# List of defunct airlines of the United States (A–C)

The following is a list of defunct airlines of the United States. However, some of these airlines have ceased operations completely, changed identities and/or FAA certificates and are still operating under a different name (e.g. America West Airlines changed to use the identity of US Airways in 2005 – which itself also changed identity to American Airlines in 2015).
For reasons of size, this article is broken into four parts:
* List of defunct airlines of the United States (A–C)
* List of defunct airlines of the United States (D–I)
* List of defunct airlines of the United States (J–P)
* List of defunct airlines of the United States (Q–Z)
* 0–9
* A
* B
* C
* See also
* References
| Airline | State or territory | Image | IATA | ICAO | Callsign | Hubs and focus cities | Commenced operations | Ceased operations | Notes |
| 0–9 ||||||||||
| 135 Airlines | Texas | | | GNL | | Dallas Love Field | 1995 | 1995 | |
| 4 W Air | Alaska | | | | | King Salmon | 2003 | 2003 | |
| A ||||||||||
| AAA Air Enterprises | Nebraska | | | | | Eppley Airfield | 1977 | 1986 | Acquired by Mid-Continent Airlines |
| AAI Alaska Aeronautical Industries | Alaska | | YC | ALR | | Anchorage | 1954 | 1987 | Agreement with Continental Airlines |
| AAXICO Airlines | Florida | | | | | Miami | 1946 | 1965 | Acquired by Saturn Airways, w/ AAXICO the surviving management and ownership. |
| Abbe Air Cargo | Alaska | | | | | Wasilla | 2001 | 2003 | Operated C-47 |
| ABC Airlines | California | | | | | Ontario | 1965 | 1966 | |
| Absaroka Airways | Montana | | | | | Red Lodge | 1994 | 2012 | Scenic flights around the Beartooth Mountains. Operated Cessna 172 |
| ACA Aviation Corporation of the Americas | Alaska | | | | | Anchorage | 1927 | 1932 | Founded by Juan Trippe |
| Academy Airlines | Georgia | | | ACD | ACADEMY | Atlanta | 1979 | 2006 | |
| AccessAir | Iowa | | ZA | CYD | CYCLONE | Des Moines | 1998 | 2001 | |
| Ace Air Cargo Express | Ohio | | CG | AER | | Cleveland Hopkins | 1976 | 1982 | Renamed to Shalkow Air Cargo Express. Operated C-47 |
| Ace Airways | Massachusetts | | | | | | 1965 | 1971 | Operated Beech D18S |
| Ace Aviation | Maine | | | | | | 1979 | 2000 | Air charter service |
| ACM Aviation | California | | | BJT | BAYJET | San Jose | ? | 2010 | Acquired by TWC Aviation |
| Action Airlines | Connecticut | | XQ | AXQ | ACTION AIR | Goodspeed | 1979 | 2000 | |
| Active Aero Charter | Michigan | | | AVR | ACTIVE AERO | Willow Run | 1999 | 2000 | |
| ADI Aerodynamics | Michigan | | 4A | DYN | AERODYNAMICS | Oakland Pontiac | 2011 | 2018 | Acquired by California Pacific Airlines. Operated Embraer ERJ 145 |
| ADI Domestic Airlines | Illinois | | | C14 | | Chicago O'Hare | 1992 | 1998 | |
| Adirondack Airlines | New York | | | | | Adirondack | 1991 | 1991 | |
| Admiral Airways | California | | | | | Burbank | 1961 | 1962 | Supplemental air carrier. Originally Quaker City Airways. CAB refused to certificate the airline in 1962 due to combine activities. |
| Admiralty Air | Florida | | | | | Palm Beach | 2009 | 2017 | Operated Embraer ERJ-135 |
| Ads-Aloft | Washington | | | | | Seattle | 1994 | 1995 | Banner towing company |
| Advanced Air Management | California | | | | | Burbank | 2000 | 2015 | Renamed to Zetta Jet |
| Adventure Airlines | Nevada | | | | | Las Vegas McCarran | 1995 | 1996 | |
| Adventure Aviation | Idaho | | | | | Coeur d'Alene | 1995 | 1995 | Scenic flights |
| Aerial Transit Company | Florida | | | AEZ | AERIAL TRANZ | Miami | 1982 | 1994 | Sold to Southeast Cargo Airlines in 1994. Operated 707, DC-6 |
| Aerie Airlines | Tennessee | | | | | Clarksville–Montgomery | 1971 | 1979 | |
| Aero Coach | Florida | | DF | DFA | AEROCOACH | Fort Lauderdale | 1983 | 1991 | Operated Cessna 402, Embraer Bandeirante |
| Aero Commuter | California | | | | | Long Beach | 1967 | 1969 | Merged with Cable Commuter Airlines and Catalina Airlines |
| Aero Contractors | North Carolina | | | | Smithfield | | 1979 | 2006 | Charter carrier that provided flights for CIA |
| Aero Corporation of California | California | | | | | Los Angeles | 1926 | 1930 | Operated Universal Aircraft |
| Aero Flight Services | Florida | | | | | Fort Lauderdale | 1976 | 2000 | Operated Hawker 400A, Learjet 23, Learjet 25 |
| Aero Limited | Florida | | | | | Miami | 1919 | 1919 | Acquired by Aeromarine Sightseeing and Navigation Company |
| Aero Taxi Rockford | Illinois | | | | | Chicago Rockford | 1998 | 2001 | Cargo carrier |
| Aero Union | California | | | | | Chico | 1960 | 2011 | Lost federal firefighting contract as a result of the U.S. Forest Service airtanker scandal. |
| Aero Virgin Islands | Virgin Islands | | | | | St. Thomas | 1977 | 1990 | |
| Aero West Airlines | Colorado | | | | | Colorado Springs | 1982 | 1982 | Acquired the assets of Royal West Airlines. Operated DC-3 |
| Aeroamerica | Washington | | EO | AEO | AEROAMERICA | Seattle Berlin Tegel | 1973 | 1982 | Uncertificated carrier |
| Aerocosta | Florida | | | | | Miami | 1972 | 1972 | Cargo carrier |
| Aerodynamics Inc. | Georgia | | 4A | DYN | AERODYNAMICS | Denver | 1959 | 2018 | Acquired by California Pacific Airlines. |
| Aeroflex Corporation | New Jersey | | | | | Aeroflex–Andover | 1958 | 1971 | Operated Beech E18S, Beech Bonanza, Hiller UH-12 |
| Aerolaska | Alaska | | | | | | 1982 | 1986 | |
| Aeromarine Airways | Florida | | | | | Key West | 1921 | 1924 | Operated Felixstowe F5L flying boat |
| Aeromarine West Indies Airways | Florida | | | | | Biscayne Bay | 1920 | 1924 | Formed by a merger between Florida West Indies Airways and Aeromarine Sightseeing and Navigation Company. Reorganized as Aeromarine Airways |
| Aeromech Airlines | West Virginia | | KC | RZZ | AEROMECH | North Central West Virginia Airport | 1951 | 1983 | Merged into Wright Airlines |
| Aeronaut Air Services | Mississippi | | | | | Gulfport-Biloxi | 1966 | 1966 | Operated DC-3 |
| Aerostar Airlines | Georgia | | | | | Atlanta | 1981 | 1983 | Went bankrupt and sold to Flight International Airlines. Operated Boeing 727 |
| Aerosun International | Florida | | | ASI | AEROSUN | Miami | 1978 | 1982 | Established as Red Carpet Airlines. Operated Convair 440, DC-3 |
| Aerovias Sud Americana | Florida | | JI | JI | | St Petersburg | 1947 | 1965 | Scheduled freight operator from Florida to Latin America. |
| AEX Air | Arizona | | | DST | DESERT | Phoenix Sky Harbor | 2004 | 2006 | Charter operator |
| aha! | Nevada | | EV | ASQ | ACEY | Reno-Tahoe | 2021 | 2022 | Commenced operations as ExpressJet in 1987. Announced liquidation in 2022. |
| Aho Flying Service | Alaska | | | | | Anchorage | 1930 | 1930 | |
| Air 1 | Missouri | | CB | AON | GATEWAY | St. Louis Lambert | 1983 | 1985 | Operated Boeing 727, Jetstream 31 |
| Air Alaska Cargo | Washington | | 8S | | | Spokane | 1986 | 1998 | Began as Salair |
| Air America | | | | | | | | 1954 | Irregular air carrier shut in 1954 by CAB for flying scheduled service |
| Air America | District of Columbia | | GM | AMR | AIR AMERICA | Saigon Vientiane Udorn | 1950 | 1976 | Founded by Claire Lee Chennault as Civil Air Transport. Operated by the CIA |
| Air America | California | | GM | AMR | | Los Angeles | 1989 | 1990 | Established as Total Air in 1984 |
| Air Americana | Florida | | | | | Tampa | 1965 | 1981 | Established as Aerovias Sud Americana in 1947. Operated DC-3, Lockheed L-1649 |
| Air Astro | California | | | | | Los Angeles | 1968 | 1971 | Operated Carstedt Jet Liner 600 |
| Air Atlanta | Georgia | | CC | CRB | AIRLAN | Atlanta | 1984 | 1987 | |
| Air Aurora | Illinois | | AX | AAI | | Aurora | 1977 | 2000 | Air taxi operator |
| Air Bahia | California | | | | | San Diego | 1979 | 1980 | |
| Air Bama | Alabama | | | ABI | | Montgomery | 1978 | 1984 | Operated Beech 18, HP Jetstream |
