# Serena Williams career statistics

This is a list of the main career statistics of professional American tennis player Serena Williams.

## Performance timelines

Key :
| W | F | SF | QF | #R | RR | Q# | P# | DNQ | A | Z# | PO | G | S | B | NMS | NTI | P | NH |

### Singles

Current through the 2022 WTA Tour.
| Tournament | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | SR | W–L | Win% |
| Grand Slam tournaments ||||||||||||||||||||||||||||||||
| Australian Open | A | A | A | 2R | 3R | 4R | QF | A | W | A | W | 3R | W | QF | W | W | A | 4R | QF | 4R | W | F | W | A | QF | 3R | SF | A | 7 / 20 | 92–13 | 88% |
| French Open | A | A | A | 4R | 3R | A | QF | W | SF | QF | A | A | QF | 3R | QF | QF | A | 1R | W | 2R | W | F | A | 4R | 3R | 2R | 4R | A | 3 / 19 | 69–14 | 83% |
| Wimbledon | A | A | A | 3R | A | SF | QF | W | W | F | 3R | A | QF | F | W | W | 4R | W | 4R | 3R | W | W | A | F | F | NH | 1R | 1R | 7 / 21 | 98–14 | 88% |
| US Open | A | A | A | 3R | W | QF | F | W | A | QF | 4R | 4R | QF | W | SF | A | F | W | W | W | SF | SF | A | F | F | SF | A | 3R | 6 / 21 | 108–15 | 88% |
| Win–loss | 0–0 | 0–0 | 0–0 | 8–4 | 11–2 | 12–3 | 18–4 | 21–0 | 19–1 | 14–3 | 12–2 | 5–2 | 19–3 | 19–3 | 23–2 | 18–1 | 9–2 | 17–2 | 21–2 | 13–3 | 26–1 | 24–3 | 7–0 | 15–2 | 18–4 | 8–2 | 8–3 | 2–2 | 23 / 81 | 367–56 | 87% |
| Year-end championships ||||||||||||||||||||||||||||||||
| WTA Finals | did not qualify | did not qualify | did not qualify | did not qualify | A | A | W | F | A | F | DNQ | DNQ | RR | RR | W | A | DNQ | W | W | W | A | A | DNQ | DNQ | DNQ | NH | DNQ | DNQ | 5 / 9 | 29–6 | 83% |
| Grand Slam Cup | men's only event | men's only event | men's only event | DNQ | W | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | 1 / 1 | 3–0 | 100% |
| National representation ||||||||||||||||||||||||||||||||
| Summer Olympics | NH | A | not held | not held | not held | A | not held | not held | not held | A | not held | not held | not held | QF | not held | not held | not held | G | not held | not held | not held | 3R | not held | not held | not held | not held | A | NH | 1 / 3 | 11–2 | 85% |
| Billie Jean King Cup | A | A | A | A | W | A | A | A | F | A | A | A | SF | A | A | A | A | PO | PO | A | PO | A | A | F | A | QR | A | A | 1 / 4 | 14–1 | 93% |
| WTA 1000 / Premier Mandatory & Premier 5 / former Tier I tournaments ||||||||||||||||||||||||||||||||
| Dubai / Qatar Open | not held | not held | not held | not held | not held | not held | Tier III | Tier III | Tier III | Tier II | Tier II | Tier II | Tier II | A | SF | A | A | A | F | A | A | A | A | A | A | A | A | A | 0 / 2 | 7–2 | 78% |
| Indian Wells Open | TII | A | Q1 | A | W | QF | W | absent | absent | absent | absent | absent | absent | absent | absent | absent | absent | absent | absent | absent | SF | F | A | 3R | 3R | NH | A | A | 2 / 7 | 26–4 | 87% |
| Miami Open | A | A | A | QF | F | 4R | QF | W | W | W | QF | A | W | W | F | A | A | QF | W | W | W | 4R | A | 1R | 3R | NH | A | A | 8 / 18 | 76–9 | 89% |
| Madrid Open | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | 1R | 3R | A | W | W | QF | SF | A | A | A | A | NH | A | A | 2 / 6 | 20–3 | 87% |
| Italian Open | A | A | A | QF | QF | A | A | W | SF | SF | 2R | A | QF | QF | 2R | SF | A | SF | W | W | 3R | W | A | A | 2R | A | 2R | A | 4 / 17 | 44–9 | 83% |
| Canadian Open | A | A | A | A | A | F | W | A | A | A | 3R | A | A | A | SF | A | W | A | W | SF | SF | A | A | A | F | NH | A | 2R | 3 / 10 | 35–6 | 85% |
| Cincinnati Open | not held | not held | not held | not held | not held | not held | not held | not held | not held | Tier III | Tier III | Tier III | Tier III | Tier III | 3R | A | 2R | QF | F | W | W | A | A | 2R | A | 3R | A | 1R | 2 / 9 | 20–6 | 77% |
| Wuhan Open | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | 2R | A | A | A | A | A | not held | not held | not held | 0 / 1 | 0–1 | 0% |
| China Open | not held | not held | not held | not held | not held | not held | not held | not held | not held | Tier II | Tier II | Tier II | Tier II | Tier II | 3R | A | A | A | W | QF | A | A | A | A | A | not held | not held | not held | 1 / 3 | 11–1 | 92% |
| Charleston Open | A | A | A | A | A | A | A | QF | F | 3R | A | A | 1R | W | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | Premier / WTA 500 | 1 / 5 | 12–3 | 80% |
| German Open | A | A | A | A | QF | A | A | F | A | A | A | A | A | QF | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | WTA 500 | WTA 500 | 0 / 3 | 7–3 | 70% |
| Sn. California Open | Tier II | Tier II | Tier II | Tier II | Tier II | Tier II | Tier II | Tier II | Tier II | QF | A | A | A | not held | not held | Premier | Premier | Premier | Premier | not held | not held | not held | not held | not held | not held | not held | not held | not held | 0 / 1 | 2–0 | 100% |
| Zurich Open | A | A | Q2 | A | A | A | A | A | A | A | A | A | 1R | TII | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | 0 / 1 | 0–1 | 0% |
| Kremlin Cup | NH | TIII | 1R | A | A | A | A | A | A | A | A | A | F | A | Premier | Premier | Premier | Premier | Premier | Premier | Premier | Premier | Premier | Premier | Premier | NH | 500 | NH | 0 / 2 | 3–2 | 60% |
| Win–loss | 0–0 | 0–0 | 0–1 | 7–2 | 15–3 | 9–3 | 13–1 | 16–2 | 13–2 | 12–1 | 4–2 | 0–0 | 11–4 | 15–1 | 14–7 | 4–2 | 7–0 | 15–2 | 36–2 | 25–2 | 23–2 | 12–2 | 0–0 | 3–3 | 7–2 | 1–1 | 0–1 | 1–2 | 23 / 85 | 263–50 | 84% |
| Career statistics ||||||||||||||||||||||||||||||||
| | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | SR | W–L | Win% |
| Tournaments | 0 | 0 | 2 | 11 | 12 | 11 | 10 | 13 | 7 | 12 | 10 | 4 | 12 | 13 | 16 | 6 | 6 | 13 | 15 | 16 | 11 | 8 | 2 | 7 | 8 | 6 | 6 | 4 | Career total: 240 | Career total: 240 | Career total: 240 |
| Titles | 0 | 0 | 0 | 0 | 5 | 3 | 3 | 8 | 4 | 2 | 1 | 0 | 2 | 4 | 3 | 2 | 2 | 7 | 11 | 7 | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | Career total: 73 | Career total: 73 | Career total: 73 |
| Finals | 0 | 0 | 0 | 0 | 6 | 5 | 4 | 10 | 5 | 5 | 1 | 0 | 3 | 5 | 4 | 3 | 3 | 7 | 13 | 7 | 5 | 5 | 1 | 2 | 3 | 1 | 0 | 0 | Career total: 98 | Career total: 98 | Career total: 98 |
| Hardcourt W–L | 0–0 | 0–0 | 0–0 | 16–7 | 29–4 | 25–5 | 27–5 | 28–3 | 19–0 | 23–5 | 17–4 | 12–4 | 25–6 | 27–5 | 39–8 | 10–1 | 18–1 | 28–3 | 47–3 | 41–5 | 30–2 | 20–5 | 8–1 | 9–5 | 16–4 | 16–5 | 8–1 | 3–3 | 48 / 149 | 541–95 | 85% |
| Clay W–L | 0–0 | 0–0 | 0–0 | 6–2 | 7–3 | 0–1 | 4–1 | 17–2 | 12–3 | 10–3 | 2–2 | 0–0 | 6–3 | 11–2 | 4–4 | 8–3 | 0–0 | 17–1 | 28–0 | 9–2 | 16–1 | 11–1 | 0–0 | 3–0 | 3–1 | 1–0 | 4–3 | 0–0 | 13 / 60 | 179–38 | 82% |
| Grass W–L | 0–0 | 0–0 | 0–0 | 4–2 | 0–0 | 5–1 | 4–1 | 7–0 | 7–0 | 6–1 | 2–1 | 0–0 | 4–1 | 6–1 | 7–0 | 7–0 | 4–2 | 13–0 | 3–1 | 2–1 | 7–0 | 7–0 | 0–0 | 6–1 | 6–1 | 0–0 | 0–1 | 0–1 | 8 / 24 | 107–16 | 87% |
| Carpet W–L | 0–0 | 0–0 | 3–2 | 0–0 | 5–0 | 7–1 | 3–0 | 4–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | discontinued | 4 / 7 | 22–3 | 88% |
| Outdoor W–L | 0–0 | 0–0 | 0–0 | 22–9 | 33–6 | 30–7 | 35–7 | 49–4 | 32–3 | 36–6 | 20–7 | 12–4 | 30–6 | 44–7 | 47–12 | 25–4 | 22–3 | 51–4 | 73–4 | 48–7 | 53–3 | 38–6 | 8–1 | 18–6 | 25–6 | 16–4 | 12–5 | 3–4 | 64 / 216 | 782–135 | 85% |
| Indoor W–L | 0–0 | 0–0 | 3–2 | 4–2 | 8–1 | 7–1 | 3–0 | 7–1 | 6–0 | 3–3 | 1–0 | 0–0 | 5–4 | 0–1 | 3–0 | 0–0 | 0–0 | 7–0 | 5–0 | 4–1 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 1–1 | 0–0 | 0–0 | 9 / 24 | 67–17 | 80% |
| Overall win–loss | 0–0 | 0–0 | 3–2 | 26–11 | 41–7 | 37–8 | 38–7 | 56–5 | 38–3 | 39–9 | 21–7 | 12–4 | 35–10 | 44–8 | 50–12 | 25–4 | 22–3 | 58–4 | 78–4 | 52–8 | 53–3 | 38–6 | 8–1 | 18–6 | 25–6 | 17–5 | 12–5 | 3–4 | 73 / 240 | 849–152 | 85% |
| Win % | – | – | 60% | 70% | 85% | 82% | 84% | 92% | 93% | 81% | 75% | 75% | 78% | 85% | 81% | 86% | 88% | 94% | 95% | 87% | 95% | 86% | 89% | 75% | 81% | 77% | 71% | 43% | 85% | 85% | 85% |
| Year-end ranking | – | – | 99 | 20 | 4 | 6 | 6 | 1 | 3 | 7 | 11 | 95 | 7 | 2 | 1 | 4 | 12 | 3 | 1 | 1 | 1 | 2 | 22 | 16 | 10 | 11 | 41 | 320 | $94,816,730 | $94,816,730 | $94,816,730 |

### Doubles

| Tournament | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | SR | W–L | Win% |
| Grand Slam tournaments ||||||||||||||||||||||||||||||
| Australian Open | A | 3R | SF | A | W | A | W | A | A | A | A | QF | W | W | A | A | QF | A | A | A | A | A | A | A | A | A | 4 / 8 | 36–4 | 90% |
| French Open | A | A | W | A | A | A | A | A | A | A | A | A | 3R | W | A | A | 1R | A | A | 3R | A | 3R | A | A | A | A | 2 / 6 | 17–3 | 85% |
| Wimbledon | A | 1R | A | W | 3R | W | 3R | A | A | A | 2R | W | W | QF | A | W | A | 2R | A | W | A | A | A | NH | A | A | 6 / 12 | 45–3 | 94% |
| US Open | 1R | A | W | SF | 3R | A | A | A | A | A | A | A | W | A | A | 3R | SF | QF | A | A | A | A | A | A | A | 1R | 2 / 9 | 27–6 | 82% |
| Win–loss | 0–1 | 2–1 | 16–1 | 10–0 | 10–1 | 6–0 | 8–1 | 0–0 | 0–0 | 0–0 | 1–0 | 9–1 | 20–1 | 14–1 | 0–0 | 8–1 | 7–2 | 4–2 | 0–0 | 8–1 | 0–0 | 2–1 | 0–0 | 0–0 | 0–0 | 0–1 | 14 / 35 | 125–16 | 89% |
| Year-end championship ||||||||||||||||||||||||||||||
| WTA Finals | DNQ | DNQ | A | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | SF | A | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | did not qualify | NH | DNQ | DNQ | 0 / 1 | 0–1 | 0% |
| National representation ||||||||||||||||||||||||||||||
| Olympics | not held | not held | not held | G | not held | not held | not held | A | not held | not held | not held | G | not held | not held | not held | G | not held | not held | not held | 1R | not held | not held | not held | not held | A | NH | 3 / 4 | 15–1 | 94% |
| Billie Jean King Cup | A | A | W | A | A | A | F | A | A | A | SF | A | A | A | A | PO | PO | A | PO | A | A | F | A | QR | A | A | 1 / 4 | 3–2 | 60% |
| WTA 1000 / Premier Mandatory & Premier 5 / former Tier I tournaments ||||||||||||||||||||||||||||||
| Indian Wells Open | QF | QF | SF | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | NH | A | A | 0 / 3 | 7–3 | 70% |
| Miami Open | A | 1R | 3R | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | NH | A | A | 0 / 2 | 1–1 | 50% |
| Madrid Open | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | not held | A | W | A | A | A | A | A | A | A | A | A | NH | A | A | 1 / 1 | 4–0 | 100% |
| Italian Open | A | SF | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | A | 1R | A | A | A | A | A | A | 0 / 2 | 3–2 | 60% |
| China Open | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | A | A | A | A | 1R | A | A | A | A | A | A | not held | not held | not held | 0 / 1 | 0–1 | 0% |
| Zurich Open | Q3 | W | A | A | A | A | A | A | A | A | A | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | 1 / 1 | 4–0 | 100% |
| Kremlin Cup | A | QF | A | A | A | A | A | A | A | A | A | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | not held / not Tier I | 0 / 1 | 1–0 | 100% |
| Win–loss | 2–1 | 10–3 | 4–1 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 4–0 | 0–0 | 0–0 | 0–1 | 0–0 | 0–0 | 0–1 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 0–0 | 2 / 11 | 20–7 | 74% |
| Career statistics ||||||||||||||||||||||||||||||
| Tournament | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | Career total | Career total | Career total |
| Tournaments | 3 | 9 | 8 | 3 | 4 | 3 | 2 | 0 | 0 | 0 | 1 | 5 | 6 | 4 | 0 | 3 | 4 | 3 | 0 | 4 | 0 | 1 | 0 | 1 | 0 | 2 | 66 | 66 | 66 |
| Titles | 0 | 2 | 3 | 2 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 23 | 23 | 23 |
| Finals | 0 | 2 | 4 | 2 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 25 | 25 | 25 |
| Overall win–loss | 4–2 | 16–5 | 29–4 | 15–0 | 10–2 | 11–1 | 9–1 | 0–0 | 0–0 | 0–0 | 1–0 | 16–2 | 24–2 | 18–1 | 0–0 | 13–1 | 7–3 | 4–3 | 0–1 | 8–3 | 0–0 | 2–2 | 0–0 | 3–1 | 0–0 | 2–1 | 192–35 | 192–35 | 192–35 |
| Year-end ranking | 121 | 36 | 10 | 54 | 54 | 25 | – | – | – | – | – | 28 | 3 | 11 | – | 31 | 63 | 133 | – | 31 | – | 292 | – | 397 | 431 | – | 85% | 85% | 85% |

### Mixed doubles

| Tournament | 1998 | 1999 | 2000–2011 | 2012 | 2013–18 | 2019 | 2020 | 2021 | 2022 | SR | W–L | Win% |
| Grand Slam tournaments |||||||||||||
| Australian Open | 1R | F | A | A | A | A | A | A | A | 0 / 2 | 4–2 | 67% |
| French Open | F | A | A | 1R | A | A | NH | A | A | 0 / 2 | 5–2 | 71% |
| Wimbledon | W | A | A | A | A | 3R | NH | A | A | 1 / 2 | 8–1 | 89% |
| US Open | W | A | A | A | A | A | NH | A | A | 1 / 1 | 4–0 | 100% |
| Win–loss | 15–2 | 4–1 | 0–0 | 0–1 | 0–0 | 2–1 | 0–0 | 0–0 | 0–0 | 2 / 7 | 21–5 | 81% |
* 1 2 Boycott of BNP Paribas Open by Venus and Serena Williams
* ↑ Serena ended as ranked number 321 upon retirement from the sport.

