# Wladimir Wertelecki

Wladimir Wertelecki :
| Born | (1936) In Rivne, Volyn, Ukraine (at the time Poland) |
| Residence | USA |
| Fields | Clinical Teratology, Genetics and Pediatrics |
| Postgraduate | Intern, Muniz Hospital, Buenos Aires, Argentina (1961 - 1962). Intern, Deaconess Hospital, St. Louis, MO, U.S. (1963). Resident in Pediatrics, St. Louis Children's Hospital and Washington University Medical School, St. Louis, MO (1964 - 1966). Fellow in Clinical Genetics, Boston Children's Hospital and Harvard Medical School, Boston, MA (1966 - 1968) |
| Institutions | Instructor, Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA (1968–1969). Senior Surgeon, U.S. Public Health Commissioned Corps., Epidemiology Branch, National Cancer Institute, Bethesda, MD (1969–1972). Assistant Professor, Pediatrics, Medical University of South Carolina, Charleston, SC (1972). Associate Professor, Pediatrics and Pathology, Medical University of South Carolina, Charleston, SC (1973–1974). Professor and chairman, Department of Medical Genetics, University of South Alabama, Mobile, AL (1974–2010). Professor Emeritus, University of South Alabama, Mobile, AL (2010-). Director, OMNI-Net Ukraine, Birth Defects Monitoring Programs (1999-) |
| Alma mater | Medical School, University of Buenos Aires, Argentina (1956–1961) |
| Mentors | Taras Mykysha, Volodymyr Lasovskyi, Bernardo Houssay, Niсeto S. Loizaga, M.D., Alexis Hartmann, Harold Cummins, PhD., Josef Warkany, Daniel C. Gajdusek, John Gofman |
| Currently known for | Population-based monitoring of developmental anomalies in Chornobyl-impacted regions |
| Notable awards | Corresponding Member of the "Academia Nacional de Medicina" (Buenos Aires, Argentina) and Foreign Member of the National Academy of Sciences (Kyiv, Ukraine), Doctor Honoris Causa, National University of Kyiv-Mohyla Academy (Kyiv, Ukraine) and Lviv Medical University (Lviv, Ukraine) |
Wladimir Wertelecki is a pediatrician and medical geneticist. In 1974, he established one of the first free-standing Departments of Medical Genetics at the new South Alabama University College of Medicine in Mobile, Alabama, U.S.A. Following his retirement as chairman and emeritus Professor of Medical Genetics, Pediatrics, and Pathology, he continued his investigations into the prevention of developmental anomalies as a Project Scientist at the Department of Pediatrics, University of California San Diego. Since 1996, his research has focused mainly on alcohol and the impact of ionizing radiation on congenital anomalies. He is the author over 135 scientific reports.
He established a regional network of clinics across southern Alabama and West Florida, and in 1978 he organized the Southern Genetic Group. This group expanded into the South-Eastern Regional Genetics Group, which enhanced genetic services in six states. Wertelecki also helped local Native-Americans gain Federal Recognition in Alabama.
In 1992, he made a presentation to the US Senate regarding the reproductive risks posed by Chornobyl radiation. In 2000, following an initial sponsorship by USAID, he established the OMNI-Net program, a not-for-profit network, to investigate the reproductive risks posed by exposure to alcohol and ionizing radiation from Chornobyl. The program trained Ukrainian professionals to monitor the frequency of birth defects.