| Air Berlin USA | | | AB | BER | AIR BERLIN | Berlin Tegel | 1978 | 1992 | Reconstituted as Air Berlin GmbH & Co. Luftverkehrs KG in 1990 under German company law. |
| Air California | California | | OC | ACL | AIRCAL | Orange County | 1967 | 1987 | Merged into American Airlines. |
| Air Cargo Express | Alaska | | 3K | FXG | CARGO EXPRESS | Fairbanks | 1995 | 1995 | |
| Air Cargo Hawaii | Hawaii | | | | | Honolulu | 1977 | 1992 | Established in 1973 as Air Distribution. Operated Shorts Skyvan |
| Air Cargo Masters | South Dakota | | | | | Sioux Falls | 1995 | 2006 | Operated Beech 1900, Beech Queen Air, SA227 |
| Air Cargo Transport | New Jersey | | | | | Newark | 1945 | 1948 | Operated C-47 |
| Air Caribbean | Puerto Rico | | | | | San Juan | 1975 | 1979 | |
| Air Carolina | South Carolina | | FN | | | Florence | 1967 | 1980 | Established as Florence Airlines. Absorbed by Atlantis Airlines. |
| Air Carriers | Alabama | | | FCI | | Chilton County | 1989 | 2003 | Operated Cessna 208 Caravan |
| Air Carriers Express Services | Georgia | | | | | Atlanta | 1985 | 1985 | Operated Cessna 208 Caravan |
| Air Catalina | California | | | | | Catalina | 1965 | 1976 | Founded as Catalina Channel Airlines |
| Air Central | Minnesota | | | | | Minneapolis–Saint Paul | 1972 | 1973 | Operated Cessnas |
| Air Central | Oklahoma | | | | | Enid Woodring | 1978 | 1980 | Renamed to Trans-Central Airlines. Operated Piper Chieftain |
| Air Central | Texas | | | ACS | AIR CENTRAL | Harlingen | 1978 | 1979 | |
| Air Chaparral | Nevada | | | MAV | MAVERICK | Reno–Tahoe | 1980 | 1983 | |
| Air Charter Service | California | | | | | Riverside | 1968 | 1972 | Operated Beech Bonanza, Cessna 150 |
| Air Charter West | | | | | | | 1974 | 1977 | |
| Air Chicago | Illinois | | | | | Chicago Midway | 1981 | 1982 | |
| Air Chico | California | | | | | Chico | 1980 | 1982 | |
| Air Choice One | Missouri | | 3E | WBR | WEBER | St. Louis | 1979 | 2022 | Transferred to the Southern Airways Express brand. |
| Air Colorado | Colorado | | | TAC | | Denver | 1980 | 1981 | |
| Air Commuter Airlines | Ohio | | | | | Cleveland Burke | 1967 | 1968 | Merged with Wright Airlines |
| Air Continental | Ohio | | | NAR | NIGHT AIR | Cleveland Hopkins | 1979 | 1989 | Acquired by US Check Airlines. Operated Learjet 23 |
| Air Contract Cargo | Michigan | | | | | Oakland County | 1983 | 1992 | To Gulf and Caribbean Cargo |
| Air Cortez | California | | AB | ACI | AIR CORTEZ | Ontario | 1977 | 1986 | |
| Air Distribution | Hawaii | | | | | Honolulu | 1973 | 1975 | To Air Cargo Hawaii. Operated Shorts Skyvan |
| Air East | Pennsylvania | | | | | Johnstown–Cambria | 1967 | 1974 | |
| Air East | Texas | | | | | Scholes–Galveston | 1969 | 1971 | Established as Aerosmith Airlines |
| Air East Airlines | Louisiana | | | | | Lafayette | 1970 | 1980 | Connected to New Orleans |
| Air Enterprises | West Virginia | | | | | Huntington Tri-State | 1969 | 1971 | Renamed to Tri-State Flying Service |
| Air Excursions | Alaska | | | | | Gustavus | 2013 | 2013 | Founded by Steve Wilson. To Alaska Seaplane |
| Air Exec Ontario | California | | | | | Ontario | 1981 | 1985 | Operated DC-3 |
| Air Express | Colorado | | | | | Denver | 1932 | | |
| Air Ferries | California | | | | | Alameda | 1930 | 1933 | Connected to San Francisco and Oakland |
| Air Florida | Florida | | QH | FLA | PALM | Miami | 1971 | 1984 | Air Florida Commuter was an affiliate |
| Air Florida Commuter | Florida | | QH | FLA | PALM | Miami | 1980 | 1984 | Air Florida Commuter was an affiliate |
| Air Hawaii | Hawaii | | HP | | | Honolulu | 1977 | 1983 | Founded by Bruce McKenzie by a merger with Island Pacific Air and Air Molokai |
| Air Hawaii | Hawaii | | XK | AHC | AIR HAWAII | Honolulu | 1985 | 1986 | |
| Air Hemet | California | | | | | Hemet-Ryan | 1964 | 1984 | Connected to desert cities with Los Angeles |
| Air Holiday International | Wisconsin | | | | | Milwaukee | 1973 | 1977 | Owned by Robert W. Larson. |
| Air Idaho | Idaho | | | | | Twin Falls | 1974 | 1975 | Founded as Trans Magic Airlines |
| Air Illinois | Illinois | | UX | AIL | AIR ILLINOIS | Springfield–Branson | 1970 | 1984 | |
| Air Indiana | Indiana | | | | | Evansville | | | |
| Air Iowa | Iowa | | | | | Muscatine | 1971 | 1974 | Operated Beech 18 |
| Air Irvine | California | | | | | Orange County | 1982 | 1983 | Acquired by Dash Air |
| Air Juneau | Alaska | | | | | Juneau | 2001 | 2001 | |
| Air Kentucky | Kentucky | | KN | AKY | AIR KENTUCKY | Owensboro–Daviess | 1970 | 1989 | Commenced operations in 1974. |
| Air Ketchum | Idaho | | L3 | | | Hailey | 1999 | 2000 | Operated Beech King Air |
| Air L.A. | California | | UE | UED | | Los Angeles | 1982 | 1995 | Purchased Conquest Airlines. |
| Air Lincoln | Illinois | | | ALN | CHICAGO LINCOLN | Chicago Midway | 1982 | 1982 | |
| Air Link Airlines | Colorado | | | LNK | AIR LINK | Denver | 1981 | 1984 | Founded as Valley Airpark. Acquired by Fort Collins Flying Service in 1981. |
| Air Link Airways | Texas | | | | | Houston Bush | 1986 | 1988 | |
| Air Marc | New York | | | | | New York Kennedy | 1984 | 1985 | Founded as Eastman Airways. |
| Air Metro Airlines | Michigan | | DZ | | | Traverse City | 1975 | 1976 | Operated Beech 99 |
| Air Miami | Florida | | VW | | | Miami | 1977 | 1980 | Renamed to North American Airlines. Operated CASA 212 |
| Air Michigan | Michigan | | | | | Kalamazoo | 1969 | 1972 | Operated Beech 99, Twin Otter, Cessna 310 |
| Air Mid-America Airlines | Illinois | | | | | Chicago Meigs Field | 1969 | 1970 | Operated DC-3 |
| Air Midway | Nebraska | | | | | Kearney | 1992 | 1994 | Founded by Clyde Mikelson. Operated Cessna 185, Piper Aztec |
| Air Midwest | Kansas | | ZV | AMW | AIR MIDWEST | Kansas City | 1965 | 2008 | Commenced operations in 1967. |
| Air Missouri | Michigan | | BF | | | Kirksville | 1976 | 1978 | Established as Horizon Airways. Operated Cessna 207 |
| Air Molokai | Hawaii | | | | | Honolulu | 1985 | 1988 | Founded as Tropic Airlines |
| Air National | | | 6A | ANE | AIR TARA | | 1981 | 1984 | |
| Air Nebraska | Nebraska | | | | | Kearney | 1976 | 1981 | Operated Cessna 402, Piper Navajo |
| Air Nevada | California | | | | | Los Angeles | 1969 | 1970 | Established as Hawthorne-Nevada Airlines. Operated DC-3 |
| Air Nevada | Nevada | | | ANV | AIR NEVADA | Las Vegas McCarran | 1974 | 1998 | |
| Air New England | Massachusetts | | NE | | | Boston | 1970 | 1981 | |
| Air New Mexico | New Mexico | | | | | Las Cruces | 1980 | 1980 | Founded as Zia Airlines |
| Air New-Mexico | New Mexico | | | | | | 1961 | 1964 | |
| Air New Orleans | Alabama | | NT | ANL | AIR NEW ORLEANS | Birmingham–Shuttlesworth | 1981 | 1988 | |
| Air New Ulm | Minnesota | | | | | New Ulm | 1973 | 1977 | Renamed to Lake State Airways |
| Air Newark Inc. | New Jersey | | 2N | NER | NEWAIR | Fort Lee | 1961 | 1964 | |
| Air Niagara | New York | | NA | | | Niagara Falls | 1978 | 1984 | |
| Air North | Vermont | | NO | ANO | AIR NORTH | Burlington | 1963 | 1988 | Established as Northern Airways. Contract for Allegheny Commuter in 1970. Acquired by Brockway Air in 1983. |
| Air North | Alaska | | | | | Fairbanks | 1982 | 1984 | |
| Air O'Hare | Illinois | | | | | Chicago O'Hare | 1974 | 1975 | Operated C-47AQ Skytrain |
| Air Oasis | California | | | | | | 1962 | 1964 | Operated DC-3 |
| Air Olympia | Washington | | | | | Olympia | 1981 | 1982 | |
| Air Oregon | Oregon | | JT | | AIR OREGON | Portland | 1978 | 1981 | Merged with Horizon Air. |
| Air Pac | Alaska | | 5P | APM | ALASKA PACIFIC | Dutch Harbor | 1982 | 1986 | Renamed to Air Pacific |
| Air Pacific | California | | IK | | | Oakland | 1970 | 1981 | Founded as Eureka Aero. Merged with Gem State Airlines to form Golden Gate Airlines. |
| Air Pennsylvania | Pennsylvania | | | | | Reading | 1976 | 1982 | |
| Air Rajneesh | Oregon | | | | | Big Muddy Ranch | 1985 | 1985 | Operated Convair 240 |