## Grand Slam tournament finals
### Singles: 33 (23 titles, 10 runner-ups)

Williams has won an Open Era record 23 Grand Slam singles titles. To win those titles, she has beaten 12 different players who have been ranked No. 1, including her sister, Venus Williams, seven times. She is also one of only two players in the Open Era to have won each major three or more times.
| Result | Year | Tournament | Surface | Opponent | Score |
| Win | 1999 | US Open | Hard | Martina Hingis | 6–3, 7–6$^{(7–4)}$ |
| Loss | 2001 | US Open | Hard | Venus Williams | 2–6, 4–6 |
| Win | 2002 | French Open | Clay | Venus Williams | 7–5, 6–3 |
| Win | 2002 | Wimbledon | Grass | Venus Williams | 7–6$^{(7–4)}$, 6–3 |
| Win | 2002 | US Open (2) | Hard | Venus Williams | 6–4, 6–3 |
| Win | 2003 | Australian Open | Hard | Venus Williams | 7–6$^{(7–4)}$, 3–6, 6–4 |
| Win | 2003 | Wimbledon (2) | Grass | Venus Williams | 4–6, 6–4, 6–2 |
| Loss | 2004 | Wimbledon | Grass | Maria Sharapova | 1–6, 4–6 |
| Win | 2005 | Australian Open (2) | Hard | Lindsay Davenport | 2–6, 6–3, 6–0 |
| Win | 2007 | Australian Open (3) | Hard | Maria Sharapova | 6–1, 6–2 |
| Loss | 2008 | Wimbledon | Grass | Venus Williams | 5–7, 4–6 |
| Win | 2008 | US Open (3) | Hard | Jelena Janković | 6–4, 7–5 |
| Win | 2009 | Australian Open (4) | Hard | Dinara Safina | 6–0, 6–3 |
| Win | 2009 | Wimbledon (3) | Grass | Venus Williams | 7–6$^{(7–3)}$, 6–2 |
| Win | 2010 | Australian Open (5) | Hard | Justine Henin | 6–4, 3–6, 6–2 |
| Win | 2010 | Wimbledon (4) | Grass | Vera Zvonareva | 6–3, 6–2 |
| Loss | 2011 | US Open | Hard | Samantha Stosur | 2–6, 3–6 |
| Win | 2012 | Wimbledon (5) | Grass | Agnieszka Radwańska | 6–1, 5–7, 6–2 |
| Win | 2012 | US Open (4) | Hard | Victoria Azarenka | 6–2, 2–6, 7–5 |
| Win | 2013 | French Open (2) | Clay | Maria Sharapova | 6–4, 6–4 |
| Win | 2013 | US Open (5) | Hard | Victoria Azarenka | 7–5, 6–7$^{(6–8)}$, 6–1 |
| Win | 2014 | US Open (6) | Hard | Caroline Wozniacki | 6–3, 6–3 |
| Win | 2015 | Australian Open (6) | Hard | Maria Sharapova | 6–3, 7–6$^{(7–5)}$ |
| Win | 2015 | French Open (3) | Clay | Lucie Šafářová | 6–3, 6–7$^{(2–7)}$, 6–2 |
| Win | 2015 | Wimbledon (6) | Grass | Garbiñe Muguruza | 6–4, 6–4 |
| Loss | 2016 | Australian Open | Hard | Angelique Kerber | 4–6, 6–3, 4–6 |
| Loss | 2016 | French Open | Clay | Garbiñe Muguruza | 5–7, 4–6 |
| Win | 2016 | Wimbledon (7) | Grass | Angelique Kerber | 7–5, 6–3 |
| Win | 2017 | Australian Open (7) | Hard | Venus Williams | 6–4, 6–4 |
| Loss | 2018 | Wimbledon | Grass | Angelique Kerber | 3–6, 3–6 |
| Loss | 2018 | US Open | Hard | Naomi Osaka | 2–6, 4–6 |
| Loss | 2019 | Wimbledon | Grass | Simona Halep | 2–6, 2–6 |
| Loss | 2019 | US Open | Hard | Bianca Andreescu | 3–6, 5–7 |

### Women's doubles: 14 (14 titles)

Serena and Venus are the only doubles team to win their first 14 Grand Slam doubles finals and have never lost a Grand Slam doubles final.
| Result | Year | Tournament | Surface | Partner | Opponents | Score |
| Win | 1999 | French Open | Clay | Venus Williams | Martina Hingis Anna Kournikova | 6–3, 6–7$^{(2–7)}$, 8–6 |
| Win | 1999 | US Open | Hard | Venus Williams | Chanda Rubin Sandrine Testud | 4–6, 6–1, 6–4 |
| Win | 2000 | Wimbledon | Grass | Venus Williams | Julie Halard-Decugis Ai Sugiyama | 6–3, 6–2 |
| Win | 2001 | Australian Open | Hard | Venus Williams | Lindsay Davenport Corina Morariu | 6–2, 4–6, 6–4 |
| Win | 2002 | Wimbledon (2) | Grass | Venus Williams | Virginia Ruano Pascual Paola Suárez | 6–2, 7–5 |
| Win | 2003 | Australian Open (2) | Hard | Venus Williams | Virginia Ruano Pascual Paola Suárez | 4–6, 6–4, 6–3 |
| Win | 2008 | Wimbledon (3) | Grass | Venus Williams | Lisa Raymond Samantha Stosur | 6–2, 6–2 |
| Win | 2009 | Australian Open (3) | Hard | Venus Williams | Daniela Hantuchová Ai Sugiyama | 6–3, 6–3 |
| Win | 2009 | Wimbledon (4) | Grass | Venus Williams | Samantha Stosur Rennae Stubbs | 7–6$^{(7–4)}$, 6–4 |
| Win | 2009 | US Open (2) | Hard | Venus Williams | Cara Black Liezel Huber | 6–2, 6–2 |
| Win | 2010 | Australian Open (4) | Hard | Venus Williams | Cara Black Liezel Huber | 6–4, 6–3 |
| Win | 2010 | French Open (2) | Clay | Venus Williams | Květa Peschke Katarina Srebotnik | 6–2, 6–3 |
| Win | 2012 | Wimbledon (5) | Grass | Venus Williams | Andrea Hlaváčková Lucie Hradecká | 7–5, 6–4 |
| Win | 2016 | Wimbledon (6) | Grass | Venus Williams | Tímea Babos Yaroslava Shvedova | 6–3, 6–4 |

### Mixed doubles: 4 (2 titles, 2 runner-ups)

| Result | Year | Tournament | Surface | Partner | Opponents | Score |
| Loss | 1998 | French Open | Clay | Luis Lobo | Justin Gimelstob Venus Williams | 3–6, 4–6 |
| Win | 1998 | Wimbledon | Grass | Max Mirnyi | Mahesh Bhupathi Mirjana Lučić | 6–4, 6–4 |
| Win | 1998 | US Open | Hard | Max Mirnyi | Patrick Galbraith Lisa Raymond | 6–2, 6–2 |
| Loss | 1999 | Australian Open | Hard | Max Mirnyi | David Adams Mariaan de Swardt | 4–6, 6–4, 6–7$^{(5–7)}$ |

## Other significant finals
### Olympic finals
#### Singles: 1 (1 gold medal)

| Result | Year | Tournament | Surface | Opponent | Score |
| Gold | 2012 | London Olympics | Grass | Maria Sharapova | 6–0, 6–1 |

#### Doubles: 3 (3 gold medals)

| Result | Year | Tournament | Surface | Partner | Opponents | Score |
| Gold | 2000 | Sydney Olympics | Hard | Venus Williams | Kristie Boogert Miriam Oremans | 6–1, 6–1 |
| Gold | 2008 | Beijing Olympics (2) | Hard | Venus Williams | Anabel Medina Garrigues Virginia Ruano Pascual | 6–2, 6–0 |
| Gold | 2012 | London Olympics (3) | Grass | Venus Williams | Andrea Hlaváčková Lucie Hradecká | 6–4, 6–4 |

### Year-end championships finals
#### Singles: 7 (5 titles, 2 runner-ups)

| Result | Year | Tournament | Surface | Opponent | Score |
| Win | 2001 | WTA Finals, Munich | Carpet (i) | Lindsay Davenport | w/o |
| Loss | 2002 | WTA Finals, Los Angeles | Hard (i) | Kim Clijsters | 5–7, 3–6 |
| Loss | 2004 | WTA Finals, Los Angeles | Hard (i) | Maria Sharapova | 6–4, 2–6, 4–6 |
| Win | 2009 | WTA Finals, Doha (2) | Hard | Venus Williams | 6–2, 7–6$^{(7–4)}$ |
| Win | 2012 | WTA Finals, Istanbul (3) | Hard (i) | Maria Sharapova | 6–4, 6–3 |
| Win | 2013 | WTA Finals, Istanbul (4) | Hard (i) | Li Na | 2–6, 6–3, 6–0 |
| Win | 2014 | WTA Finals, Singapore (5) | Hard (i) | Simona Halep | 6–3, 6–0 |

### Tier I / Premier Mandatory & Premier 5 finals
#### Singles: 33 finals (23 titles, 10 runner-ups)

| Result | Year | Tournament | Surface | Opponent | Score |
| Win | 1999 | Indian Wells Open | Hard | Steffi Graf | 6–3, 3–6, 7–5 |
| Loss | 1999 | Miami Open | Hard | Venus Williams | 1–6, 6–4, 4–6 |
| Loss | 2000 | Canadian Open | Hard | Martina Hingis | 6–0, 3–6, 0–3 ret. |
| Win | 2001 | Indian Wells Open (2) | Hard | Kim Clijsters | 4–6, 6–4, 6–2 |
| Win | 2001 | Canadian Open | Hard | Jennifer Capriati | 6–1, 6–7$^{(7–9)}$, 6–3 |
| Win | 2002 | Miami Open | Hard | Jennifer Capriati | 7–5, 7–6$^{(7–4)}$ |
| Loss | 2002 | German Open | Clay | Justine Henin | 2–6, 6–1, 6–7$^{(5–7)}$ |
| Win | 2002 | Italian Open | Clay | Justine Henin | 7–6$^{(8–6)}$, 6–4 |
| Win | 2003 | Miami Open (2) | Hard | Jennifer Capriati | 4–6, 6–4, 6–1 |
| Loss | 2003 | Charleston Open | Clay | Justine Henin | 3–6, 4–6 |
| Win | 2004 | Miami Open (3) | Hard | Elena Dementieva | 6–1, 6–1 |
| Win | 2007 | Miami Open (4) | Hard | Justine Henin | 0–6, 7–5, 6–3 |
| Loss | 2007 | Kremlin Cup | Hard (i) | Elena Dementieva | 7–5, 1–6, 1–6 |
| Win | 2008 | Miami Open (5) | Hard | Jelena Janković | 6–1, 5–7, 6–3 |
| Win | 2008 | Charleston Open | Clay | Vera Zvonareva | 6–4, 3–6, 6–3 |
| Loss | 2009 | Miami Open (2) | Hard | Victoria Azarenka | 3–6, 1–6 |
| Win | 2011 | Canadian Open (2) | Hard | Samantha Stosur | 6–4, 6–2 |
| Win | 2012 | Madrid Open | Clay | Victoria Azarenka | 6–1, 6–3 |
| Loss | 2013 | Qatar Open | Hard | Victoria Azarenka | 6–7$^{(6–8)}$, 6–2, 3–6 |
| Win | 2013 | Miami Open (6) | Hard | Maria Sharapova | 4–6, 6–3, 6–0 |
| Win | 2013 | Madrid Open (2) | Clay | Maria Sharapova | 6–1, 6–4 |
| Win | 2013 | Italian Open (2) | Clay | Victoria Azarenka | 6–1, 6–3 |
| Win | 2013 | Canadian Open (3) | Hard | Sorana Cîrstea | 6–2, 6–0 |
| Loss | 2013 | Cincinnati Open | Hard | Victoria Azarenka | 6–2, 2–6, 6–7$^{(6–8)}$ |
| Win | 2013 | China Open | Hard | Jelena Janković | 6–2, 6–2 |
| Win | 2014 | Miami Open (7) | Hard | Li Na | 7–5, 6–1 |
| Win | 2014 | Italian Open (3) | Clay | Sara Errani | 6–3, 6–0 |
| Win | 2014 | Cincinnati Open | Hard | Ana Ivanovic | 6–4, 6–1 |
| Win | 2015 | Miami Open (8) | Hard | Carla Suárez Navarro | 6–2, 6–0 |
| Win | 2015 | Cincinnati Open (2) | Hard | Simona Halep | 6–3, 7–6$^{(7–5)}$ |
| Loss | 2016 | Indian Wells Open | Hard | Victoria Azarenka | 4–6, 4–6 |
| Win | 2016 | Italian Open (4) | Clay | Madison Keys | 7–6$^{(7–5)}$, 6–3 |
| Loss | 2019 | Canadian Open | Hard | Bianca Andreescu | 1–3 ret. |

#### Doubles: 2 finals (2 titles)

| Result | Year | Tournament | Surface | Partner | Opponents | Score |
| Win | 1998 | Zurich Open | Carpet (i) | Venus Williams | Mariaan de Swardt Elena Tatarkova | 5–7, 6–1, 6–3 |
| Win | 2010 | Madrid Open | Clay | Venus Williams | Gisela Dulko Flavia Pennetta | 6–2, 7–5 |

