OpenLLM-France/wikimedia huggingface dataset:
# KiSS1-derived peptide receptor

The KiSS1-derived peptide receptor (also known as GPR54 or the Kisspeptin receptor) is a G protein-coupled receptor which binds the peptide hormone kisspeptin (metastin). Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues. Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell.
Kisspeptins are neuropeptides synthesized in the hypothalamus and encoded by the KISS1 gene. The KISS1 gene encodes the G protein-coupled receptor 54 (known as KISS1R or GPR54) and plays a crucial role in regulating reproduction, pubertal maturation, and metabolic function. KISS1 neurons located in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) project to GnRH neurons in the median eminence, which expresses KISS1R, to stimulate LH secretions in a pulsatile manner from the anterior pituitary to initiate ovulation/ pubertal maturation. The KISS1 and KISS1R/GPR54 genes have been detected in the brain, pituitary, placenta, pancreas, liver, and small intestine.

## Function

Kisspeptin is involved in the regulation of endocrine function and the onset of puberty, with activation of the kisspeptin receptor triggering release of gonadotropin-releasing hormone (GnRH), and release of kisspeptin itself being inhibited by oestradiol but enhanced by GnRH. Reductions in kisspeptin levels with age may conversely be one of the reasons behind age-related declines in levels of other endocrine hormones such as luteinizing hormone.

## Clinical significance

Alterations in the KISS1/KISS1R signaling pathway have been linked to multiple physiological conditions, including metabolic and reproductive abnormalities. A knockout model of GPR54/KISS1R in mice showed hypogonadism, and the mice failed to reach puberty. The KISS1 gene has been stated to suppress the metastasis of malignant melanomas. KISS1R signaling pathway has been characterized in the suppression of tumors and has anti-metastatic effects in several cancers, including breast cancer.
Activation of KISS1R elicits a neuroendocrine response leading to pubertal maturation. This is indicated by intermittent kisspeptin-10 administration to pre-pubertal animals resulting in activation of the hypothalamic-pituitary axis and subsequent precocious puberty in rats and primates. Mutations in the kisspeptin receptor KISS1R have resulted in isolated hypogonadotropic hypogonadism (IHH), characterized by delayed or absence of puberty

## Ligands

No non-peptide ligands for this receptor have yet been discovered, but as of 2009 both selective agonist and antagonist peptides are known.

### Agonists

* Kisspeptin (kisspeptin-54, metastin)
* Kisspeptin-10 (112-121 C-terminal fragment)
* KISS1-305
* MVT-602 (RVT-602, TAK-448)
* TAK-683

### Antagonists

* Kisspeptin-10 analogues modified with amino substitutions
* Kisspeptin-234
# Lançon

Lançon may refer to the following places in France:
* Lançon, Ardennes, a commune in the Ardennes department
* Lançon, Hautes-Pyrénées, a commune in the Hautes-Pyrénées department
* Lançon-Provence, a commune in the Bouches-du-Rhône department
# Cane River (Jamaica)

The Cane River rises at twin sources in the vicinity of Derby Peak in eastern Saint Andrew Parish, Jamaica from where it flows south to the Caribbean Sea.
# William W. Pearson

William Winstanley Pearson was a pastor and educator, born in Manchester (U.K.) on 7 May 1881, and who died in Italy on 25 September 1923.
Pearson was the son of the Reverend Samuel Pearson, a Congregationalist minister, and his wife Bertha Eliza Pearson (née Crosfield).
He was a science graduate from Cambridge University, and went to Calcutta in 1907, where he taught Botany at the London Missionary College in Bhavanipur. He returned to England in 1911 and met Rabindranath Tagore in his own house in London. While in India, he met Mahatma Gandhi, and became a supporter of his action. He was a teacher in Tagore's school, Bolpur, and then in Shantiniketan. He translated some of Tagore's works into English.
In 1916, he became Tagore's secretary, and followed him on his journey to Japan and the United States. While in Japan, Tagore introduced him to Paul and Mirra Richard, disciples of Sri Aurobindo : they had a very strong influence on him. When Mirra settled at Pondicherry in 1920 and was known as The Mother, Pearson went there to meet Sri Aurobindo. In 1920-1921 again, he accompanied Tagore both in Europe and America.
Pearson was fatally injured in an accident on September 18, 1923, when he "fell down from a train" that was traveling from Milan to Florence, and transported to a hospital in Pistoia. According to a witness at his deathbed, Pearson's last words were "My only and one love— India"

