OpenLLM-France/wikimedia huggingface dataset:
# Sandella's Flatbread Café

Sandella's Flatbread Café is an international fast casual restaurant chain founded in 1994 by Michael J. Stimola. The chain is known for its various proprietary flatbread dishes. It is based in Redding, Connecticut.
As of October 2015, the company had over 130 restaurants in the United States, India, Malta, Saudi Arabia, United Arab Emirates and Australia. Some of the company's locations are franchise operations. Sandella's Flatbread Café fare includes flatbread sandwiches, wraps, panini sandwiches, rice bowls, flatbread pizza, quesadilla's, salads.
# Keller Golf Course

Keller Golf Course is a public golf course in Maplewood, Minnesota, a suburb of St. Paul. It is owned and operated by Ramsey County.
Keller hosted the St. Paul Open, a PGA Tour event, from 1930 to 1968. It has also hosted two major championships, the 1932 and 1954 PGA Championships; and the 1949 Western Open, which was often considered a major at the time. In the 1970s, it was home to the LPGA Tour's Patty Berg Classic.

## History

Keller Golf Course opened in 1929. It was designed by Paul Coates, a Ramsey County civil engineer, who reportedly visited some of America's great golf courses to learn the basics of course architecture. The original clubhouse was designed by architect Cap Wigington.
In October, 2012, The course was closed for major renovations under the direction of architect Richard Mandell, and reopened in July, 2014. The course's original layout was retained but the fairways were converted to bent grass, and all of the greens and bunkers were replaced and brought up to modern standards. Mandell's work was recognized by Golf magazine as the "Best Municipal Renovation" of 2014. Additionally, the clubhouse and pro shop were demolished and replaced with new buildings.

## Keller's Golf Professionals

Len Mattson: 1929-1941
Herb Snow: 1942-1968
John Shortridge: 1969-1978
Tom Purcell: 1979-2013
Mark Foley: 2014 - present

## Major tournaments hosted

| Year | Tournament | Winner |
| 1931 | U.S. Amateur Public Links | Charles Ferarra |
| 1932 | PGA Championship | Olin Dutra |
| 1949 | Western Open | Sam Snead |
| 1954 | PGA Championship | Chick Harbert |
* St. Paul Open: 1930–1968
* Patty Berg Classic: 1973–1980
# Jordan national football team results (2020–present)

This article provides details of international football games played by the Jordan national football team from 2020 to present.

## Results by year

| Year | GP | W | D | L | Win % |
| 2020 | 2 | 1 | 1 | 0 | 050.00 |
| 2021 | 22 | 11 | 3 | 8 | 050.00 |
| 2022 | 10 | 8 | 0 | 2 | 080.00 |
| 2023 | 10 | 2 | 2 | 6 | 020.00 |
| 2024 | 21 | 12 | 5 | 4 | 057.14 |
| 2025 | 1 | 0 | 1 | 0 | 000.00 |
| Total | 66 | 34 | 12 | 20 | 051.52 |

