# 2021 San Francisco 49ers season

The 2021 season was the San Francisco 49ers' 72nd season in the National Football League (NFL), their 76th overall and their fifth under the head coach/general manager tandem of Kyle Shanahan and John Lynch. In honor of the 75th anniversary of the team's founding in 1946, the 49ers introduced a commemorative logo to be used during this season.
They improved from their 6–10 record from the previous year and they returned to the playoffs after a one-year absence. Despite starting 2–0, they would lose 4 consecutive games. After an embarrassing Week 9 loss to an injury depleted Arizona Cardinals, the 49ers had a disappointing 3–5 record, but they would rebound and end the season winning 7 of their last 9 games, including a dramatic Week 18 win over the Los Angeles Rams in which the 49ers fought back from a 17–0 deficit to win 27–24 in overtime, thus allowing them to sneak into the playoffs. During the season, the 49ers showcased a well rounded team, finishing top 10 in both total offense and total defense. The offense averaged 376 yards a game, good for 8th in the league, while averaging 25.1 points a game. The defense was even better, giving up just 310 yards a game, good for 3rd overall. This included the 6th best pass defense and 7th best rush defense. The defense also generated 48 sacks during the season, 5th best in the league.
In the wild-card round, the 49ers upset the Dallas Cowboys 23–17. They would then upset the #1 seeded Green Bay Packers 13–10 in the divisional round, thus advancing to the NFC Championship for the second time in 3 years. However, they lost to their division rival and eventual Super Bowl champion Los Angeles Rams 20-17.

## Offseason
### Roster changes
#### Free agency

The 49ers entered free agency with the following:
| Position | Player | Free agency tag | Date Signed | 2021 Team | Notes |
| OT | Trent Williams | UFA | March 23, 2021 | San Francisco 49ers | Signed six-year contract |
| CB | Richard Sherman | UFA | September 29, 2021 | Tampa Bay Buccaneers | Signed one-year contract |
| DE | Solomon Thomas | UFA | March 19, 2021 | Las Vegas Raiders | Signed one-year contract |
| FS | Jaquiski Tartt | UFA | March 22, 2021 | San Francisco 49ers | Signed one-year contract |
| FB | Kyle Juszczyk | UFA | March 15, 2021 | San Francisco 49ers | Signed five-year contract |
| RB | Tevin Coleman | UFA | March 25, 2021 | New York Jets | Signed one-year contract |
| WR | Kendrick Bourne | UFA | March 19, 2021 | New England Patriots | Signed three-year contract |
| CB | K'Waun Williams | UFA | March 26, 2021 | San Francisco 49ers | Signed one-year contract |
| OT | Tom Compton | UFA | April 28, 2021 | San Francisco 49ers | Signed one-year contract |
| DE | Ronald Blair | UFA | June 1, 2021 | New York Jets | Signed one-year contract |
| C | Ben Garland | UFA | | | |
| DE | Kerry Hyder | UFA | March 25, 2021 | Seattle Seahawks | Signed three-year contract |
| DE | Ezekiel Ansah | UFA | | | |
| RB | Jerick McKinnon | UFA | May 1, 2021 | Kansas City Chiefs | Signed one-year contract |
| C | Tony Bergstrom | UFA | | | |
| CB | Jason Verrett | UFA | April 1, 2021 | San Francisco 49ers | Signed one-year contract |
| CB | Ahkello Witherspoon | UFA | March 19, 2021 | Seattle Seahawks | Signed one-year contract |
| CB | Dontae Johnson | UFA | March 19, 2021 | San Francisco 49ers | Signed one-year contract |
| C | Hroniss Grasu | UFA | | | |
| DE | Dion Jordan | UFA | | | |
| CB | Jamar Taylor | UFA | | | |
| DE | Jordan Willis | UFA | March 23, 2021 | San Francisco 49ers | Signed one-year contract |
| QB | C. J. Beathard | UFA | March 24, 2021 | Jacksonville Jaguars | Signed two-year contract |
| LB | Joe Walker | UFA | May 19, 2021 | Washington Football Team | |
| QB | Nick Mullens | RFA | June 14, 2021 | Philadelphia Eagles | Signed one-year contract |
| TE | Ross Dwelley | RFA | March 5, 2021 | San Francisco 49ers | Signed one-year contract |
| LS | Taybor Pepper | RFA | February 4, 2021 | San Francisco 49ers | Signed two-year contract |
| RB | Jeff Wilson | RFA | January 26, 2021 | San Francisco 49ers | Signed one-year contract |
| QB | Josh Rosen | ERFA | February 8, 2021 | San Francisco 49ers | Signed one-year contract |
| CB | Emmanuel Moseley | ERFA | March 15, 2021 | San Francisco 49ers | Signed two-year contract |
| OT | Daniel Brunskill | ERFA | April 13, 2021 | San Francisco 49ers | Signed one-year contract |
| CB | Ken Webster | ERFA | January 21, 2021 | San Francisco 49ers | Signed one-year contract |
| WR | River Cracraft | ERFA | February 22, 2021 | San Francisco 49ers | Signed one-year contract |
| WR | Trent Taylor | UFA | May 17, 2021 | Cincinnati Bengals | Signed one-year contract |
| DT | D. J. Jones | UFA | March 22, 2021 | San Francisco 49ers | Signed one-year contract |
| S | Marcell Harris | RFA | March 5, 2021 | San Francisco 49ers | Signed one-year contract |
| RB | Austin Walter | ERFA | February 8, 2021 | San Francisco 49ers | Signed one-year contract |
| RFA: Restricted free agent, UFA: Unrestricted free agent, ERFA: Exclusive rights free agent LEGEND  – Light green background indicates a player has been re-signed by the 49ers.  – Light red background indicates a player has departed the 49ers. ||||||

#### Signings

| Position | Player | 2020 Team | Date signed | Notes |
| CB | Mark Fields | | October 13, 2020 | Claimed off waivers |
| CB | Briean Boddy-Calhoun | | March 17, 2021 | Signed one-year contract |
| TE | Daniel Helm | | March 17, 2021 | Signed one-year contract |
| C | Alex Mack | Atlanta Falcons | March 18, 2021 | Signed three-year contract |
| LB | Samson Ebukam | Los Angeles Rams | March 18, 2021 | Signed two-year contract |
| WR | Trent Sherfield | Arizona Cardinals | March 19, 2021 | Signed one-year contract |
| S | Tavon Wilson | Indianapolis Colts | March 22, 2021 | Signed one-year contract |
| DT | Zach Kerr | Carolina Panthers | March 23, 2021 | Signed one-year contract |
| LB | Nathan Gerry | Philadelphia Eagles | March 29, 2021 | Signed one-year contract |
| WR | Mohamed Sanu | Detroit Lions | March 30, 2021 | Signed one-year contract |
| QB | Nate Sudfeld | Philadelphia Eagles | April 7, 2021 | Signed one-year contract |
| RB | Wayne Gallman | New York Giants | April 21, 2021 | Signed one-year contract |
| DT | Maurice Hurst Jr. | Las Vegas Raiders | April 23, 2021 | Signed one-year contract |
| DE | Arden Key | Las Vegas Raiders | April 23, 2021 | Signed one-year contract |
| WR | Marqise Lee | New England Patriots | May 17, 2021 | Signed one-year contract |
| WR | Bennie Fowler | New Orleans Saints | May 21, 2021 | Signed one-year contract |
| WR | Andy Jones | | June 1, 2021 | Signed one-year contract |
| LB | James Burgess | Green Bay Packers | June 2, 2021 | Signed one-year contract |
| TE | MyCole Pruitt | Tennessee Titans | June 2, 2021 | Signed one-year contract |
| S | Tony Jefferson | | June 7, 2021 | Signed one-year contract |
| OG | Senio Kelemete | Houston Texans | June 11, 2021 | Signed one-year contract |
| WR | Nsimba Webster | Los Angeles Rams | June 21, 2021 | claimed off waivers |
| DE | Eddie Yarbrough | Minnesota Vikings | July 27, 2021 | Signed one-year contract |
| DE | Anthony Zettel | New Orleans Saints | July 27, 2021 | Signed one-year contract |
| TE | Jordan Matthews | | July 31, 2021 | Signed one-year contract |
| TE | Joshua Perkins | | August 4, 2021 | Signed one-year contract |
| CB | B. W. Webb | | August 4, 2021 | Signed one-year contract |
| LB | Davin Bellamy | | August 6, 2021 | Signed one-year contract |
| LB | Shilique Calhoun | New England Patriots | August 10, 2021 | Signed one-year contract |
| CB | Alexander Myres | Detroit Lions | August 10, 2021 | Signed one-year contract |
| LB | Donald Payne | | August 11, 2021 | Signed one-year contract |
| S | Ha Ha Clinton-Dix | | August 12, 2021 | Signed one-year contract |
| DT | Eddie Vanderdoes | Houston Texans | August 12, 2021 | Signed one-year contract |
| LB | Mychal Kendricks | | August 16, 2021 | Signed one-year contract |
| CB | Davontae Harris | Baltimore Ravens | August 17, 2021 | Claimed off waivers |
| OT | Corbin Kaufusi | | August 27, 2021 | Signed one-year contract |
| WR | River Cracraft | | August 28, 2021 | Signed one-year contract |
| CB | Josh Norman | Buffalo Bills | September 6, 2021 | Signed one-year contract |
| CB | Dre Kirkpatrick | Arizona Cardinals | September 14, 2021 | Signed one-year contract |
| RB | Trenton Cannon | | September 15, 2021 | Claimed off waivers |
* Indicates that the player was a free agent at the end of his respective team's 2020 season.