| Air Resorts | California | | UZ | ARZ | AIR RESORTS | McClellan–Palomar | 1975 | 1996 | |
| Air Response North | New York | | | RPS | | New York-LaGuardia | 1986 | 2003 | Renamed to Global Air Response. Operated Learjet 24, Learjet 25, Learjet 35 |
| Air San Juan | Washington | | | | | Friday Harbor | 1990 | 1991 | Founded as ChartAir |
| Air Sedona | Arizona | | | | | Sedona | 1983 | 1988 | |
| Air Services | | | | | | | | 1959 | Supplemental air carrier shut by CAB in 1959 for combine activities |
| Air Shamrock | | | | | | | 1999 | 2007 | |
| Air Shannon | Virginia | | | | | Washington National | 1966 | 1967 | |
| Air South (Florida) | Florida | https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcSIcCJgqst_P_XUGzMDSc01dF43IPxOJPoMh48n5aK1Lg&s | GD | | SHAWNEE | Miami Homestead | 1986 | 1987 | Operated Trislander. Owner previously associated with Shawnee Airlines, Bahamas Caribbean Airline, Aero International, Bahamas Air Bridge and Argosy Airlines |
| Air South (Georgia) | Georgia | | | | | Atlanta | 1969 | 1978 | Founded as Nationwide Airlines Southeast. Acquired by Florida Airlines in 1975. |
| Air South (South Carolina) | South Carolina | | WV | KKB | KHAKI BLUE | Columbia (SC) | 1993 | 1997 | Commenced operations in 1994. |
| Air Spirit | Texas | | | SIP | AIR SPIRIT | Dallas Love Field | 1981 | 1984 | Founded as Cen-Tex Airlines. Operated Embraer Bandeirante |
| Air St. Thomas | Virgin Islands | | ZP | SST | | St. Thomas | 1975 | 2005 | |
| Air Sunshine | Florida | | AG | AAT | | Miami | 1974 | 1979 | Founded as American Air Taxi in 1972. Absorbed by Air Florida |
| Air Tahoma | Ohio | | | HMA | TAHOMA | Columbus | 1995 | 2009 | |
| Air Taos | New Mexico | | | | | Taos | 1977 | 1979 | |
| Air Taxi | South Carolina | | | | | Florence | 1969 | 1969 | Renamed Florence Airlines |
| Air Texana | Texas | | | | | Lufkin | 1980 | 1981 | |
| Air Traders International | California | | | | | Los Angeles | 1980 | 1980 | Operated 2 L-1049 Super Constellation |
| Air Traffic Service | | | | | | | 1972 | 1980 | |
| Air Trails | California | | | | | Salinas | 1960 | 1999 | Renamed Million Air Monterey. Operated Beech King Air, Cessna 310, Cessna 550 |
| Air Train | California | | | | | San Jose | 1983 | 1989 | Was a Part 204 commuter air carrier |
| Air Transit | Arizona | | | | | Show Low | 1959 | 1968 | |
| Air Transport Associates | Washington | | | | | Seattle | 1948 | 1953 | Irregular air carrier shut by the CAB in 1953 for flying scheduled service. |
| Air Transport Services | Alaska | | | | | Kodiak | 1984 | 1988 | Acquired by PenAir |
| Air Travel | California | | | | | Oakland | 1946 | 1947 | Original name of Overseas National Airways. Became Calasia Air Transport in 1947 |
| Air Trine | Florida | | | | | Miami | 1976 | 1977 | Operated Convair 880 |
| Air U.S. | Wyoming Colorado | | | | | Riverton Denver | 1978 | 1984 | Renamed Excellair |
| Air Vectors Airways | New York | | | | | Newburgh | 1979 | 1985 | Founded by Jim Aspin. Contract carrier for FedEx. |
| Air Vegas | Nevada | | 6V | VGA | AIR VEGAS | North Las Vegas | 1971 | 2004 | |
| Air Vermont | Vermont | | MU | VER | AIR VERMONT | Burlington | 1981 | 1984 | |
| Air Virginia | Virginia | | CE | FVA | AIR VIRGINIA | Lynchburg | 1979 | 1988 | Established as Cardinal Airlines. Renamed AVAir in 1985 |
| Air-Lift Commuter | North Carolina | | 3L | WPK | | Raleigh Durham | 1976 | 1988 | Operated Fairchild Swearingen Metroliner |
| Air-Speed | Massachusetts | | | | | Hanscom Field | 1974 | 1980 | Operated Beech 99, Piper Cherokee |
| Air21 | California | | A7 | UBA | ROCKETEER | Fresno Yosemite | 1995 | 1997 | Operated Fokker F-28, bankrupt |
| Airborne Express | Washington | | GB | ABX | ABEX | Seattle–Tacoma | 1946 | 2003 | Founded as Airborne Flower Traffic Association of California. Merged with Airborne Freight to form ABX Air. |
| Airbourne Freight Company | Ohio | | | | | Wilmington | 1968 | 1980 | Renamed Airborne Express |
| Airborne Transport | Florida | | | | | Miami | 1948 | 1948 | Operated Douglas DST-144 |
| Aircharters World | | | | WFT | WORLD FLIGHT | | 1994 | 1994 | Charter carrier |
| AirCal | California | | OC | ACL | AIRCAL | Orange County | 1981 | 1987 | Established as Air California |
| Aircraft Pool Leasing Corporation | Florida | | | | | Miami | 1973 | ? | Operated L-1049 Super Constellation |
| AirExec | Maryland | | | | | Ocean City | 1973 | 1975 | Operated Twin Otter |
| Airgo Air Freight | Texas | | | | | Dallas Love Field | 1977 | 1981 | Operated Vickers Viscount, DC-3, Convair 440 |
| Airlift International | Florida | | RD | AIR | AIRLIFT | Miami | 1945 | 1991 | Founded as Riddle Airlines |
| Airline Transport Carriers | California | | | | | Burbank | 1946 | 1962 | Irregular air carrier dba California Hawaiian, sister airline to California Central |
| Airmark Aviation | | | | TRH | TRANSTAR | | 1991 | 1993 | Renamed Transtar Airlines |
| Airmark Corporation | | | | MRC | AIRMARC | | 1983 | 1985 | VIP charters carrier |
| AirNow | Vermont | | | RLR | RATTLER | Bennington | 1957 | 2011 | Established as Business Air |
| AirOne | | | K3 | QTN | | | 1998 | 2002 | |
| Airpac | Alaska | | | APM | ALASKA PACIFIC | | 1978 | 1986 | |
| Airplane Charter by Mercer | | | | | | Hollywood Burbank | 1945 | 1949 | Irregular air carrier, renamed Associated Airways in 1949. |
| Airship Airways | | | | | | Fort Lauderdale-Hollywood | 1998 | 2000 | Renamed Planet Airways |
| Airship Ventures | California | | | | | Moffett Federal Airfield | 2008 | 2012 | |
| AirSpur | California | | OT | ASU | SPUR EXPRESS | Los Angeles | 1981 | 1985 | Acquired by Evergreen International Airlines |
| AirTrain Airlines | Pennsylvania | | | | | Pittsburgh | 1993 | 1995 | Renamed Jettrain in 1996 |
| AirTran Airways | Florida | | FL | TRS | CITRUS | Orlando | 1992 | 2014 | Merged into Southwest Airlines |
| AirTran JetConnect | Georgia | | FL | TRS | CITRUS | Atlanta | 2002 | 2004 | |
| AirVantage Airlines | Minnesota | | 3N | AVV | AIRVANTAGE | St. Paul Downtown | 1981 | 1997 | |
| Airvia Transportation Company | New York | | | | | New York City | 1929 | 1929 | Operated Savoia-Marchetti S.55 |
| Airways International | Florida | | 4A | AWB | AIRNAT | Miami | 1981 | 1999 | |
| Airways of New Mexico | New Mexico | | | ANM | AIR NEW MEXICO | | 1977 | 1984 | |
| Aladdin Air Services | Utah | | | | | Panguitch | 1996 | 2001 | |
| Alair | Alabama | | KB | | | Anniston | 1977 | 1979 | |
| Alamo Jet | Alabama | | KB | | | Stinson | 1992 | 1998 | Charter carrier |
| Alaska Aerial Transportation Company | Alaska | | | | | | 1924 | 1924 | |
| Alaska Air Taxi | Alaska | | | | | | 1995 | 2006 | Operated Texas Turbines Super Otter |
| Alaska Air Transport | Alaska | | | | | Juneau | 1935 | 1939 | Merged with Marine Airways to form Alaska Coastal Airlines. |
| Alaska Cargo | Alaska | | | | | | 2004 | 2004 | |
| Alaska Central Airways | Alaska | | | | | Ruby | 1974 | 1981 | Founded as Tanana Air Taxi. Acquired by Harold’s Air Service in 1981. |
| Alaska Coastal Airlines | Alaska | | | | | Juneau | 1939 | 1968 | Acquired by Alaska Airlines. |
| Alaska Flying Tours | Alaska | | | | | Fairbanks | 2001 | 2001 | Tour service operator |
| Alaska Interior Airlines | Alaska | | | | | Anchorage Merrill Field | 1936 | 1937 | Acquired by Star Air Lines |
| Alaska International Air | Alaska | | BF | AKA | INTERALAS | Anchorage | 1972 | 1984 | Founded as Interior Airways. Acquired by Great Northern Airlines in 1984 and renamed Markair |
| Alaska Island Air | Alaska | | | | | Petersburg Johnson | 1968 | 1988 | Founded as Lon's Flying Service |
| Alaska Island Airways | Alaska | | | | | Juneau | 1946 | 1954 | Merged with Alaska Coastal Airlines |
| Alaska Mountain Flying Service | Alaska | | | | | | 1992 | 2009 | |
| Alaska Southern Airways | Alaska | | | | | | 1932 | 1934 | |
| Alaska Star Airlines | Alaska | | | | | Anchorage | 1932 | 1944 | Founded as Star Air Lines. Renamed Alaska Airlines in 1944. |