## Works

* Introduction to a 1909 edition of Duties of Man by Joseph Mazzini
* For India, 1917
* Shantiniketan: the Bolpur School of Rabindranath Tagore, 1917
* The Dawn of a New Age, and Other Essays, 1922

## Sources

* Natl. bibliogr. of Indian lit. / gen. ed. B. S. Kesavan ; V. Y. Kulkarni, 1962, vol 1, p. 339
# Dimitris K. Papoutsis

Dimitris K. Papoutsis (Greek: Δημήτρης Κ. Παπουτσής) is a Greek businessman involved in digital marketing and communication, data analytics, and business consultancy. He is the founder & CEO of Globe One Digital, stockholder in Symbol Media and the British startup Oggit and the founder of Consolytics, an online data consolidation platform.

## Life and career

Dimitris K. Papoutsis was born in Athens on December 8, 1973, to Konstantinos Papoutsis and Marousha Skiada. In 1997, after completing degrees in Marketing and Computer Information Systems in American College of Greece, Dimitris K. Papoutsis founded Globe One Digital in Athens. The introduction of internet services for domestic and business use in Greece in 1995, led Papoutsis to offer online marketing services, a concept that was beginning to gain traction in the country at that time. In 2009, he expanded into the online sports betting (iGaming) industry and, in 2014, began a business relationship with Kaizen Gaming, a global game technology company. Around the same period, he joined the travel industry and included online travel marketing services in his business activities.
In 2013, his company’s Media department was recognized as a Google Partner, and in 2023, it was designated as a Google Ads Premier Google Partner. In 2016, Globe One Digital was included as 81st on the 'Inc. 5000 Europe' list, ranking first in Greece and fifth in Europe for Advertising & Marketing. At the Tourism Megatrends Conference in 2017, Papoutsis spoke at the event on 'Digital Accommodation Performance Marketing', discussing the management of financial performance in online advertising for hotels through Revenue Performance Management (RPM). In 2018, during the first Google Marketing Conference in Athens, he presented the integration and process of Google Analytics real-time data into the “Consolytics” (Google Analytics Add-On) platform.

### Business challenges

In the years leading up to the COVID-19 pandemic, Papoutsis attempted to sell his company to an international advertising group, but the pandemic disrupted these plans and required him to adjust his business strategy. In 2021, he acquired a 50% stake in the Bulgarian events and advertising agency Symbol Media, which later rose to 75% in 2024. In 2022, he became a shareholder in Oggit, a British startup specializing in Augmented Reality (AR) technology.

## CSR

In 2011, Dimitris Papoutsis entered a collaboration with The Smile of the Child, a Greek non-profit organization dedicated to children's rights and welfare. In December 2022, Papoutsis participated in the First Open Dialogue event titled "Act for the Future", organized by Exelixi Zois at the Stavros Niarchos Foundation, and a few months later, he provided support to Exelixi Zois’s programs aimed at assisting children in institutional care with their transition to autonomy. In April 2023, Globe One Digital provided sponsorship for Antonis Papakonstantinou, the bronze medalist at the 2024 Summer Olympics in Paris.
# Gymnastics at the 2019 SEA Games – Clubs

The clubs competition for rhythmic gymnastics at the 2019 SEA Games in Philippines was held from 6 to 7 December 2019 at Rizal Memorial Coliseum.

