# List of The Late Late Show with Craig Ferguson episodes

The Late Late Show with Craig Ferguson is an American late-night talk show that aired weeknights at 12:37 am (Los Angeles time) on CBS in the United States from January 3, 2005, to December 19, 2014. The hour-long show was hosted by Scottish American comedian, actor and author Craig Ferguson, with his animatronic robot skeleton sidekick Geoff Peterson (voiced by Josh Robert Thompson), and featuring Secretariat, a pantomime horse. The shows writers and other staff appeared in skits and as themselves occasionally, with show producer Michael Naidus becoming a regular. 2,058 episodes were produced.

## 2005
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1 | January 3, 2005 (2005-01-03) | David Duchovny, Nicole Sullivan | N/A |
| One of Ferguson's first guests is Nicole Sullivan, coincidentally the first woman Ferguson dated when he came to the United States from Scotland in 1994. ||||
| 2 | January 4, 2005 (2005-01-04) | Jon Cryer, Sophie Okonedo | Keb' Mo' |
| 3 | January 5, 2005 (2005-01-05) | Julian McMahon, Aisha Tyler | Howie Day performed "Colide" from Stop All The World Now |
| 4 | January 6, 2005 (2005-01-06) | Jason Alexander, Hau Thai-Tang | The Donnas performed "I Don't Want to Know (If You Don't Want Me)" from Gold Medal |
| 5 | January 7, 2005 (2005-01-07) | Jeremy Piven | G. Love |
| 6 | January 10, 2005 (2005-01-10) | John Goodman, Emmy Rossum | N/A |
| Ferguson performed in a sketch as Super Mario. ||||
| 7 | January 11, 2005 (2005-01-11) | Little Richard, William H. Macy | Little Richard performs "Baby What You Want Me to Do" from 1966's The Wild and Frantic Little Richard, and "Tutti Frutti" from 1955's Here's Little Richard |
| 8 | January 12, 2005 (2005-01-12) | James Woods, Amanda Bynes | Comedian Jim Short |
| 9 | January 13, 2005 (2005-01-13) | Teri Polo, Eddie Steeples | Wyclef Jean |
| 10 | January 14, 2005 (2005-01-14) | Patricia Arquette, Peter Guber, Peter Bart | N/A |
| 11 | January 17, 2005 (2005-01-17) | Renée Fleming | Mos Def performs "The Painties" from The New Danger |
| 12 | January 18, 2005 (2005-01-18) | Regis Philbin, Rob Morrow | Billy Bragg performs ""Waiting for the Great Leap Forwards" from Workers Playtime |
| 13 | January 19, 2005 (2005-01-19) | Minnie Driver, Candace Bushnell | N/A |
| 14 | January 20, 2005 (2005-01-20) | Samuel L. Jackson, Maria Bello | Collective Soul performs "How Do You Love" from Youth |
| 15 | January 21, 2005 (2005-01-21) | Tara Reid, Crispin Glover | The Ditty Bops perform "There's A Girl" from their self-titled album |
| 16 | January 24, 2005 (2005-01-24) | Jim Belushi, Kim Raver | DramaGods perform "So'k" from Love |
| 17 | January 25, 2005 (2005-01-25) | Famke Janssen, Joe Montana | Comedian Richard Jeni |
| 18 | January 26, 2005 (2005-01-26) | Blythe Danner | Comedian Stewart Francis |
| 19 | January 27, 2005 (2005-01-27) | Ice Cube, Steve Jones | French Kicks perform the title track from The Trial of the Century |
| 20 | January 28, 2005 (2005-01-28) | Vanessa L. Williams, Scott Wolf | Razorlight performs "Somewhere Else" from Up All Night |
| 21 | January 31, 2005 (2005-01-31) | Katey Sagal, Christine Barrett, Jake Shears | Scissor Sisters performed "Filthy/Gorgeous" from their self-titled album |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 22 | February 1, 2005 (2005-02-01) | John Larroquette, Jennifer Finnigan | Comedian Rickey Smiley |
| 23 | February 2, 2005 (2005-02-02) | Joe Mantegna, Stan Lee | Emma Bunton perform "Crickets Sing for Anamaria" |
| 24 | February 3, 2005 (2005-02-03) | Peter Gallagher, Laila Ali | ...And You Will Know Us by the Trail of Dead perform "The Rest Will Follow" from Worlds Apart |
| 25 | February 4, 2005 (2005-02-04) | Jeff Gordon, Philip Daniel Bolden | Comedian Andrew Donnelly |
| 26 | February 7, 2005 (2005-02-07) | Patti LaBelle, Imelda Staunton | Night Ranger perform "Sister Christian" from Midnight Madness |
| 27 | February 8, 2005 (2005-02-08) | Randy Jackson, Samantha Daniels | Comedian Greg Proops |
| 28 | February 9, 2005 (2005-02-09) | Laura Linney, Barry Watson, Laura Margolis, Kevin O'Connell | N/A |
| 29 | February 10, 2005 (2005-02-10) | Star Jones, Amber Valletta | The Zutons perform "Confusion" from Who Killed...... The Zutons? |
| 30 | February 11, 2005 (2005-02-11) | Alan Alda, Tori Spelling | Steve Earle performs "The Revolution Starts" from The Revolution Starts... Now |
| 31 | February 14, 2005 (2005-02-14) | Jane Seymour, Paul Haggis | Bright Eyes perform "Road to Joy" from I'm Wide Awake, It's Morning |
| 32 | February 15, 2005 (2005-02-15) | Mimi Rogers, James Denton, Courtney Hansen | N/A |
| 33 | February 16, 2005 (2005-02-16) | Jennifer Beals, David Krumholtz | Interpol perform "Evil" from Antics |
| 34 | February 17, 2005 (2005-02-17) | Sean Astin, Kathryn Morris | Madeleine Peyroux performs "Dance Me to the End of Love" from Careless Love |
| 35 | February 18, 2005 (2005-02-18) | Julian Fellowes, Janet Ferguson, Andy Dick, | Comedian Paul Gilmartin |
| Ferguson's mother, Janet Ferguson visits LA sites with Wu Tang Clan's RZA ||||
| 36 | February 21, 2005 (2005-02-21) | Bob Schieffer, John C. McGinley | Ani DiFranco performs "Recoil" from Knuckle Down |
| 37 | February 22, 2005 (2005-02-22) | Peter Boyle, Jenna Morasca, Ethan Zohn | Brian McKnight performs "Everything I Do" from Gemini |
| 38 | February 23, 2005 (2005-02-23) | Thomas Haden Church, Don King | Comedienne Maria Bamford |
| 39 | February 24, 2005 (2005-02-24) | Jami Gertz, Steven Wright | Sum 41 perform "No Reason" from Chuck |
| 40 | February 25, 2005 (2005-02-25) | Faye Dunaway, Andrew Wight | Nuttin' But Stringz perform the title track from Dance with My Father |
| 41 | February 28, 2005 (2005-02-28) | Amy Brenneman | Paul Westerberg performs "As Far as I Know" from Another Year on the Streets, Vol. 3 |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 42 | March 1, 2005 (2005-03-01) | Don Rickles, Missy Elliott | Judith Owen performs "These Foolish Things" |
| 43 | March 2, 2005 (2005-03-02) | Jeff Probst, Emily Mortimer | Comedian Danny Bhoy |
| 44 | March 3, 2005 (2005-03-03) | Juliette Binoche, Lara Logan, Stanley Bing | N/A |
| 45 | March 4, 2005 (2005-03-04) | Jennifer Love Hewitt, Dave Foley, Ali Costello | Unwritten Law performs "Save Me (Wake Up Call)" from Here's to the Mourning |
| 46 | March 14, 2005 (2005-03-14) | Joan Collins, Phil Keoghan | The Blue Nile performs "I Would Never" from High |
| 47 | March 15, 2005 (2005-03-15) | Drew Carey, Lawrence Block | The Hollow Men perform "Pink Panther" |
| 48 | March 16, 2005 (2005-03-16) | Kevin Pollak, Maureen Dowd | Deana Carter performs "One Day at a Time" from The Story of My Life |
| 49 | March 21, 2005 (2005-03-21) | Michael Chiklis, Tony Hawk | Nic Armstrong & The Thieves performed "I Can't Stand It" |
| 50 | March 22, 2005 (2005-03-22) | Sam Elliott, Amy Yasbeck | Comedian Bob Marley |
| 51 | March 23, 2005 (2005-03-23) | Andie MacDowell, Gerard Butler | Kathleen Edwards performs the title track from Back to Me |
| 52 | March 28, 2005 (2005-03-28) | Wendie Malick, Chris Klug | Lisa Loeb performs "Catch the Moon" from The Way It Really Is |
| 53 | March 29, 2005 (2005-03-29) | Robert Rodriguez, Stone Cold Steve Austin | k-os performs "Crabbuckit" from Joyful Rebellion |
| 54 | March 30, 2005 (2005-03-30) | Carmen Electra, Nick Stahl | Lang Lang |
| 55 | March 31, 2005 (2005-03-31) | Bernie Mac, Mädchen Amick, Rachael Scdoris | N/A |

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 56 | April 1, 2005 (2005-04-01) | Carla Gugino, Regina King, Elon Gold | N/A |
| 57 | April 4, 2005 (2005-04-04) | Jimmy Smits | Moby performs "Lift Me Up" from Hotel |
| 58 | April 5, 2005 (2005-04-05) | Michael Clarke Duncan, Mary McCormack | Comedienne Becky Pedigo |
| 59 | April 6, 2005 (2005-04-06) | Ron Livingston, Dave Gorman | Jesse McCartney performs "She's No You" from Beautiful Soul |
| 60 | April 11, 2005 (2005-04-11) | Amber Tamblyn, Jason Lee, Steven Hensley | N/A |
| 61 | April 12, 2005 (2005-04-12) | Eric Idle, Rulon Gardner | Comedian Mike Birbiglia |
| 62 | April 13, 2005 (2005-04-13) | Sara Rue, Matthew Polly | Aqualung performs "Brighter Than Sunshine" from Still Life |
| 63 | April 14, 2005 (2005-04-14) | Fran Drescher, Anton Yelchin | Shooter Jennings performs "4th of July" from Put the "O" Back in Country |
| 64 | April 15, 2005 (2005-04-15) | David Duchovny, Ryan Reynolds | Dinosaur Jr. performs "The Lung" from You're Living All Over Me |
| 65 | April 25, 2005 (2005-04-25) | Suzanne Somers, Erykah Badu, Billy Miles | N/A |
| 66 | April 26, 2005 (2005-04-26) | Thandie Newton, Barb MacLeod | N/A |
| 67 | April 27, 2005 (2005-04-27) | Paul Haggis, Michael Gelbart | Gavin Rossdale performs "The Current" from The Complex |
| 68 | April 28, 2005 (2005-04-28) | Rosie O'Donnell, Akiane Kramarik | N/A |
| 69 | April 29, 2005 (2005-04-29) | Anjelica Huston, Danny Pino | The Futureheads perform "Hounds of Love" from their self-titled album |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 70 | May 2, 2005 (2005-05-02) | Jonathan Rhys Meyers, Ben Stein | Kasabian performs "Cutt Off" from their self-titled album |
| 71 | May 3, 2005 (2005-05-03) | Bill Maher, Rain Pryor | Comedian Stewart Francis |
| 72 | May 4, 2005 (2005-05-04) | Gary Sinise, Dean Karnazes | Ben Folds performs "Landed" from Songs for Silverman |
| 73 | May 5, 2005 (2005-05-05) | Ozzy Osbourne, Allison DuBois | Brendan Benson performs "What I'm Looking For" from The Alternative to Love |
| 74 | May 6, 2005 (2005-05-06) | Jim Caviezel, Phil Lesh | Eels performs "Hey Man (Now You're Really Living)" from Blinking Lights and Other Revelations |
| 75 | May 9, 2005 (2005-05-09) | Mark Harmon, Rza | Joss Stone performs "Spoiled" from Mind, Body & Soul |
| 76 | May 10, 2005 (2005-05-10) | Rose McGowan, Dr. Sanjay Gupta | Charlie Daniels performs a song from Songs From the Longleaf Pines |
| 77 | May 11, 2005 (2005-05-11) | Kermit the Frog, Leelee Sobieski | Tori Amos performs "Sleeps with Butterflies" from The Beekeeper |
| 78 | May 12, 2005 (2005-05-12) | Bill Pullman, Ruth Reichl | Spoon performs "Sister Jack" from Gimme Fiction |
| 79 | May 13, 2005 (2005-05-13) | Wanda Sykes, Eric Bogosian | N/A |
| 80 | May 16, 2005 (2005-05-16) | Mike Huckabee, Marlee Matlin | John Butler Trio performs "Something's Gotta Give" |
| 81 | May 17, 2005 (2005-05-17) | Joe Walsh, George Eads | Junior Brown performs a song from Down Home Chrome |
| 82 | May 18, 2005 (2005-05-18) | Sela Ward, Michael Tucker | Acceptance performs "In Too Fair" from Phantoms |
| 83 | May 19, 2005 (2005-05-19) | Phil McGraw | Ringside performs "Tired of Being Sorry" from their self-titled album |
| 84 | May 20, 2005 (2005-05-20) | Randy Jackson, Bai Ling, Gary Greff | N/A |
| 85 | May 23, 2005 (2005-05-23) | Ann Coulter, Amber Mariano, Rob Mariano | Comedian Charles Ross |
| 86 | May 24, 2005 (2005-05-24) | Alice Cooper, Malachy McCourt | Dierks Bentley performs "Settle for a Slowdown" from Modern Day Drifter |
| 87 | May 25, 2005 (2005-05-25) | Donny Osmond, Peter Bart | Robert Cray performs the title track from Twenty |
| 88 | May 26, 2005 (2005-05-26) | Rachael Leigh Cook, Chuck Palahniuk | Layzie Bone performs a song from The New Revolution |
| 89 | May 27, 2005 (2005-05-27) | Seth Green, Tony Alva | The Daylights perform a song from Shift and Blur |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 90 | June 6, 2005 (2005-06-06) | Jon Cryer, Garrison Keillor | Sound of Urchin performs a song from The Diamond |
| 91 | June 7, 2005 (2005-06-07) | Marg Helgenberger, David Milch | Jaguares performs a song from Crónicas de un Laberinto |
| 92 | June 8, 2005 (2005-06-08) | Dennis Hopper, Marianne Jean-Baptiste | Comedian Carlos Alazraqui |
| 93 | June 9, 2005 (2005-06-09) | Ricky Schroder | Toby Keith performs "Honkytonk U" from Honkytonk University |
| 94 | June 10, 2005 (2005-06-10) | Vivica A. Fox, Poppy Montgomery | Angie Stone performs "U-Haul" from Stone Love |
| 95 | June 13, 2005 (2005-06-13) | Jason Lee, Drew Pinsky | Midlake performs "Mornings Will Be Kind" |
| 96 | June 14, 2005 (2005-06-14) | Cheryl Ladd, Skeet Ulrich | Kaiser Chiefs performs "Everyday I Love You Less and Less" |
| 97 | June 15, 2005 (2005-06-15) | Steven Wright, John F. Banzhaf III Skit with James Adomian as George W. Bush | Comedian Steven Wright Amos Lee performs "Keep It Loose, Keep It Tight" from his eponymous album |
| 98 | June 16, 2005 (2005-06-16) | Tommy Hilfiger, Lea Thompson | Nikka Costa performs "Till I Get to You" from Can'tneverdidnothin' |
| 99 | June 17, 2005 (2005-06-17) | Debbie Reynolds, Thomas Lennon, Nick Hornby | TBA |
| 100 | June 20, 2005 (2005-06-20) | Allison Janney, Julian Sands | Rilo Kiley performs a song from More Adventurous |
| 101 | June 21, 2005 (2005-06-21) | Peter Krause, David LaChapelle | Tracy Bonham performs "Shine" from Blink the Brightest |
| "Host-whisperer" Peter Lassally, veteran producer of The Tonight Show with Johnny Carson and for David Letterman takes over the day-to-day running of the show as executive producer. Lassally was largely responsible for hiring Ferguson, and had been coaching him in his new role. ||||
| 102 | June 22, 2005 (2005-06-22) | John Waters, Loretta Devine | Comedian Demetri Martin |
| 103 | June 23, 2005 (2005-06-23) | Mimi Rogers, James Ellroy | Brooke Valentine performs "Girlfight" from Chain Letter |
| 104 | June 24, 2005 (2005-06-24) | Jeremy Piven, Melissa Bank | Mike Jones performs "Flossin" from Who Is Mike Jones? |
| 105 | June 27, 2005 (2005-06-27) | Bryan Cranston, Peter Guber | The Krumpers perform a dance routine |
| 106 | June 28, 2005 (2005-06-28) | Amy Yasbeck, Ringo Starr | Ringo Starr and His All-Starr Band perform the title track from "Choose Love" and "I'm the Greatest" from his 1973 album Ringo |
| 107 | June 29, 2005 (2005-06-29) | Kara Cooney | Dwight Yoakam perform a song from Blame the Vain |
| 108 | June 30, 2005 (2005-06-30) | Jennifer Tilly, Corbin Bernsen, Leroy Chiao | TBA |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 109 | July 1, 2005 (2005-07-01) | Tom Bergeron, Greg Nicotero | Billy Bragg performs a song from Volume 1 |
| 110 | July 11, 2005 (2005-07-11) | Julian McMahon, Rachel DeWoskin | The Crystal Method performs a song from Legion of Boom. |
| 111 | July 12, 2005 (2005-07-12) | Dave Navarro, Marisa Marchetto | Comedian Ron Pearson |
| 112 | July 13, 2005 (2005-07-13) | Tony Shalhoub, Jared Diamond | Raul Midón performs a song from State of Mind |
| 113 | July 14, 2005 (2005-07-14) | Beau Bridges, Harry Eden | Comedienne Martha Kelly |
| 114 | July 15, 2005 (2005-07-15) | John Larroquette, Dan Huber | Fountains of Wayne performs a song from Out-of-State Plates |
| 115 | July 18, 2005 (2005-07-18) | Wolf Blitzer, Karina Lombard | Nellie McKay performs "Pasadena Girl" from the soundtrack of Rumor Has It... |
| 116 | July 19, 2005 (2005-07-19) | Ludacris, Julie Warner | Comedian Ty Barnett |
| 117 | July 20, 2005 (2005-07-20) | Dave Foley, Marc Horowitz | Tionne "T-Boz" Watkins and Rozonda "Chilli" Thomas from R U the Girl |
| 118 | July 21, 2005 (2005-07-21) | Warren Faidley, Martin Mull | Chef Preston Clarke |
| 119 | July 22, 2005 (2005-07-22) | Camryn Manheim, Elizabeth Banks | Crossfade performs "So Far Away" from Crossfade |
| 120 | July 25, 2005 (2005-07-25) | Eddie Izzard, R. James Woolsey Jr. | Elkland performs a song from Golden |
| 121 | July 26, 2005 (2005-07-26) | Peter Arnett, Isla Fisher | Comedienne Wendy Liebman |
| 122 | July 27, 2005 (2005-07-27) | Joe Buck, Pauley Perrette | N/A |
| 123 | July 28, 2005 (2005-07-28) | Dermot Mulroney, Paul Feig | N/A |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 124 | August 1, 2005 (2005-08-01) | Cloris Leachman, Mark Zupan | Comedian Carlos Mencia |
| 125 | August 2, 2005 (2005-08-02) | Jane Kaczmarek, John Carroll Lynch | Comedian Greg Proops |
| 126 | August 3, 2005 (2005-08-03) | Joseph Fiennes, Julie Chen | Tracy Bonham performs "Did I Sleep Through It All?" from Blink the Brightest |
| 127 | August 4, 2005 (2005-08-04) | Sharon Stone, Mo'Nique | N/A |
| 128 | August 5, 2005 (2005-08-05) | Buzz Aldrin, Method Man, John Mendoza | N/A |
| 129 | August 8, 2005 (2005-08-08) | Marilu Henner, David Feherty | N/A |
| 130 | August 9, 2005 (2005-08-09) | Harland Williams, Evan Rachel Wood | Babyface performs the single "Reason for Breathing" |
| 131 | August 10, 2005 (2005-08-10) | Kristin Chenoweth, Marc Cherry | Natasha Bedingfield performs "I Bruise Easily" from Unwritten |
| 132 | August 15, 2005 (2005-08-15) | Hank Azaria, Wes Craven | N/A |
| 133 | August 16, 2005 (2005-08-16) | Rachel Griffiths, Tommy Lasorda | Comedian D. C. Benny |
| 134 | August 17, 2005 (2005-08-17) | Arianna Huffington, Gigi Grazer | Comedian Louis C.K. |
| 135 | August 18, 2005 (2005-08-18) | Jami Gertz, Steve Howey | Missy Higgins performs the title track from The Sound of White |
| 136 | August 19, 2005 (2005-08-19) | Steve Carell, Rashida Jones, Rick Lundblade | N/A |
| 137 | August 22, 2005 (2005-08-22) | Carl Reiner, Rosa Blasi | Rufus Wainwright performs "The One You Love" from Want Two |
| 138 | August 23, 2005 (2005-08-23) | Minnie Driver, Todd Zeile | N/A |
| 139 | August 24, 2005 (2005-08-24) | Eric McCormack, Mitch Albom | N/A |
| 140 | August 25, 2005 (2005-08-25) | Carrie Fisher, Terry McDermott | Our Lady Peace performs "Where Are You" from Healthy in Paranoid Times |
| 141 | August 26, 2005 (2005-08-26) | Felicity Huffman, Stanley Bing | Last Train Home performs |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 142 | September 12, 2005 (2005-09-12) | Neil Patrick Harris, Karen Fisher | Nickel Creek |
| 143 | September 13, 2005 (2005-09-13) | Bruce Campbell, Melinda Clarke | Flight of the Conchords |
| 144 | September 14, 2005 (2005-09-14) | Patricia Arquette, Connie Schultz | Paul Weller |
| 145 | September 15, 2005 (2005-09-15) | Carla Gugino, Alice Cooper | N/A |
| 146 | September 16, 2005 (2005-09-16) | Alyson Hannigan, Steve Jones | N/A |
| 147 | September 19, 2005 (2005-09-19) | Cybill Shepherd, Phil Keoghan | Institute |
| 148 | September 20, 2005 (2005-09-20) | Tyra Banks, Tyler James Williams | Ted Alexandro |
| 149 | September 21, 2005 (2005-09-21) | Nick Cannon, Jeff Probst, Lawrence Turman | N/A |
| 150 | September 22, 2005 (2005-09-22) | Aisha Tyler, Seth MacFarlane | Thirty Seconds to Mars |
| 151 | September 23, 2005 (2005-09-23) | Susan Sarandon, Tom Everett Scott | INXS |
| 152 | September 26, 2005 (2005-09-26) | Danny Bonaduce, Diane Farr | Shaggy |
| 153 | September 27, 2005 (2005-09-27) | Maria Bello, Jason Segel | N/A |
| 154 | September 28, 2005 (2005-09-28) | Alan Alda, Jennifer Coolidge | N/A |
| 155 | September 29, 2005 (2005-09-29) | Fran Drescher, Robert David Hall | Jo Dee Messina |
| 156 | September 30, 2005 (2005-09-30) | Toni Collette, Dave Price | Robert Plant & Strange Sensation |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 157 | October 3, 2005 (2005-10-03) | Julian McMahon, Jennifer Finnigan | North Mississippi Allstars |
| 158 | October 4, 2005 (2005-10-04) | Taryn Manning, Dr. Drew | Butch Bradley |
| 159 | October 5, 2005 (2005-10-05) | David Duchovny | Sinéad O'Connor |
| 160 | October 6, 2005 (2005-10-06) | Henry Winkler, Aron Ralston | Julie Gribble |
| 161 | October 7, 2005 (2005-10-07) | Illeana Douglas | Macy Gray |
| 162 | October 10, 2005 (2005-10-10) | Macy Gray, Nuala O'Faolain | Rihanna |
| 163 | October 11, 2005 (2005-10-11) | Dennis Hopper, Cheryl Hines | Sarge |
| 164 | October 12, 2005 (2005-10-12) | Joe Mantegna, Sue Johanson | N/A |
| 165 | October 13, 2005 (2005-10-13) | Sanjay Gupta, Stephen Collins | N/A |
| 166 | October 14, 2005 (2005-10-14) | Bill Nye, Kevin Bacon & Michael Bacon | Bacon Brothers |
| 167 | October 17, 2005 (2005-10-17) | Joely Fisher, McG | Switchfoot |
| 168 | October 18, 2005 (2005-10-18) | Melina Kanakaredes, Stephen Robinson | N/A |
| 169 | October 19, 2005 (2005-10-19) | Betty White, Rhona Mitra | Ray J |
| 170 | October 20, 2005 (2005-10-20) | Stockard Channing, Michael Connelly | Jamie Cullum |
| 171 | October 21, 2005 (2005-10-21) | Jason Schwartzman, Mitch Braswell | Paul Weller |
| 172 | October 31, 2005 (2005-10-31) | Sharon Osbourne | N/A |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 173 | November 1, 2005 (2005-11-01) | Maria Bartiromo, Jamie Kaler | Clint Black |
| 174 | November 2, 2005 (2005-11-02) | Anthony LaPaglia, Jeri Ryan | N/A |
| 175 | November 3, 2005 (2005-11-03) | Charlie Sheen, Marissa Jaret Winokur | Franz Ferdinand |
| 176 | November 4, 2005 (2005-11-04) | Gina Gershon, Rob Zombie | Sinéad O'Connor |
| 177 | November 7, 2005 (2005-11-07) | Hugh Laurie, Twiggy | Patty Loveless |
| 178 | November 8, 2005 (2005-11-08) | Brenda Blethyn, Jim Sheridan | John Roy |
| 179 | November 9, 2005 (2005-11-09) | John Leguizamo, Kara Cooney | My Morning Jacket |
| 180 | November 10, 2005 (2005-11-10) | John Malkovich | N/A |
| 181 | November 11, 2005 (2005-11-11) | Xzibit, Doug Savant | Buddy Guy |
| 182 | November 14, 2005 (2005-11-14) | James Belushi, Parminder Nagra | Matisyahu |
| 183 | November 15, 2005 (2005-11-15) | Patti Smith, John Lahr | N/A |
| 184 | November 16, 2005 (2005-11-16) | Anne Heche, Tom Amandes | Jay Larson |
| 185 | November 17, 2005 (2005-11-17) | RZA, Josh Schwartz | Amos Lee |
| 186 | November 18, 2005 (2005-11-18) | Jon Favreau, Randy Cohen | Maz Jobrani |
| 187 | November 21, 2005 (2005-11-21) | Juliette Lewis, Brian Van Holt | Juliette and the Licks |
| 188 | November 22, 2005 (2005-11-22) | Jerry O'Connell, Joely Richardson | The Fray |
| 189 | November 23, 2005 (2005-11-23) | Regis Philbin, Maureen Dowd | N/A |
| 190 | November 24, 2005 (2005-11-24) | Jennifer Love Hewitt, James Denton | Robert Plant |
| 191 | November 25, 2005 (2005-11-25) | Danny Bonaduce, Paul Haggis | N/A |
| 192 | November 28, 2005 (2005-11-28) | Ted Danson, Kristen Bell | Matt Fulchiron |
| 193 | November 29, 2005 (2005-11-29) | Sela Ward, Lawrence O'Donnell | Chris Botti, Paul Buchanan |
| 194 | November 30, 2005 (2005-11-30) | Tony Shalhoub, Mitch Albom | N/A |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 195 | December 1, 2005 (2005-12-01) | Miranda Lambert, Malachy McCourt | Miranda Lambert |
| 196 | December 2, 2005 (2005-12-02) | Tom Arnold, Helen Fielding | Lifehouse |
| 197 | December 12, 2005 (2005-12-12) | Jon Cryer, Amy Yasbeck | N/A |
| 198 | December 13, 2005 (2005-12-13) | John Waters, David Steinberg | Nada Surf |
| 199 | December 14, 2005 (2005-12-14) | Poppy Montgomery, Mancow (Band) | N/A |
| 200 | December 15, 2005 (2005-12-15) | Michelle Yeoh, Jeremy Roenick | Trey Anastasio |
| 201 | December 16, 2005 (2005-12-16) | Chris Isaak, Sara Gilbert | Keaton Simons |
| 202 | December 19, 2005 (2005-12-19) | Dennis Quaid, Bill Nye | Bob Marley |
| 203 | December 20, 2005 (2005-12-20) | Dwight Yoakam, Teri Garr | N/A |
| 204 | December 21, 2005 (2005-12-21) | Little Richard, Brian Cox | N/A |
| 205 | December 22, 2005 (2005-12-22) | Téa Leoni, Amy Tan | RZA |
| 206 | December 23, 2005 (2005-12-23) | Katey Sagal, Colin Hanks | Brian McKnight |

