# Whose Line Is It Anyway? (American TV series) season 21

The twenty-first season of the American television series Whose Line Is It Anyway? premiered on The CW on September 6, 2024.

## Production

On May 16, 2024, the series was renewed for a twenty-first season which premiered on September 6, 2024.

## Cast
### Main

* Aisha Tyler
* Ryan Stiles
* Colin Mochrie
* Wayne Brady (absent from episode 8)

### Recurring

* Greg Proops (four episodes)
* Jonathan Mangum (four episodes)
* Brad Sherwood (three episodes)
* Gary Anthony Williams (three episodes)
* Jeff Davis (two episodes)
* Heather Anne Campbell (one episode)

## Episodes

"Winner(s)" of each episode as chosen by host Aisha Tyler are highlighted in italics. The winner(s) perform a sketch during the credit roll, just like in the original British series.
| No. overall | No. in season | Performers | Special guest(s) | Original release date | Prod. code | U.S. viewers (millions) |
| 416 | 1 | Wayne Brady, Greg Proops, Colin Mochrie, Ryan Stiles | Jordin Sparks | September 6, 2024 (2024-09-06) | 1304 | 0.43 |
| Games performed: Hollywood Director, Dubbing (w/Jordin Sparks), Scenes from a Hat, Greatest Hits |||||||
| 417 | 2 | Wayne Brady, Jonathan Mangum, Colin Mochrie, Ryan Stiles | Tiffany Haddish | September 6, 2024 (2024-09-06) | 1303 | 0.39 |
| Games performed: Sound Effects (w/audience members), Scenes from a Hat, Three-Headed Broadway Star (w/Tiffany Haddish), Whose Line, Greatest Hits |||||||
| 418 | 3 | Wayne Brady, Gary Anthony Williams, Colin Mochrie, Ryan Stiles | Alyson Hannigan | September 13, 2024 (2024-09-13) | 1313 | 0.43 |
| Games performed: Dating App (Let's Make A Date), Mixed Messages, Song Styles (w/Alyson Hannigan), Whose Line, Themed Restaurant (w/Alyson Hannigan) |||||||
| 419 | 4 | Wayne Brady, Gary Anthony Williams, Colin Mochrie, Ryan Stiles | Mark Ballas | September 13, 2024 (2024-09-13) | 1301 | 0.39 |
| Games performed: Deleted Scenes, Duet (w/Mark Ballas & an audience member), 90 Second Alphabet, Scenes from a Hat, Greatest Hits |||||||
| 420 | 5 | Wayne Brady, Jonathan Mangum, Colin Mochrie, Ryan Stiles | Chris Jackson | September 27, 2024 (2024-09-27) | 1305 | 0.46 |
| Games performed: Scenes from a Hat, Duet (w/Chris Jackson & an audience member), Whose Line, Doo-Wop, Themed Restaurant (w/Chris Jackson), Greatest Hits |||||||
| 421 | 6 | Wayne Brady, Greg Proops, Colin Mochrie, Ryan Stiles | none | September 27, 2024 (2024-09-27) | 1307 | 0.51 |
| Games performed: Superheroes, Sound Effects (w/audience members), Doo-Wop, Scenes from a Hat, Greatest Hits |||||||
| 422 | 7 | Wayne Brady, Jonathan Mangum, Colin Mochrie, Ryan Stiles | Kaila Mullady | October 4, 2024 (2024-10-04) | 1315 | 0.45 |
| Games performed: Forward Rewind, Deleted Scenes, Scene with Sound (w/Kaila Mullady), Scenes from a Hat, Greatest Hits |||||||
| 423 | 8 | Brad Sherwood, Jeff Davis, Colin Mochrie, Ryan Stiles | Misty May-Treanor | October 4, 2024 (2024-10-04) | 1316 | 0.41 |
| Games performed: Hollywood Director, Hoedown, Dubbing (w/Misty May-Treanor), Scenes from a Hat, Living Scenery (w/Misty May-Treanor) |||||||
| 424 | 9 | Wayne Brady, Heather Anne Campbell, Colin Mochrie, Ryan Stiles | none | October 11, 2024 (2024-10-11) | 1311 | 0.53 |
| Games performed: Let’s Make A Date, Sound Effects (w/audience members), Questions, Whose Line, Greatest Hits |||||||
| 425 | 10 | Wayne Brady, Greg Proops, Colin Mochrie, Ryan Stiles | Chris Lee | October 11, 2024 (2024-10-11) | 1306 | 0.54 |
| Games performed: Press Conference, Duet (w/Chris Lee), Party Quirks, Scenes from a Hat, Greatest Hits |||||||
| 426 | 11 | Wayne Brady, Brad Sherwood, Colin Mochrie, Ryan Stiles | none | October 18, 2024 (2024-10-18) | 1310 | 0.39 |
| Games performed: Party Quirks, Hoedown, Sound Effects (w/audience members), Scenes from a Hat, Greatest Hits |||||||
| 427 | 12 | Wayne Brady, Jonathan Mangum, Colin Mochrie, Ryan Stiles | Tiffany Coyne | October 18, 2024 (2024-10-18) | 1302 | 0.42 |
| Games performed: Dating App, Deleted Scenes, Dubbing (w/Tiffany Coyne), Props, Scenes from a Hat |||||||
| 428 | 13 | Wayne Brady, Gary Anthony Williams, Colin Mochrie, Ryan Stiles | Lauren Cohan | October 25, 2024 (2024-10-25) | 1312 | 0.31 |
| Games performed: Hollywood Director, Duet (w/Lauren Cohan), Scenes from a Hat, Greatest Hits |||||||
| 429 | 14 | Wayne Brady, Jeff Davis, Colin Mochrie, Ryan Stiles | none | October 25, 2024 (2024-10-25) | 1314 | 0.35 |
| Games performed: Questions with Hats, Weird Newscasters, Film Dub, Scenes from a Hat, Greatest Hits |||||||
| 430 | 15 | Wayne Brady, Brad Sherwood, Colin Mochrie, Ryan Stiles | Grace Byers | November 1, 2024 (2024-11-01) | 1308 | 0.47 |
| Games performed: Weird Newscasters, Whose Line, Themed Restaurant (w/Grace Byers), Party Quirks, Greatest Hits |||||||
| 431 | 16 | Wayne Brady, Greg Proops, Colin Mochrie, Ryan Stiles | none | November 1, 2024 (2024-11-01) | 1309 | 0.45 |
| Games performed: Weird Newscasters, Sound Effects (w/audience members), Newsflash, Scenes from a Hat, Greatest Hits |||||||