## Schedule

All times are Philippine Standard Time (UTC+8).
| Date | Time | Squad |
| Fri, 6 December 2019 | 12:10 | Qualification |
| Sat, 7 December 2019 | 11:00 | Final |

## Results
### Qualification

Note: Top eight qualified for final with a condition of maximum two gymnasts per nation.
| Rank | Name | Difficulty | Execution | Total |
| 1 | Koi Sie Yan (MAS) | 9.100 | 8.100 | 17.200 |
| 2 | Izzah Amzan (MAS) | 9.400 | 7.400 | 16.800 |
| 3 | Benjaporn Limpanich (THA) | 9.400 | 7.000 | 16.400 |
| 4 | Daniela Reggie Dela Pisa (PHI) | 9.600 | 6.450 | 16.050 |
| 5 | Amy Kwan (MAS) | 8.500 | 6.750 | 15.250 |
| 6 | Nguyễn Hà My (VIE) | 9.000 | 6.100 | 15.100 |
| 7 | Rayna Hoh Khai Ling (MAS) | 8.300 | 6.650 | 14.950 |
| 8 | Nat Kulsanawong (THA) | 8.400 | 6.650 | 14.950 |
| 9 | Ngo Hai Yen (VIE) | 9.300 | 6.550 | 14.850 |
| 10 | Shieldannah Sabio (PHI) | 8.000 | 5.900 | 13.900 |
| 11 | Arisa Tanthathoedtham (THA) | 8.200 | 5.500 | 13.700 |
| 12 | Leah Chew (SGP) | 7.800 | 5.750 | 13.550 |
| 13 | Avryl Tan Ying (SGP) | 7.400 | 5.000 | 12.400 |
| 14 | Alicia Lim Qian Hui (SGP) | 6.900 | 4.900 | 11.800 |
| 15 | Reyna Jean Cornel (PHI) | 6.100 | 5.650 | 11.750 |
| 16 | Carla Febri Florentina (INA) | 7.000 | 4.500 | 11.500 |
| 17 | Thalia Ester Mercilita (INA) | 6.300 | 4.550 | 10.850 |
| 18 | Marian Nicolle Medina (PHI) | 6.400 | 4.250 | 10.650 |
| 19 | Yeo Siew Lyn (SGP) | 6.300 | 4.050 | 10.350 |

### Final

| Rank | Name | Difficulty | Execution | Penalty | Total |
| | Benjaporn Limpanich (THA) | 9.800 | 7.350 | | 17.150 |
| | Koi Sie Yan (MAS) | 9.500 | 7.400 | | 16.900 |
| | Daniela Reggie Dela Pisa (PHI) | 9.400 | 6.700 | | 16.100 |
| 4 | Nguyễn Hà My (VIE) | 8.800 | 6.350 | -0.05 | 15.100 |
| 5 | Ngo Hai Yen (VIE) | 8.900 | 6.150 | | 15.050 |
| 6 | Izzah Amzan (MAS) | 9.100 | 5.750 | -0.05 | 14.800 |
| 7 | Nat Kulsanawong (THA) | 7.900 | 5.650 | | 13.550 |
| 8 | Shieldannah Sabio (PHI) | 7.200 | 5.250 | | 12.450 |
# Kadıköy, Orhaneli

Kadıköy is a neighbourhood in the municipality and district of Orhaneli, Bursa Province in Turkey. Its population is 93 (2022).
# George F. Hill

George Frederick Hill (February 1832 – October 21, 1910) was a lawyer, merchant and political figure in New Brunswick. He represented Charlotte County in the Legislative Assembly of New Brunswick from 1865 to 1866, from 1879 to 1882 and from 1892 to 1908 as a Liberal member.
He was born in Saint Stephen, New Brunswick, the son of George Stilman Hill, who had previously served in the Legislative Assembly of New Brunswick. He studied law and was admitted to practice as an attorney in 1854. Hill entered business as a merchant later that same year. He opposed Confederation. He was the Official Assignee in bankruptcy for the county from 1869 to 1878. He was named to the Legislative Council in 1882. Hill was named speaker for the council in 1887. He remained a member of the council until it was abolished in 1892. He died in 1910.
# John Andrew (archdeacon)