## 2006
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 207 | January 2, 2006 (2006-01-02) | Drew Pinsky, Bob Spitz | N/A |
| 208 | January 3, 2006 (2006-01-03) | Fred Willard, Connie Schultz | N/A |
| 209 | January 4, 2006 (2006-01-04) | Rob Morrow | Bob Marley |
| 210 | January 5, 2006 (2006-01-05) | Don Rickles, Ivana Miličević | Aimee Mann |
| 211 | January 6, 2006 (2006-01-06) | Daryl Hannah, Thomas Lennon | N/A |
| 212 | January 9, 2006 (2006-01-09) | Cheryl Hines, Derek Luke | Trey Anastasio |
| 213 | January 10, 2006 (2006-01-10) | Dr Phil McGraw | Sebastian Maniscalco |
| 214 | January 11, 2006 (2006-01-11) | Seth Green, Peter Bart, Peter Guber | N/A |
| 215 | January 12, 2006 (2006-01-12) | Tom Selleck, Connie Britton | Ian Edwards |
| 216 | January 13, 2006 (2006-01-13) | Steven Wright, Lola Glaudini | Anthony Hamilton |
| 217 | January 16, 2006 (2006-01-16) | Allison Janney, John C. McGinley | The 88 |
| 218 | January 17, 2006 (2006-01-17) | Greg Kinnear, Paula Poundstone | Ming Tsai |
| 219 | January 18, 2006 (2006-01-18) | Thomas Cavanagh | N/A |
| 220 | January 19, 2006 (2006-01-19) | Vanessa Williams | Rogue Wave |
| 221 | January 20, 2006 (2006-01-20) | Mimi Rogers | Living Things |
| 222 | January 30, 2006 (2006-01-30) | Drew Pinsky, Amy Yasbeck | Wicked Tinkers |
| In this more serious episode, Ferguson memorably eulogizes his father, Robert Ferguson. ||||
| 223 | January 31, 2006 (2006-01-31) | Jim Belushi, Parminder Nagra | Matisyahu |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 224 | February 1, 2006 (2006-02-01) | James Woods, Piper Perabo | Keaton Simons |
| 225 | February 2, 2006 (2006-02-02) | Emma Thompson, Steve Byrne | N/A |
| 226 | February 3, 2006 (2006-02-03) | Lynn Redgrave, Isaiah Washington | Mutemath |
| 227 | February 6, 2006 (2006-02-06) | Mary Steenburgen | Big & Rich |
| 228 | February 7, 2006 (2006-02-07) | Jeff Probst, Lauren Holly | Ne-Yo |
| 229 | February 8, 2006 (2006-02-08) | Zooey Deschanel | Trace Adkins |
| 230 | February 9, 2006 (2006-02-09) | Jean Reno, Sanaa Lathan | N/A |
| 231 | February 10, 2006 (2006-02-10) | Eddie Izzard, Patti Hall | N/A |
| 232 | February 13, 2006 (2006-02-13) | Alyson Hannigan, Paul Haggis | Frank Caliendo |
| 233 | February 14, 2006 (2006-02-14) | Marlee Matlin | Lisa Loeb |
| 234 | February 15, 2006 (2006-02-15) | Paul Reiser, Judy Greer | Jeff Cesario |
| 235 | February 16, 2006 (2006-02-16) | Kiefer Sutherland, Amy Adams | Rocco DeLuca and the Burden |
| 236 | February 17, 2006 (2006-02-17) | Jason Biggs | Fiona Apple |
| 237 | February 20, 2006 (2006-02-20) | William Shatner, Josh Bernstein | Andrea Bocelli |
| 238 | February 21, 2006 (2006-02-21) | Carl Reiner, Nadine Velazquez | Robert Hawkins |
| 239 | February 22, 2006 (2006-02-22) | Carl Edwards, William H. Macy | N/A |
| 240 | February 23, 2006 (2006-02-23) | Samuel L. Jackson, Cokie Roberts | The Lashes |
| 241 | February 24, 2006 (2006-02-24) | Dolly Parton, Kevin Smith | The Cult |
| 242 | February 27, 2006 (2006-02-27) | Terrence Howard, Eric Haney | N/A |
| 243 | February 28, 2006 (2006-02-28) | Regis Philbin, Tichina Arnold | Jenny Lewis & the Watson Twins (Band) |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 244 | March 1, 2006 (2006-03-01) | Roseanne Barr, Wolfgang Puck | N/A |
| 245 | March 2, 2006 (2006-03-02) | Kathy Bates, Idina Menzel, Jeremy Bloom | N/A |
| 246 | March 3, 2006 (2006-03-03) | Milla Jovovich, Peter Travers | All American Rejects |
| 247 | March 6, 2006 (2006-03-06) | Paul Haggis, Ben Lee, James Blake | N/A |
| 248 | March 7, 2006 (2006-03-07) | Tyra Banks, Jackie Collins, Nathan Sawaya | N/A |
| 249 | March 8, 2006 (2006-03-08) | John Larroquette, Ethan Suplee | Fiona Apple |
| 250 | March 9, 2006 (2006-03-09) | Wynonna, Emilie de Ravin | D. C. Benny |
| 251 | March 10, 2006 (2006-03-10) | David Arquette | Cowboy Troy |
| 252 | March 20, 2006 (2006-03-20) | Stockard Channing | Big & Rich |
| 253 | March 21, 2006 (2006-03-21) | Rosanne Cash, Howie Mandel | N/A |
| 254 | March 22, 2006 (2006-03-22) | Jason Lee, Julian Sands | David Gray |
| 255 | March 27, 2006 (2006-03-27) | Joan Cusack, Mary McCormack | The New Cars |
| 256 | March 28, 2006 (2006-03-28) | Jane Kaczmarek, Tom Fontana | Dan Naturman |
| 257 | March 29, 2006 (2006-03-29) | John Goodman, Angela Nissel | Alkaline Trio |
| 258 | March 30, 2006 (2006-03-30) | Frankie Muniz, Annie Duke | N/A |
| 259 | March 31, 2006 (2006-03-31) | Chris Kattan, Mo'Nique | Ozomatli |

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 260 | April 3, 2006 (2006-04-03) | Mehcad Brooks, Anjelica Huston | Ne-Yo |
| 261 | April 4, 2006 (2006-04-04) | Rosie O'Donnell, Harry Shearer | N/A |
| 262 | April 5, 2006 (2006-04-05) | Paget Brewster, Sam Elliott | Adam Ferrara |
| 263 | April 6, 2006 (2006-04-06) | Ben Kingsley, Roselyn Sánchez | UB40 |
| 264 | April 7, 2006 (2006-04-07) | Kevin Pollak, Mira Sorvino | Train |
| 265 | April 10, 2006 (2006-04-10) | Christian Finnegan, Chi McBride, Bebe Neuwirth | N/A |
| 266 | April 11, 2006 (2006-04-11) | Carrie Fisher | John Corbett |
| 267 | April 12, 2006 (2006-04-12) | Carl Hiaasen, Toby Keith | N/A |
| 268 | April 13, 2006 (2006-04-13) | Roger Lay Jr., Ray Romano, Ken Shamrock | N/A |
| 269 | April 14, 2006 (2006-04-14) | Melina Kanakaredes, Kyle MacLachlan | Shinedown |
| 270 | April 24, 2006 (2006-04-24) | Dennis Quaid | The Wiggles |
| 271 | April 25, 2006 (2006-04-25) | Radha Mitchell, Marion Ross | Erin Boheme |
| 272 | April 26, 2006 (2006-04-26) | Jennifer Finnigan, Barry Sonnenfeld | N/A |
| 273 | April 27, 2006 (2006-04-27) | Dave Barry | Dem Franchize Boyz |
| 274 | April 28, 2006 (2006-04-28) | Kristin Chenoweth, Andy García, Mandy Moore | Rock Bottom Remainders |
| Ferguson returns to his punk rock roots to play the drums with the Rock Bottom Remainders. ||||

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 275 | May 1, 2006 (2006-05-01) | Neil Patrick Harris, Parminder Nagra | The BellRays |
| 276 | May 2, 2006 (2006-05-02) | Randy Jackson, Connie Schultz | N/A |
| 277 | May 3, 2006 (2006-05-03) | Reggie Bush, Jennifer Love Hewitt, Frank McCourt | Secret Machines |
| 278 | May 4, 2006 (2006-05-04) | Emily Deschanel, Kelsey Grammer, Aisha Tyler | The Go! Team |
| 279 | May 5, 2006 (2006-05-05) | Julia Louis-Dreyfus | Ying-Yang Twins |
| 280 | May 8, 2006 (2006-05-08) | Denis Leary | Bo Bice |
| 281 | May 9, 2006 (2006-05-09) | Donald Faison, Betty White | Bill Bailey |
| 282 | May 10, 2006 (2006-05-10) | Bill Carter, Jenna Fischer | Chris Isaak |
| 283 | May 11, 2006 (2006-05-11) | Paul Bettany, Kate Walsh | Damian Marley |
| 284 | May 12, 2006 (2006-05-12) | Jacinda Barrett, Mark Harmon | Rock Kills Kid |
| 285 | May 15, 2006 (2006-05-15) | Daryl Hannah | Sara Ramirez |
| 286 | May 16, 2006 (2006-05-16) | Phil McGraw | Jim Gaffigan |
| 287 | May 17, 2006 (2006-05-17) | Merv Griffin, Rick Reilly | N/A |
| 288 | May 18, 2006 (2006-05-18) | Diane Farr, Dominic Monaghan | Phil Vassar |
| 289 | May 19, 2006 (2006-05-19) | Mía Maestro | Nick Lachey |
| 290 | May 22, 2006 (2006-05-22) | Reba McEntire, Cynthia Watros | Toby Keith |
| 291 | May 23, 2006 (2006-05-23) | Anna Paquin, Casper Van Dien | Jason Aldean |
| 292 | May 24, 2006 (2006-05-24) | Ricki Lake, Oscar De La Hoya | The Wreckers |
| 293 | May 25, 2006 (2006-05-25) | Pauley Perrette | Brooks and Dunn |
| 294 | May 26, 2006 (2006-05-26) | Jenny McCarthy, Jim Short | Gomez |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 295 | June 5, 2006 (2006-06-05) | Jon Favreau, Shooter Jennings, Lee Child | N/A |
| 296 | June 6, 2006 (2006-06-06) | Patricia Heaton, Claire Fordham | The New Cars |
| 297 | June 7, 2006 (2006-06-07) | Ian McShane, Joey Lauren Adams, Stanley Bing | N/A |
| 298 | June 8, 2006 (2006-06-08) | Edie Falco, David Lee Roth | N/A |
| 299 | June 9, 2006 (2006-06-09) | Tom Everett Scott | Ludacris, Speech |
| 300 | June 12, 2006 (2006-06-12) | Sara Rue, Anthony Michael Hall | Secret Machines |
| 301 | June 13, 2006 (2006-06-13) | Anderson Cooper, Mercedes Ruehl | Dan Cummins |
| 302 | June 14, 2006 (2006-06-14) | Lorraine Bracco, Kevin Connolly, Jamie Jenson | N/A |
| 303 | June 15, 2006 (2006-06-15) | Tony Shalhoub, Lucy Davis | Echo & the Bunnymen |
| 304 | June 16, 2006 (2006-06-16) | Jon Cryer, Jim Short | Three Days Grace |
| 305 | June 19, 2006 (2006-06-19) | Pepe the King Prawn, Sarah Wynter | The Charlatans |
| 306 | June 20, 2006 (2006-06-20) | Katey Sagal, David Milch, Arturo Gatti | N/A |
| 307 | June 21, 2006 (2006-06-21) | Stanley Tucci, Cat Deeley | Van Hunt |
| 308 | June 22, 2006 (2006-06-22) | Jack Black, James Marsden | Sonya Kitchell |
| 309 | June 23, 2006 (2006-06-23) | Tyrese Gibson, Def Leppard, Paul Morrissey | N/A |
| 310 | June 26, 2006 (2006-06-26) | Regis Philbin, John Landis | Snoop Dogg |
| 311 | June 27, 2006 (2006-06-27) | Henry Winkler, Judy Greer, Michael Young | N/A |
| 312 | June 28, 2006 (2006-06-28) | Dave Foley, Amy Sedaris | UB40 |
| 313 | June 29, 2006 (2006-06-29) | Tim Robbins | T.I. |
| 314 | June 30, 2006 (2006-06-30) | Jesse James, Paul Dinello | She Wants Revenge |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 315 | July 5, 2006 (2006-07-05) | Laurence Fishburne, Illeana Douglas | Jack's Mannequin |
| 316 | July 6, 2006 (2006-07-06) | Tom Lennon | Jewel |
| 317 | July 7, 2006 (2006-07-07) | Donal Logue | Ne-Yo |
| 318 | July 10, 2006 (2006-07-10) | Toni Collette, Lawrence Block, Joe Theismann | N/A |
| 319 | July 11, 2006 (2006-07-11) | Julie Chen, Denise Mina | Echo & the Bunnymen |
| 320 | July 12, 2006 (2006-07-12) | Danny Bonaduce, Cote De Pablo, Bill McArthur | N/A |
| 321 | July 13, 2006 (2006-07-13) | Joe Mantegna | Brooks & Dunn |
| 322 | July 14, 2006 (2006-07-14) | Nick Cannon, Kyle Dunnigan | Family Force 5 |
| 323 | July 24, 2006 (2006-07-24) | Eddie Izzard, Greg Warren | The Buzzcocks |
| 324 | July 25, 2006 (2006-07-25) | Kevin Smith, Carrie Ann Inaba | Seether |
| 325 | July 26, 2006 (2006-07-26) | Cuba Gooding Jr., Jay Larson | Jurassic 5 |
| 326 | July 27, 2006 (2006-07-27) | Greg Kinnear, Hugh Hefner, Sammy Hagar | N/A |
| 327 | July 28, 2006 (2006-07-28) | Kyra Sedgwick, Keith Olbermann | N/A |
| 328 | July 31, 2006 (2006-07-31) | Andie MacDowell | Cirque du Soleil's KA |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 329 | August 1, 2006 (2006-08-01) | Bonnie Raitt, Travis Pastrana | Randy Kagan |
| 330 | August 2, 2006 (2006-08-02) | Drew Pinsky, Carnie Wilson | Tally Hall |
| 331 | August 3, 2006 (2006-08-03) | Jaime Pressly, Robbie Coltrane | Michael Franti & Spearhead |
| 332 | August 4, 2006 (2006-08-04) | Carlos Mencia | Natasha Bedingfield |
| 333 | August 7, 2006 (2006-08-07) | Steve Carell | The Subways |
| 334 | August 8, 2006 (2006-08-08) | Aaron Eckhart, Cheyenne Kimball, Fran Solomita | N/A |
| 335 | August 9, 2006 (2006-08-09) | Tim Olyphant, Lindsay Sloane | The Editors |
| 336 | August 10, 2006 (2006-08-10) | Christina Milian, Tim Olyphant, Brian Malow | N/A |
| 337 | August 11, 2006 (2006-08-11) | Michael Clarke Duncan, Laura Kightlinger | Rob Zombie |
| 338 | August 14, 2006 (2006-08-14) | Chi McBride, Lili Taylor | Nick Lachey |
| 339 | August 15, 2006 (2006-08-15) | Matt Dillon, Padma Lakshmi | Paula DeAnda, Baby Bash |
| 340 | August 16, 2006 (2006-08-16) | Alice Cooper, Penelope Ann Miller | N/A |
| 341 | August 17, 2006 (2006-08-17) | Jane Kaczmarek, Esai Morales, Larke Miller | N/A |
| 342 | August 21, 2006 (2006-08-21) | Shannen Doherty, Eddie Kaye Thomas | E-40 T-Pain |
| 343 | August 22, 2006 (2006-08-22) | Fred Willard, Rachel Blanchard, Stephen J. Cannell | N/A |
| 344 | August 23, 2006 (2006-08-23) | Amy Smart, Trace Adkins | N/A |
| 345 | August 24, 2006 (2006-08-24) | Denis Leary, Lewis Dix | Matt Goss |
| 346 | August 25, 2006 (2006-08-25) | André Benjamin, David Boreanaz | Mellowdrone |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 347 | September 11, 2006 (2006-09-11) | Aaron Brown, Ralph Geidel | Paolo Nutini |
| 348 | September 12, 2006 (2006-09-12) | Michael Rapaport, Joely Fisher | N/A |
| 349 | September 13, 2006 (2006-09-13) | Virginia Madsen, Jason Ritter | Matt Baetz |
| 350 | September 14, 2006 (2006-09-14) | Gary Sinise, Whitley Strieber | Chris Isaak |
| 351 | September 15, 2006 (2006-09-15) | Mia Kirshner | Method Man |
| 352 | September 18, 2006 (2006-09-18) | Edward Norton, Ethan Suplee | LeToya |
| 353 | September 19, 2006 (2006-09-19) | Skeet Ulrich, Nora Ephron | Rodney Atkins |
| 354 | September 20, 2006 (2006-09-20) | James Woods, George Eads | Heartland |
| 355 | September 21, 2006 (2006-09-21) | Chazz Palminteri, Kerry Washington | French Kiss |
| 356 | September 22, 2006 (2006-09-22) | Bradley Whitford, Trudie Styler, Larry Johnson | Sam Roberts |
| 357 | September 25, 2006 (2006-09-25) | Lauren Graham, Nick Griffin | Joan Jett |
| 358 | September 26, 2006 (2006-09-26) | Marie Osmond, Jacinda Barrett, Mitch Albom | N/A |
| 359 | September 27, 2006 (2006-09-27) | Forest Whitaker, Julie Walters, Shang Forbes | N/A |
| 360 | September 28, 2006 (2006-09-28) | Billy Connolly, Michael Ian Black | M. Ward |
| 361 | September 29, 2006 (2006-09-29) | Billy Bob Thornton, Duane Martin | Starsailor |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 362 | October 2, 2006 (2006-10-02) | Jon Favreau, Kristen Bell | Amos Lee |
| 363 | October 3, 2006 (2006-10-03) | Tim Daly, David Cross | Diana Krall |
| 364 | October 4, 2006 (2006-10-04) | Busta Rhymes, Connie Britton | N/A |
| 365 | October 5, 2006 (2006-10-05) | Brooke Shields, Michael Ian Black | Billy Bragg |
| 366 | October 6, 2006 (2006-10-06) | Howie Mandel, Andy Summers | Rodrigo y Gabriela |
| 367 | October 9, 2006 (2006-10-09) | Emmitt Smith, Kristin Chenoweth | N/A |
| 368 | October 10, 2006 (2006-10-10) | Laura Linney, Jordanna Brester | Say Anything |
| 369 | October 11, 2006 (2006-10-11) | David Arquette | Monica |
| 370 | October 12, 2006 (2006-10-12) | Jennifer Beals, Michael Sheen | Chingy |
| 371 | October 13, 2006 (2006-10-13) | Michael Caine | Mario Vasquez |
| 372 | October 23, 2006 (2006-10-23) | Maria Bello, Derek Luke | Robin Thicke |
| 373 | October 24, 2006 (2006-10-24) | Alan Arkin, Paul Haggis | Jimmy Pardo |
| 374 | October 25, 2006 (2006-10-25) | Ron Rifkin, Kevin Nealon | Corinne Bailey Rae |
| 375 | October 26, 2006 (2006-10-26) | Brooke Hogan, Eva La Rue, Jason Schwartzman | N/A |
| 376 | October 27, 2006 (2006-10-27) | Danny Bonaduce, Gene Pompa | Mew |
| 377 | October 30, 2006 (2006-10-30) | Kim Raver, Bob Saget | Deana Carter & Heart |
| 378 | October 31, 2006 (2006-10-31) | Carrie Fisher, Todd Oliver | Alice Cooper |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 379 | November 1, 2006 (2006-11-01) | Barry Pepper, Amy Sedaris | Carlos Alazraqui |
| 380 | November 2, 2006 (2006-11-02) | Tim Robbins, Jamie Lidell | N/A |
| 381 | November 3, 2006 (2006-11-03) | Alec Baldwin, Barry Manilow | N/A |
| 382 | November 6, 2006 (2006-11-06) | Val Kilmer, Rebecca Gayheart | Paolo Nutini |
| 383 | November 8, 2006 (2006-11-08) | Merv Griffin, Marshall Faulk | Carrot Top |
| 384 | November 9, 2006 (2006-11-09) | Emma Thompson, Eamonn Walker | Joseph Arthur |
| 385 | November 10, 2006 (2006-11-10) | Ashley Judd, Seth MacFarlane | Pet Shop Boys |
| 386 | November 13, 2006 (2006-11-13) | Hugh Laurie, Spike Feresten | OK Go |
| 387 | November 14, 2006 (2006-11-14) | Steven Weber, Emily Deschanel, Phil Rosenthal | N/A |
| 388 | November 15, 2006 (2006-11-15) | Anne Heche, Rain Pryor | Jeff Caldwell |
| 389 | November 16, 2006 (2006-11-16) | Maura Tierney, Scott Turow | Lindsay Buckingham |
| 390 | November 17, 2006 (2006-11-17) | Ice-T, Henry Cho | N/A |
| 391 | November 20, 2006 (2006-11-20) | Christian Slater, Sue Johanson | Driveblind |
| 392 | November 21, 2006 (2006-11-21) | Emilio Estevez, Eva Pigford | Jim Short |
| 393 | November 22, 2006 (2006-11-22) | Fred Willard, Ashley Scott | Gabriel Iglesias |
| 394 | November 23, 2006 (2006-11-23) | Felicity Huffman, Dax Shepard | Akon |
| 395 | November 27, 2006 (2006-11-27) | William Shatner, Mike Luckovich | Driveblind |
| 396 | November 28, 2006 (2006-11-28) | William H. Macy, Jeri Ryan, Isabel Allende | N/A |
| 397 | November 29, 2006 (2006-11-29) | Anthony LaPaglia, Carl Edwards | Sparta |
| 398 | November 30, 2006 (2006-11-30) | John Waters, Alex Borstein | Plain White T's |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 399 | December 1, 2006 (2006-12-01) | Kevin Smith, Suzy Nakamura | Joseph Arthur |
| 400 | December 4, 2006 (2006-12-04) | Betty White, Twiggy | Sam Moore & Travis Tritt |
| 401 | December 6, 2006 (2006-12-06) | John Stamos, Sean Maguire | Ziggy Marley |
| 402 | December 7, 2006 (2006-12-07) | Chris Kattan, Chiwetel Ejiofor | Ciara |
| 403 | December 8, 2006 (2006-12-08) | John Novasad | Tyrese |
| 404 | December 11, 2006 (2006-12-11) | Ted Danson, Julia Sweeney | Akon |
| 405 | December 12, 2006 (2006-12-12) | Camryn Manheim, Stephen Fry | N/A |
| 406 | December 13, 2006 (2006-12-13) | Rob Morrow, Lucy Lawless | Jet |
| 407 | December 14, 2006 (2006-12-14) | Pat Croce | Jewel |
| 408 | December 15, 2006 (2006-12-15) | Michael Rapaport, Tom Kenny | N/A |
| 409 | December 18, 2006 (2006-12-18) | Edward Norton, Jenna Fischer | N/A |
| 410 | December 19, 2006 (2006-12-19) | Laura Dern, Ming Tsai, Danny Elfman | N/A |
| 411 | December 20, 2006 (2006-12-20) | Paula Poundstone | Xzibit |
| 412 | December 21, 2006 (2006-12-21) | Samuel L. Jackson, Avi Liberman | Hinder |
| 413 | December 22, 2006 (2006-12-22) | Dominic Monaghan, Anthony Mackie | Twisted Sister |

## 2007
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 414 | January 2, 2007 (2007-01-02) | James Denton, Dan Gabriel, Julie Gribble | N/A |
| 415 | January 3, 2007 (2007-01-03) | Kate Walsh, Clark Gregg, Skyler Stone | N/A |
| 416 | January 4, 2007 (2007-01-04) | Carl Reiner, Tracee Ellis Ross, Max Brooks | N/A |
| 417 | January 5, 2007 (2007-01-05) | Neil Patrick Harris, Sherri Shepherd | Hellogoodbye |
| 418 | January 8, 2007 (2007-01-08) | Mario Lopez, Shawn Colvin | Ne-Yo |
| 419 | January 9, 2007 (2007-01-09) | Jonathan Silverman, Antonio Gates | Greg Proops |
| 420 | January 10, 2007 (2007-01-10) | LL Cool J, Masi Oka | Chris Daughtry |
| 422 | January 11, 2007 (2007-01-11) | Emily Watson, Ed Begley Jr., Cash Levy | N/A |
| 423 | January 12, 2007 (2007-01-12) | Emily Blunt, Louis C.K. | Lady Sovereign |
| 424 | January 15, 2007 (2007-01-15) | Teutul Sr. & Jr., Kelly Hu, Greg Owen | N/A |
| 425 | January 16, 2007 (2007-01-16) | Helen Mirren | Steve Trevino |
| 426 | January 17, 2007 (2007-01-17) | Juliette Lewis, Aaron Lewis | Common |
| 427 | January 18, 2007 (2007-01-18) | Chevy Chase, Hannah Storm | Montgomery |
| 428 | January 19, 2007 (2007-01-19) | Tony Gonzalez | Fantasia |
| 429 | January 29, 2007 (2007-01-29) | Dylan McDermott, Connie Nielsen | Billy Bragg |
| 430 | January 30, 2007 (2007-01-30) | Julie Bowen, Terry Crews, Michael Meehan | N/A |
| 431 | January 31, 2007 (2007-01-31) | Chad Lowe, RZA | N/A |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 432 | February 1, 2007 (2007-02-01) | Henry Winkler, Zoe Saldana | Jet |
| 433 | February 2, 2007 (2007-02-02) | Jerry Springer, Robert Dubac | Aaron Lewis |
| TBA | February 4, 2007 (2007-02-04) | Billy Bob Thornton | Hank Williams Jr. and Lynrd Skynrd performs Gimme Three Steps; Phi Beta Signma Step Team |
| Super Bowl Special from Colony Theatre in Miami Beach. Ferguson chats strategy with Mike Ditka, tosses the football with Dan Marino, gets tattooed by Ami James at Miami Ink, speaks with Hannah Storm and Cato June from Dolphin Stadium and lunches with Gloria Estefan. IHOP skit with a plethora of "stars" all played by Ferguson. Tim Meadows and Bradley Laise also appear in skits. ||||
| 434 | February 5, 2007 (2007-02-05) | Danny Bonaduce, Tom Lennon | Ben Garant |
| 435 | February 6, 2007 (2007-02-06) | Mena Suvari, Lawrence Block | Naked Trucker |
| 436 | February 7, 2007 (2007-02-07) | Bob Saget, Kaylee Defer | Jonny Lang |
| 437 | February 8, 2007 (2007-02-08) | Thandie Newton | The Game |
| 438 | February 9, 2007 (2007-02-09) | Eddie Griffin, Mat Kearney | Steve Mazan |
| 439 | February 12, 2007 (2007-02-12) | Peter O'Toole, Joely Fisher | Dierks Bentley & The Grascals |
| 440 | February 13, 2007 (2007-02-13) | Aisha Tyler, Harry Shearer, Tyler Williamson | N/A |
| 441 | February 14, 2007 (2007-02-14) | David Hasselhoff, Richard Wiese | K.T. Tunstall |
| 442 | February 15, 2007 (2007-02-15) | Jennifer Love Hewitt, John Cena | Three Days Grace |
| 443 | February 16, 2007 (2007-02-16) | Kiefer Sutherland, Sam Tripoli | Rich Boy |
| 444 | February 19, 2007 (2007-02-19) | Virginia Madsen, David Steinberg | Unwritten Law |
| 445 | February 20, 2007 (2007-02-20) | Patricia Heaton, Parminder Nagra | N/A |
| 446 | February 21, 2007 (2007-02-21) | Danny Bonaduce, Ioan Gruffudd | Gordie Brown |
| 447 | February 22, 2007 (2007-02-22) | Mark Ruffalo, Wolfgang Puck | Tom Lennon & Ben Garant |
| 448 | February 23, 2007 (2007-02-23) | Jennifer Tilly, Ami James | Rodney Atkins |
| 449 | February 26, 2007 (2007-02-26) | Regis Philbin, James McAvoy | Red Jumpsuit Apparatus |
| 450 | February 27, 2007 (2007-02-27) | Jill Hennessy, Oliver Hudson, Jim McDonald | N/A |
| 451 | February 28, 2007 (2007-02-28) | Billy Connolly, Tricia Helfer | Blake Shelton |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 452 | March 1, 2007 (2007-03-01) | Jennifer Tilly, Seth MacFarlane | The Cat Empire |
| 453 | March 2, 2007 (2007-03-02) | John Mellencamp, Oscar De La Hoya | N/A |
| 454 | March 5, 2007 (2007-03-05) | Jennifer Hudson, Gerard Butler | Anberlin |
| 455 | March 6, 2007 (2007-03-06) | Poppy Montgomery, Jeremy Roenick, Paul Morrissey | N/A |
| 456 | March 7, 2007 (2007-03-07) | Andy Garcia, Rob Corddry | N/A |
| 457 | March 8, 2007 (2007-03-08) | Bill Maher, Jacinda Barrett | Razorlight |
| 458 | March 9, 2007 (2007-03-09) | Kerry Washington, Jeff Applebaum | Aaron Lewis |
| 459 | March 19, 2007 (2007-03-19) | Merv Griffin, Nia Long | John Mellencamp |
| 460 | March 20, 2007 (2007-03-20) | Cuba Gooding Jr., Joely Richardson | Andy Vastola |
| 461 | March 21, 2007 (2007-03-21) | Tom Arnold, Drake Witham | Hinder |
| 462 | March 26, 2007 (2007-03-26) | Joss Stone, Rainn Wilson | Joss Stone |
| 463 | March 27, 2007 (2007-03-27) | Randy Jackson, Piper Perabo | Roy Wood Jr. |
| 464 | March 28, 2007 (2007-03-28) | Sigourney Weaver, Kal Penn | The Ataris |
| 465 | March 29, 2007 (2007-03-29) | Jeff Goldblum | Papa Roach |
| 466 | March 30, 2007 (2007-03-30) | Chandra Wilson, Bobby Miyamoto | Bone Thugs N' Harmony |