## WTA career finals
### Singles: 98 (73 titles, 25 runner-ups)

* Legend (pre/post 2009, pre/post 2021)
* Grand Slam tournaments (23–10)
* WTA Tour Finals (5–2)
* Olympic Games (1–0)
* Grand Slam Cup (1–0)
* Tier I / Premier Mandatory & Premier 5 / WTA 1000 (23–10)
* Tier II / Premier / WTA 500 (18–3)
* Tier III, IV & V / International / WTA 250 (2–0)
* Finals by surface
* Hard (47–17)
* Grass (8–4)
* Clay (13–3)
* Carpet (5–1)
* Finals by setting
* Outdoor (64–21)
* Indoor (9–4)
| Result | W–L | Date | Tournament | Tier | Surface | Opponent | Score |
| Win | 1–0 | Feb 1999 | Open GDF Suez, France | Tier II | Carpet (i) | Amélie Mauresmo | 6–2, 3–6, 7–6$^{(7–4)}$ |
| Win | 2–0 | Mar 1999 | Indian Wells Open, United States | Tier I | Hard | Steffi Graf | 6–3, 3–6, 7–5 |
| Loss | 2–1 | Mar 1999 | Miami Open, United States | Tier I | Hard | Venus Williams | 1–6, 6–4, 4–6 |
| Win | 3–1 | Aug 1999 | LA Championships, United States | Tier II | Hard | Julie Halard-Decugis | 6–1, 6–4 |
| Win | 4–1 | Sep 1999 | US Open, United States | Grand Slam | Hard | Martina Hingis | 6–3, 7–6$^{(7–4)}$ |
| Win | 5–1 | Oct 1999 | Grand Slam Cup, Germany | GS Cup | Hard (i) | Venus Williams | 6–1, 3–6, 6–3 |
| Loss | 5–2 | Feb 2000 | Open GDF Suez, France | Tier II | Carpet (i) | Nathalie Tauziat | 5–7, 2–6 |
| Win | 6–2 | Feb 2000 | Faber Grand Prix, Germany | Tier II | Carpet (i) | Denisa Chládková | 6–1, 6–1 |
| Win | 7–2 | Aug 2000 | LA Championships, United States (2) | Tier II | Hard | Lindsay Davenport | 4–6, 6–4, 7–6$^{(7–1)}$ |
| Loss | 7–3 | Aug 2000 | Canadian Open, Canada | Tier I | Hard | Martina Hingis | 6–0, 3–6, 0–3 ret. |
| Win | 8–3 | Oct 2000 | Toyota Princess Cup, Japan | Tier II | Hard | Julie Halard-Decugis | 7–5, 6–1 |
| Win | 9–3 | Mar 2001 | Indian Wells Open, United States (2) | Tier I | Hard | Kim Clijsters | 4–6, 6–4, 6–2 |
| Win | 10–3 | Aug 2001 | Canadian Open, Canada | Tier I | Hard | Jennifer Capriati | 6–1, 6–7$^{(7–9)}$, 6–3 |
| Loss | 10–4 | Sep 2001 | US Open, United States | Grand Slam | Hard | Venus Williams | 2–6, 4–6 |
| Win | 11–4 | Nov 2001 | WTA Finals, Germany | Tour Finals | Carpet (i) | Lindsay Davenport | Walkover |
| Win | 12–4 | Mar 2002 | State Farm Classic, United States | Tier II | Hard | Jennifer Capriati | 6–2, 4–6, 6–4 |
| Win | 13–4 | Apr 2002 | Miami Open, United States | Tier I | Hard | Jennifer Capriati | 7–5, 7–6$^{(7–4)}$ |
| Loss | 13–5 | May 2002 | German Open, Germany | Tier I | Clay | Justine Henin | 2–6, 6–1, 6–7$^{(5–7)}$ |
| Win | 14–5 | May 2002 | Italian Open, Italy | Tier I | Clay | Justine Henin | 7–6$^{(8–6)}$, 6–4 |
| Win | 15–5 | Jun 2002 | French Open, France | Grand Slam | Clay | Venus Williams | 7–5, 6–3 |
| Win | 16–5 | Jul 2002 | Wimbledon, United Kingdom | Grand Slam | Grass | Venus Williams | 7–6$^{(7–4)}$, 6–3 |
| Win | 17–5 | Sep 2002 | US Open, United States (2) | Grand Slam | Hard | Venus Williams | 6–4, 6–3 |
| Win | 18–5 | Sep 2002 | Toyota Princess Cup, Japan (2) | Tier II | Hard | Kim Clijsters | 2–6, 6–3, 6–3 |
| Win | 19–5 | Sep 2002 | Sparkassen Cup, Germany | Tier II | Carpet (i) | Anastasia Myskina | 6–3, 6–2 |
| Loss | 19–6 | Nov 2002 | WTA Finals, United States | Tour Finals | Hard (i) | Kim Clijsters | 5–7, 3–6 |
| Win | 20–6 | Jan 2003 | Australian Open, Australia | Grand Slam | Hard | Venus Williams | 7–6$^{(7–4)}$, 3–6, 6–4 |
| Win | 21–6 | Feb 2003 | Open GDF Suez, France (2) | Tier II | Hard (i) | Amélie Mauresmo | 6–3, 6–2 |
| Win | 22–6 | Mar 2003 | Miami Open, United States (2) | Tier I | Hard | Jennifer Capriati | 4–6, 6–4, 6–1 |
| Loss | 22–7 | Apr 2003 | Charleston Open, United States | Tier I | Clay (green) | Justine Henin | 3–6, 4–6 |
| Win | 23–7 | Jul 2003 | Wimbledon, United Kingdom (2) | Grand Slam | Grass | Venus Williams | 4–6, 6–4, 6–2 |
| Win | 24–7 | Apr 2004 | Miami Open, United States (3) | Tier I | Hard | Elena Dementieva | 6–1, 6–1 |
| Loss | 24–8 | Jun 2004 | Wimbledon, United Kingdom | Grand Slam | Grass | Maria Sharapova | 1–6, 4–6 |
| Loss | 24–9 | Jul 2004 | LA Championships, United States | Tier II | Hard | Lindsay Davenport | 1–6, 3–6 |
| Win | 25–9 | Sep 2004 | China Open, China | Tier II | Hard | Svetlana Kuznetsova | 4–6, 7–5, 6–4 |
| Loss | 25–10 | Nov 2004 | WTA Finals, United States | Tour Finals | Hard (i) | Maria Sharapova | 6–4, 2–6, 4–6 |
| Win | 26–10 | Jan 2005 | Australian Open, Australia (2) | Grand Slam | Hard | Lindsay Davenport | 2–6, 6–3, 6–0 |
| Win | 27–10 | Jan 2007 | Australian Open, Australia (3) | Grand Slam | Hard | Maria Sharapova | 6–1, 6–2 |
| Win | 28–10 | Mar 2007 | Miami Open, United States (4) | Tier I | Hard | Justine Henin | 0–6, 7–5, 6–3 |
| Loss | 28–11 | Oct 2007 | Kremlin Cup, Russia | Tier I | Hard (i) | Elena Dementieva | 7–5, 1–6, 1–6 |
| Win | 29–11 | Mar 2008 | Bangalore Open, India | Tier II | Hard | Patty Schnyder | 7–5, 6–3 |
| Win | 30–11 | Apr 2008 | Miami Open, United States (5) | Tier I | Hard | Jelena Janković | 6–1, 5–7, 6–3 |
| Win | 31–11 | Apr 2008 | Charleston Open, United States | Tier I | Clay (green) | Vera Zvonareva | 6–4, 3–6, 6–3 |
| Loss | 31–12 | Jul 2008 | Wimbledon, United Kingdom | Grand Slam | Grass | Venus Williams | 5–7, 4–6 |
| Win | 32–12 | Sep 2008 | US Open, United States (3) | Grand Slam | Hard | Jelena Janković | 6–4, 7–5 |
| Win | 33–12 | Jan 2009 | Australian Open, Australia (4) | Grand Slam | Hard | Dinara Safina | 6–0, 6–3 |
| Loss | 33–13 | Apr 2009 | Miami Open, United States | Premier M | Hard | Victoria Azarenka | 3–6, 1–6 |
| Win | 34–13 | Jul 2009 | Wimbledon, United Kingdom (3) | Grand Slam | Grass | Venus Williams | 7–6$^{(7–3)}$, 6–2 |
| Win | 35–13 | Nov 2009 | WTA Finals, Qatar (2) | Tour Finals | Hard | Venus Williams | 6–2, 7–6$^{(7–4)}$ |
| Loss | 35–14 | Jan 2010 | Sydney International, Australia | Premier | Hard | Elena Dementieva | 3–6, 2–6 |
| Win | 36–14 | Jan 2010 | Australian Open, Australia (5) | Grand Slam | Hard | Justine Henin | 6–4, 3–6, 6–2 |
| Win | 37–14 | Jul 2010 | Wimbledon, United Kingdom (4) | Grand Slam | Grass | Vera Zvonareva | 6–3, 6–2 |
| Win | 38–14 | Jul 2011 | Stanford Classic, United States | Premier | Hard | Marion Bartoli | 7–5, 6–1 |
| Win | 39–14 | Aug 2011 | Canadian Open, Canada (2) | Premier 5 | Hard | Samantha Stosur | 6–4, 6–2 |
| Loss | 39–15 | Sep 2011 | US Open, United States | Grand Slam | Hard | Samantha Stosur | 2–6, 3–6 |
| Win | 40–15 | Apr 2012 | Charleston Open, United States (2) | Premier | Clay (green) | Lucie Šafářová | 6–0, 6–1 |
| Win | 41–15 | May 2012 | Madrid Open, Spain | Premier M | Clay (blue) | Victoria Azarenka | 6–1, 6–3 |
| Win | 42–15 | Jul 2012 | Wimbledon, United Kingdom (5) | Grand Slam | Grass | Agnieszka Radwańska | 6–1, 5–7, 6–2 |
| Win | 43–15 | Jul 2012 | Stanford Classic, United States (2) | Premier | Hard | CoCo Vandeweghe | 7–5, 6–3 |
| Win | 44–15 | Aug 2012 | Summer Olympics, United Kingdom | Olympics | Grass | Maria Sharapova | 6–0, 6–1 |
| Win | 45–15 | Sep 2012 | US Open, United States (4) | Grand Slam | Hard | Victoria Azarenka | 6–2, 2–6, 7–5 |
| Win | 46–15 | Oct 2012 | WTA Finals, Turkey (3) | Tour Finals | Hard (i) | Maria Sharapova | 6–4, 6–3 |
| Win | 47–15 | Jan 2013 | Brisbane International, Australia | Premier | Hard | Anastasia Pavlyuchenkova | 6–2, 6–1 |
| Loss | 47–16 | Feb 2013 | Qatar Open, Qatar | Premier 5 | Hard | Victoria Azarenka | 6–7$^{(6–8)}$, 6–2, 3–6 |
| Win | 48–16 | Mar 2013 | Miami Open, United States (6) | Premier M | Hard | Maria Sharapova | 4–6, 6–3, 6–0 |
| Win | 49–16 | Apr 2013 | Charleston Open, United States (3) | Premier | Clay (green) | Jelena Janković | 3–6, 6–0, 6–2 |
| Win | 50–16 | May 2013 | Madrid Open, Spain (2) | Premier M | Clay | Maria Sharapova | 6–1, 6–4 |
| Win | 51–16 | May 2013 | Italian Open, Italy (2) | Premier 5 | Clay | Victoria Azarenka | 6–1, 6–3 |
| Win | 52–16 | Jun 2013 | French Open, France (2) | Grand Slam | Clay | Maria Sharapova | 6–4, 6–4 |
| Win | 53–16 | Jul 2013 | Swedish Open, Sweden | International | Clay | Johanna Larsson | 6–4, 6–1 |
| Win | 54–16 | Aug 2013 | Canadian Open, Canada (3) | Premier 5 | Hard | Sorana Cîrstea | 6–2, 6–0 |
| Loss | 54–17 | Aug 2013 | Cincinnati Open, United States | Premier 5 | Hard | Victoria Azarenka | 6–2, 2–6, 6–7$^{(6–8)}$ |
| Win | 55–17 | Sep 2013 | US Open, United States (5) | Grand Slam | Hard | Victoria Azarenka | 7–5, 6–7$^{(6–8)}$, 6–1 |
| Win | 56–17 | Oct 2013 | China Open, China (2) | Premier M | Hard | Jelena Janković | 6–2, 6–2 |
| Win | 57–17 | Oct 2013 | WTA Finals, Turkey (4) | Tour Finals | Hard (i) | Li Na | 2–6, 6–3, 6–0 |
| Win | 58–17 | Jan 2014 | Brisbane International, Australia (2) | Premier | Hard | Victoria Azarenka | 6–4, 7–5 |
| Win | 59–17 | Mar 2014 | Miami Open, United States (7) | Premier M | Hard | Li Na | 7–5, 6–1 |
| Win | 60–17 | May 2014 | Italian Open, Italy (3) | Premier 5 | Clay | Sara Errani | 6–3, 6–0 |
| Win | 61–17 | Aug 2014 | Stanford Classic, United States (3) | Premier | Hard | Angelique Kerber | 7–6$^{(7–1)}$, 6–3 |
| Win | 62–17 | Aug 2014 | Cincinnati Open, United States | Premier 5 | Hard | Ana Ivanovic | 6–4, 6–1 |
| Win | 63–17 | Sep 2014 | US Open, United States (6) | Grand Slam | Hard | Caroline Wozniacki | 6–3, 6–3 |
| Win | 64–17 | Oct 2014 | WTA Finals, Singapore (5) | Tour Finals | Hard (i) | Simona Halep | 6–3, 6–0 |
| Win | 65–17 | Jan 2015 | Australian Open, Australia (6) | Grand Slam | Hard | Maria Sharapova | 6–3, 7–6$^{(7–5)}$ |
| Win | 66–17 | Apr 2015 | Miami Open, United States (8) | Premier M | Hard | Carla Suárez Navarro | 6–2, 6–0 |
| Win | 67–17 | Jun 2015 | French Open, France (3) | Grand Slam | Clay | Lucie Šafářová | 6–3, 6–7$^{(2–7)}$, 6–2 |
| Win | 68–17 | Jul 2015 | Wimbledon, United Kingdom (6) | Grand Slam | Grass | Garbiñe Muguruza | 6–4, 6–4 |
| Win | 69–17 | Aug 2015 | Cincinnati Open, United States (2) | Premier 5 | Hard | Simona Halep | 6–3, 7–6$^{(7–5)}$ |
| Loss | 69–18 | Jan 2016 | Australian Open, Australia | Grand Slam | Hard | Angelique Kerber | 4–6, 6–3, 4–6 |
| Loss | 69–19 | Mar 2016 | Indian Wells Open, United States | Premier M | Hard | Victoria Azarenka | 4–6, 4–6 |
| Win | 70–19 | May 2016 | Italian Open, Italy (4) | Premier 5 | Clay | Madison Keys | 7–6$^{(7–5)}$, 6–3 |
| Loss | 70–20 | Jun 2016 | French Open, France | Grand Slam | Clay | Garbiñe Muguruza | 5–7, 4–6 |
| Win | 71–20 | Jul 2016 | Wimbledon, United Kingdom (7) | Grand Slam | Grass | Angelique Kerber | 7–5, 6–3 |
| Win | 72–20 | Jan 2017 | Australian Open, Australia (7) | Grand Slam | Hard | Venus Williams | 6–4, 6–4 |
| Loss | 72–21 | Jul 2018 | Wimbledon, United Kingdom | Grand Slam | Grass | Angelique Kerber | 3–6, 3–6 |
| Loss | 72–22 | Sep 2018 | US Open, United States | Grand Slam | Hard | Naomi Osaka | 2–6, 4–6 |
| Loss | 72–23 | Jul 2019 | Wimbledon, United Kingdom | Grand Slam | Grass | Simona Halep | 2–6, 2–6 |
| Loss | 72–24 | Aug 2019 | Canadian Open, Canada | Premier 5 | Hard | Bianca Andreescu | 1–3 ret. |
| Loss | 72–25 | Sep 2019 | US Open, United States | Grand Slam | Hard | Bianca Andreescu | 3–6, 5–7 |
| Win | 73–25 | Jan 2020 | Auckland Open, New Zealand | International | Hard | Jessica Pegula | 6–3, 6–4 |