| Alaska West Air | Alaska | | | | | | 1989 | 2009 | |
| Alaska-Washington Airways | Alaska | | | | | | 1929 | 1930 | Acquired by Seattle-Wenatchee-Yakima Airways |
| Alaskan Airways | Alaska | | | | | | 1930 | 1932 | Acquired by Pacific Alaska Airways |
| Alaskan Coastal Airways | Alaska | | | | | | 1986 | 1986 | |
| Albany Air | New York | | YU | | | Albany | 1979 | 1979 | |
| Albany Air Service | New York | | | | | Albany | 1962 | 1964 | |
| Alii Air Hawaii | Hawaii | | | | | | 1970 | 1975 | Renamed Brandt Air in 1975 |
| ALL | Colorado | | | | | Front Range | 1988 | 2006 | Cargo charter |
| All American Aviation | Pennsylvania | | | | | Pittisburgh | 1937 | 1939 | |
| All Hawaii Air | Hawaii | | | | | Honolulu | 1979 | 1979 | Cargo carrier |
| All Star Airlines | Massachusetts | | | ASR | ALL STAR | Woburn | 1985 | 1993 | Charter carrier |
| All-American Airways | Florida | | | | | Miami | 1948 | 1960 | Supplemental air carrier renamed Saturn Airways in 1960 |
| All West Freight | Alaska | | | | | Nikiski | 1996 | 2012 | Operated Fairchild C-123 Provider |
| All-America Airlines | California | | | | | Long Beach | 1994 | 1994 | |
| Allcair Air Transport | Texas | | | | | Laredo | 1993 | 1993 | Operated Douglas C-118 |
| Allegheny Air Cargo | Pennsylvania | | | | | Pittsburgh | 1947 | 1947 | Operated Douglas DC-3 |
| Allegheny Airlines | Pennsylvania | | AL | ALO | ALLEGHENY | Pittsburgh | 1959 | 1979 | Renamed to US Airways |
| Allegheny Commuter | Pennsylvania | | | | | DuBois | 1969 | | Renamed to Crown Airways |
| Allen Air Commuter | Kansas | | | | | Topeka | 1967 | 1975 | Founded as Allen Aviation. Acquired by Capitol Airlines |
| Alliance Airlines | Illinois | | | ALZ | ALLIANCE AIR | Chicago O'Hare | 1984 | 1988 | Acquired by Great Lakes Airlines |
| Allied Air Freight | Florida | | | | | Miami-Opa Locka | 1996 | 2001 | Operated Douglas C-47 |
| Aloha Airlines | Hawaii | | AQ | AAH | ALOHA | Honolulu | 1946 | 2008 | Founded as Trans-Pacific Airlines. Cargo operations still active under Aloha Air Cargo. |
| Aloha IslandAir | Hawaii | | | | | Honolulu | 1987 | 1992 | Founded as Princeville Airways. Acquired by Island Air |
| Aloha Pacific | Hawaii | | | | | Honolulu | 1984 | 1985 | |
| Alpha Air | California | | 7V | ALH | ALPHA AIR | Los Angeles | 1976 | 1995 | |
| Alpine Airbus | California | | | | | Los Angeles | 1973 | 1973 | |
| Alpine Aviation | Nevada | | | | | Nevada County Air Park | 2005 | 2005 | |
| Alpine Aviation Corporation | Illinois | | | | | Chicago Rockford | 1980 | 1981 | |
| Altair Airlines | Pennsylvania | | AK | AAR | ALTAIR | Philadelphia | 1967 | 1982 | |
| Altus Airlines | Oklahoma | | 2U | AXS | ALTUS | Altus/Quartz Mountain | 1985 | 1987 | |
| Alyeska Air Service | Alaska | | | ALY | ALYESKA | Anchorage | 1982 | 1989 | |
| Ambassadair | Indiana | | | | | Indianapolis | 1974 | 1981 | Operated Boeing 720, Boeing 727 |
| Ambassador Airlines | Nevada | | | | | Las Vegas McCarran | 1963 | 1968 | Subsidiary of American Trans Air. Operated Beech 18, Aero Commander 500 |
| Amelia Airways | Florida | | | | | Fort Lauderdale Executive | 1993 | 2000 | On-demand service Operated Piper Navajo Chieftain |
| America West Airlines | Arizona | | HP | AWE | CACTUS | Phoenix Sky Harbor | 1981 | 2007 | Commenced operations in 1983. Merged with US Airways, then merged with American Airlines |
| America West Express | Nevada | | RP | CHQ | AIR SHUTTLE CHATAUQUA | Las Vegas McCarran | 1985 | 2007 | |
| AmericAir | Oklahoma | | DE | AAR | PATRIOT | Washington Dulles | 1983 | 1985 | |
| American Air Taxi | Florida | | | | | Key West | 1960 | 1974 | Renamed Air Sunshine (1974). Operated Beech 99, Piper Aztec, de Havilland Heron |
| American Air Transport and Flight School | Florida | | | | | Miami | 1948 | 1952 | Irregular air carrier shut by the CAB in 1952 for flying scheduled service. |
| American Central Airlines | Iowa | | JR | AAR | | Dubuque | 1980 | 1984 | |
| American Export Airlines | New York | | | | | New York-LaGuardia | 1937 | 1945 | Renamed to American Overseas Airlines |
| American Flyers Airline | Oklahoma | | | | | Ardmore | 1949 | 1971 | Taken over by Universal Airlines |
| American International Airways | Florida | | | | | Key West | 1926 | 1927 | Seaplane service to Havana |
| American International Airways | New York | | | | | New York-LaGuardia | 1947 | 1949 | Operated Boeing 314, DC-4 |
| American International Airways | Pennsylvania | | CB | CKS | | Philadelphia | 1967 | 2000 | Merged with Kitty Hawk International and rebranded as Kalitta Air |
| American International Airways | New Jersey | | | | | Atlantic City | 1981 | 1984 | Established as Commercial Airlines in 1980. Operated MD-80, DC-9 |
| American Overseas Airlines | New York | | | | | New York-LaGuardia | 1937 | 1950 | Founded as American Export Airlines. Merged with Pan American Airways |
| American Overseas | | | | | | | 1980s | 1980s | |
| American Railway Express | District of Columbia | | | | | Washington, D.C. | 1918 | 1929 | Freight service Renamed Railway Express Agency Operated a Handley Page converted bomber |
| American Trans-Oceanic Company | New York | | | | | Port Washington | 1916 | 1928 | |
| AmericanConnection | Illinois | | AX | | | Chicago O'Hare | 2001 | 2014 | |
| AMI Jet Charter | California | | | | | San Francisco | 1998 | 2007 | |
| Amistad Airline | Texas | | | | | Del Rio | 1966 | 1980 | |
| Anchorage Air Transport | Alaska | | | | | Anchorage | 1927 | 1928 | |
| Anchorage Airways | Alaska | | | | | Anchorage | 1981 | 1982 | Established as Air Logistics |
| Angier Flying Service | North Carolina | | | | | Piedmont Triad | 1975 | 1975 | |
| Antelope Airlines | Wyoming | | | | | Gillette–Campbell | 1974 | 1975 | |
| Apache Airlines | Arizona | | | | | Phoenix Sky Harbor | 1957 | 1970 | |
| Apex Air Cargo | | | | APX | PARCEL EXPRESS | Honolulu | 1987 | 1989 | |
| Apollo Airways | California | | | SNC | SONIC | Santa Barbara | 1969 | 1982 | Renamed to Pacific Coast Airlines |
| Appalachian Airlines | Tennessee | | DI | | | Tri-Cities | 1977 | 1980 | |
| Arctic Circle Air | Alaska | | 5F | CIR | AIR ARCTIC | Fairbanks | 1973 | 2009 | Acquired by Era Alaska |
| Arctic Frontier Airways | Washington | | | | | Seattle–Tacoma | 1948 | 1948 | |
| Arctic Guide Air Taxi | Alaska | | | | | Barrow | 1974 | 1985 | Charter carrier |
| Arctic Pacific Airlines | Washington | | | | | Seattle-Tacoma | 1947 | 1970 | Charter carrier |
| Arctic Transportation Services | Alaska | | 7S | RCT | | Anchorage | 1950 | 2010 | Rebranded as Ryan Air Services |
| Argonaut Airways | Florida | | | | | Miami | 1946 | 1962 | Supplemental air carrier cargo line. Voluntarily gave up operating authority in 1962 |
| Argosy Air Lines | Florida | | VJ | ARY | GOSEY | Fort Lauderdale Executive | 1971 | 1978 | |
| Aries Air Cargo | California | | | | | Los Angeles | 1973 | 1973 | Cargo carrier |
| Arista International Airlines | New York | | RY | | | New York Kennedy | 1982 | 1984 | Established as Tourlite International Airlines in 1980. |
| Arizona Air | Arizona | | | AAE | ARIZONA | Scottsdale | 1992 | 1995 | Scenic flights and charter |
| Arizona Airways | Arizona | | | AAE | ARIZONA | Phoenix Sky Harbor | 1946 | 1950 | Merged with Summit Airways and Monarch Air Lines to form Frontier Airlines (1950–1986) |
| Arizona Airways (1993–1996) | Arizona | | VZ | AZY | ARIZAIR | Tucson | 1993 | 1996 | To Arizona Airways Express |
| Arizona Airways Express | Arizona | | | | | Tucson | 1995 | 1996 | Merged into Great Lakes Airlines |
| Arizona Express | Arizona | | K7 | TMP | TEMPE | Phoenix Sky Harbor | 2001 | 2005 | |
| Arizona Helicopters | Arizona | | | | | Chandler | 1970s | 1970s | Operated in Laos during the 1970s |
| Arizona Pacific Airlines | Arizona | | | AZP | ARIZONA PACIFIC | Flagstaff | 1981 | 1982 | Began as Omni Airlines |
