OpenLLM-France/wikimedia huggingface dataset:
# Hypoxia-activated prodrug

Hypoxia-activated prodrugs are prodrugs that target regions of tumor hypoxia within tumor cells. These types of drugs have the potential, alone and in combination with conventional chemotherapy, of improving cancer therapy. It is believed that tumor hypoxia contributes significantly to treatment failure and relapse among cancer patients because cells in the hypoxic zones of solid tumors resist traditional chemotherapy for at least two reasons: first, most antitumor agents cannot penetrate beyond 50-100 micrometers from capillaries, thereby never reaching those cells in the hypoxic regions. Secondly, the lower nutrient and oxygen supply to cells in the hypoxic zones of tumors cause them to divide more slowly than their well oxygenated counterparts, so hypoxic tumor cells exhibit greater resistance to chemotherapies and radiation which target rapidly dividing cells or require oxygen for efficacy.
Hypoxia also contributes to the invasive and metastatic phenotypes of aggressive cancers by promoting genetic instability and accelerating the accumulation of mutations that can ultimately give rise to drug resistance.

## Companies working on hypoxia-activated prodrugs

Several companies worked on developing hypoxia-activated prodrugs.
Defunct or not actively working on HAPs anymore:
* Novacea, Inc. (acquired by Transcept/Paratek pharmaceuticals),
* Proacta Inc. (now defunct)
* Threshold Pharmaceuticals, Inc (merged with Molecular Templates, which was delisted end 2024)
Actively working on it:
* Convert Pharmaceuticals
These companies were/are involved in developing the following drug candidates: AQ4N (Novacea), PR-104 (Proacta) and TH-302 (evofosfamide), CP506 and TH-4000/tarloxotinib (Convert Pharmaceuticals).
# Frode Lafton

Frode Lafton (born 3 March 1976) is a Norwegian former footballer who played as a defender for Hønefoss throughout his career. He was also the club's captain. On 9 May 2013 he retired from football cause a knee injury he not recovered from. On 17 August 2016 he took over Hønefoss as manager.
# Bogdan (bus model)

Bogdan (Ukrainian: Богдан, romanized: Bohdan) is the brand of the Ukrainian buses and trolleybuses made by Bogdan Corporation. The original two front-engine/rear-wheel drive models (Bohdan A091 and Bohdan A092) are powered by Isuzu and marketed outside Ukraine under Isuzu brand. Large city buses, such as the rear-engined Bogdan A145 and Bohdan A1445, are also produced. The production is situated in the city of Cherkasy, although there are plans of moving it to the LuAZ plant in the city of Lutsk. These vehicles are generally serving as marshrutka (routed taxicab / minibus) in former Soviet regions. The plant was originally the Cherkasy Autorepair Plant, which was founded in 1964.

## Serial production models
### Small class minibuses

* Bogdan A064 (2003–2005) – based on Isuzu
* Bogdan A067 (2005–2006) – based on Foton
* Bogdan A069 (2006–2013) – based on Hyundai
* Bogdan A049 (2010–2011) – based on GAZ
* Bogdan A067 in Kyiv
* Bogdan A069 in Kherson

### Medium class minibuses

* Bogdan A091 (1999–2005) – based on Isuzu
* Bogdan A092 (2003–2011) – based on Isuzu
* Bogdan A201 (2011–2021) – based on Hyundai
* Bogdan A091 in Kyiv
* Bogdan A092 in Lviv
* Bogdan A201 in Tomsk

### Medium class intercity buses

* Bogdan A301 (2007–2010) – based on Isuzu

### Large class intercity buses

* Bogdan A145 (2003–2015) – based on Isuzu
* Bogdan A14542 (2016–2021)

### Large class city buses

* Bogdan A144 (2003–2011) – based on Isuzu
* Bogdan A601 (2008)
* Bogdan A701 (2011–2021)
* Bogdan A144 in Kyiv

### Medium class coaches

* Bogdan A401 (2007–2008) – based on Isuzu
* Bogdan A401 in Lviv

### Small class trolleybuses

* Bogdan T601 (2008–2011)
* Bogdan T601 in Lviv

### Large class trolleybuses

* Bogdan T701 (2010–2022)
* Bogdan T701 in Alushta

### Articulated trolleybuses

* Bogdan T901 (2012–2021)
* Bogdan T901 in Kyiv

## Prototype models
### Small class minibuses

* Bogdan A062 (2003) – based on Isuzu

### Small class city buses

* Bogdan A501 (2007) – based on Isuzu
* Bogdan A601 (2009) – based on Isuzu
* Bogdan A09280 (2010) – based on Isuzu
* Bogdan A302 (2011)
* Bogdan A601 in Lviv
* Bogdan A09280 in Lviv