## Career

Wertelecki began his medical education in 1955 at the School of Medicine of the University of Buenos Aires. As a medical student, he took additional courses to qualify as a teaching assistant in human anatomy (1957) and in physiology (1958).
These extracurricular courses proved to be formative. In anatomy, he observed an instance of anatomic atavism ("maneus muscle") which stimulated his interest in anatomical variants, anomalies, and evolution. His interest in physiology enabled him to join a research team headed by Dr. Virgilio G. Foglia, an expert in the experimental production of diabetes in rats. This team, coordinated by Dr. Bernardo Houssay, a Nobel Prize winner, was dedicated to defining factors which regulated blood sugar, pre-diabetes, diabetes, and their impacts on embryonic development.
Wertelecki's first scientific reports concerned reproductive impacts and birth weights. As a student of clinical medicine, Wertelecki was granted a university scholarship and became an assistant to Dr. Niceto S. Loizaga, an expert in semiology (skills to recognize signs as signals of syndromes and diagnoses) (1958–1961). Wertelecki's task, among others, was the coordination of a clinic caring for patients with Down syndrome, then referred to as "Mongolism". This experience added to his interest in genetics and birth defects, which prompted him to seek further training in the United States (1991).
After completing a rotating internship (1962–1963), he became a pediatric resident (1963–1965) at the Department of Pediatrics, St. Louis Children's Hospital and Washington University headed by Dr. Alexis F. Hartmann, one of the first to use insulin to treat diabetic children. During his residency, his semiology skills led to his first scientific report in the U.S. - recognition of cantharidin poisoning of children. Wertelecki's sought further training in Clinical Genetics as a fellow at the Boston Children's Hospital and Harvard Medical School (1965–1968). His tasks included participation in the Phenylketonuria Treatment clinic and the development of computer-aided programs to gather family reproductive histories.
His publications include the recognition and significance of partial loss of a segment of chromosome 18 (contradicting the presumption that such events are lethal). Another report concerned computer-aided role of gathering family reproductive histories. During 1968–1970, Wertelecki studied clinical epidemiology while serving as a Senior Surgeon (Commander) of the US Public Health Corp at the Epidemiology Branch of the National Cancer Institute) and consultant in Medical Genetics at the Naval National Medical Center in Bethesda, Maryland. Having access to computerized medical records and to the National Institutes of Health Clinics, he demonstrated that therapies prescribed to epileptic women had children with a higher frequency of facial clefts and that leukemia was unduly heavier at birth.
He also analyzed the fingertip ridged skin patterns of leukemic children. The complexities of these investigations and analyses, led Wertelecki to incorporate perspectives of distinguished advisors and collaborators, including Mr. Nathan Mantel—after whom a statistical test is named— and Dr. Robert W. Miller—who defined provocative associations of particular birth defects with particular cancers. Regarding dermal ridges, Wertelecki formed a life-long partnership with Dr. C.C. Plato, a pioneer of Dermatoglyphics, a discipline dedicated to the study of dermal (volar skin) ridges. The cited investigations also led Wertelecki toward another life-long association with Dr. Josef Warkany, considered the main pioneer and founder of the Teratology Society dedicated to studying birth defects.
In 1971, Wertelecki became an assistant professor, and in 1972 an associate professor of Pediatrics and Pathology at the Medical University of South Carolina. A report of the characteristics of Triploid syndrome reflects his interest in Semiology and medical students - the medical student co-author is a recognized authority in Medical Genetics (JG). In 1974, Wertelecki joined the University of South Alabama Medical University, a newly established institution. His main task was establishing a free-standing Department of Medical Genetics, arguably among the country's first. He recruited as Distinguished Visiting Professors, Drs. J. Warkany and H. Zellweger, both recognized as world leaders of pediatrics and advocates of preventive public health policies.
In 1978, Wertelecki was the prime organizer of the Southeastern Regional Genetics Group (SERG) dedicated to coordinating regional resources and clinical services along with initiatives to promote computer-driven data collection of genetic services. His department became an accredited site for training physicians in Clinical Genetics and Clinical Cytogenetics. In addition to U.S. graduates, international trainees included those from Japan, Argentina, Brazil, Sri Lanka, China, India, among others.
In 1986, the impact of the Chornobyl disaster on Wertelecki was considerable. He noted that during the International Congress of Human Genetics of 1986 and 1991, the attention to potential Chornobyl ionizing radiation impacts on human embryos was modest. In 1992, Wertelecki was invited to address a U.S. Senate Committee regarding Chernobyl and child health. In 1996, he received a small grant from Child Health to organize a Symposium during the Human Genetics International Congress of 1996 on the subject of Chornobyl radiation impacts on child development. The participating International experts, including those from Belarus and Ukraine, defined areas of concern and potential investigations. Wertelecki sought further advice from John William Gofman (Professor Emeritus of Molecular and Cell Biology at University of California at Berkeley), Daniel Carleton Gajdusek (Pediatrician winner of the Nobel Prize for the discovery of the human prion disease), Jennifer L Howse (President of the March of Dimes Foundation), Mike Katz (vice-president for Science, March of Dimes Foundation), Godfrey Oakley (Director of the Division of Birth Defects of the U.S. Centers for Disease Control and Prevention), among others.
In 1999, a plan to establish a population based monitoring of birth defects upholding international standards in several regions of Ukraine was submitted and approved by the Ukrainian Ministry of Health, Wertelecki accepted to be the director of the project now referred to as OMNI-Net Ukraine Programs. In 2000, with initial support from the USAID, population surveillance of birth defects monitoring was initiated. In 2002, OMNI-Net data documented a high frequency of spina bifida, which persists to the present. Since then, OMNI-Net members advocate for the introduction of mandatory fortification of flour with folic acid to reduce spina bifida and related disorders by at least 50%.
In 2006, OMNI-Net qualified for full membership of the European birth defects monitoring network (EUROCAT) and became a participant in the Collaborative Initiative of Fetal Alcohol Spectrum Consortium (CIFASD) In 2021, OMNI-Net restarted a Spina Bifida – Hydrocephalus prevention initiative by petitions to the President and Prime Minister to introduce folic acid mandatory fortification of flour in Ukraine. This narrative is further illustrated by an annotated bibliography of peer-reviewed scientific reports and other creative publications by Wertelecki and OMNI-Net members, which by May 2021 approach 190 in number.