## Head-to-head records

    As of match played 27 January 2025 against Uzbekistan

### Key

Head to head records :
| Opponent | P | W | D | L | GF | GA | W% | D% | L% |
| Australia | 2 | 0 | 0 | 2 | 1 | 3 | 0 | 0 | 100 |
| Azerbaijan | 1 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 100 |
| Bahrain | 3 | 2 | 0 | 1 | 4 | 3 | 66.67 | 0 | 33.33 |
| Belarus | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 100 |
| Egypt | 1 | 0 | 0 | 1 | 1 | 3 | 0 | 0 | 100 |
| Haiti | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 100 |
| India | 1 | 1 | 0 | 0 | 2 | 0 | 100 | 0 | 0 |
| Indonesia | 1 | 1 | 0 | 0 | 1 | 0 | 100 | 0 | 0 |
| Iran | 1 | 0 | 0 | 1 | 1 | 3 | 0 | 0 | 100 |
| Iraq | 4 | 1 | 3 | 0 | 5 | 4 | 25 | 75 | 0 |
| Jamaica | 1 | 1 | 0 | 0 | 2 | 1 | 100 | 0 | 0 |
| Japan | 1 | 0 | 0 | 1 | 1 | 6 | 0 | 0 | 100 |
| Kosovo | 1 | 1 | 0 | 0 | 2 | 0 | 100 | 0 | 0 |
| Kuwait | 4 | 1 | 3 | 0 | 5 | 2 | 25 | 75 | 0 |
| Lebanon | 2 | 1 | 0 | 1 | 3 | 2 | 50 | 0 | 50 |
| Malaysia | 2 | 2 | 0 | 0 | 8 | 0 | 100 | 0 | 0 |
| Morocco | 1 | 0 | 0 | 1 | 0 | 4 | 0 | 0 | 100 |
| Nepal | 2 | 2 | 0 | 0 | 5 | 0 | 100 | 0 | 0 |
| New Zealand | 1 | 1 | 0 | 0 | 3 | 1 | 100 | 0 | 0 |
| North Korea | 2 | 1 | 1 | 0 | 2 | 1 | 50 | 50 | 0 |
| Norway | 1 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 100 |
| Oman | 3 | 2 | 1 | 0 | 5 | 0 | 66.67 | 33.33 | 0 |
| Pakistan | 2 | 2 | 0 | 0 | 10 | 0 | 100 | 0 | 0 |
| Palestine | 2 | 2 | 0 | 0 | 8 | 2 | 100 | 0 | 0 |
| Philippines | 1 | 1 | 0 | 0 | 4 | 0 | 100 | 0 | 0 |
| Qatar | 2 | 1 | 0 | 1 | 3 | 4 | 50 | 0 | 50 |
| Saudi Arabia | 3 | 2 | 0 | 1 | 4 | 3 | 66.67 | 0 | 33.33 |
| Serbia | 1 | 0 | 0 | 1 | 2 | 3 | 0 | 0 | 100 |
| South Korea | 3 | 1 | 1 | 1 | 4 | 4 | 33.33 | 33.33 | 33.33 |
| South Sudan | 2 | 2 | 0 | 0 | 5 | 1 | 100 | 0 | 0 |
| Spain | 1 | 0 | 0 | 1 | 1 | 3 | 0 | 0 | 100 |
| Syria | 2 | 2 | 0 | 0 | 3 | 0 | 100 | 0 | 0 |
| Tajikistan | 5 | 3 | 1 | 1 | 7 | 2 | 60 | 20 | 20 |
| United Arab Emirates | 1 | 0 | 0 | 1 | 1 | 5 | 0 | 0 | 100 |
| Uzbekistan | 3 | 1 | 1 | 1 | 3 | 2 | 33.33 | 33.33 | 33.33 |
| Vietnam | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 100 | 0 |
# Arthrobacter humicola

Arthrobacter humicola is a Gram-positive bacterium species from the genus Arthrobacter which has been isolated from soil in Japan.
# Andrea Turini

Andrea Turini or Thurini (circa 1473 – 1543) was an Italian physician and writer.
Born in Pescia in Tuscany, he became a professor of medicine at the University of Pisa. He became a prominent physician, serving both Popes Clement VII and Paul III. He also was a physician for the French kings Louis XII and Francis I. He published a book on his medical practice (Opera Andreae Thurini) in 1545. Tom Virzi attributed a Portrait of a Man and a Dog, depicting Turini, to Raphael in 1910. Andrea's brother Baldassare had been a datary in the papal court and was a friend of Raphael.
# Henry B. Wimbush

Henry Bowser Wimbush (11 March 1858 – 5 May 1943) was an English landscape painter, book illustrator and postcard artist.
Born in London, England, Wimbush first exhibited at the Royal Academy in 1888 and went on to mount several other exhibitions there over the years. He also exhibited at the Royal Institute of Painters in Water Colours and Royal Society of British Artists in London, and in other cities in England.
Working initially in oils, he made the switch to watercolours, painting throughout England, Scotland, Wales and the Channel Islands. He provided illustrations for several books published by A & C Black. He was the leading artist for the postcard company Raphael Tuck & Sons.
In 1880 Wimbush married Margaret Sillar – they went on to have 11 children. After her death in 1927, he married Emily Dremel and lived in Taunton, Somerset where he died in 1943.
Two of his daughters were also artists – Winifred (1884–1958), and Olive (1901–1985).

## Illustrated books

* Carey, Edith F. The Channel Islands (A & C Black, 1904).
* Snell, F. J. North Devon (A & C Black, 1906).
* Morris, J. E. The Channel Islands (A & C Black, 1911).
* Wimbush, H. B. Channel Islands water-colours (A & C Black, 1919).
# BNS Surma (2013)

BNS Surma is a Padma-class offshore patrol vessel of the Bangladesh Navy. She has been serving the Bangladesh Navy since 2013.

