# 2021–22 UEFA Youth League knockout phase

The 2021–22 UEFA Youth League knockout phase began on 8 February 2022 with the play-off round and ended with the final on 25 April 2022 at Colovray Stadium in Nyon, Switzerland, to decide the champions of the 2021–22 UEFA Youth League. All matches were played across 90 minutes and penalty shoot-out if necessary.
Times are CET/CEST.

## Format

The mechanism of the draws for each round was as follows:
* In the draw for the knockout round play-offs, the eight second round winners from the Domestic Champions Path were drawn against the eight group runners-up from the UEFA Champions League Path, with the teams from the Domestic Champions Path hosting the match. Teams from the same association could not be drawn against each other.
* In the draw for the round of 16, there were no seedings, and the sixteen teams (eight UEFA Champions League Path group winners and eight play-off winners) were drawn into eight ties. Teams from the same UEFA Champions League Path group could not be drawn against each other, but teams from the same association could be drawn against each other. The draw also decided the home team for each round of 16 match.
* In the draws for the quarter-finals onwards, there were no seedings, and teams from the same UEFA Champions League Path group or the same association could be drawn against each other (the identity of the quarter-final winners and onwards was not known at the time of the draws). The draws also decided the home team for each quarter-final, and which quarter-final and semi-final winners were designated as the "home" team for each semi-final and final (for administrative purposes as they were played at a neutral venue).

## Qualified teams

| Group | Winners (enter round of 16) | Runners-up (enter play-offs as away team) |
| A | Paris Saint-Germain | Club Brugge |
| B | Liverpool | Atlético Madrid |
| C | Sporting CP | Borussia Dortmund |
| D | Real Madrid | Inter Milan |
| E | Benfica | Dynamo Kyiv |
| F | Manchester United | Villarreal |
| G | Red Bull Salzburg | Sevilla |
| H | Juventus | Chelsea |

### Domestic Champions Path

* Second round winners (enter play-offs as home team)
* Hajduk Split
* Genk
* Deportivo La Coruña
* Žilina
* Empoli
* Midtjylland
* AZ
* Rangers

## Schedule

Knockout phase schedule :
| Phase | Round | Draw date | Match dates |
| Knockout phase | Knockout round play-offs | 14 December 2021 | 8–9 February 2022 |
| Knockout phase | Round of 16 | 14 February 2022 | 1–2 March, 7 April 2022 |
| Knockout phase | Quarter-finals | 14 February 2022 | 15–16 March, 13 April 2022 |
| Knockout phase | Semi-finals | 14 February 2022 | 22 April 2022 at Colovray Stadium, Nyon |
| Knockout phase | Final | 14 February 2022 | 25 April 2022 at Colovray Stadium, Nyon |