### Extra large class buses

* Bogdan A231 (2004)
* Bogdan A801 (2010)
* Bogdan A801 in Lutsk

### Small class trolleybuses

* Bogdan T501 (2008)
* Bogdan T501 in Lutsk

### Extra large class trolleybuses

* Bogdan E231 (2007)
* Bogdan T801 (2011)
* Bogdan E231 in Lutsk
* Bogdan T801 in Kyiv

## Gallery

* Bogdan A092
* Bogdan A092 - Marshrutka in Sevastopol, Ukraine
* Bogdan A092.80 bus in Lviv, Ukraine
* Bogdan A144
* Bogdan A601.10 Lviv Premier
* Bogdan A601 interior
* Bogdan A601 interior
* BogdanT601 trolleybus in Simferopol, Crimea, Ukraine
* Bogdan T701.10
* Bogdan T701.15
# Priyant Singh

Priyant Kumar Singh (born 16 February 1991) is an Indian professional footballer who plays as a goalkeeper for Sudeva Delhi.

## Club career

After spending years in East Bengal youth system Priyant Singh moved to the senior team with his impressive performance. Later he went to Mohamedan Sporting, and gained experience before coming back to East Bengal in the year 2012. He has represented East Bengal U-19 NFL also during his stint with junior team. He made his debut in an AFC Cup match against Al Qadsia Kuwait, in which East Bengal lost 2–3.playing for Mankundu Sporting Club (In Chandannagar football league )
# Zarosliak

Zarosliak (Ukrainian: Навчально-спортивна база «Заросляк») is a high mountain sports training resort near town of Vorokhta (Yaremche city), Ukraine. It is located within the Carpathian National Nature Park at the foot of mount Hoverla. The resort is smaller than the nearly located Bukovel and more sports oriented.

## History

Since 1880 in place of a modern sports resort existed a tourist resort under the name "Heinrich Hoffbauer Tatra Polish Association". Heinrich Hoffbauer was known for creating the first tourist route over the Chornohora Ridge. During 1911-18 the resort suffered from fire and military conflicts of the World War I and was completely devastated. It was revived in 1923-27 and until the Soviet invasion was accepting 120-150 visitors a day. During the World War II it was destroyed once again and for some time became forgotten.
The modern resort traces its history from 1959. Since that time the resort was listed among the Olympic venues of the Ukrainian SSR and since 1991 - Ukraine. In 2004 here was built a 12-meter ski ramp for freestyle. Since a major renovations that took place in 2008, Zarosliak may accept up to 90 visitors a day.
# Quaternary (EP)

Professional ratings :
| Review scores ||
| Source | Rating |
| Collector's Guide to Heavy Metal | 6/10 |
Quaternary is an EP by the heavy metal band Mötley Crüe. It was released in 1994 on Elektra. The EP, which was initially going to be titled Leftovers, was made available as a mail-in offer for purchasers of the self-titled album in a limited quantity of 20,000 copies.

## Background

The EP features one song from each member of the band ("Planet Boom" by Tommy Lee, "Bittersuite" by Mick Mars, "Father" by Nikki Sixx, and "Friends" by John Corabi), along with the song "Babykills" which is performed by the entire band.
Songs 1–3 and 7 were reissued on the Supersonic and Demonic Relics compilation in 1999. Songs 1–2 were featured on the Red, White & Crüe compilation in 2005, and all the tracks were made available on the Music to Crash Your Car To: Vol. 2 box set in 2004.
The rap metal-influenced "Planet Boom" was later released on the soundtrack for Tommy Lee's then-wife Pamela Anderson's movie Barb Wire. However, the song was remade, credited to Tommy Lee only, and the title was changed to "Welcome to Planet Boom". A music video was also released for the song around the same time as the film's release.

## Credits

* John Corabi – lead vocals, rhythm guitar, piano, backing vocals
* Mick Mars – lead guitar, rhythm guitar, backing vocals
* Nikki Sixx – bass guitar, lead vocals on "Father", backing vocals
* Tommy Lee – drums, percussion, synthesizer, lead vocals on "Planet Boom", backing vocals
# Multia, Finland

Multia is a municipality of Finland. It is located in the Central Finland region. The municipality has a population of 1,391 (31 December 2024) and covers an area of 765.63 square kilometres (295.61 sq mi) of which 32.37 km$^2$ (12.50 sq mi) is water. The population density is 1.9 inhabitants per square kilometre (4.9/sq mi).
The municipality is unilingually Finnish. The municipality has previously also been known as "Muldia" in Swedish documents, but is today referred to as "Multia" also in Swedish.