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 467 | April 2, 2007 (2007-04-02) | Josh Brolin, Jason Segel, Matt Knudsen | N/A |
| 468 | April 3, 2007 (2007-04-03) | Rose McGowan, Wolfgang Puck | N/A |
| 469 | April 4, 2007 (2007-04-04) | Robert Rodriguez, John C. McGinley | N/A |
| 470 | April 5, 2007 (2007-04-05) | Sydney Tamiia Poitier, Ice Cube | Omarion |
| 471 | April 6, 2007 (2007-04-06) | Carla Gugino, Randy Couture | Redman |
| 472 | April 9, 2007 (2007-04-09) | Kurt Russell, Barry Sonnenfeld | Paul Wall |
| 473 | April 10, 2007 (2007-04-10) | Quentin Tarantino, Laura Prepon | N/A |
| 474 | April 11, 2007 (2007-04-11) | Jeff Probst, Amy Yasbeck | Greg Warren |
| 475 | April 12, 2007 (2007-04-12) | David Duchovny, Nia Long | K-os |
| 476 | April 13, 2007 (2007-04-13) | Julia Louis-Dreyfus, Rodney Carrington | Cold War Kids |
| 477 | April 23, 2007 (2007-04-23) | Mary Hart, Brady Quinn | The Exies |
| 478 | April 24, 2007 (2007-04-24) | Paula Abdul, Vinnie Jones | Billy D. Washington |
| 479 | April 25, 2007 (2007-04-25) | Jerry Springer, Mario | Simply Red |
| 480 | April 26, 2007 (2007-04-26) | Jenny McCarthy, Frank McCourt | Mo Mandel |
| 481 | April 27, 2007 (2007-04-27) | Jon Cryer, Boyd Matson | Good Charlotte |
| 482 | April 30, 2007 (2007-04-30) | Frank Caliendo, Samantha Mathis | The Noisettes |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 483 | May 1, 2007 (2007-05-01) | Tim Daly, Charlie Viracola | Joe |
| 484 | May 2, 2007 (2007-05-02) | Eric Bana, Julia Sweeney | Fountains of Wayne |
| 485 | May 3, 2007 (2007-05-03) | Alice Cooper, Michael Rosenbaum | Gary Gulman |
| 486 | May 4, 2007 (2007-05-04) | Molly Shannon, Duane Martin | Ozomatli |
| 487 | May 7, 2007 (2007-05-07) | Sophia Bush | Ne-Yo |
| 488 | May 8, 2007 (2007-05-08) | Floyd Mayweather, Julianne Nicholson | Lynne Koplitz |
| 489 | May 9, 2007 (2007-05-09) | Steven Wright, Carrie Ann Inaba | Dinosaur Jr. |
| 490 | May 10, 2007 (2007-05-10) | Garry Shandling, Nathan Fillion | Craig Morgan |
| 491 | May 11, 2007 (2007-05-11) | Larry the Cable Guy, Maureen McCormick | Montgomery Gentry |
| 492 | May 14, 2007 (2007-05-14) | Carrot Top, Miranda Lambert | N/A |
| 493 | May 15, 2007 (2007-05-15) | Roseanne Barr, Malachy McCourt | N/A |
| 494 | May 16, 2007 (2007-05-16) | Bob Barker, Elizabeth Banks | Modest Mouse |
| 495 | May 17, 2007 (2007-05-17) | Phil McGraw | Tori Amos |
| 496 | May 18, 2007 (2007-05-18) | Gina Gershon, Dan Naturman | The Exies |
| 497 | May 21, 2007 (2007-05-21) | Lance Burton, Matt Serra | Chantal Kreviazuk |
| 498 | May 22, 2007 (2007-05-22) | Carrie Fisher, Naomie Harris, Nathan Gibson | N/A |
| 499 | May 23, 2007 (2007-05-23) | Jason Randal, Cat Deeley | Albert Hammond, Jr. |
| 500 | May 24, 2007 (2007-05-24) | Chi McBride, Rick Thomas | Patti Smith |
| 501 | May 25, 2007 (2007-05-25) | Bob Saget, Guy Torry | Jade |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 502 | June 4, 2007 (2007-06-04) | Dennis Hopper, Eddie Pence | Darryl Worley |
| 503 | June 5, 2007 (2007-06-05) | Rosie Perez, David Milch | Patti Smith |
| 504 | June 6, 2007 (2007-06-06) | Carl Reiner, Jonah Hill | Bright Eyes |
| 505 | June 7, 2007 (2007-06-07) | Don Cheadle, Bret Michaels | Poison |
| 506 | June 8, 2007 (2007-06-08) | Jon Heder, Criss Angel | N/A |
| 507 | June 11, 2007 (2007-06-11) | Don Rickles, Ali Wentworth | Marty Stuart |
| 508 | June 12, 2007 (2007-06-12) | Parker Posey, Ian Hunter | N/A |
| 509 | June 13, 2007 (2007-06-13) | Eric Idle, S., Epatha Merkerson | Guy Torry |
| 510 | June 14, 2007 (2007-06-14) | Jeff Bridges, Carrie-Anne Moss | Mute Math |
| 511 | June 15, 2007 (2007-06-15) | Seth Green, Bob Barker | Henry Cho |
| 512 | June 18, 2007 (2007-06-18) | Avril Lavigne, Ioan Gruffudd | Avril Lavigne |
| 513 | June 19, 2007 (2007-06-19) | Drew Pinsky | Enrique Iglesias |
| 514 | June 20, 2007 (2007-06-20) | Mo'Nique | Big and Rich |
| 515 | June 21, 2007 (2007-06-21) | Ben Kingsley, Mary McCormack | Jesse Malin |
| 516 | June 22, 2007 (2007-06-22) | Eddie Izzard, John Roy | The Goo Goo Dolls |
| 517 | June 25, 2007 (2007-06-25) | Wanda Sykes, Tim Spall | Bobby Valentino |
| 518 | June 26, 2007 (2007-06-26) | Janeane Garofalo, Tina Brown | Bob Marley |
| 519 | June 27, 2007 (2007-06-27) | Mandy Moore, David Steinberg | N/A |
| 520 | June 28, 2007 (2007-06-28) | Wayne Brady, Mary Elizabeth Winstead | Ben Kweller |
| 521 | June 29, 2007 (2007-06-29) | Chris Isaak, Cory Kahaney | N/A |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 522 | July 2, 2007 (2007-07-02) | Dr. Kevin Fitzgerald | Sinéad O'Connor |
| 523 | July 3, 2007 (2007-07-03) | Kristen Bell, Wolfgang Puck | Big and Rich |
| 524 | July 5, 2007 (2007-07-05) | Brenda Blethyn, Mike Rowe | Army of Me |
| 525 | July 6, 2007 (2007-07-06) | Amy Sedaris, Jackie Collins | Breaking Benjamin |
| 526 | July 9, 2007 (2007-07-09) | Kathy Griffin, Ken Bruen | Marty Stuart |
| 527 | July 10, 2007 (2007-07-10) | Cedric the Entertainer, Kara Cooney | Jeff Keith |
| 528 | July 11, 2007 (2007-07-11) | Julie Chen, James Marsden | Sara Bareilles |
| 529 | July 12, 2007 (2007-07-12) | Ted Danson, Maggie Q | Silverchair |
| 530 | July 13, 2007 (2007-07-13) | Rupert Grint | Dr. Dog |
| 531 | July 23, 2007 (2007-07-23) | Glenn Close, Jeffrey Ross | Lily Allen |
| 532 | July 24, 2007 (2007-07-24) | Julia Stiles, Carl Bernstein | N/A |
| 533 | July 25, 2007 (2007-07-25) | Jason Priestley, Sherri Shepherd | Chris Reid |
| 534 | July 26, 2007 (2007-07-26) | Aaron Eckhart | Hanson |
| 535 | July 27, 2007 (2007-07-27) | James Denton, Amber Stevens | The Cribs |
| 536 | July 30, 2007 (2007-07-30) | Drew Carey, Megalyn Echikunwoke | N/A |
| 537 | July 31, 2007 (2007-07-31) | Jon Voight, Alicia Coppola | Will Marfori |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 538 | August 1, 2007 (2007-08-01) | Miss Piggy, Jonathan Silverman | Glen Hansard, Markéta Irglová |
| 539 | August 2, 2007 (2007-08-02) | Julie Delpy, Alfred Molina | N/A |
| 540 | August 3, 2007 (2007-08-03) | Pamela Anderson, Nellie McKay | Hans Klok, Avi Liberman |
| 541 | August 6, 2007 (2007-08-06) | Kyra Sedgwick, Paula Poundstone | Emerson Drive |
| 542 | August 7, 2007 (2007-08-07) | Ben Stein, Megyn Price | Rodney Laney |
| 543 | August 8, 2007 (2007-08-08) | Michelle Pfeiffer, Rachel Nichols | Kat DeLuna |
| 544 | August 10, 2007 (2007-08-10) | Cuba Gooding Jr., Cash Levy | Grace Potter & the Nocturnals |
| 545 | August 13, 2007 (2007-08-13) | Tori Spelling | Brother Ali |
| 546 | August 14, 2007 (2007-08-14) | Jonah Hill, Natascha McElhone | N/A |
| 547 | August 15, 2007 (2007-08-15) | Aishwarya Rai, Dom Irrera | Lifehouse |
| 548 | August 16, 2007 (2007-08-16) | Masi Oka | Emily Fox, Emerson Hart |
| 549 | August 17, 2007 (2007-08-17) | Aisha Tyler, Dwayne Perkins | Augie March |
| 550 | August 20, 2007 (2007-08-20) | Tony Danza, Rose Byrne | N/A |
| 551 | August 21, 2007 (2007-08-21) | Nick Cannon, Alan Bean | Jeremy Fisher |
| 552 | August 22, 2007 (2007-08-22) | Tom Lennon, Elizabeth Perkins | Wendy Kamenoff |
| 553 | August 23, 2007 (2007-08-23) | Samuel L. Jackson | The Cliks |
| 554 | August 24, 2007 (2007-08-24) | Holly Hunter, Adam Goldberg | Ferraby Lionheart |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 554 | September 10, 2007 (2007-09-10) | Frank Caliendo, Sherman Alexie | Clay Walker |
| 555 | September 11, 2007 (2007-09-11) | Gavin de Becker, Dwight Yoakam | N/A |
| 556 | September 12, 2007 (2007-09-12) | Julie Chen, Dario Franchitti | Matt Baetz |
| 557 | September 13, 2007 (2007-09-13) | Jason Alexander, Barbara Morgan, Scott Kelly | Wendy Kamenoff |
| 558 | September 14, 2007 (2007-09-14) | Eric Idle, Les Stroud | Finger Eleven |
| 559 | September 17, 2007 (2007-09-17) | Alan Alda, Alex O'Loughlin | N/A |
| 560 | September 18, 2007 (2007-09-18) | Jeff Goldblum, Paul Haggis, Mandy Moore | N/A |
| 561 | September 19, 2007 (2007-09-19) | Phil McGraw, Kaley Cuoco | Bob Dubac |
| 562 | September 20, 2007 (2007-09-20) | James Woods, Ben Lee | N/A |
| 563 | September 21, 2007 (2007-09-21) | Terrence Howard, Jennifer Westfeldt | Zap Mama |
| 564 | September 24, 2007 (2007-09-24) | 50 Cent, Emily Deschanel | N/A |
| 565 | September 25, 2007 (2007-09-25) | D.L. Hughley, Kaitlin Olson, Hannibal Buress | N/A |
| 566 | September 26, 2007 (2007-09-26) | Marg Helgenberger, Seth MacFarlane | The National |
| 567 | September 27, 2007 (2007-09-27) | Jennifer Love Hewitt, Oliver Hudson | Cary Brothers |
| 568 | September 28, 2007 (2007-09-28) | Greg Kinnear, Paul Morrissey | Raul Midon |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 569 | October 1, 2007 (2007-10-01) | Juliette Lewis, David Boreanaz | N/A |
| 570 | October 2, 2007 (2007-10-02) | Chi McBride, Teri Polo | Steve Bertrand |
| 571 | October 3, 2007 (2007-10-03) | Kevin Smith, Tasha Smith | J.L. Cauvin |
| 572 | October 4, 2007 (2007-10-04) | Anjelica Huston, Pat Monahan | Cathy Ladman |
| 573 | October 5, 2007 (2007-10-05) | Josh Duhamel, Radha Mitchell | Diana Krall |
| 574 | October 8, 2007 (2007-10-08) | Jimmy Smits, Michelle Monaghan | Shout Out Louds |
| 575 | October 9, 2007 (2007-10-09) | Tim Daly, Nia Long | Ron Pearson |
| 576 | October 10, 2007 (2007-10-10) | Fred Willard, Saffron Burrows | Modest Mouse |
| 577 | October 11, 2007 (2007-10-11) | Tom Arnold, Tori Amos | N/A |
| 577 | October 12, 2007 (2007-10-12) | Lt. Col Kevin Robbins | N/A |
| 578 | October 15, 2007 (2007-10-15) | Michael Caine | Lizzy Cooperman |
| 579 | October 16, 2007 (2007-10-16) | Vicente Fox, Leslie Bibb | Ron Pearson |
| 580 | October 17, 2007 (2007-10-17) | Ian McKellen, Jena Malone | Avril Lavigne |
| 581 | October 18, 2007 (2007-10-18) | John Larroquette | They Might Be Giants |
| 582 | October 19, 2007 (2007-10-19) | Kenneth Branagh, Todd Sawyer | N/A |
| 583 | October 29, 2007 (2007-10-29) | Kristin Chenoweth, Clive Barker | James Jonah |
| 584 | October 30, 2007 (2007-10-30) | Steve Carell | Good Charlotte |
| 585 | October 31, 2007 (2007-10-31) | John Lydon, Steve Jones, Joe Theisman | The Sex Pistols |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 586 | November 1, 2007 (2007-11-01) | Anthony Hopkins, Yvonne Strahovski | N/A |
| 587 | November 2, 2007 (2007-11-02) | Seth Green, Dwight Yoakam | N/A |
There were no other episodes produced in November as well as all of December due to the 2007–08 Writers Guild of America strike.

## 2008
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 589 | January 2, 2008 (2008-01-02) | None | N/A |
| No guests. Although the Writers Guild of America was on strike, David Letterman's Worldwide Pants, Inc., which produced The Late Late Show and owned its timeslot, negotiated with the WGA and met their demands. ||||
| 590 | January 3, 2008 (2008-01-03) | Dominic Monaghan, Jason Randal | N/A |
| 591 | January 4, 2008 (2008-01-04) | Leonard Nimoy, Lyle Lovett | N/A |
| 592 | January 7, 2008 (2008-01-07) | RZA, Greg Proops | N/A |
| 593 | January 8, 2008 (2008-01-08) | Marion Cotillard, Kevin Fitzgerald | Rogue Wave |
| 594 | January 9, 2008 (2008-01-09) | Emile Hirsch, Wolfgang Puck | N/A |
| 595 | January 10, 2008 (2008-01-10) | Val Kilmer, Michael Gates Gill | Ian Hunter |
| 596 | January 11, 2008 (2008-01-11) | Alec Baldwin, Lena Headey | Spoon |
| During Baldwin's interview, Ferguson notes the obvious and oversimplified nature of his notecard, and tears it up. This tearing of notecards becomes a permanent hallmark of Ferguson's interviews, signaling his intent to have a real, unscripted conversation with guests. ||||
| 597 | January 14, 2008 (2008-01-14) | Ben Kingsley, Laura Prepon | Lupe Fiasco |
| 598 | January 15, 2008 (2008-01-15) | Drew Carey, Seth Gabel | Kate Nash |
| 599 | January 16, 2008 (2008-01-16) | James McAvoy, Jon Cryer | Blake Lewis |
| 600 | January 17, 2008 (2008-01-17) | Trace Adkins, Julie Benz | N/A |
| 601 | January 18, 2008 (2008-01-18) | Ted Danson, Ali Wentworth | N/A |
| 602 | January 21, 2008 (2008-01-21) | Sylvester Stallone, Steve Wiebe | N/A |
| 603 | January 22, 2008 (2008-01-22) | Tony Shalhoub, Becki Newton | Dean Edwards |
| 604 | January 23, 2008 (2008-01-23) | Carmen Electra, Justin Bartha | Comedienne Margaret Cho |
| 605 | January 24, 2008 (2008-01-24) | Ringo Starr | Ringo Starr & His All Starr Band |
| 606 | January 25, 2008 (2008-01-25) | Diane Lane, James Johann | Ayọ |
| 607 | January 28, 2008 (2008-01-28) | Denis Leary | Deana Carter |
| 608 | January 29, 2008 (2008-01-29) | Raquel Welch | Lyle Lovett |
| 609 | January 30, 2008 (2008-01-30) | Antonio Gates, Adam Arkin | Ryan Sickler |
| 610 | January 31, 2008 (2008-01-31) | Julia Louis-Dreyfus, Lindsay Sloane | N/A |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 611 | February 1, 2008 (2008-02-01) | Eva Longoria Parker, Allen Covert | Al Madrigal |
| 612 | February 4, 2008 (2008-02-04) | Kristen Bell | Wicked Tinkers |
| Video of Ferguson being sworn in as a US citizen. Monologue includes a description of his first solo flight, and announcement of his being chosen to host the 2008 White House Correspondents' Dinner. ||||
| 613 | February 5, 2008 (2008-02-05) | Amy Ryan, Terry Crews | Sebastian Maniscalco |
| 614 | February 6, 2008 (2008-02-06) | Bradley Whitford, Lake Bell, Cynthia Littleton | N/A |
| 615 | February 7, 2008 (2008-02-07) | Jon Favreau, Alicia Coppola | Shelby Lynne |
| 616 | February 8, 2008 (2008-02-08) | Jessica Alba, Dierks Bentley | Mo'Nique |
| 617 | February 11, 2008 (2008-02-11) | Julie Chen, Natasha Bedingfield | N/A |
| 618 | February 12, 2008 (2008-02-12) | Susan Sarandon, Bonnie Somerville | N/A |
| 619 | February 13, 2008 (2008-02-13) | Michael Clarke Duncan, Jan Davidson | North Mississippi Allstars |
| 620 | February 14, 2008 (2008-02-14) | Evangeline Lilly, Adam Goldberg | Bebel Gilberto |
| 621 | February 15, 2008 (2008-02-15) | Jeffrey Tambor, Ivana Miličević, Bobby Miyamoto | N/A |
| 622 | February 18, 2008 (2008-02-18) | Alice Cooper, Angela Kinsey | Wyclef Jean |
| 623 | February 19, 2008 (2008-02-19) | Andre Benjamin, Craig Bierko | Melinda Hill |
| 624 | February 20, 2008 (2008-02-20) | Tom Selleck, Dario Franchitti | Ziggy Marley |
| 625 | February 21, 2008 (2008-02-21) | Don Rickles, Joe Mantegna | N/A |
| 626 | February 22, 2008 (2008-02-22) | Fred Willard, Rachel Bilson | N/A |
| 627 | February 25, 2008 (2008-02-25) | Jennifer Beals, Carrie Ann Inaba | Little Big Town |
| 628 | February 26, 2008 (2008-02-26) | Regis Philbin | Alice Smith |
| 629 | February 27, 2008 (2008-02-27) | Eric Bana, Patricia Clarkson | Barry Manilow |
| 630 | February 28, 2008 (2008-02-28) | Natasha Henstridge, Carl Bernstein | Steve Mazan |
| 631 | February 29, 2008 (2008-02-29) | Dweezil Zappa, Jason Randal; Josh Robert Thompson appears as Arnold Schwarzenegger | Coolio |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 632 | March 3, 2008 (2008-03-03) | Brooke Shields, Ming Tsai | Michelle Biloon |
| 633 | March 4, 2008 (2008-03-04) | Christina Ricci, Dee Dee Myers | Collective Soul |
| 634 | March 5, 2008 (2008-03-05) | Dennis Hopper, Yunjin Kim | Nicole Atkins |
| 635 | March 6, 2008 (2008-03-06) | Wanda Sykes, Saffron Burrows | Grizzly Bear |
| 636 | March 7, 2008 (2008-03-07) | Amy Sedaris, Shanna Moakler | Blake Shelton |
| 637 | March 17, 2008 (2008-03-17) | Ray Romano, Kate Flannery | Jeff Caldwell |
| U2 skit with Ferguson as Bono and Philip McGrade as The Edge ||||
| 638 | March 18, 2008 (2008-03-18) | Kate Beckinsale, Ken Tucker | N/A |
| 639 | March 19, 2008 (2008-03-19) | Parker Posey | Graham Colton performs "Best Days" |
| 640 | March 24, 2008 (2008-03-24) | Laurence Fishburne, Rashida Jones | Joe Devito |
| 641 | March 25, 2008 (2008-03-25) | Thandie Newton, Dom Irrera | Comedian Dom Irrera |
| Invisible sidekick Davis assists Ferguson with the monologue ||||
| 642 | March 26, 2008 (2008-03-26) | Pamela Anderson, Christian Siriano | N/A |
| Skit: "The Rather Late Programme with Prince Charles" ||||
| 643 | March 31, 2008 (2008-03-31) | Aisha Tyler, Richard Branson | N/A |
| Larry King skit with Ferguson as Larry King and show writer John T. Reynolds as Ferguson First "What Did We Learn On The Show Tonight Craig?" ||||

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 644 | April 1, 2008 (2008-04-01) | Forest Whitaker, Jean-Michel Cousteau | Your Lips Your Lips |
| 645 | April 2, 2008 (2008-04-02) | Marg Helgenberger, Kylie Minogue | Kylie Minogue |
| 646 | April 3, 2008 (2008-04-03) | Jennifer Love Hewitt, Jonny Lee Miller | N/A |
| 647 | April 4, 2008 (2008-04-04) | Jena Malone | Mrs. Hughes |
| 648 | April 7, 2008 (2008-04-07) | Bob Saget, Jennifer Esposito | N/A |
| 649 | April 8, 2008 (2008-04-08) | Anne Heche, Deion Sanders | Comedian Clinton Jackson |
| 650 | April 9, 2008 (2008-04-09) | Roseanne Barr, Kaley Cuoco | Counting Crows perform "You Can't Count on Me" from Saturday Nights and Sunday Mornings |
| U2 skit with Ferguson as Bono, show writer Philip McGrade as the Edge, and show writer John T. Reynolds as Brad Pitt ||||
| 651 | April 10, 2008 (2008-04-10) | Alyson Hannigan, Todd Allen | Del the Funky Homosapien |
| 652 | April 11, 2008 (2008-04-11) | Christina Applegate, Brittany Snow | Gene Pompa |
| 653 | April 14, 2008 (2008-04-14) | John Waters, Daniel Lanois | N/A |
| 654 | April 15, 2008 (2008-04-15) | Julie Andrews, David Krumholtz | N/A |
| 655 | April 16, 2008 (2008-04-16) | Lynn Ferguson, Jackie Chan | Bell X1 |
| 656 | April 17, 2008 (2008-04-17) | Henry Winkler, Cobie Smulders | Liam Finn performs "Second Chance" from I'll Be Lightning |
| Playboy Mansion skit: "Bunny" Ferguson is tries to get in to the party Skit: "The Rather Late Program with Prince Charles" with warm-up comedian Chunky B as the guard ||||
| 657 | April 18, 2008 (2008-04-18) | Kristen Bell, Oliver Hudson | N/A |
| 658 | April 24, 2008 (2008-04-24) | Ben Stein, Alicia Witt | Andrew Norelli |
| 659 | April 25, 2008 (2008-04-25) | Jason Segel, Connie Schultz | N/A |
| 660 | April 28, 2008 (2008-04-28) | Ewan McGregor | Morissey performs "All You Need is Me" |
| Ferguson recounts events at his White House Correspondents' Dinner gig Ewan McGregor joins Ferguson and Philip McGrade for a thoroughly unrehearsed "ESPN UK/Field of Weems" skit. ||||
| 661 | April 29, 2008 (2008-04-29) | Kathy Griffin, Scott Kennedy | Morrissey |
| 662 | April 30, 2008 (2008-04-30) | Jeff Bridges, Sophia Myles | Grand Archives |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 663 | May 1, 2008 (2008-05-01) | Helen Hunt, Sarah Chalke | She & Him |
| 664 | May 2, 2008 (2008-05-02) | Lake Bell, Kal Penn | N/A |
| 665 | May 5, 2008 (2008-05-05) | Hugh Laurie, Michael Starr | N/A |
| 666 | May 6, 2008 (2008-05-06) | John Goodman, Jason Aldean | N/A |
| 667 | May 7, 2008 (2008-05-07) | Felicity Huffman, Mike Doughty | N/A |
| 668 | May 8, 2008 (2008-05-08) | Emily Deschanel, Melvin Lardy | N/A |
| 669 | May 9, 2008 (2008-05-09) | Rachel Griffiths, Christopher Gorham | N/A |
| 670 | May 12, 2008 (2008-05-12) | John Stamos, Judith Smith-Levin | Jaymay |
| 671 | May 13, 2008 (2008-05-13) | John Cusack, Parminder Nagra | N/A |
| 672 | May 14, 2008 (2008-05-14) | Tony Danza, Maura Tierney | N/A |
| 673 | May 15, 2008 (2008-05-15) | David Boreanaz | Carrot Top |
| 674 | May 16, 2008 (2008-05-16) | Reba McEntire, Vinnie Jones | N/A |
| 675 | May 19, 2008 (2008-05-19) | Valerie Bertinelli, Paulina Porizkova | Estelle |
| 676 | May 20, 2008 (2008-05-20) | Clay Aiken, Chelsea Handler | N/A |
| 677 | May 21, 2008 (2008-05-21) | Laura Dern | k.d. lang |
| 678 | May 22, 2008 (2008-05-22) | Steven Wright, Tricia Helfer | N/A |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 679 | June 2, 2008 (2008-06-02) | Julia Louis-Dreyfus | Matt Costa |
| 680 | June 3, 2008 (2008-06-03) | Kristin Davis, Joel McHale | Shooter Jennings |
| 681 | June 4, 2008 (2008-06-04) | Jane Kaczmarek, Greg Proops | N/A |
| 682 | June 5, 2008 (2008-06-05) | Jeff Foxworthy, Chelsea Handler | N/A |
| 683 | June 6, 2008 (2008-06-06) | Poppy Montgomery, Drake Witham | N/A |
| The Late Late Show skit with show writer John T. Reynolds as Ferguson, and Ferguson as Sean Connery. ||||
| 684 | June 9, 2008 (2008-06-09) | Evan Handler, Betty White | MGMT |
| 685 | June 10, 2008 (2008-06-10) | Rachel Dratch, Carl Reiner | Augustana |
| 686 | June 11, 2008 (2008-06-11) | Stockard Channing, Bill Engvall | N/A |
| 687 | June 12, 2008 (2008-06-12) | Jenna Fischer, Wolfgang Puck | N/A |
| Skit with Ferguson as Queen Elizabeth and James Adomian as George W. Bush ||||
| 688 | June 13, 2008 (2008-06-13) | Elizabeth Perkins | Coolio |
| Betty White drops in for a comedy bit "Murder She Wrote" skit with show writers John T. Reynolds and Philip McGrade ||||
| 689 | June 16, 2008 (2008-06-16) | Alfred Molina, Salman Rushdie | N/A |
| Jamie Denbo does a skit as Hillary Clinton ||||
| 690 | June 17, 2008 (2008-06-17) | Virginia Madsen, Darin Strauss | John Hiatt |
| 691 | June 18, 2008 (2008-06-18) | Don Cheadle, Olivia Thirlby | N/A |
| 692 | June 19, 2008 (2008-06-19) | Lewis Black, Billy Bob Thornton | The Boxmasters |
| 693 | June 20, 2008 (2008-06-20) | Jeffrey Tambor | The Fratellis |
| "The J.K. Rowling Show" skit with writer Philip McGrade ||||
| 694 | June 23, 2008 (2008-06-23) | David Hasselhoff, Miriam Shor | Amos Lee |
| 695 | June 24, 2008 (2008-06-24) | Lawrence Block, Chris O'Donnell | Phantom Planet |
| 696 | June 25, 2008 (2008-06-25) | Stanley Bing, Sigourney Weaver | Three 6 Mafia |
| 697 | June 26, 2008 (2008-06-26) | James McAvoy, Bengt Washburn | N/A |
| Murder She Wrote sketch with Alfred Molina and show writer John T. Reynolds. ||||
| 698 | June 27, 2008 (2008-06-27) | Holly Hunter | N/A |
| Henry Winkler drops in for a comedy bit. ||||
| 699 | June 30, 2008 (2008-06-30) | Tricia Helfer, Steven Wright | N/A |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 700 | July 1, 2008 (2008-07-01) | Tyler Matthew Davis, Richard Lewis | Duffy |
| 701 | July 14, 2008 (2008-07-14) | Chris Isaak, Debbie Reynolds | N/A |
| 702 | July 15, 2008 (2008-07-15) | Julie Andrews, Raymond Crowe | N/A |
| 703 | July 16, 2008 (2008-07-16) | Ben Kingsley | Popovich Comedy Pet Theater |
| 704 | July 17, 2008 (2008-07-17) | Ron Perlman, Rita Rudner | N/A |
| 705 | July 18, 2008 (2008-07-18) | Criss Angel, Mary Steenburgen | N/A |
| Bit with show writer John T. Reynolds as Ferguson, and Ferguson as Michael Caine ||||
| 706 | July 21, 2008 (2008-07-21) | Jarod Miller, Aisha Tyler | Keaton Simons |
| 707 | July 22, 2008 (2008-07-22) | Julie Chen, Adam Scott | Ricky Skaggs |
| 708 | July 23, 2008 (2008-07-23) | Wayne Newton, Les Stroud | Curt Smith |
| 709 | July 24, 2008 (2008-07-24) | Lance Morrow, Amanda Peet | N/A |
| 710 | July 25, 2008 (2008-07-25) | Xzibit | Griffin House |
| 711 | July 28, 2008 (2008-07-28) | Eric Idle, Nancy Travis | N/A |
| 712 | July 29, 2008 (2008-07-29) | Belinda Carlisle, Jet Li | Belinda Carlisle |
| 713 | July 30, 2008 (2008-07-30) | Julie Chen, Tom Sullivan, Michelle Yeoh | LS3 |
| 714 | July 31, 2008 (2008-07-31) | Jean-Michel Cousteau, Will Ferrell | N/A |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 715 | August 1, 2008 (2008-08-01) | Rainn Wilson, Cory Kahaney | The Hold Steady perform "Construct the Summer" from Stay Positive |
| Skit with Ferguson as himself and Tom Lennon as a CBS executive ||||
| 716 | August 4, 2008 (2008-08-04) | Cheryl Hines, Harry Shearer | Jakob Dylan |
| 717 | August 5, 2008 (2008-08-05) | Regis Philbin, Paula Patton | N/A |
| 718 | August 6, 2008 (2008-08-06) | Eddie Izzard, Julie Chen | N/A |
| 719 | August 7, 2008 (2008-08-07) | Jack Black, Tom Arnold (actor) | Conor Oberst |
| 720 | August 8, 2008 (2008-08-08) | Toby Keith | Toby Keith |
| 721 | August 11, 2008 (2008-08-11) | Robert Downey Jr., Amy Smart | N/A |
| 722 | August 12, 2008 (2008-08-12) | Kate Mara, Kiefer Sutherland | N/A |
| 723 | August 13, 2008 (2008-08-13) | Julie Chen, Hugh Moore | music from Henry Poole Is Here |
| 724 | August 14, 2008 (2008-08-14) | Ben Kingsley, Idina Menzel | Idina Menzel |
| 725 | August 15, 2008 (2008-08-15) | Radha Mitchell | Comedian Aaron Karo |
| Cold open: Late Late Show version of the opening scene from Apocalypse Now Skit with Ferguson as Simon Cowell and show writer John T. Reynolds as the bartender ||||