## Bracket

| Knockout round play-offs | Knockout round play-offs | Knockout round play-offs | Round of 16 | Round of 16 | Round of 16 | Quarter-finals | Quarter-finals | Quarter-finals | Semi-finals | Semi-finals | Semi-finals | Final | Final | Final |
| | | | Manchester United | Manchester United | 2 (1) | | | | | | | |
| Empoli | Empoli | 3 | Borussia Dortmund (p) | Borussia Dortmund (p) | 2 (3) | | | | | | | |
| Empoli | Empoli | 3 | Borussia Dortmund (p) | Borussia Dortmund (p) | 2 (3) | Borussia Dortmund | Borussia Dortmund | 0 | | | | |
| Borussia Dortmund | Borussia Dortmund | 5 | | | | Borussia Dortmund | Borussia Dortmund | 0 | | | | |
| Borussia Dortmund | Borussia Dortmund | 5 | | | | Atlético Madrid | Atlético Madrid | 1 | | | | |
| | | | Real Madrid | Real Madrid | 2 | Atlético Madrid | Atlético Madrid | 1 | | | | |
| | | | Real Madrid | Real Madrid | 2 | | | | 22 April – Nyon | 22 April – Nyon | 22 April – Nyon | | | |
| Hajduk Split | Hajduk Split | 0 (2) | Atlético Madrid | Atlético Madrid | 3 | | | | 22 April – Nyon | 22 April – Nyon | 22 April – Nyon | |
| Hajduk Split | Hajduk Split | 0 (2) | Atlético Madrid | Atlético Madrid | 3 | | | | Atlético Madrid | Atlético Madrid | 0 | |
| Atlético Madrid (p) | Atlético Madrid (p) | 0 (3) | | | | | | | Atlético Madrid | Atlético Madrid | 0 | |
| Atlético Madrid (p) | Atlético Madrid (p) | 0 (3) | | | | | | | Red Bull Salzburg | Red Bull Salzburg | 5 | |
| | | | Paris Saint-Germain | Paris Saint-Germain | 2 | | | | Red Bull Salzburg | Red Bull Salzburg | 5 | |
| Rangers | Rangers | 0 | Sevilla | Sevilla | 0 | | | | | | | |
| Rangers | Rangers | 0 | Sevilla | Sevilla | 0 | Paris Saint-Germain | Paris Saint-Germain | 1 | | | | |
| Sevilla | Sevilla | 1 | | | | Paris Saint-Germain | Paris Saint-Germain | 1 | | | | |
| Sevilla | Sevilla | 1 | | | | Red Bull Salzburg | Red Bull Salzburg | 3 | | | | |
| | | | Žilina | Žilina | 1 (3) | Red Bull Salzburg | Red Bull Salzburg | 3 | | | | |
| | | | Žilina | Žilina | 1 (3) | | | | | | | 25 April – Nyon | 25 April – Nyon | 25 April – Nyon |
| Žilina | Žilina | 3 | Red Bull Salzburg (p) | Red Bull Salzburg (p) | 1 (4) | | | | | | | 25 April – Nyon | 25 April – Nyon | 25 April – Nyon |
| Žilina | Žilina | 3 | Red Bull Salzburg (p) | Red Bull Salzburg (p) | 1 (4) | | | | | | | Red Bull Salzburg | Red Bull Salzburg | 0 |
| Inter Milan | Inter Milan | 1 | | | | | | | | | | Red Bull Salzburg | Red Bull Salzburg | 0 |
| Inter Milan | Inter Milan | 1 | | | | | | | | | | Benfica | Benfica | 6 |
| | | | AZ | AZ | 0 (4) | | | | | | | Benfica | Benfica | 6 |
| AZ (p) | AZ (p) | 3 (4) | Juventus (p) | Juventus (p) | 0 (5) | | | | | | | | | |
| AZ (p) | AZ (p) | 3 (4) | Juventus (p) | Juventus (p) | 0 (5) | Juventus | Juventus | 2 | | | | | | |
| Villarreal | Villarreal | 3 (3) | | | | Juventus | Juventus | 2 | | | | | | |
| Villarreal | Villarreal | 3 (3) | | | | Liverpool | Liverpool | 0 | | | | | | |
| | | | Liverpool (p) | Liverpool (p) | 1 (4) | Liverpool | Liverpool | 0 | | | | | | |
| | | | Liverpool (p) | Liverpool (p) | 1 (4) | | | | 22 April – Nyon | 22 April – Nyon | 22 April – Nyon | | | |
| Genk | Genk | 5 | Genk | Genk | 1 (3) | | | | 22 April – Nyon | 22 April – Nyon | 22 April – Nyon | | | |
| Genk | Genk | 5 | Genk | Genk | 1 (3) | | | | Juventus | Juventus | 2 (3) | | | |
| Chelsea | Chelsea | 1 | | | | | | | Juventus | Juventus | 2 (3) | | | |
| Chelsea | Chelsea | 1 | | | | | | | Benfica (p) | Benfica (p) | 2 (4) | | | |
| | | | Dynamo Kyiv | Dynamo Kyiv | 1 | | | | Benfica (p) | Benfica (p) | 2 (4) | | | |
| Deportivo La Coruña | Deportivo La Coruña | 2 (2) | Sporting CP | Sporting CP | 2 | | | | | | | | | |
| Deportivo La Coruña | Deportivo La Coruña | 2 (2) | Sporting CP | Sporting CP | 2 | Sporting CP | Sporting CP | 0 | | | | | | |
| Dynamo Kyiv (p) | Dynamo Kyiv (p) | 2 (3) | | | | Sporting CP | Sporting CP | 0 | | | | | | |
| Dynamo Kyiv (p) | Dynamo Kyiv (p) | 2 (3) | | | | Benfica | Benfica | 4 | | | | | | |
| | | | Midtjylland | Midtjylland | 2 | Benfica | Benfica | 4 | | | | | | |
| Midtjylland | Midtjylland | 3 | Benfica | Benfica | 3 | | | | | | | | | |
| Club Brugge | Club Brugge | 2 | | | | | | | | | | | | |

## Knockout round play-offs
### Summary

The draw was conducted on 14 December 2021 12:00 CET at the UEFA headquarters in Nyon. The knockout round play-offs were played over one leg on 8 and 9 February 2022.
| Home team | Score | Away team |
| Empoli | 3–5 | Borussia Dortmund |
| Genk | 5–1 | Chelsea |
| AZ | 3–3 (4–3 p) | Villarreal |
| Žilina | 3–1 | Inter Milan |
| Hajduk Split | 0–0 (2–3 p) | Atlético Madrid |
| Midtjylland | 3–2 | Club Brugge |
| Deportivo La Coruña | 2–2 (2–3 p) | Dynamo Kyiv |
| Rangers | 0–1 | Sevilla |

### Matches
## Round of 16
### Summary

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The round of 16 was played over one leg on 1 March, 2 March and 7 April 2022.
| Home team | Score | Away team |
| Liverpool | 1–1 (4–3 p) | Genk |
| Real Madrid | 2–3 | Atlético Madrid |
| AZ | 0–0 (4–5 p) | Juventus |
| Dynamo Kyiv | 1–2 | Sporting CP |
| Manchester United | 2–2 (1–3 p) | Borussia Dortmund |
| Žilina | 1–1 (3–4 p) | Red Bull Salzburg |
| Paris Saint-Germain | 2–0 | Sevilla |
| Midtjylland | 2–3 | Benfica |

### Matches
## Quarter-finals
### Summary

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The quarter-finals were played over one leg from 15 March to 13 April 2022.
| Home team | Score | Away team |
| Juventus | 2–0 | Liverpool |
| Paris Saint-Germain | 1–3 | Red Bull Salzburg |
| Sporting CP | 0–4 | Benfica |
| Borussia Dortmund | 0–1 | Atlético Madrid |

### Matches
## Semi-finals
### Summary

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The semi-finals were played over one leg on 22 April 2022 at Colovray Stadium, Nyon.
| Team 1 | Score | Team 2 |
| Juventus | 2–2 (3–4 p) | Benfica |
| Atlético Madrid | 0–5 | Red Bull Salzburg |

### Matches
## Final

The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon. The final was played on 25 April 2022 at Colovray Stadium, Nyon.
This was a replay of the 2017 UEFA Youth League Final, which Salzburg won 2–1. Benfica won 6–0 to win their first Youth League title, and their first title in European football since the 1961–62 European Cup.