| Arkansas Traveler Airline | Arkansas | | | HOG | HOG-AIR | | 1984 | 1984 | |
| Armstrong Air Service | Alaska | | | | | Dillingham | 1985 | 1989 | |
| Arnold Air Service | Alaska | | | | | | 1946 | 1946 | Operated Douglas DC-3 |
| Aroostook Airways | Maine | | | | | Presque Isle | 1969 | 1972 | |
| Arrow Air | Florida | | JW | APW | BIG A | Miami | 1947 | 2010 | |
| Arrowhead International Airlines | Minnesota | | | | | Duluth | 1929 | 1930 | Merged with Canadian-American Airlines Operated Lockheed Vega |
| ASA (Alaska Southcoast Airways) | Alaska | | | | | | 1974 | 1974 | |
| ASA International Airlines | Florida | | JI | JI | | | 1947 | 1965 | Trade name for Aerovias Sud Americana |
| ASAP (All Seasons Air Pacific) | California | | | | ALL | Long Beach | 1981 | 1983 | |
| Asheville Flying Service | North Carolina | | | | | Asheville | 1982 | 1983 | |
| Aspen Airways | Colorado | | AP | ASP | ASPEN AIR | Denver Stapleton | 1952 | 1990 | Merged into Air Wisconsin |
| Aspen Airways Air Taxi | Colorado | | | | | Aspen | 1953 | 1955 | Renamed Aspen Airways |
| Aspen Mountain Air | Colorado | | AD | | | Denver | 1996 | 1998 | See Lone Star Airlines |
| Associated Air Transport | Florida | | | | | Miami | 1949 | 1962 | Operated Sikorsky VS-44, DC-3, C-46, L-749 |
| Associated Airways | | | | | | Burbank | 1949 | 1951 | Previously Airplane Charter by Mercer. Irregular air carrier shut by CAB in 1951 for scheduled svc |- | Astar Air Cargo | Florida | ER | DHL | DAHL | Cincinnati/Northern Kentucky | 1969 | 2012 |
| Astec Air East | New York | | | AAE | AIR EAST | Canandaigua | 1974 | 1982 | |
| Astro Airways | Arkansas | | JW | AST | ASTRO-AIR | Pine Bluff | 1969 | 1995 | |
| ATA Airlines | Indiana | | TZ | AMT | AMTRAN | Chicago Midway | 1973 | 2008 | Founded as Ambassadair |
| ATA Connection | Illinois | | | | | Chicago Midway | 1983 | 2008 | |
| Atlanta Express | Georgia | | FX | | AYTEX | Atlanta | 1982 | 1987 | Merged into Sunbird Airlines |
| Atlanta Helicopter Airways | Georgia | | | | CITRUS | Atlanta | 1960 | n/a | |
| Atlanta Skylarks | Georgia | | | SLK | SKYLARK | Atlanta | 1966 | 1986 | Renamed Independent Air in 1986 |
| Atlantic & Pacific Airlines | Texas | | | | | | 1947 | 1947 | Operated Douglas DC-3 |
| Atlantic Air | Massachusetts | | | GAA | ATLANTIC AIR | Boston | 1981 | 1984 | Renamed to BEX Business Express |
| Atlantic and Gulf Coast Airlines | South Carolina | | | | | Savannah-Hilton Head | 1937 | 1937 | |
| Atlantic Central Airlines | Maine | | | | | Bangor | 1975 | 1976 | Operated Beech 18 |
| Atlantic City Airlines | New Jersey | | | | | Atlantic City | 1965 | 1977 | Renamed Southern Jersey Airways Operated Twin Otters |
| Atlantic Coast Airlines | Virginia | | | | | Washington Dulles | 1989 | 2006 | Merged into Independence Air |
| Atlantic Coast Jet | | | | | | | 1989 | 2003 | Operated Dornier 328JET |
| Atlantic Gulf Airlines | Florida | | ZY | AGF | ATLANTIC GULF | Tampa | 1983 | 1986 | |
| Atlantic North Airlines | New Hampshire | | 8M | SDD | SKY DANCE | Laconia | 1993 | 1993 | Merged into Ocean Air Tradeways |
| Atlantic Seaboard Airlines | New Jersey | | | | | Bader Field | 1960 | 1961 | |
| Atlantic Southeast Airlines | Georgia | | EV | ASQ | ACEY | Detroit | 1979 | 2011 | Merged into ExpressJet |
| Atlantis Airlines | North Carolina | | SG | AAO | ATLANTIS AIR | Charlotte | 1979 | 1991 | Branded as Eastern Atlantis Express |
| ATO America Trans-Oceanic Company | Florida New York | | | | | Miami Long Island City | 1920 | 1921 | Acquired by Curtiss-Metropolitan Airplane Company |
| Atorie Air | Texas | | | PAV | ATORIE-AIR | El Paso | 1983 | 1986 | Founded as Pronto Aviation Services Operated Douglas DC-3 |
| ATX Air Services | Texas | | | | | Fort Worth Alliance | 2013 | 2016 | Rebranded to Hillwood Airways |
| Austin Express | Texas | | 7V | TXX | COWBOY | Austin-Bergstrom | 1997 | 2000 | |
| Austral Aviation | Wisconsin | | AL | SYX | | Milwaukee Mitchell | 1994 | 2008 | |
| Av Atlantic | Florida | | G6 | KYC | DOLPHIN | Fort Lauderdale–Hollywood | 1991 | 1996 | |
| AVAir | North Carolina | | | | | Raleigh Durham | 1986 | 1989 | Former American Eagle operator |
| Avalon Air Transport | California | | | | | Long Beach | 1953 | 1963 | |
| Avery Aviation | Wyoming | | | | | Greybull | 1961 | 1969 | Operated Consolidated Privateer, Cessna 180 |
| Aviation Enterprises | Texas | | | | | | 1940 | 1947 | Renamed to Trans-Texas Airways |
| Aviation Services Inc. | Kansas | | | | | Wichita | 1967 | 1969 | Founded by Gary M. Adamson. Renamed to Air Midwest |
| Aviex Jet | Texas | | | | | Houston | 1979 | 1999 | Operated Super King Air 200, Learjet 25, Aero Commander 1121 Jet Commander |
| Avolar | Nevada | | | VLX | AVOLAR | Las Vegas McCarran | 2001 | 2002 | |
| Aztec Air | Florida | | | | | Panama City | 1967 | 1996 | |
| Aztec Air | California | | | | | Long Beach | 1989 | 1989 | Charter carrier |
| Aztec Airlines | Texas | | | | | El Paso | 1966 | 1967 | |
| B ||||||||||
| B & C Aviation | Tennessee | | | | | Nashville | 1973 | 1999 | Operated Learjet 24, Learjet 25 |
| B Airways | Florida | | | | | Miami | 1989 | 1990 | Operated Douglas DC-3 |
| B Airways Air Cargo | Florida | | | | | Miami | 1997 | 1999 | |
| B.A.S Airlines | Ohio | | | | | Youngstown–Warren | 1981 | 1988 | Founded as Skyline Motors Aviation |
| Bahamas Express | Florida | | | | | Miami | 1987 | 1988 | Established as Pacific Inter Air. Renamed Majestic Air |
| Baja Cortez Airlines | California | | XT | BCA | | Los Angeles | 1977 | 1983 | Operated BN Islander, Riley Turbo Skyliner |
| Bakersfield Aviation Services | California | | | | | Meadows Field | 1973 | 1975 | Operated Beech E18S, Beech Bonanza |
| Ball Brothers | Alaska | | | | | Anchorage | 1977 | 1980 | Fresh fish carrier |
| Baltia Air Lines | New York | | | | | New York Kennedy | 1989 | 2018 | Renamed to USGlobal Airways |
| Baltimore Air Charter | Maryland | | | | | Baltimore–Washington | 2004 | 2006 | |
| Baltimore Airways | Maryland | | | | | Logan Field | 1929 | 1930 | |
| Baltimore Airways Company | Maryland | | | | | Park Heights, Baltimore | 1929 | 1929 | |
| Baltimore Helicopter Services | Maryland | | | | | Baltimore–Washington | 2004 | 2015 | Renamed GrandView Aviation |
| Bar Harbor Airlines | Maine | | QO | AJC | BAR HARBOR | Bangor | 1950 | 1971 | Merged into Continental Express |
| Barnes and Gorst Air Mail | Washington | | | | | Seattle Lake Union Seaplane Base | 1927 | 1927 | |
| Barnhill & McGee Airways | Alaska | | | | | Anchorage | 1931 | 1932 | Forerunner of McGee Airways |
| Barr Air Transport | Alaska | | | | | | 1935 | 1938 | Founded by Frank Barr |
| BAX Global | Florida | | 8W | | | Miami | 1997 | 2011 | Founded as Burlington Northern Airfreight then Burlington Air Express |
| Bay Valley Air Service | California | | | | | San Francisco | 1947 | | |
| Bee Line | Connecticut | | | | | | 1923 | 1925 | Renamed to Colonial Air Transport |
| Beeson Aviation | Kansas | | | | | Concordia | 1965 | 1968 | Absorbed by Trans-Mo Airlines |
| Bellair | Alaska | | 7G | | | Anchorage | 1980 | 2004 | Operated Volpar Turboliner |
| Bellingham-Seattle Airways | Washington | | | | | Bellingham | 1964 | 1969 | Merged into Puget Sound Airlines |
| Bennett-Rodebaugh Company | Alaska | | | | | | 1927 | 1927 | |
| Best Airlines | Kentucky | | IW | BST | BESTWAY | Cincinnati/Northern Kentucky | 1982 | 1986 | |
| Biegert Aviation | Arizona | | | | | Chandler | 1984 | 1993 | Cargo carrier Operated Douglas C-54 |
| Big Sky Airlines | Montana | | GQ | BSY | BIG SKY | Billings Logan | 1978 | 2008 | |
| Bimini Island Air | Florida | | | BMY | BIMINI | Fort Lauderdale–Hollywood | 1993 | 2011 | AOC removed by the FAA in 2011 |
| BizAir Shuttle | Ohio | | UE | | | DuPage | 2015 | 2015 | Established as BizCharters Operated Dornier 328, ERJ-135 |