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 726 | September 1, 2008 (2008-09-01) | Julie Bowen, Jonathan Winters | Priscilla Ahn plays "Leave the Light On" |
| 727 | September 2, 2008 (2008-09-02) | Katey Sagal, Nathan Fillion | N/A |
| 728 | September 3, 2008 (2008-09-03) | Julie Chen, Maria Bello | Shelby Lynne plays "How Can I Be Sure" |
| Skit with James Adomian as George W. Bush ||||
| 729 | September 4, 2008 (2008-09-04) | Eva Longoria, Neal McDonough | N/A |
| 730 | September 5, 2008 (2008-09-05) | Kal Penn | Gabe Dixon Band plays "Till You're Gone" |
| 731 | September 8, 2008 (2008-09-08) | Julie Chen, Neil Patrick Harris, Sophia Myles | N/A |
| 732 | September 9, 2008 (2008-09-09) | Russell Brand | N/A |
| John T. Reynolds does a comedic bit impersonating Ferguson in the cold open. ||||
| 733 | September 10, 2008 (2008-09-10) | Alice Cooper, AnnaLynne McCord | Alice Cooper performs "Elected" from Billion Dollar Babies |
| Monologue on the media's coverage of politics and the importance of voting ||||
| 734 | September 11, 2008 (2008-09-11) | Lynn Ferguson, Lance Morrow | N/A |
| Cold open: short, serious discussion of Ferguson's views on this anniversary of the September 11, 2001 terrorist attacks ||||
| 735 | September 12, 2008 (2008-09-12) | Lena Heady | N/A |
| When Seann William Scott, a scheduled guest, is stuck in traffic, Ferguson improvises with an interview of segment producer Lisa Ammerman, who had been in charge of coordinating Scott's appearance ||||
| 736 | September 15, 2008 (2008-09-15) | Julie Chen, Jason Biggs | The Ting Tings |
| 737 | September 16, 2008 (2008-09-16) | Paulina Porizkova, Ken Tucker | Tally Hall |
| 738 | September 17, 2008 (2008-09-17) | Alan Alda, Illeana Douglas | N/A |
| 739 | September 18, 2008 (2008-09-18) | Jason Segel | Dr Dog Comedian Steve Hofstetter |
| First puppet-style cold open featuring a stuffed monkey, who also handles the "What Did We Learn on the Show Tonight, Craig?" closing segment ||||
| 740 | September 19, 2008 (2008-09-19) | Kristen Bell, Josh Radnor | N/A |
| 741 | September 22, 2008 (2008-09-22) | Denis Leary, Marianne Jean-Baptiste | N/A |
| 742 | September 23, 2008 (2008-09-23) | John Krasinski, Lisa Masterson | N/A |
| 743 | September 24, 2008 (2008-09-24) | Michael Clarke Duncan, Shirley Manson | Jamie Lidell |
| 744 | September 25, 2008 (2008-09-25) | Tim Gunn, Elizabeth Reaser | N/A |
| 745 | September 26, 2008 (2008-09-26) | Drew Carey, Tony Parker | Lady Antebellum |
| 746 | September 29, 2008 (2008-09-29) | Melina Kanakaredes, Gina Carano | Amy Macdonald |
| 747 | September 30, 2008 (2008-09-30) | Tim Daly, Anna Friel | Alice Cooper |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 748 | October 1, 2008 (2008-10-01) | Jennifer Love Hewitt, Jim Parsons | N/A |
| 749 | October 2, 2008 (2008-10-02) | Lauren Graham, Patrick Pedraja | Michael Franti & Spearhead |
| 750 | October 3, 2008 (2008-10-03) | Margaret Cho, Randy Newman | Randy Newman |
| 751 | October 6, 2008 (2008-10-06) | Seth Green, Betty White | Smothers Brothers |
| 752 | October 7, 2008 (2008-10-07) | Thandie Newton, Barry Sonnenfeld | Jim Bianco |
| 753 | October 8, 2008 (2008-10-08) | Rufus Sewell | Natasha Bedingfield |
| 754 | October 9, 2008 (2008-10-09) | Russell Crowe, Jennifer Esposito | No Age |
| 755 | October 10, 2008 (2008-10-10) | Little Britain (Matt Lucas & David Walliams) | Tom Morello |
| 756 | October 20, 2008 (2008-10-20) | Dee Dee Myers, Noah Emmerich | N/A |
| 757 | October 21, 2008 (2008-10-21) | Rachael Ray, Leanne Marshall | Laura Marling |
| 758 | October 22, 2008 (2008-10-22) | Chris Matthews, Christopher Mintz-Plasse | N/A |
| 759 | October 23, 2008 (2008-10-23) | John Malkovich | Little Jackie |
| 760 | October 24, 2008 (2008-10-24) | Mo'Nique | Bill Santiago, Lenka |
| 761 | October 27, 2008 (2008-10-27) | Kathy Griffin, Carl Bernstein | N/A |
| 762 | October 28, 2008 (2008-10-28) | Pepe the King Prawn, Saffron Burrows | X |
| 763 | October 29, 2008 (2008-10-29) | Ben Stein, Parminder Nagra | New York Dolls |
| 764 | October 30, 2008 (2008-10-30) | Kevin Smith, Kaitlin Olson | The Damned |
| 765 | October 31, 2008 (2008-10-31) | Lauren Graham | The Damned |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 766 | November 3, 2008 (2008-11-03) | Bill Maher | N/A |
| 767 | November 5, 2008 (2008-11-05) | Paris Hilton, Drew Pinsky | N/A |
| 768 | November 6, 2008 (2008-11-06) | Elizabeth Banks, Jay Mohr | N/A |
| 769 | November 7, 2008 (2008-11-07) | Christian Slater, Luke Dempsey | Eric Hutchinson |
| 770 | November 10, 2008 (2008-11-10) | Mark Harmon, Ron White | N/A |
| 771 | November 11, 2008 (2008-11-11) | Coolio, Tom Dreesen and Tim Reid | Coolio |
| 772 | November 12, 2008 (2008-11-12) | Seann William Scott | Kathy Kinney |
| 773 | November 13, 2008 (2008-11-13) | Andy Richter | Cold War Kids |
| 774 | November 14, 2008 (2008-11-14) | Jim Parsons | Ray Davies |
| 775 | November 17, 2008 (2008-11-17) | Poppy Montgomery, Nick Hornby | N/A |
| 776 | November 18, 2008 (2008-11-18) | Kevin Bacon, Sarah Shahi | The Bacon Brothers |
| 777 | November 19, 2008 (2008-11-19) | James Lipton, Sara Gilbert | Sarah McLachlan |
| 778 | November 20, 2008 (2008-11-20) | Larry the Cable Guy | Third Day |
| 779 | November 21, 2008 (2008-11-21) | George Hamilton, Cobie Smulders | N/A |
| 780 | November 24, 2008 (2008-11-24) | Eamonn Walker | Low vs Diamond |
| 781 | November 25, 2008 (2008-11-25) | Neil Patrick Harris | Julia Fordham |
| First hand-puppet appearance in a cold open (horse). ||||
| 782 | November 26, 2008 (2008-11-26) | Adam Arkin, Jen Kirkman | Adele |
| 783 | November 27, 2008 (2008-11-27) | Tony Curtis, Megalyn Echikunwoke | Oppenheimer |
| 784 | November 28, 2008 (2008-11-28) | Kristin Chenoweth, Diedrich Bader | N/A |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 785 | December 8, 2008 (2008-12-08) | Chi McBride | Seal |
| Ferguson eulogizes his mother, Janet Ferguson. ||||
| 786 | December 9, 2008 (2008-12-09) | Elizabeth Banks, Ken Tucker | N/A |
| 787 | December 10, 2008 (2008-12-10) | Alfred Molina | Tokyo Police Club |
| 788 | December 11, 2008 (2008-12-11) | Brooke Shields, Dom Irrera | N/A |
| 789 | December 12, 2008 (2008-12-12) | Carrie Fisher, Julie Benz | N/A |
| 790 | December 15, 2008 (2008-12-15) | Carmen Electra, Dennis Lehane | N/A |
| 791 | December 16, 2008 (2008-12-16) | Don Rickles, Joanna Garcia | N/A |
| 792 | December 17, 2008 (2008-12-17) | Samuel L. Jackson | Death Cab for Cutie |
| 793 | December 18, 2008 (2008-12-18) | Julia Ormond, Michael Connelly | N/A |
| 794 | December 19, 2008 (2008-12-19) | Jeffrey Tambor, Patrick Keane | N/A |
| 795 | December 22, 2008 (2008-12-22) | Joel McHale | Matt Nathanson |
| 796 | December 23, 2008 (2008-12-23) | Billy Bob Thornton | Conor Oberst |
| 797 | December 26, 2008 (2008-12-26) | Kristen Bell, Wolfgang Puck | N/A |

## 2009
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 798 | January 5, 2009 (2009-01-05) | Richard Lewis | N/A |
| 799 | January 6, 2009 (2009-01-06) | Marisa Tomei, Pauley Perrette | N/A |
| 800 | January 7, 2009 (2009-01-07) | William Shatner | Jazmine Sullivan |
| 801 | January 8, 2009 (2009-01-08) | Amy Sedaris, Dennis Haysbert | N/A |
| 802 | January 9, 2009 (2009-01-09) | Ted Danson, Paula Poundstone | N/A |
| 803 | January 12, 2009 (2009-01-12) | John Corbett, Tracie Thoms | John Corbett |
| 804 | January 13, 2009 (2009-01-13) | Kristin Scott Thomas, Joshua Jackson | N/A |
| 805 | January 14, 2009 (2009-01-14) | John Waters, Norah O'Donnell | N/A |
| 806 | January 15, 2009 (2009-01-15) | Wanda Sykes | Glasvegas |
| Ferguson talks about Sully Sullenberger's emergency landing of US Airways Flight 1549 on the Hudson in New York, and tells about his own first solo flight. ||||
| 807 | January 16, 2009 (2009-01-16) | Dev Patel | Greg Proops |
| 808 | January 19, 2009 (2009-01-19) | Sarah Chalke, Jeffrey Dean Morgan | Seal |
| 809 | January 20, 2009 (2009-01-20) | Joel McHale | The Submarines |
| 810 | January 21, 2009 (2009-01-21) | Trace Adkins, Perez Hilton | Trace Adkins |
| 811 | January 22, 2009 (2009-01-22) | Jennifer Love Hewitt, Matthew Rhys | N/A |
| 812 | January 23, 2009 (2009-01-23) | James Earl Jones | N/A |
| 813 | January 26, 2009 (2009-01-26) | Chris Matthews | Comedian Paul C. Morrissey |
| First musical cold open: Ferguson lip syncs to "She Taught Me How to Yodel" sung by Frank Ifield ||||
| 814 | January 27, 2009 (2009-01-27) | RZA, Jared Harris | RZA |
| 815 | January 28, 2009 (2009-01-28) | Cuba Gooding Jr., Freida Pinto | N/A |
| Musical cold open: puppets lip sync to "Raindrops Keep Fallin' On My Head" ||||
| 816 | January 29, 2009 (2009-01-29) | Dominic Monaghan, Rosemarie DeWitt | N/A |
| Musical cold open; puppets lip sync to "The Lonely Goatherd" as performed by Julie Andrews and company from The Sound of Music ||||
| 817 | January 30, 2009 (2009-01-30) | Michael Sheen, Russell Peters | Sharon Jones & the Dap-Kings |
| Musical cold open: puppets lip sync to "Fire" as performed by Arthur Brown ||||

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 818 | February 2, 2009 (2009-02-02) | Alfred Molina | Magician Lance Burton |
| First night of Magic Week, with nightly introductions by Neil Patrick Harris ||||
| 819 | February 3, 2009 (2009-02-03) | Robin Williams | Magician Jason Randall |
| 820 | February 4, 2009 (2009-02-04) | Samuel L. Jackson | Magician Jason Hudy |
| 821 | February 5, 2009 (2009-02-05) | Garry Shandling | Magician Ed Alonzo |
| The "roof leak" episode: Ferguson shows up prepared in a yellow raincoat. ||||
| 822 | February 6, 2009 (2009-02-06) | Kristen Bell, Alex Kapranos | Franz Ferdinand performs "Ulysses" |
| Last night of Magic Week: Assisted by magician Ed Alonzo, Ferguson cuts Kristen Bell in half, and later talks with fellow Glaswegian Alex Kapranos of the band Franz Ferdinand. ||||
| 823 | February 9, 2009 (2009-02-09) | Michael Clarke Duncan, Richard Zoglin | Adele |
| 824 | February 10, 2009 (2009-02-10) | Sean Combs, Olivia Williams | N/A |
| 825 | February 11, 2009 (2009-02-11) | Steve Coogan, Connie Britton | N/A |
| 826 | February 12, 2009 (2009-02-12) | Lewis Black, Shirley Manson Drop-in guest Steven Wright | N/A |
| Ferguson briefly tells guest Shirley Manson the history of the long running Paul McCarney/Angela Lansbury picture gag. ||||
| 827 | February 13, 2009 (2009-02-13) | Tom Selleck Drop-in guest Tom Arnold | Glen Campbell performs "Rhinestone Cowboy" |
| 828 | February 16, 2009 (2009-02-16) | David Boreanaz, Philip Johnson | Zac Brown Band performs "Chicken Fried" |
| 829 | February 17, 2009 (2009-02-17) | Bill Maher, Chris Klein | N/A |
| 830 | February 18, 2009 (2009-02-18) | Wynonna, Variety journalist Peter Bart | N/A |
| 831 | February 19, 2009 (2009-02-19) | Paula Abdul, Carl Edwards Drop-in guest Steven Wright | TBA |
| 832 | February 20, 2009 (2009-02-20) | Rosie O'Donnell Drop-in guest Dave Foley | The Knux sings "Bang, Bang" |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 833 | March 2, 2009 (2009-03-02) | Paris Hilton, Dee Dee Myers | N/A |
| 834 | March 3, 2009 (2009-03-03) | Kristin Davis, Wolfgang Puck | N/A |
| 835 | March 4, 2009 (2009-03-04) | Desmond Tutu | N/A |
| 836 | March 5, 2009 (2009-03-05) | Holly Hunter | Andrew Bird performs "Oh No" |
| 837 | March 6, 2009 (2009-03-06) | Amy Adams; Betty White drops in for a comedy bit | M Ward performs "To Save Me" Comedian Nick Griffin |
| 838 | March 9, 2009 (2009-03-09) | Jason Segel, Dave Attell | N/A |
| 839 | March 10, 2009 (2009-03-10) | Rosario Dawson, Gordon Ramsay | N/A |
| 840 | March 11, 2009 (2009-03-11) | Tim Daly, Kara Cooney | N/A |
| 841 | March 12, 2009 (2009-03-12) | Jim Parsons | Sara Bareilles performs "Gravity". |
| 842 | March 13, 2009 (2009-03-13) | Christina Ricci | Mike Birbiglia |
| 843 | March 16, 2009 (2009-03-16) | Regis Philbin | The Upper Crust performs "We're Finished With Finishing School" |
| 844 | March 17, 2009 (2009-03-17) | Julia Louis-Dreyfus | Dropkick Murphys performs "Flannigan's Ball" |
| 845 | March 18, 2009 (2009-03-18) | Steven Wright, Rashida Jones | N/A |
| Musical cold open: a reprise of "She Taught Me How to Yodel" sung by Frank Ifield, this time lip sync'd by puppets Kronos and friends. ||||
| 846 | March 23, 2009 (2009-03-23) | Paul Rudd | Comedian George Wallace |
| 847 | March 24, 2009 (2009-03-24) | Virginia Madsen, Jason Ritter | Chicago |
| 848 | March 25, 2009 (2009-03-25) | Jerry O'Connell, Tucker Albrizzi, Patrick Pedraja | Ra Ra Riot performs "Can You Tell" |
| 849 | March 30, 2009 (2009-03-30) | William Shatner, Regina King | N/A |
| 850 | March 31, 2009 (2009-03-31) | Isabella Rossellini, Linda Cardellini Drop-in guest Steven Wright Thomas Lennon and Robert Ben Garant perform a Reno 911 skit | N/A |

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 851 | April 1, 2009 (2009-04-01) | Jennifer Tilly | Heidi Newfield |
| Comedy bit with Ferguson as Bono and show writer John T. Reynolds as Ferguson ||||
| 852 | April 2, 2009 (2009-04-02) | Brittany Murphy, Christopher Gorham; drop-in guest Steven Wright | N/A |
| 853 | April 3, 2009 (2009-04-03) | Zooey Deschanel, Lance Krall | N/A |
| 854 | April 13, 2009 (2009-04-13) | Dwight Yoakam, Mary McCormack | N/A |
| Actress Mary McCormack gifts Ferguson with the soon-to-be-iconic rattlesnake mug from the American International Rattlesnake Museum in Albuquerque, New Mexico. He will use it on camera for the remainder of his tenure on The Late Late Show. ||||
| 855 | April 14, 2009 (2009-04-14) | Adam Goldberg, Anna Gunn | Brett Dennen |
| 856 | April 15, 2009 (2009-04-15) | Michael Caine, Matt Baetz | Matt Baetz, stand-up comedian |
| 857 | April 16, 2009 (2009-04-16) | Madeleine Albright, Amy Smart | N/A |
| 858 | April 17, 2009 (2009-04-17) | Jessica Lange, Thomas Lennon | Madeleine Peyroux |
| 859 | April 20, 2009 (2009-04-20) | Simon Cowell | Erin McCarley |
| 860 | April 21, 2009 (2009-04-21) | Rob Morrow, Jean-Michel Cousteau | N/A |
| 861 | April 22, 2009 (2009-04-22) | Bob Barker, Jean Smart | N/A |
| 862 | April 23, 2009 (2009-04-23) | Teri Hatcher | Martina McBride |
| 863 | April 24, 2009 (2009-04-24) | Eddie Izzard | Chris Botti |
| 864 | April 27, 2009 (2009-04-27) | Shirley Manson, Breckin Meyer | N/A |
| 865 | April 28, 2009 (2009-04-28) | John McEnroe | N/A |
| 866 | April 29, 2009 (2009-04-29) | Kenneth Branagh | Antony and the Johnsons |
| 867 | April 30, 2009 (2009-04-30) | Michael Douglas, Carrie Ann Inaba | N/A |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 868 | May 1, 2009 (2009-05-01) | Ryan Reynolds, Ricky Hatton | N/A |
| 869 | May 4, 2009 (2009-05-04) | Jeffrey Dean Morgan, Stana Katic | N/A |
| 870 | May 5, 2009 (2009-05-05) | George Hamilton | Jenny Lewis |
| 871 | May 6, 2009 (2009-05-06) | Melina Kanakaredes, Nathan Fillion | Zac Brown Band plays "Whatever It Is" |
| 872 | May 7, 2009 (2009-05-07) | Matthew McConaughey, Cokie Roberts | N/A |
| 873 | May 8, 2009 (2009-05-08) | Amy Smart, Kunal Nayyar | N/A |
| 874 | May 11, 2009 (2009-05-11) | Steven Wright, Bryce Dallas Howard; drop-in guest Henry Winkler | N/A |
| 875 | May 12, 2009 (2009-05-12) | Paulina Porizkova, Andy Nulman | N/A |
| 876 | May 13, 2009 (2009-05-13) | Laurence Fishburne, Paula Poundstone | N/A |
| 877 | May 14, 2009 (2009-05-14) | Howie Mandel, Laura Lippman | N/A |
| 878 | May 15, 2009 (2009-05-15) | Ewan McGregor | All American Rejects play "When the Wind Blows" |
| Ferguson, Ewan McGregor and writer Philip McGrade do an "ESPN UK" skit ||||
| 879 | May 18, 2009 (2009-05-18) | Justin Long, Lawrence Block | N/A |
| Cold open lip sync number with puppets to Britney Spears' "Oops!... I Did It Again"; Dan McVicar of The Bold and the Beautiful drops in for a comedy bit. ||||
| 880 | May 19, 2009 (2009-05-19) | Kathy Griffin, Nelson George | N/A |
| 881 | May 20, 2009 (2009-05-20) | Guy Pearce | Hattie Hayridge, stand-up routine; Hensley plays "Beautiful" |
| 882 | May 21, 2009 (2009-05-21) | John Waters | Manda Mosher plays "Lay Me Down" |
| 883 | May 22, 2009 (2009-05-22) | Mark Ruffalo, Mindy Kaling | The Decemberists play "The Hazards of Love 2" |
| 884 | May 25, 2009 (2009-05-25) | Bob Saget, P. W. Singer | N/A |
| 885 | May 26, 2009 (2009-05-26) | Chris Isaak, Moon Bloodgood | Chris Isaak plays "You Don't Cry Like I Do" |
| Special guest Dave Foley drops in for a bit with writer John T. Reynolds playing the CBS censor. ||||

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 886 | June 1, 2009 (2009-06-01) | Mary-Louise Parker, Guillermo del Toro | Tori Amos performs "Welcome to England" from Abnormally Attracted to Sin |
| 887 | June 2, 2009 (2009-06-02) | Denis Leary; special guest Betty White does a comic bit; Fozzy Bear appears in the cold open and closing segments | Diane Birch performs "Nothing But a Miracle" from Bible Belt |
| 888 | June 3, 2009 (2009-06-03) | Jeffrey Tambor, Gabrielle Anwar | N/A |
| Musical cold open: lip sync to "Istanbul" by They Might Be Giantsby Ferguson and company ||||
| 889 | June 4, 2009 (2009-06-04) | Elizabeth Perkins, Mark Burnett | Bernie Williams performs "Go For It" from Moving Forward |
| 890 | June 5, 2009 (2009-06-05) | Chris Kattan, Henry Cho | Comedian Henry Cho |
| 891 | June 8, 2009 (2009-06-08) | Kevin Bacon, Michael Irvin | N/A |
| 892 | June 9, 2009 (2009-06-09) | Dame Edna Everage; drop-in guest Joel McHale | N/A |
| 893 | June 10, 2009 (2009-06-10) | Chris Matthews; Tim Meadows appears in a comedy bit | Theresa Andersson performs "Na Na Na" from Hummingbird, Go! |
| 894 | June 11, 2009 (2009-06-11) | Larry King, Anna Friel | N/A |
| Musical cold open: lip sync to Jason Mraz's "I'm Yours" by Ferguson and company ||||
| 895 | June 12, 2009 (2009-06-12) | Dane Cook, Peter Travers | N/A |
| 896 | June 15, 2009 (2009-06-15) | Holly Hunter | Camera Obscura performs "French Navy" from My Maudlin Career |
| 897 | June 16, 2009 (2009-06-16) | Jeff Foxworthy | Gavin DeGraw performs "Dancing Shoes" from Free |
| 898 | June 17, 2009 (2009-06-17) | Julia Ormond, Derrick Pitts | N/A |
| 899 | June 18, 2009 (2009-06-18) | Sandra Bullock | Metric performs "Help I'm Alive" from Fantasies, comedian David Feldman |
| 900 | June 19, 2009 (2009-06-19) | Bryan Cranston | Ben Kweller performs "Wantin' Her Again" from Changing Horses |
| 901 | June 22, 2009 (2009-06-22) | Marion Cotillard, Michael Musto | N/A |
| 902 | June 23, 2009 (2009-06-23) | Jim Parsons | N/A |
| 903 | June 24, 2009 (2009-06-24) | Mary Steenburgen | Bettye LaVette sings "A Change Is Gonna Come"; comedian Todd Sawyer |
| 904 | June 25, 2009 (2009-06-25) | Larry David, Wolfgang Puck | N/A |
| 905 | June 26, 2009 (2009-06-26) | Lisa Kudrow, James Frey | Chairlift performs "Bruises" from Does You Inspire You |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 906 | July 6, 2009 (2009-07-06) | Eric Idle, Dr. Lisa Masterson | N/A |
| 907 | July 7, 2009 (2009-07-07) | Evan Rachel Wood, Christopher Gorham | N/A |
| 908 | July 8, 2009 (2009-07-08) | Julie Chen, Michael Ian Black | Will Dailey |
| 909 | July 9, 2009 (2009-07-09) | Jeff Goldblum, Jackie Collins | N/A |
| 910 | July 10, 2009 (2009-07-10) | Ray Romano | Michael Bublé |
| 911 | July 13, 2009 (2009-07-13) | Selma Blair, Connie Schultz | N/A |
| 912 | July 14, 2009 (2009-07-14) | John Larroquette, Will Dailey | Charlie Viracola |
| 913 | July 15, 2009 (2009-07-15) | Rosie Perez, Mike Massimino | N/A |
| 914 | July 16, 2009 (2009-07-16) | Isaac Mizrahi, Shohreh Aghdashloo | N/A |
| 915 | July 17, 2009 (2009-07-17) | Paris Hilton, Alan Furst | Ray LaMontagne |
| 916 | July 20, 2009 (2009-07-20) | Margaret Cho, Michael Lewis | Eric Church |
| 917 | July 21, 2009 (2009-07-21) | Gerard Butler, Jackie Collins | N/A |
| Musical cold open: Lip sync to "Fireball", theme song to Fireball XL5, introduced by Paris Hilton ||||
| 918 | July 22, 2009 (2009-07-22) | Tom Lennon, Kelly Rowland | Dobie Maxwell |
| 919 | July 23, 2009 (2009-07-23) | Cheryl Hines, Ben Mezrich | N/A |
| 920 | July 24, 2009 (2009-07-24) | Rashida Jones, José Andrés | Jim Breuer |
| 921 | July 27, 2009 (2009-07-27) | Chelsea Handler, Richard Wolffe | N/A |
| 922 | July 28, 2009 (2009-07-28) | Christiane Amanpour, Johnny Galecki | N/A |
| 923 | July 29, 2009 (2009-07-29) | Toni Collette, Rodney Carrington | N/A |
| 924 | July 30, 2009 (2009-07-30) | James Spader, Rose Byrne | N/A |
| 925 | July 31, 2009 (2009-07-31) | Saffron Burrows | N/A |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 926 | August 3, 2009 (2009-08-03) | Edie Falco, Les Stroud | Lisa Landry |
| 927 | August 4, 2009 (2009-08-04) | Tony Shalhoub, Minka Kelly | N/A |
| 928 | August 5, 2009 (2009-08-05) | Wolf Blitzer, Rose Byrne | N/A |
| 929 | August 6, 2009 (2009-08-06) | Zooey Deschanel | Glasvegas |
| 930 | August 7, 2009 (2009-08-07) | Don Rickles | Sharon Jones & The Dap-Kings |
| 931 | August 10, 2009 (2009-08-10) | Carrot Top, Alexis Bledel | N/A |
| 932 | August 11, 2009 (2009-08-11) | Betty White, Mitch Albom | Bonnie Raitt & Taj Mahal |
| 933 | August 12, 2009 (2009-08-12) | Eric Bana, Holly Williams | N/A |
| 934 | August 13, 2009 (2009-08-13) | Jon Cryer | N/A |
| 935 | August 14, 2009 (2009-08-14) | Liza Minnelli, Kara Cooney | N/A |
| 936 | August 31, 2009 (2009-08-31) | Emily Deschanel, Terry Crews | N/A |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 937 | September 1, 2009 (2009-09-01) | Quentin Tarantino | N/A |
| 938 | September 2, 2009 (2009-09-02) | Mila Kunis | N/A |
| 939 | September 3, 2009 (2009-09-03) | Carrie Fisher, DJ Qualls | N/A |
| 940 | September 4, 2009 (2009-09-04) | Radha Mitchell, Jason Ritter | N/A |
| 941 | September 7, 2009 (2009-09-07) | Juliette Lewis, Alex O'Loughlin Betty White reads from Ferguson's American on Purpose | Juliette Lewis performs "Fantasy Bar" |
| 942 | September 8, 2009 (2009-09-08) | Neil Patrick Harris Dame Edna Everidge reads from American on Purpose | Spencer Day performs "'Till You Come to Me" |
| 943 | September 9, 2009 (2009-09-09) | Danny DeVito Kevin Bacon reads from American on Purpose | N/A |
| 944 | September 10, 2009 (2009-09-10) | Audrey Tautou, Ron Livingston | N/A |
| Ferguson discusses Representative Joe Wilson's outburst during President Obama's September 9th address to a joint session of Congress. ||||
| 945 | September 11, 2009 (2009-09-11) | Drew Carey, Mindy Kaling Holly Hunter reads from American on Purpose | N/A |
| 946 | September 21, 2009 (2009-09-21) | Marg Helgenberger, Dulé Hill John Waters reads from American on Purpose | Black Joe Lewis & the Honeybears perform "Sugarfoot" from Tell 'Em What... |
| 947 | September 22, 2009 (2009-09-22) | Reba McEntire, Dave Annable | Reba McEntire performs "Consider Me Gone" from Keep On Loving You |
| 948 | September 23, 2009 (2009-09-23) | Jennifer Love Hewitt, Ken Tucker | Arctic Monkeys |
| 949 | September 24, 2009 (2009-09-24) | Jason Schwartzman, Angela Kinsey Reba McEntire reads from American on Purpose | N/A |
| 950 | September 25, 2009 (2009-09-25) | Ted Danson, Chris Miller, Phil Lord Marg Helgenberger reads from American on Purpose | N/A |
| 951 | September 28, 2009 (2009-09-28) | Chris O'Donnell, Paula Poundstone | Comedienne Paula Poundstone |
| 952 | September 29, 2009 (2009-09-29) | James Spader | Comedienne Cathy Ladman; Laura Izibor performs "From My Heart to Yours" from Let the Truth Be Told |
| 953 | September 30, 2009 (2009-09-30) | Jenna Elfman, Dom Irrera | Comedian Dom Irrera |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 954 | October 1, 2009 (2009-10-01) | Patricia Arquette, Dominic Cooper | N/A |
| 955 | October 2, 2009 (2009-10-02) | Tim Gunn, Cobie Smulders | Lynyrd Skynyrd |
| 956 | October 5, 2009 (2009-10-05) | Michael Sheen, Viola Davis | Jack Ingram |
| 957 | October 6, 2009 (2009-10-06) | Julia Louis-Dreyfus | The Avett Brothers |
| 958 | October 7, 2009 (2009-10-07) | Rachel Bilson, David Milch | N/A |
| 959 | October 8, 2009 (2009-10-08) | Jean Reno, Sophia Bush | N/A |
| 960 | October 9, 2009 (2009-10-09) | Gerard Butler | Phoenix |
| 961 | October 12, 2009 (2009-10-12) | David Boreanaz, Mitch Albom | Dierks Bentley |
| 962 | October 13, 2009 (2009-10-13) | Tim Robbins, Adam Goldberg | N/A |
| 963 | October 14, 2009 (2009-10-14) | Kristen Bell, Robert Carlyle | N/A |
| 964 | October 15, 2009 (2009-10-15) | Forest Whitaker, Adam Savage, Jamie Hyneman | A Fine Frenzy |
| 965 | October 16, 2009 (2009-10-16) | Michelle Monaghan, Toby Keith | Toby Keith |
| "Party at Elton John's House" sketch with show writer John T. Reynolds as Ferguson; Ferguson as Elton John; Salman Rushdie as himself, and Bradley Laise as the tiny dancer. ||||
| 966 | October 26, 2009 (2009-10-26) | Sherri Shepherd, Alex Dryden | N/A |
| 967 | October 27, 2009 (2009-10-27) | Alicia Silverstone, Salman Rushdie | N/A |
| Musical cold open lip sync to "In the Navy" by the Village People ||||
| 968 | October 28, 2009 (2009-10-28) | Madeleine Albright | Rodrigo y Gabriela |
| 969 | October 29, 2009 (2009-10-29) | Newt Gingrich | N/A |
| 970 | October 30, 2009 (2009-10-30) | Lauren Graham, Jessalyn Gilsig | Fruit Bats |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 971 | November 2, 2009 (2009-11-02) | Billy Connolly, George Eads | Jack Ingram performs "Seeing Stars" |
| 972 | November 3, 2009 (2009-11-03) | Valerie Bertinelli, Dave Barry; Gerard Butler reads from Ferguson's autobiography | N/A |
| 973 | November 4, 2009 (2009-11-04) | Mo'Nique, Stephen Fry | N/A |
| Discusses including awkward pauses, which will become a regular device on the show. ||||
| 974 | November 5, 2009 (2009-11-05) | Denis Leary, Jena Malone | N/A |
| 975 | November 6, 2009 (2009-11-06) | Ewan McGregor, Anthony Zuiker | Regina Spektor performs "Eet" |
| 976 | November 9, 2009 (2009-11-09) | Carla Gugino, Dennis Lehane; Josh Robert Thompson appears in skit as Arnold Schwarzenegger | N/A |
| When his staff doesn't perform as expected, Ferguson enjoys hassling show producer Michael Naidus for several days in a row, an activity that will eventually become a regular feature on the show. ||||
| 977 | November 10, 2009 (2009-11-10) | Adam Arkin, Nina García | N/A |
| 978 | November 11, 2009 (2009-11-11) | Kenneth Branagh | N/A |
| 979 | November 12, 2009 (2009-11-12) | Trace Adkins | Nick Griffin |
| 980 | November 13, 2009 (2009-11-13) | Harry Connick Jr., Peter Sagal | N/A |
| 981 | November 16, 2009 (2009-11-16) | LL Cool J, Mindy Kaling | N/A |
| When the audience sides with producer Michael Naidus, it provides Ferguson with much ad lib material for several rants and a unique ending vignette. ||||
| 982 | November 17, 2009 (2009-11-17) | Woody Harrelson, Joe Theismann | N/A |
| 983 | November 18, 2009 (2009-11-18) | David Duchovny, Lewis Black | N/A |
| 984 | November 19, 2009 (2009-11-19) | Sandra Bullock, Ben Foster | N/A |
| 985 | November 20, 2009 (2009-11-20) | Neil Patrick Harris | David Grey |
| 986 | November 23, 2009 (2009-11-23) | Margaret Cho, Carl Edwards | N/A |
| 987 | November 24, 2009 (2009-11-24) | Maria Bello, Peter Capaldi | Relentless7 |
| 988 | November 25, 2009 (2009-11-25) | Robin Wright, Wolfgang Puck | N/A |
| 989 | November 30, 2009 (2009-11-30) | Michael Sheen, Carl Bernstein | N/A |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 990 | December 1, 2009 (2009-12-01) | Joel McHale | The Swell Season |
| 991 | December 2, 2009 (2009-12-02) | Paul Shaffer, Shohreh Aghdashloo | N/A |
| 992 | December 3, 2009 (2009-12-03) | George Lopez | OneRepublic performs "Counting Stars" |
| 993 | December 4, 2009 (2009-12-04) | Emily Blunt, David Bianculli | N/A |
| 994 | December 7, 2009 (2009-12-07) | Shirley Manson, Mitch Albom | N/A |
| 995 | December 8, 2009 (2009-12-08) | Michael Clarke Duncan, Gillian Jacobs | N/A |
| 996 | December 9, 2009 (2009-12-09) | Morgan Freeman | Overtone |
| 997 | December 10, 2009 (2009-12-10) | Howie Mandel, Paula Marshall | N/A |
| 998 | December 11, 2009 (2009-12-11) | Jim Parsons | They Might Be Giants performs "Why Does the Sun Shine? (The Sun Is a Mass of Incandescent Gas)" |
| 999 | December 14, 2009 (2009-12-14) | Joshua Jackson, Lake Bell | Reba McEntire performs "Strange" |
| After traveling to Nashville for standup, Ferguson's flight was overbooked. He tells the story and takes the opportunity to thoroughly dress down the relevant airline. ||||
| 1,000 | December 15, 2009 (2009-12-15) | Jason Schwartzman, Maria Bello, Kristen Bell | Puppet Count Dracula (Jason Segel), performs "Dracula's Lament", accompanied by The Broken West |
| Special 1000th episode: puppet Wavy Rancheros takes over hosting duties as the puppets run the show; special musical opening dance to Trace Adkins' "Honky Tonk Badonkadonk", and closing number to James Taylor's "You've Got a Friend" in this classic episode. ||||
| 1,001 | December 16, 2009 (2009-12-16) | Bob Barker, Greta Van Susteren | N/A |
| 1,002 | December 17, 2009 (2009-12-17) | Sigourney Weaver, Hank Stuever | N/A |
| 1,003 | December 18, 2009 (2009-12-18) | Judi Dench, Michelle Rodriguez | N/A |
| 1,004 | December 21, 2009 (2009-12-21) | Special drop-in guest Betty White | Renée Fleming sings selections from composer Umberto Giordano; comedian Jim McDonald |
| 1,005 | December 22, 2009 (2009-12-22) | Kathy Griffin; Tim Meadows and Paul Schaffer perform a skit | Harry Connick Jr. performs "Christmas Day" |
| 1,006 | December 23, 2009 (2009-12-23) | Paris Hilton, José Andrés | N/A |