## Career

The ship was ordered on 2 May 2010 and launched on 23 January 2013. She was handed over to the Bangladesh Navy on 6 May 2013. On 29 August 2013, she was commissioned to the Bangladesh Navy. She is currently serving under the command of Commodore Commanding BN Khulna (COMKHUL).

## Design

BNS Surma is 50.4 metres (165 ft) long, 7.5 metres (25 ft) wide and 4.1 metres (13 ft) high. The vessel has a displacement of 350 tonnes. She has a top speed of 23 knots (43 km/h; 26 mph). Her complement is 45 persons and can carry out missions lasting up to seven days at a time.

## Armament

The ship is equipped with a pair of 20 mm anti-aircraft guns and a pair of 37 mm guns. The vessel can also be equipped with naval mines and MANPADS.
# Bernard Lachance

Bernard Lachance (23 June 1974 – 11 May 2021) was a Canadian singer-songwriter.

## Biography

Lachance had a great interest in music during his youth, starting with piano. He began studying at the Conservatoire de musique du Québec à Québec in 1989 before leaving Quebec City for Montreal to work in show business. He notably performed at the Capitole de Québec and the Molson Centre. In 1997, he founded the production labels Phénix Productions and Prospectart alongside Serge Paré. He then released his first album, Seul, with composer Jean-Paul Dréau [fr] and engineer Bernard Torelli. It was released in 1998 and received immediate success. However, his production studios closed soon afterwards and he severed ties with Paré.
In 2000, Lachance founded the record label Productions Ad Libitum, with Sylvain Gagné as his sole investor. He then released his second album, Ad Libitum, which sold over 100,000 copies. In 2005, he nearly signed with Universal Music Group, although the partnership did not come to fruition. He then released another album, titled While I Remember You.
In 2003, Lachance performed a solo concert at the Bell Centre, selling 4000 tickets. In 2007, he performed at Massey Hall in Toronto and at Radio City Music Hall in New York City in 2008. The following year, he signed with the record label Isba.
In 2020, Lachance appeared on Denis Lévesque's [fr] program on Le Canal Nouvelles, he alleged that AIDS is a "fraudulent, criminal and also scripted by the same actors and the same institutions as those involved in the COVID-19 pandemic". Lévesque did not broadcast the interview. Lachance then published a paper on the internet on HIV/AIDS denialism. Afterwards, he was invited to Alexis Cossette-Trudel's [fr] YouTube channel to discuss the parallels between AIDS and the COVID-19 pandemic.
Bernard Lachance died on 11 May 2021, at the age of 46. On January 7, 2022, following a coroner's inquiry, it was demonstrated that Bernard Lachance died of HIV-AIDS related sepsis.

## Discography

* Seul (1998)
* Ad Libitum (2000)
* While I Remember You (2005)
# Schuylkill Expressway Bridge

The Schuylkill Expressway Bridge, built in 1956 by the Pennsylvania Department of Transportation, and reconstructed and painted blue in 2010, carries the Schuylkill Expressway (I-76) over the Schuylkill River between West Philadelphia and the Grays Ferry section of South Philadelphia.
# H. D. Thammaiah

H. D. Thammaiah (born 1968) is an Indian politician from Karnataka. He is an MLA from Chikmagalur Assembly constituency in Chikmagalur district representing Indian National Congress. He won the 2023 Karnataka Legislative Assembly election.

## Early life and education

Thammaiah is from Chikmagalur, Karnataka. He is the son of Degundappa. He did his pre university course at Government Primary College, Chikkamagaluru passing out in 1986. He belongs to Lingayat community.

## Career

Thammaiah won from Chikmagalur Assembly constituency representing Indian National Congress in the 2023 Karnataka Legislative Assembly election. He polled 85,054 votes and defeated his nearest rival, C. T. Ravi of Bharatiya Janata Party, by a margin of 5,926 votes. He joined the Congress party just a few days before the election but managed to garner the support of the Congress cadre.
# Kothapalle mandal

Kothapalle Mandal is one of the 64 mandals in East Godavari District of Andhra Pradesh. As per census 2011, there are 16 villages.

## Demographics

Kothapalle Mandal has total population of 82,788 as per the Census 2011. Out of which 41,466 are males while 41,322 are females and the average Sex Ratio of Kothapalle Mandal is 997. The total literacy rate of Kothapalle Mandal is 59.88%. The male literacy rate is 56.19% and the female literacy rate is 50.99%.