| Blackhawk Airways | Wisconsin | | BB | BAK | BLACKHAWK | Southern Wisconsin | 1970 | 1996 | Operated Beech E18S |
| Blatz Airlines | California | | | | | Burbank | 1947 | 1962 | Operated DC-3, DC-4 |
| Blatz Airlines | Nevada | | | | | | 1963 | 1963 | Renamed Nevada Airlines. Formed Hawthorne-Nevada Airlines in 1964 |
| Blue Dog | Washington | | | | | Omak | 1968 | 1971 | Commuter services Operated Aero Commander 560, Cessna 182 |
| Blue Line Air Express | Wisconsin | | 4U | | | Medford | 1982 | 1982 | |
| Blue Moon Aviation | Minnesota | | | | | Minneapolis–Saint Paul | 2003 | 2005 | |
| Bluebell Aviation | | | | | | | 1969 | 1973 | Renamed to Wrangler Aviation |
| Bluegrass Airlines | Kentucky | | | | | Bowling Green | 1944 | 1946 | |
| Bo-S-Aire | | | | BAA | BOWMAN AIR | | 1979 | 1989 | |
| Bob Harris Flying Service | Alaska | | | | | Bethel | 1956 | 1975 | Renamed Yute Air Alaska |
| Boeing Air Transport | Washington | | | | | Boeing Field | 1927 | 1930 | To United Airlines |
| Boise Aviation | Idaho | | | | | Boise | 1967 | 1971 | Third-level services |
| Bonanza Air Lines | Nevada | | BL | | BONANZA | North Las Vegas | 1945 | 1968 | Merged with Pacific Air Lines and West Coast Airlines to form Air West which was then renamed Hughes Airwest |
| Bonanza Airlines | Arizona | | | BON | BONAIR | Phoenix Sky Harbor | 1978 | 1978 | Established as Mountain West Airlines |
| Borrego Springs Airline | California | | | | | Borrego Valley | 1968 | 1968 | Renamed Sun Aire Lines |
| Boone County Airlines | Kentucky | | | | | Cincinnati/Northern Kentucky | 1946 | 1950 | |
| Boston Airport Corporation | Massachusetts | | | | | East Boston | 1925 | 1926 | Operated Travel Air |
| Boston Maine-Central Vermont Airways | Massachusetts | | | | | Boston | 1933 | 1940 | Formed by the merger of Boston Maine Airways and Central Vermont Airways |
| Boston-Maine Airways | Massachusetts | | | | | Boston | 1931 | 1933 | |
| Boston-Maine Airways | New Hampshire | | E9 | CXS | CLIPPER CONNECTION | Hanscom Field | 1999 | 2008 | |
| Bowen Air Lines | Texas | | | | | Dallas/Fort Worth | 1930 | 1935 | Acquired by Braniff Airways |
| Braniff International Airways | Texas | | BN | BNF | BRANIFF | Dallas/Fort Worth | 1930 | 1982 | Went bankrupt, some assets sold to Braniff Inc. |
| Braniff (1983–1990) | Texas | | BN | BNF | BRANIFF | Dallas/Fort Worth | 1983 | 1990 | Officially Braniff Inc. aka Braniff II; went bankrupt, assets sold to Braniff International Airlines, Inc. |
| Braniff (1991–1992) | Texas | | BE | | | Dallas/Fort Worth | 1991 | 1992 | Officially Braniff International Airlines, Inc. aka Braniff III; went bankrupt |
| Branson Airlines | Florida | | E5 | BRN | BRANSON | Fort Lauderdale Executive | 1992 | 1994 | Founded as Dash Airlines renamed Eclipse Airlines |
| Bremerton Air Taxi | Washington | | | | | Bremerton | 1964 | 1969 | |
| Britt Airways | Indiana | | RU | BTA | BRIT-AIR | Terre Haute | 1956 | 1985 | Founded as Vercoa Air Service. Merged into ExpressJet |
| Bristol Bay Air Service | Alaska | | | | | Bethel | 1930 | 1943 | Acquired by Ray Petersen Flying Service |
| Brockway Air | Vermont | | SS | CVA | BROCKWAY | Burlington | 1984 | 1989 | Merged into Metro Airlines |
| Brooks Air Transport | Alaska | | | | | Fairbanks | 1986 | 1986 | Renamed to Brools Fuel |
| Brooks Fuel | Alaska | | | | | Fairbanks | 1986 | 2008 | Founded as Brools Air Transport |
| Brower Airlines | Iowa | | UD | | | Fort Madison | 1968 | 1980 | Founded as Brower Airways |
| Buckeye Air Service | Ohio | | | | | Cleveland Hopkins | 1967 | 1971 | |
| Budyer Air | Wyoming | | | | | Evanston | 1981 | 1982 | |
| Buffalo Airways | Texas | | BV | BVA | | Waco | 1982 | 1996 | Operated Boeing 707, Canadair CL-44, Douglas DC-8 |
| Buker Airlines | Vermont | | | | | Hartness | 1966 | 1968 | Renamed to Trans East Airlines |
| Burdett Air Lines | California | | | | | Los Angeles | 1919 | 1927 | Jack Frye merged with Aero Corporation and Standard Air Lines |
| Burlington Air Express | California | | 8W | | | Miami | 1986 | 1997 | Merged into BAX Global |
| Burlington Airways | | | | BUR | BURLINGTON | | 1979 | 1982 | |
| Burlington Northern Airfreight | Florida | | | | | | 1972 | 1985 | Renamed to Burlington Air Express |
| Business Express Airlines | Massachusetts | | HQ | GAA | BIZEX | Boston | 1982 | 2000 | Merged into American Eagle Airlines |
| Byerly Airlines | Illinois | | | | | Jacksonville | 1955 | 1961 | |
| C ||||||||||
| C & M Airlines | California | | | REM | REM | Inyokern | 1979 | 1985 | Renamed to Indian Wells Airlines |
| C & R Connair | Connecticut | | | | | | 1967 | 1971 | Scheduled commuter services |
| C-Air | California | | | | | Los Angeles | 1964 | 1969 | |
| Cable Commuter Airlines | California | | | | | Cable | 1967 | 1969 | Established as Cable Air Taxi. Acquired by Aero Commuter |
| Cal Aero Airways | California | | | | | Van Nuys | 1969 | 1970 | |
| Cal Jet Elite Air | California | | | | | McClellan–Palomar | 2015 | 2018 | |
| Cal Sierra Airlines | California | | | | | San Diego | 1980 | 1981 | |
| Calasia Air Transport | California | | | | | Oakland | 1947 | 1950 | Changed name to Overseas National Airways in 1950 |
| California Air Charter | California | | | | | Lockheed Air Terminal | 1946 | 1959 | Originally Kesterson, founded in Knoxville, TN. |
| California Air Charter | California | | | CAC | CALAIR | Hollywood Burbank | 1968 | 1971 | Renamed to Ameriflight |
| California Air Commuter | California | | | CLM | CALCOM | Oakland | 1975 | 1979 | Owned by Martin Aviation |
| California Air Freight | California | | | | | | 1959 | 1959 | |
| California Air Shuttle | California | | | | | Oxnard | 1990 | 1990 | Operated Swearingen Metro |
| California Airways | California | | | | | Santa Monica | 1979 | 1986 | |
| California Central Airlines | California | | | | | Hollywood Burbank | 1949 | 1955 | California intrastate carrier, slightly preceding Pacific Southwest Airlines. Assets bought out of bankruptcy by Southwest Airways and Allegheny Airlines |
| California Eastern Airways | California | | | | | Oakland | 1946 | 1960 | Part 45 carrier that became a supplemental in 1959, only to transfer its certificate to President Airlines in 1960. |
| California Hawaiian Airlines | California | | | | | | 1952 | 1962 | A dba of Airline Transport Carriers |
| California Pacific Airlines | California | | | | | Burbank | 1950 | 1950 | Short-lived California intrastate airline. |
| California Pacific (CalPac) | California | | | | | Los Angeles | 1993 | 2005 | To Mesa Airlines |
| California Pacific Airlines | California | | 4A | DYN | AERODYNAMICS | McClellan–Palomar | 2018 | 2019 | |
| California Seaboard Airlines | Arizona | | | SSB | CAL SEABOARD | Laughlin/Bullhead | 1983 | 1986 | |
| California Time Airlines | California | | | | | Hollywood Burbank | 1963 | 1963 | |
| Cal-State Airlines | California | | | | | Los Angeles | 1968 | 1970 | |
| Cam Air International | | | OX | FLM | BOXHAULER | | 1983 | 1986 | Established as Fleming International Airways. Renamed to Spirit of America Airlines |
| Canadian Colonial Airways | New York | | | | | New York Flushing | 1928 | 1942 | Operated flight to Montreal. Renamed to Colonial Airlines |
| Canadian-American Airlines | Minnesota | | | | | Minneapolis | 1929 | 1930 | Merged with Arrowhead International Airlines Operated Lockheed Vega, Travel Air 6000 |
| Cape & Islands Air Freight | Massachusetts | | | | | Nantucket | ? | 2015 | Division of Island Airlines |
| Cape & Islands Airline | Massachusetts | | | | | Hyannis Barnstable | 1951 | 1970 | To Air New England Operated Beech 18, Twin Otter, Piper Navajo, Piper Aztec |
| Cape Smythe Air | Alaska | | 6C | CMY | CAPE SMYTHE AIR | Barrow | 1975 | 2005 | To Frontier Flying Service |
| Capital Airlines | Washington, D.C. | | CA | CAP | CAPITOL | Washington National | 1948 | 1961 | Merged into United Airlines |