#### Departures

| Position | Player | Date | Notes |
| DE | Ronald Blair | March 12, 2021 | Released |
| WR | Marquise Goodwin | March 17, 2021 | Released |
| TE | Chase Harrell | April 13, 2021 | Waived |
| TE | Jordan Reed | April 20, 2021 | Retired |
| CB | Adonis Alexander | May 4, 2021 | Waived |
| WR | Matt Cole | May 4, 2021 | Waived |
| S | Chris Edwards | May 4, 2021 | Waived |
| RB | Austin Walter | May 13, 2021 | Waived |
| WR | Austin Proehl | May 17, 2021 | Waived |
| WR | Marqise Lee | May 21, 2021 | Waived |
| TE | Daniel Helm | June 1, 2021 | Waived |
| QB | Josh Johnson | June 1, 2021 | Waived |
| C | Weston Richburg | June 2, 2021 | Retired |
| CB | Briean Boddy-Calhoun | June 7, 2021 | Waived |
| OG | Justin Skule | June 11, 2021 | Waived |
| LB | Nathan Gerry | July 6, 2021 | Waived |
| DE | Daeshon Hall | July 26, 2021 | Released |
| WR | Andy Jones | July 27, 2021 | Waived |
| WR | Bennie Fowler | July 31, 2021 | Released |
| CB | Tim Harris | August 4, 2021 | Waived |
| DE | Anthony Zettel | August 6, 2021 | Retired |
| CB | Mark Fields | August 10, 2021 | Waived |
| G | Isaiah Williams | August 10, 2021 | Waived |
| WR | Kevin White | August 11, 2021 | Released |
| LB | Davin Bellamy | August 12, 2021 | Waived |
| LB | James Burgess | August 16, 2021 | Waived |
| LB | Donald Payne | August 16, 2021 | Waived |
| DT | Eddie Vanderdoes | August 16, 2021 | Waived |
| TE | Joshua Perkins | August 17, 2021 | Released |
| CB | Ken Webster | August 17, 2021 | Waived |
| QB | Josh Rosen | August 17, 2021 | Waived |
| LB | Shilique Calhoun | August 24, 2021 | Released |
| CB | B. W. Webb | August 24, 2021 | Released |
| WR | River Cracraft | August 24, 2021 | Waived |
| OT | Corbin Kaufusi | August 24, 2021 | Waived |
| FS | Kai Nacua | August 27, 2021 | Released |
| WR | River Cracraft | August 28, 2021 | Waived |
| WR | Travis Benjamin | August 31, 2021 | Released |
| C | Jake Brendel | August 31, 2021 | Released |
| S | Ha Ha Clinton-Dix | August 31, 2021 | Released |
| RB | Wayne Gallman | August 31, 2021 | Released |
| CB | Dontae Johnson | August 31, 2021 | Released |
| OG | Senio Kelemete | August 31, 2021 | Released |
| TE | Jordan Matthews | August 31, 2021 | Released |
| TE | MyCole Pruitt | August 31, 2021 | Released |
| QB | Nate Sudfeld | August 31, 2021 | Released |
| DE | Eddie Yarbrough | August 31, 2021 | Released |
| DE | Alex Barrett | August 31, 2021 | Waived |
| WR | River Cracraft | August 31, 2021 | Waived |
| DT | Darrion Daniels | August 31, 2021 | Waived |
| FB | Josh Hokit | August 31, 2021 | Waived |
| OT | Corbin Kaufusi | August 31, 2021 | Waived |
| S | Jared Mayden | August 31, 2021 | Waived |
| OT | Colton McKivitz | August 31, 2021 | Waived |
| CB | Alexander Myres | August 31, 2021 | Waived |
| OG | Dakoda Shepley | August 31, 2021 | Waived |
| WR | Nsimba Webster | August 31, 2021 | Waived |
| CB | Dontae Johnson | September 6, 2021 | Released |

## Draft

2021 San Francisco 49ers Draft :
| Round | Selection | Player | Position | College | Notes |
| 1 | 3 | Trey Lance | QB | North Dakota State | From Houston via Miami |
| 2 | 48 | Aaron Banks | OG | Notre Dame | From Las Vegas |
| 3 | 88 | Trey Sermon | RB | Ohio State | From Los Angeles Rams |
| 3 | 102 | Ambry Thomas | CB | Michigan | 2020 Resolution JC-2A picks |
| 5 | 155 | Jaylon Moore | OG | Western Michigan | |
| 5 | 172 | Deommodore Lenoir | CB | Oregon | From New Orleans |
| 5 | 180 | Talanoa Hufanga | S | USC | Compensatory pick |
| 6 | 194 | Elijah Mitchell | RB | Louisiana | |
Notes
* San Francisco traded its first-round selection (12th overall), a 2022 first-round selection, a 2022 third-round selection and a 2023 first-round selection to Miami in exchange for a first-round selection (3rd overall).
* San Francisco traded its second-round (43rd overall) and seventh-round (230th overall) selections to Vegas in exchange for a second-round (48th overall) and fourth (121st overall) selections.
* San Francisco traded 2 fourth-round selections (117th and 121st overall) to Los Angeles in exchange for a third-round selection (88th overall).
* San Francisco traded Kwon Alexander to New Orleans in exchange for a fifth-round conditional pick and LB Kiko Alonso.
* San Francisco traded its third-round and 2020 fifth-round selections to Washington in exchange for offensive tackle Trent Williams.
* San Francisco received third-round selections in 2021, 2022, and 2023, as compensation when defensive coordinator Robert Saleh was hired by the New York Jets as head coach and vice president of player personnel Martin Mayhew was hired by the Washington Football Team as general manager.
* San Francisco lost its 2021 seventh round selection, as Marquise Goodwin reverted from Philadelphia back to San Francisco.
* San Francisco acquired a seventh round selection (No. 230) and defensive end Jordan Willis from the New York Jets in exchange for a 2022 sixth round selection.

### Undrafted free agents

2021 San Francisco 49ers Undrafted Free Agents :
| Position | Player | College | Notes |
| OL | Alfredo Gutiérrez | Tecnológico de Monterrey | Waived on August 31 |
| LB | Justin Hilliard | Ohio State | Waived on August 31 |
| TE | Josh Pederson | Louisiana-Monroe | Waived on August 4 |
| LB | Elijah Sullivan | Kansas State | Waived on August 31 |
| WR | Austin Watkins | Alabama at Birmingham | Waived on August 17 |

## Preseason

The 49ers' preseason schedule was announced on May 12.
| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | August 14 | Kansas City Chiefs | L 16–19 | 0–1 | Levi's Stadium | Recap |
| 2 | August 22 | at Los Angeles Chargers | W 15–10 | 1–1 | SoFi Stadium | Recap |
| 3 | August 29 | Las Vegas Raiders | W 34–10 | 2–1 | Levi's Stadium | Recap |

## Regular season
### Schedule

The 49ers' 2021 schedule was announced on May 12.
| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | September 12 | at Detroit Lions | W 41–33 | 1–0 | Ford Field | Recap |
| 2 | September 19 | at Philadelphia Eagles | W 17–11 | 2–0 | Lincoln Financial Field | Recap |
| 3 | September 26 | Green Bay Packers | L 28–30 | 2–1 | Levi's Stadium | Recap |
| 4 | October 3 | Seattle Seahawks | L 21–28 | 2–2 | Levi's Stadium | Recap |
| 5 | October 10 | at Arizona Cardinals | L 10–17 | 2–3 | State Farm Stadium | Recap |
| 6 | Bye | Bye | Bye | Bye | Bye | Bye |
| 7 | October 24 | Indianapolis Colts | L 18–30 | 2–4 | Levi's Stadium | Recap |
| 8 | October 31 | at Chicago Bears | W 33–22 | 3–4 | Soldier Field | Recap |
| 9 | November 7 | Arizona Cardinals | L 17–31 | 3–5 | Levi's Stadium | Recap |
| 10 | November 15 | Los Angeles Rams | W 31–10 | 4–5 | Levi's Stadium | Recap |
| 11 | November 21 | at Jacksonville Jaguars | W 30–10 | 5–5 | TIAA Bank Field | Recap |
| 12 | November 28 | Minnesota Vikings | W 34–26 | 6–5 | Levi's Stadium | Recap |
| 13 | December 5 | at Seattle Seahawks | L 23–30 | 6–6 | Lumen Field | Recap |
| 14 | December 12 | at Cincinnati Bengals | W 26–23 (OT) | 7–6 | Paul Brown Stadium | Recap |
| 15 | December 19 | Atlanta Falcons | W 31–13 | 8–6 | Levi's Stadium | Recap |
| 16 | December 23 | at Tennessee Titans | L 17–20 | 8–7 | Nissan Stadium | Recap |
| 17 | January 2, 2022 | Houston Texans | W 23–7 | 9–7 | Levi's Stadium | Recap |
| 18 | January 9, 2022 | at Los Angeles Rams | W 27–24 (OT) | 10–7 | SoFi Stadium | Recap |
| Note: Intra-division opponents are in bold text. |||||||