## Geography

Neighbouring municipalities are Keuruu, Petäjävesi, Saarijärvi, Uurainen and Ähtäri. It is 60 kilometres (37 mi) from Multia to Jyväskylä, the capital city of Central Finland.
There are altogether 146 lakes in Multia. The biggest lakes in Multia are Sinervä, Tarhapäänjärvi and Sahrajärvi-Pienvesi.
The highest point of the Central Finland region, Kiiskilänmäki, which reaches an altitude of 269 metres (883 ft) above sea level, is located in Multia.
During the summer months (June - August), Multia is the rainiest municipality in Finland, with an average of 237.3 millimeters (9.3 inches) of rainfall.
Climate data for Multia Pirttiperä (1991-2020 normals) :
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Year |
| Average precipitation mm (inches) | 55 (2.2) | 43 (1.7) | 42 (1.7) | 39 (1.5) | 45 (1.8) | 73 (2.9) | 89 (3.5) | 79 (3.1) | 65 (2.6) | 73 (2.9) | 67 (2.6) | 65 (2.6) | 735 (28.9) |
| Average precipitation days (≥ 0.1 mm) | 21 | 18 | 16 | 12 | 13 | 15 | 15 | 15 | 15 | 19 | 21 | 23 | 203 |
| Source: https://www.ilmatieteenlaitos.fi/1991-2020-sadetilastot ||||||||||||||

## Events

Kicksled World Championship

## Notable people

* Seth Heikkilä (1863–1938)
* Tauno Sipilä (1921–2001)
* Pentti Papinaho (1926-1992)
* Erkki Pohjanheimo (born 1942)
# British Committee on the Theory of International Politics

The British Committee on the Theory of International Politics was a group of scholars created in 1959 under the chairmanship of the Cambridge historian Herbert Butterfield, with financial aid from the Rockefeller Foundation, that met periodically in Cambridge, Oxford, London and Brighton to discuss the principal problems and a range of aspects of the theory and history of international relations. The Committee developed a study of international society and the nature of world politics, which have had an important impact that continues in the present day.

## Meetings

Under the guidance of Herbert Butterfield, Martin Wight, Adam Watson and Hedley Bull, the British Committee on the Theory of International Politics met three times a year for an almost thirty-year period from the 1950s to the 1980s, once or twice in Italy. In 1974 a three days meeting (27-30 September) was held at Villa Serbelloni, Bellagio, in agreement with Rockefeller foundation.

## Publications

They produced books, essays, article, and they regularly wrote a series of papers specially conceived for the Committee which provoked lively internal discussions and most of which are still unpublished.

## Selected works

* Herbert Butterfield, Martin Wight (eds.), Diplomatic Investigations: Essays in the Theory of International Politics (London: Allen & Unwin, 1966).
* Hedley Bull, Adam Watson (eds.), The Expansion of International Society (Oxford: Clarendon Press, 1984).
* Martin Wight, Systems of States ed. Hedley Bull (Leicester: Leicester University Press, 1977).
# Mousecar

The Mousecar is an in-house award given by The Walt Disney Company for a variety of reasons, including service to the company as well as to the community as a whole. The award was first presented by Disney founder Walt Disney to his brother Roy O. Disney in 1947.
In 2005, Riley Thomson's Mousecar was auctioned for $5,358. In 2013 Bernie Cobb's Mousecar was auctioned for $8,531.

## Origin of the word

"Mousecar" is a combination of the words "Oscar" and "Mouse" (as in Mickey Mouse).

## List of recipients

* Louis Armstrong
* Bernie Cobb
* Marc Davis
* Roy O. Disney
* Bob Dorfman
* Jim Gardner
* Kathie Lee Gifford
* Manuel Gonzales
* Benny Goodman
* Floyd Gottfredson
* Winnie Grosso
* Dick Huemer
* Lucille Ogle
* Zack Schaja
* Sherman Brothers
* Robert Stevenson
* Riley Thomson
* Bob Weis Walt Disney Imagineering
* Elmo Williams
* Ed Wynn
* Heather Campbell
During the studio's 50th anniversary in 1973 special Mousecars were given to every employee who had worked at the original Disney Studio on Hyperion Street (1929-1939) in the Los Feliz section of Los Angeles, designating them members of the exclusive Hyperion Club.
# Metrication in Chile

Chile adopted the metric system in 1848. Previously, the Spanish system of measures was used.
Since colonization, Chile had always used a unit system based on the Spanish customary units. In 1843, a law was passed formalizing it, and defining its fundamental unit, the vara, as a fraction of a metre.
Later, during the presidency of Manuel Bulnes, a law was passed on 29 January 1848, adopting the Metric System. Finally, Chile signed the Metre Convention in 1908.