## 2010
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,007 | January 4, 2010 (2010-01-04) | Rosie Perez | Switchfoot performs "Always" from Hello Hurricane |
| 1,008 | January 5, 2010 (2010-01-05) | Patricia Heaton | Yonder Mountain String Band performs "Out of the Blue" from The Show |
| 1,009 | January 6, 2010 (2010-01-06) | Ray Romano, Herb Alpert | Herb Alpert and Lani Hall perform a medley from their Grammy-nominated album Anything Goes |
| 1,010 | January 7, 2010 (2010-01-07) | Comedian Steven Wright, Michelle Monaghan Kathy Griffin phones regarding the CNN New Year's Eve broadcast | Comedian Steven Wright |
| 1,011 | January 8, 2010 (2010-01-08) | Jason Segel | N/A |
| 1,012 | January 11, 2010 (2010-01-11) | Mila Kunis | Nellie McKay plays "The Very Thought of You" from Normal as Blueberry Pie – A Tribute to Doris Day |
| 1,013 | January 12, 2010 (2010-01-12) | Carey Mulligan, Paula Poundstone | Comedienne Paula Poundstone |
| 1,014 | January 13, 2010 (2010-01-13) | Comedian Richard Lewis | N/A |
| 1,015 | January 14, 2010 (2010-01-14) | Julie Andrews, Amber Valletta | Vampire Weekend with the Calder Quartet play "Horchata" from Contra |
| 1,016 | January 15, 2010 (2010-01-15) | Thomas Lennon, Shiri Appleby | Luke Bryan |
| 1,017 | January 18, 2010 (2010-01-18) | Marion Cotillard, Steve Jones | The Hotrats and Steve Jones, formerly of the Sex Pistols, play "E.M.I.", from the 1977 Never Mind the Bollocks, Here's the Sex Pistols |
| 1,018 | January 19, 2010 (2010-01-19) | Alan Alda, Anna Kendrick | N/A |
| 1,019 | January 20, 2010 (2010-01-20) | Keri Russell, Jake Johannsen | Comedian Jake Johannsen |
| 1,020 | January 21, 2010 (2010-01-21) | Adam Goldberg, Abbie Cornish | N/A |
| 1,021 | January 22, 2010 (2010-01-22) | Grant Imahara, Tory Belleci, Kari Byron | The Hotrats play "Pump It Up" |
| 1,022 | January 25, 2010 (2010-01-25) | Director, comedian, and author Carl Reiner, Alicia Witt | N/A |
| 1,023 | January 26, 2010 (2010-01-26) | Musician 50 Cent, Adrianne Palicki | N/A |
| 1,024 | January 27, 2010 (2010-01-27) | Comedian Eddie Izzard, chef Myron Mixon | N/A |
| 1,025 | January 28, 2010 (2010-01-28) | Rosie O'Donnell | Wilco |
| Cold open: Rosie O'Donnell lip syncs to Robert Palmer's "Addicted to Love" with Ferguson and company ||||
| 1,026 | January 29, 2010 (2010-01-29) | Jon Heder | Corinne Bailey Rae performs "I'd Do It All Again" from The Sea; comedienne Dana Eagle |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,027 | February 4, 2010 (2010-02-04) | Tina Brown, Chris Kattan | N/A |
| 1,028 | February 5, 2010 (2010-02-05) | Jill Scott, Claire Danes | N/A |
| 1,029 | February 9, 2010 (2010-02-09) | Pierce Brosnan, Patty Griffin | N/A |
| 1,030 | February 9, 2010 (2010-02-09) | Donald Glover, Carrie Fisher | N/A |
| Tweets are included in email segment for the first time. ||||
| 1,031 | February 10, 2010 (2010-02-10) | Gabourey Sidibe, Jeff Stilson | OK Go |
| 1,032 | February 11, 2010 (2010-02-11) | Don Rickles, Sonya Walger | N/A |
| 1,033 | February 12, 2010 (2010-02-12) | Carey Mulligan | David Nail |
| 1,034 | February 15, 2010 (2010-02-15) | Colin Firth Puppet Wavy Rancheros does the cold open | N/A |
| 1,035 | February 16, 2010 (2010-02-16) | Matt Lucas Bob Saget drops in for tweets and emails | Your Lips Your Lips perform "Never Again" |
| 1,036 | February 17, 2010 (2010-02-17) | Helena Bonham Carter Cold open skit with Jerry Springer | N/A |
| Origins of Geoff Peterson: Ferguson refers to the skull marotte created for him by the props department as his sidekick. ||||
| 1,037 | February 18, 2010 (2010-02-18) | Jennifer Tilly, Jimmie Johnson Puppet Wavy Rancheros does the cold open Josh Robert Thompson voices "'Morgan Freeman's' Guide to the Winter Olympics" | N/A |
| Origins of Geoff Peterson: Ferguson announces that he will have a robot skeleton made to be his sidekick. ||||
| 1,038 | February 19, 2010 (2010-02-19) | NPR announcer Peter Sagal, Topher Grace | N/A |
| 1,039 | February 22, 2010 (2010-02-22) | Tom Everett Scott, Parker Posey | N/A |
| 1,040 | February 23, 2010 (2010-02-23) | Stephen Fry | N/A |
| English actor, comedian, director and writer Stephen Fry is the sole guest in this special tribute to The Late Late Show with Tom Snyder, presented without the regular studio audience. ||||
| 1,041 | February 24, 2010 (2010-02-24) | Don Cheadle, Jeannette Walls Cheadle and Tim Meadows do a skit for the cold open. | N/A |
| 1,042 | February 25, 2010 (2010-02-25) | Seann William Scott, Jackie Collins Eddie Izzard drops in to read emails | N/A |
| 1,043 | February 26, 2010 (2010-02-26) | Quentin Tarantino | Mumford & Sons perform "The Cave" from Sigh No More |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,045 | March 2, 2010 (2010-03-02) | Steven Wright, Mitch Albom | Mumiy Troll performs "Polar Bear" |
| Origins of Geoff Peterson: Ferguson announces that Grant Imahara of Mythbusters got 100,000 Twitter followers, and will be building him a robot skeleton sidekick ||||
| 1,046 | March 3, 2010 (2010-03-03) | Michael Sheen, Amy Ryan | TBA |
| Michael Sheen arrives early for tweets and emails, and stays through the end of the show in a Graham Norton Show-style episode ||||
| 1,047 | March 4, 2010 (2010-03-04) | Jeffrey Tambor, Sonya Walger | Regina Spektor performs "The Calculation" from Far |
| 1,048 | March 5, 2010 (2010-03-05) | Dax Shepard, Paula Deen | TBA |
| 1,049 | March 8, 2010 (2010-03-08) | Isaac Mizrahi | Miranda Lambert performs "White Liar" from Revolution |
| 1,050 | March 9, 2010 (2010-03-09) | Lisa Kudrow, Adhir Kalyan | TBA |
| Origins of Geoff Peterson: Ferguson narrates a brief comedic history of late night, including Grant Imahara's beginning to build robot skeleton sidekick Geoff Peterson ||||
| 1,051 | March 10, 2010 (2010-03-10) | Dominic Monaghan, Lindsay Sloane | The Temper Trap performs "Sweet Disposition", featured in the soundtrack to 500 Days of Summer |
| 1,052 | March 11, 2010 (2010-03-11) | Lisa Kudrow Eddie Izzard drops in for emails and tweets | TBA |
| 1,053 | March 12, 2010 (2010-03-12) | George Hamilton Astronaut Mike Massimino | TBA |
| 1,054 | March 22, 2010 (2010-03-22) | John Cusack, Lana Parrilla | TBA |
| 1,055 | March 23, 2010 (2010-03-23) | Jay Baruchel, Regis Philbin | Regis and Joy Philbin sing "Two Sleepy People" |
| 1,056 | March 24, 2010 (2010-03-24) | Jonah Hill, Emily Procter | TBA |
| 1,057 | March 29, 2010 (2010-03-29) | Joel McHale Steve Jones formerly of the Sex Pistols does a comedy skit | TBA |
| 1,058 | March 30, 2010 (2010-03-30) | Ben McKenzie Ferguson, Chunky B and Bradley Laise do a (Prince) "Charles!" skit | V V Brown sings "Shark in the Water" from Travelling Like the Light |
| Origins of Geoff Peterson: Clip of Grant Imahara's progress on robot skeleton sidekick Geoff Peterson ||||
| 1,059 | March 31, 2010 (2010-03-31) | Wanda Sykes | TBA |
| In the cold open, puppet Wavy Rancheros announces The Late Late Show has won a Peabody Award for the March 4, 2009 episode with Archbishop Desmond Tutu ||||

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,060 | April 1, 2010 (2010-04-01) | Robin Williams Philosopher Jonathan Dancy | N/A |
| 1,061 | April 2, 2010 (2010-04-02) | John Corbett, Joss Stone | Joss Stone and Jamie Hartman perform "Stalemate" from Battling Giants |
| 1,062 | April 5, 2010 (2010-04-05) | Kristen Bell, Grant Imahara | N/A |
| Musical cold open: lip sync to "Look Out There's a Monster Coming" by the Bonzo Dog Doo-Dah Band for the debut of robot skeleton sidekick Geoff Peterson. Created by guest Grant Imahara of The Mythbusters, Geoff will become a permanent character on the show. He is initially voiced with a recorded robotic version of Ferguson's voice. ||||
| 1,063 | April 6, 2010 (2010-04-06) | Mindy Kaling, Dom Irrera | Comedian Dom Irrera |
| 1,064 | April 7, 2010 (2010-04-07) | Raquel Welch, Anna Torv Michael Clark Duncan reads from Jennifer Love Hewitt's book, The Day I Shot Cupid | N/A |
| 1,065 | April 8, 2010 (2010-04-08) | Jennifer Love Hewitt Stuart Neville author of The Ghosts of Belfast | N/A |
| 1,066 | April 9, 2010 (2010-04-09) | Kunal Nayyar Betty White drops in for a comedy bit Outtakes of Michael Clarke Duncan | Slash performs "By the Sword" from his self-titled album, featuring vocalist Andrew Stockdale |
| Close: Ferguson discusses Geoff Peterson as an allegory ||||
| 1,067 | April 12, 2010 (2010-04-12) | Tim Gunn; former Drew Carey Show costar Kathy Kinney | N/A |
| 1,068 | April 13, 2010 (2010-04-13) | James Marsden, Charlyne Yi | N/A |
| Cold open with chicken puppet "Agatha" and pig puppet "Gustave Flaubert" ||||
| 1,069 | April 14, 2010 (2010-04-14) | Andie MacDowell IndyCar driver Dario Franchitti | Dawes performs "When My Time Comes" from North Hills |
| 1,070 | April 15, 2010 (2010-04-15) | Kirstie Alley | Sade |
| 1,071 | April 16, 2010 (2010-04-16) | Willie Nelson, Ellie Kemper | Willie Nelson performs "Man With the Blues" from 2010's Country Music, originally recorded in 1959. |
| 1,072 | April 19, 2010 (2010-04-19) | Brendan Fraser, Amanda Righetti Gardening Tips with Willie Nelson skit | Comedian Brian Scott McFadden |
| 1,073 | April 20, 2010 (2010-04-20) | Emily Mortimer Gardening Tips with Willie Nelson skit | Comedian Randy Kagan Miranda Lambert performs "The House That Built Me" from Revolution |
| 1,074 | April 21, 2010 (2010-04-21) | Brooke Shields, George Wallace | Corinne Bailey Rae performs "Closer" from The Sea |
| 1,075 | April 22, 2010 (2010-04-22) | Jeffrey Dean Morgan, Busy Philipps Gardening Tips with Willie Nelson skit | N/A |
| 1,076 | April 23, 2010 (2010-04-23) | Drew Carey Gardening Tips with Willie Nelson skit | Jason Aldean performs "Crazy Town" from Wide Open |
| 1,077 | April 29, 2010 (2010-04-29) | Tom Selleck, Lance Burton | Magician Lance Burton is introduced by Neil Patrick Harris |
| 1,078 | April 30, 2010 (2010-04-30) | NPR broadcaster Peter Sagal Lauren Graham drops by to read emails Style tips with Tim Gunn, 80's edition Gardening tips with Willie Nelson | N/A |

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,079 | May 3, 2010 | Morgan Freeman, Kate Mara Gardening Tips with Willie Nelson skit | |
| 1,080 | May 4, 2010 | Andy García, Donald Glover | |
| 1,081 | May 5, 2010 | Scarlett Johansson | |
| 1,082 | May 6, 2010 | Mark Harmon, Sophia Bush | Local Natives performs "Airplanes" from Gorilla Manor |
| 1,083 | May 7, 2010 | Seth MacFarlane Steven Wright drops in for tweets and emails | Comedian Matt Baetz |
| 1,084 | May 10, 2010 | Russell Crowe Style Tips with Tim Gunn '80s Edition | Wilco performs "Deeper Down" from Wilco (The Album) |
| 1,085 | May 11, 2010 | Melina Kanakaredes, Tom Lennon | Jónsi (of Sigur Rós) performs "Go Do" from Go |
| 1,086 | May 12, 2010 | Bryan Cranston, Angela Kinsey Gardening Tips with Willie Nelson | |
| 1,087 | May 13, 2010 | Robert Downey Jr. Gardening Tips with Willie Nelson | |
| 1,088 | May 14, 2010 | Amanda Seyfried, Isabel Allende Style Tips with Tim Gunn '80s Edition Gardening Tips with Willie Nelson | |
| 1,089 | May 18, 2010 | Jon Favreau | Jakob Dylan performs "Nothing But the Whole Wide World" from Women + Country |
| 1,090 | May 19, 2010 | Dennis Quaid, Alice Eve Donald Glover drops in for tweets and emails | |
| 1,091 | May 20, 2010 | Holly Hunter Style Tips with Tim Gunn 80's Edition | The Hold Steady perform "Rock Problems" from Heaven is Whenever |
| 1,092 | May 21, 2010 | Ben Kingsley | Court Yard Hounds (a side project of Martie Maguire and Emily Strayer of The Chicks (formerly The Dixie Chicks)) perform "The Coast" from Court Yard Hounds |
| 1,093 | May 24, 2010 | Ben Stein | Mishka performs "Bittersweet" from Talk About Comedian Craig Shoemaker |
| 1,094 | May 25, 2010 | Kristin Davis, Judd Apatow Style tips with Tim Gunn 80's Edition The show's closing ("What Did We Learn on the Show Tonight, Craig?") features the first appearance of the rabbit puppet to become known as "Sid the Cussing Bunny". | |
| 1,095 | May 26, 2010 | Antonio Banderas, Paula Poundstone | |
| 1,096 | May 27, 2010 | Michael Sheen First cold open appearance of "Sid the Cussing Bunny" | Band of Horses performs "Compliments" from Infinite Arms |
| 1,097 | May 28, 2010 | Shirley Manson, Jeffrey Ross | The National performs "Anyone's Ghost" from High Violet |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,098 | June 2, 2010 (2010-06-02) | Evangeline Lilly, Charlyne Yi | Magicians Larry and Rafael |
| 1,099 | June 3, 2010 (2010-06-03) | Adam Goldberg | Magician Jamy Ian Smith |
| 1,100 | June 4, 2010 (2010-06-04) | Jennifer Tilly ESPN UK skit with Ferguson, Philip McGrade and Ben Kingsley Gardening Tips with Willie Nelson | Magician Ed Alonzo |
| 1,101 | June 7, 2010 (2010-06-07) | Eric Idle, Terry Crews | TBA |
| 1,102 | June 8, 2010 (2010-06-08) | John Waters, Taraji P. Henson Cold open: skit with Ferguson, John Waters and Bradley Laise | TBA |
| 1,103 | June 9, 2010 (2010-06-09) | Kyra Sedgwick, Tom Felton Cold open: Ferguson's suit is not ready. | TBA |
| 1,104 | June 10, 2010 (2010-06-10) | Chef Wolfgang Puck Ferguson and NBC's Jimmy Fallon call a late night truce and wave from their respective shows with a large Mickey Mouse glove | Damian Marley and Nas perform "As We Enter" from Distant Relatives |
| 1,105 | June 11, 2010 (2010-06-11) | Denis Leary | Comedian John "Hippieman" Novosad |
| 1,106 | June 14, 2010 (2010-06-14) | Bradley Whitford | Shelby Lynne, Comedian Jeff Stilson |
| 1,106 | June 15, 2010 (2010-06-15) | Ice Cube, Stan Lee | Comedienne Tig Notaro |
| 1,107 | June 16, 2010 (2010-06-16) | Tim Allen Josh Robert Thompson voices "Morgan Freeman's Guide to the World Cup" | TBA |
| 1,108 | June 17, 2010 (2010-06-17) | Virginia Madsen, Chris Hardwick | Justin Currie of Del Amitri, Glaswegian friend of Ferguson, performs "You'll Always Walk Alone" from The Great War |
| 1,109 | June 18, 2010 (2010-06-18) | Mark Ruffalo, Saffron Burrows | TBA |
| 1,110 | June 21, 2010 (2010-06-21) | Maria Bello, DJ Qualls | TBA |
| 1,111 | June 22, 2010 (2010-06-22) | Valerie Bertinelli, Jerry Ferrara | TBA |
| 1,112 | June 23, 2010 (2010-06-23) | Julia Ormond, José Andrés | TBA |
| 1,100 | June 4, 2010 (2010-06-04) | Lisa Kudrow, James Dyson | Robert David Hall performs the title track from Things They Don't Teach You In School |
| 1,114 | June 25, 2010 (2010-06-25) | Tim Meadows, Jean-Michel Cousteau | TBA |
| 1,115 | June 28, 2010 (2010-06-28) | Howie Mandel, Jane Adams | TBA |
| 1,116 | June 29, 2010 (2010-06-29) | Carl Reiner, Rebecca Mader | Sharon Jones & the Dap-Kings |
| 1,117 | June 30, 2010 (2010-06-30) | Mindy Kaling, Chef Myron Mixon | TBA |

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,118 | July 1, 2010 | Kathy Griffin, Michael Vartan | Alicia Witt |
| 1,119 | July 2, 2010 | Dennis Eckersley | Dr. Dog |
| 1,120 | July 12, 2010 | Julie Chen, Michael Ian Black | Dierks Bentley |
| 1,121 | July 13, 2010 | Marion Cotillard | Louie Anderson |
| 1,122 | July 14, 2010 | Alfred Molina, Cathy Ladman | |
| 1,123 | July 15, 2010 | Nicolas Cage | Marina and the Diamonds |
| 1,124 | July 16, 2010 | Elliot Page | |
| 1,125 | July 19, 2010 | Jeffrey Dean Morgan, Mary Lynn Rajskub | |
| 1,126 | July 20, 2010 | America Ferrera, Dan Riskin | |
| 1,127 | July 21, 2010 | Ted Danson, Kevin Pollak | |
| 1,128 | July 22, 2010 | Michael Clarke Duncan, Daniela Ruah | |
| 1,129 | July 23, 2010 | Paulina Porizkova | MGMT |
| 1,130 | July 26, 2010 | Steve Carell | She & Him |
| 1,131 | July 27, 2010 | Morgan Freeman | The Black Keys |
| 1,132 | July 28, 2010 | Carrie Fisher, Ron Livingston | |
| 1,133 | July 29, 2010 | Neil Patrick Harris, Dr. Sanjay Gupta | |
| 1,134 | July 30, 2010 | Mary Lynn Rajskub, Christopher Gorham |

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,135 | August 2, 2010 | George Hamilton | Comedian Fred MacAulay |
| 1,136 | August 3, 2010 | Jeffrey Tambor | Drew Thomas |
| 1,137 | August 4, 2010 | Julie Chen, Paula Poundstone | Comedian Paula Poundstone |
| 1,138 | August 5, 2010 | Paris Hilton, Alex Dryden | |
| 1,139 | August 6, 2010 | Mark Wahlberg, Jacinda Barrett | |
| 1,140 | August 9, 2010 | Lindsay Sloane | Vampire Weekend |
| 1,141 | August 10, 2010 | David Duchovny, Dave Barry | |
| 1,142 | August 11, 2010 | Maggie Gyllenhaal Betty White drops in for a comedy bit | |
| 1,143 | August 12, 2010 | Emma Thompson | Comedian Carlos Alazraqui |
| 1,144 | August 13, 2010 | Anna Kendrick Chris Hardwick drops in for tweets and emails; "Murder She Wrote" skit with Alfred Molina | |
| 1,145 | August 30, 2010 | Adam Goldberg | Chief perform "Night and Day" from Modern Rituals |
| 1,146 | August 31, 2010 | Don Johnson, Laura Lippman James Lipton appears in cold open skit | |

### September

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,147 | September 1, 2010 | Rachael Ray, William Knoedelseder, author of I'm Dying Up Here: Heartbreak and High Times in Standup Comedy's Golden Age | |
| 1,148 | September 2, 2010 | Billy Gardell Chris Hardwick drops in for tweets and emails | Sara Watkins performs "Where Will You Be?" from her self-titled album |
| 1,149 | September 3, 2010 | Brooke Shields DJ Qualls drops in for tweets and emails | |
| 1,150 | September 6, 2010 | John Larroquette, Malin Åkerman Cold open with both Sid the Cussing Bunny and Wavy Rancheros simultaneously puppeteered by Ferguson | |
| 1,151 | September 7, 2010 | Chris Kattan, Rob Stewart | |
| 1,152 | September 8, 2010 | James Lipton, Monica Potter | |
| 1,153 | September 9, 2010 | Rashida Jones, Dr. Mehmet Oz | Blake Shelton performs the title track from All About Tonight |
| 1,154 | September 10, 2010 | Donald Glover, Katey Sagal | Norah Jones performs "Man of the Hour" from The Fall |
| 1,155 | September 13, 2010 | Philip Seymour Hoffman | |
| 1,156 | September 14, 2010 | Kristen Bell | Sarah McLachlan performs "Forgiveness" from Laws of Illusion |
| 1,157 | September 15, 2010 | Don Rickles, Ellie Kemper | |
| 1,158 | September 16, 2010 | William Shatner Shatner and Ferguson do a bit in the cold open and get physical during the interview | |
| 1,159 | September 17, 2010 | Tim Gunn, Jennifer Finnigan | |
| 1,160 | September 20, 2010 | Mindy Kaling, broadcast journalist Steve Hartman | |
| 1,161 | September 21, 2010 | Patricia Heaton, Adam Brody | Sara Bareilles performs "King of Everything" from Kaleidoscope Heart |
| 1,162 | September 22, 2010 | Johnny Galecki, Jim Parsons, Kaley Cuoco and Simon Helberg from The Big Bang Theory | |
| 1,163 | September 23, 2010 | Jon Hamm; Jonathan Ames, creator of Bored to Death Betty White drops in for a comedy bit | |
| 1,164 | September 24, 2010 | John Schwartzman Schwartzman and Betty White appear in a skit Ferguson announces he will voice Owl in the new animated 2011 film Winnie the Pooh Geoff Peterson does a remote spot at the premiere of You Again | Willie Nelson performs "Freight Train Boogie" |
| 1,165 | September 27, 2010 | Sela Ward, Guillermo del Toro |
| 1,166 | September 28, 2010 | David Boreanaz, Melissa McCarthy | |
| 1,167 | September 29, 2010 | Steven Wright, Sloane Crosley Wright briefly plays the harmonica with Ferguson and discusses working without a net | Blake Shelton performs "Who Are You When I'm Not Looking" from All About Tonight |
| 1,168 | September 30, 2010 | Edward Norton, Odette Yustman |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,169 | October 1, 2010 (2010-10-01) | Carey Mulligan | Comedian Marc Maron |
| 1,170 | October 4, 2010 (2010-10-04) | Lauren Graham | Rosanne Cash |
| 1,171 | October 5, 2010 (2010-10-05) | Alfred Molina | Comedienne Cory Kahaney |
| Musical cold open: Mythbusters Adam Savage and Jamie Hyneman join Ferguson, Wavy, Sid and company to lip sync to "I Melt With You" by Modern English; Chris Hardwick drops in for "tweetmails" ||||
| 1,172 | October 6, 2010 (2010-10-06) | Debra Winger, Adhir Kalyan | Julie Gribble performs the title track from her album Letting Go |
| 1,173 | October 7, 2010 (2010-10-07) | Toby Keith, Louie Anderson | Comedian Louie Anderson Toby Keith performs the title track from Bullets in the Gun |
| 1,174 | October 8, 2010 (2010-10-08) | Mary Lynn Rajskub NASCAR driver Carl Edwards | N/A |
| Pantomime horse "Secretariat" makes his first appearance in a parody of the trailer for the film Secretariat ||||
| 1,175 | October 11, 2010 (2010-10-11) | John Malkovich | N/A |
| Pantomime horse Secretariat, who will become a regular on the show, makes his first live appearance. He will appear frequently on the show, and in the fall of 2012 become a permanent "cast member". ||||
| 1,176 | October 12, 2010 (2010-10-12) | Trace Adkins, astronomer Derrick Pitts | Trace Adkins performs "This Ain't No Love Song" from Cowboy's Back in Town |
| Secretariat makes his second appearance and has trouble finding the door ||||
| 1,177 | October 13, 2010 (2010-10-13) | Minnie Driver, Diedrich Bader | N/A |
| 1,178 | October 14, 2010 (2010-10-14) | Drew Carey, Jenny Wade | N/A |
| Remote segment of Geoff Peterson, "live", voiced ad-lib by Josh Robert Thompson at the premiere of the movie Red. There he chats briefly with Morgan Freeman, Richard Dreyfus, John Malkovich, Mary Louise Parker, Red director Taylor Hackford, Sylvester Stallone and Bruce Willis ||||
| 1,179 | October 15, 2010 (2010-10-15) | Julie Chen, Ty Burrell | Billy Currington performs "Pretty Good at Drinkin' Beer" from Enjoy Yourself |
| 1,180 | October 25, 2010 (2010-10-25) | Condoleezza Rice, Joe Theismann | N/A |
| 1,181 | October 26, 2010 (2010-10-26) | Danny DeVito, Brie Larson | Comedian Henry Cho |
| DeVito appears in the cold open skit ||||
| 1,182 | October 27, 2010 (2010-10-27) | Marg Helgenberger, Donald Glover | N/A |
| 1,183 | October 28, 2010 (2010-10-28) | Michael Caine | N/A |
| Closing segment: Ferguson reflects on his journey from youthful misadventures to hosting a chat show with Sir Michael Caine as a guest. ||||
| 1,184 | October 29, 2010 (2010-10-29) | Jason Segel, Alison Brie | Comedian Adam Hills |
| Musical cold open: Halloween lip sync by Ferguson, puppets and company to Bobby "Boris" Pickett's "Monster Mash" ||||

### November

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,185 | November 1, 2010 | Tyler Perry, Sophia Bush | |
| 1,186 | November 3, 2010 | Lewis Black, Jayma Mays | Dr. Dog |
| 1,187 | November 4, 2010 | Dick Van Dyke, Kerry Washington Cold Open: Samuel L. Jackson with Craig outside Dick Van Dyke's dressing room. | |
| 1,188 | November 5, 2010 | Juliette Lewis, Cornel West | |
| 1,189 | November 8, 2010 | Tom Selleck | Myq Kaplan |
| 1,190 | November 9, 2010 | Cheryl Hines, Wolfgang Puck | |
| 1,191 | November 10, 2010 | Tim Meadows, Stan Lee | |
| 1,192 | November 11, 2010 | Rosie Perez, Quinton Jackson | |
| 1,193 | November 12, 2010 | Carrie Ann Inaba | Bettye LaVette |
| 1,194 | November 15, 2010 | Dennis Miller, Bianca Kajlich | |
| 1,195 | November 16, 2010 | Chris Hardwick, Matt Smith | |
| 1,196 | November 17, 2010 | Russell Crowe | |
| 1,197 | November 18, 2010 | Jeff Goldblum | |
| 1,198 | November 19, 2010 | Amy Sedaris, Adam Savage, Jamie Hyneman | |
| 1,199 | November 22, 2010 | Ben Stein, Dr. Lisa Masterson | The Very Best |
| 1,200 | November 23, 2010 | Mark Ruffalo, Kathryn Hahn | |
| 1,201 | November 24, 2010 | Dwayne Johnson, Paula Deen | |
| 1,202 | November 29, 2010 | Michael Sheen | |
| 1,203 | November 30, 2010 | DJ Qualls, Salman Rushdie |