### Game summaries
#### Week 1: at Detroit Lions

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 7 | 24 | 7 | 3 | 41 |
| Lions | 0 | 10 | 7 | 16 | 33 |
at Ford Field, Detroit, Michigan
* Date: September 12
* Game time: 1:00 p.m. EDT/10:00 a.m. PDT
* Game weather: None (indoor stadium)
* Game attendance: 59,374
* Referee: Brad Rogers
* TV announcers (Fox): Kevin Kugler, Mark Sanchez and Laura Okmin
* Recap, Game Book
Game information :
First quarter
SF – Trent Sherfield 5-yard pass from Trey Lance (Robbie Gould kick), 5:41. 49ers 7–0. Drive: 7 plays, 59 yards, 3:55.
Second quarter
DET – T. J. Hockenson 6-yard pass from Jared Goff (Austin Seibert kick), 13:29. Tied 7–7. Drive: 13 plays, 82 yards, 7:12.
SF – Elijah Mitchell 38-yard run (Robbie Gould kick), 11:12. 49ers 14–7. Drive: 4 plays, 78 yards, 2:17.
DET – Austin Seibert 49-yard field goal, 6:13. 49ers 14–10. Drive: 9 plays, 44 yards, 4:59.
SF – JaMycal Hasty 3-yard run (Robbie Gould kick), 2:25. 49ers 21–10. Drive: 7 plays, 75 yards, 3:48.
SF – Dre Greenlaw 39-yard interception return (Robbie Gould kick), 1:10. 49ers 28–10.
SF – Robbie Gould 40-yard field goal, 0:03. 49ers 31–10. Drive: 7 plays, 50 yards, 0:41.
Third quarter
SF – Deebo Samuel 79-yard pass from Jimmy Garoppolo (Robbie Gould kick), 7:54. 49ers 38–10. Drive: 5 plays, 91 yards, 2:22.
DET – D'Andre Swift 43-yard pass from Jared Goff (Austin Seibert kick), 4:23. 49ers 38–17. Drive: 7 plays, 75 yards, 3:31.
Fourth quarter
SF – Robbie Gould 52-yard field goal, 9:53. 49ers 41–17. Drive: 7 plays, 19 yards, 3:45.
DET – Jamaal Williams 1-yard run (Jared Goff–T. J. Hockenson pass), 1:53. 49ers 41–25. Drive: 12 plays, 86 yards, 3:52.
DET – Quintez Cephus 2-yard pass from Jared Goff (Jared Goff–Quintez Cephus pass), 1:07. 49ers 41–33. Drive: 6 plays, 59 yards, 0:46.
Top passers
SF – Jimmy Garoppolo – 17/25, 314 yards, TD
DET – Jared Goff – 38/57, 338 yards, 3 TD, INT
Top rushers
SF – Elijah Mitchell – 19 rushes, 104 yards, TD
DET – Jamaal Williams – 9 rushes, 54 yards, TD
Top receivers
SF – Deebo Samuel – 9 receptions, 189 yards, TD
DET – T. J. Hockenson – 8 receptions, 97 yards, TD :
49ers hold on to go up 1-0 to kick off the 75th season.

#### Week 2: at Philadelphia Eagles

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 0 | 7 | 0 | 10 | 17 |
| Eagles | 3 | 0 | 0 | 8 | 11 |
at Lincoln Financial Field, Philadelphia, Pennsylvania
* Date: September 19
* Game time: 1:00 p.m. EDT/10:00 a.m. PDT
* Game weather: Clear, 75 °F (24 °C)
* Game attendance: 69,796
* Referee: Brad Allen
* TV announcers (Fox): Adam Amin, Mark Schlereth and Shannon Spake
* Recap, Game Book
Game information :
First quarter
PHI – Jake Elliott 45-yard field goal, 4:45. Eagles 3–0. Drive: 11 plays, 53 yards, 4:43.
Second quarter
SF – Jauan Jennings 11-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:12. 49ers 7–3. Drive: 12 plays, 97 yards, 4:08.
Third quarter
No scoring plays.
Fourth quarter
SF – Jimmy Garoppolo 1-yard run (Robbie Gould kick), 10:52. 49ers 14–3. Drive: 16 plays, 92 yards, 8:59.
SF – Robbie Gould 46-yard field goal, 5:07. 49ers 17–3. Drive: 9 plays, 53 yards, 3:10.
PHI – Jalen Hurts 1-yard run (Kenneth Gainwell run), 4:02. 49ers 17–11. Drive: 5 plays, 75 yards, 1:05.
Top passers
SF – Jimmy Garoppolo – 22/30, 189 yards, TD
PHI – Jalen Hurts – 12/23, 190 yards
Top rushers
SF – Elijah Mitchell – 17 rushes, 42 yards
PHI – Jalen Hurts – 10 rushes, 82 yards, TD
Top receivers
SF – Deebo Samuel – 6 receptions, 93 yards
PHI – Quez Watkins – 2 receptions, 117 yards :
With the Victory, The 49ers are 2-0 on the season

#### Week 3: vs. Green Bay Packers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Packers | 10 | 7 | 0 | 13 | 30 |
| 49ers | 0 | 7 | 7 | 14 | 28 |
at Levi's Stadium, Santa Clara, California
* Date: September 26
* Game time: 5:20 p.m. PDT
* Game weather: Scattered clouds, 69 °F (21 °C)
* Game attendance: 69,853
* Referee: Jerome Boger
* TV announcers (NBC): Al Michaels, Cris Collinsworth, Michele Tafoya and Terry McAulay
* Recap, Game Book
Game information :
First quarter
GB – Mason Crosby 54-yard field goal, 10:06. Packers 3–0. Drive: 8 plays, 39 yards, 4:54.
GB – Davante Adams 1-yard pass from Aaron Rodgers (Mason Crosby kick), 3:19. Packers 10–0. Drive: 7 plays, 80 yards, 4:06.
Second quarter
GB – Aaron Jones 3-yard run (Mason Crosby kick), 1:02. Packers 17–0. Drive: 9 plays, 87 yards, 3:46.
SF – Trey Lance 1-yard run (Robbie Gould kick), 0:00. Packers 17–7. Drive: 8 plays, 32 yards, 1:02.
Third quarter
SF – Brandon Aiyuk 8-yard pass from Jimmy Garoppolo (Robbie Gould kick), 7:41. Packers 17–14. Drive: 13 plays, 83 yards, 7:19.
Fourth quarter
GB – Marquez Valdes-Scantling 12-yard pass from Aaron Rodgers (Mason Crosby kick), 13:27. Packers 24–14. Drive: 10 plays, 86 yards, 5:57.
SF – Trey Sermon 1-yard run (Robbie Gould kick), 7:48. Packers 24–21. Drive: 9 plays, 81 yards, 5:39.
GB – Mason Crosby 38-yard field goal, 2:39. Packers 27–21. Drive: 5 plays, 18 yards, 2:19.
SF – Kyle Juszczyk 12-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:37. 49ers 28–27. Drive: 8 plays, 75 yards, 2:02.
GB – Mason Crosby 51-yard field goal, 0:00. Packers 30–28. Drive: 6 plays, 42 yards, 0:37.
Top passers
GB – Aaron Rodgers – 23/33, 261 yards, 2 TD
SF – Jimmy Garoppolo – 25/40, 257 yards, 2 TD, INT
Top rushers
GB – Aaron Jones – 19 rushes, 82 yards, TD
SF – Trey Sermon – 10 rushes, 31 yards, TD
Top receivers
GB – Davante Adams – 12 receptions, 132 yards, TD
SF – George Kittle – 7 receptions, 92 yards :
The Packers narrowly escape the 49ers and deliver San Francisco its first loss on the season.

#### Week 4: vs. Seattle Seahawks

| Quarter | 1 | 2 | 3 | 4 | Total |
| Seahawks | 0 | 7 | 14 | 7 | 28 |
| 49ers | 7 | 0 | 6 | 8 | 21 |
at Levi's Stadium, Santa Clara, California
* Date: October 3
* Game time: 1:05 p.m. PDT
* Game weather: Hazy skies, 88 °F (31 °C)
* Game attendance: 68,912
* Referee: Carl Cheffers
* TV announcers (Fox): Adam Amin, Mark Schlereth and Shannon Spake
* Recap, Game Book
Game information :
First quarter
SF – Ross Dwelley 21-yard pass from Jimmy Garoppolo (Mitch Wishnowsky kick), 9:35. 49ers 7–0. Drive: 8 plays, 71 yards, 4:13.
Second quarter
SEA – DK Metcalf 12-yard pass from Russell Wilson (Jason Myers kick), 1:54. Tied 7–7. Drive: 6 plays, 80 yards, 2:55.
Third quarter
SEA – Russell Wilson 16-yard run (Jason Myers kick), 5:22. Seahawks 14–7. Drive: 7 plays, 66 yards, 3:31.
SEA – Freddie Swain 13-yard pass from Russell Wilson (Jason Myers kick), 4:26. Seahawks 21–7. Drive: 2 plays, 14 yards, 0:50.
SF – Deebo Samuel 76-yard pass from Trey Lance (kick failed), 2:10. Seahawks 21–13. Drive: 4 plays, 89 yards, 2:16.
Fourth quarter
SEA – Alex Collins 14-yard run (Jason Myers kick), 12:07. Seahawks 28–13. Drive: 10 plays, 81 yards, 5:03.
SF – Deebo Samuel 8-yard pass from Trey Lance (Trey Lance run), 1:20. Seahawks 28–21. Drive: 13 plays, 80 yards, 3:10.
Top passers
SEA – Russell Wilson – 16/23, 149 yards, 2 TD
SF – Jimmy Garoppolo – 14/23, 165 yards, TD, INT
Top rushers
SEA – Alex Collins – 10 rushes, 44 yards, TD
SF – Trey Sermon – 19 rushes, 89 yards
Top receivers
SEA – DK Metcalf – 4 receptions, 65 yards, TD
SF – Deebo Samuel – 8 receptions, 156 yards, 2 TD :
Despite a late rally, the 49ers could not hold off the Seahawks at Levi's and drop to 2–2 on the season.