## Current exceptions

* Timber and pipes are sold in metres, but their width, thickness, and diameter are measured in inches.
* Nail mass is measured in grams, but length is measured in inches.
* Yarn is normally sold in yards.
* Tins of paint are usually sold in multiples of US gallons.
* Display sizes for the screens of televisions and computer monitors have their diagonals measured in inches.
* Tire pressure is measured in pounds per square inch.
* The most common paper size is letter (carta). A4 paper is rarely used.
* The price of copper, Chile's most exported material, is usually quoted in dollars per pound.
* In the Chiloé islands, the almud (a Spanish unit) is used as a volume measurement for "drys" (between six or eight litres).
* McDonald's sells its Quarter Pounder with cheese as "Cuarto de Libra con Queso", which translates from Spanish as "Quarter Pound with Cheese".
* Like in most countries, aviation (altitude and flight level) is measured in feet.
# Zero Tolerance (1994 film)

Zero Tolerance is a 1994 American action film from PM Entertainment Group directed by Joseph Merhi and starring Robert Patrick and Mick Fleetwood.

## Plot

After surviving a sneak attack on himself and fellow feds Jimmy (William Steis) and Gene (Michael Gregory) as they transport Mafia boss Raymond Manta (Titus Welliver) out of a Mexican jail, FBI agent Jeff Douglas (Robert Patrick) becomes an unwitting pawn of the White Hand drug cartel.
The White Hand lies to Jeff and says that his family is being held hostage and he has to help them smuggle a huge drug shipment to get them released unharmed, Jeff is forced to turn one-time courier for the White Hand, whose leaders are Manta and four others—Helmut Vitch (Mick Fleetwood), Milt Kowalski (Miles O'Keeffe), Russ LaFleur (Jeffrey Anderson-Gunter), and Hansel Lee (Gustav Vintas). In truth, the cartel had already murdered his wife and two young children, and planned to kill Jeff after he succeeded in delivering their drugs.
The drugs are delivered and the White Hand sets Jeff up to be killed in a car bombing in Las Vegas, but Jeff's instincts kick in and he is only slightly injured in the blast, and the cartel thinks he is dead and gone. Jeff learns that his family was killed, and he breaks down in tears. A short time later, the FBI wants to get him back to work, but Jeff has begun planning to wipe out the White Hand cartel.
Officially censured but unofficially aided by concerned agent Megan (Kristen Meadows), whose mother was raped and murdered years ago, Jeff steals some FBI files and kicks off his cartel extermination campaign by killing Vitch in Las Vegas, at Vitch's casino.
In New Orleans, Jeff sabotages LaFleur's liquid-heroin deal with a factory fire, and then at LaFleur's night club, Jeff finishes him off in full view of a satellite hook-up watched by Manta and Kowalski at their hide-out. Kowalski does not enjoy killing and is angry that Manta's brutal murder plan is disrupting their business, which begins to anger Manta in turn.
After that, Jeff kills Lee in his heavily guarded mansion in Seattle. After Megan arrives to speed up Jeff's getaway, the couple is apprehended by local cops, and then ambushed by Manta's men.
Although Megan is captured and taken away in a helicopter, Jeff momentarily flees. Angered by Kowalski's accurate descriptions of him as a sadistic creep, Manta shoots and kills Kowalski at his complex, but endures a savage beating from Jeff who is able to rescue Megan.
Under arrest at FBI headquarters, Manta says it's not over by a long shot. Manta grabs a gun, and in an effort to disarm Manta, Jeff plows into Manta and sends him through a window. As a result, Manta takes a fall to his death, which completes Jeff's mission to wipe out the White Hand cartel.

## Cast (selection)

* Robert Patrick - Jeff Douglas
* Kristen Meadows - Megan
* Titus Welliver - Raymond Manta
* Mick Fleetwood - Helmut Vitch
* Miles O'Keeffe - Milt Kowalski
* Jeffrey Anderson-Gunter as Russ LaFleur
* Gustav Vintas as Hansel Lee

## Home video

The film was released on home video in the UK by First Independent Films, and on the Dutch Filmworks label in the Netherlands.
# Whirlo

Whirlo is a side-scrolling action-platform released by Namco on July 23, 1992 in Japan for the Super Famicom video game system, and in Europe and Australia later during the same year. The game was re-released on August 1, 1998 in Nintendo Power flash RAM cartridge format.
The game is a prequel to Valkyrie no Bōken: Toki no Kagi Densetsu and features Whirlo (known as Krino Xandra in Japan), a secondary character from the first game, in a starring role. While the character designs by Hiroshi Fuji give the game the appearance of a picture book, the degree of difficulty is high, and there are many "bad ending" scenarios.