| Capital Cargo International Airlines | Florida | | PT | CCI | CAPPY | Miami | 1996 | 2013 | Merged into ATI Air Transport International |
| Capitol Airlines | Kansas | | | | | Manhattan | 1965 | 1989 | Acquired by Allen Aviation. Operated as Braniff Express |
| Capitol Airways | Tennessee | | CL | CL | CAPITOL | Smyrna, Tennessee | 1946 | 1984 | Supplemental air carrier |
| Cardinal Airlines | Virginia | | NN | CDA | | Lynchburg | 1968 | 1976 | Renamed to Air Virginia, Operated BN Islander, Beech 99 |
| Cargo 360 | Washington | | GG | GGC | LONGHAUL | Seattle–Tacoma | 2005 | 2008 | To Southern Air |
| Caribair | Puerto Rico | | | | | San Juan | 1939 | 1973 | Merged into Eastern Airlines |
| Caribbean American Lines | | | | | | | | 1956 | Irregular air carrier shut by CAB in 1956 for flying scheduled service |
| Caribbean Express | Florida | | | | | Miami | 1983 | 1988 | Operated Embraer Bandeirante, Cessna 402B |
| Caribbean Sun | Florida | | | | | Miami | 2002 | 2007 | To World Atlantic Airlines |
| Carnival Air Lines | Florida | | KW | CAA | CARNIVAL AIR | Fort Lauderdale–Hollywood | 1988 | 1998 | Merged into Pan Am (1996), to Boston-Maine Airways |
| Cascade Airways | Washington | | CZ | CCD | CASCADE | Seattle-Tacoma | 1969 | 1986 | |
| Casino Express Airlines | Nevada | | XP | CXP | CASINO EXPRESS | Las Vegas McCarran | 1987 | 2005 | Rebranded as Xtra Airways |
| Catalina Air Lines | California | | | CAI | CATALINA | Long Beach | 1963 | 1967 | Avalon Air Transport (1953), then Catalina Air Lines (1963), acquired by Golden West Airlines |
| Catalina Air Transport | California | | | | | Santa Catalina Island | 1931 | 1942 | Founded as Wilmington-Catalina Airline in 1931. Renamed to Catalina Air Transport in 1941. Contracted with United Air Lines to operate to Catalina 1946-1954. |
| Catalina Channel Airlines | California | | | | | Pebble Beach | 1959 | 1966 | Founded by Bob Hanley. Used seaplane |
| Catlin Aviation | Oklahoma | | | CLN | CATLIN | Durant Eaker Field | 1969 | 1969 | Commuter services |
| Catskill Airways | New York | | KF | CSK | CATSKILL | Utica | 1966 | 1989 | Merged into Mohawk Airlines |
| CCAir | North Carolina | | ED | CDL | CAROLINA | Charlotte Douglas | 1987 | 2002 | |
| Centennial Airlines | Wyoming | | BE | CNL | WYO-AIR | Laramie | 1981 | 1987 | Merged into Mesa Airlines |
| Cen-Tex Airlines | Texas | | | CTX | CEN-TEX | | 1981 | 1983 | Commuter services |
| Central Airlines (1934) | Virginia | | | | | Washington National | 1934 | 1936 | Merged into Pennsylvania Airlines. Operated Stinson Model A |
| Central Airlines | Texas | | | | | Dallas Love Field | 1949 | 1967 | Merged into Frontier Airlines (1950–1986) |
| Central American Airways | Kentucky | | | | | Louisville | 1946 1963 | 1948 1973 | Irregular air carrier in 1940s. Uncertificated carrier from 1963. Became Central American International |
| Central American International | Kentucky | | | | | Louisville | 1973 | 1982 | Uncertificated carrier, follow on from Central American Airways. Became Trans International Airlines (1985–1989) |
| Central Iowa Airlines | Iowa | | | | | Davenport | 1973 | 1973 | Operated DC-3 |
| Central State Airlines | Ohio | | | | | Cleveland Shea Field | 1989 | 1990 | Operated BAe Jetstream |
| Centurion Air Cargo | Florida | | WE | CWC | CHALLENGE CARGO | Miami | 1985 | 2018 | Formerly known as Challenge Air Cargo |
| Century 2000 | | | | | | | 1971 | 1973 | |
| Century Airlines | Michigan | | | | | Oakland County | 1973 | 1996 | Established as S.S. Airways |
| Century Airlines | California | | | | | Arcata–Eureka | 1977 | 1981 | Established as Six Rivers Air Service |
| Century Pacific Air Lines | California | | | | | Los Angeles | 1931 | 1932 | To American Airways |
| CF Air Freight | | | | | | | 1986 | 1989 | Established as Consolidated Freightways. Merged into Emery Worldwide |
| CHA California Hawaiian | | | | | | | 1946 | 1962 | Charter airline |
| Chalk’s Flying Service | Florida | | | | | Miami | 1919 | 1936 | Renamed to Chalk's International Airlines Operated Stinson Voyager with floats |
| Chalk's International Airlines | Florida | | BK | CHK | CHALKS | Miami Seaplane Base | 1996 | 1996 | Established as Red Arrow Flying Service in 1917 Operated DHC-7 Dash 7, Grumman Albatross, Grumman Mallard |
| Chalk’s Ocean Airways | Florida | | OP | CHK | | Miami | 1999 | 2005 | Renamed to Chalk's International Airlines Operated Beech 1900D, Grumman G-73 Mallard, Saab 340A |
| Challenge Air Cargo | Florida | | WE | CWC | CHALLENGE CARGO | Miami | 1985 | 2001 | Charter airline |
| Challenge Air International | Florida | | VV | OFF | CHALLENGE AIR | Miami | 1984 | 1987 | Former Challenge International Airlines |
| Challenger Airlines (1946) | Utah | | | | | Salt Lake City | 1946 | 1946 | Utah intrastate airline, same parent company as Challenger Airlines |
| Challenger Airlines | Wyoming | | | | | Laramie, Wyoming, Salt Lake City, Denver | 1947 | 1950 | Merged with Monarch Air Lines and Arizona Airways to form Frontier Airlines (1950–1986) |
| Champion Air | Minnesota | | MG | CCP | CHAMPION AIR | Minneapolis–Saint Paul | 1995 | 2008 | Formed from MGM Grand Air |
| Channel Air Lift | Hawaii | | | | | Honolulu | 1967 | 1969 | Went bankrupt |
| Chapman Air | | | | EXR | EXPRESS COURIER | | 1978 | 1985 | Renamed to Flight Express, Inc. |
| Chapparal Airlines | Texas | | FC | CPL | CHAPPARAL | Abilene | 1975 | 1990 | Merged into Metro Airlines |
| Charter Air Transport | Ohio | | VC | | | Cleveland Hopkins | 1997 | 2015 | Renamed to Via Airlines |
| Charter Airlines | Florida | | | | | Gainesville | 1977 | 1979 | Established as Charterair Commuter Airline. Merged into Mackey International Airlines. Operated Convair 580 |
| Charter One Airlines | Michigan | | | | | Detroit | 1980 | 1992 | Renamed to Spirit Airlines |
| Charterair Commuter Airlines | Florida | | HO | | CITRUS | Gainesville | 1977 | 1979 | Renamed to Charter Air Center |
| Chatham Airlines | | | | | | | 1964 | 1970 | Established as Lemco Flying Services |
| Chautauqua Airlines | Indiana | | RP | CHQ | CHAUTAUQUA | Chicago O'Hare | 1973 | 2014 | To Shuttle America |
| Cherokee Airlines | | | | | | | | | |
| Cherokee Airtaxi | Florida | | | | CITRUS | Athens Ben Epps | 1968 | 1971 | |
| Chesapeake Airways | Maryland | | | | | Salisbury–Ocean City | 1946 | 1965 | Merged into Metro Airlines |
| Chicago Air | Illinois | | CH | CHGO | WILDONION | Chicago Midway | 1985 | 1986 | |
| Chicago Airways | Illinois | | | | | Chicago O'Hare | 1959 | 1961 | |
| Chicago and Southern Air Lines | California | | CS | CSA | | Peoria Downing | 1933 | 1953 | As Pacific Seaboard Air Lines, rebranded Chicago and Southern Air Lines (1935), merged with Delta Air Lines |
| Chicago Express Airlines | Illinois | | C8 | WDY | WINDY CITY | Chicago Midway | 1993 | 2005 | |
| Chicago Helicopter Airways | Illinois | | | | | Chicago O'Hare | 1954 | 1965 | Established as Helicopter Air Service |
| Chippewa Air Commuter | Michigan | | | CPW | CHIPPEWA-AIR | Manistee | 1977 | 1978 | |
| Christiansen Air Service | Alaska | | | | | Anchorage | 1956 | 1956 | Acquired by Cordova Airlines |
| Christler Flying Services | New York | | | CHR | CHRISTLER | | 1970 | 1979 | Aerial spraying |
| Christler-Avery Aviation | Wyoming | | | | | Greybull | 1951 | 1961 | Founded by Mel Christler and Morris Avery. Operated B-18 Bolo, B-25 Mitchell, Northrop Delta |
| Christman Air System | Pennsylvania | | SX | CAS | CHRISTMAN | Washington County | 1977 | 1991 | |
| Cimarron Aire | Oklahoma | | | CMN | | McAlester | 2004 | 2006 | |
| CitationAir | Connecticut | | | FIV | FIVE STAR | White Plains | 1998 | 2014 | |
| CityLink Airlines | | | | HSR | HOOSIER | | 2001 | 2002 | |
| Clearwater Flying Service | Idaho | | | CFS | | Orofino | 1977 | 1977 | Renamed to Empire Airlines |
| Cleveland-Detroit Air Line | Ohio | | | | | Cleveland Hopkins | 1927 | 1928 | |