#### Week 5: at Arizona Cardinals

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 0 | 0 | 7 | 3 | 10 |
| Cardinals | 7 | 3 | 0 | 7 | 17 |
at State Farm Stadium, Glendale, Arizona
* Date: October 10
* Game time: 1:25 p.m. MST & PDT
* Game weather: None (retractable roof closed)
* Game attendance: 62,716
* Referee: Clay Martin
* TV announcers (Fox): Kevin Kugler, Mark Sanchez and Laura Okmin
* Recap, Game Book
Game information :
First quarter
ARI – James Conner 1-yard run (Matt Prater kick), 9:02. Cardinals 7–0. Drive: 8 plays, 66 yards, 3:44.
Second quarter
ARI – Matt Prater 21-yard field goal, 5:27. Cardinals 10–0. Drive: 14 plays, 96 yards, 5:59.
Third quarter
SF – Deebo Samuel 13-yard run, (Joey Slye kick) 1:42. Cardinals 10–7. Drive: 6 plays, 59 yards, 3:28.
Fourth quarter
ARI – DeAndre Hopkins 9-yard pass from Kyler Murray, (Matt Prater kick) 5:13. Cardinals 17–7. Drive: 5 plays, 52 yards, 2:36.
SF – Joey Slye 47-yard field goal, 4:12. Cardinals 17–10. Drive: 6 plays, 46 yards, 1:01.
Top passers
SF – Trey Lance – 15/29, 192 yards, INT
ARI – Kyler Murray – 22/31, 239 yards, TD
Top rushers
SF – Trey Lance – 16 rushes, 89 yards
ARI – Rondale Moore – 3 rushes, 38 yards
Top receivers
SF – Deebo Samuel – 3 receptions, 58 yards
ARI – DeAndre Hopkins – 6 receptions, 87 yards, TD :
In Trey Lance's first NFL start the 49ers lose a closer than expected game and fall to 2–3 on the season.

#### Week 7: vs. Indianapolis Colts

| Quarter | 1 | 2 | 3 | 4 | Total |
| Colts | 7 | 6 | 7 | 10 | 30 |
| 49ers | 12 | 0 | 0 | 6 | 18 |
at Levi's Stadium, Santa Clara, California
* Date: October 24
* Game time: 5:20 p.m. PDT
* Game weather: Cloudy, rainy, 64 °F (18 °C)
* Game attendance: 56,576
* Referee: Craig Wrolstad
* TV announcers (NBC): Al Michaels, Cris Collinsworth, Michele Tafoya and Terry McAulay
* Recap, Game Book
Game information :
First quarter
SF – Elijah Mitchell 14-yard run (kick failed, wide right), 10:12. 49ers 6–0. Drive: 8 plays, 78 yards, 4:48.
SF – Joey Slye 34-yard field goal, 8:08. 49ers 9–0. Drive: 5 plays, 12 yards, 1:44.
IND – Mo Alie-Cox 11-yard pass from Carson Wentz (Michael Badgley kick), 5:15. 49ers 9–7. Drive: 6 plays, 75 yards, 2:53.
SF – Joey Slye 56-yard field goal, 2:27. 49ers 12–7. Drive: 6 plays, 39 yards, 2:48.
Second quarter
IND – Carson Wentz 1-yard run (pass failed) 1:00. Colts 13–12. Drive: 5 plays, 28 yards, 2:02.
Third quarter
IND – Jonathan Taylor 5-yard run (Michael Badgley kick), 3:45. Colts 20–12. Drive: 1 play, 33 yards, 0:53.
Fourth quarter
SF – Deebo Samuel 14-yard pass from Jimmy Garoppolo (pass failed), 13:07. Colts 20–18. Drive: 3 plays, 70 yards, 1:11.
IND – Michael Badgley 42-yard field goal, 7:00. Colts 23–18. Drive: 10 plays, 49 yards, 6:07.
IND – Michael Pittman Jr. 28-yard pass from Carson Wentz (Michael Badgley kick), 2:49. Colts 30–18. Drive: 6 plays, 39 yards, 2:31.
Top passers
IND – Carson Wentz – 17/26, 150 yards, 2 TD
SF – Jimmy Garoppolo – 16/27, 181 yards, TD, 2 INT
Top rushers
IND – Jonathan Taylor – 18 rushes, 107 yards, TD
SF – Elijah Mitchell – 18 rushes, 107 yards, TD
Top receivers
IND – Michael Pittman Jr. – 4 receptions, 105 yards, TD
SF – Deebo Samuel – 7 receptions, 100 yards, TD :
With their fourth loss in a row, the 49ers go down to 2–4.

#### Week 8: at Chicago Bears

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 3 | 6 | 6 | 18 | 33 |
| Bears | 3 | 10 | 3 | 6 | 22 |
at Soldier Field, Chicago, Illinois
* Date: October 31
* Game time: 12:00 p.m. CDT/10:00 a.m. PDT
* Game weather: Partly sunny, 52 °F (11 °C)
* Game attendance: 60,877
* Referee: Land Clark
* TV announcers (Fox): Adam Amin, Greg Olsen and Pam Oliver
* Recap, Game Book
Game information :
First quarter
CHI – Cairo Santos 39-yard field goal, 4:38. Bears 3–0. Drive: 9 plays, 41 yards, 5:10.
SF – Joey Slye 48-yard field goal, 2:51. Tied 3–3. Drive: 6 plays, 45 yards, 1:47.
Second quarter
CHI – Jesse James 8-yard pass from Justin Fields (Cairo Santos kick), 12:03. Bears 10–3. Drive: 11 plays, 74 yards, 5:48.
SF – Joey Slye 52-yard field goal, 9:33. Bears 10–6. Drive: 7 plays, 41 yards, 2:30.
CHI – Cairo Santos 40-yard field goal, 1:16. Bears 13–6. Drive: 16 plays, 57 yards, 8:17.
SF – Joey Slye 22-yard field goal, 0:00. Bears 13–9. Drive: 7 plays, 71 yards, 1:16.
Third quarter
CHI – Cairo Santos 25-yard field goal, 8:33. Bears 16–9. Drive: 13 plays, 62 yards, 6:27.
SF – Jimmy Garoppolo 2-yard run (kick failed, wide right), 5:56. Bears 16–15. Drive: 7 plays, 75 yards, 2:37.
Fourth quarter
SF – Elijah Mitchell 5-yard run (Jimmy Garoppolo–Brandon Aiyuk pass), 14:11. 49ers 23–16. Drive: 6 plays, 52 yards, 2:49.
CHI – Justin Fields 22-yard run (kick failed, wide right), 9:32. 49ers 23–22. Drive: 9 plays, 68 yards, 4:39.
SF – Jimmy Garoppolo 5-yard run (Joey Slye kick), 6:34. 49ers 30–22. Drive: 5 plays, 75 yards, 2:58.
SF – Joey Slye 32-yard field goal, 1:56. 49ers 33–22. Drive: 7 plays, 49 yards, 2:28.
Top passers
SF – Jimmy Garoppolo – 17/28, 322 yards
CHI – Justin Fields – 19/27, 175 yards, TD, INT
Top rushers
SF – Elijah Mitchell – 18 rushes, 137 yards, TD
CHI – Justin Fields – 10 rushes, 103 yards, TD
Top receivers
SF – Deebo Samuel – 6 receptions, 171 yards
CHI – Darnell Mooney – 6 receptions, 64 yards :
Despite struggling in the first half of the game falling behind 16–9, the 49ers would rally, outscoring the Bears 24–6 to pick up the win and improving them to 3–4.

#### Week 9: vs. Arizona Cardinals

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 14 | 3 | 14 | 0 | 31 |
| 49ers | 0 | 7 | 7 | 3 | 17 |
at Levi's Stadium, Santa Clara, California
* Date: November 7
* Game time: 1:25 p.m. PST
* Game weather: Scattered clouds, 62 °F (17 °C)
* Game attendance: 59,012
* Referee: Brad Allen
* TV announcers (Fox): Kevin Kugler, Mark Sanchez and Laura Okmin
* Recap, Game Book
Game information :
First quarter
ARI – James Conner 13-yard run (Matt Prater kick), 6:08. Cardinals 7–0. Drive: 9 plays, 57 yards, 4:21.
ARI – James Conner 1-yard run (Matt Prater kick), 0:39. Cardinals 14–0. Drive: 8 plays, 80 yards, 3:59.
Second quarter
ARI – Matt Prater 26-yard field goal, 4:02. Cardinals 17–0. Drive: 14 plays, 85 yards, 8:23.
SF – George Kittle 6-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:16. Cardinals 17–7. Drive: 9 plays, 75 yards, 3:46.
Third quarter
ARI – James Conner 45-yard pass from Colt McCoy (Matt Prater kick), 13:33. Cardinals 24–7. Drive: 3 plays, 72 yards, 1:27.
ARI – Eno Benjamin 21-yard run (Matt Prater kick), 8:05. Cardinals 31–7. Drive: 7 plays, 71 yards, 3:47.
SF – Brandon Aiyuk 11-yard pass from Jimmy Garoppolo (Robbie Gould kick), 4:56. Cardinals 31–14. Drive: 6 plays, 75 yards, 3:09.
Fourth quarter
SF – Robbie Gould 26-yard field goal, 8:23. Cardinals 31–17. Drive: 7 plays, 28 yards, 2:34.
Top passers
ARI – Colt McCoy – 22/26, 249 yards, TD
SF – Jimmy Garoppolo – 28/40, 322 yards, 2 TD, INT
Top rushers
ARI – James Conner – 21 rushes, 96 yards, 2 TD
SF – Elijah Mitchell – 8 rushes, 36 yards
Top receivers
ARI – Christian Kirk – 6 receptions, 91 yards
SF – George Kittle – 6 receptions, 101 yards, TD :
Despite the Cardinals having an injury–depleted roster, the 49ers suffer an embarrassing loss to former 49ers QB Colt McCoy and fall to 3–5 on the season.

