo Pich, E., Brulet, P. & Changeux, J.-P. (1995). "Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain". Nature. 374 (6517): 65–67. Bibcode:1995Natur.374...65P. doi:10.1038/374065a0. PMID 7870173. S2CID 4303990.{{cite journal}}: CS1 maint: multiple names: authors list (link)
* Picciotto, M. R., Czernik, A. & Nairn, A. C. (1993). "Calcium/calmodulin-dependent protein kinase I - cDNA cloning and identification of autophosphorylation site". J. Biol. Chem. 268 (35): 26512–26521. doi:10.1016/S0021-9258(19)74343-9. PMID 8253780.{{cite journal}}: CS1 maint: multiple names: authors list (link)
* Schaefer, M., Picciotto, M. R., Kreiner, T., Kaldany, R., Taussig, R. & Scheller, R. H. (1985). "Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides". Cell. 41 (2): 457–461. doi:10.1016/S0092-8674(85)80019-2. PMID 3838698. S2CID 22684178.{{cite journal}}: CS1 maint: multiple names: authors list (link)