## Honors and awards

Amond others:
* 1988 SERGG South-Eastern Regional Genetics Group (Recognition).
* 1989 Humanitarian Award, Mobile Association for Retarded Citizens.
* 1992 Foreign Corresponding Member of Academy of Medicine, Buenos Aires, Argentina.
* 1998 Honorary Professor, Kharkov State University, School of Medicine.
* 1998 Distinguished Service Award, American Dermatoglyphics Association.
* 1999 Franklin Smith Award for Distinguished Service, State of Alabama.
* 2003 Foreign Member of the National Academy of Sciences, Ukraine.
* 2003 Doctor Honoris Causa, National University of Kyiv-Mohyla Academy, Ukraine.
* 2010 Doctor Honoris Causa, Lviv Medical University, Ukraine.
* 2016 Distinguished Service Award by the University of South Alabama Medical Alumni Association.

## Organizations

Among others, past and current:
* American College of Medical Genetics and Genomics
* American Society of Pediatrics and Pediatric Research (Emeritus)
* American Academy of Pediatrics
* The Teratology Society
* Academia Nacional de Medicina (Argentina)
* National Academy of Sciences of Ukraine
* American Public Health Association

## Selected scientific publications

(among others, for complete bibliography please see PubMed)

### Selected early publications

* Foglia, V.G., Fernandez-Collazo, E.L., Wesley, O.R., Wertelecki, W., Granillo, R.: Trastornos de la Reproduccion de La Rata Macho Diabetica. Rev. Soc. Argent. Biol. 37:127 (1961).
* Wertelecki, W; Schindler, A.M; Gerald, P.S (1966). "Partial Deletion of Chromosome 18". The Lancet. 288 (7464): 641. doi:10.1016/S0140-6736(66)91964-7.
* Kennedy Jr, J. L; Wertelecki, W; Gates, L; Sperry, B. P; Cass, V. M (1967). "The early treatment of phenylketonuria". American Journal of Diseases of Children. 113 (1): 16–21. doi:10.1001/archpedi.1967.02090160066004. PMID 6016173.
* Wertelecki, W., Lawton, T.J.: A Computer Program for Gathering Family History. Eighth IBM Medical Symposium, p. 165 (1967).
* Wertelecki, W; Mantel, N (1973). "Increased Birth Weight in Leukemia". Pediatric Research. 7 (3): 132–8. doi:10.1203/00006450-197303000-00005. PMID 4511339.
* Niswander, J. D; Wertelecki, W (1973). "Congenital malformation among offspring of epileptic women". Lancet. 1 (7811): 1062. doi:10.1016/s0140-6736(73)90699-5. PMID 4122140.
* Wertelecki, W; Graham Jr, J. M; Sergovich, F. R (1976). "The clinical syndrome of triploidy". Obstetrics and Gynecology. 47 (1): 69–76. PMID 1246396.
* Wertelecki, W; Superneau, D. W; Blackburn, W. R; Varakis, J. N (1982). "Neurofibromatosis, skin hemangiomas, and arterial disease". Birth Defects Original Article Series. 18 (3B): 29–41. PMID 6814548.
* Wertelecki, Wladimir; Rouleau, Guy A; Superneau, Duane W; Forehand, Lois W; Williams, John P; Haines, Jonathan L; Gusella, James F (1988). "Neurofibromatosis 2: Clinical and DNA Linkage Studies of a Large Kindred". New England Journal of Medicine. 319 (5): 278–83. doi:10.1056/NEJM198808043190505. PMID 3134615.
* Wertelecki, Wladimir; Smith, Lynne T; Byers, Peter (1992). "Initial observations of human dermatosparaxis: Ehlers-Danlos syndrome type VIIC". The Journal of Pediatrics. 121 (4): 558–64. doi:10.1016/S0022-3476(05)81144-8. PMID 1403389.