### Doubles: 25 (23 titles, 2 runner-up)

* Legend (pre/post 2009)
* Grand Slam tournaments (14–0)
* WTA Tour Finals (0–0)
* Olympic Games (3–0)
* Tier I / Premier Mandatory & Premier 5 (2–0)
* Tier II / Premier (3–1)
* Tier III, IV & V / International (1–1)
* Finals by surface
* Hard (10–2)
* Grass (7–0)
* Clay (3–0)
* Carpet (3–0)
* Finals by setting
* Outdoor (19–2)
* Indoor (4–0)
| Result | W–L | Date | Tournament | Tier | Surface | Partner | Opponents | Score |
| Win | 1–0 | Feb 1998 | US National Championships, United States | Tier III | Hard (i) | Venus Williams | Cătălina Cristea Kristine Kunce | 7–5, 6–2 |
| Win | 2–0 | Oct 1998 | Zurich Open, Switzerland | Tier I | Carpet (i) | Venus Williams | Mariaan de Swardt Elena Tatarkova | 5–7, 6–1, 6–3 |
| Win | 3–0 | Feb 1999 | Faber Grand Prix, Germany | Tier II | Carpet (i) | Venus Williams | Alexandra Fusai Nathalie Tauziat | 5–7, 6–2, 6–2 |
| Win | 4–0 | May 1999 | French Open, France | Grand Slam | Clay | Venus Williams | Martina Hingis Anna Kournikova | 6–3, 6–7$^{(2–7)}$, 8–6 |
| Loss | 4–1 | Aug 1999 | Southern California Open, United States | Tier II | Hard | Venus Williams | Lindsay Davenport Corina Morariu | 4–6, 1–6 |
| Win | 5–1 | Aug 1999 | US Open, United States | Grand Slam | Hard | Venus Williams | Chanda Rubin Sandrine Testud | 4–6, 6–1, 6–4 |
| Win | 6–1 | Jun 2000 | Wimbledon, United Kingdom | Grand Slam | Grass | Venus Williams | Julie Halard-Decugis Ai Sugiyama | 6–3, 6–2 |
| Win | 7–1 | Sep 2000 | Summer Olympics, Australia | Olympics | Hard | Venus Williams | Kristie Boogert Miriam Oremans | 6–1, 6–1 |
| Win | 8–1 | Jan 2001 | Australian Open, Australia | Grand Slam | Hard | Venus Williams | Lindsay Davenport Corina Morariu | 6–2, 4–6, 6–4 |
| Win | 9–1 | Jun 2002 | Wimbledon, United Kingdom (2) | Grand Slam | Grass | Venus Williams | Virginia Ruano Pascual Paola Suárez | 6–2, 7–5 |
| Win | 10–1 | Sep 2002 | Sparkassen Cup, Germany | Tier II | Carpet (i) | Alexandra Stevenson | Janette Husárová Paola Suárez | 6–3, 7–5 |
| Win | 11–1 | Jan 2003 | Australian Open, Australia (2) | Grand Slam | Hard | Venus Williams | Virginia Ruano Pascual Paola Suárez | 4–6, 6–4, 6–3 |
| Win | 12–1 | Jul 2008 | Wimbledon, United Kingdom (3) | Grand Slam | Grass | Venus Williams | Lisa Raymond Samantha Stosur | 6–2, 6–2 |
| Win | 13–1 | Aug 2008 | Summer Olympics, China (2) | Olympics | Hard | Venus Williams | Anabel Medina Garrigues Virginia Ruano Pascual | 6–2, 6–0 |
| Win | 14–1 | Jan 2009 | Australian Open, Australia (3) | Grand Slam | Hard | Venus Williams | Ai Sugiyama Daniela Hantuchová | 6–3, 6–3 |
| Win | 15–1 | Jul 2009 | Wimbledon, United Kingdom (4) | Grand Slam | Grass | Venus Williams | Samantha Stosur Rennae Stubbs | 7–6$^{(7–4)}$, 6–4 |
| Win | 16–1 | Aug 2009 | Stanford Classic, United States | Premier | Hard | Venus Williams | Chan Yung-jan Monica Niculescu | 6–4, 6–1 |
| Win | 17–1 | Sep 2009 | US Open, United States (2) | Grand Slam | Hard | Venus Williams | Cara Black Liezel Huber | 6–2, 6–2 |
| Win | 18–1 | Jan 2010 | Australian Open, Australia (4) | Grand Slam | Hard | Venus Williams | Cara Black Liezel Huber | 6–4, 6–3 |
| Win | 19–1 | May 2010 | Madrid Open, Spain | Premier M | Clay | Venus Williams | Gisela Dulko Flavia Pennetta | 6–2, 7–5 |
| Win | 20–1 | Jun 2010 | French Open, France (2) | Grand Slam | Clay | Venus Williams | Květa Peschke Katarina Srebotnik | 6–2, 6–3 |
| Win | 21–1 | Jul 2012 | Wimbledon, United Kingdom (5) | Grand Slam | Grass | Venus Williams | Andrea Hlaváčková Lucie Hradecká | 7–5, 6–4 |
| Win | 22–1 | Aug 2012 | Summer Olympics, United Kingdom (3) | Olympics | Grass | Venus Williams | Andrea Hlaváčková Lucie Hradecká | 6–4, 6–4 |
| Win | 23–1 | Jul 2016 | Wimbledon, United Kingdom (6) | Grand Slam | Grass | Venus Williams | Tímea Babos Yaroslava Shvedova | 6–3, 6–4 |
| Loss | 23–2 | Jan 2020 | Auckland Open, New Zealand | International | Hard | Caroline Wozniacki | Asia Muhammad Taylor Townsend | 4–6, 4–6 |

### Team competition: 4 (3 titles, 1 runner-up)

| Result | Date | Tournament | Surface | Partners | Opponents | Score |
| Win | Sep 1999 | Fed Cup, United States | Hard | Lindsay Davenport Venus Williams Monica Seles | Elena Makarova Elena Likhovtseva Elena Dementieva | 4–1 |
| Win | Jan 2003 | Hopman Cup, Australia | Hard | James Blake | Alicia Molik Lleyton Hewitt | 3–0 |
| Win | Jan 2008 | Hopman Cup, Australia | Hard | Mardy Fish | Jelena Janković Novak Djokovic | 2–1 |
| Loss | Jan 2015 | Hopman Cup, Australia | Hard | John Isner | Agnieszka Radwańska Jerzy Janowicz | 1–2 |

## Fed Cup participation

Current through the 2020 Billie Jean King Cup qualifying round
* Group membership
* World Group (7–1)
* Qualifying round (1–1)
* World Group play-off (6–1)
* World Group II (3–0)
* Matches by surface
* Hard (10–2)
* Clay (7–1)
* Grass (0–0)
* Matches by type
* Singles (14–1)
* Doubles (3–2)
* Matches by location
* United States (10–2)
* Away (7–1)

### Singles (14–1)

| Edition | Round | Date | Location | Opponent nation | Surface | Opponent player | Result | Score | Team result |
| 1999 | WG SF | Jul 1999 | Ancona, Italy | Italy | Clay | Rita Grande | Win | 6–1, 6–1 | Win 4–1 |
| 2003 | WG 1R | Apr 2003 | Lowell, United States | Czech Republic | Hard (i) | Iveta Benešová | Win | 7–5, 6–1 | Win 5–0 |
| 2003 | WG 1R | Apr 2003 | Lowell, United States | Czech Republic | Hard (i) | Klára Koukalová | Win | 6–2, 6–2 | Win 5–0 |
| 2007 | WG 1R | Apr 2007 | Delray Beach, United States | Belgium | Hard | Caroline Maes | Win | 6–1, 6–4 | Win 5–0 |
| 2012 | WG II | Feb 2012 | Worcester, United States | Belarus | Hard (i) | Olga Govortsova | Win | 7–5, 6–0 | Win 5–0 |
| 2012 | WG II | Feb 2012 | Worcester, United States | Belarus | Hard (i) | Anastasiya Yakimova | Win | 5–7, 6–1, 6–1 | Win 5–0 |
| 2012 | WG PO | Apr 2012 | Kharkiv, Ukraine | Ukraine | Clay | Elina Svitolina | Win | 6–2, 6–1 | Win 5–0 |
| 2012 | WG PO | Apr 2012 | Kharkiv, Ukraine | Ukraine | Clay | Lesia Tsurenko | Win | 6–3, 6–2 | Win 5–0 |
| 2013 | WG PO | Apr 2013 | Delray Beach, United States | Sweden | Hard | Johanna Larsson | Win | 6–2, 6–2 | Win 3–2 |
| 2013 | WG PO | Apr 2013 | Delray Beach, United States | Sweden | Hard | Sofia Arvidsson | Win | 6–2, 6–1 | Win 3–2 |
| 2015 | WG II | Feb 2015 | Buenos Aires, Argentina | Argentina | Clay | María Irigoyen | Win | 7–5, 6–0 | Win 4–1 |
| 2015 | WG PO | Apr 2015 | Brindisi, Italy | Italy | Clay | Camila Giorgi | Win | 7–6$^{(7–5)}$, 6–2 | Loss 2–3 |
| 2015 | WG PO | Apr 2015 | Brindisi, Italy | Italy | Clay | Sara Errani | Win | 4–6, 7–6$^{(7–5)}$, 6–3 | Loss 2–3 |
| 2020 | QR | Feb 2020 | Everest, United States | Latvia | Hard (i) | Jeļena Ostapenko | Win | 7–6$^{(7–4)}$, 7–6$^{(7–3)}$ | Win 3–2 |
| 2020 | QR | Feb 2020 | Everest, United States | Latvia | Hard (i) | Anastasija Sevastova | Loss | 6–7$^{(5–7)}$, 6–3, 6–7$^{(4–7)}$ | Win 3–2 |

### Doubles (3–2)

| Edition | Round | Date | Location | Opponent nation | Surface | Partner | Opponent players | Result | Score | Team result |
| 1999 | WG SF | Jul 1999 | Ancona, Italy | Italy | Clay | Venus Williams | Tathiana Garbin Adriana Serra Zanetti | Win | 6–2, 6–2 | Win 4–1 |
| 1999 | WG F | Sep 1999 | Stanford, United States | Russia | Hard | Venus Williams | Elena Dementieva Elena Makarova | Win | 6–2, 6–1 | Win 4–1 |
| 2003 | WG 1R | Apr 2003 | Lowell, United States | Czech Republic | Hard (i) | Venus Williams | Dája Bedáňová Eva Birnerová | Win | 6–0, 6–1 | Win 5–0 |
| 2015 | WG PO | Apr 2015 | Brindisi, Italy | Italy | Clay | Alison Riske | Sara Errani Flavia Pennetta | Loss | 0–6, 3–6 | Loss 2–3 |
| 2018 | WG QF | Feb 2018 | Asheville, United States | Netherlands | Hard (i) | Venus Williams | Lesley Kerkhove Demi Schuurs | Loss | 2–6, 3–6 | Win 3–1 |