## Gameplay

Whirlo is a side-scrolling action-platform game.

## Plot

The game is set in a time when the actions of the Valkyrie have become legendary. The story tells of events leading up to the initial meeting between the Valkyrie and Krino Xandra. At the beginning of the game, Xandra is living a peaceful and happy life deep in the countryside with his wife and son in the Land of Marvel.
One day, a huge explosion is heard throughout the land and a deadly dust falls from the sky, causing many people across the Land of Marvel to begin dying from a withering disease. One of those to be afflicted with the disease is Xandra's son, causing Xandra and his wife to be at a loss as to what to do. After overhearing talk of a marvelous curing medicine, Xandra sets out on a journey to find this medicine and save his son.

## Reception

Review scores :
| Publication | Score |
| Famitsu | 24/40 |
| GameFan | 249/400 |
| HobbyConsolas | 89/100 |
| Joypad | 51% |
| Joystick | 70% |
| Nintendo Life | |
| Superjuegos | 93/100 |
| Super Play | 88% |
| Video Games (DE) | 58% |
Whirlo was met with mixed reception from critics since its release, but fan reception was positive: in a poll taken by Family Computer Magazine, it received a score of 21.8 out of 30.
# Yamê

Emmanuel Sow (born April 19, 1993), known professionally as Yamê is a French-Cameroonian soul singer and songwriter. He is known for his single "Bécane" which reached No. 10 on Billboard's Luxembourg Songs chart, number 9 on the French Singles Chart and at number 11 on the Belgian Ultratop Wallonia Chart.

## Early life

His stage name "Yamê" is from a language in Mbo which means "The Verb". Yamê had access to the several instruments in the home music studio from an early age. Emmanuel Sow used to engage himself with his father's music, a Senegalese-Cameroonian musician known as M'backé Ngoup'Emanty, without researching the theory.

## Career

In 2020, Yamê released a mixtape titled Bantu Mixtape Vol. 1 following an extended play titled Agent 237 in 2021. On June 1, 2023, The Colors Studios called Yamê to perform his song “Bécane” and promote his debut album Elowi. The singer is also recognised for his missing tooth. Due to the attention, American producer, Timbaland composed an instrumental on Yamê's song "Quête". In January 2024, Yamê released a music video for "Bécane" which was directed by Mateo Da Silva. In February 2024, Yamê won Best Male Newcomer at the Victoires de la Musique awards.
Yamê's song "Bécane" went viral on social media after his performance on Colors Show. The song also charted No. 12 on Billboard's France Songs, No. 94 on Canadian Hot 100, No. 199 on Billboard Global 200 and many more.

## Discography
### EPs

List of studio albums, with selected chart positions and certifications :
| Title | Peak chart positions | Peak chart positions | Album details |
| Title | FRA | BEL (WA) | Album details |
| Elowi | 10 | 38 | Released: 13 October 2023 Label: DBS, Naïve Formats: CD, Digital download |

### Mixtapes

List of mixtapes with selected details :
| Title | Details |
| Bantu Mixtape Vol. 1 | Released: 5 September 2020 Label: Formats: Digital download |
| Bantu Mixtape Vol. 2 | Released: 26 December 2020 Label: Formats: Digital download |

### Singles

| Single | Year | Peak chart positions | Peak chart positions | Peak chart positions | Album |
| Single | Year | FRA | BEL (WA) | SWI | Album |
| "Mouf" | 2020 | — | — | — | Non-album singles |
| "Gimme a ride" | 2021 | — | — | — | Non-album singles |
| "Carré d'as" | 2021 | — | — | — | Agent 237 |
| "B.4.6" | 2021 | — | — | — | Non-album singles |
| "BB Démarre" | 2021 | — | — | — | Non-album singles |
| "Kodjo" | 2022 | — | — | — | Non-album singles |
| "Call of Valhalla" | 2023 | — | — | — | Elowi |
| "Bécane" | 2023 | 9 | 11 | 27 | Elowi |

## Awards and nominations

| Year | Award | Categories | Result | Ref. |
| 2024 | Victoires de la Musique | Best Male Newcomer | Won | |