### Most recent publications

* Bandoli G, Coles CD, Kable JA, Wertelecki W, Yevtushok L, Zymak-Zakutnya N, Wells A, Granovska IV, Pashtepa AO, Chambers CD; CIFASD. Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development. Pediatrics. 2019 Feb;143(2). pii: e20182399. doi:10.1542/peds.2018-2399 Epub 2019 Jan 4. PubMed PMID 30610099; PubMed Central PMCID: PMC6361345.
* Sarkar DK, Gangisetty O, Wozniak JR, Eckerle JK, Georgieff MK, Foroud TM, Wetherill L, Wertelecki W, Chambers CD, Riley E, Zymak-Zakutnya N, Yevtushok L. Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. Alcohol Clin Exp Res. 2019 Sep;43(9):1887-1897. doi:10.1111/acer.14148 Epub 2019 Aug 6. PubMed PMID 31329297; PubMed Central PMCID: PMC6722014.
* Bakker MK, Kancherla V, Canfield MA, Bermejo-Sanchez E, Cragan JD, Dastgiri S, De Walle HEK, Feldkamp ML, Groisman B, Gatt M, Hurtado-Villa P, Kallen K, Landau D, Lelong N, Lopez Camelo JS, Martínez L, Morgan M, Mutchinick OM, Nembhard WN, Pierini A, Rissmann A, Sipek A, Szabova E, Tagliabue G, Wertelecki W, Zarante I, Mastroiacovo P. Analysis of Mortality among Neonates and Children with Spina Bifida: An International Registry-Based Study, 2001–2012. Paediatr Perinat Epidemiol. 2019 Nov;33(6):436-448. doi:10.1111/ppe.12589 Epub 2019 Oct 21. PubMed PMID 31637749.
* Wertelecki W. Josef Warkany's gestation of the teratology society. Birth Defects Res. 2020 Jul 15;112(12):885-889. doi:10.1002/bdr2.1684 PMID 32686352.
* Bandoli G, Jones K, Wertelecki W, Yevtushok L, Zymak-Zakutnya N, Granovska I, Plotka L, Chambers C; CIFASD. Patterns of Prenatal Alcohol Exposure and Alcohol-Related Dysmorphic Features. Alcohol Clin Exp Res. 2020 Oct;44(10):2045-2052. doi:10.1111/acer.14430 Epub 2020 Sep 6. PMID 32772389; PMCID: PMC7722075.
* Kable JA, Coles CD, Jones KL, Yevtushok L, Kulikovsky Y, Zymak-Zakutnya N, Dubchak I, Akhmedzhanova D, Wertelecki W, Chambers CD; CIFASD. Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period. Alcohol Clin Exp Res. 2021 Feb;45(2):386-394. doi:10.1111/acer.14525 Epub 2021 Jan 6. PMID 33277942; PMCID: PMC7887046.
* Wertelecki W. Chornobyl radiation-congenital anomalies: A persisting dilemma. Congenit Anom (Kyoto). 2021 Jan;61(1):9-13. doi:10.1111/cga.12388 Epub 2020 Aug 19. PMID 33405251.
* Patskun E, Yevtushok L, Zymak-Zakutnia N, Lapchenko S, Akhmedzhanova D, Wertelecki W. A teratology information system in vernacular: Closing an information gap. Birth Defects Res. 2021 Apr 24. doi:10.1002/bdr2.1901 Epub ahead of print. PMID 33893758.
* Coles CD, Kable JA, Granovska IV, Pashtepa AO, Wertelecki W, Chambers CD; CIFASD. Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children. Child Neuropsychol. 2021 May 13:1-16. doi:10.1080/09297049.2021.1919298 Epub ahead of print. PMID 33982636.