#### Week 10: vs. Los Angeles Rams

| Quarter | 1 | 2 | 3 | 4 | Total |
| Rams | 0 | 7 | 0 | 3 | 10 |
| 49ers | 14 | 7 | 3 | 7 | 31 |
at Levi's Stadium, Santa Clara, California
* Date: November 15
* Game time: 5:15 p.m. PST
* Game weather: Overcast, 62 °F (17 °C)
* Game attendance: 64,256
* Referee: Shawn Smith
* TV announcers (ESPN): Steve Levy, Brian Griese, Louis Riddick, Lisa Salters and John Parry
* Recap, Game Book
Game information :
First quarter
SF – George Kittle 8-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:54. 49ers 7–0. Drive: 18 plays, 93 yards, 11:03.
SF – Jimmie Ward 27-yard interception return (Robbie Gould kick), 0:49. 49ers 14–0.
Second quarter
LAR – Tyler Higbee 10-yard pass from Matthew Stafford (Matt Gay kick), 13:16. 49ers 14–7. Drive: 7 plays, 75 yards, 2:33.
SF – Deebo Samuel 8-yard run (Robbie Gould kick), 5:24. 49ers 21–7. Drive: 11 plays, 91 yards, 7:52.
Third quarter
SF – Robbie Gould 50-yard field goal, 4:38. 49ers 24–7. Drive: 10 plays, 31 yards, 6:14.
Fourth quarter
SF – Deebo Samuel 40-yard pass from Jimmy Garoppolo (Robbie Gould kick), 11:07. 49ers 31–7. Drive: 6 plays, 56 yards, 3:53.
LAR – Matt Gay 37-yard field goal, 3:48. 49ers 31–10. Drive: 7 plays, 33 yards, 1:11.
Top passers
LAR – Matthew Stafford – 26/41, 243 yards, TD, 2 INT
SF – Jimmy Garoppolo – 15/19, 182 yards, 2 TD
Top rushers
LAR – Darrell Henderson Jr. – 5 rushes, 31 yards
SF – Elijah Mitchell – 27 rushes, 91 yards
Top receivers
LAR – Cooper Kupp – 11 receptions, 122 yards
SF – Deebo Samuel – 5 receptions, 97 yards, TD :
The 49ers bounced back against their interstate rivals, defeating them for the 5th consecutive time and bringing their record up to 4–5 for the season.

#### Week 11: at Jacksonville Jaguars

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 3 | 17 | 7 | 3 | 30 |
| Jaguars | 0 | 3 | 0 | 7 | 10 |
at TIAA Bank Field, Jacksonville, Florida
* Date: November 21
* Game time: 1:00 p.m. EST/10:00 a.m. PST
* Game weather: Sunny, 67 °F (19 °C)
* Game attendance: 60,268
* Referee: Ronald Torbert
* TV announcers (Fox): Chris Myers, Daryl Johnston and Jen Hale
* Recap, Game Book
Game information :
First quarter
SF – Robbie Gould 20-yard field goal, 1:55. 49ers 3–0. Drive: 20 plays, 87 yards, 13:05.
Second quarter
SF – Deebo Samuel 25-yard run (Robbie Gould kick), 11:24. 49ers 10–0. Drive: 7 plays, 80 yards, 3:56.
SF – Brandon Aiyuk 6-yard pass from Jimmy Garoppolo (Robbie Gould kick), 8:25. 49ers 17–0. Drive: 7 plays, 35 yards, 2:51.
JAX – Matthew Wright 30-yard field goal, 1:53. 49ers 17–3. Drive: 12 plays, 67 yards, 6:32.
SF – Robbie Gould 48-yard field goal, 0:00. 49ers 20–3. Drive: 7 plays, 45 yards, 1:53.
Third quarter
SF – George Kittle 1-yard pass from Jimmy Garoppolo (Robbie Gould kick), 8:49. 49ers 27–3. Drive: 11 plays, 77 yards, 5:45.
Fourth quarter
SF – Robbie Gould 45-yard field goal, 5:33. 49ers 30–3. Drive: 5 plays, 17 yards, 3:00.
JAX – James Robinson 1-yard run (Matthew Wright kick), 3:04. 49ers 30–10. Drive: 8 plays, 75 yards, 2:29.
Top passers
SF – Jimmy Garoppolo – 16/22, 176 yards, 2 TD
JAX – Trevor Lawrence – 16/25, 158 yards
Top rushers
SF – Deebo Samuel – 8 rushes, 79 yards, TD
JAX – James Robinson – 12 rushes, 29 yards, TD
Top receivers
SF – Brandon Aiyuk – 7 receptions, 85 yards, TD
JAX – Laviska Shenault – 5 receptions, 50 yards :
49ers got back to .500 by beating the Jags.

#### Week 12: vs. Minnesota Vikings

| Quarter | 1 | 2 | 3 | 4 | Total |
| Vikings | 7 | 7 | 12 | 0 | 26 |
| 49ers | 7 | 7 | 20 | 0 | 34 |
at Levi's Stadium, Santa Clara, California
* Date: November 28
* Game time: 1:25 p.m. PST
* Game weather: Clear, 67 °F (19 °C)
* Game attendance: 71,493
* Referee: Brad Rogers
* TV announcers (Fox): Kenny Albert, Jonathan Vilma, and Sara Walsh
* Recap, Game Book
Game information :
First quarter
MIN – Adam Thielen 2-yard pass from Kirk Cousins (Greg Joseph kick), 8:27. Vikings 7–0. Drive: 8 plays, 49 yards, 3:33.
SF – Deebo Samuel 20-yard run (Robbie Gould kick), 5:31. Tied 7–7. Drive: 6 plays, 75 yards, 2:56.
Second quarter
MIN – Adam Thielen 20-yard pass from Kirk Cousins (Greg Joseph kick), 12:42. Vikings 14–7. Drive: 6 plays, 80 yards, 2:50.
SF – Jauan Jennings 3-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:18. Tied 14–14. Drive: 15 plays, 85 yards, 8:20.
Third quarter
SF – Deebo Samuel 3-yard run (Robbie Gould kick), 11:31. 49ers 21–14. Drive: 6 plays, 75 yards, 3:29.
SF – Elijah Mitchell 2-yard run (Robbie Gould kick), 11:09. 49ers 28–14. Drive: 1 play, 2 yards, 0:04.
MIN – Alexander Mattison 6-yard run (kick failed, wide right), 8:28. 49ers 28–20. Drive: 5 plays, 75 yards, 2:41.
SF – Robbie Gould 46-yard field goal, 4:58. 49ers 31–20. Drive: 7 plays, 47 yards, 3:30.
MIN – Kene Nwangwu 99-yard kickoff return (pass failed), 4:46. 49ers 31–26. Drive: 0 plays, 0 yards, 0:12.
SF – Robbie Gould 22-yard field goal, 0:09. 49ers 34–26. Drive: 4 plays, 5 yards, 1:21.
Fourth quarter
No scoring plays.
Top passers
MIN – Kirk Cousins – 20/32, 238 yards, 2 TD, INT
SF – Jimmy Garoppolo – 17/26, 230 yards, TD, INT
Top rushers
MIN – Dalvin Cook – 10 rushes, 39 yards
SF – Elijah Mitchell – 27 rushes, 133 yards, TD
Top receivers
MIN – Justin Jefferson – 4 receptions, 83 yards
SF – Brandon Aiyuk – 3 receptions, 91 yards :
In a crucial game for seeding, the 49ers pulled off a late victory to take the tie breaker and went up to 6–5 on the season.

#### Week 13: at Seattle Seahawks

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 14 | 9 | 0 | 0 | 23 |
| Seahawks | 7 | 14 | 9 | 0 | 30 |
at Lumen Field, Seattle, Washington
* Date: December 5
* Game time: 1:25 p.m. PST
* Game weather: Sunny, 41 °F (5 °C)
* Game attendance: 68,758
* Referee: Alex Kemp
* TV announcers (CBS): Kevin Harlan, Tiki Barber and Melanie Collins
* Recap, Game Book
Game information :
First quarter
SEA – Travis Homer 73-yard run (Jason Myers kick), 13:11. Seahawks 7–0. Drive: 4 plays, 77 yards, 1:49.
SF – George Kittle 24-yard pass from Jimmy Garoppolo (Robbie Gould kick), 10:27. Tied 7–7. Drive: 1 play, 24 yards, 0:07.
SF – Elijah Mitchell 2-yard run (Robbie Gould kick), 1:32. 49ers 14–7. Drive: 9 plays, 54 yards, 4:10.
Second quarter
SF – Robbie Gould 50-yard field goal, 9:43. 49ers 17–7. Drive: 9 plays, 31 yards, 5:02.
SEA – Adrian Peterson 1-yard run (Jason Myers kick), 5:35. 49ers 17–14. Drive: 9 plays, 63 yards, 4:08.
SF – George Kittle 48-yard pass from Jimmy Garoppolo (kick failed), 1:48. 49ers 23–14. Drive: 7 plays, 75 yards, 3:47.
SEA – D'Wayne Eskridge 7-yard pass from Russell Wilson (Jason Myers kick), 0:12. 49ers 23–21. Drive: 8 plays, 65 yards, 1:36.
Third quarter
SEA – Carlos Dunlap sacked Jimmy Garoppolo in end zone for a safety, 10:28. Tied 23–23.
SEA – Tyler Lockett 12-yard pass from Russell Wilson (Jason Myers kick), 2:28. Seahawks 30–23. Drive: 5 plays, 28 yards, 2:09.
Fourth quarter
No scoring plays.
Top passers
SF – Jimmy Garoppolo – 20/30, 299 yards, 2 TD, 2 INT
SEA – Russell Wilson – 30/37, 231 yards, 2 TD, INT
Top rushers
SF – Elijah Mitchell – 22 rushes, 66 yards, TD
SEA – Travis Homer – 3 rushes, 80 yards, TD
Top receivers
SF – George Kittle – 9 receptions, 181 yards, 2 TD
SEA – Tyler Lockett – 7 receptions, 68 yards, TD :
The Seahawks snapped a 3 game win streak for the 49ers, as their record was evened out at 6–6.