John Andrew (1750–1799), MA was an English cleric, Archdeacon of Barnstaple from 1798 to 1799.
# John Caldwell (cartoonist)

John F. Caldwell (March 23, 1946 – February 21, 2016) was a nationally syndicated American gag cartoonist primarily known for his work in National Lampoon and Mad, where he was a member of "The Usual Gang of Idiots."
Following his death, The Comics Reporter described him as having had "one of the most prolific and successful [cartooning] careers of the late 20th Century."

## Education

Caldwell never received any actual training as a cartoonist, but he attended the Parsons School of Design, where his general art education helped him prepare for a cartooning career. He spent 1969–70 working for the State of New York as a cartographer.

## Career

Caldwell's drawings appeared in numerous publications, including Writer's Digest, Playboy, Barron's, the New Yorker, the Wall Street Journal, Reader's Digest and Harvard Business Review. He designed greeting cards for Recycled Paper Greetings and Nobleworks.
In an oddity, one of Caldwell's better-known cartoons was never officially published. He wrote and drew a gag front cover depicting the mascot Alfred E. Neuman having taken a wrong turn away from the New York Marathon route, jogging into a murder scene, and cluelessly breaking through yellow crime scene tape in triumph. The issue, #411, was already at the printer when the 9/11 attacks happened. The joke which depicted downtown Manhattan and a dead body was no longer appropriate in light of the real world events. A replacement cover was swiftly produced, showing a closely cropped head shot of Neuman, his trademark tooth gap filled in by a small American flag.

## Death

Aged 69, Caldwell died February 21, 2016, from cancer. He was survived by his wife Diane, as well as a daughter and grandson.

## Books

* Running A Muck: A Bunch of Zany Cartoons (Writer's Digest Books, 1978) ISBN 978-0-911654-60-8
* Mug Shots: A Splendid Collection of Cartoons (Fantaco, 1980)
* The Book of Ultimates (McGraw-Hill, 1983) ISBN 978-0-07-009608-0
* Caldwell (Fawcett Columbine, 1988) ISBN 978-0-449-90266-0
* Fax This Book: Over 100 Sit-Up-and-Take-Notice Cover Sheets for Better Business (Workman, 1990) ISBN 978-0-89480-807-4
* Faxable Greeting Cards (Workman, 1991) ISBN 978-1-56305-006-0
# Domald

The Domald is a left tributary of the river Târnava Mică in Romania. It discharges into the Târnava Mică in Coroi. Its length is 17 km (11 mi) and its basin size is 59 km$^2$ (23 sq mi).
# Genographics

Genographics may refer to a number of things:
* PC-GenoGraphics, a visual database/query facility designed for reasoning with genomic data
* GenoGraphics, a generic utility for constructing and querying one-dimensional linear plots
* The Genographic Project
* Genetic genealogy gone global
# George Hewitt

George Hewitt or Hewett may refer to:
* George Hewitt (footballer) (1878–?), English footballer for Burslem Port Vale and Luton Town
* Brian George Hewitt (born 1949), English linguist specialising in Caucasian languages
* George Wattson Hewitt (1841–1916), American architect
* George Hewett (British Army officer) (1750–1840), British general and Commander-in-Chief in India and Ireland
** Hewett baronets several descendants also named George
* George Hewett, 1st Viscount Hewett (1652–1689)
* George Hewett (footballer) (born 1995), Australian rules footballer for Carlton
* George Hayley Hewett, British naval officer in the Royal Indian Navy
# Domarin

Domarin (French pronunciation:) is a commune in the Isère department in southeastern France.
# Dominion (song)

"Dominion" is a song by English rock band the Sisters of Mercy. It was released as the second single from their second studio album, Floodland, in February 1988. The version on Floodland features "Dominion" as well as a coda piece titled "Mother Russia". It was written by band frontman Andrew Eldritch and produced by Larry Alexander, Eldritch, and Jim Steinman.
The song peaked at number 7 on the Irish Singles Chart, number 13 on the UK Singles Chart, and number 30 on the Billboard Dance Club Songs chart.