| Clifford Ball Airline | Pennsylvania | | | | | Bettis Field | 1927 | 1930 | Acquired by Pennsylvania Airlines |
| Clinton Aero | New York | | SS | CVA | CLINCO | Plattsburgh | 1971 | 1984 | Merged with Air North to form Brockway Air |
| Club International | Washington | | | | | Boeing Field | 1971 | 1975 | Air travel club that preceded Aeroamerica |
| Coastal Air | Georgia | | | | | Atlanta | 1975 | 1976 | Renamed to Southeastern Commuter Airlines |
| Coastal Air Freight | | | | | | | | | Operated Fokker Super Universal |
| Coastal Air Lines | California | | | | | San Francisco | 1947 | 1962 | Began as Coastal Cargo. Its certificate was taken over by Zantop Air Transport |
| Coastal Airlines | Florida | | | | | St. Petersburg–Clearwater | 1968 | 1969 | |
| Coastal Airlines | Rhode Island | | | | | Warwick | 1983 | 1989 | Began as National Air |
| Coastal Airways | Washington | | PN | SQV | COASTAL AIR | Sequim Valley | 1982 | 1992 | Operated commuter service |
| Coastal Plains Commuter | South Carolina | | | | | Hilton Head | 1978 | 1979 | |
| Cochise Airlines | Arizona | | DP | | | Tucson | 1971 | 1982 | |
| Coker Airfreight | Texas | | | | | Dallas Fort Worth | 1969 | 1984 | Renamed to Skyfreighters. Operated DC-3 |
| Coleman Air Transport | Illinois | | | | | Chicago Rockford | 1977 | 1980 | Founded by Philip Coleman. |
| Colgan Air | Tennessee | | 9L | CJC | COLGAN | Memphis | 1991 | 2012 | Established an FBO (1965), flights began 1970, sold to Presidential Airways (1986), restarted as National Capital (1991), merged to Pinnacle Airlines |
| Colonial Air Transport | New York | | | | | New York-LaGuardia | 1926 | 1930 | To American Airlines |
| Colonial Airlines | New Jersey | | | | | New York-LaGuardia | 1928 | 1956 | Established as Canadian Colonial Airways, merged into Eastern Air Lines |
| Colonial Western Airways | New York | | | | | Albany | 1927 | 1929 | |
| Colorado Airlines | Colorado | | | | | Crested Butte | 1977 | 1979 | Known as Crested Butte Air Service |
| Columbia Air | Virginia | | | | | Washington National | 1981 | 1982 | |
| Columbia Pacific Airlines | Washington | | 7C | | | Seattle-Tacoma | 1977 | 2002 | Established as Execuair in 1971 |
| Columbus Airlines | Florida | | | | | Fort Lauderdale–Hollywood | 1995 | 1996 | Established as Liberty Airways |
| Colvin Air Charter | Georgia | | | | | Athens Ben Epps | 1999 | 2004 | |
| Comair | Kentucky | | OH | COM | COMAIR | Cincinnati/Northern Kentucky Orlando | 1977 | 2012 | Shut down by parent company Delta Air Lines |
| Comair Jet Express | Kentucky | | | | | Cincinnati/Northern Kentucky | 2000 | 2001 | Delta Air Lines subsidiary |
| Comanche Air | Washington | | | | | Ephrata | 2000 | 2001 | |
| Combs Airways | Colorado | | | | | Denver | 1957 | 1984 | Began as Combs Freightair |
| Command Air | North Dakota | | | | | | 1966 | 1969 | Merged into Red Baron Airlines |
| Command Airways | New York | | DD | CMD | COMMAND | Hudson Valley | 1965 | 1988 | Renamed to Flagship Airlines |
| Commutair | Texas | | | | | Houston Bush | 1978 | 1980 | |
| Commutaire International Airways | Florida | | | | | Miami | 1976 | 1977 | |
| Commute Air | Washington | | | | | Spokane | 1967 | 1968 | |
| Commuter Airlines | New York | | | | | Greater Binghamton | 1964 | 1984 | Established as Broome County Aviation |
| Commuter Airlines | Iowa | | | | | Sioux City | 1965 | 1971 | |
| Compass Airlines | Minnesota | | CP | CPZ | COMPASS | Minneapolis–Saint Paul | 2006 | 2020 | Shutdown due to travel disruptions caused by the COVID-19 pandemic |
| Concord Airlines | New Jersey | | | | | | 1970 | 1971 | Third-level services |
| Concord International Airlines | Florida | | | | | | 1980 | 1982 | Established as Jet Freight Cargo |
| Connectair | California | | | CCR | CONNECTAIR | Santa Barbara | 1980 | 1984 | |
| Conner Air Lines | Florida | | CS | | | Miami | 1948 | 1992 | Operated C-46, DC-3, DC-6, DC-8 |
| Connie Kalitta Services | Michigan | | | CKS | CONNIE | Cincinnati/Northern Kentucky | 1967 | 1984 | To American International Airways |
| Conquest Airlines | Texas | | 5C | CAC | CONQUEST | San Antonio | 1986 | 1997 | Acquired by Air L.A. |
| Conquest Sun Airlines | Georgia | | | | | Atlanta | 1993 | 1994 | Renamed to AirTran Airways |
| Continental Air Services, Inc | Nevada | | | | | Los Angeles | 1965 | | A subsidiary of Continental Airlines |
| Continental Airlines | Texas | | CO | COA | CONTINENTAL | Houston Bush | 1937 | 2012 | Merged into United Airlines |
| Continental Charters | Florida | | | | | Miami | 1945 | 1954 | Irregular air carrier bankrupt 1954, then bought for $20 after which CAB refused to allow it to operate |
| Continental Connection | | | | | | Cleveland Hopkins | | 2012 | Included Cape Air, Colgan Air, CommutAir and Silver Airways, merged with United Express |
| Continental Express | Texas | | CO | | Continental Express | Cleveland Hopkins | 1986 | 2012 | Operations absorbed by United Express on merger of parent companies |
| Continental Lite | | | | | | Cleveland Hopkins | 1993 | 1995 | Airline within an airline, brand of Continental Airlines |
| Continental Micronesia | Guam | | CS | CMI | AIR MIKE | Guam | 1968 | 2010 | Founded as Air Micronesia. Subsidiary of Continental Airlines until 2010; subsidiary of UCH until 2017 when it was officially merged into United Airlines |
| Continental Sky-Van | Texas | | | | | Dallas | 1946 | 1946 | irregular air carrier |
| Continental West | Texas | | CO | | | Los Angeles | 1985 | 1986 | New division of Texas Air Corporation |
| Contract Air Cargo | Michigan | | | TSU | TRANSAUTO | Oakland County | 1983 | 2005 | Rebranded as Gulf and Caribbean Cargo |
| Cook Inlet Aviation | Alaska | | | CKA | COOK-AIR | Homer | 1989 | | Renamed to Inlet Airlines |
| Copper State Airlines | Arizona | | | ROD | ROADRUNNER | Douglas | 1980 | 1982 | |
| Coral Air | United States Virgin Islands | | VY | VYK | | Saint Croix | 1980 | 1985 | Acquired the operation of Eastern Caribbean Airlines. Operated GAF Nomad, Embraer Bandeirante, Twin Otter |
| Cordova Airlines | Alaska | | | | | Cordova | 1934 | 1968 | Acquired by Alaska Airlines |
| Coronado Flyers | California | | | | | | 1975 | 1981 | Operated DC-3 |
| Corporate Air Fleet | Tennessee | | | CTX | CATBIRD | Nashville | 1978 | 1998 | |
| Corporate Airlines | Tennessee | | 3C | CEA | CORP X | Smyrna | 1996 | 2007 | Renamed as Corporate Airlines in 1997. Changed name to RegionsAir in 2004. |
| Corporate Express Airlines | Tennessee | | | | | Nashville | 1996 | 1998 | Renamed to Corporate Airlines |
| Cortland Air Company | Ohio | | | | | Youngstown–Warren | 2003 | 2009 | |
| Cosmopolitan Airlines | New York | | | | | Republic | 1978 | 1980 | |
| Cromwell Air Lines | Texas | | | | | Dallas Love Field | 1929 | 1931 | Operated Stinson Aircraft Company |
| Cross Sound Commuter | Washington | | | | | Seattle–Tacoma | 1970 | 1974 | |
| Crown Airways | Pennsylvania | | | CRO | CROWN AIRWAYS | DuBois | 1969 | 1994 | Began as Allegheny Commuter, to Mesa Airlines |
| Cryderman Air Service | Michigan | | | | | Oakland County | 1977 | 1978 | |
| Crystal Air Aviation | California | | | | | Van Nuys | 2007 | 2012 | Renamed to Fuga Air Charter |
| Crystal Shamrock Airlines | Minnesota | | | CYT | CRYSTAL AIR | Minneapolis Crystal | 1972 | 1991 | |
| Cumberland Airlines | Maryland | | NQ | | | Greater Cumberland | 1969 | 1988 | Established as Nicholson Air Services |
| Curtiss Flying Service | Massachusetts | | | | | Boston | 1929 | 1932 | Operated amphibious aircraft |
| Curtiss Metropolitan Airplane Company | Florida | | | | | Miami-Opa Locka | 1921 | 1924 | Established as America Trans-Oceanic Company. Newspaper deliveries |
| Custom Air Transport | Florida | | 5R | CTT | CATT | Fort Lauderdale–Hollywood | 1985 | 2008 | |
| Cutter Flying Service | New Mexico | | | | | Albuquerque | 1969 | 1969 | |