## Towns & Villages
### Villages

* Amaravalli
* Aminabada
* Gorsa
* Komaragiri
* Kondevaram
* Kothapalle
* Kutukudumilli
* Mulapeta
* Nagulapalle
* P. Isukapalle
* Ponnada
* K. Isukapalle
* Ramanakkapeta
* Subbampeta
* Uppada
* Vakatippa
* Yendapalle
# Eduardo Águila

Eduardo Águila Castro (born 17 May 2002) is a Mexican professional footballer who plays as a defender for Atlético San Luis.

## Early life

Águila was born on 17 May 2002. Born in Ocotlán, Mexico, he is a native of Ocotlán, Mexico.

## Club career

Águila started his career with Queseros de San José, where he made eleven league appearances and scored one goal. In 2019, he joined the youth academy of La Piedad.
The same year, he joined the youth academy of Atlético San Luis and was promoted to the club's senior team in 2023. During the 2024–25 season, he helped them reach the semi-finals of the Apertura 2024 Liga MX final phase.
# Rockwall Independent School District

Rockwall Independent School District is a public school district established in 1841 in Rockwall, Texas.
In addition to Rockwall, the district serves the cities of Heath, McLendon-Chisholm, Mobile City, most of Fate, and small portions of Rowlett, Wylie, Garland, and Dallas in Rockwall County. The district also extends into a very small portion of northern Kaufman County, including sections of Heath and Travis Ranch. A very small section extends to Collin County.
In 2009, the school district was rated "academically acceptable" by the Texas Education Agency.

## Schools
### High schools

* Grades 9-12
** Rockwall High School
** Rockwall-Heath High School
** Rockwall High School Freshman Center
** Rockwall-Heath High School Freshman Center

### Middle schools

* Grades 7-8
** Maurine Cain Middle
** J.W. Williams Middle
** Herman E. Utley Middle

### Elementary schools

* Grades PK-6
** Amanda Rochell Elementary
** Amy Parks-Heath Elementary
** Billie Stevenson Elementary (2013)
** Celia Hays Elementary (2007)
** Cullins-Lake Pointe Elementary (1988)
** Dorothy Smith Pullen Elementary (1998)
** Dorris A. Jones Elementary
** Grace Hartman Elementary
** Howard Dobbs Elementary
** Linda Lyon Elementary
** Lupe Garcia Elementary
** Nebbie Williams Elementary
** Ouida Springer Elementary
** Sharon Shannon Elementary (2007)
** Sherry and Paul Hamm Elementary (2020)
** Virginia Reinhardt Elementary (1985)

### New Schools Under Construction

Because Rockwall is one of the fastest-growing communities in the US, Rockwall is planning for constructions of more schools.
* In February 2006, Rockwall Independent School District decided to build two more elementary schools at a cost of $31,366,862.
* In addition, land acquisition in the amount of $4,830,996 for 5 new elementary sites and 1 new middle school site has begun.
Rockwall ISD District Construction
# Gabriel Girón

Gabriel Oscar Girón Villarreal (born 27 February 1988) is a Mexican-Panamanian professional basketball player for Libertadores de Querétaro of the Mexican Liga Nacional de Baloncesto Profesional (LNBP). He was a part of the 2017 Mexican championship winning Fuerza Regia team, and was a member of the Mexico's national basketball team at the 2016 FIBA World Olympic Qualifying Tournament – Turin, Italy.

## Personal life

Girón was born in Mexico to a Panamanian father and Mexican mother. His brother Daniel is also a basketball player, who represents Panama internationally.
# That's Where It's At (song)

"That's Where It's At" is a song written by Sam Cooke and J.W. Alexander. Recorded by Cooke, it was released as a single in September 1964.
The song was recorded in 32 takes on August 20, 1963 at the RCA studio in Los Angeles, and released the following month. The backing band on the single consisted of trumpeter John Anderson, bassist Harper Cosby, trombonist John "Streamline" Ewing, drummer June Gardner, saxophonist Jewell Grant, violinist Darel Terwilliger, and guitarists René Hall and Bobby Womack.
It was not initially much of a commercial success, charting no higher than 93 on the Billboard Hot 100. By Cooke's personal standards it was similarly low, especially when compared to his previous and following singles ("Good Times" and "Shake", respectively), both of which were comfortably in the Top 20. However, the song has also garnered critical acclaim in the decades since. It is ranked 876th in American music critic Dave Marsh's 1989 list, The Heart of Rock and Soul: The 1001 Greatest Singles Ever Made.
"That's Where It's At" has been covered by such artists as Van Morrison, Ray Charles, and Bobby Womack, among others.
| Chart (1964) | Peak position |
| Billboard Hot 100 | 93 |
# Jean-Pierre Tokoto

Jean-Pierre Tokoto (born 26 January 1948) is a retired Cameroonian professional footballer. He competed for the Cameroon national team at the 1982 FIFA World Cup.