#### Week 14: at Cincinnati Bengals

| Quarter | 1 | 2 | 3 | 4 | OT | Total |
| 49ers | 3 | 14 | 3 | 0 | 6 | 26 |
| Bengals | 3 | 3 | 0 | 14 | 3 | 23 |
at Paul Brown Stadium, Cincinnati, Ohio
* Date: December 12
* Game time: 4:25 p.m. EST/1:25 p.m. PST
* Game weather: Sunny, 45 °F (7 °C)
* Game attendance: 50,481
* Referee: Craig Wrolstad
* TV announcers (CBS): Greg Gumbel, Adam Archuleta and AJ Ross
* Recap, Game Book
Game information :
First quarter
SF – Robbie Gould 33-yard field goal, 6:37. 49ers 3–0. Drive: 4 plays, 8 yards, 2:33.
CIN – Evan McPherson 37-yard field goal, 0:31. Tied 3–3. Drive: 11 plays, 67 yards, 6:06.
Second quarter
SF – Deebo Samuel 27-yard run (Robbie Gould kick), 12:05. 49ers 10–3. Drive: 6 plays, 75 yards, 3:26.
CIN – Evan McPherson 28-yard field goal, 1:42. 49ers 10–6. Drive: 12 plays, 53 yards, 6:06.
SF – George Kittle 14-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:18. 49ers 17–6. Drive: 4 plays, 31 yards, 0:39.
Third quarter
SF – Robbie Gould 24-yard field goal, 7:43. 49ers 20–6. Drive: 12 plays, 69 yards, 5:17.
Fourth quarter
CIN – Ja'Marr Chase 17-yard pass from Joe Burrow (Evan McPherson kick), 9:20. 49ers 20–13. Drive: 6 plays, 66 yards, 2:32.
CIN – Ja'Marr Chase 32-yard pass from Joe Burrow (Evan McPherson kick), 1:19. Tied 20–20. Drive: 7 plays, 87 yards, 1:21.
Overtime
CIN – Evan McPherson 41-yard field goal, 6:15. Bengals 23–20. Drive: 7 plays, 52 yards, 3:45.
SF – Brandon Aiyuk 12-yard pass from Jimmy Garoppolo, 1:53. 49ers 26–23. Drive: 7 plays, 75 yards, 4:22.
Top passers
SF – Jimmy Garoppolo – 27/41, 296 yards, 2 TD
CIN – Joe Burrow – 25/34, 348 yards, 2 TD
Top rushers
SF – Jeff Wilson Jr. – 13 rushes, 56 yards
CIN – Joe Mixon – 18 rushes, 58 yards
Top receivers
SF – George Kittle – 13 receptions, 151 yards, TD
CIN – Tee Higgins – 5 receptions, 114 yards :
Late heroics and extra time was needed in this regular season classic, Aiyuk and the 49ers leaped to 7–6.

#### Week 15: vs. Atlanta Falcons

| Quarter | 1 | 2 | 3 | 4 | Total |
| Falcons | 3 | 7 | 3 | 0 | 13 |
| 49ers | 3 | 14 | 14 | 0 | 31 |
at Levi's Stadium, Santa Clara, California
* Date: December 19
* Game time: 1:05 p.m. PST
* Game weather: Clear, 52 °F (11 °C)
* Game attendance: 71,650
* Referee: Clay Martin
* TV announcers (CBS): Kevin Harlan, Trent Green and Melanie Collins
* Recap, Game Book
Game information :
First quarter
ATL – Younghoe Koo 48-yard field goal, 7:12. Falcons 3–0. Drive: 7 plays, 19 yards, 3:49.
SF – Robbie Gould 30-yard field goal, 1:21. Tied 3–3. Drive: 11 plays, 79 yards, 5:51.
Second quarter
SF – Kyle Juszczyk 6-yard run (Robbie Gould kick), 9:14. 49ers 10–3. Drive: 8 plays, 77 yards, 4:16.
ATL – Russell Gage 20-yard pass from Matt Ryan (Younghoe Koo kick), 4:00. Tied 10–10. Drive: 8 plays, 65 yards, 5:14.
SF – Deebo Samuel 10-yard run (Robbie Gould kick), 0:33. 49ers 17–10. Drive: 6 plays, 75 yards, 3:27.
Third quarter
SF – Jeff Wilson Jr. 5-yard run (Robbie Gould kick), 11:11. 49ers 24–10. Drive: 4 plays, 38 yards, 2:10.
ATL – Younghoe Koo 22-yard field goal, 6:28. 49ers 24–13. Drive: 9 plays, 71 yards, 4:43.
SF – Jauan Jennings 4-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:17. 49ers 31–13. Drive: 10 plays, 75 yards, 5:11.
Fourth quarter
No scoring plays.
Top passers
ATL – Matt Ryan – 19/32, 236 yards, TD
SF – Jimmy Garoppolo – 18/23, 235 yards, TD
Top rushers
ATL – Mike Davis – 6 rushes, 21 yards
SF – Jeff Wilson Jr. – 21 rushes, 110 yards, TD
Top receivers
ATL – Russell Gage – 8 receptions, 91 yards, TD
SF – George Kittle – 6 receptions, 93 yards :
The 49ers inspired 3rd Quarter put them over the Falcons and onto 8–6.

#### Week 16: at Tennessee Titans

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 7 | 3 | 0 | 7 | 17 |
| Titans | 0 | 0 | 10 | 10 | 20 |
at Nissan Stadium, Nashville, Tennessee
* Date: December 23
* Game time: 7:20 p.m. CST/5:20 p.m. PST
* Game weather: Clear, 54 °F (12 °C)
* Game attendance: 69,361
* Referee: Shawn Hochuli
* TV announcers (NFLN): Kevin Burkhardt, Greg Olsen, Pam Oliver and Kristina Pink
* Recap, Game Book
Game information :
First quarter
SF – Jeff Wilson Jr. 1-yard run (Robbie Gould kick) 9:57. 49ers 7–0. Drive: 9 plays, 75 yards, 5:03.
Second quarter
SF – Robbie Gould 48-yard field goal, 8:31. 49ers 10–0. Drive: 11 plays, 33 yards, 6:19.
Third quarter
TEN – Randy Bullock 38-yard field goal, 8:45. 49ers 10–3. Drive: 13 plays, 55 yards, 6:15.
TEN – D'Onta Foreman 3-yard run (Randy Bullock kick), 7:13. Tied 10–10. Drive: 4 plays, 18 yards, 1:23.
Fourth quarter
TEN – A. J. Brown 18-yard pass from Ryan Tannehill (Randy Bullock kick), 13:02. Titans 17–10. Drive: 7 plays, 59 yards, 3:51.
SF – Brandon Aiyuk 2-yard pass from Jimmy Garoppolo (Robbie Gould kick), 2:20. Tied 17–17. Drive: 8 plays, 95 yards, 2:58.
TEN – Randy Bullock 44-yard field goal, 0:04. Titans 20–17. Drive: 8 plays, 49 yards, 2:16.
Top passers
SF – Jimmy Garoppolo – 25/34, 322 yards, TD, 2 INT
TEN – Ryan Tannehill – 22/29, 209 yards, TD
Top rushers
SF – Jeff Wilson Jr. – 14 rushes, 45 yards, TD
TEN – Jeremy McNichols – 7 rushes, 31 yards
Top receivers
SF – Deebo Samuel – 9 receptions, 159 yards
TEN – A. J. Brown – 11 receptions, 145 yards, TD :
Despite taking a 10–0 lead, the 49ers could not overcome the Titans, who outscored them 20–7 to drop them to 8–7, making their playoff chances looking slim.

#### Week 17: vs. Houston Texans

| Quarter | 1 | 2 | 3 | 4 | Total |
| Texans | 0 | 7 | 0 | 0 | 7 |
| 49ers | 0 | 3 | 7 | 13 | 23 |
at Levi's Stadium, Santa Clara, California
* Date: January 2
* Game time: 1:05 p.m. PST
* Game weather: Clear, 64 °F (18 °C)
* Game attendance: 71,612
* Referee: Carl Cheffers
* TV announcers (CBS): Greg Gumbel, Adam Archuleta and AJ Ross
* Recap, Game Book
Game information :
First quarter
No scoring plays.
Second quarter
HOU – Brandin Cooks 8-yard pass from Davis Mills (Kaʻimi Fairbairn kick) 1:57. Texans 7–0. Drive: 14 plays, 80 yards, 7:15.
SF – Robbie Gould 37-yard field goal, 0:00. Texans 7–3. Drive: 6 plays, 56 yards, 0:38.
Third quarter
SF – Elijah Mitchell 8-yard pass from Trey Lance (Robbie Gould kick), 5:53. 49ers 10–7. Drive: 4 plays, 58 yards, 2:21.
Fourth quarter
SF – Deebo Samuel 45-yard pass from Trey Lance (Robbie Gould kick), 9:56. 49ers 17–7. Drive: 4 plays, 65 yards, 2:08.
SF – Robbie Gould 27-yard field goal, 3:19. 49ers 20–7. Drive: 10 plays, 71 yards, 3:27.
SF – Robbie Gould 36-yard field goal, 1:12. 49ers 23–7. Drive: 4 plays, 9 yards, 1:29.
Top passers
HOU – Davis Mills – 21/32, 163 yards, TD, INT
SF – Trey Lance – 16/23, 249 yards, 2 TD, INT
Top rushers
HOU – Rex Burkhead – 16 rushes, 47 yards
SF – Elijah Mitchell – 21 rushes, 119 yards
Top receivers
HOU – Brandin Cooks – 7 receptions, 66 yards, TD
SF – Brandon Aiyuk – 4 receptions, 94 yards :
In Levi's Season Finale the 49ers got off to a slow start, but then they cruised to their 9th victory in Trey Lance's 2nd NFL start to secure their 2nd winning season in 3 years.