### Books, chapters and other publications (partial list)

* Wertelecki, W., Lawton, T., Gerald, P.S.: Computer-Based Patient Interviewing. In: Computer-Assisted Instruction in the Health Professions. Eds., Stolurow, L.M., Peterson, T.I., Cunningham, A.C., Entelek, Inc., Newburyport, MA (1970).
* Wertelecki, W., Peterson, R.D.A.: Primary Immunodeficiency Syndromes. In: Surgical Immunology. Ed., Munster, A.M., Grune Publishers, New York, NY (1976).
* Wertelecki, W.: Regional Rural Genetics Program: Educational Considerations. In: The Management of Genetic Disorders. Eds., Bartsocas, C.S., Papadatos, C., Alan R. Liss Publishers, New York, NY (1979).
* Wertelecki, W., Plato, C., Editors: Dermatoglyphics – 50 Years Later. (Birth Defects Original Article Series Vol. XV, No. 6). Alan R. Liss Publishers, New York, NY (1979).
* Wertelecki, W.: Tetraploidy. In: Handbook of Clinical Neurology, Neurogenetic Directory. Ed., Myrianthopoulas, N.C., Part II, North-Holland Publishing Co., Amsterdam (1982).
* Castilla, E., Penchaszadeh, V., Wertelecki, W., Youlton, R.: Prevention and Control of Genetic Diseases and Congenital Defects: Report of an Advisory Group. Pan American Health Organization/World Health Organization, 525 Twenty-Third Street, Washington, D.C., Scientific Publication No. 460 (1984).
* Wertelecki, W.: Roberts Syndrome. Birth Defects Encyclopedia, 3rd Edition, Buyse, M.L., Editor. Blackwell/Year Book Medical Publishers, Inc. pp. 1498-1499 (1990).
* Wertelecki, W.: Chromosome 22. Birth Defects Encyclopedia, 3rd Edition, Buyse, M.L., Editor. Blackwell/Year Book Medical Publishers, Inc. pp. 395 (1990).
* Wertelecki, W.: A Regional Genetics Program in Alabama with Emphasis on Education and Clinicians - Achievements and Experience. In: Medical Genetics and Society. Eds., Fujiki, N., Bulyzhenkov, V., Bankowski, Z., Kugler Publications, Amsterdam/New York, (1991).
* Wertelecki, W.: Diagnosis of NF-2. In: Neurofibromatosis 2. Eds., Cohen, B.R. Korf, B.H., Pugh, J.N., The National Neurofibromatosis Foundation, Inc., New York, NY (1992).
* Wertelecki, W.: Clinical Dermatoglyphics. In: Human Malformations and Related Anomalies, Eds., Stevenson, R.E., Editor. Oxford University Press, Inc. (1993).
* Wertelecki W.: Congenital Malformations in Rivne, Ukraine. 119–138. In: Crisis Without End: The Medical and Ecological Consequences of the Fukushima Nuclear Catastrophe. Helen Caldicott, editor. New Press, The, Oct 21, 304 pages (2014).
Further listing omitted.

## Current special projects

Among others:
* Mandatory Folic Acid Flour Fortification in Ukraine
* Prevention and Care of Spina Bifida and Related Disorders
* Adolescence and Adult Developmental Patterns of Children with Fetal Alcohol Spectrum Disorders
* Analyses of Cs-137 Incorporated Levels Trends
* Distant Learning Modules
** Parents and Public
** Medical Students
** Health Care Providers
* Sustenance of Contents in Dedicated Websites
** Medications and the Unborn
** Clinical Signs – Eye Openers
** Medical Terminology and Humanities
** I.B.I.S. – International Birth Defects Information System (in short)
** OMNI-Net Ukraine