# 2025 Challenger Città di Lugano – Singles

Otto Virtanen was the defending champion but chose not to defend his title.
Borna Ćorić won the title after defeating Raphaël Collignon 6–3, 6–1 in the final.

## Seeds

* Raphaël Collignon (final)
* Borna Ćorić (champion)
* Luca Van Assche (quarterfinals)
* Alexander Blockx (second round)
* Hugo Grenier (second round)
* Henri Squire (quarterfinals)
* Vilius Gaubas (quarterfinals)
* Liam Draxl (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Raphaël Collignon | 7$^7$ | 4 | 6 | | | | |
| Q | Murphy Cassone | 6$^3$ | 6 | 3 | | | | |
| Q | Murphy Cassone | 6$^3$ | 6 | 3 | 1 | Raphaël Collignon | 3 | 1 |
| | | | | | 2 | Borna Ćorić | 6 | 6 |
| Q | Dino Prižmić | 2 | 4 | | 2 | Borna Ćorić | 6 | 6 |
| 2 | Borna Ćorić | 6 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | R Collignon | 6 | 7 | | | | | | | | | | | | | | | |
| Q | V Sachko | 4 | 5 | | 1 | R Collignon | 6 | 7 | | | | | | | | | | |
| SE | V Durasovic | 6 | 1 | 6 | SE | V Durasovic | 4 | 5 | | | | | | | | | | |
| | B Hassan | 4 | 6 | 4 | | | | | 1 | R Collignon | 6 | 6 | | | | | | |
| | C Chidekh | 3 | 6 | 4 | | | | | 8 | L Draxl | 4 | 4 | | | | | | |
| | E Ruusuvuori | 6 | 3 | 6 | | E Ruusuvuori | 4 | 6$^2$ | | | | | | | | | | |
| Q | R Sakamoto | 4 | 4 | | 8 | L Draxl | 6 | 7$^7$ | | | | | | | | | | |
| 8 | L Draxl | 6 | 6 | | | | | | | | | | | 1 | R Collignon | 7$^7$ | 4 | 6 |
| 3 | L Van Assche | 2 | 6 | 6 | | | | | | | | | | Q | M Cassone | 6$^3$ | 6 | 3 |
| Alt | T-l Wu | 6 | 2 | 0 | 3 | L Van Assche | 6 | 6 | | | | | | | | | | |
| SE | Patrick Zahraj | 2 | 7$^7$ | 3 | | J Choinski | 3 | 1 | | | | | | | | | | |
| | J Choinski | 6 | 6$^3$ | 6 | | | | | 3 | L Van Assche | 6$^2$ | 6 | 6$^4$ | | | | | |
| Q | R Berankis | 1 | 2 | | | | | | Q | M Cassone | 7$^7$ | 0 | 7$^7$ | | | | | |
| Q | M Cassone | 6 | 6 | | Q | M Cassone | 7$^9$ | 7$^8$ | | | | | | | | | | |
| LL | J Cui | 2 | 4 | | 5 | H Grenier | 6$^7$ | 6$^6$ | | | | | | | | | | |
| 5 | H Grenier | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | V Gaubas | 6 | 1 | 6 | | | | | | | | | | | | | |
| PR | D Stricker | 3 | 6 | 2 | 7 | V Gaubas | 6$^2$ | 7 | 6 | | | | | | | | |
| | B Zhukayev | 6 | 6$^{10}$ | 6$^5$ | | M Röttgering | 7$^7$ | 5 | 4 | | | | | | | | |
| | M Röttgering | 4 | 7$^{12}$ | 7$^7$ | | | | | | 7 | V Gaubas | 2 | 3 | | | | |
| Q | D Prižmić | 6 | 6 | | | | | | | Q | D Prižmić | 6 | 6 | | | | |
| WC | J Paul | 3 | 2 | | Q | D Prižmić | 6 | 6 | | | | | | | | | |
| LL | JC Prado Ángelo | 2 | 3 | | 4 | A Blockx | 3 | 2 | | | | | | | | | |
| 4 | A Blockx | 6 | 6 | | | | | | | | | | | Q | D Prižmić | 2 | 4 |
| 6 | H Squire | 6 | 7 | | | | | | | | | | | 2 | B Ćorić | 6 | 6 |
| Alt | A Andreev | 3 | 5 | | 6 | H Squire | 7$^7$ | 6 | | | | | | | | | |
| Q | E Butvilas | 6 | 5 | 6$^4$ | WC | R Bertola | 6$^5$ | 4 | | | | | | | | | |
| WC | R Bertola | 2 | 7 | 7$^7$ | | | | | | 6 | H Squire | 2 | 2 | | | | |
| | A Escoffier | 6 | 6 | | | | | | | 2 | B Ćorić | 6 | 6 | | | | |
| WC | M Brunold | 2 | 3 | | | A Escoffier | 4 | 4 | | | | | | | | | |
| | G Onclin | 4 | 2 | | 2 | B Ćorić | 6 | 6 | | | | | | | | | |
| 2 | B Ćorić | 6 | 6 | | | | | | | | | | | | | | |