## Background and composition

Eldritch has revealed the song disguises an anti-American diatribe flavoured by the Chernobyl nuclear disaster. At the time of release he also claimed that the second part of the song "Mother Russia" was a call for the West to give up Berlin to the Soviets, "because in reality they already control the city. It's only stupid to pretend otherwise".
Recording of the song took place in 1987 at Power Station Studios in Manhattan, New York. Like its Steinman-produced twin "This Corrosion", "Dominion/Mother Russia" features vocals from the New York Choral Society. The full version comprises two main parts, "Dominion" and "Mother Russia", with "Dominion" being released as a standalone single.
The B-side "Ozymandias" is simply an edit of "Dominion", with most layers of the track played backwards except for the drums. When "Ozymandias" is itself in full played backwards, it sounds simply like a remix of "Dominion" with backwards-echoed drums, in a similar fashion to the drum layer in "Peek-a-Boo" by Siouxsie and the Banshees. "Sandstorm" consists of various sampled saxophone and keyboard parts from "Dominion", mixed to a moody short instrumental track, which was used in the opening section of the video. "Untitled" is a slowed-down instrumental excerpt from "Dominion". A cover of the song "Emma" by Hot Chocolate is also included.

## Track listing

All songs written by Andrew Eldritch except "Emma", written by Errol Brown and Tony Wilson.

## Charts

| Chart (1988) | Peak position |
| Ireland (IRMA) | 7 |
| UK Singles (OCC) | 13 |
| US Dance Club Songs (Billboard) | 30 |
# Donald Alexander Stewart

Donald Alexander Stewart FRIBA (6 July 1876 – 16 January 1940) was a Scottish architect, prominent in the first half of the 20th century. His design genre varied between commercial buildings, schools and churches, but he worked almost exclusively in Perthshire.

## Early life

Smart was born on 6 July 1876, son of Alexander Stewart, an innkeeper, and Christina McPherson.
He was educated at Sharp's Institution in Perth, Perthshire, and articled to David Smart, of Alyth, from August 1892.

## Career

Stewart worked in partnership with Smart's son, James, as D & J Smart. From 1896, after working in the office of Edinburgh's James Graham Fairley, he was David Smart's senior assistant, a role in which he remained until 1907, when he became partner. The firm name became Smart & Stewart.
In 1911, he emigrated to Edmonton, Alberta, Canada, where he worked for Roland Walter Lines and then as chief draughtsman and, later, chief architect to the Edmonton Public School Board.
He returned to Scotland on war service in 1916 and chose to stay.
In 1919, Stewart was an assistant to Robert Matthew Mitchell, who made him partner five years later. The firm became Smart, Stewart & Mitchell.
Stewart was elected a Fellow of the Royal Institute of British Architects (FRIBA) in November 1929.

### Selected notable works

* Old Academy, Perth (1908) – alterations to preparatory department
* J. Pullar and Sons Dyeworks, Perth (1919) – reconstruction after it had been taken over by Eastman of London
* Royal George Hotel, Perth (1927) – reconstruction

## Personal life

Stewart married twice, first to Georgina McDougall, then to May Isobel Elliot.