## Career
### Club

In March 1980, Tokoto signed with the New England Tea Men of the North American Soccer League. In 1981, the team moved to Florida and renamed itself the Jacksonville Tea Men. In the fall of 1981, Tokoto moved to the Philadelphia Fever of the Major Indoor Soccer League.
In 2006, he was selected by CAF as one of the best 200 African football players of the last 50 years.

### Coaching

Jean-Pierre Tokoto was director of coaching at Schwaben AC, a youth soccer team based in Buffalo Grove, Illinois. After many successful years at the club, in 2009 he left the team to create a new club, FC TOKOTO, a college preparatory soccer academy. He now coaches a U-17 and U-16 team for Lions '82 SC a team based in the Rockford Illinois area.

## Personal life

Tokoto's grandson, also named Jean-Pierre, is a basketball player who was drafted in 2015 by the Philadelphia 76ers of the National Basketball Association (NBA). Tokoto has a second grandson, Seth Trimble, who plays college basketball for the North Carolina Tar Heels.

## Honours

Oryx
* Cameroonian Championship: 1963, 1964, 1965, 1967
* Cameroon Cup: 1963, 1968
* African Cup of Champions Clubs: 1965
Marseille
* French Championship: 1972
# Extreme

Extreme may refer to:

## Science and mathematics
### Mathematics

* Extreme point, a point in a convex set which does not lie in any open line segment joining two points in the set
* Maxima and minima, extremes on a mathematical function

### Science

* Extremophile, an organism which thrives in or requires some "extreme" environment
* Extremes on Earth
* List of extrasolar planet extremes

## Politics

* Extremism, political ideologies or actions deemed outside the acceptable range
* The Extreme (Italy) or Historical Far Left, a left-wing parliamentary group in Italy 1867–1904

## Business

* Extreme Networks, a California-based networking hardware company
* Extreme Records, an Australia-based record label
* Extreme Associates, a California-based adult film studio

## Computer science

* Xtreme Mod, a peer-to-peer file sharing client for Windows

## Sports and entertainment
### Sport

* Extreme sport
* Extreme Sports Channel A global sports and lifestyle brand dedicated to extreme sports and youth culture
* Los Angeles Xtreme, a defunct XFL franchise
* Buffalo eXtreme, an ABA franchise

### Music

* Extreme metal, an umbrella term for a group of related heavy metal subgenres
* Extreme (band), an American band
** Extreme (Extreme album), 1989
* Extreme (Molly Nilsson album), 2022
* Xtreme (group), a bachata duo
** Xtreme (album), an album by Xtreme
* Extremes (album), an album by Collin Raye
* X-Treme, a stage name of Italian singer and producer Agostino Carollo

### Other entertainment

* Extreme Sports Channel, a global TV channel dedicated to extreme sports and youth culture
* RTL CBS Extreme, a Southeast Asian TV channel simply known as "Extreme" prior to the rebranding as Blue Ant Extreme
* Extreme (1995 TV series), a 1995 American action series that aired on ABC
* Extreme (2009 TV series), a 2009 American television series that aired on the Travel Channel
* "Extreme" (CSI: Miami), a season two episode of CSI: Miami
* "Extreme" (Doctors), a 2004 television epsiode
* Xtreme (film), 2021 Spanish action film by Daniel Benmayor

## Literature

* The Extreme (novel), a 1998 Animorphs novel by K. A. Applegate
* Extremes (novel), by Kristine Kathryn Rusch
* Extreme Studios, a forerunner of the American comic book studio Image Comics
* Adam X the X-Treme, a character in the Marvel Comics universe
* Extreme, an autobiography by Sharon Osbourne