## Head-to-head records
### Record against top 10 players

Williams's record against players who have been ranked in the top 10. She has recorded wins against 22 of the other 26 women who have been ranked No. 1 in the Open Era, with the other 4 players retiring before her professional career began in 1995.
Active players are in boldface.
| Player | Years | Record | Win % | Hard | Clay | Grass | Carpet | Last match |
| Number 1 ranked players | | | | | | | | |
| Ashleigh Barty | 2014–2018 | 2–0 | 100% | 1–0 | 1–0 | – | – | Won (3–6, 6–3, 6–4) at 2018 French Open |
| Aryna Sabalenka | 2021 | 1–0 | 100% | 1–0 | – | – | – | Won (6–4, 2–6, 6–4) at 2021 Australian Open |
| Maria Sharapova | 2004–2019 | 20–2 | 91% | 13–1 | 4–0 | 3–1 | – | Won (6–1, 6–1) at 2019 US Open |
| Caroline Wozniacki | 2009–2014 | 10–1 | 91% | 8–1 | 1–0 | 1–0 | – | Won (2–6, 6–3, 7–6$^{(8–6)}$) at 2014 WTA Finals |
| / Ana Ivanovic | 2006–2015 | 9–1 | 90% | 8–1 | 1–0 | – | – | Won (3–6, 6–4, 6–2) at 2015 Cincinnati |
| Dinara Safina | 2002–2009 | 6–1 | 86% | 5–0 | 1–1 | – | – | Won (6–0, 6–3) at 2009 Australian Open |
| Simona Halep | 2011–2021 | 10–2 | 83% | 8–1 | 1–0 | 1–1 | – | Won (6–3, 6–3) at 2021 Australian Open |
| Amélie Mauresmo | 1999–2008 | 10–2 | 83% | 6–1 | 1–1 | 3–0 | – | Won (7–6$^{(7–5)}$, 6–1) at 2008 Wimbledon |
| / Monica Seles | 1997–2001 | 4–1 | 80% | 3–1 | – | – | 1–0 | Won (7–5, 7–6$^{(7–5)}$) at 2001 Toronto |
| Victoria Azarenka | 2008–2020 | 18–5 | 78% | 10–5 | 4–0 | 4–0 | – | Lost (6–1, 3–6, 3–6) at 2020 US Open |
| Kim Clijsters | 1999–2009 | 7–2 | 78% | 7–2 | – | – | – | Lost (4–6, 5–7) at 2009 US Open |
| Lindsay Davenport | 1997–2005 | 10–4 | 71% | 8–3 | 1–0 | – | 1–1 | Won (2–6, 6–3, 6–0) at 2005 Australian Open |
| / Jelena Janković | 2004–2014 | 10–4 | 71% | 8–3 | 1–1 | 1–0 | – | Won (6–1, 6–3) at 2014 Cincinnati |
| Angelique Kerber | 2007–2018 | 6–3 | 67% | 5–2 | – | 1–1 | – | Lost (3–6, 3–6) at 2018 Wimbledon |
| Venus Williams | 1998–2020 | 19–12 | 61% | 12–9 | 2–1 | 4–2 | 1–0 | Won (3–6, 6–3, 6–4) at 2020 Lexington |
| Jennifer Capriati | 1999–2004 | 10–7 | 59% | 5–3 | 3–3 | 2–1 | – | Lost (6–2, 4–6, 4–6) at 2004 US Open |
| Justine Henin | 2001–2010 | 8–6 | 57% | 5–1 | 1–4 | 1–1 | 1–0 | Won (6–4, 3–6, 6–2) at 2010 Australian Open |
| Martina Hingis | 1998–2002 | 7–6 | 54% | 7–5 | 0–1 | – | – | Won (6–4, 6–0) at 2002 Miami |
| Garbiñe Muguruza | 2013–2019 | 3–3 | 50% | 2–1 | 0–2 | 1–0 | – | Lost (3–6, 0–1 ret.) at 2019 Indian Wells |
| Karolína Plíšková | 2014–2019 | 2–2 | 50% | 2–2 | – | – | – | Lost (4–6, 6–4, 5–7) at 2019 Australian Open |
| Steffi Graf | 1999 | 1–1 | 50% | 1–1 | – | – | – | Won (6–3, 3–6, 7–5) at 1999 Indian Wells |
| Arantxa Sánchez Vicario | 1998–2000 | 3–4 | 43% | 2–1 | 0–2 | 0–1 | 1–0 | Won (6–2, 6–4) at 2000 Montreal |
| Naomi Osaka | 2018–2021 | 1–3 | 25% | 1–3 | – | – | – | Lost (3–6, 4–6) at 2021 Australian Open |
| Number 2 ranked players | | | | | | | | |
| Agnieszka Radwańska | 2008–2016 | 10–0 | 100% | 7–0 | 1–0 | 2–0 | – | Won (6–4, 7–6$^{(7–1)}$) at 2016 Indian Wells |
| Conchita Martínez | 1998–2003 | 5–0 | 100% | 2–0 | 3–0 | – | – | Won (7–5, 6–2) at 2003 Rome |
| Anastasia Myskina | 1997–2006 | 5–0 | 100% | 2–0 | 1–0 | – | 2–0 | Won (6–2, 6–2) at 2006 Cincinnati |
| Anett Kontaveit | 2022 | 1–0 | 100% | 1–0 | – | – | – | Won (7–6$^{(7–4)}$, 2–6, 6–2) at 2022 US Open |
| Jana Novotná | 1998 | 1–0 | 100% | 1–0 | – | – | – | Won (2–6, 6–3, 2–0 ret.) at 1998 Stuttgart |
| Li Na | 2006–2014 | 11–1 | 92% | 10–1 | – | 1–0 | – | Won (7–5, 6–1) at 2014 Miami |
| Vera Zvonareva | 2002–2015 | 8–2 | 80% | 4–1 | 2–0 | 2–1 | – | Won (7–5, 6–0) at 2015 Australian Open |
| Svetlana Kuznetsova | 2004–2016 | 10–3 | 77% | 5–2 | 3–1 | 1–0 | 1–0 | Won (7–5, 6–0) at 2016 Wimbledon |
| Petra Kvitová | 2010–2018 | 5–2 | 71% | 3–1 | 0–1 | 2–0 | – | Lost (3–6, 6–2, 3–6) at 2018 Cincinnati |
| Number 3 ranked players | | | | | | | | |
| Amanda Coetzer | 1999 | 1–0 | 100% | 1–0 | – | – | – | Won (6–4, 6–0) at 1999 Miami |
| Jessica Pegula | 2020 | 1–0 | 100% | 1–0 | – | – | – | Won (6–3, 6–4) at 2020 Auckland |
| Sloane Stephens | 2013–2020 | 6–1 | 86% | 4–1 | 2–0 | – | – | Won (2–6, 6–2, 6–2) at 2020 US Open |
| Mary Pierce | 1997–2005 | 5–1 | 83% | 1–1 | 3–0 | – | 1–0 | Won (7–6$^{(7–5)}$, 6–4) at 2005 Amelia Island |
| Elina Svitolina | 2012–2019 | 5–1 | 83% | 3–1 | 2–0 | – | – | Won (6–3, 6–1) at 2019 US Open |
| Nadia Petrova | 2000–2012 | 7–3 | 70% | 5–1 | 2–2 | – | – | Won (4–6, 6–2, 6–3) at 2012 Rome |
| Nathalie Tauziat | 1998–2000 | 2–1 | 67% | 1–1 | 1–0 | – | – | Lost (5–7, 2–6) at 2000 Paris |
| Elena Dementieva | 2003–2010 | 7–5 | 58% | 5–4 | – | 2–0 | 0–1 | Lost (3–6, 2–6) at 2010 Sydney |
| Maria Sakkari | 2020 | 1–1 | 50% | 1–1 | – | – | – | Won (6–3, 6–7$^{(4–7)}$, 6–3) at 2020 US Open |
| Elena Rybakina | 2021 | 0–1 | 0% | – | 0–1 | – | – | Lost (3–6, 5–7) at 2021 French Open |
| Number 4 ranked players | | | | | | | | |
| Dominika Cibulková | 2010–2015 | 5–0 | 100% | 3–0 | 1–0 | 1–0 | – | Won (6–2, 6–2) at 2015 Australian Open |
| / Jelena Dokić | 2000–2003 | 4–0 | 100% | 2–0 | 1–0 | – | 1–0 | Won (6–2, 6–2) at 2003 Charleston |
| Magdalena Maleeva | 2000–2002 | 4–0 | 100% | 2–0 | 1–0 | 1–0 | – | Won (6–3, 6–3) at 2002 Berlin |
| Kiki Bertens | 2015–2018 | 3–0 | 100% | 2–0 | 1–0 | – | – | Won (7–6$^{(7–5)}$, 7–5) at 2018 Indian Wells |
| Caroline Garcia | 2013–2014 | 3–0 | 100% | 1–0 | 1–0 | 1–0 | – | Won (6–4, 4–6, 6–4) at 2014 Miami |
| Kimiko Date | 2013 | 1–0 | 100% | – | – | 1–0 | – | Won (6–2, 6–0) at 2013 Wimbledon |
| Iva Majoli | 2001 | 1–0 | 100% | 1–0 | – | – | – | Won (7–6$^{(7–2)}$, 6–1) at 2001 Toronto |
| Francesca Schiavone | 2003–2013 | 7–2 | 78% | 5–0 | 1–2 | 1–0 | – | Won (6–4, 7–5) at 2013 Beijing |
| Samantha Stosur | 2008–2014 | 8–3 | 73% | 7–2 | 1–1 | – | – | Won (7–6$^{(9–7)}$, 7–6$^{(9–7)}$) at 2014 Cincinnati |
| Belinda Bencic | 2014–2022 | 2–2 | 50% | 1–2 | 1–0 | – | – | Lost (2–6, 4–6) at 2022 Toronto |
| Johanna Konta | 2017–2018 | 1–1 | 50% | 1–1 | – | – | – | Lost (1–6, 0–6) at 2018 San Jose |
| Mary Joe Fernández | 1999 | 0–1 | 0% | – | 0–1 | – | – | Lost (3–6, 6–1, 0–6) at 1999 French Open |
| Sofia Kenin | 2019 | 0–1 | 0% | – | 0–1 | – | – | Lost (2–6, 5–7) at 2019 French Open |
| Bianca Andreescu | 2019 | 0–2 | 0% | 0–2 | – | – | – | Lost (3–6, 5–7) 2019 US Open |
| Number 5 ranked players | | | | | | | | |
| Lucie Šafářová | 2007–2017 | 10–0 | 100% | 7–0 | 3–0 | – | – | Won (6–3, 6–4) at 2017 Australian Open |
| Sara Errani | 2008–2015 | 9–0 | 100% | 3–0 | 6–0 | – | – | Won (6–1, 6–3) at 2015 French Open |
| Eugenie Bouchard | 2013–2019 | 3–0 | 100% | 3–0 | – | – | – | Won (6–2, 6–2) at 2019 Australian Open |
| Madison Keys | 2015–2016 | 3–0 | 100% | 2–0 | 1–0 | – | – | Won (7–6$^{(7–5)}$, 6–3) at 2016 Rome |
| Jeļena Ostapenko | 2020 | 1–0 | 100% | 1–0 | – | – | – | Won (7–6$^{(7–4)}$, 7–6$^{(7–3)}$) at 2020 Fed Cup |
| Daniela Hantuchová | 2002–2014 | 9–1 | 90% | 6–1 | – | 3–0 | – | Won (6–3, 6–3) at 2014 Australian Open |
| Anna Chakvetadze | 2007–2010 | 1–1 | 50% | 0–1 | – | 1–0 | – | Won (6–0, 6–1) at 2010 Wimbledon |
| Number 6 ranked players | | | | | | | | |
| Flavia Pennetta | 2008–2015 | 7–0 | 100% | 6–0 | 1–0 | – | – | Won (2–6, 6–3, 6–0) at 2015 Toronto |
| Carla Suárez Navarro | 2010–2019 | 7–0 | 100% | 3–0 | 3–0 | 1–0 | – | Won (6–2, 6–2) at 2019 Wimbledon |
| Chanda Rubin | 2002 | 1–1 | 50% | 0–1 | – | 1–0 | – | Lost (2–6, 6–4, 5–7) at 2002 Los Angeles |
| Number 7 ranked players | | | | | | | | |
| Julie Halard-Decugis | 1999–2000 | 4–0 | 100% | 2–0 | – | – | 2–0 | Won (7–5, 6–1) at 2000 Tokyo |
| Nicole Vaidišová | 2007–2008 | 4–0 | 100% | 3–0 | – | – | 1–0 | Won (6–3, 6–4) at 2008 Australian Open |
| Barbara Schett | 2001–2003 | 3–0 | 100% | 1–0 | 2–0 | – | – | Won (6–0, 6–0) at 2003 French Open |
| Danielle Collins | 2021 | 2–0 | 100% | 1–0 | 1–0 | – | – | Won (6–4, 6–4) at 2021 French Open |
| Roberta Vinci | 2009–2015 | 4–1 | 80% | 2–1 | 1–0 | 1–0 | – | Lost (6–2, 4–6, 4–6) at 2015 US Open |
| Marion Bartoli | 2003–2011 | 3–1 | 75% | 3–0 | – | 0–1 | – | Won (7–5, 6–1) at 2011 Stanford |
| Irina Spîrlea | 1998–1999 | 3–1 | 75% | 2–1 | 1–0 | – | – | Won (6–2, 6–3) at 1999 Rome |
| Patty Schnyder | 1998–2009 | 8–4 | 67% | 6–0 | 0–3 | – | 2–1 | Lost (2–6, 6–2, 1–6) at 2009 Rome |
| Number 8 ranked players | | | | | | | | |
| Ai Sugiyama | 1998–2008 | 4–0 | 100% | 2–0 | 1–0 | 1–0 | – | Won (6–2, 6–1) at 2008 US Open |
| Anna Kournikova | 2000–2002 | 2–0 | 100% | 2–0 | – | – | – | Won (6–2, 4–6, 6–3) at 2002 Sydney |
| Alicia Molik | 1999–2007 | 2–0 | 100% | 1–0 | – | 1–0 | – | Won (7–6$^{(7–4)}$, 6–3) at 2007 Wimbledon |
| Daria Kasatkina | 2016 | 1–0 | 100% | 1–0 | – | – | – | Won (6–1, 6–1) at 2016 Australian Open |
| Karolína Muchová | 2019 | 1–0 | 100% | 1–0 | – | – | – | Won (6–3, 6–2) at 2019 US Open |
| Ekaterina Makarova | 2009–2016 | 5–1 | 83% | 5–1 | – | – | – | Won (6–3, 6–3) at 2016 US Open |
| Number 9 ranked players | | | | | | | | |
| Julia Görges | 2010–2019 | 5–0 | 100% | 1–0 | 2–0 | 2–0 | – | Won (6–3, 6–4) at 2019 Wimbledon |
| Andrea Petkovic | 2010–2015 | 5–0 | 100% | 3–0 | 2–0 | – | – | Won (6–3, 6–2) at 2015 Toronto |
| Timea Bacsinszky | 2010–2015 | 3–0 | 100% | 1–0 | 2–0 | – | – | Won (4–6, 6–3, 6–0) at 2015 French Open |
| CoCo Vandeweghe | 2012–2014 | 3–0 | 100% | 3–0 | – | – | – | Won (6–3, 6–1) at 2014 Miami |
| Sandrine Testud | 1998–2001 | 5–3 | 63% | 4–3 | – | – | 1–0 | Won (6–3, 6–0) at 2001 WTA Finals |
| Dominique Monami | 1997–1998 | 1–1 | 50% | – | 1–0 | – | 0–1 | Won (6–1, 6–1) at 1998 French Open |
| Paola Suárez | 2000 | 0–1 | 0% | – | 0–1 | – | – | Lost (3–6, 6–4, 2–5 ret.) at 2000 Amelia Island |
| Number 10 ranked players | | | | | | | | |
| Maria Kirilenko | 2004–2013 | 8–0 | 100% | 4–0 | 3–0 | 1–0 | – | Won (7–5, 7–5) at 2013 Beijing |
| Kristina Mladenovic | 2016–2018 | 2–0 | 100% | – | 1–0 | 1–0 | – | Won (7–5, 7–6$^{(7–2)}$) at 2018 Wimbledon |
| Barbara Paulus | 1998 | 1–0 | 100% | 1–0 | – | – | – | Won (6–3, 6–2) at 1998 Miami |
| Emma Raducanu | 2022 | 0–1 | 0% | 0–1 | – | – | – | Lost (4–6, 0–6) at 2022 Cincinnati |
| Total | 1997–2022 | 437–123 | 78% | 290–79 (79%) | 81–30 (73%) | 50–10 (83%) | 16–4 (80%) | Current as of 5 March 2025. |

### Record against No. 11–20 players

Williams's record against players who have been ranked world No. 11–20.
* Anastasia Pavlyuchenkova 6–0
* Zheng Jie 6–0
* Tamarine Tanasugarn 6–0
* Eleni Daniilidou 5–0
* Nathalie Dechy 5–0
* Kaia Kanepi 5–0
* Shahar Pe'er 5–0
* Elena Vesnina 5–0
* Daria Gavrilova 4–0
* María José Martínez Sánchez 4–0
* Barbora Strýcová 4–0
* Klára Koukalová 4–1
* Elena Likhovtseva 4–1
* Magüi Serna 4–1
* Alizé Cornet 4–3
* Dája Bedáňová 3–0
* Alona Bondarenko 3–0
* Amy Frazier 3–0
* Varvara Lepchenko 3–0
* Mirjana Lučić-Baroni 3–0
* Peng Shuai 3–0
* Sabine Lisicki 3–1
* Katarina Srebotnik 3–1
* Sabine Appelmans 2–0
* Elena Bovina 2–0
* Tatiana Golovin 2–0
* Anabel Medina Garrigues 2–0
* Tatiana Panova 2–0
* Lisa Raymond 2–0
* Aravane Rezaï 2–0
* Magdaléna Rybáriková 2–0
* Anna Smashnova 2–0
* Karolina Šprem 2–0
* Iroda Tulyaganova 2–0
* Meghann Shaughnessy 2–1
* Ekaterina Alexandrova 1–0
* Amanda Anisimova 1–0
* Ruxandra Dragomir 1–0
* Kirsten Flipkens 1–0
* Inés Gorrochategui 1–0
* Anne Kremer 1–0
* Magda Linette 1–0
* Petra Martić 1–0
* Elise Mertens 1–0
* Larisa Neiland 1–0
* Alison Riske-Amritraj 1–0
* Naoko Sawamatsu 1–0
* Alexandra Stevenson 1–0
* Silvija Talaja 1–0
* Silvia Farina Elia 1–1
* Kimberly Po 1–1
* Wang Qiang 1–1
* Anastasija Sevastova 1–1
* Virginie Razzano 0–1
* Sybille Bammer 0–2
    * Statistics correct as of 5 March 2025.

## Wins over top ranked players
### No. 1 wins

| # | Player | Event | Surface | Round | Score | Result |
| 1. | Martina Hingis | 1999 Miami Open, United States | Hard | Semifinals | 6–4, 7–6$^{(7–3)}$ | Final |
| 2. | Martina Hingis | 1999 Acura Classic, United States | Hard | Semifinals | 6–3, 7–5 | Winner |
| 3. | Martina Hingis | 1999 US Open, New York, United States | Hard | Final | 6–3, 7–6$^{(7–4)}$ | Winner |
| 4. | Martina Hingis | 2000 estyle.com Classic, United States | Hard | Semifinals | 4–6, 6–2, 6–3 | Winner |
| 5. | Martina Hingis | 2001 US Open, New York, United States | Hard | Semifinals | 6–3, 6–2 | Final |
| 6. | Jennifer Capriati | 2002 Miami Open, United States | Hard | Final | 7–5, 7–6$^{(7–4)}$ | Winner |
| 7. | Jennifer Capriati | 2002 French Open, Paris, France | Clay | Semifinals | 3–6, 7–6$^{(7–2)}$, 6–2 | Winner |
| 8. | Venus Williams | 2002 Wimbledon, London, United Kingdom | Grass | Final | 7–6$^{(7–4)}$, 6–3 | Winner |
| 9. | Lindsay Davenport | 2005 Australian Open, Melbourne, Australia | Hard | Final | 2–6, 6–3, 6–0 | Winner |
| 10. | Justine Henin | 2007 Miami Open, United States | Hard | Final | 0–6, 7–5, 6–3 | Winner |
| 11. | Justine Henin | 2008 Miami Open, United States | Hard | Quarterfinals | 6–2, 6–0 | Winner |
| 12. | Caroline Wozniacki | 2011 US Open, New York, United States | Hard | Semifinals | 6–2, 6–4 | Final |
| 13. | Victoria Azarenka | 2012 Madrid Open, Spain | Clay (Blue) | Final | 6–1, 6–3 | Winner |
| 14. | Victoria Azarenka | 2012 Summer Olympics, London, United Kingdom | Grass | Semifinals | 6–1, 6–2 | Winner |
| 15. | Victoria Azarenka | 2012 US Open, New York, United States | Hard | Final | 6–2, 2–6, 7–5 | Winner |
| 16. | Victoria Azarenka | 2012 WTA Tour Championships, İstanbul, Turkey | Hard (i) | Round robin | 6–4, 6–4 | Winner |
| 17. | Simona Halep | 2019 Australian Open, Melbourne, Australia | Hard | 4th round | 6–1, 4–6, 6–4 | Quarterfinals |

