OpenLLM-France/wikimedia huggingface dataset:
# NBI-1117568

NBI-1117568 (former developmental code name HTL-0016878) is an investigational antipsychotic drug for schizophrenia that was out-licensed Nexera Pharma in to Neurocrine Biosciences, a United States-based pharmaceutical company. It is administered orally.

## Overview

It is a selective muscarinic acetylcholine M$_4$ receptor agonist that indirectly modulates dopamine as the basis for its putative improvement of schizophrenia. In April 2016, the compound was out-licensed to Allergan, an Irish pharmaceutical company. By September 2017, it had advanced to Phase I clinical trial for the indication of "neuropsychiatric symptoms associated with Alzheimer's disease and other dementias" However, in May 2020, Allergan was acquired by AbbVie, and due to AbbVie's pipeline business decisions, the license was returned to Nexceris in January 2021. In November 2021, the compound was newly out-licensed to Neurocrine Biosciences, a U.S. pharmaceutical company. It has been under development as a treatment for schizophrenia, and as of September 2024, Phase II clinical trials have been completed.

## History

* 2016
** April: The rights to develop and sell NBI-1117568 were transferred from its original developer to Allergan.
* 2017
** September: Allergan initiated Phase I clinical trials for NBI-1117568 to treat "neurobehavioral symptoms related to Alzheimer's disease and other conditions."
* 2021
** January: Allergan returned the rights to NBI-1117568 to Nexera Pharma.
** November: The rights were then transferred to Neurocrine Biosciences, which took over the development of NBI-1117568.
* 2022
** October: Phase II clinical trials began for NBI-1117568 to treat schizophrenia.
* 2024
** April: Neurocrine Biosciences announced that NBI-1117568 had met the requirements of long-term preclinical toxicity tests.
** August: Neurocrine Biosciences released the results of the Phase II clinical trials.

## Clinical trials
### Phase II clinical trial

The Phase II clinical trial was conducted in 15 sites across the U.S. with 200 adult patients diagnosed with schizophrenia. The primary endpoint was assessed by the change in the total score of the Positive and Negative Syndrome Scale (PANSS) after six weeks of treatment. The 20 mg once-daily group showed a statistically significant improvement of 7.5 points compared to the placebo group (improvement of 18.2 points from baseline, p = 0.011, effect size = 0.61). However, the 40 mg once-daily group, 60 mg once-daily group, and 30 mg twice-daily group did not show statistically significant differences compared to the placebo group (p-values: 40 mg group: 0.282, 60 mg group: 0.189, 30 mg twice-daily group: 0.090).

#### Market reaction to phase II clinical trial

With a PANSS improvement of 7.5, NBI-111758 lagged behind xanomeline/trospium (KarXT) (Karuna Therapeutics) with 8.4 and emraclidine (Cerevel Therapeutics) with 12.7, both of which were in clinical trials at the same time. Moreover, the lack of dose-dependency led to disappointment in the stock market. Neurocrine Biosciences' share price dropped 19% on the day following the announcement of the Phase II clinical trial results.
# Zelmer Memorial Airpark

Zelmer Memorial Airpark (FAA LID: 5K1)is a privately owned public use airport located 1 mile south of Palmyra, Illinois, United States.

## Facilities and aircraft

The airport covers 27 acres of land. It has one runway measuring 2900 x 32 ft (884 x 10 m). It is made of asphalt.
There is no fixed-base operator operating at the airport. However, there is a flying club that offers aircraft rental. Fuel is also available at the airport.
For the 12-month period ending March 31, 2020, the airport had 96 aircraft operations per week, or about 5,000 per year. This was 98% general aviation and 2% air taxi. For the same time period, there were 17 aircraft based on the field: 16 single-engine airplanes and 1 ultralight.

## Accidents and incidents

* On September 25, 1994, an experimental Thomas E. Georges Z-Max crashed after takeoff from Zelmer. The pilot reported that the engine lost power as he was climbing through 150 feet. As he attempted to pick a landing site, the airplane stalled and impacted terrain. The probable cause was found to be an inadvertent stall while maneuvering to land. Contributing factors include loss of engine power due to carburetor ice and the unavailability of a carburetor heating system in the aircraft. The sole pilot on board sustained serious injuries.
* On May 2, 2020, a Yakovlev Yak-52 crashed at the airport after performing a low pass above the runway and pitching up for a steep climb, at which point the aircraft entered a roll and pitched straight down. The probable cause of the crash was found to be loss of control during a low-altitude aerobatic maneuver. The sole pilot on board died.
* On May 31, 2020, a Piper Cherokee crashed near the airport, killing all four on board.
# Home Fires (Katz book)

Home Fires: An Intimate Portrait of One Middle-Class Family in Postwar America is a narrative nonfiction book by Don Katz. Originally published in 1992, it was reissued in 2014 in ebook and audiobook formats with a new introduction by Jonathan Alter. The book covers the lives of the Gordons, an American family with many familiar experiences and struggles, including a move from the city to the suburbs, and four rebellious children. One of the grown children, Susan Gordon Lydon, wrote her own memoir in parallel, published the next year: Take The Long Way Home: Memoirs Of A Survivor.