## Other uses

* Chevrolet Extreme, a name for the Chevrolet S-10 pickup truck
* Extrême, a pre-filled ice-cream cone brand by Nestlé
# Rocky Island (Egypt)

Rocky Island (Arabic: جزيرة روكي) is a small off-shore island of the Red Sea, lying 60–70 kilometres (37–43 mi) from the coast, out in the Red Sea Governorate of Egypt. This tiny uninhabited island gets some shelter from Zabargad Island (6 km [3.7 mi] to the northwest), but also gets fed from north–south currents, which attract lots of pelagic species that feed on or visit the resident marine life.
Rocky Island is well known by scuba divers as one that offers among the best diving sites in the Red Sea.
# Joan Stafford-King-Harman

Cecily Joan Stafford-King-Harman (7 March 1918 – 12 July 2018), also Mrs Dennehy, later Lady Dunn, was an English socialite and one of the first women to work for MI6.

## Biography

The daughter of Sir Cecil Stafford-King-Harman, 2nd Baronet, of Rockingham in County Roscommon, Ireland, and his wife, the former Sarah Beatrice Acland, she "came out" into London society as a debutante in 1935. Her only brother, Thomas Stafford King-Harman, was killed in Normandy in 1944.
During the 1930s, she visited Germany and was impressed with Adolf Hitler. By the time of her death, she was one of the last living people to have met Hitler in person. Having volunteered for Air Raid Precautions (ARP) service at the start of the Second World War in 1939, she was recruited to MI6 by Admiral John Godfrey, mainly for her knowledge of the German language, and worked as a confidential secretary alongside Kim Philby. The department was moved to Bletchley Park, where she also met future author Ian Fleming.
In 1943, she married Captain George Dennehy of the Irish Guards, who later became a solicitor; he died in 1990. From her first marriage, she had four daughters; Rosemary, Sarah, Mary and Caroline. By the time of her death she had 16 grandchildren and 32 great-grandchildren.
Her second husband, whom she married in 1997, was the judge Sir Robin Horace Walford Dunn, whom she had known since childhood; he had three children from his first marriage. Sir Robin died in 2014.
Lady Dunn spent her last years as a resident at Maesbrook care home, Meole Brace, Shrewsbury, where she died in 2018 aged 100 years. A Roman Catholic, she was buried at Odiham Cemetery, Hampshire, on 25 July 2018 following a requiem mass at Shrewsbury Cathedral.
# Combined Saposin Deficiency

Combined Saposin Defiency is a very rare metabolic and genetic disorder that is caused by the mutation in a gene PSAP. This disease belongs to Lysosomal Storage Diseases(LSDs). Because of complete saposin deficiency, it can cause clinical features of 4 diseases(Gaucher’s Disease, Metachromatic Leukodystrophy, Farber’s Disease, Krabbe’s Disease) to be apparent.

## Cause

PSAPD is caused by mutations in a PSAP gene, which is located on the long arm of chromosome 10 (10q22.1).
PSAPD is inherited in a Autosomal Recessive fashion.

## Symptoms

Symptoms usually start in infancy or in neonatal age. The signs of this disease are respiratory failure, hepatosplenomegaly, poor feeding, myoclonus, hyperkinetic movements, clonic seizures, leukodystrophy, hypotonia, abnormality of eye movement and a neuronal loss.
Optic atrophy was only reported in 1 patient

## Pathophysiology

It’s known that Prosaposin is a precursor of a Saposin A,B,C,D. Saposin A is needed to activate galactocerbroside hydrolysis, Saposin B for sulphatide hydrolysis activation, Saposin C for glucocerebroside hydrolysis, Saposin D might activate hydrolysis of ceramide.
According to one study, Prosaposin might be involved in neuron and glial protection by extracellular secretion and activation of some G protein-coupled receptors.
In conclusion, PSAPD might not only cause accumulation of some sphingolipids, but also it can cause neuronal survival crisis (by mechanism mentioned above).

## Prevalence

Prevalence is unknown but 10 cases of this diseases had been reported.

## Diagnosis

The study of sphingolipids in urine sediment (It shows combined massive elevation of globotriaosylceramide (Gb3), sulphatide and some other sphingolipids) might be useful for a correct orientation towards diagnosis, also bone marrow/liver’s biopsies usually show Gaucher-like macrophages. For the final diagnosis PSAP gene would be tested for mutations.

## Prognosis

Unfortunately, prognosis is poor for this disease.

## History

It was first reported by Harzer et al. in 1989