## Top 10 wins

Williams has a 178–72 record against players who were, at the time the match was played, ranked in the top 10.
| Season | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | Total |
| Wins | 0 | 0 | 2 | 5 | 14 | 5 | 7 | 17 | 10 | 8 | 3 | 0 | 7 | 9 | 14 | 1 | 5 | 18 | 21 | 12 | 6 | 6 | 1 | 1 | 3 | 0 | 2 | 1 | 178 |
| # | Player | Rank | Event | Surface | Rd | Score | SWR |
| 1997 ||||||||
| 1. | Mary Pierce | No. 7 | Chicago, US | Carpet (i) | 2R | 6–3, 7–6$^{(7–3)}$ | No. 304 |
| 2. | Monica Seles | No. 4 | Chicago, US | Carpet (i) | QF | 4–6, 6–1, 6–1 | No. 304 |
| 1998 ||||||||
| 3. | Lindsay Davenport | No. 3 | Sydney, Australia | Hard | QF | 1–6, 7–5, 7–5 | No. 96 |
| 4. | Irina Spîrlea | No. 9 | Australian Open, Melbourne | Hard | 1R | 6–7$^{(7–9)}$, 6–3, 6–1 | No. 53 |
| 5. | Irina Spîrlea | No. 10 | Miami, US | Hard | 2R | 7–6$^{(7–4)}$, 6–0 | No. 40 |
| 6. | Conchita Martínez | No. 8 | Rome, Italy | Clay | 3R | 6–2, 6–2 | No. 31 |
| 7. | Jana Novotná | No. 3 | Filderstadt, Germany | Hard (i) | 2R | 2–6, 6–3, 2–0 ret. | No. 19 |
| 1999 ||||||||
| 8. | Nathalie Tauziat | No. 9 | Paris, France | Carpet (i) | 2R | 6–1, 6–4 | No. 24 |
| 9. | Lindsay Davenport | No. 2 | Indian Wells, US | Hard | 2R | 6–4, 6–2 | No. 21 |
| 10. | Mary Pierce | No. 8 | Indian Wells, US | Hard | QF | 7–5, 7–6$^{(7–1)}$ | No. 21 |
| 11. | Steffi Graf | No. 7 | Indian Wells, US | Hard | F | 6–3, 3–6, 7–5 | No. 21 |
| 12. | Monica Seles | No. 3 | Miami, US | Hard | 4R | 6–2, 6–3 | No. 16 |
| 13. | Amanda Coetzer | No. 9 | Miami, US | Hard | QF | 6–4, 6–0 | No. 16 |
| 14. | Martina Hingis | No. 1 | Miami, US | Hard | SF | 6–4, 7–6$^{(7–3)}$ | No. 16 |
| 15. | Arantxa Sánchez Vicario | No. 8 | Los Angeles, US | Hard | QF | 6–2, 6–3 | No. 11 |
| 16. | Martina Hingis | No. 1 | Los Angeles, US | Hard | SF | 6–3, 7–5 | No. 11 |
| 17. | Monica Seles | No. 4 | US Open, New York | Hard | QF | 4–6, 6–3, 6–2 | No. 6 |
| 18. | Lindsay Davenport | No. 2 | US Open, New York | Hard | SF | 6–4, 1–6, 6–4 | No. 6 |
| 19. | Martina Hingis | No. 1 | US Open, New York | Hard | F | 6–3, 7–6$^{(7–4)}$ | No. 6 |
| 20. | Lindsay Davenport | No. 2 | Grand Slam Cup, Munich | Hard (i) | SF | 6–3, 6–4 | No. 4 |
| 21. | Venus Williams | No. 3 | Grand Slam Cup, Munich | Hard (i) | F | 6–1, 3–6, 6–3 | No. 4 |
| 2000 ||||||||
| 22. | Julie Halard-Decugis | No. 8 | Paris, France | Carpet (i) | SF | 6–4, 6–2 | No. 4 |
| 23. | Conchita Martínez | No. 6 | Los Angeles, US | Hard | QF | 6–2, 4–6, 6–2 | No. 7 |
| 24. | Martina Hingis | No. 1 | Los Angeles, US | Hard | SF | 4–6, 6–2, 6–3 | No. 7 |
| 25. | Lindsay Davenport | No. 2 | Los Angeles, US | Hard | F | 4–6, 6–4, 7–6$^{(7–1)}$ | No. 7 |
| 26. | Arantxa Sánchez Vicario | No. 9 | Montreal, Canada | Hard | SF | 6–2, 6–4 | No. 7 |
| 2001 ||||||||
| 27. | Lindsay Davenport | No. 2 | Indian Wells, US | Hard | QF | 6–1, 6–2 | No. 10 |
| 28. | Monica Seles | No. 8 | Toronto, Canada | Hard | SF | 7–5, 7–6$^{(7–5)}$ | No. 10 |
| 29. | Jennifer Capriati | No. 3 | Toronto, Canada | Hard | F | 6–1, 6–7$^{(9–11)}$, 6–3 | No. 10 |
| 30. | Justine Henin | No. 6 | US Open, New York | Hard | 4R | 7–5, 6–0 | No. 10 |
| 31. | Lindsay Davenport | No. 3 | US Open, New York | Hard | QF | 6–3, 6–7$^{(9–11)}$, 7–5 | No. 10 |
| 32. | Martina Hingis | No. 1 | US Open, New York | Hard | SF | 6–3, 6–2 | No. 10 |
| 33. | Justine Henin | No. 6 | WTA Tour Championships, Munich | Carpet (i) | QF | 6–3, 7–6$^{(7–5)}$ | No. 10 |
| 2002 ||||||||
| 34. | Amélie Mauresmo | No. 9 | Sydney, Australia | Hard | QF | 6–4, 7–6$^{(8–6)}$ | No. 6 |
| 35. | Martina Hingis | No. 5 | Scottsdale, US | Hard | SF | 6–1, 3–6, 6–4 | No. 9 |
| 36. | Jennifer Capriati | No. 2 | Scottsdale, US | Hard | F | 6–2, 4–6, 6–4 | No. 9 |
| 37. | Martina Hingis | No. 3 | Miami, US | Hard | QF | 6–4, 6–0 | No. 9 |
| 38. | Venus Williams | No. 2 | Miami, US | Hard | SF | 6–2, 6–2 | No. 9 |
| 39. | Jennifer Capriati | No. 1 | Miami, US | Hard | F | 7–5, 7–6$^{(7–4)}$ | No. 9 |
| 40. | Jennifer Capriati | No. 2 | Rome, Italy | Clay | SF | 6–2, 3–6, 7–5 | No. 4 |
| 41. | Justine Henin | No. 8 | Rome, Italy | Clay | F | 7–6$^{(8–6)}$, 6–4 | No. 4 |
| 42. | Jennifer Capriati | No. 1 | French Open, Paris | Clay | SF | 3–6, 7–6$^{(7–2)}$, 6–2 | No. 3 |
| 43. | Venus Williams | No. 2 | French Open, Paris | Clay | F | 7–5, 6–3 | No. 3 |
| 44. | Venus Williams | No. 1 | Wimbledon, London | Grass | F | 7–6$^{(7–4)}$, 6–3 | No. 2 |
| 45. | Lindsay Davenport | No. 10 | US Open, New York | Hard | SF | 6–3, 7–5 | No. 1 |
| 46. | Venus Williams | No. 2 | US Open, New York | Hard | F | 6–4, 6–3 | No. 1 |
| 47. | Kim Clijsters | No. 8 | Tokyo, Japan | Hard | F | 2–6, 6–3, 6–3 | No. 1 |
| 48. | Justine Henin | No. 7 | Leipzig, Germany | Carpet (i) | SF | 6–4, 6–2 | No. 1 |
| 49. | Jelena Dokic | No. 9 | WTA Tour Championships, Los Angeles | Hard (i) | QF | 7–6$^{(7–1)}$, 6–0 | No. 1 |
| 50. | Jennifer Capriati | No. 3 | WTA Tour Championships, Los Angeles | Hard (i) | SF | 2–6, 6–4, 6–4 | No. 1 |
| 2003 ||||||||
| 51. | Kim Clijsters | No. 4 | Australian Open, Melbourne, Australia | Hard | SF | 4–6, 6–3, 7–5 | No. 1 |
| 52. | Venus Williams | No. 2 | Australian Open, Melbourne | Hard | F | 7–6$^{(7–4)}$, 3–6, 6–4 | No. 1 |
| 53. | Amélie Mauresmo | No. 7 | Paris, France | Carpet (i) | F | 6–3, 6–2 | No. 1 |
| 54. | Kim Clijsters | No. 3 | Miami, US | Hard | SF | 6–4, 6–2 | No. 1 |
| 55. | Jennifer Capriati | No. 5 | Miami, US | Hard | F | 4–6, 6–4, 6–1 | No. 1 |
| 56. | Lindsay Davenport | No. 5 | Charleston, US | Clay (green) | SF | 6–1, 7–5 | No. 1 |
| 57. | Amélie Mauresmo | No. 5 | French Open, Paris | Clay | QF | 6–1, 6–2 | No. 1 |
| 58. | Jennifer Capriati | No. 7 | Wimbledon, London | Grass | QF | 2–6, 6–2, 6–3 | No. 1 |
| 59. | Justine Henin | No. 3 | Wimbledon, London | Grass | SF | 6–2, 6–2 | No. 1 |
| 60. | Venus Williams | No. 4 | Wimbledon, London | Grass | F | 4–6, 6–4, 6–2 | No. 1 |
| 2004 ||||||||
| 61. | Elena Dementieva | No. 8 | Miami, US | Hard | F | 6–1, 6–1 | No. 6 |
| 62. | Jennifer Capriati | No. 7 | Wimbledon, London | Grass | QF | 6–1, 6–1 | No. 10 |
| 63. | Amélie Mauresmo | No. 4 | Wimbledon, London | Grass | SF | 6–7$^{(7–9)}$, 7–5, 6–4 | No. 10 |
| 64. | Elena Dementieva | No. 6 | Los Angeles, US | Hard | SF | 6–3, 7–6$^{(7–2)}$ | No. 16 |
| 65. | Svetlana Kuznetsova | No. 5 | Beijing, China | Hard | F | 4–6, 7–5, 6–4 | No. 10 |
| 66. | Elena Dementieva | No. 5 | WTA Tour Championships, Los Angeles | Hard (i) | RR | 7–6$^{(7–3)}$, 7–5 | No. 8 |
| 67. | Anastasia Myskina | No. 3 | WTA Tour Championships, Los Angeles | Hard (i) | RR | 4–6, 6–3, 6–4 | No. 8 |
| 68. | Amélie Mauresmo | No. 2 | WTA Tour Championships, Los Angeles | Hard (i) | SF | 4–6, 7–6$^{(7–2)}$, 6–4 | No. 8 |
| 2005 ||||||||
| 69. | Amélie Mauresmo | No. 2 | Australian Open, Melbourne | Hard | QF | 6–2, 6–2 | No. 7 |
| 70. | Maria Sharapova | No. 4 | Australian Open, Melbourne | Hard | SF | 2–6, 7–5, 8–6 | No. 7 |
| 71. | Lindsay Davenport | No. 1 | Australian Open, Melbourne | Hard | F | 2–6, 6–3, 6–0 | No. 7 |
| 2007 ||||||||
| 72. | Nadia Petrova | No. 6 | Australian Open, Melbourne | Hard | 3R | 1–6, 7–5, 6–3 | No. 81 |
| 73. | Maria Sharapova | No. 2 | Australian Open, Melbourne | Hard | F | 6–1, 6–2 | No. 81 |
| 74. | Maria Sharapova | No. 2 | Miami, US | Hard | 4R | 6–1, 6–1 | No. 18 |
| 75. | Nicole Vaidišová | No. 8 | Miami, US | Hard | QF | 6–1, 6–4 | No. 18 |
| 76. | Justine Henin | No. 1 | Miami, US | Hard | F | 0–6, 7–5, 6–3 | No. 18 |
| 77. | Marion Bartoli | No. 10 | US Open, New York | Hard | 4R | 6–3, 6–4 | No. 9 |
| 78. | Svetlana Kuznetsova | No. 2 | Moscow, Russia | Carpet (i) | SF | 7–6$^{(7–2)}$, 6–1 | No. 7 |
| 2008 ||||||||
| 79. | Venus Williams | No. 7 | Bangalore, India | Hard | SF | 6–3, 3–6, 7–6$^{(7–4)}$ | No. 11 |
| 80. | Justine Henin | No. 1 | Miami, US | Hard | QF | 6–2, 6–0 | No. 8 |
| 81. | Svetlana Kuznetsova | No. 4 | Miami, US | Hard | SF | 3–6, 7–5, 6–3 | No. 8 |
| 82. | Jelena Janković | No. 3 | Miami, US | Hard | F | 6–1, 5–7, 6–3 | No. 8 |
| 83. | Maria Sharapova | No. 4 | Charleston, US | Clay (green) | QF | 7–5, 4–6, 6–1 | No. 9 |
| 84. | Venus Williams | No. 8 | US Open, New York | Hard | QF | 7–6$^{(8–6)}$, 7–6$^{(9–7)}$ | No. 3 |
| 85. | Dinara Safina | No. 7 | US Open, New York | Hard | SF | 6–3, 6–2 | No. 3 |
| 86. | Jelena Janković | No. 2 | US Open, New York | Hard | F | 6–4, 7–5 | No. 3 |
| 87. | Dinara Safina | No. 2 | WTA Tour Championships, Doha | Hard | RR | 6–4, 6–1 | No. 3 |
| 2009 ||||||||
| 88. | Svetlana Kuznetsova | No. 8 | Australian Open, Melbourne | Hard | QF | 5–7, 7–5, 6–1 | No. 2 |
| 89. | Elena Dementieva | No. 4 | Australian Open, Melbourne | Hard | SF | 6–3, 6–4 | No. 2 |
| 90. | Dinara Safina | No. 3 | Australian Open, Melbourne | Hard | F | 6–0, 6–3 | No. 2 |
| 91. | Ana Ivanovic | No. 8 | Dubai, UAE | Hard | QF | 6–4, 6–4 | No. 1 |
| 92. | Venus Williams | No. 6 | Miami, US | Hard | SF | 6–4, 3–6, 6–3 | No. 1 |
| 93. | Victoria Azarenka | No. 8 | Wimbledon, London | Grass | QF | 6–2, 6–3 | No. 2 |
| 94. | Elena Dementieva | No. 4 | Wimbledon, London | Grass | SF | 6–7$^{(7–9)}$, 7–5, 8–6 | No. 2 |
| 95. | Venus Williams | No. 3 | Wimbledon, London | Grass | F | 7–6$^{(7–3)}$, 6–2 | No. 2 |
| 96. | Flavia Pennetta | No. 10 | US Open, New York, US | Hard | QF | 6–4, 6–3 | No. 2 |
| 97. | Svetlana Kuznetsova | No. 3 | WTA Tour Championships, Doha | Hard | RR | 7–6$^{(8–6)}$, 7–5 | No. 2 |
| 98. | Elena Dementieva | No. 5 | WTA Tour Championships, Doha | Hard | RR | 6–2, 6–4 | No. 2 |
| 99. | Venus Williams | No. 7 | WTA Tour Championships, Doha | Hard | RR | 5–7, 6–4, 7–6$^{(7–4)}$ | No. 2 |
| 100. | Caroline Wozniacki | No. 4 | WTA Tour Championships, Doha | Hard | SF | 6–4, 0–1 ret. | No. 2 |
| 101. | Venus Williams | No. 7 | WTA Tour Championships, Doha | Hard | F | 6–2, 7–6$^{(7–4)}$ | No. 2 |
| 2010 ||||||||
| 102. | Victoria Azarenka | No. 7 | Australian Open, Melbourne | Hard | QF | 4–6, 7–6$^{(7–4)}$, 6–2 | No. 1 |
| 2011 ||||||||
| 103. | Maria Sharapova | No. 5 | Stanford, US | Hard | QF | 6–1, 6–3 | No. 169 |
| 104. | Marion Bartoli | No. 9 | Stanford, US | Hard | F | 7–5, 6–1 | No. 169 |
| 105. | Victoria Azarenka | No. 4 | Toronto, Canada | Hard | SF | 6–3, 6–3 | No. 80 |
| 106. | Victoria Azarenka | No. 5 | US Open, New York | Hard | 3R | 6–1, 7–6$^{(7–5)}$ | No. 27 |
| 107. | Caroline Wozniacki | No. 1 | US Open, New York | Hard | SF | 6–2, 6–4 | No. 27 |
| 2012 ||||||||
| 108. | Samantha Stosur | No. 5 | Miami, US | Hard | 4R | 7–5, 6–3 | No. 11 |
| 109. | Samantha Stosur | No. 5 | Charleston, US | Clay (green) | SF | 6–1, 6–1 | No. 10 |
| 110. | Caroline Wozniacki | No. 6 | Madrid, Spain | Clay (blue) | 3R | 1–6, 6–3, 6–2 | No. 9 |
| 111. | Maria Sharapova | No. 2 | Madrid, Spain | Clay (blue) | QF | 6–1, 6–3 | No. 9 |
| 112. | Victoria Azarenka | No. 1 | Madrid, Spain | Clay (blue) | F | 6–1, 6–3 | No. 9 |
| 113. | Petra Kvitová | No. 4 | Wimbledon, London | Grass | QF | 6–3, 7–5 | No. 6 |
| 114. | Victoria Azarenka | No. 2 | Wimbledon, London | Grass | SF | 6–3, 7–6$^{(8–6)}$ | No. 6 |
| 115. | Agnieszka Radwańska | No. 3 | Wimbledon, London | Grass | F | 6–1, 5–7, 6–2 | No. 6 |
| 116. | Caroline Wozniacki | No. 8 | Summer Olympics, London | Grass | QF | 6–0, 6–3 | No. 4 |
| 117. | Victoria Azarenka | No. 1 | Summer Olympics, London | Grass | SF | 6–1, 6–2 | No. 4 |
| 118. | Maria Sharapova | No. 3 | Summer Olympics, London | Grass | F | 6–0, 6–1 | No. 4 |
| 119. | Sara Errani | No. 10 | US Open, New York | Hard | SF | 6–1, 6–2 | No. 4 |
| 120. | Victoria Azarenka | No. 1 | US Open, New York | Hard | F | 6–2, 2–6, 7–5 | No. 4 |
| 121. | Angelique Kerber | No. 5 | WTA Tour Championships, Istanbul | Hard (i) | RR | 6–4, 6–1 | No. 3 |
| 122. | Li Na | No. 8 | WTA Tour Championships, Istanbul | Hard (i) | RR | 7–6$^{(7–2)}$, 6–3 | No. 3 |
| 123. | Victoria Azarenka | No. 1 | WTA Tour Championships, Istanbul | Hard (i) | RR | 6–4, 6–4 | No. 3 |
| 124. | Agnieszka Radwańska | No. 4 | WTA Tour Championships, Istanbul | Hard (i) | SF | 6–2, 6–1 | No. 3 |
| 125. | Maria Sharapova | No. 2 | WTA Tour Championships, Istanbul | Hard (i) | F | 6–4, 6–3 | No. 3 |
| 2013 ||||||||
| 126. | Petra Kvitová | No. 8 | Doha, Qatar | Hard | QF | 3–6, 6–3, 7–5 | No. 2 |
| 127. | Maria Sharapova | No. 3 | Doha, Qatar | Hard | SF | 6–3, 6–2 | No. 2 |
| 128. | Li Na | No. 5 | Miami, US | Hard | QF | 6–3, 7–6$^{(7–5)}$ | No. 1 |
| 129. | Agnieszka Radwańska | No. 4 | Miami, US | Hard | SF | 6–0, 6–3 | No. 1 |
| 130. | Maria Sharapova | No. 2 | Miami, US | Hard | F | 4–6, 6–3, 6–0 | No. 1 |
| 131. | Sara Errani | No. 7 | Madrid, Spain | Clay | SF | 7–5, 6–2 | No. 1 |
| 132. | Maria Sharapova | No. 2 | Madrid, Spain | Clay | F | 6–1, 6–4 | No. 1 |
| 133. | Victoria Azarenka | No. 3 | Rome, Italy | Clay | F | 6–1, 6–3 | No. 1 |
| 134. | Sara Errani | No. 5 | French Open, Paris | Clay | SF | 6–0, 6–1 | No. 1 |
| 135. | Maria Sharapova | No. 2 | French Open, Paris | Clay | F | 6–4, 6–4 | No. 1 |
| 136. | Agnieszka Radwańska | No. 4 | Toronto, Canada | Hard | SF | 7–6$^{(7–3)}$, 6–4 | No. 1 |
| 137. | Li Na | No. 5 | Cincinnati, US | Hard | SF | 7–5, 7–5 | No. 1 |
| 138. | Li Na | No. 6 | US Open, New York | Hard | SF | 6–0, 6–3 | No. 1 |
| 139. | Victoria Azarenka | No. 2 | US Open, New York | Hard | F | 7–5, 6–7$^{(6–8)}$, 6–1 | No. 1 |
| 140. | Caroline Wozniacki | No. 8 | Beijing, China | Hard | QF | 6–1, 6–4 | No. 1 |
| 141. | Agnieszka Radwańska | No. 4 | Beijing, China | Hard | SF | 6–2, 6–2 | No. 1 |
| 142. | Angelique Kerber | No. 9 | WTA Tour Championships, Istanbul | Hard (i) | RR | 6–3, 6–1 | No. 1 |
| 143. | Agnieszka Radwańska | No. 4 | WTA Tour Championships, Istanbul | Hard (i) | RR | 6–2, 6–4 | No. 1 |
| 144. | Petra Kvitová | No. 6 | WTA Tour Championships, Istanbul | Hard (i) | RR | 6–2, 6–3 | No. 1 |
| 145. | Jelena Janković | No. 8 | WTA Tour Championships, Istanbul | Hard (i) | SF | 6–4, 2–6, 6–4 | No. 1 |
| 146. | Li Na | No. 5 | WTA Tour Championships, Istanbul | Hard (i) | F | 2–6, 6–3, 6–0 | No. 1 |
| 2014 ||||||||
| 147. | Maria Sharapova | No. 4 | Brisbane, Australia | Hard | SF | 6–2, 7–6$^{(9–7)}$ | No. 1 |
| 148. | Victoria Azarenka | No. 2 | Brisbane, Australia | Hard | F | 6–4, 7–5 | No. 1 |
| 149. | Jelena Janković | No. 7 | Dubai, UAE | Hard | QF | 6–2, 6–2 | No. 1 |
| 150. | Angelique Kerber | No. 9 | Miami, US | Hard | QF | 6–2, 6–2 | No. 1 |
| 151. | Maria Sharapova | No. 7 | Miami, US | Hard | SF | 6–4, 6–3 | No. 1 |
| 152. | Li Na | No. 2 | Miami, US | Hard | F | 7–5, 6–1 | No. 1 |
| 153. | Angelique Kerber | No. 8 | Stanford, US | Hard | F | 7–6$^{(7–1)}$, 6–3 | No. 1 |
| 154. | Jelena Janković | No. 9 | Cincinnati, US | Hard | QF | 6–1, 6–3 | No. 1 |
| 155. | Ana Ivanovic | No. 7 | WTA Tour Championships, Singapore | Hard (i) | RR | 6–4, 6–4 | No. 1 |
| 156. | Eugenie Bouchard | No. 5 | WTA Tour Championships, Singapore | Hard (i) | RR | 6–1, 6–1 | No. 1 |
| 157. | Caroline Wozniacki | No. 8 | WTA Tour Championships, Singapore | Hard (i) | SF | 2–6, 6–3, 7–6$^{(8–6)}$ | No. 1 |
| 158. | Simona Halep | No. 4 | WTA Tour Championships, Singapore | Hard (i) | F | 6–3, 6–0 | No. 1 |
| 2015 ||||||||
| 159. | Dominika Cibulková | No. 10 | Australian Open, Melbourne | Hard | QF | 6–2, 6–2 | No. 1 |
| 160. | Maria Sharapova | No. 2 | Australian Open, Melbourne | Hard | F | 6–3, 7–6$^{(7–5)}$ | No. 1 |
| 161. | Simona Halep | No. 3 | Miami, US | Hard | SF | 6–2, 4–6, 7–5 | No. 1 |
| 162. | Maria Sharapova | No. 4 | Wimbledon, London | Grass | SF | 6–2, 6–4 | No. 1 |
| 163. | Ana Ivanovic | No. 9 | Cincinnati, US | Hard | QF | 3–6, 6–4, 6–2 | No. 1 |
| 164. | Simona Halep | No. 3 | Cincinnati, US | Hard | F | 6–3, 7–6$^{(7–5)}$ | No. 1 |
| 2016 ||||||||
| 165. | Maria Sharapova | No. 5 | Australian Open, Melbourne | Hard | QF | 6–4, 6–1 | No. 1 |
| 166. | Agnieszka Radwańska | No. 4 | Australian Open, Melbourne | Hard | SF | 6–0, 6–4 | No. 1 |
| 167. | Simona Halep | No. 5 | Indian Wells, US | Hard | QF | 6–4, 6–3 | No. 1 |
| 168. | Agnieszka Radwańska | No. 3 | Indian Wells, US | Hard | SF | 6–4, 7–6$^{(7–1)}$ | No. 1 |
| 169. | Angelique Kerber | No. 4 | Wimbledon, London | Grass | F | 7–5, 6–3 | No. 1 |
| 170. | Simona Halep | No. 5 | US Open, New York | Hard | QF | 6–2, 4–6, 6–3 | No. 1 |
| 2017 ||||||||
| 171. | Johanna Konta | No. 9 | Australian Open, Melbourne | Hard | QF | 6–2, 6–3 | No. 2 |
| 2018 ||||||||
| 172. | Karolína Plíšková | No. 8 | US Open, New York | Hard | QF | 6–4, 6–3 | No. 26 |
| 2019 ||||||||
| 173. | Simona Halep | No. 1 | Australian Open, Melbourne | Hard | 4R | 6–1, 4–6, 6–4 | No. 16 |
| 174. | Naomi Osaka | No. 2 | Toronto, Canada | Hard | QF | 6–3, 6–4 | No. 10 |
| 175. | Elina Svitolina | No. 5 | US Open, New York | Hard | SF | 6–3, 6–1 | No. 8 |
| 2021 ||||||||
| 176. | Aryna Sabalenka | No. 7 | Australian Open, Melbourne | Hard | 4R | 6–4, 2–6, 6–4 | No. 11 |
| 177. | Simona Halep | No. 2 | Australian Open, Melbourne | Hard | QF | 6–3, 6–3 | No. 11 |
| 2022 ||||||||
| 178. | Anett Kontaveit | No. 2 | US Open, New York | Hard | 2R | 7–6$^{(7–4)}$, 2–6, 6–2 | No. 605 |