## Summary

Home Fires tells the story of the Gordon family – real people, names unchanged – over nearly five decades, from the end of World War II to the early 1990s. The book chronicles the turbulent postwar era, illuminating the interplay between private life and profound cultural changes. Juxtaposing day-to-day family life with landmark public events, Home Fires is a revealing portrait of the second half of the 20th century in America
Members of the family profiled include siblings composer Ricky Ian Gordon and writer Susan Lydon.

## Reception

Home Fires received widespread critical acclaim. Publishers Weekly described it as a "moving, perceptive social history" and "riveting reading." The New York Times called it "mesmerizing, important" and Glamour called it "a flat-out marvel of reportage." Author Jonathan Alter, who also wrote the introduction for the 2014 edition, wrote "Katz's familial lens on recent history belongs on a shelf with classics. There is Balzac here, and Theodore Dreiser, with a touch of John Gunther, John Dos Passos and William Manchester."

## Awards and honors

Home Fires was nominated for a National Book Critics Circle Award in 1992.
# Ivan Plachkov

Ivan Vasylyovych Plachkov (Ukrainian: Іван Васильович Плачков; born 23 November 1957) is a Ukrainian politician of Bulgarian descent. Plachkov was Ukraine's Minister of Energy in 1999 and again Minister of Fuel and Energy of Ukraine between 2005 and 2006.

## Political activity

In 2021, Plachkov made an analysis of Ukraine's energy sector and called for a review of the electricity market. He said the sector was poorly regulated and heavily reliant on cheap electricity from Russia and Belarus.
# Yoges Muniandy

Yoges a/l A. Muniandy (born 13 November 1988) is a Malaysian footballer who plays as a midfielder for Penang in the Malaysia Premier League.

## Club career
### MISC-MIFA

He help the team to win the 2016 Malaysia FAM Cup with overall scoring 2 goals in the season.

### Penang (loan)

In June 2019, Yoges completed his loan deal to Penang.

## Honours
### Club
#### MISC-MIFA

* Malaysia FAM League: 2016

#### Penang FA

* Malaysia Premier League: 2020
# Zahril Azri

Muhammad Zahril Azri bin Zabri (born 4 February 1999) is a Malaysian footballer who play as a central midfielder for Malaysia A1 Semi-Pro League club, Kuala Lumpur Rovers.

## International career
### Youth

Zahril was part of the national team for the 2017 AFF U-18 Youth Championship that will take place in Yangon, Myanmar. On 26 October 2017, he was selected to play in 2018 AFC U-19 Championship qualification in Paju, South Korea.
Zahril was named in the Malaysia under 19 squad for 2018 AFF U-19 Youth Championship in the Indonesia. He has played in the final against Myanmar which Malaysia win 4–3.
On 15 October 2018, he was named in the under-19 side for the 2018 AFC U-19 Championship.

## Career statistics
### Club

    As of match played 18 June 2024
Appearances and goals by club, season and competition :
| Club | Season | League | League | League | Cup | Cup | League Cup | League Cup | Continental | Continental | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| Felda United | 2018 | Malaysia Premier League | 7 | 0 | 1 | 0 | 7 | 1 | – | – | 15 | 1 |
| Felda United | 2019 | Malaysia Super League | 15 | 1 | 4 | 0 | 1 | 0 | – | – | 20 | 1 |
| Felda United | Total | Total | 22 | 1 | 5 | 0 | 8 | 1 | 0 | 0 | 35 | 2 |
| Selangor II | 2020 | Malaysia Premier League | 4 | 0 | – | – | – | – | – | – | 4 | 0 |
| Selangor II | Total | Total | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 |
| Selangor | 2020 | Malaysia Super League | 1 | 0 | 0 | 0 | 0 | 0 | – | – | 1 | 0 |
| Selangor | Total | Total | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Sarawak United | 2021 | Malaysia Premier League | 17 | 0 | – | – | 7 | 0 | – | – | 24 | 0 |
| Sarawak United | Total | Total | 17 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 24 | 0 |
| Selangor | 2022 | Malaysia Super League | 5 | 0 | 1 | 0 | 0 | 0 | – | – | 6 | 0 |
| Selangor | Total | Total | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 | 0 |
| Penang (loan) | 2023 | Malaysia Super League | 12 | 0 | 2 | 0 | 0 | 0 | – | – | 14 | 0 |
| Penang (loan) | Total | Total | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 14 | 0 |
| Kuala Lumpur Rovers | 2024–25 | Malaysia A1 Semi-Pro League | 2 | 0 | 1 | 0 | 0 | 0 | – | – | 3 | 0 |
| Career total | Career total | Career total | 63 | 1 | 9 | 0 | 15 | 1 | 0 | 0 | 87 | 2 |
* ↑ Appearances in Malaysia FA Cup
* ↑ Appearances in Malaysia Cup