### December

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,204 | December 1, 2010 | Regis Philbin | Wendy Liebman |
| 1,205 | December 2, 2010 | Cedric the Entertainer, Chris Hardwick | Norah Jones |
| 1,206 | December 3, 2010 | Kristen Bell | Michael Franti and Spearhead |
| 1,207 | December 6, 2010 | Katie Couric | Al Madrigal |
| 1,208 | December 7, 2010 | Carrie Fisher, Dennis Lehane | |
| 1,209 | December 8, 2010 | Russell Brand, Richard Wolffe | |
| 1,210 | December 9, 2010 | Lucy Liu, Jody Williams | |
| 1,211 | December 10, 2010 | Neil Patrick Harris | Nellie McKay |
| 1,212 | December 13, 2010 | Tom Arnold, Alison Becker | |
| 1,213 | December 14, 2010 | Kirsten Dunst | Greg Proops |
| 1,214 | December 15, 2010 | Nick Lachey | Jamy Ian Swiss |
| 1,215 | December 16, 2010 | Seth Green, Lena Dunham | |
| 1,216 | December 17, 2010 | Billy Connolly, Maria Bamford Billy Connolly is awarded the first-ever "Golden Mouth Organ" | |
| 1,217 | December 20, 2010 | Kristin Davis, Dick Cavett | |
| 1,218 | December 21, 2010 | Jane Fonda, Grant Imahara | |
| 1,219 | December 22, 2010 | Michael Clarke Duncan, Grant Imahara | |
| 1,220 | December 23, 2010 | Kathy Griffin | Ruth Gerson |

## 2011
### January

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,223 | January 3, 2011 | Lisa Kudrow | Matt Braunger |
| 1,224 | January 4, 2011 | Julie Bowen, Carson Kressley | |
| 1,225 | January 5, 2011 | Henry Winkler, Paula Deen | |
| 1,226 | January 6, 2011 | Gary Sinise, Alex Kingston | |
| 1,227 | January 7, 2011 | Mila Kunis | Geechy Guy |
| 1,228 | January 10, 2011 | Roseanne Barr, Joe Theismann, Tuyen & Lisa in the cold open | |
| 1,229 | January 11, 2011 | Paula Abdul | Dave Attell |
| 1,230 | January 12, 2011 | David Duchovny, Jo Frost | |
| 1,231 | January 13, 2011 | Denis Leary | Kathleen Madigan |
| 1,232 | January 14, 2011 | Paul Giamatti, Piper Perabo | |
| 1,233 | January 17, 2011 | Rashida Jones, Tony Goldwyn | |
| 1,234 | January 18, 2011 | Larry King, Shannon Woodward | |
| 1,235 | January 19, 2011 | Emily Deschanel | Rich Fulcher |
| 1,236 | January 20, 2011 | Maria Bello, Dan Riskin | |
| 1,237 | January 21, 2011 | Jeff Bridges, Melissa Rauch | |
| 1,238 | January 24, 2011 | Valerie Bertinelli, Pau Gasol | |
| 1,239 | January 25, 2011 | Jennifer Love Hewitt, Jon Lovitz | |
| 1,240 | January 26, 2011 | Betty White, Ellie Kemper | |
| 1,241 | January 27, 2011 | Adam Goldberg, Shannon Woodward | |
| 1,242 | January 28, 2011 | Helena Bonham Carter | Larry Gatlin and the Gatlin Brothers |
| 1,243 | January 31, 2011 | Rachael Ray | |

### February

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,244 | February 1, 2011 | Cornel West | George Clinton and P-Funk |
| 1,245 | February 2, 2011 | Jim Parsons | |
| 1,246 | February 3, 2011 | Matt LeBlanc, David Pogue | |
| 1,247 | February 4, 2011 | Matt Lucas | |
| 1,248 | February 7, 2011 | Gabrielle Union | Kurt Metzger |
| 1,249 | February 8, 2011 | Emily Blunt, Kara Cooney | |
| 1,250 | February 9, 2011 | Carl Reiner, Cat Cora | |
| 1,251 | February 10, 2011 | Jennifer Beals, Jean-Michel Cousteau | |
| 1,252 | February 11, 2011 | Jason Biggs, Jennifer Ouellette | |
| 1,253 | February 14, 2011 | Bob Barker, Melissa Rauch | |
| 1,254 | February 15, 2011 | William Shatner, Gillian Jacobs | |
| 1,255 | February 16, 2011 | Joely Fisher | Matt Kirshen |
| 1,256 | February 17, 2011 | Sarah Chalke | Louie Anderson |
| 1,257 | February 18, 2011 | DJ Qualls, Lily Tomlin | |
| 1,258 | February 21, 2011 | Wolf Blitzer, Sara Rue | |
| 1,259 | February 22, 2011 | John Waters | |
| 1,260 | February 23, 2011 | Joel McHale | Comedian Greg Warren |
| 1,261 | February 24, 2011 | Forest Whitaker, Teresa Palmer | |
| 1,262 | February 25, 2011 | Malin Åkerman, Phil Keoghan | |
| 1,263 | February 28, 2011 | Isaac Mizrahi, Patton Oswalt Chris Hardwick drops in for tweetmails and a clip of his and Bridger Winegar's visit to the Dr. Who convention | |

### March

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,264 | March 1, 2011 | Carla Gugino, Tom Lennon | |
| 1,265 | March 2, 2011 | Hugh Laurie, Ariel Tweto | |
| 1,266 | March 3, 2011 | Neil Patrick Harris | Tomorrows Bad Seeds |
| 1,267 | March 4, 2011 | Kathy Griffin, Wendy Booker | |
| 1,268 | March 7, 2011 | Aaron Eckhart, Paula Poundstone | |
| 1,269 | March 8, 2011 | Topher Grace, Catherine Deneuve | |
| 1,270 | March 9, 2011 | Trace Adkins, Windell Middlebrooks | |
| 1,271 | March 10, 2011 | Wanda Sykes, Kevin McKidd | |
| 1,272 | March 11, 2011 | Amanda Peet, Phil Hanley |
| 1,273 | March 14, 2011 | Lewis Black | Stackridge |
| 1,274 | March 15, 2011 | Martha Stewart | |
| 1,275 | March 16, 2011 | Seth Rogen, Brie Larson | |
| 1,276 | March 28, 2011 | Bob Geldof | Far East Movement |
| 1,277 | March 29, 2011 | Larry King, Dr. Sanjay Gupta | |
| 1,278 | March 30, 2011 | Matthew McConaughey, Amy Smart | |
| 1,279 | March 31, 2011 | Julie Chen, Jeffrey Tambor | |

### April

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,280 | April 1, 2011 | Paul Giamatti, Casey Wilson | |
| 1,281 | April 4, 2011 | D. L. Hughley, Michelle Monaghan | |
| 1,282 | April 5, 2011 | Jerry O'Connell, Sophia Bush | |
| 1,283 | April 6, 2011 | Elliot Page | Marc Maron |
| 1,284 | April 7, 2011 | Helen Hunt, Billy Gardell | |
| 1,285 | April 8, 2011 | Zooey Deschanel, Chris Hardwick | |
| 1,286 | April 11, 2011 | Isabella Rossellini, Casey Wilson | |
| 1,287 | April 12, 2011 | Wynonna Judd, Ariel Tweto | |
| 1,288 | April 13, 2011 | Ashley Judd, Evan Michelson | Maz Jobrani |
| 1,289 | April 14, 2011 | Kristen Bell, Jason Aldean | |
| 1,290 | April 15, 2011 | Robin Wright, Dan Riskin | |
| 1,291 | April 18, 2011 | Tina Fey, Joe DeVito | Everest |
| 1,292 | April 19, 2011 | Kathy Griffin, Derrick Pitts | |
| 1,293 | April 20, 2011 | Michael Clarke Duncan, Lena Headey | |
| 1,294 | April 21, 2011 | Alfred Molina | Joe DeVito |
| 1,295 | April 22, 2011 | Diane Lane, Karen Gillan | |
| 1,296 | April 28, 2011 | Tom Selleck, Odette Annable | |
| 1,297 | April 29, 2011 | Bob Saget | Sharon Jones & the Dap-Kings |

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,298 | May 2, 2011 | Mindy Kaling, Matt Lucas | |
| 1,299 | May 3, 2011 | Geoffrey Rush | OK Go |
| 1,300 | May 4, 2011 | John Waters, Pauley Perrette | |
| 1,301 | May 5, 2011 | Juliette Lewis, Phil Rosenthal | |
| 1,302 | May 6, 2011 | Will Ferrell | Reese Waters |
| 1,303 | May 9, 2011 | Jeff Goldblum, Sarah Chalke | |
| 1,304 | May 10, 2011 | Kenneth Branagh, Edward Conlon | |
| 1,305 | May 11, 2011 | Tim Meadows, Colin Hay | |
| 1,306 | May 12, 2011 | Mary Lynn Rajskub, Lawrence Block | Tim Minchin |
| 1,307 | May 13, 2011 | Paul Reiser, Melissa McCarthy | |
| 1,308 | May 16, 2011 | Simon Helberg, Sidekick/gay skeleton robot Geoff Peterson | |
| 1,309 | May 17, 2011 | Patton Oswalt Betty White drops in for a comedy bit | |
| 1,310 | May 18, 2011 | Julie Andrews brings a special set of pajamas for Craig to wear during their chat | Little Big Town perform the title track from their album The Reason Why |
| 1,311 | May 19, 2011 | Tony Shalhoub, Sloane Crosley Skeleton robot Geoff Peterson, ad lib voiced by Josh Robert Thompson, tells about a few places he has, earning a permanent place at TLLS. | |
| 1,312 | May 20, 2011 | Carrie Fisher, Edward Conlon | |
| 1,313 | May 23, 2011 | Jack Black, Quinton Jackson | |
| 1,314 | May 24, 2011 | Courteney Cox, Carrot Top | Comedian Carrot Top |
| 1,315 | May 25, 2011 | Norm Macdonald, Julie McCarthy | Oh Land performs "Sun(sic) of a Gun" from Oh Land |
| 1,316 | May 26, 2011 | Seth Green Magician Lance Burton | |
| 1,317 | May 27, 2011 | Drew Carey, Rutina Wesley | Electric Barbarellas perform "Without You" from Strange World |
| 1,318 | May 30, 2011 | Adam Goldberg, Lucy Punch | |
| 1,319 | May 31, 2011 | Ray Romano, Dr. Lisa Masterson from The Doctors | |

### June

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,320 | June 1, 2011 | David Beckham, Shohreh Aghdashloo | |
| 1,321 | June 2, 2011 | Dick Van Dyke, Kristin Gore | |
| 1,322 | June 3, 2011 | Carla Gugino, Rebel Wilson | |
| 1,323 | June 6, 2011 | Don Cheadle, Brooklyn Decker | |
| 1,324 | June 7, 2011 | Howie Mandel, Wendy Booker | The Goldberg Sisters |
| 1,325 | June 8, 2011 | Heather Graham, Chris Gorham | |
| 1,326 | June 9, 2011 | Morgan Freeman, Carson Kressley | |
| 1,327 | June 10, 2011 | Kevin Bacon, Wendy Williams | |
| 1,328 | June 27, 2011 | Dennis Miller, Melissa Joan Hart | |
| 1,329 | June 28, 2011 | Paris Hilton, Neil Gaiman | |
| 1,330 | June 29, 2011 | Mary-Louise Parker | Dom Irrera |
| 1,331 | June 30, 2011 | Henry Winkler, Mike Massimino | |

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,332 | July 1, 2011 | Cedric the Entertainer, Moon Bloodgood | |
| 1,333 | July 5, 2011 | Steven Wright, Ellie Kemper, Adam Savage | |
| 1,334 | July 6, 2011 | Rosie Perez | |
| 1,335 | July 7, 2011 | Thomas Lennon, Tatum O'Neal | |
| 1,336 | July 8, 2011 | Larry King | Ziggy Marley |
| 1,337 | July 11, 2011 | Elijah Wood, Cat Deeley | |
| 1,338 | July 12, 2011 | Joely Fisher, Chris Hardwick | Joss Stone |
| 1,339 | July 13, 2011 | DJ Qualls, Angela Kinsey | |
| 1,340 | July 14, 2011 | Zooey Deschanel, Jim Cummings | |
| 1,341 | July 15, 2011 | Tim Daly, Leslie Bibb | Foster the People |
| 1,342 | July 18, 2011 | Elizabeth Banks, Rich Fulcher | |
| 1,343 | July 19, 2011 | Eddie Izzard, Hayley Atwell | |
| 1,344 | July 20, 2011 | Jenna Elfman, Breckin Meyer | Omid Djalili |
| 1,345 | July 21, 2011 | Amos Lee, Bryan Cranston | |
| 1,346 | July 22, 2011 | John Goodman, Jayma Mays | |
| 1,347 | July 25, 2011 | Don Rickles | |
| 1,348 | July 26, 2011 | William H. Macy, Karen Gillan | |
| 1,349 | July 27, 2011 | Mary McCormack, David Feherty | |
| 1,350 | July 28, 2011 | Lisa Kudrow, Ben Mezrich | |
| 1,351 | July 29, 2011 | Tim Gunn, Matt Smith | Ted Alexandro |

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| Le Late Late Show avec Craig Ferguson a Paris ||||
| 1,352 | August 1, 2011 | Kristen Bell | |
| 1,353 | August 2, 2011 | Kristen Bell, Eddie Izzard, Jean Reno | |
| 1,354 | August 3, 2011 | Jean-Michel Cousteau, Kristen Bell, Jean Reno, Matt Smith | |
| 1,355 | August 4, 2011 | Kristen Bell, Jean Reno | |
| 1,356 | August 5, 2011 | Moulin Rouge | |
| 1,357 | August 22, 2011 | Hugh Laurie, Saffron Burrows | |
| 1,358 | August 23, 2011 | Lewis Black | Amos Lee |
| 1,359 | August 24, 2011 | Regis Philbin | Marina Franklin |
| 1,360 | August 25, 2011 | Kal Penn, Alice Eve | |
| 1,361 | August 26, 2011 | Shirley Manson, Tory Belleci | |
| 1,362 | August 29, 2011 | William Shatner, Bianca Kajlich | |
| 1,363 | August 30, 2011 | Chi McBride, Ariel Tweto | |
| 1,364 | August 31, 2011 | Leslie Bibb | Louie Anderson |

### September

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,365 | September 1, 2011 | Kathy Griffin, Lynette Rice | Lenka |
| 1,366 | September 2, 2011 | Lindsay Sloane, Peter Krause | |
| 1,367 | September 5, 2011 | Julie Chen, Annie Duke | |
| 1,368 | September 6, 2011 | Lisa Kudrow, Richard Engel | |
| 1,369 | September 7, 2011 | James Marsden, Wolfgang Puck | |
| 1,370 | September 8, 2011 | Tim Meadows, Bill Bailey | |
| 1,371 | September 9, 2011 | Alfred Molina, Brie Larson | |
| 1,372 | September 13, 2011 | Lauren Graham | |
| 1,373 | September 14, 2011 | Danny DeVito, Olivia Munn | Moulin Rouge |
| 1,374 | September 15, 2011 | Sigourney Weaver, Ted Alexandro | |
| 1,375 | September 16, 2011 | James Woods | |
| 1,376 | September 19, 2011 | Keith Olbermann, Kelly Macdonald | |
| 1,377 | September 20, 2011 | Harry Connick Jr., Kathryn Hahn | |
| 1,378 | September 21, 2011 | James Spader, Juno Temple | |
| 1,379 | September 22, 2011 | Chris Hardwick, Billy Gardell | |
| 1,380 | September 23, 2011 | Gerard Butler, Kat Dennings | |
| 1,381 | September 26, 2011 | Jonah Hill | Chris Young |
| 1,382 | September 27, 2011 | Mary Lynn Rajskub, Jackie Collins | Trombone Shorty |
| 1,383 | September 28, 2011 | Rashida Jones, Jonathan Ames | |
| 1,384 | September 29, 2011 | Carson Kressley, Michelle Monaghan | |
| 1,385 | September 30, 2011 | Seth Rogen, Judy Greer |

### October

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,386 | October 3, 2011 | Lily Tomlin, Ioan Gruffudd | |
| 1,387 | October 4, 2011 | Jessica Lange, Jacques Steinberg | |
| 1,388 | October 5, 2011 | Joel McHale, Elizabeth Cook | |
| 1,389 | October 6, 2011 | Evangeline Lilly, Dan Riskin | |
| 1,390 | October 7, 2011 | Jason Schwartzman, Eliza Coupe | |
| 1,391 | October 10, 2011 | Claire Danes | |
| 1,392 | October 11, 2011 | Steven Wright, Monica Potter | |
| 1,393 | October 12, 2011 | Jim Parsons | Cake |
| 1,394 | October 13, 2011 | Kathy Bates, Anthony Head | |
| 1,395 | October 14, 2011 | Liza Minnelli, Adam Pally | |
| 1,396 | October 17, 2011 | Matt Smith, Joel Schumacher | |
| 1,397 | October 18, 2011 | Carey Mulligan, Paula Poundstone | |
| 1,398 | October 19, 2011 | Carla Gugino, Joe Matarese | |
| 1,399 | October 20, 2011 | Tom Lennon, Sarah Paulson | |
| 1,400 | October 21, 2011 | Jeffrey Tambor, Laura Jansen | Cory Kahaney |
| 1,401 | October 27, 2011 | Kunal Nayyar | |
| 1,402 | October 28, 2011 | Olivia Munn, Judy Gold | Duran Duran |
| 1,403 | October 31, 2011 | Zooey Deschanel, Neil Gaiman | Amanda Palmer |

### November

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,404 | November 1, 2011 | Maria Bello, Jake Johnson | |
| 1,405 | November 2, 2011 | Ted Danson, Bitsie Tulloch | |
| 1,406 | November 3, 2011 | Alan Alda, Ariel Tweto | |
| 1,407 | November 4, 2011 | Neil Patrick Harris | Imelda May |
| 1,408 | November 7, 2011 | Jeffrey Dean Morgan featuring Alfred Molina as Geoff Peterson | The Grascals |
| 1,409 | November 8, 2011 | Jennifer Tilly, Lawrence Block featuring Dominic Monaghan as Geoff Peterson | |
| 1,410 | November 9, 2011 | Ellen Barkin, Dave Attell featuring Thomas Lennon as Geoff Peterson | |
| 1,411 | November 10, 2011 | Molly Shannon, Michael K. Williams featuring Larry King as Geoff Peterson | |
| 1,412 | November 11, 2011 | Drew Carey, Linda Cunningham featuring Louie Anderson as Geoff Peterson | |
| 1,413 | November 14, 2011 | Poppy Montgomery, Charlie Higson featuring Lauren Graham as Geoff Peterson | |
| 1,414 | November 15, 2011 | Ewan McGregor featuring Paula Poundstone as Geoff Peterson | |
| 1,415 | November 16, 2011 | Michael Ian Black, Alex Kingston featuring Angela Kinsey as Geoff Peterson | |
| 1,416 | November 17, 2011 | Robin Williams featuring Jason Schwartzman as Geoff Peterson | |
| 1,417 | November 18, 2011 | Don Rickles, Beth Behrs featuring Shadoe Stevens as Geoff Peterson | |
| 1,418 | November 21, 2011 | Robin Williams, Johnny Galecki | |
| 1,419 | November 22, 2011 | Jason Segel, Eliza Coupe | |
| 1,420 | November 23, 2011 | Ty Burrell, Wilford Brimley | |
| 1,421 | November 28, 2011 | Aisha Tyler featuring Thomas Lennon as Geoff Peterson | Justin Moore |
| 1,422 | November 29, 2011 | Margaret Cho, Michael Connelly featuring Thomas Lennon as Geoff Peterson | |
| 1,423 | November 30, 2011 | David Sedaris, Jeff Cesario featuring Thomas Lennon as Geoff Peterson | |

### December

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,424 | December 1, 2011 | Kristin Chenoweth, Ken Tucker | |
| 1,425 | December 2, 2011 | Ana Gasteyer, Beth Behrs | |
| 1,426 | December 5, 2011 | Justin Long, Noomi Rapace | |
| 1,427 | December 6, 2011 | Valerie Bertinelli | Henry Cho |
| 1,428 | December 7, 2011 | Trace Adkins | Michael Palascak |
| 1,429 | December 8, 2011 | Pierce Brosnan, Laura Lippman | |
| 1,430 | December 9, 2011 | Richard Lewis | Needtobreathe |
| 1,431 | December 12, 2011 | DJ Qualls, Cat Cora | |
| 1,432 | December 13, 2011 | Ben Kingsley, Morena Baccarin | |
| 1,433 | December 14, 2011 | Kenneth Branagh, Patton Oswalt | |
| 1,434 | December 15, 2011 | Sean Hayes, John Hodgman | |
| 1,435 | December 16, 2011 | Mindy Kaling, Nick Griffin | |
| 1,436 | December 19, 2011 | Regis Philbin featuring Thomas Lennon as Geoff Peterson | Goo Goo Dolls |
| 1,437 | December 20, 2011 | Robin Wright, Parker Young | |
| 1,438 | December 21, 2011 | Jason Lee, Felicity Jones | Black Dub |
| 1,439 | December 22, 2011 | Kyra Sedgwick | Frankie Ballard |
| 1,440 | December 23, 2011 | Jason Segel, Johnny Galecki | |

## 2012
### January

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-85 | January 2, 2012 | Tim Meadows | Eliza Doolittle, Myq Kaplan |
| 8-86 | January 3, 2012 | Carrie Fisher, Matthew Gray Gubler | |
| 8-87 | January 4, 2012 | RZA, Melissa Rauch | |
| 8-88 | January 5, 2012 | Tom Selleck, Daniela Ruah | |
| 8-89 | January 6, 2012 | Michael Clarke Duncan, Laura Prepon | |
| 8-90 | January 9, 2012 | Howie Mandel | Randy Houser |
| 8-91 | January 10, 2012 | Isaac Mizrahi, Sophia Bush | |
| 8-92 | January 11, 2012 | Adam Goldberg, Mercedes Masohn | |
| 8-93 | January 12, 2012 | Hugh Laurie | |
| 8-94 | January 13, 2012 | Kristen Bell | Louie Anderson |
| 8-95 | January 16, 2012 | Lucy Liu, Kevin Sorbo | |
| 8-96 | January 17, 2012 | Colin Firth, Lynette Rice | |
| 8-97 | January 18, 2012 | David Duchovny, Dr. Sanjay Gupta | |
| 8-98 | January 19, 2012 | Steven Wright, Sara Paxton | |
| 8-99 | January 20, 2012 | Larry the Cable Guy | 3 Doors Down |
| 8-100 | January 30, 2012 | Don Cheadle, Andrea Riseborough | |
| 8-101 | January 31, 2012 | Ringo Starr | |

### February

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-102 | February 1, 2012 | William Shatner, Kathryn Hahn | |
| 8-103 | February 2, 2012 | Daniel Radcliffe | Mark Forward |
| 8-104 | February 3, 2012 | Rachel Bilson, Jonathan Ames | |
| 8-105 | February 6, 2012 | Mark Harmon, Martha Plimpton | |
| 8-106 | February 7, 2012 | Kenneth Branagh | Chad Daniels |
| 8-107 | February 8, 2012 | Christina Applegate, Brad Goreski | |
| 8-108 | February 9, 2012 | Lisa Kudrow | "Weird Al" Yankovic |
| 8-109 | February 10, 2012 | Chelsea Handler, Dan Riskin | |
| 8-110 | February 13, 2012 | Carol Burnett, Phil Keoghan | |
| 8-111 | February 14, 2012 | Joss Stone | Joss Stone, Dave Stewart |
| 8-112 | February 15, 2012 | Jon Cryer, Morena Baccarin | |
| 8-113 | February 16, 2012 | Jeffrey Tambor, Amy Smart | |
| 8-114 | February 17, 2012 | Simon Helberg | Margaret Cho |
| 8-115 | February 20, 2012 | Jayma Mays, Jean-Michel Cousteau | |
| 8-116 | February 21, 2012 | Bill Maher, Eloise Mumford | |
| 8-117 | February 22, 2012 | Carson Kressley | Ramin Nazer |
| 8-118 | February 23, 2012 | Malin Åkerman, Jon Ronson | |
| 8-119 | February 24, 2012 | John Waters, Jennifer Carpenter | |
| 8-120 | February 27, 2012 | Eric Idle, Sarah Paulson | |
| 8-121 | February 28, 2012 | Dr. Mehmet Oz, Carrie Keagan | |
| 8-122 | February 29, 2012 | Tom Lennon, Phil Plait | |

### March

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-123 | March 1, 2012 | Henry Winkler, Jay Baruchel | |
| 8-124 | March 2, 2012 | Dennis Miller | The Light Brigade |
| 8-125 | March 5, 2012 | Courteney Cox | Louie Anderson |
| 8-126 | March 6, 2012 | Joel McHale, Dan Boulger | |
| 8-127 | March 7, 2012 | Susan Sarandon | Rondell Sheridan |
| 8-128 | March 8, 2012 | Raquel Welch, Carl Edwards | |
| 8-129 | March 9, 2012 | Kristin Davis, Chris O'Dowd | |
| 8-130 | March 12, 2012 | Leslie Bibb, David Milch | |
| 8-131 | March 13, 2012 | Jason Segel, Jennette McCurdy | |
| 8-132 | March 14, 2012 | Regis Philbin | |
| 8-133 | March 19, 2012 | Anne Rice, Geoff Tate | |
| 8-134 | March 20, 2012 | Kathy Bates, Brad Goreski | |
| 8-135 | March 21, 2012 | Elizabeth Banks | |

### April

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-136 | April 2, 2012 | Julie Chen, Pau Gasol | |
| 8-137 | April 3, 2012 | Ted Danson, Hannah Simone | |
| 8-138 | April 4, 2012 | Jeffrey Tambor | The Lumineers |
| 8-139 | April 5, 2012 | Jeffrey Dean Morgan, Bryan Miller | |
| 8-140 | April 6, 2012 | Laura Linney, Grant Imahara | |
| 8-141 | April 9, 2012 | Billy Gardell, Ian Gomez | |
| 8-142 | April 10, 2012 | Guy Pearce, Jessica St. Clair | |
| 8-143 | April 11, 2012 | Adam Goldberg, Robbie Montgomery | |
| 8-144 | April 12, 2012 | Judd Apatow, Katherine Jenkins | |
| 8-145 | April 13, 2012 | Sean Hayes, Lena Dunham | |
| 8-146 | April 16, 2012 | Kathy Griffin | M. Ward |
| 8-147 | April 17, 2012 | Kevin Kline, Alice Eve | |
| 8-148 | April 18, 2012 | Michael Sheen, Michael Ian Black | |
| 8-149 | April 19, 2012 | Kelly Preston, Joel Stein | |
| 8-150 | April 20, 2012 | Emily Deschanel, Jerry Ferrara | |
| 8-151 | April 26, 2012 | Toni Collette, Mike Massimino | |
| 8-152 | April 27, 2012 | Patton Oswalt, Phoebe Tonkin | |
| 8-153 | April 30, 2012 | Jim Gaffigan, Cat Cora | |

### May

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-154 | May 1, 2012 | Jesse Tyler Ferguson, Lennon Parham | |
| 8-155 | May 2, 2012 | Anjelica Huston, Reno Wilson | |
| 8-156 | May 3, 2012 | Julie Andrews, Michael Emerson | |
| 8-157 | May 4, 2012 | Zooey Deschanel, Patrick Warburton | |
| 8-158 | May 7, 2012 | Poppy Montgomery, Steve Guttenberg | |
| 8-159 | May 8, 2012 | Steven Tyler, Jaime King | |
| 8-160 | May 9, 2012 | Jenna Fischer, Danny Huston | |
| 8-161 | May 10, 2012 | Christiane Amanpour, Anna Kendrick | |
| 8-162 | May 11, 2012 | Larry King, Anna Chlumsky | |
| The Late Late Show with Craig Ferguson in Scotland ||||
| 8-163 | May 14, 2012 | Mila Kunis, Michael Clarke Duncan, Rashida Jones, David Sedaris, Ariel Tweto | The Imagineers |
| 8-164 | May 15, 2012 | Alex Salmond, Mila Kunis, Rashida Jones | The Imagineers |
| 8-165 | May 16, 2012 | Michael Clarke Duncan, Mila Kunis | The Imagineers |
| 8-166 | May 17, 2012 | Mila Kunis, Ariel Tweto, Fred MacAulay | The Imagineers |
| 8-167 | May 18, 2012 | David Sedaris, Mila Kunis, Ariel Tweto, Rashida Jones | The Imagineers |
| 8-168 | May 21, 2012 | Jeffrey Dean Morgan, Steven Wright | |
| 8-169 | May 22, 2012 | Billy Bob Thornton, Sonya Walger | |
| 8-170 | May 23, 2012 | Jennifer Love Hewitt, Rutina Wesley | |
| 8-171 | May 24, 2012 | Alfred Molina | Sara Watkins |
| 8-172 | May 25, 2012 | Jason Alexander, Angela Kinsey | |
| 8-173 | May 28, 2012 | Benjamin McKenzie, Shohreh Aghdashloo | |
| 8-174 | May 29, 2012 | DJ Qualls, Wolfgang Puck | |
| 8-175 | May 30, 2012 | Howie Mandel, Sutton Foster | |
| 8-176 | May 31, 2012 | Carrie Fisher, Tony Hale | |

### June

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-177 | June 1, 2012 | Jeff Garlin, Sonya Walger | |
| 8-178 | June 11, 2012 | Jason Schwartzman | Rory Scovel |
| 8-179 | June 12, 2012 | Andy García, Cody Horn | |
| 8-180 | June 13, 2012 | Elliot Page, Lee Brice | |
| 8-181 | June 14, 2012 | Don Rickles, Max Greenfield | |
| 8-182 | June 15, 2012 | Jenna Elfman | The Imagineers |
| 8-183 | June 18, 2012 | Alex Salmond, Kelly Macdonald, Kevin McKidd | |
| 8-184 | June 19, 2012 | Steve Carell, Don Winslow | |
| 8-185 | June 20, 2012 | Morgan Freeman, Ben Dukes | |
| 8-186 | June 21, 2012 | Jeff Daniels, John Irving | |
| 8-187 | June 22, 2012 | Mark Wahlberg, Sloane Crosley | |
| 8-188 | June 25, 2012 | Elijah Wood, Kathleen Rose Perkins | |
| 8-189 | June 26, 2012 | William Shatner, Breckin Meyer | |
| 8-190 | June 27, 2012 | Lisa Kudrow, Harvey Weinstein | |
| 8-191 | June 28, 2012 | Denis Leary, Brandi Carlile | |
| 8-192 | June 29, 2012 | Tyler Perry | Matt Kirshen |

### July

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 8-193 | July 16, 2012 | Julie Chen, Chris Messina | |
| 8-194 | July 17, 2012 | Cedric the Entertainer, Ari Graynor | |
| 8-195 | July 18, 2012 | Ray Romano | Trampled by Turtles |
| 8-196 | July 19, 2012 | Kenneth Branagh | Ted Alexandro |
| 8-197 | July 20, 2012 | Jason Biggs, Jordana Brewster | Brian Scolaro |
| 8-198 | July 23, 2012 | George Hamilton, Julie Gonzalo | |
| 8-199 | July 24, 2012 | Minnie Driver, Colin Mochrie | |
| 8-200 | July 25, 2012 | Matthew McConaughey | |
| 8-201 | July 26, 2012 | Emile Hirsch, Ariel Tweto | |
| 8-202 | July 27, 2012 | Vince Vaughn | |
| 8-203 | July 30, 2012 | Emma Roberts, Paula Poundstone | |
| 8-204 | July 31, 2012 | Rosie Perez | |