## WTA Tour career earnings

| Year | Grand Slam singles titles | WTA singles titles | Total singles titles | Earnings ($) | Money list rank |
| 1995–97 | 0 | 0 | 0 | 28,230 | n/a |
| 1998 | 0 | 0 | 0 | 324,974 | 21 |
| 1999 | 1 | 4 | 5 | 2,605,102 | 3 |
| 2000 | 0 | 3 | 3 | 1,026,818 | 7 |
| 2001 | 0 | 3 | 3 | 2,136,263 | 3 |
| 2002 | 3 | 5 | 8 | 3,935,668 | 1 |
| 2003 | 2 | 2 | 4 | 2,504,871 | 3 |
| 2004 | 0 | 2 | 2 | 2,251,798 | 2 |
| 2005 | 1 | 0 | 1 | 1,076,226 | 12 |
| 2006 | 0 | 0 | 0 | 131,705 | 110 |
| 2007 | 1 | 1 | 2 | 2,102,642 | 3 |
| 2008 | 1 | 3 | 4 | 3,852,173 | 1 |
| 2009 | 2 | 1 | 3 | 6,545,586 | 1 |
| 2010 | 2 | 0 | 2 | 4,266,011 | 3 |
| 2011 | 0 | 2 | 2 | 1,978,930 | 10 |
| 2012 | 2 | 5 | 7 | 7,045,975 | 2 |
| 2013 | 2 | 9 | 11 | 12,385,572 | 1 |
| 2014 | 1 | 6 | 7 | 9,317,298 | 1 |
| 2015 | 3 | 2 | 5 | 10,582,642 | 1 |
| 2016 | 1 | 1 | 2 | 7,675,030 | 2 |
| 2017 | 1 | 0 | 1 | 2,704,680 | 13 |
| 2018 | 0 | 0 | 0 | 3,770,170 | 7 |
| 2019 | 0 | 0 | 0 | 4,310,515 | 5 |
| 2020 | 0 | 1 | 1 | 1,091,151 | 11 |
| 2021 | 0 | 0 | 0 | 884,004 | 30 |
| 2022 | 0 | 0 | 0 | 297,759 | 258 |
| Career | 23 | 50 | 73 | 94,816,730 | 1 |

## Longest winning streaks
### 33-win major streak 2002–03

| Streak no | Tournament | Start date | Surface | Rd | Opponent | Rank | Res | Score |
| Last loss | 2001 US Open | August 27, 2001 | Hard | F | Venus Williams | #4 | L | 2–6, 4–6 |
| 1 | 2002 French Open | May 27, 2002 | Clay | R1 | Martina Suchá | #39 | W | 6–3, 6–0 |
| 2 | 2002 French Open | May 27, 2002 | Clay | R2 | Dally Randriantefy | #169 | W | 6–2, 6–3 |
| 3 | 2002 French Open | May 27, 2002 | Clay | R3 | Janette Husárová | #41 | W | 6–1, 6–3 |
| 4 | 2002 French Open | May 27, 2002 | Clay | R4 | Vera Zvonareva | #142 | W | 4–6, 6–0, 6–1 |
| 5 | 2002 French Open | May 27, 2002 | Clay | QF | Mary Pierce | #132 | W | 6–1, 6–1 |
| 6 | 2002 French Open | May 27, 2002 | Clay | SF | Jennifer Capriati | #1 | W | 3–6, 7–6$^{(7–3)}$, 6–2 |
| 7 | 2002 French Open | May 27, 2002 | Clay | W | Venus Williams | #2 | W | 7–5, 6–3 |
| 8 | 2002 Wimbledon | June 24, 2002 | Grass | R1 | Evie Dominikovic | #103 | W | 6–1, 6–1 |
| 9 | 2002 Wimbledon | June 24, 2002 | Grass | R2 | Francesca Schiavone | #45 | W | 6–3, 6–3 |
| 10 | 2002 Wimbledon | June 24, 2002 | Grass | R3 | Els Callens | #119 | W | 7–6$^{(7–5)}$, 7–6$^{(7–2)}$ |
| 11 | 2002 Wimbledon | June 24, 2002 | Grass | R4 | Chanda Rubin | #27 | W | 6–3, 6–3 |
| 12 | 2002 Wimbledon | June 24, 2002 | Grass | QF | Daniela Hantuchová | #12 | W | 6–3, 6–2 |
| 13 | 2002 Wimbledon | June 24, 2002 | Grass | SF | Amélie Mauresmo | #11 | W | 6–1, 6–2 |
| 14 | 2002 Wimbledon | June 24, 2002 | Grass | W | Venus Williams | #1 | W | 7–6$^{(7–4)}$, 6–3 |
| 15 | 2002 US Open | August 26, 2002 | Hard | R1 | Corina Morariu | NR | W | 6–2, 6–3 |
| 16 | 2002 US Open | August 26, 2002 | Hard | R2 | Dinara Safina | #91 | W | 6–0, 6–1 |
| 17 | 2002 US Open | August 26, 2002 | Hard | R3 | Nathalie Dechy | #26 | W | 6–1, 6–1 |
| 18 | 2002 US Open | August 26, 2002 | Hard | R4 | Dája Bedáňová | #24 | W | 6–1, 6–1 |
| 19 | 2002 US Open | August 26, 2002 | Hard | QF | Daniela Hantuchová | #12 | W | 6–2, 6–2 |
| 20 | 2002 US Open | August 26, 2002 | Hard | SF | Lindsay Davenport | #10 | W | 6–3, 7–5 |
| 21 | 2002 US Open | August 26, 2002 | Hard | W | Venus Williams | #2 | W | 6–4, 6–3 |
| 22 | 2003 Australian Open | January 13, 2003 | Hard | R1 | Émilie Loit | #56 | W | 3–6, 7–6$^{(7–5)}$, 7–5 |
| 23 | 2003 Australian Open | January 13, 2003 | Hard | R2 | Els Callens | #66 | W | 6–4, 6–0 |
| 24 | 2003 Australian Open | January 13, 2003 | Hard | R3 | Tamarine Tanasugarn | #32 | W | 6–1, 6–1 |
| 25 | 2003 Australian Open | January 13, 2003 | Hard | R4 | Eleni Daniilidou | #20 | W | 6–4, 6–1 |
| 26 | 2003 Australian Open | January 13, 2003 | Hard | QF | Meghann Shaughnessy | #33 | W | 6–2, 6–2 |
| 27 | 2003 Australian Open | January 13, 2003 | Hard | SF | Kim Clijsters | #4 | W | 4–6, 6–3, 7–5 |
| 28 | 2003 Australian Open | January 13, 2003 | Hard | W | Venus Williams | #2 | W | 7–6$^{(7–4)}$, 3–6, 6–4 |
| 29 | 2003 French Open | May 26, 2003 | Clay | R1 | Barbara Rittner | #87 | W | 6–2, 6–1 |
| 30 | 2003 French Open | May 26, 2003 | Clay | R2 | Marie-Gayanay Mikaelian | #39 | W | 6–3, 6–2 |
| 31 | 2003 French Open | May 26, 2003 | Clay | R3 | Barbara Schett | #51 | W | 6–0, 6–0 |
| 32 | 2003 French Open | May 26, 2003 | Clay | R4 | Ai Sugiyama | #15 | W | 7–5, 6–3 |
| 33 | 2003 French Open | May 26, 2003 | Clay | QF | Amélie Mauresmo | #5 | W | 6–1, 6–2 |
| End of streak | 2003 French Open | May 26, 2003 | Clay | SF | Justine Henin-Hardenne | #4 | L | 2–6, 6–4, 5–7 |