## Honours
### Club
#### Felda United

* Malaysia Premier League : 2018

### International

Malaysia U-19
* AFF U-19 Youth Championship: 2018, runner-up: 2017
# Noor Hazrul Mustafa

Mohd Noor Hazrul bin Mohd Mustafa (born 11 October 1988 in Perak) is a Malaysian professional footballer. Currently he plays for BRM FC. He started his career as a defender, but is mostly used as a midfielder.

## Career

He started his football career with his home state team, Perak FA. He represented Perak for the 2006 Sukma Games in Kedah. He was also part of the Malaysia team that gave a good account of themselves in the Champions Youth Cup 2007 tournament, which was held in Kuala Lumpur. He was promoted to the senior Perak FA team for the 2008 season.
Noor Hazrul made his first team debut on 18 November 2007, coming on as a substitute in a match against DPMM FC. He made his first start against UPB-MyTeam FC on 21 November 2007. He scored his first ever senior goal on 12 January 2008 against title rivals Kedah FA. However, Perak FA lost that match 2–5. After four years playing for Perak FA, he decided to join the east coast side, Kelantan FA and quickly gained the attention of The Red Warriors fan after scoring a goal in his debut for the team.

## Career statistics
### Club

    As of 10 July 2018
| Club performance | Club performance | League | League | Cup | Cup | League Cup | League Cup | Continental | Continental | Total | Total |
| Season | Club | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| 2009 | Perak | 13 | 2 | | | | | – | – | | |
| Total | Total | 13 | 2 | | | | | | | | |
| 2010 | Perlis | 9 | 4 | | | | | – | – | | |
| Total | Total | 9 | 4 | | | | | | | | |
| 2011 | Perak | 22 | 3 | | | | | – | – | | |
| 2012 | Perak | 10 | 0 | - | - | - | - | - | - | | |
| 2013 | Perak | 0 | 1 | - | - | - | - | - | - | | |
| 2014 | Perak | 0 | 0 | - | - | - | - | - | - | | |
| Total | Total | | 4 | | | | | – | – | | |
| 2015 | Kelantan | 11 | 2 | 3 | 0 | 4 | 0 | – | – | 18 | 2 |
| 2016 | Kelantan | 10 | 0 | 1 | 0 | 2 | 0 | – | – | 13 | 0 |
| Total | Total | 21 | 2 | 4 | 0 | 6 | 0 | – | – | 31 | 2 |
| 2017 | Negeri Sembilan | 17 | 0 | 5 | 0 | 3 | 0 | – | – | 25 | 0 |
| 2018 | Negeri Sembilan | 9 | 0 | 1 | 0 | 0 | 0 | – | – | 10 | 0 |
| Total | Total | 26 | 0 | 6 | 0 | 3 | 0 | – | – | 35 | 0 |
| Career Total | Career Total | | | | | | | – | – | | |
# Annil Vigneswaran

Annil Vigneswaran (born 25 August 2003) is a Malaysian professional footballer who plays as a defender for Thai League 1 club Ratchaburi.

## Club career
### Early life

Born in Kajang, Selangor, Vigneswaran first took an interest in football at the age of seven, with his father enrolling him in a Little League side, for players aged 5–16 across the Klang Valley. At the age of ten, he spent one year with Dutch side Ajax, before returning to Malaysia to join the Kuala Lumpur Youth Soccer (KLYS) team.

### Move to Germany

At the age of fourteen, he was scouted by German side SGV Freiberg, and eventually moved to Germany to join the club. In February 2022, he joined 2. Bundesliga side Sandhausen.
For the 2022–23 season, he joined Oberliga Baden-Württemberg side Freiburger FC, but was assigned to the club's second team in the Landesliga Südbaden 2.