### August

| No. | Original air date | Guest(s) | Musical/entertainment guest(s) |
| 1,560 | August 1, 2012 | Selma Blair, Adam Savage | |
| 1,561 | August 2, 2012 | Rashida Jones, Julie Delpy | |
| 1,562 | August 3, 2012 | Edward Norton, Malin Åkerman | |
| 1,563 | August 6, 2012 | Stephen King, Dave Barry | Rock Bottom Remainders |
| 1,564 | August 7, 2012 | Rachael Ray | The Imagineers |
| 1,565 | August 8, 2012 | Chris Hardwick, Carla Gugino | |
| 1,566 | August 27, 2012 | Kristen Bell | |
| 1,567 | August 28, 2012 | Larry King | Michelle Buteau |
| 1,568 | August 29, 2012 | Jeffrey Dean Morgan, Fiona Gubelmann | Nick Griffin |
| 1,569 | August 30, 2012 | Lisa Kudrow, Marc Maron | |
| 1,570 | August 31, 2012 | Seth Green, Sutton Foster | Sutton Foster |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,571 | September 4, 2012 (2012-09-04) | Kathy Griffin | N/A |
| 1,572 | September 5, 2012 (2012-09-05) | Jeremy Irons, Monica Potter | N/A |
| 1,573 | September 6, 2012 (2012-09-06) | Angela Kinsey, David Simon | The Heavy |
| 1,574 | September 7, 2012 (2012-09-07) | Kunal Nayyar, Lauren Miller, Amber Earnest | N/A |
| 1,575 | September 10, 2012 (2012-09-10) | Ben Stein, Rhona Mitra | Brooks McBeth |
| 1,576 | September 11, 2012 (2012-09-11) | Adam Goldberg, Alison Becker | N/A |
| 1,577 | September 12, 2012 (2012-09-12) | Heather Graham, Joel Stein | N/A |
| 1,578 | September 13, 2012 (2012-09-13) | Katey Sagal, Michael J. Massimino | N/A |
| 1,579 | September 14, 2012 (2012-09-14) | Tom Lennon, Brit Marling | N/A |
| 1,580 | September 17, 2012 (2012-09-17) | Julie Chen, Warren Sapp | Lianne La Havas |
| 1,581 | September 18, 2012 (2012-09-18) | John Goodman, Arjay Smith | Melissa Etheridge |
| 1,582 | September 19, 2012 (2012-09-19) | Sophia Bush | N/A |
| 1,583 | September 20, 2012 (2012-09-20) | Nikki Reed, Mitch Albom | N/A |
| 1,584 | September 21, 2012 (2012-09-21) | Neil Patrick Harris | Gerry Dee |
| 1,585 | September 24, 2012 (2012-09-24) | Dennis Quaid, Ellie Kemper | N/A |
| 1,586 | September 25, 2012 (2012-09-25) | Tom Selleck, June Diane Raphael | N/A |
| 1,587 | September 26, 2012 (2012-09-26) | Jim Parsons | Dispatch |
| 1,588 | September 27, 2012 (2012-09-27) | Anne Heche, Jennifer Carpenter | N/A |
| 1,589 | September 28, 2012 (2012-09-28) | Michael C. Hall, Martha Plimpton | N/A |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,590 | October 1, 2012 (2012-10-01) | Jeff Garlin, Ethan Hawke | Lynyrd Skynyrd |
| 1,591 | October 2, 2012 (2012-10-02) | Mindy Kaling | Carrot Top |
| 1,592 | October 3, 2012 (2012-10-03) | Keanu Reeves, Dan Riskin | N/A |
| 1,593 | October 4, 2012 (2012-10-04) | Roseanne Barr, Keke Palmer | N/A |
| 1,594 | October 5, 2012 (2012-10-05) | Sanjay Gupta, Ginnifer Goodwin | N/A |
| 1,595 | October 15, 2012 (2012-10-15) | Jeff Goldblum, Sarah Paulson | N/A |
| 1,596 | October 16, 2012 (2012-10-16) | Lauren Graham, James Patterson | Michael Kiwanuka |
| 1,597 | October 17, 2012 (2012-10-17) | Carson Kressley, Kay Adams | N/A |
| 1,598 | October 18, 2012 (2012-10-18) | Kelsey Grammer, Casey Wilson | Ben Hague |
| 1,599 | October 19, 2012 (2012-10-19) | Chelsea Handler, Nina Conti | Allen Stone |
| 1,600 | October 22, 2012 (2012-10-22) | Bryan Cranston, Lisa Masterson | N/A |
| 1,601 | October 23, 2012 (2012-10-23) | Phil McGraw, Hana Mae Lee | N/A |
| 1,602 | October 24, 2012 (2012-10-24) | Susan Sarandon, David Benioff | Thomas Dale |
| 1,603 | October 25, 2012 (2012-10-25) | Michael Chiklis, Maggie Grace | N/A |
| 1,604 | October 26, 2012 (2012-10-26) | Amanda Peet, John Cho | N/A |
| 1,605 | October 29, 2012 (2012-10-29) | Tom Hanks | Phil Hanley |
| 1,606 | October 30, 2012 (2012-10-30) | Jay Leno | Lynyrd Skynyrd |
| 1,607 | October 31, 2012 (2012-10-31) | Rashida Jones, David Morrissey | N/A |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,608 | November 1, 2012 (2012-11-01) | Joel McHale, Alton Brown | N/A |
| 1,609 | November 2, 2012 (2012-11-02) | Michael Sheen | Thomas Dale |
| 1,610 | November 5, 2012 (2012-11-05) | Tenacious D, Sarah Shahi | N/A |
| 1,611 | November 7, 2012 (2012-11-07) | Matthew Perry | RZA |
| 1,612 | November 8, 2012 (2012-11-08) | LL Cool J, Naeomie Harris | Sutton Foster |
| 1,613 | November 9, 2012 (2012-11-09) | Eric Idle, Emily VanCamp | N/A |
| 1,614 | November 12, 2012 (2012-11-12) | DJ Qualls, Nikki Reed, Dave Attell | N/A |
| 1,615 | November 13, 2012 (2012-11-13) | Katlin Mastandrea, Toby Keith, J. R. Martinez | N/A |
| 1,616 | November 14, 2012 (2012-11-14) | Billy Crystal, Bérénice Marlohe | N/A |
| 1,617 | November 15, 2012 (2012-11-15) | Max Greenfield, Lucy Punch | N/A |
| 1,618 | November 16, 2012 (2012-11-16) | Richie Sambora, James Spader, Cynthia Littleton | N/A |
| 1,619 | November 19, 2012 (2012-11-19) | Regis Philbin, Katie Aselton | N/A |
| 1,620 | November 20, 2012 (2012-11-20) | Marion Cotillard, Kevin Pollak | N/A |
| 1,621 | November 26, 2012 (2012-11-26) | Lily Tomlin, Matthew Gray Gubler | N/A |
| 1,622 | November 27, 2012 (2012-11-27) | James Marsden, Daniela Ruah | Cory Kahaney |
| 1,623 | November 28, 2012 (2012-11-28) | Lewis Black, Karen Gillan | LP |
| 1,624 | November 29, 2012 (2012-11-29) | Kristin Davis, Nat Faxon | N/A |
| 1,625 | November 30, 2012 (2012-11-30) | Tom Hanks, Tim Meadows, Mayim Bialik | N/A |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,626 | December 3, 2012 (2012-12-03) | Seth MacFarlane, Miranda Kerr | Richie Sambora performs "The Late Late Show Theme" with Ferguson, and "Every Road Leads Home to You" from Aftermath of the Lowdown |
| 1,627 | December 4, 2012 (2012-12-04) | Reba McEntire, Keegan-Michael Key | Richie Sambora performs "The Late Late Show Theme", and "Seven Years Gone" from Aftermath of the Lowdown |
| 1,628 | December 5, 2012 (2012-12-05) | Cheryl Hines, Peter Sagal | Richie Sambora performs "The Late Late Show Theme" with Larry King |
| 1,629 | December 6, 2012 (2012-12-06) | Denis Leary | Richie Sambora performs "The Late Late Show Theme" with Eddie Izzard, and "Wanted Dead or Alive" from the Bon Jovi album Slippery When Wet |
| 1,630 | December 7, 2012 (2012-12-07) | Julie Delpy, Lamorne Morris | Richie Sambora performs "The Late Late Show Theme" with Denis Leary, and later, "Sugar Daddy" from Aftermath of the Lowdown with Ferguson singing lead. |
| 1,631 | December 10, 2012 (2012-12-10) | Kristen Stewart, Sloane Crosley | N/A |
| 1,632 | December 11, 2012 (2012-12-11) | Betty White, Morena Baccarin | Terry Fator (Stand-up routine) |
| 1,633 | December 12, 2012 (2012-12-12) | Chris O'Dowd, Beth Behrs | N/A |
| 1,634 | December 13, 2012 (2012-12-13) | Howie Mandel, Olivia Williams | N/A |
| 1,635 | December 14, 2012 (2012-12-14) | Bradley Cooper, Wolfgang Puck | N/A |
| 1,636 | December 17, 2012 (2012-12-17) | Sarah Chalke, Anne Rice | N/A |
| 1,637 | December 18, 2012 (2012-12-18) | Don Johnson, Brad Goreski | N/A |
| 1,638 | December 19, 2012 (2012-12-19) | Judd Apatow, Joanne Froggatt | N/A |
| 1,639 | December 20, 2012 (2012-12-20) | Quentin Tarantino | N/A |
| 1,640 | December 21, 2012 (2012-12-21) | Jamie Foxx, Bianca Kajlich | N/A |

## 2013
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,641 | January 7, 2013 (2013-01-07) | Billy Gardell, Krysten Ritter | N/A |
| 1,642 | January 8, 2013 (2013-01-08) | Billy Connolly, Meaghan Rath | N/A |
| 1,643 | January 9, 2013 (2013-01-09) | Steven Wright, Genesis Rodriguez | N/A |
| 1,644 | January 10, 2013 (2013-01-10) | Tim Allen, Margaret Cho | N/A |
| 1,645 | January 11, 2013 (2013-01-11) | Julie Chen, Angela Kinsey | N/A |
| 1,646 | January 14, 2013 (2013-01-14) | Jenna Elfman, Guillermo del Toro | N/A |
| 1,647 | January 15, 2013 (2013-01-15) | Lena Dunham, Bill Pullman | N/A |
| 1,648 | January 16, 2013 (2013-01-16) | Don Cheadle, DJ Qualls | N/A |
| 1,649 | January 17, 2013 (2013-01-17) | Julia Stiles, Jerry Ferrara | Tom Cotter (Stand-up routine) |
| 1,650 | January 18, 2013 (2013-01-18) | Carrie Fisher, Steven Yeun | N/A |
| 1,651 | January 28, 2013 (2013-01-28) | Kathy Griffin, Michael Weatherly | Bone Patrol |
| 1,652 | January 29, 2013 (2013-01-29) | Simon Helberg, Maria Bamford | Bone Patrol |
| 1,653 | January 30, 2013 (2013-01-30) | Dominic Monaghan, Ellie Kemper | Bone Patrol |
| 1,654 | January 31, 2013 (2013-01-31) | Rashida Jones, Julie Gonzalo | Bone Patrol |

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,655 | February 1, 2013 (2013-02-01) | Joe Theismann, Ariel Tweto | Bone Patrol |
| 1,656 | February 3, 2013 (2013-02-03) | The Craig Ferguson Super Bowl Special: Drew Brees, Steve Carell, Nikki Reed, Channing Tatum, Julie Chen, Neil Patrick Harris | Bone Patrol |
| 1,657 | February 4, 2013 (2013-02-04) | Zooey Deschanel, Adhir Kalyan | N/A |
| 1,658 | February 5, 2013 (2013-02-05) | David Boreanaz, Alison Becker | N/A |
| 1,659 | February 6, 2013 (2013-02-06) | Emmy Rossum, Jon Ronson | N/A |
| 1,660 | February 7, 2013 (2013-02-07) | Amanda Peet, Paul Williams | N/A |
| 1,661 | February 8, 2013 (2013-02-08) | Alfred Molina | Ophira Eisenberg (Stand-up routine) |
| 1,662 | February 11, 2013 (2013-02-11) | Julie Andrews, Grace Park | N/A |
| 1,663 | February 12, 2013 (2013-02-12) | Ted Danson, Teresa Palmer | N/A |
| 1,664 | February 13, 2013 (2013-02-13) | Russell Brand, Allison Williams | N/A |
| 1,665 | February 14, 2013 (2013-02-14) | George Lopez, Sutton Foster | N/A |
| 1,666 | February 15, 2013 (2013-02-15) | Jane Lynch, Mario Lopez | N/A |
| 1,667 | February 18, 2013 (2013-02-18) | Jacki Weaver, Jim Gaffigan | Nicola Benedetti ("Romance: Andante") |
| 1,668 | February 19, 2013 (2013-02-19) | Jon Cryer, Melissa Benoist | N/A |
| 1,669 | February 20, 2013 (2013-02-20) | Lisa Kudrow, Bonnie Raitt | N/A |
| 1,670 | February 21, 2013 (2013-02-21) | Kunal Nayyar, Molly Shannon | N/A |
| 1,671 | February 22, 2013 (2013-02-22) | William Shatner, Alona Tal | N/A |
| 1,672 | February 25, 2013 (2013-02-25) | Keith Olbermann, Coco Rocha | N/A |
| 1,673 | February 26, 2013 (2013-02-26) | Sharon Osbourne, Matthew Lillard | N/A |
| 1,674 | February 27, 2013 (2013-02-27) | Mike Tyson, Tom Lennon | N/A |
| 1,675 | February 28, 2013 (2013-02-28) | David Duchovny, Ashley Madekwe | N/A |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,676 | March 1, 2013 (2013-03-01) | Trace Adkins, Naya Rivera | N/A |
| 1,677 | March 4, 2013 (2013-03-04) | Jeffrey Dean Morgan, Katheryn Winnick | N/A |
| 1,678 | March 5, 2013 (2013-03-05) | Larry King, Abbie Cornish | N/A |
| 1,679 | March 6, 2013 (2013-03-06) | Christina Hendricks, Jackie Collins | N/A |
| 1,680 | March 7, 2013 (2013-03-07) | Zach Braff, Gillian Jacobs | N/A |
| 1,681 | March 8, 2013 (2013-03-08) | Chi McBride, Laurie Holden | N/A |
| 1,682 | March 11, 2013 (2013-03-11) | George Hamilton, Jessica Lucas | N/A |
| 1,683 | March 12, 2013 (2013-03-12) | Minnie Driver, Ben Schwartz | N/A |
| 1,684 | March 13, 2013 (2013-03-13) | Olivia Wilde, Windell Middlebrooks | N/A |
| 1,685 | March 14, 2013 (2013-03-14) | Monica Potter, Jim Rome | N/A |
| 1,686 | March 15, 2013 (2013-03-15) | Megan Mullally, Alison Brie | N/A |
| 1,687 | March 18, 2013 (2013-03-18) | Jenna-Louise Coleman, Seth Green | N/A |
| 1,688 | March 19, 2013 (2013-03-19) | Michelle Monaghan, John Green | N/A |
| 1,689 | March 20, 2013 (2013-03-20) | Aaron Eckhart, Kellie Pickler | N/A |
| 1,690 | March 25, 2013 (2013-03-25) | Morgan Freeman, Vera Farmiga | N/A |
| 1,691 | March 26, 2013 (2013-03-26) | Sarah Chalke, Lawrence Block | N/A |
| 1,692 | March 27, 2013 (2013-03-27) | Don Rickles, Radha Mitchell | N/A |

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,693 | April 8, 2013 (2013-04-08) | Max Greenfield, Debbie Reynolds | N/A |
| 1,694 | April 9, 2013 (2013-04-09) | Drew Carey, Jane Levy | N/A |
| 1,695 | April 10, 2013 (2013-04-10) | Julia Louis-Dreyfus | He's My Brother She's My Sister ("Same Old Ground") |
| 1,696 | April 11, 2013 (2013-04-11) | Anna Chlumsky, Carl Reiner | N/A |
| 1,697 | April 12, 2013 (2013-04-12) | Jason Biggs, Keke Palmer | N/A |
| 1,698 | April 15, 2013 (2013-04-15) | Rob Lowe, Larry King | N/A |
| Special format episode. Cold open monologue on the Boston bombing. Last-minute guest Larry King discusses news broadcasting on tragic events. Opening credits, comedic monologue, sidekicks Geoff Peterson and Secretariat are omitted. ||||
| 1,699 | April 16, 2013 (2013-04-16) | Selma Blair, Nathan Fielder | N/A |
| 1,700 | April 17, 2013 (2013-04-17) | Brad Goreski, Melissa Rauch | N/A |
| 1,701 | April 18, 2013 (2013-04-18) | Ginnifer Goodwin, Salman Rushdie | N/A |
| 1,702 | April 19, 2013 (2013-04-19) | Harrison Ford, Ariel Tweto | N/A |
| 1,703 | April 22, 2013 (2013-04-22) | Kat Dennings, Philip Kerr | N/A |
| 1,704 | April 23, 2013 (2013-04-23) | Kevin Bacon, Rebecca Hall | N/A |
| 1,705 | April 24, 2013 (2013-04-24) | Rainn Wilson, Karen Gillan | N/A |
| 1,706 | April 25, 2013 (2013-04-25) | Zac Efron, Anna Quindlen | N/A |
| 1,707 | April 26, 2013 (2013-04-26) | Robin Wright | Myq Kaplan (Stand-up routine) |
| 1,708 | April 29, 2013 (2013-04-29) | Mary McCormack, Jim O'Heir | N/A |
| 1,709 | April 30, 2013 (2013-04-30) | Larry the Cable Guy, Abigail Spencer | N/A |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,710 | May 1, 2013 (2013-05-01) | Michael Ian Black, Lena Headey | N/A |
| 1,711 | May 2, 2013 (2013-05-02) | Pierce Brosnan | Tone Bell (Stand-up routine) |
| 1,712 | May 3, 2013 (2013-05-03) | Angela Kinsey, Simon Amstell | N/A |
| 1,713 | May 6, 2013 (2013-05-06) | Isla Fisher, Jim Rash | N/A |
| 1,714 | May 7, 2013 (2013-05-07) | Ryan Seacrest, Andrea Osvárt | N/A |
| 1,715 | May 8, 2013 (2013-05-08) | Lauren Graham | Ben Dukes ("Old Fixer Upper") |
| 1,716 | May 9, 2013 (2013-05-09) | Bob Saget, Sarah Hyland | N/A |
| 1,717 | May 10, 2013 (2013-05-10) | Tom Lennon, Cat Deeley | N/A |
| 1,718 | May 13, 2013 (2013-05-13) | John Cho, Sara Rue | N/A |
| 1,719 | May 14, 2013 (2013-05-14) | Ray Liotta | Pistol Annies ("Unhappily Married"), DeAnne Smith (Stand-up routine) |
| 1,720 | May 15, 2013 (2013-05-15) | Ice-T, Paula Poundstone | N/A |
| 1,721 | May 16, 2013 (2013-05-16) | Paul Reiser, Yunjin Kim | N/A |
| 1,722 | May 17, 2013 (2013-05-17) | William Shatner, Natalie Dormer | N/A |
| 1,723 | May 20, 2013 (2013-05-20) | Heather Graham, David Benioff | N/A |
| 1,724 | May 21, 2013 (2013-05-21) | Zach Galifianakis, Andrea Riseborough | N/A |
| 1,725 | May 22, 2013 (2013-05-22) | Stephen Fry | N/A |
| 1,726 | May 27, 2013 (2013-05-27) | Ben Kingsley, Alia Shawkat | N/A |
| 1,727 | May 28, 2013 (2013-05-28) | Elliot Page, George Stroumboulopoulos | N/A |
| 1,728 | May 29, 2013 (2013-05-29) | Howie Mandel, Brit Marling | N/A |
| 1,729 | May 30, 2013 (2013-05-30) | Jeff Garlin, Anne Heche | N/A |
| 1,730 | May 31, 2013 (2013-05-31) | Kathy Griffin | Bad Rabbits ("Can't Fool Me") |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,731 | June 3, 2013 (2013-06-03) | Steven Tyler, Olga Kurylenko | N/A |
| 1,732 | June 4, 2013 (2013-06-04) | Bill Maher, Cat Cora | N/A |
| 1,733 | June 5, 2013 (2013-06-05) | Dr. Sanjay Gupta, Gretchen Wilson | N/A |
| 1,734 | June 6, 2013 (2013-06-06) | Betty White, Sarah Paulson | N/A |
| 1,735 | June 7, 2013 (2013-06-07) | Ethan Hawke, Jamie Chung | N/A |
| 1,736 | June 10, 2013 (2013-06-10) | Jonah Hill, Tony Kanaan | N/A |
| 1,737 | June 11, 2013 (2013-06-11) | Margaret Cho, Hugh Dancy | N/A |
| 1,738 | June 12, 2013 (2013-06-12) | Valerie Bertinelli, Adam Ray | N/A |
| Ferguson does show and tell on his Banff World Television Festival Sir Peter Ustinov Comedy Award. ||||
| 1,739 | June 13, 2013 (2013-06-13) | Seth Rogen, Elisabeth Moss | N/A |
| 1,740 | June 14, 2013 (2013-06-14) | Emily Mortimer | Barry Rothbart (Stand-up routine) |
| 1,741 | June 17, 2013 (2013-06-17) | Carson Kressley, Rachelle Lefevre | N/A |
| 1,742 | June 18, 2013 (2013-06-18) | Angie Harmon, Ben Mezrich | N/A |
| 1,743 | June 19, 2013 (2013-06-19) | Rosie Perez | The Rubens ("The Day You Went Away") |
| 1,744 | June 20, 2013 (2013-06-20) | Lewis Black | Matt Morales (Stand-up Routine) |
| 1,745 | June 21, 2013 (2013-06-21) | Maggie Gyllenhaal, Matt Goldich | N/A |
| 1,746 | June 24, 2013 (2013-06-24) | Toni Collette, Dylan Moran | N/A |
| 1,747 | June 25, 2013 (2013-06-25) | Breckin Meyer, Wendie Malick | N/A |
| 1,748 | June 26, 2013 (2013-06-26) | Sandra Bullock, Jim McDonald | N/A |
| 1,749 | June 27, 2013 (2013-06-27) | Channing Tatum, Marc Maron | N/A |
| 1,750 | June 28, 2013 (2013-06-28) | Tenacious D, Moon Bloodgood | N/A |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,751 | July 8, 2013 (2013-07-08) | Heather Locklear | Louie Anderson (stand-up routine) |
| 1,752 | July 9, 2013 (2013-07-09) | Morgan Freeman | Cathy Ladman (stand-up routine) |
| 1,753 | July 10, 2013 (2013-07-10) | Cedric the Entertainer, Jess Weixler | N/A |
| 1,754 | July 11, 2013 (2013-07-11) | Maria Bello, Scott Adsit | N/A |
| 1,755 | July 12, 2013 (2013-07-12) | Jeff Daniels | Jeff Daniels ("Have a Good Life Then Die"), Sarah Tiana (Stand-up routine) |
| 1,756 | July 15, 2013 (2013-07-15) | Julie Chen | Michael Palascak (Stand-up routine) |
| 1,757 | July 16, 2013 (2013-07-16) | Jon Hamm, Georgia King | N/A |
| 1,758 | July 17, 2013 (2013-07-17) | Anthony Hopkins, Jes Macallan | N/A |
| 1,759 | July 18, 2013 (2013-07-18) | Jeffrey Tambor | Cristela Alonzo (Stand-up routine) |
| 1,760 | July 19, 2013 (2013-07-19) | Jane Lynch | Goo Goo Dolls ("Come to Me") |
| 1,761 | July 22, 2013 (2013-07-22) | Brooke Shields, Sara Bareilles | Sara Bareilles ("Brave") |
| 1,762 | July 23, 2013 (2013-07-23) | Larry King, Anna Camp | N/A |
| 1,763 | July 24, 2013 (2013-07-24) | Matt Smith, Teri Polo | N/A |
| 1,764 | July 25, 2013 (2013-07-25) | Bill Hader, Shohreh Aghdashloo | N/A |
| 1,765 | July 26, 2013 (2013-07-26) | Lisa Kudrow | Michael McDonald (Stand-up routine) |
| 1,766 | July 29, 2013 (2013-07-29) | Courtney Love, Jeff Kurr | N/A |
| 1,767 | July 30, 2013 (2013-07-30) | Henry Winkler, Valerie Azlynn | N/A |
| 1,768 | July 31, 2013 (2013-07-31) | Jane Leeves, Ahna O'Reilly | Backstreet Boys ("Trust Me") |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,769 | August 1, 2013 (2013-08-01) | Anthony Edwards | Hugh Moore (Stand-up routine) |
| 1,770 | August 2, 2013 (2013-08-02) | Josh Wolf, Georgia King | N/A |
| 1,771 | August 5, 2013 (2013-08-05) | Minnie Driver | Minnie Driver ("Close to Me"), Baron Vaughn (Stand-up routine) |
| 1,772 | August 6, 2013 (2013-08-06) | Diane Kruger, Tony Hale | N/A |
| 1,773 | August 7, 2013 (2013-08-07) | Jeff Goldblum | Jeff Goldblum ("Straight No Chesser") |
| 1,774 | August 8, 2013 (2013-08-08) | James Marsden, Meghan Markle | N/A |
| 1,775 | August 9, 2013 (2013-08-09) | Keith Olbermann | Esther Povitsky (Stand-up routine) |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,776 | September 2, 2013 (2013-09-02) | Angela Kinsey, David Feherty | N/A |
| 1,777 | September 3, 2013 (2013-09-03) | Jay Leno | Cameron Esposito |
| 1,778 | September 4, 2013 (2013-09-04) | Elijah Wood, Brie Larson | N/A |
| 1,779 | September 5, 2013 (2013-09-05) | Vin Diesel, Sara Gilbert | N/A |
| 1,780 | September 6, 2013 (2013-09-06) | Thomas Lennon | The Wild Feathers ("The Ceiling") |
| 1,781 | September 9, 2013 (2013-09-09) | Alice Eve, Shirley Jones | N/A |
| 1,782 | September 10, 2013 (2013-09-10) | Anna Faris, Jean-Michel Cousteau | N/A |
| 1,783 | September 11, 2013 (2013-09-11) | Max Greenfield, Amy Smart | N/A |
| 1,784 | September 12, 2013 (2013-09-12) | Adam Goldberg, Jennifer Carpenter | N/A |
| 1,785 | September 13, 2013 (2013-09-13) | Seth Green | Andi Osho (Stand-up routine), Johnnyswim ("Don't Let It Get You Down") |
| 1,786 | September 16, 2013 (2013-09-16) | Dianna Agron, Joel Stein | N/A |
| 1,787 | September 17, 2013 (2013-09-17) | Queen Latifah, John Lloyd | Laura Mvula ("Green Garden") |
| 1,788 | September 18, 2013 (2013-09-18) | Megan Mullally, Tommy Lasorda | N/A |
| 1,789 | September 19, 2013 (2013-09-19) | Connie Britton, Aimee Garcia | N/A |
| 1,790 | September 20, 2013 (2013-09-20) | Neil Patrick Harris | N/A |
| 1,791 | September 23, 2013 (2013-09-23) | Jesse Tyler Ferguson, Taylor Schilling | N/A |
| 1,792 | September 24, 2013 (2013-09-24) | Ray Romano, Carl Edwards | N/A |
| 1,793 | September 25, 2013 (2013-09-25) | Julia Stiles, Keke Palmer | N/A |
| 1,794 | September 26, 2013 (2013-09-26) | Joseph Gordon-Levitt, Maggie Grace | N/A |
| 1,795 | September 27, 2013 (2013-09-27) | Julia Louis-Dreyfus | Phil Palisoul (Stand-up routine) |
| 1,796 | September 30, 2013 (2013-09-30) | Simon Helberg | The Naked and Famous ("Hearts Like Ours") |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,797 | October 1, 2013 (2013-10-01) | Patricia Heaton, Dennis Lehane | N/A |
| 1,798 | October 2, 2013 (2013-10-02) | Ben Stein, Jayma Mays | N/A |
| 1,799 | October 3, 2013 (2013-10-03) | Diane Kruger, Ken Jeong | N/A |
| 1,800 | October 4, 2013 (2013-10-04) | Justin Long | Dave Stone (Stand-up Routine) |
| 1,801 | October 7, 2013 (2013-10-07) | Zooey Deschanel, Ed Weeks | N/A |
| 1,802 | October 8, 2013 (2013-10-08) | Sarah Michelle Gellar, Guillermo Díaz | N/A |
| 1,803 | October 9, 2013 (2013-10-09) | Sean Hayes, Tom Cotter | N/A |
| 1,804 | October 10, 2013 (2013-10-10) | Steven Wright, Ginnifer Goodwin | N/A |
| 1,805 | October 11, 2013 (2013-10-11) | Rashida Jones, Brian McKim | N/A |
| 1,806 | October 14, 2013 (2013-10-14) | Malin Akerman, Jo Nesbø | Vintage Trouble ("Pelvis Pusher") |
| 1,807 | October 15, 2013 (2013-10-15) | Michael C. Hall, Laura Bell Bundy | N/A |
| 1,808 | October 16, 2013 (2013-10-16) | Robin Williams | N/A |
| 1,809 | October 17, 2013 (2013-10-17) | Allison Janney, Ben Schwartz | N/A |
| 1,810 | October 18, 2013 (2013-10-18) | Rosie Perez | Nick Cobb (Stand-up Routine) |
| 1,811 | October 28, 2013 (2013-10-28) | Katey Sagal, Richard Curtis | N/A |
| 1,812 | October 29, 2013 (2013-10-29) | Alyssa Milano, Lawrence Block | N/A |
| 1,813 | October 30, 2013 (2013-10-30) | Drew Carey, Pamela Silva Conde | N/A |
| 1,814 | October 31, 2013 (2013-10-31) | Ben Kingsley, Anne Rice | N/A |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,815 | November 1, 2013 (2013-11-01) | Geoffrey Rush | Dale Earnhardt Jr. Jr. ("If You Didn't See Me [Then You Weren't On The Dancefloor]") |
| 1,816 | November 4, 2013 (2013-11-04) | Lauren Graham, Eugenio Derbez | N/A |
| 1,817 | November 5, 2013 (2013-11-05) | Kevin Kline, Jenna Dewan | N/A |
| 1,818 | November 6, 2013 (2013-11-06) | Martin Short, Doris Kearns Goodwin | N/A |
| 1,819 | November 7, 2013 (2013-11-07) | Kat Dennings, Markus Persson | N/A |
| 1,820 | November 8, 2013 (2013-11-08) | Mary Steenburgen, Becca Tobin | N/A |
| William Shatner appeared in the cold open. ||||
| 1,821 | November 11, 2013 (2013-11-11) | LL Cool J, Carrie Keagan | N/A |
| 1,822 | November 12, 2013 (2013-11-12) | Ron Perlman, Lupita Nyong'o | N/A |
| 1,823 | November 13, 2013 (2013-11-13) | Kaley Cuoco, Kellie Pickler | N/A |
| 1,824 | November 14, 2013 (2013-11-14) | Donald Sutherland, Casey Wilson | N/A |
| 1,825 | November 15, 2013 (2013-11-15) | Steven Yeun, Summer Glau | N/A |
| 1,826 | November 18, 2013 (2013-11-18) | Kunal Nayyar | N/A |
| 1,827 | November 19, 2013 (2013-11-19) | Margaret Cho, Elettra Rossellini Wiedemann | N/A |
| 1,828 | November 20, 2013 (2013-11-20) | Nikki Reed | Joe Zimmerman (Stand-up Routine) |
| 1,829 | November 21, 2013 (2013-11-21) | David Arquette, Krysten Ritter | N/A |
| 1,830 | November 22, 2013 (2013-11-22) | Tim Meadows, Helen Fielding | N/A |
| 1,831 | November 25, 2013 (2013-11-25) | Mark Harmon, Wolfgang Puck | N/A |
| 1,832 | November 26, 2013 (2013-11-26) | Angela Kinsey | American Authors |
| William Shatner appeared in the cold open. ||||