### 34-win streak 2013

| No. | Match | Tournament | Start date | Category | Surface | Rd | Opponent | Rank | Score |
| – | 676 | Qatar Total Open | 11 February | Premier 5 | Hard | F | Victoria Azarenka | #1 | 6–7$^{(6–8)}$, 6–2, 3–6 |
| 1 | 677 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | 2R | Flavia Pennetta | #103 | 6–1, 6–1 |
| 2 | 678 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | 3R | Ayumi Morita | #50 | 6–3, 6–3 |
| 3 | 679 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | 4R | Dominika Cibulková | #14 | 2–6, 6–4, 6–2 |
| 4 | 680 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | QF | Li Na | #5 | 6–3, 7–6$^{(7–5)}$ |
| 5 | 681 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | SF | Agnieszka Radwańska | #4 | 6–0, 6–3 |
| 6 | 682 | Sony Open Tennis | 18 March | Premier Mandatory | Hard | F | Maria Sharapova | #2 | 4–6, 6–3, 6–0 |
| 7 | 683 | Family Circle Cup | 1 April | Premier | Clay (green) | 2R | Camila Giorgi | #85 | 6–2, 6–3 |
| 8 | 684 | Family Circle Cup | 1 April | Premier | Clay (green) | 3R | Mallory Burdette | #99 | 6–4, 6–2 |
| 9 | 685 | Family Circle Cup | 1 April | Premier | Clay (green) | QF | Lucie Šafářová | #19 | 6–4, 6–1 |
| 10 | 686 | Family Circle Cup | 1 April | Premier | Clay (green) | SF | Venus Williams | #24 | 6–1, 6–2 |
| 11 | 687 | Family Circle Cup | 1 April | Premier | Clay (green) | F | Jelena Janković | #18 | 3–6, 6–0, 6–2 |
| 12 | 688 | Fed Cup | 20 April | Team Event | Hard | – | Johanna Larsson | #66 | 6–2, 6–2 |
| 13 | 689 | Fed Cup | 20 April | Team Event | Hard | – | Sofia Arvidsson | #54 | 6–2, 6–1 |
| 14 | 690 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | 1R | Yulia Putintseva | #88 | 7–6$^{(7–5)}$, 6–1 |
| 15 | 691 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | 2R | Lourdes Domínguez Lino | #47 | 6–2, 7–5 |
| 16 | 692 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | 3R | Maria Kirilenko | #12 | 6–3, 6–1 |
| 17 | 693 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | QF | Anabel Medina Garrigues | #63 | 6–3, 0–6, 7–5 |
| 18 | 694 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | SF | Sara Errani | #7 | 7–5, 6–2 |
| 19 | 695 | Mutua Madrid Open | 6 May | Premier Mandatory | Clay | F | Maria Sharapova | #2 | 6–1, 6–4 |
| 20 | 696 | Italian Open | 13 May | Premier 5 | Clay | 2R | Laura Robson | #39 | 6–2, 6–2 |
| 21 | 697 | Italian Open | 13 May | Premier 5 | Clay | 3R | Dominika Cibulková | #16 | 6–0, 6–1 |
| 22 | 698 | Italian Open | 13 May | Premier 5 | Clay | QF | Carla Suárez Navarro | #22 | 6–2, 6–0 |
| 23 | 699 | Italian Open | 13 May | Premier 5 | Clay | SF | Simona Halep | #64 | 6–3, 6–0 |
| 24 | 700 | Italian Open | 13 May | Premier 5 | Clay | F | Victoria Azarenka | #3 | 6–1, 6–3 |
| 25 | 701 | French Open | 26 May | Grand Slam | Clay | 1R | Anna Tatishvili | #83 | 6–0, 6–1 |
| 26 | 702 | French Open | 26 May | Grand Slam | Clay | 2R | Caroline Garcia | #113 | 6–1, 6–2 |
| 27 | 703 | French Open | 26 May | Grand Slam | Clay | 3R | Sorana Cîrstea | #26 | 6–0, 6–2 |
| 28 | 704 | French Open | 26 May | Grand Slam | Clay | 4R | Roberta Vinci | #15 | 6–1, 6–3 |
| 29 | 705 | French Open | 26 May | Grand Slam | Clay | QF | Svetlana Kuznetsova | #39 | 6–1, 3–6, 6–3 |
| 30 | 706 | French Open | 26 May | Grand Slam | Clay | SF | Sara Errani | #5 | 6–0, 6–1 |
| 31 | 707 | French Open | 26 May | Grand Slam | Clay | F | Maria Sharapova | #2 | 6–4, 6–4 |
| 32 | 708 | Wimbledon Championships | 24 June | Grand Slam | Grass | 1R | Mandy Minella | #92 | 6–1, 6–3 |
| 33 | 709 | Wimbledon Championships | 24 June | Grand Slam | Grass | 2R | Caroline Garcia | #100 | 6–3, 6–2 |
| 34 | 710 | Wimbledon Championships | 24 June | Grand Slam | Grass | 3R | Kimiko Date-Krumm | #84 | 6–2, 6–0 |
| – | 711 | Wimbledon Championships | 24 June | Grand Slam | Grass | 4R | Sabine Lisicki | #23 | 2–6, 6–1, 4–6 |

### 33-win major streak 2014–15

| Streak no | Tournament | Start date | Surface | Rd | Opponent | Rank | Res | Score |
| Last loss | 2014 Wimbledon | June 23, 2014 | Hard | R3 | Alizé Cornet | #25 | L | 6–1, 3–6, 4–6 |
| 1 | 2014 US Open | August 25, 2014 | Hard | R1 | Taylor Townsend | #103 | W | 6–3, 6–1 |
| 2 | 2014 US Open | August 25, 2014 | Hard | R2 | Vania King | #81 | W | 6–1, 6–0 |
| 3 | 2014 US Open | August 25, 2014 | Hard | R3 | Varvara Lepchenko | #52 | W | 6–3, 6–3 |
| 4 | 2014 US Open | August 25, 2014 | Hard | R4 | Kaia Kanepi | #50 | W | 6–3, 6–3 |
| 5 | 2014 US Open | August 25, 2014 | Hard | QF | Flavia Pennetta | #12 | W | 6–3, 6–2 |
| 6 | 2014 US Open | August 25, 2014 | Hard | SF | Ekaterina Makarova | #18 | W | 6–1, 6–3 |
| 7 | 2014 US Open | August 25, 2014 | Hard | W | Caroline Wozniacki | #11 | W | 6–3, 6–3 |
| 8 | 2015 Australian Open | January 19, 2015 | Hard | R1 | Alison Van Uytvanck | #106 | W | 6–0, 6–4 |
| 9 | 2015 Australian Open | January 19, 2015 | Hard | R2 | Vera Zvonareva | #203 | W | 7–5, 6–0 |
| 10 | 2015 Australian Open | January 19, 2015 | Hard | R3 | Elina Svitolina | #26 | W | 4–6, 6–2, 6–0 |
| 11 | 2015 Australian Open | January 19, 2015 | Hard | R4 | Garbiñe Muguruza | #24 | W | 2–6, 6–3, 6–2 |
| 12 | 2015 Australian Open | January 19, 2015 | Hard | QF | Dominika Cibulková | #12 | W | 6–2, 6–2 |
| 13 | 2015 Australian Open | January 19, 2015 | Hard | SF | Madison Keys | #35 | W | 7–6$^{(7–5)}$, 6–2 |
| 14 | 2015 Australian Open | January 19, 2015 | Hard | W | Maria Sharapova | #2 | W | 6–3, 7–6$^{(7–5)}$ |
| 15 | 2015 French Open | May 25, 2015 | Clay | R1 | Andrea Hlaváčková | #190 | W | 6–2, 6–3 |
| 16 | 2015 French Open | May 25, 2015 | Clay | R2 | Anna-Lena Friedsam | #105 | W | 5–7, 6–3, 6–3 |
| 17 | 2015 French Open | May 25, 2015 | Clay | R3 | Victoria Azarenka | #27 | W | 3–6, 6–4, 6–2 |
| 18 | 2015 French Open | May 25, 2015 | Clay | R4 | Sloane Stephens | #40 | W | 1–6, 7–5, 6–3 |
| 19 | 2015 French Open | May 25, 2015 | Clay | QF | Sara Errani | #17 | W | 6–1, 6–3 |
| 20 | 2015 French Open | May 25, 2015 | Clay | SF | Timea Bacsinszky | #24 | W | 4–6, 6–3, 6–0 |
| 21 | 2015 French Open | May 25, 2015 | Clay | W | Lucie Šafářová | #13 | W | 6–3, 6–7$^{(2–7)}$, 6–2 |
| 22 | 2015 Wimbledon | June 29, 2015 | Grass | R1 | Margarita Gasparyan | #113 | W | 6–4, 6–1 |
| 23 | 2015 Wimbledon | June 29, 2015 | Grass | R2 | Tímea Babos | #93 | W | 6–4, 6–1 |
| 24 | 2015 Wimbledon | June 29, 2015 | Grass | R3 | Heather Watson | #32 | W | 6–2, 4–6, 7–5 |
| 25 | 2015 Wimbledon | June 29, 2015 | Grass | R4 | Venus Williams | #16 | W | 6–4, 6–3 |
| 26 | 2015 Wimbledon | June 29, 2015 | Grass | QF | Victoria Azarenka | #24 | W | 3–6, 6–2, 6–3 |
| 27 | 2015 Wimbledon | June 29, 2015 | Grass | SF | Maria Sharapova | #4 | W | 6–2, 6–4 |
| 28 | 2015 Wimbledon | June 29, 2015 | Grass | W | Garbiñe Muguruza | #20 | W | 6–4, 6–4 |
| 29 | 2015 US Open | August 31, 2015 | Hard | R1 | Vitalia Diatchenko | #86 | W | 6–0, 2–0 retired |
| 30 | 2015 US Open | August 31, 2015 | Hard | R2 | Kiki Bertens | #110 | W | 7–6$^{(7–5)}$, 6–3 |
| 31 | 2015 US Open | August 31, 2015 | Hard | R3 | Bethanie Mattek-Sands | #101 | W | 3–6, 7–5, 6–0 |
| 32 | 2015 US Open | August 31, 2015 | Hard | R4 | Madison Keys | #19 | W | 6–3, 6–3 |
| 33 | 2015 US Open | August 31, 2015 | Hard | QF | Venus Williams | #23 | W | 6–2, 1–6, 6–3 |
| End of streak | 2015 US Open | August 31, 2015 | Hard | SF | Roberta Vinci | #43 | L | 6–2, 4–6, 4–6 |

## Double bagel matches (6–0, 6–0)

| Outcome | Year | No. | Championship | Surface | Opponent | Rank | Round |
| Quarterfinalist | 1998 | 1. | LA Women's Tennis Championships, USA | Hard | Larisa Neiland | 90 | R32 (first round) |
| Semifinalist | 2003 | 2. | Roland Garros, Paris, France | Clay | Barbara Schett | 51 | R32 (third round) |
| Quarterfinalist | 2007 | 3. | Porsche Tennis Grand Prix, Stuttgart, Germany | Hard | Zuzana Ondrášková | 140 | R32 (first round) |
| Win | 2011 | 4. | Bank of the West Classic, Stanford, USA | Hard | Anastasia Rodionova | 105 | R32 (first round) |
| Win | 2012 | 5. | US Open, New York, USA | Hard | Andrea Hlaváčková | 82 | R16 (fourth round) |
| Quarterfinalist | 2013 | 6. | Australian Open, Melbourne, Australia | Hard | Edina Gallovits-Hall | 110 | R128 (first round) |
| Win | 2013 | 7. | US Open, New York, USA | Hard | Carla Suárez Navarro | 20 | QF |

## Grand Slam tournament seedings

Boldface indicates tournaments won by Williams, while italics indicates she was the runner-up.

### Singles

* Legend
* seeded No. 1 (12 / 23)
* seeded No. 2 (4 / 7)
* seeded No. 3 (1 / 5)
* seeded No. 4–10 (5 / 29)
* seeded No. 11–32 (0 / 8)
* not seeded (1 / 9)
Longest / total :
| 15 | 81 |
| 4 | 81 |
| 1 | 81 |
| 7 | 81 |
| 3 | 81 |
| 5 | 81 |
| Year | Australian Open | French Open | Wimbledon | US Open |
| 1998 | unseeded | unseeded | unseeded | unseeded |
| 1999 | unseeded | 10th | did not play | 7th |
| 2000 | 3rd | did not play | 8th | 5th |
| 2001 | 6th | 6th | 5th | 10th |
| 2002 | did not play | 3rd | 2nd | 1st |
| 2003 | 1st | 1st | 1st | did not play |
| 2004 | did not play | 2nd | 1st | 3rd |
| 2005 | 7th | did not play | 4th | 8th |
| 2006 | 13th | did not play | did not play | wildcard |
| 2007 | Unseeded | 8th | 7th | 8th |
| 2008 | 7th | 5th | 6th | 4th |
| 2009 | 2nd | 2nd | 2nd | 2nd |
| 2010 | 1st | 1st | 1st | did not play |
| 2011 | did not play | did not play | 7th | 28th/Protected Ranking |
| 2012 | 12th | 5th | 6th | 4th |
| 2013 | 3rd | 1st | 1st | 1st |
| 2014 | 1st | 1st | 1st | 1st |
| 2015 | 1st | 1st | 1st | 1st |
| 2016 | 1st | 1st | 1st | 1st |
| 2017 | 2nd | did not play | did not play | did not play |
| 2018 | did not play | protected ranking | 25th/Protected Ranking | 17th |
| 2019 | 16th | 10th | 11th | 8th |
| 2020 | 8th | 6th | tournament cancelled | 3rd |
| 2021 | 10th | 7th | 6th | did not play |
| 2022 | did not play | did not play | wildcard | Protected Ranking |

### Doubles

| Year | Australian Open | French Open | Wimbledon | US Open |
| 1997 | did not play | did not play | did not play | wild card |
| 1998 | not seeded | did not play | not seeded | did not play |
| 1999 | not seeded | 9th (1) | did not play | 5th (2) |
| 2000 | did not play | did not play | 8th (3) | wild card |
| 2001 | wild card (4) | did not play | 4th | 9th |
| 2002 | did not play | did not play | 3rd (5) | did not play |
| 2003 | 1st (6) | did not play | 3rd | did not play |
| 2004 | did not play | did not play | did not play | did not play |
| 2005 | did not play | did not play | did not play | did not play |
| 2006 | did not play | did not play | did not play | did not play |
| 2007 | did not play | did not play | wild card | did not play |
| 2008 | not seeded | did not play | 11th (7) | did not play |
| 2009 | 10th (8) | 5th | 4th (9) | 4th (10) |
| 2010 | 2nd (11) | 1st (12) | 1st | did not play |
| 2011 | did not play | did not play | did not play | did not play |
| 2012 | did not play | did not play | not seeded (13) | wild card |
| 2013 | 12th | 12th | did not play | not seeded |
| 2014 | did not play | did not play | 8th | not seeded |
| 2015 | did not play | did not play | did not play | did not play |
| 2016 | did not play | not seeded | not seeded (14) | did not play |
| 2017 | did not play | did not play | did not play | did not play |
| 2018 | did not play | wild card | did not play | did not play |
| 2019 | did not play | did not play | did not play | did not play |
| 2020 | did not play | did not play | did not play | did not play |
| 2021 | did not play | did not play | did not play | did not play |
| 2022 | did not play | did not play | did not play | wild card |