## International career

In October 2021, he received a surprise call up to the Malaysia national under-23 football team, having not attended any of the training camps in Malaysia. This call up was criticised by fans, with then-coach Brad Maloney coming to Vigneswaran's defence, saying "assistant coach, Khan Hung Meng used to train this player before he went to Germany a few years ago and he was seen as a very talented player and since then, his performance has started to be monitored."
# Clark Davis (wrestler)

Clark Davis (born 15 May 1957 in Calgary) is a Canadian former wrestler who competed in the 1984 Summer Olympics and in the 1988 Summer Olympics.
# Budden Memorial Church (Almora)

The Budden Memorial Church is a Methodist church located in Dharanaula, Almora, Uttarakhand, India.

## Description

Built in 1897, the church was constructed in memory of John Henry Budden, a British missionary associated with the London Missionary Society, who served in the Kumaon region from 1862 until his death in 1890. The foundation stone of the church was laid on 2 March 1897. The church is built in the Romanesque architectural style, featuring a notable large 18th-century clock. The Church is approximately 30 meters in height and 40 meters in length.
# So Fresh, So Clean

"So Fresh, So Clean" is a song by American hip hop duo Outkast from their fourth studio album, Stankonia (2000), featuring uncredited vocals from singer-songwriter Sleepy Brown. It was produced by longtime collaborators Organized Noize. The song reached number 30 on the US Billboard Hot 100 chart and was certified platinum by the Recording Industry Association of America (RIAA) in October 2020.

## Content

Among the things and people mentioned in the song are the Chevrolet Monte Carlo and Cadillac Eldorado (both General Motors cars), the television show Showtime at the Apollo and its longtime host Kiki Shepard, and R&B singers Teddy Pendergrass and Freddie Jackson.

## Sample

The song prominently features a sample from Joe Simon's "Before the Night Is Over". The song also features a sample from Funkadelic's "I'll Stay".

## Chart performance

"So Fresh, So Clean" debuted at number 71 on the US Billboard Hot 100 chart dated March 3, 2001. The song eventually reached it peak at number 30 on the chart dated May 5, 2001. On October 8, 2020, the single was certified platinum by the Recording Industry Association of America (RIAA) for combined sales and streaming equivalent units of over a million units in the United States.

## Music video

The music video features the duo and Sleepy Brown performing on a variety of CGI backgrounds, a beauty parlor, and a church. Ludacris, Slimm Calhoun, Chilli of TLC and members of Goodie Mob make cameo appearances in the video.

## Remix

The official remix, "So Fresh, So Clean (Stankonia Remix)" features Snoop Dogg and Sleepy Brown. It appeared on the soundtrack of Snoop Dogg's movie Bones under the name "Fresh and Clean (Remix)".

## Certifications

| Region | Certification | Certified units/sales |
| Australia (ARIA) | Gold | 35,000$^‡$ |
| United Kingdom (BPI) | Silver | 200,000$^‡$ |
| United States (RIAA) | 2× Platinum | 2,000,000$^‡$ |
| $^‡$ Sales+streaming figures based on certification alone. |||

## Release history

| Region | Date | Format(s) | Label(s) |
| United States | March 13, 2001 | 12-inch vinyl | LaFaceArista |
| Australia | May 28, 2001 | CD | LaFaceArista |
| Sweden | May 28, 2001 | CD | LaFaceArista |
| United Kingdom | May 28, 2001 | 12-inch vinylCDcassette | LaFaceArista |

## Use in media

The song was featured in the 2002 movie The New Guy.
In 2017, the song appeared in the first episode of Marvel's Iron Fist. Also in 2017, it appeared on the soundtrack for the video game NBA 2K18.
The song also appears in the jukebox musical Moulin Rouge! as part of the opening medley "Welcome to the Moulin Rouge!". The song is sung by the musical's primary antagonist, the Duke of Monroth, and serves as his introductory song.
# Afiq Saluddin

Afiq bin Saluddin (born 21 June 1998) is a Malaysian professional footballer who last played for Malaysia Premier League side Kelantan as a forward.