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,833 | December 2, 2013 (2013-12-02) | Betty White, Evangeline Lilly | Josh Blue |
| 1,834 | December 3, 2013 (2013-12-03) | Will Arnett, Pau Gasol | N/A |
| 1,835 | December 4, 2013 (2013-12-04) | Aisha Tyler, Bruce McCall; Ben Schwartz appears in the cold open | N/A |
| 1,836 | December 5, 2013 (2013-12-05) | Anjelica Huston, Jackie Guerrido | N/A |
| 1,837 | December 6, 2013 (2013-12-06) | Michael Ian Black, Chris Hardwick, Marc Maron, Zoe Saldana, Mitch Albom | N/A |
| 1,838 | December 9, 2013 (2013-12-09) | Demi Lovato | Louie Anderson |
| 1,839 | December 10, 2013 (2013-12-10) | Paul Giamatti, Candice Accola | N/A |
| 1,840 | December 11, 2013 (2013-12-11) | Jim Gaffigan, Ariel Tweto | N/A |
| 1,841 | December 12, 2013 (2013-12-12) | Jason Schwartzman, Alexis Knapp; William Shatner appears in the cold open | N/A |
| 1,842 | December 13, 2013 (2013-12-13) | Michael Sheen; William Shatner appears in the cold open; Ferguson and Josh Robert Thompson do a "Christmas with Kraftwerk" skit | The Lone Bellow play "Green Eyes and a Heart of Gold" |
| 1,843 | December 16, 2013 (2013-12-16) | Joe Theismann, Kelly Rowland | N/A |
| 1,844 | December 17, 2013 (2013-12-17) | Alyssa Milano, Wilford Brimley | Wilford Brimley With The Jeff Hamilton Trio |
| 1,845 | December 18, 2013 (2013-12-18) | Natasha Lyonne, Michael Connelly | Kellie Pickler |
| 1,846 | December 19, 2013 (2013-12-19) | Cuba Gooding Jr., Emily Wickersham | N/A |
| 1,847 | December 20, 2013 (2013-12-20) | Judd Apatow | Lissie |

## 2014
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,848 | January 6, 2014 (2014-01-06) | Kathy Griffin, Haley Joel Osment | N/A |
| 1,849 | January 7, 2014 (2014-01-07) | Don Cheadle, Ivana Miličević | Jake Bugg |
| 1,850 | January 8, 2014 (2014-01-08) | Mark Wahlberg, Michaela Conlin | N/A |
| 1,851 | January 9, 2014 (2014-01-09) | Patton Oswalt, Hannah New | N/A |
| 1,852 | January 10, 2014 (2014-01-10) | Bob Saget, Jane Levy | N/A |
| 1,853 | January 13, 2014 (2014-01-13) | Kevin Bacon, Karla Souza | N/A |
| 1,854 | January 14, 2014 (2014-01-14) | Aaron Eckhart, Lynette Rice | N/A |
| 1,855 | January 15, 2014 (2014-01-15) | Tig Notaro, Julie Delpy | N/A |
| William Shatner appeared in the cold open. ||||
| 1,856 | January 16, 2014 (2014-01-16) | Kenneth Branagh | Christian Finnegan |
| 1,857 | January 17, 2014 (2014-01-17) | Chris Pine, Morena Baccarin | N/A |
| 1,858 | January 20, 2014 (2014-01-20) | Denis Leary | N/A |
| 1,859 | January 21, 2014 (2014-01-21) | Justin Long, Valerie Azlynn | N/A |
| 1,860 | January 22, 2014 (2014-01-22) | Michelle Monaghan, Michael Irvin | N/A |
| First Sandra the Rhino appearance as voiced by Josh Robert Thompson ||||
| 1,861 | January 23, 2014 (2014-01-23) | Martha Plimpton | Sarah Jarosz |
| 1,862 | January 24, 2014 (2014-01-24) | Christina Ricci, Ian Rankin | N/A |
| 1,863 | January 30, 2014 (2014-01-30) | Max Greenfield | ZZ Ward |
| 1,864 | January 31, 2014 (2014-01-31) | Hayden Panettiere | Brooke Van Poppelen |
| William Shatner appeared in the cold open. ||||

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,865 | February 3, 2014 (2014-02-03) | Larry King | Henry Cho |
| 1,866 | February 4, 2014 (2014-02-04) | Megan Mullally, J. Maarten Troost | N/A |
| 1,867 | February 5, 2014 (2014-02-05) | Jim Parsons | N/A |
| 1,868 | February 6, 2014 (2014-02-06) | John Goodman, Imogen Poots | N/A |
| 1,869 | February 7, 2014 (2014-02-07) | Tom Lennon, Sarah Paulson | N/A |
| Yakov Smirnoff appeared in the cold open. ||||
| 1,870 | February 10, 2014 (2014-02-10) | Julie Chen, Bubba Watson | N/A |
| 1,871 | February 11, 2014 (2014-02-11) | Jason Alexander, Regina Hall | N/A |
| 1,872 | February 12, 2014 (2014-02-12) | Kurt Russell, Aimee Garcia | N/A |
| 1,873 | February 13, 2014 (2014-02-13) | Matt LeBlanc, Abbie Cornish | N/A |
| 1,874 | February 14, 2014 (2014-02-14) | Elizabeth Banks | Chris Voth |
| 1,875 | February 17, 2014 (2014-02-17) | Gary Oldman, Ellie Kemper | Roddy Hart and The Lonesome Fire |
| 1,876 | February 18, 2014 (2014-02-18) | Ted Danson, Kristen Schaal | N/A |
| 1,877 | February 19, 2014 (2014-02-19) | Kevin Costner, Krystal Keith | Tony Deyo |
| 1,878 | February 20, 2014 (2014-02-20) | Joseph Gordon-Levitt, Lisa Vanderpump | N/A |
| 1,879 | February 21, 2014 (2014-02-21) | Ken Jeong, Léa Seydoux | N/A |
| 1,880 | February 24, 2014 (2014-02-24) | Zooey Deschanel, Vera Farmiga | Roddy Hart and The Lonesome Fire |
| Julia Mancuso appeared in the cold open. ||||
| 1,881 | February 25, 2014 (2014-02-25) | Ashton Kutcher | Roddy Hart and The Lonesome Fire |
| 1,882 | February 26, 2014 (2014-02-26) | Alice Eve, Bojana Novakovic | Roddy Hart and The Lonesome Fire |
| Taylor Hicks appeared in the cold open. ||||
| 1,883 | February 27, 2014 (2014-02-27) | Julia Stiles, Dave Itzkoff | Roddy Hart and The Lonesome Fire |
| 1,884 | February 28, 2014 (2014-02-28) | Sarah Chalke | Roddy Hart and The Lonesome Fire |

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,885 | March 3, 2014 (2014-03-03) | Meredith Vieira, Josh Radnor | N/A |
| 1,886 | March 4, 2014 (2014-03-04) | Elijah Wood, Keke Palmer | Glasvegas |
| 1,887 | March 5, 2014 (2014-03-05) | Carson Kressley, Lena Headey | Panic! at the Disco |
| 1,888 | March 6, 2014 (2014-03-06) | Rosie Perez | Bryan Kellen |
| 1,889 | March 7, 2014 (2014-03-07) | Aaron Paul | Andi Osho |
| 1,890 | March 10, 2014 (2014-03-10) | Emily Mortimer, Darrin Rose | The Alternate Routes |
| 1,891 | March 11, 2014 (2014-03-11) | Jeff Goldblum, Lauren Cohan | N/A |
| 1,892 | March 12, 2014 (2014-03-12) | Ricky Gervais, Lauren Cohan | N/A |
| 1,893 | March 13, 2014 (2014-03-13) | Kristen Bell, Michael McMillian | N/A |
| 1,894 | March 14, 2014 (2014-03-14) | Amy Smart, Denise Mina | N/A |
| 1,895 | March 17, 2014 (2014-03-17) | Jane Lynch, Salman Rushdie | N/A |
| Drew Carey appears in cold open ||||
| 1,896 | March 18, 2014 (2014-03-18) | Lewis Black, Dawn Olivieri | N/A |
| 1,897 | March 19, 2014 (2014-03-19) | Uma Thurman, DJ Qualls | N/A |
| 1,898 | March 24, 2014 (2014-03-24) | Betty White, Brett Dalton | N/A |
| 1,899 | March 25, 2014 (2014-03-25) | Howie Mandel, Ginger Gonzaga | The Belle Brigade |
| 1,900 | March 26, 2014 (2014-03-26) | Scarlett Johansson | Maz Jobrani |
| 1,901 | March 31, 2014 (2014-03-31) | Carl Reiner, Connie Schultz | Joan Jett & The Blackhearts |
| As part of an April Fool's Day staff swap with The Price Is Right, Drew Carey hosted with four sidekicks -- George Gray, Rachel Reynolds, Amber Lancaster and Manuela Arbeláez. Ferguson, Stevens, and "Secretariat" were on Price hours later. ||||

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,902 | April 7, 2014 (2014-04-07) | Cat Deeley, Gina Carano | N/A |
| 1,903 | April 8, 2014 (2014-04-08) | Jon Hamm, Pam Dawber | N/A |
| 1,904 | April 9, 2014 (2014-04-09) | Sharon Osbourne, Tony Kanaan | N/A |
| 1,905 | April 10, 2014 (2014-04-10) | Morgan Freeman | Adam Ray |
| 1,906 | April 11, 2014 (2014-04-11) | Wanda Sykes, Malin Akerman | N/A |
| 1,907 | April 14, 2014 (2014-04-14) | Dominic Monaghan, Brooklyn Decker | N/A |
| 1,908 | April 15, 2014 (2014-04-15) | Wendie Malick, Jim Rash | N/A |
| 1,909 | April 16, 2014 (2014-04-16) | Kunal Nayyar | Tom Segura |
| 1,910 | April 17, 2014 (2014-04-17) | Kevin Bacon | Andy Hendrickson |
| 1,911 | April 18, 2014 (2014-04-18) | William Shatner, Jaime Pressly | N/A |
| 1,912 | April 21, 2014 (2014-04-21) | George Lopez, Ari Graynor | N/A |
| 1,913 | April 22, 2014 (2014-04-22) | Cedric the Entertainer, Billie Piper | N/A |
| 1,914 | April 23, 2014 (2014-04-23) | Eddie Izzard, Lyle Lovett | N/A |
| 1,915 | April 24, 2014 (2014-04-24) | Emily Deschanel, Zoe Lister-Jones | N/A |
| 1,916 | April 25, 2014 (2014-04-25) | Billy Bob Thornton | St. Paul & the Broken Bones |
| 1,917 | April 28, 2014 (2014-04-28) | Candice Accola, LL Cool J | N/A |
| Craig announces he is leaving The Late Late Show at the end of the year. ||||
| 1,918 | April 29, 2014 (2014-04-29) | Valerie Bertinelli, Seth Gabel | N/A |
| 1,919 | April 30, 2014 (2014-04-30) | Jim Gaffigan | N/A |

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,920 | May 1, 2014 (2014-05-01) | Cheryl Hines, Rampage Jackson | N/A |
| 1,921 | May 2, 2014 (2014-05-02) | Christiane Amanpour, Rachael Taylor | N/A |
| 1,922 | May 5, 2014 (2014-05-05) | Elisabeth Moss, Tom Felton | N/A |
| 1,923 | May 6, 2014 (2014-05-06) | Colin Hanks, Richard Ayoade | N/A |
| 1,924 | May 7, 2014 (2014-05-07) | Patton Oswalt, Megan Boone | N/A |
| 1,925 | May 8, 2014 (2014-05-08) | Lisa Kudrow | N/A |
| 1,926 | May 9, 2014 (2014-05-09) | Eugenio Derbez, Elizabeth Henstridge | A Great Big World |
| 1,927 | May 12, 2014 (2014-05-12) | Angela Kinsey, Samantha Shannon | N/A |
| 1,928 | May 13, 2014 (2014-05-13) | Billy Gardell, Lennon Parham, James Galea | N/A |
| 1,929 | May 14, 2014 (2014-05-14) | Carrie Ann Inaba, Anthony Horowitz | N/A |
| 1,930 | May 15, 2014 (2014-05-15) | Jenna Elfman, Bianca Kajlich | N/A |
| 1,931 | May 16, 2014 (2014-05-16) | Sophia Bush, Jackie Collins | N/A |
| 1,932 | May 19, 2014 (2014-05-19) | Regis Philbin | Jamestown Revival |
| 1,933 | May 20, 2014 (2014-05-20) | Terry Bradshaw, Jessica McNamee | N/A |
| 1,934 | May 21, 2014 (2014-05-21) | Jeff Foxworthy | The Colourist |
| 1,935 | May 22, 2014 (2014-05-22) | Tom Lennon, Bob Oschack | 2Cellos |
| 1,936 | May 23, 2014 (2014-05-23) | Jon Favreau, Carrie Keagan | N/A |
| 1,937 | May 26, 2014 (2014-05-26) | Shailene Woodley | Dan Boulger, Wild Child |
| 1,938 | May 27, 2014 (2014-05-27) | Betty White, Richard Quest | Jamestown Revival |
| 1,939 | May 28, 2014 (2014-05-28) | America Ferrera, Honeysuckle Weeks | N/A |
| 1,940 | May 29, 2014 (2014-05-29) | Hugh Laurie | Hugh Laurie |
| 1,941 | May 30, 2014 (2014-05-30) | William Shatner, Jessica St. Clair | N/A |

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,942 | June 2, 2014 (2014-06-02) | Bob Newhart, Constance Zimmer | N/A |
| 1,943 | June 3, 2014 (2014-06-03) | Amanda Peet, Kit Harington | N/A |
| 1,944 | June 4, 2014 (2014-06-04) | Susan Sarandon, Garrison Keillor | N/A |
| 1,945 | June 5, 2014 (2014-06-05) | John Waters, Yunjin Kim | N/A |
| 1,946 | June 6, 2014 (2014-06-06) | Ricky Gervais | Keb' Mo' |
| 1,947 | June 9, 2014 (2014-06-09) | Bob Saget, Ashley Madekwe | N/A |
| 1,948 | June 10, 2014 (2014-06-10) | Megan Mullally, T.J. Miller | N/A |
| 1,949 | June 11, 2014 (2014-06-11) | Jay Baruchel, Regina Hall | N/A |
| 1,950 | June 12, 2014 (2014-06-12) | Michelle Monaghan, Greg Proops | N/A |
| 1,951 | June 13, 2014 (2014-06-13) | Max Greenfield | Ben & Ellen Harper |
| 1,952 | June 16, 2014 (2014-06-16) | Henry Winkler, Lennon Parham | N/A |
| 1,953 | June 17, 2014 (2014-06-17) | Simon Helberg | LP |
| 1,954 | June 18, 2014 (2014-06-18) | Noah Wyle, Abigail Spencer | N/A |
| 1,955 | June 19, 2014 (2014-06-19) | Carson Kressley, Shantel VanSanten | N/A |
| 1,956 | June 20, 2014 (2014-06-20) | Maria Bello, Bradley Trevor Greive | N/A |
| 1,957 | June 23, 2014 (2014-06-23) | Kathy Bates, Joel Stein | N/A |
| 1,958 | June 24, 2014 (2014-06-24) | David Sedaris | Mindy Rickles |
| 1,959 | June 25, 2014 (2014-06-25) | Alfred Molina, Moon Bloodgood | N/A |
| 1,960 | June 26, 2014 (2014-06-26) | Jane Lynch, Keke Palmer | N/A |
| 1,961 | June 27, 2014 (2014-06-27) | Ice-T, Mackenzie Davis | Body Count |

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,962 | July 7, 2014 (2014-07-07) | Kathy Griffin | Ingrid Michaelson |
| 1,963 | July 8, 2014 (2014-07-08) | Tim Meadows | N/A |
| 1,964 | July 9, 2014 (2014-07-09) | Michael Sheen | N/A |
| 1,965 | July 10, 2014 (2014-07-10) | Carl Reiner, Valerie Azlynn | N/A |
| 1,966 | July 14, 2014 (2014-07-14) | Margaret Cho, Zachary Levi | N/A |
| 1,967 | July 15, 2014 (2014-07-15) | Nicole Richie, Nat Faxon | Mark Forward |
| 1,968 | July 16, 2014 (2014-07-16) | Elijah Wood, Marcia Clark | Kristeen Young with Dave Grohl and Pat Smear |
| 1,969 | July 17, 2014 (2014-07-17) | Julia Ormond, Dan Riskin | N/A |
| 1,970 | July 18, 2014 (2014-07-18) | Aisha Tyler, Nat Faxon | N/A |
| 1,971 | July 21, 2014 (2014-07-21) | Octavia Spencer, Brad Goreski | N/A |
| 1,972 | July 22, 2014 (2014-07-22) | Regis Philbin, Irina Shayk | Switchfoot |
| 1,973 | July 23, 2014 (2014-07-23) | Larry King | N/A |
| 1,974 | July 24, 2014 (2014-07-24) | David Duchovny | Gloria Estefan |
| 1,975 | July 25, 2014 (2014-07-25) | Bradley Cooper, Lisa Joyce | N/A |
| 1,976 | July 28, 2014 (2014-07-28) | Olivia Williams | Josh Wolf |
| 1,977 | July 29, 2014 (2014-07-29) | Simon Pegg, Jamie Chung | N/A |
| 1,978 | July 30, 2014 (2014-07-30) | Dana Carvey, Brit Marling | N/A |
| 1,979 | July 31, 2014 (2014-07-31) | Jesse Tyler Ferguson, Jón Gnarr | N/A |

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,980 | August 1, 2014 (2014-08-01) | Cat Deeley, Marcia Clark | N/A |
| 1,981 | August 4, 2014 (2014-08-04) | Guy Pearce | Andi Osho |
| 1,982 | August 5, 2014 (2014-08-05) | Diane Kruger | Brad Trackman |
| 1,983 | August 6, 2014 (2014-08-06) | Kelsey Grammer, Sloane Crosley | N/A |
| 1,984 | August 7, 2014 (2014-08-07) | Breckin Meyer, Morena Baccarin | N/A |
| 1,985 | August 8, 2014 (2014-08-08) | Daniel Radcliffe | Cathy Ladman |

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1,986 | September 1, 2014 (2014-09-01) | Ray Liotta, Annaleigh Ashford | N/A |
| 1,987 | September 2, 2014 (2014-09-02) | Carrot Top, Gwendoline Christie | Comedian Carrot Top |
| 1,988 | September 3, 2014 (2014-09-03) | David Arquette, Inbar Lavi | N/A |
| 1,989 | September 4, 2014 (2014-09-04) | Rachael Ray | Ted Alexandro |
| 1,990 | September 5, 2014 (2014-09-05) | Seth Green, journalist Lynette Rice | N/A |
| 1,991 | September 8, 2014 (2014-09-08) | Katey Sagal, Michael Irvin | N/A |
| 1,992 | September 9, 2014 (2014-09-09) | Julie Chen, Louie Anderson | N/A |
| 1,993 | September 10, 2014 (2014-09-10) | Cheryl Hines, Lawrence Block | N/A |
| 1,994 | September 11, 2014 (2014-09-11) | Wendie Malick, Ben Mezrich | N/A |
| 1,995 | September 12, 2014 (2014-09-12) | Nikki Reed, Peter May | Nikki Reed and Paul McDonald |
| 1,996 | September 15, 2014 (2014-09-15) | Kevin Bacon, Michael Bacon | The Bacon Brothers |
| 1,997 | September 16, 2014 (2014-09-16) | Terry Bradshaw, Joel Stein | N/A |
| 1,998 | September 17, 2014 (2014-09-17) | Paul Reiser, Aimee Garcia | N/A |
| 1,999 | September 18, 2014 (2014-09-18) | Sharon Osbourne | Comedienne Carmen Lynch |
| 2,000 | September 19, 2014 (2014-09-19) | Morgan Freeman, Genesis Rodriguez | N/A |
| 2,001 | September 22, 2014 (2014-09-22) | Bill Hader, Scott Bakula | N/A |
| 2,002 | September 23, 2014 (2014-09-23) | Lauren Graham, Ed Weeks | N/A |
| 2,003 | September 24, 2014 (2014-09-24) | Judd Apatow, Jackie Guerrido | N/A |
| 2,004 | September 25, 2014 (2014-09-25) | Mel B, Ben Schwartz | N/A |
| 2,005 | September 26, 2014 (2014-09-26) | Ben Kingsley, Bojana Novakovic | N/A |
| 2,006 | September 29, 2014 (2014-09-29) | Jim Gaffigan | Wolfgang Puck |
| 2,007 | September 30, 2014 (2014-09-30) | Don Rickles, Eiza González | Daniel Sloss |

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 2,008 | October 1, 2014 (2014-10-01) | Patton Oswalt, Chandra Wilson | N/A |
| 2,009 | October 2, 2014 (2014-10-02) | Joe Theismann, Lauren Cohan | N/A |
| 2,010 | October 3, 2014 (2014-10-03) | Nick Lachey, Chloe Bennet | N/A |
| 2,011 | October 13, 2014 (2014-10-13) | Carson Kressley, Rampage Jackson | N/A |
| 2,012 | October 14, 2014 (2014-10-14) | James Marsden, Kristen Schaal | N/A |
| 2,013 | October 15, 2014 (2014-10-15) | Zoe Saldana, T.J. Miller | N/A |
| 2,014 | October 16, 2014 (2014-10-16) | Joshua Jackson, Kara Cooney | N/A |
| 2,015 | October 17, 2014 (2014-10-17) | Sean Hayes, "Weird Al" Yankovic | "Weird Al" Yankovic performs "Lame Claim to Fame" from Mandatory Fun |
| 2,016 | October 20, 2014 (2014-10-20) | Sarah Paulson, Jim Rash | N/A |
| 2,017 | October 21, 2014 (2014-10-21) | Pierce Brosnan, Krysten Ritter | N/A |
| 2,018 | October 22, 2014 (2014-10-22) | Jason Schwartzman, Jacqueline Toboni | N/A |
| 2,019 | October 23, 2014 (2014-10-23) | Shailene Woodley | N/A |
| 2,020 | October 24, 2014 (2014-10-24) | Tenacious D, Jack McGee | Tenacious D perform "Classico" from The Pick of Destiny |
| 2,021 | October 27, 2014 (2014-10-27) | Ray Romano, Tessa Thompson | N/A |
| 2,022 | October 28, 2014 (2014-10-28) | Quentin Tarantino, Toni Trucks | N/A |
| 2,023 | October 29, 2014 (2014-10-29) | Justin Long, Angélica Celaya | N/A |
| 2,024 | October 30, 2014 (2014-10-30) | Cedric the Entertainer, Jayma Mays | N/A |
| 2,025 | October 31, 2014 (2014-10-31) | Ted Danson | Alingon Mitra |

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 2,026 | November 3, 2014 (2014-11-03) | Joel McHale | N/A |
| 2,027 | November 5, 2014 (2014-11-05) | Bob Newhart, Melissa Rauch | N/A |
| 2,028 | November 6, 2014 (2014-11-06) | Marion Cotillard, Ross Matthews | N/A |
| 2,029 | November 7, 2014 (2014-11-07) | Jimmy Kimmel, Yvette Nicole Brown | N/A |
| 2,030 | November 10, 2014 (2014-11-10) | Eric Idle, David Tennant | Parmalee |
| 2,031 | November 11, 2014 (2014-11-11) | Valerie Bertinelli, James Oswald | N/A |
| 2,032 | November 12, 2014 (2014-11-12) | Steven Wright, Michaela Conlin | N/A |
| 2,033 | November 13, 2014 (2014-11-13) | Simon Helberg, Gillian Jacobs | N/A |
| 2,034 | November 14, 2014 (2014-11-14) | Jeff Daniels, Paula Poundstone | N/A |
| 2,035 | November 17, 2014 (2014-11-17) | Metallica appeared all week as an artist in residency, Max Greenfield |
| 2,036 | November 18, 2014 (2014-11-18) | Jane Lynch |
| 2,037 | November 19, 2014 (2014-11-19) | Malin Akerman, Claire Holt |
| 2,038 | November 20, 2014 (2014-11-20) | Matthew McConaughey, Frank Nicotero |
| 2,039 | November 21, 2014 (2014-11-21) | Cillian Murphy, Jennifer Carpenter |
| 2,040 | November 24, 2014 (2014-11-24) | William Shatner | Erin Foley |
| 2,041 | November 25, 2014 (2014-11-25) | Kristin Chenoweth, Michael Ealy | N/A |
| 2,042 | November 26, 2014 (2014-11-26) | Wayne Brady, Alison Becker | N/A |
| 2,043 | November 28, 2014 (2014-11-28) | Kat Dennings | Jermaine Fowler |

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 2,044 | December 1, 2014 (2014-12-01) | Lisa Kudrow, Dominic Monaghan | N/A |
| 2,045 | December 2, 2014 (2014-12-02) | Ariel Tweto, Henry Winkler | N/A |
| 2,046 | December 3, 2014 (2014-12-03) | Don Cheadle, Mary McCormack | N/A |
| 2,047 | December 4, 2014 (2014-12-04) | Drew Carey, Max Greenfield | N/A |
| 2,048 | December 5, 2014 (2014-12-05) | Kristen Bell, Steve Carell | N/A |
| 2,049 | December 8, 2014 (2014-12-08) | Carrie Fisher, Dave Attell, Eddie Izzard | N/A |
| It's the Geoff Peterson-free show. Josh Robert Thompson is unavailable for the episode and Craig calls Secretariat into service as his sidekick for the evening. ||||
| 2,050 | December 9, 2014 (2014-12-09) | Michael Sheen, Ben Schwartz | N/A |
| 2,051 | December 10, 2014 (2014-12-10) | Mila Kunis, Bob Saget | N/A |
| 2,052 | December 11, 2014 (2014-12-11) | Kunal Nayyar, Sarah Chalke | N/A |
| 2,053 | December 12, 2014 (2014-12-12) | Rashida Jones, DJ Qualls | N/A |
| 2,054 | December 15, 2014 (2014-12-15) | Jon Hamm, Tim Meadows | N/A |
| 2,055 | December 16, 2014 (2014-12-16) | Larry King, Angela Kinsey | N/A |
| 2,056 | December 17, 2014 (2014-12-17) | Betty White, Thomas Lennon | N/A |
| James Corden appeared in the cold open and discussed his taking over the program in March. ||||
| 2,057 | December 18, 2014 (2014-12-18) | Jim Parsons | N/A |
| Josh Robert Thompson, who voices Geoff Peterson and other characters, appeared as himself in the cold open. ||||
| 2,058 | December 19, 2014 (2014-12-19) | Jay Leno | N/A |
| Craig's final show starts with the usual cold open, but this time showing a montage of friends from the show performing Dead Man Fall's song "Bang Your Drum." Some are shown lip-synching to the song, while others are shown carrying and playing a large bass drum. Cameos in the montage include: Kevin Bacon and Kyra Sedgwick (plus dog Lily), Kristen Bell (plus daughter Delta Bell as "drum", 14 days before birth), Pierce Brosnan, Steve Carell, Don Cheadle, Kristin Chenoweth, Marion Cotillard, Tenacious D, Jeff Daniels, Ted Danson, Kat Dennings, Julia Louis-Dreyfus and Tony Hale, Carl Edwards, Cedric the Entertainer, Jon Hamm, Sean Hayes, Samuel L. Jackson, Rashida Jones, Toby Keith, Jimmy Kimmel, Larry King, Angela Kinsey, Mila Kunis, Lisa Kudrow, Thomas Lennon, Jane Lynch, Justin Long, James Marsden, Matthew McConaughey, Mary McCormack (plus the rattlesnake mug she gifted Ferguson), Joel McHale, Tim Meadows, Metallica, Kunal Nayyar, Geoff Peterson, Regis Philbin, Ray Romano, Bob Saget, William Shatner, Michael Sheen, Quentin Tarantino, Josh Robert Thompson, Archbishop Desmond Tutu, Betty White, Henry Winkler, Shailene Woodley, "Weird Al" Yankovic, Late Late Show Puppets and others. The pre-taped (35 of the cameos were guests taped at their final Late Late Show appearances, from Marsden on October 14 to White and Lennon on December 17) montage segued to the studio with Ferguson continuing the song backed by the occasional semi-house band Bone Patrol, Sex Pistols guitarist Steve Jones a full choir, various celebrities, musicians and friends of the show. The monologue begins with a short time lapse of Craig coming out to start show through the last 10 years, starting on his first day (January 3, 2005) to his last day (December 19, 2014). Craig thanks his comedic partner Josh Robert Thompson, the viewers, the crew, and explains "Over the years, going with this show out and around, or going and doing stand-up with Josh, I've come into contact with a lot of people who are viewers of this show, and although I said my goodbyes to the crew, the people who made this show are you. You came to a show that, let's be honest, a bit of a fixer upper. It kind of stayed that way, but what I hope we've done ... maybe art is a very grand word, but I think what we managed to do here is make something that wasn't here before. So in that sense maybe it is a piece of art, it didn't exist and now it does. What we've done here, it doesn't go away because I stopped doing it, we stop doing this and we start doing something else ... maybe ... later, or maybe I go away and this is it! But I think what was more overwhelming than anything else in the experience of doing this show was making a connection with a country which I became a part of, which is astonishing to me. Even in the course of this show I became an American, officially and particularly for my friends at the IRS, I am now a fully fledged American. However, what I can't be is a member of a club, which I didn't really ask to join, I wanted to do this show ... and now we've done this show, and if you will indulge me in whatever I'm doing now and come to whatever I do next I'd be very grateful, because my kids are still young." After reading his last Tweets & E-mails and doing his final interview with guest Jay Leno, the show ends with his final segment: What Did We Learn on the Show Over the Last 10 Years Craig? Craig tells Geoff he wants to finally find out who the real identity of Secretariat is. Asked to lift up his mask, it's revealed to be Bob Newhart. Craig asks, "Bob Newhart?! What are you doing here?" To which he replies, "Hey man it's your dream." Craig wakes up next to Drew Carey as Nigel Wick and proceed to spoof the finales of Newhart (the show was all a dream), St. Elsewhere (he imagined it all from a snowglobe) and The Sopranos (cut to black with Journey's Don't Stop Believin'). ||||