#### Week 18: at Los Angeles Rams

| Quarter | 1 | 2 | 3 | 4 | OT | Total |
| 49ers | 0 | 3 | 14 | 7 | 3 | 27 |
| Rams | 3 | 14 | 0 | 7 | 0 | 24 |
at SoFi Stadium, Inglewood, California
* Date: January 9
* Game time: 1:25 p.m. PST
* Game weather: Sunny, 74 °F (23 °C)
* Game attendance: 74,447
* Referee: Jerome Boger
* TV announcers (Fox): Joe Buck, Troy Aikman, Erin Andrews and Tom Rinaldi
* Recap, Game Book
Game information :
First quarter
LAR – Matt Gay 43-yard field goal, 6:07. Rams 3–0. Drive: 13 plays, 62 yards, 8:53.
Second quarter
LAR – Tyler Higbee 2-yard pass from Matthew Stafford (Matt Gay kick), 10:26. Rams 10–0. Drive: 12 plays, 61 yards, 6:25.
LAR – Tyler Higbee 15-yard pass from Matthew Stafford (Matt Gay kick), 6:44. Rams 17–0. Drive: 3 plays, 19 yards, 1:30.
SF – Robbie Gould 42-yard field goal, 0:00. Rams 17–3. Drive: 6 plays, 61 yards, 0:38.
Third quarter
SF – Deebo Samuel 16-yard run (Robbie Gould kick), 10:32. Rams 17–10. Drive: 7 plays, 75 yards, 4:28.
SF – Jauan Jennings 24-yard pass from Deebo Samuel (Robbie Gould kick), 1:46. Tied 17–17. Drive: 11 plays, 74 yards, 7:02.
Fourth quarter
LAR – Cooper Kupp 4-yard pass from Matthew Stafford (Matt Gay kick), 2:29. Rams 24–17. Drive: 9 plays, 92 yards, 5:13.
SF – Jauan Jennings 14-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:26. Tied 24–24. Drive: 5 plays, 88 yards, 1:01.
Overtime
SF – Robbie Gould 24-yard field goal, 2:45. 49ers 27–24. Drive: 12 plays, 69 yards, 7:15.
Top passers
SF – Jimmy Garoppolo – 23/32, 316 yards, TD, 2 INT
LAR – Matthew Stafford – 21/32, 238 yards, 3 TD, 2 INT
Top rushers
SF – Elijah Mitchell – 21 rushes, 85 yards
LAR – Sony Michel – 21 rushes, 43 yards
Top receivers
SF – Brandon Aiyuk – 6 receptions, 107 yards
LAR – Cooper Kupp – 7 receptions, 118 yards, TD :
In a game that looked like certain doom for the 49ers, the 49ers roared back to tie the game on a pass from Deebo Samuel to Jauan Jennings to tie the game up. In overtime, Robbie Gould put the 49ers ahead and Ambry Thomas officially punched the 49ers ticket to the playoffs when he picked off Matthew Stafford, the 49ers would finish the regular season at 10–7. This would be the Rams 7th consecutive defeat by the 49ers.

### Standings
#### Division

NFC West :
| viewtalkedit | W | L | T | PCT | DIV | CONF | PF | PA | STK |
| $^{(4)}$ Los Angeles Rams | 12 | 5 | 0 | .706 | 3–3 | 8–4 | 460 | 372 | L1 |
| $^{(5)}$ Arizona Cardinals | 11 | 6 | 0 | .647 | 4–2 | 7–5 | 449 | 366 | L1 |
| $^{(6)}$ San Francisco 49ers | 10 | 7 | 0 | .588 | 2–4 | 7–5 | 427 | 365 | W2 |
| Seattle Seahawks | 7 | 10 | 0 | .412 | 3–3 | 4–8 | 395 | 366 | W2 |

#### Conference

NFCvte :
| # | Team | Division | W | L | T | PCT | DIV | CONF | SOS | SOV | STK |
| Division winners ||||||||||||
| 1 | Green Bay Packers | North | 13 | 4 | 0 | .765 | 4–2 | 9–3 | .479 | .480 | L1 |
| 2 | Tampa Bay Buccaneers | South | 13 | 4 | 0 | .765 | 4–2 | 8–4 | .467 | .443 | W3 |
| 3 | Dallas Cowboys | East | 12 | 5 | 0 | .706 | 6–0 | 10–2 | .488 | .431 | W1 |
| 4 | Los Angeles Rams | West | 12 | 5 | 0 | .706 | 3–3 | 8–4 | .483 | .409 | L1 |
| Wild cards ||||||||||||
| 5 | Arizona Cardinals | West | 11 | 6 | 0 | .647 | 4–2 | 7–5 | .490 | .492 | L1 |
| 6 | San Francisco 49ers | West | 10 | 7 | 0 | .588 | 2–4 | 7–5 | .500 | .438 | W2 |
| 7 | Philadelphia Eagles | East | 9 | 8 | 0 | .529 | 3–3 | 7–5 | .469 | .350 | L1 |
| Did not qualify for the postseason ||||||||||||
| 8 | New Orleans Saints | South | 9 | 8 | 0 | .529 | 4–2 | 7–5 | .512 | .516 | W2 |
| 9 | Minnesota Vikings | North | 8 | 9 | 0 | .471 | 4–2 | 6–6 | .507 | .434 | W1 |
| 10 | Washington Football Team | East | 7 | 10 | 0 | .412 | 2–4 | 6–6 | .529 | .420 | W1 |
| 11 | Seattle Seahawks | West | 7 | 10 | 0 | .412 | 3–3 | 4–8 | .519 | .424 | W2 |
| 12 | Atlanta Falcons | South | 7 | 10 | 0 | .412 | 2–4 | 4–8 | .472 | .315 | L2 |
| 13 | Chicago Bears | North | 6 | 11 | 0 | .353 | 2–4 | 4–8 | .524 | .373 | L1 |
| 14 | Carolina Panthers | South | 5 | 12 | 0 | .294 | 2–4 | 3–9 | .509 | .412 | L7 |
| 15 | New York Giants | East | 4 | 13 | 0 | .235 | 1–5 | 3–9 | .536 | .485 | L6 |
| 16 | Detroit Lions | North | 3 | 13 | 1 | .206 | 2–4 | 3–9 | .528 | .627 | W1 |
| Tiebreakers ||||||||||||
| 1 2 Green Bay finished ahead of Tampa Bay based on conference record (9–3 vs. 8–4), claiming the No. 1 seed. 1 2 Dallas claimed the No. 3 seed over LA Rams based on conference record (10–2 vs. 8–4). 1 2 Philadelphia finished ahead of New Orleans based on head-to-head victory, claiming the 7th and final playoff spot. 1 2 3 Washington finished ahead of Atlanta and Seattle based on head-to-head victories. 1 2 Seattle finished ahead of Atlanta based on win percentage in common games (4–2 vs. 3–3 against: San Francisco, New Orleans, Jacksonville, Washington, and Detroit). ↑ When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division. ||||||||||||

## Postseason
### Schedule

| Round | Date | Opponent (seed) | Result | Record | Venue | Recap |
| Wild Card | January 16 | at Dallas Cowboys (3) | W 23–17 | 1–0 | AT&T Stadium | Recap |
| Divisional | January 22 | at Green Bay Packers (1) | W 13–10 | 2–0 | Lambeau Field | Recap |
| NFC Championship | January 30 | at Los Angeles Rams (4) | L 17–20 | 2–1 | SoFi Stadium | Recap |

### Game summaries
#### NFC Wild Card Playoffs: at (3) Dallas Cowboys

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 10 | 6 | 7 | 0 | 23 |
| Cowboys | 0 | 7 | 0 | 10 | 17 |
at AT&T Stadium, Arlington, Texas
* Date: January 16, 2022
* Game time: 3:30 p.m. CST/1:30 p.m. PST
* Game weather: None (retractable roof closed)
* Game attendance: 93,470
* Referee: Alex Kemp
* TV announcers (CBS/Nick): CBS: Jim Nantz, Tony Romo, and Tracy WolfsonNickelodeon: Noah Eagle, Nate Burleson, Gabrielle Nevaeh Green, and Young Dylan
* Recap, Game Book
Game information :
First quarter
SF – Elijah Mitchell 4-yard run (Robbie Gould kick), 10:54. 49ers 7–0. Drive: 7 plays, 75 yards, 4:06.
SF – Robbie Gould 53-yard field goal, 4:53. 49ers 10–0. Drive: 9 plays, 23 yards, 4:34.
Second quarter
SF – Robbie Gould 40-yard field goal, 9:40. 49ers 13–0. Drive: 12 plays, 56 yards, 7:58.
DAL – Amari Cooper 20-yard pass from Dak Prescott (Greg Zuerlein kick), 5:19. 49ers 13–7. Drive: 9 plays, 67 yards, 4:21.
SF – Robbie Gould 52-yard field goal, 3:03. 49ers 16–7. Drive: 5 plays, 41 yards, 2:16.
Third quarter
SF – Deebo Samuel 26-yard run (Robbie Gould kick), 5:50. 49ers 23–7. Drive: 1 play, 26 yards, 0:08.
Fourth quarter
DAL – Greg Zuerlein 51-yard field goal, 11:53. 49ers 23–10. Drive: 11 plays, 37 yards, 4:41.
DAL – Dak Prescott 5-yard run (Greg Zuerlein kick), 8:02. 49ers 23–17. Drive: 5 plays, 28 yards, 1:35.
Top passers
SF – Jimmy Garoppolo – 16/25, 172 yards, INT
DAL – Dak Prescott – 23/43, 254 yards, TD, INT
Top rushers
SF – Elijah Mitchell – 27 rushes, 96 yards
DAL – Ezekiel Elliott – 12 rushes, 31 yards
Top receivers
SF – Brandon Aiyuk – 5 receptions, 66 yards
DAL – Dalton Schultz – 7 receptions, 89 yards :
In the first playoff meeting between these two teams since the 1994 NFC Championship, the 49ers upset the Cowboys 23–17. The 49ers' top-five defense shut down the NFL's highest scoring team (the Cowboys were averaging 31.1 points a game during the regular season) to just 17 points, well below the Cowboys' average. This included five sacks, holding the Cowboys to just 77 yards rushing, and one interception, which led to a 49ers touchdown on the next play. The 49ers dominated most of the game, leading 23–7 entering the fourth quarter, and retaining the lead despite a close comeback from the Cowboys. With the win, the 49ers improved their playoff record against the Cowboys to 3–5 all time and defeated the Cowboys for the first time since 2014.