## Career statistics
### Club

    As of match played 17 February 2019
Appearances and goals by club, season and competition :
| Club | Season | League | League | League | Cup | Cup | League Cup | League Cup | Continental | Continental | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| Kelantan | 2018 | Malaysia Super League | 5 | 0 | 0 | 0 | 0 | 0 | – | – | 5 | 0 |
| Kelantan | 2019 | Malaysia Premier League | 4 | 0 | 0 | 0 | 0 | 0 | – | – | 4 | 0 |
| Kelantan | Total | Total | 6 | 0 | 0 | 0 | 0 | 0 | – | – | 6 | 0 |
| Career Total | Career Total | Career Total | 9 | 0 | 0 | 0 | 0 | 0 | – | – | 9 | 0 |
# Sabine Devooght

Sabine Devooght (born 24 April 1986) is a Belgian female badminton player.

## Achievements
### BWF International Challenge/Series

Mixed Doubles
| Year | Tournament | Partner | Opponent | Score | Result |
| 2013 | Cyprus International | Nathan Vervaeke | Oliver Gwilt Sarah Thomas | 10-21, 17-21 | Runner-up |
    BWF International Challenge tournament
    BWF International Series tournament
    BWF Future Series tournament
# Jai Bhadra Singh

Jai Bhadra Singh is an Indian politician. He was elected to the Lok Sabha, the lower house of the Parliament of India from the Sultanpur, Uttar Pradesh as a member of the Bahujan Samaj Party.
# Balthis House

Balthis House, also known as E.C. Balthis Blacksmith Shop Property and Balthis' Old Stand, is a historic home located at Front Royal, Warren County, Virginia. The original section was built about 1787, and is a two-story, five-bay, timber-frame vernacular Federal style dwelling. The original section is three bay. The house was expanded to its present size in the mid-19th century, at the same time as the addition of the two-story brick rear ell. Also on the property are the contributing kitchen dependency and playhouse / gazebo.
The house is now owned by the Warren Heritage Society and is open for tours.
The house was listed on the National Register of Historic Places in 2004. It is located in the Front Royal Historic District.
# Mount Wonvara

Mount Wonvara or Wonvagre (Hiw: Wōnvar̄e) is the highest point of Hiw, the northernmost island of Vanuatu. It has an elevation of 366 metres (1,201 ft).
# Frank Figliuzzi

Cesare Frank Figliuzzi, Jr. (born September 12, 1962) is an American former law enforcement agent and author, who served as assistant director for counterintelligence at the Federal Bureau of Investigation. Figliuzzi was previously the special agent in charge of the Federal Bureau of Investigation's Cleveland Division, which includes all of northern Ohio, and the major cities of Cleveland, Toledo, Youngstown, Akron, and Canton.
Following his FBI service, Figliuzzi joined General Electric and served for five years as assistant chief security officer for investigations, insider threat, workplace violence prevention, and special event security for GE's 300,000 employees in 180 countries. Figliuzzi is a Senior National Security and Intelligence Analyst for NBC and MSNBC News.

## Education

Figliuzzi earned a Bachelor of Arts degree in English literature from Fairfield University and a Juris Doctor with honors from the University of Connecticut School of Law. Figliuzzi also completed the Harvard University National Security Program for Senior Executives in Government at the John F. Kennedy School of Government.

## Career

Figliuzzi joined the FBI as a special agent in August 1987 and has worked for the FBI in the Atlanta and Washington, D.C., headquarters, and the San Francisco, Miami, and Cleveland offices. He was the assistant special agent in charge of the Miami Field Office, the FBI's fifth largest office. Figliuzzi also served as the FBI's chief inspector from December 2005 until his appointment as head of the Cleveland Division. As Assistant Director, he was based at FBI Headquarters in Washington, D.C., and worked closely with other government executives.
In February 2011 then-director Robert Mueller appointed Figliuzzi assistant director of the FBI's Counterintelligence Division.

## Author

Figliuzzi is the author of two nonfiction books, The FBI Way: Inside the Bureau's Code of Excellence, published in 2021, and Long Haul: Hunting the Highway Serial Killers, published in 2024.
# Conus diminutus

Conus diminutus is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.
Like all species within the genus Conus, these snails are predatory and venomous. They are capable of stinging humans, therefore live ones should be handled carefully or not at all.

## Description

The size of the shell varies between 9 mm and 22 mm.

## Distribution

This species occurs in the Atlantic Ocean along the west coast of the island Boa Vista, Cape Verde and Senegal.
# Mos Speedrun

Mos Speedrun is an 8-bit retro-style game by British developer Physmo, released in April 2011 for iOS, October 2011 for PC, and January 2012 for Android.
Gameplay revolves around clearing levels and collecting coins as quickly as possible but forgoes the virtual d-pad typically used by iOS platformers in favor of a simplified two button control system.
Physmo later came out with a sequel, named Mos Speedrun 2.