## Death

Stewart died on 16 January 1940, aged 63.
# John Dahlgren

John Dahlgren may refer to:
* John A. Dahlgren, United States Navy officer
* John Olof Dahlgren, United States Marine Corps corporal and Medal of Honor recipient
* John Vinton Dahlgren, American lawyer
# George I

George I or 1 may refer to:

## People

* Patriarch George I of Alexandria (fl. 621–631)
* George I of Constantinople (d. 686)
* George of Beltan (d. 790)
* George I of Abkhazia (ruled 872/3–878/9)
* George I of Georgia (d. 1027)
* Yuri Dolgorukiy (c. 1099–1157), George I of Kiev/Russia
* George I of Duklja, King of Duklja (1113–1118, and again 1125–1131)
* George I of Bulgaria (d. 1308/9)
* Yuri I of Galicia (c. 1252–1308)
* George I of Imereti (fl. late 1300s)
* George I, Prince of Anhalt-Dessau (c. 1390–1474)
* George VIII of Georgia (1417–1476), George I of Kakheti
* George I of Münsterberg (1470–1502)
* George I of Brieg (c. 1482–1521)
* George I, Duke of Pomerania (1493–1531)
* George I of Württemberg-Mömpelgard (1498–1558)
* George I, Landgrave of Hesse-Darmstadt (1547–1596)
* George I Rákóczi (1593–1648), prince of Transylvania
* George I of Great Britain (1660–1727), also Elector of Hanover
* George I, Duke of Saxe-Meiningen (1761–1803)
* George I (Miskito) (d. 1777)
* George, King of Saxony (1832–1904)
* George I of Greece (1845–1913)

## Other uses

* GEORGE 1, version of GEORGE operating system
# George I. Barnett

George Ingham Barnett (1815–1898) was an architect from St. Louis, Missouri. He was called "The Dean of St. Louis Architecture" for his contributions to the buildings of St. Louis as well as for his influence on other architects in the United States.

## Early life in England

Barnett was born in Nottingham, England. He completed a classical education by the age of 16, then trained with Sir Thomas Hine at a builder in Nottingham, and then took on an apprenticeship with an architectural firm in London. Barnett left England for the United States in early 1839, remaining in New York City for six months before departing for St. Louis.

## Work in St. Louis and Illinois

Barnett designed hundreds of buildings in St. Louis, many in Greek Revival, Italianate, and Gothic design. Barnett did not deviate from classical designs, and his portfolio was largely responsible for establishing Classicism as St. Louis' dominant architectural influence. His works included houses, churches, commercial, and civic structures. Among his best known structures are renovations to the Old Courthouse, the Missouri Governor's mansion, the structures of the Missouri Botanical Garden, Tower Grove Park, and the Southern Hotel. The Samuel Moody Grubbs House in Litchfield Illinois. The only structure in Illinois he designed. It is a second Empire design.
Barnett died at his home in St. Louis on December 29, 1898.
* Tower Grove House, 1849
* Old Courthouse, completed 1864
* Grand Avenue Water Tower, 1871
* Missouri Governor's Mansion, 1871
* Tower Grove Park, 1875
* Henry Shaw Mausoleum, 1889

## Influence on other architects

Barnett's son, Thomas P. Barnett, trained with the elder Barnett and went on to design such American landmarks as the Cathedral Basilica of St. Louis and the Adolphus Hotel in Dallas. His other son, George D. Barnett, and his son-in-law, John Ignatius Haynes, joined Tom Barnett to form the architectural firm of Barnett, Haynes & Barnett. His eldest son, Absalom J. Barnett, became a successful architect in San Francisco.
Other notable architects who apprenticed under Barnett included Henry G. Isaacs, Alfred H. Piquenard, Charles F. May, H. William Kirchner, Isaac S. Taylor and George S. Mills.
# Don goat

The Don goat breed from the Don River of the Lower Volga territory in Russia is used for the production of wool, goatskin, and milk. It produces the highest average wool per individual goat sheared of any goat breed and produces milk with a relatively high fat content.

## Sources

* Don Goats
* This goat-related article is a stub. You can help Wikipedia by expanding it.
* v
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* e