#### NFC Divisional Playoffs: at (1) Green Bay Packers

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 0 | 0 | 3 | 10 | 13 |
| Packers | 7 | 0 | 0 | 3 | 10 |
at Lambeau Field, Green Bay, Wisconsin
* Date: January 22, 2022
* Game time: 7:15 p.m. CST/5:15 p.m. PST
* Game weather: Cloudy, 14 °F (−10 °C)
* Game attendance: 79,132
* Referee: Ronald Torbert
* TV announcers (Fox): Joe Buck, Troy Aikman, Erin Andrews and Tom Rinaldi
* Recap, Game Book
Game information :
First quarter
GB – A. J. Dillon 6-yard run (Mason Crosby kick), 9:25. Packers 7–0. Drive: 10 plays, 69 yards, 5:35.
Second quarter
No scoring plays
Third quarter
SF – Robbie Gould 29-yard field goal, 8:13. Packers 7–3. Drive: 10 plays, 39 yards, 6:47.
Fourth quarter
GB – Mason Crosby 33-yard field goal, 11:27. Packers 10–3. Drive: 14 plays, 57 yards, 9:01.
SF – Talanoa Hufanga 6-yard blocked punt return (Robbie Gould kick), 4:41. Tied 10–10.
SF – Robbie Gould 45-yard field goal, 0:00. 49ers 13–10. Drive: 9 plays, 44 yards, 3:20.
Top passers
SF – Jimmy Garoppolo – 11/19, 131 yards, INT
GB – Aaron Rodgers – 20/29, 225 yards
Top rushers
SF – Elijah Mitchell – 17 rushes, 53 yards
GB – Aaron Jones – 12 rushes, 41 yards
Top receivers
SF – George Kittle – 4 receptions, 63 yards
GB – Aaron Jones – 9 receptions, 129 yards :
The 49ers' Cinderella run continued as they traveled to Lambeau Field and pulled off the upset in a 13–10 win over the heavily favored Green Bay Packers. The game, which was affected by snowfall, was a defensive battle. The Packers started the game with a six-yard touchdown run by AJ Dillion to take a 7–0 lead. For the rest of the game, the 49ers defense only surrendered three more points, aided by five sacks, a fumble recovery, and only giving up 263 total yards of offense to the Packers. The 49ers special teams was pivotal, as they blocked a Packers field goal right before halftime, returned a blocked punt for a game-tying touchdown late in the game, and finally, converted a game-winning field goal by kicker Robbie Gould as time expired, the last of which advanced them to their second NFC Championship in the last three seasons and the 17th NFC Championship overall as a franchise. With the Tennessee Titans' loss earlier in the day to the Cincinnati Bengals, coincidentally also on a field goal as time expired, this was the first time since 2010 that both #1 seeded teams were eliminated in the same weekend. With the win, the 49ers improved to 4–0 in the playoffs against Packers quarterback Aaron Rodgers. The 49ers recorded five sacks for the second game in a row, which is the first time that has happened in consecutive playoff games since the 1984 season.

#### NFC Championship: at (4) Los Angeles Rams

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 0 | 10 | 7 | 0 | 17 |
| Rams | 0 | 7 | 0 | 13 | 20 |
at SoFi Stadium, Inglewood, California
* Date: January 30
* Game time: 3:40 p.m. PST
* Game weather: Sunny, 62 °F (17 °C)
* Game attendance: 73,202
* Referee: Carl Cheffers
* TV announcers (Fox): Joe Buck, Troy Aikman, Erin Andrews, and Tom Rinaldi
* Recap, Game Book
Game information :
First quarter
No scoring plays.
Second quarter
LAR – Cooper Kupp 16-yard pass from Matthew Stafford (Matt Gay kick), 8:46. Rams 7–0. Drive: 18 plays, 97 yards, 9:33.
SF – Deebo Samuel 44-yard pass from Jimmy Garoppolo (Robbie Gould kick), 6:10. Tied 7–7. Drive: 4 plays, 75 yards, 2:36.
SF – Robbie Gould 38-yard field goal, 0:00. 49ers 10–7. Drive: 8 plays, 36 yards, 1:50.
Third quarter
SF – George Kittle 16-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:59. 49ers 17–7. Drive: 10 plays, 58 yards, 5:54.
Fourth quarter
LAR – Cooper Kupp 11-yard pass from Matthew Stafford (Matt Gay kick), 13:30. 49ers 17–14. Drive: 7 plays, 75 yards, 3:29.
LAR – Matt Gay 40-yard field goal, 6:49. Tied 17–17. Drive: 9 plays, 63 yards, 3:06.
LAR – Matt Gay 30-yard field goal, 1:46. Rams 20–17. Drive: 10 plays, 49 yards, 4:40.
Top passers
SF – Jimmy Garoppolo – 16/30, 232 yards, 2 TD, INT
LAR – Matthew Stafford – 31/45, 337 yards, 2 TD, INT
Top rushers
SF – Deebo Samuel – 7 rushes, 26 yards
LAR – Cam Akers – 13 rushes, 48 yards
Top receivers
SF – Deebo Samuel – 4 receptions, 72 yards, TD
LAR – Cooper Kupp – 11 receptions, 142 yards, 2 TD :
The 49ers flew to Los Angeles following their win over the Packers to play their division rival Los Angeles Rams in the NFC Championship Game. During the regular season, the 49ers won both games against the Rams, and were looking to complete the season sweep with a win.
San Francisco won the coin toss and elected to defer. The two teams traded punts before Rams quarterback Matthew Stafford drove the offense to the 49ers' 3-yard line before throwing a drive-ending interception to Jimmie Ward. However, the 49ers were unable to muster any points off the pick, and were forced to punt. In the second quarter, the Rams struck first with Stafford completing a touchdown pass to wide receiver Cooper Kupp from 16 yards out to give the Rams a 7–0 lead. However, San Francisco struck right back with Jimmy Garoppolo hitting Deebo Samuel for a 44-yard touchdown to tie the game up at 7. On the Rams' next drive, the Rams drove to the 49ers' 38-yard line, but could only pick up 2 yards over the next three downs, and kicker Matt Gay's 54-yard field goal attempt sailed wide of the goalposts. With just under two minutes remaining in the first half, Garoppolo completed four straight passes to set up kicker Robbie Gould's 38-yard field goal at the end of the half to put San Francisco up 10–7.
In the second half, the two teams once again traded punts. On the 49ers' second drive of the half, short runs by Samuel and short passes by Garoppolo drove San Francisco down to the Rams' 16-yard line, where he hooked up with tight end George Kittle for a touchdown to make the score 17–7. On the Rams' ensuing drive, long passes by Stafford led to Kupp's second touchdown of the game from 11 yards out to cut the deficit to 17–14 with thirteen minutes left. On the 49ers' next two drives, they were forced to punt. The Rams capitalized, with Gay scoring two field goals from 40 and 30 yards out respectively to make the score 20–17 in favor of Los Angeles.
With just under two minutes remaining, the 49ers' offense trotted out on the field in an attempt to make a desperate last-minute drive to tie the game. After an incompletion on first down, Garoppolo completed a pass to Jauan Jennings, but was tackled immediately by the Rams' Travin Howard to bring up a 3rd-and-13 on the 49ers' 22-yard line. On the very next play, Garoppolo was washed out of the pocket by the Rams' defensive line. Defensive tackle Aaron Donald got a hand on Garoppolo, and in desperation, Garoppolo lobbed the ball up, where it was tipped by JaMycal Hasty before falling into the hands of Howard for a game and season-ending interception. Three kneeldowns by Stafford ended the game, and sent the Rams to their second Super Bowl in the last 4 years.

## Statistics
### Team

| Category | Total yards | Yards per game | NFL rank (out of 32) |
| Passing offense | 4,221 | 248.3 | 12th |
| Rushing offense | 2,166 | 127.4 | 7th |
| Total offense | 6,387 | 375.7 | 7th |
| Passing defense | 3,510 | 206.5 | 6th |
| Rushing defense | 1,760 | 103.5 | 7th |
| Total defense | 5,270 | 310.0 | 3rd |

### Individual

| Category | Player | Total yards |
| Offense |||
| Passing | Jimmy Garoppolo | 3,810 |
| Rushing | Elijah Mitchell | 963 |
| Receiving | Deebo Samuel | 1,405 |
| Defense |||
| Tackles (Solo) | Fred Warner | 79 |
| Sacks | Nick Bosa | 15.5 |
| Interceptions | Jimmie Ward | 2 |
Statistics correct as of the end of the 2021 NFL season