OpenLLM-France/wikimedia huggingface dataset:
# Netupitant

Netupitant is an antiemetic medication. In the United States, the combinations of netupitant/palonosetron and the prodrug fosnetupitant/palonosetron (both brand name Akynzeo) are approved by the Food and Drug Administration for the prevention of acute and delayed chemotherapy-induced nausea and vomiting, including highly emetogenic chemotherapy such as with cisplatin. In the European Union, the combinations are approved by the European Medicines Agency (EMA) for the same indication.

## Adverse effects

Side effects of the combination netupitant/palonosetron are similar to palonosetron alone, so that no common side effects can be attributed to netupitant.

## Interactions

Netupitant blood plasma levels are expected to increase when combined with inhibitors of the liver enzyme CYP3A4 and lowered when combined with inductors of this enzyme.
Being a CYP3A4 inhibitor itself, netupitant could also increase plasma levels of pharmaceuticals that are metabolized by CYP3A4. This effect has been observed with dexamethasone, the anti-cancer drugs docetaxel and etoposide, and to a minor (not clinically significant) extent with levonorgestrel, erythromycin and midazolam. The clinical relevance of the anti-cancer drug interactions has been questioned.

## Pharmacology
### Mechanism of action

Netupitant is a selective NK$_1$ receptor antagonist.
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

### Pharmacokinetics

Bioavailability is estimated to be over 60% for orally taken netupitant. Highest blood plasma concentrations are reached five hours after application. Availability is moderately (10–20%) increased when taken after a fatty meal. Netupitant and its main metabolites (called M1 and M3) are bound to plasma proteins to more than 99%, and M2 protein binding is 97%.
The substance is mainly metabolized by CYP3A4, and to a lesser extent by CYP2D6 and CYP2C9. The main metabolites are desmethyl-netupitant (M1), netupitant N-oxide (M2), and hydroxy-netupitant (M3); all three are pharmacologically active.
Netupitant and its metabolites are mainly excreted via the faeces. Biological half-life is 88 hours, significantly longer than that of the first NK$_1$ receptor antagonist, aprepitant, which has a half-life of 9 to 13 hours.
# Suzhou Museum of Opera and Theatre

The Suzhou Museum of Opera and Theatre or China Kunqu Museum is a theatre museum in Suzhou, China. The museum was established in 1986. It is located in a Ming dynasty theatre of latticed wood and has display halls with old musical instruments, hand-copied books, lyrics and scores, masks and costumes. It also has other paraphernalia including a life size orchestra and photographs of performers. The museum also covers kunqu's 500-year-old history. The museum is often used for performances today and the teahouse stages daily shows.
# FIA Central European Zone Formula 3

The FIA Central European Zone Formula 3 is an open wheel racing series based in Central and Eastern Europe. The series has been running since 1994 under Formula Libre rules as a sub class of the FIA Central European Circuit Racing series, primarily featuring older Formula Three cars and engines. Notable regular circuits include the Formula 1 circuits of Hungaroring and Red Bull Ring.
According to article 23-B-4 of the FIA World Council Statutes (for Karting the CIK/FIA), a Central European Zone has been established. Members of this zone are: Albania, Austria, Bosnia and Herzegovina, Croatia, Czech Republic, Hungary, Italy, Macedonia, Montenegro, Poland, Serbia, Slovenia and Slovakia.

## Champions

| Season | Formula 3 Champion | Team & Car/Engine |
| 1994 | Tomas Karhanek | WTS - TKF Racing - Dallara F393-Opel |
| 1995 | Jaroslaw Wierczuk | GPF Motorsport - Dallara F393-Fiat |
| 1996 | Jaroslav Kostelecky | Chemopetrol Ring Racing Team - Dallara F394-Mugen-Honda |
| 1997 | Petr Krizan | Franz Wöss Racing - Dallara F393-Opel |
| 1998 | Andrè Fibier | Franz Wöss Racing - Dallara F395-Opel |
| 1999 | Andrè Fibier | Franz Wöss Racing - Dallara F397-Opel |
| 2000 | Fulvio Cavicchi | Azeta Sava Olimpija - Dallara F397-Opel |
| 2001 | Jaroslav Kostelecky | Czech National Team - Dallara F399-Opel |
| 2002 | Richard Lietz | Palfinger F3 Racing Team - Dallara F300-Opel |
| 2003 | Diego Romanini | JMS Jenichen Motorsport - Dallara F399-Opel |
| 2004 | Andreas Zuber | Penker Racing - Dallara F303-Opel |
| 2005 | Michael Herck | Junior Racing Team - Dallara F305-Opel |
| 2006-2015 | Not held | Not held |
| 2016 | Paolo Brajnik | 212 Racing - Dallara F308-VW Spiess |
| 2017 | Andrea Cola | Monolite Racing - Dallara F312-Mercedes |
| 2018 | Andrea Cola | Monolite Racing - Dallara F312-Mercedes |
| 2019 | Tom Beckhäuser | Franz Wöss Racing - Dallara F308-Opel Spiess |
| 2020 | Ralph Pütz | Franz Wöss Racing - Dallara F305-Opel Spiess |
| 2021 | Stefan Fürtbauer | Franz Wöss Racing - Dallara F316 |
| 2022 | Benjámin Berta | Team Hoffmann Racing - Dallara F314-Toyota |
| 2023 | Benjámin Berta | Solution Racing SE - Dallara F316 |
| 2024 | Benjámin Berta | Franz Wöss Racing - Dallara 320 |
# Hélène Florent

Hélène Florent is a Canadian film and television actress. Her roles have included the television series Les Invincibles, Toute la vérité, La galère, and the 2000s revival of Lance et compte, as well as the films Yellowknife, Familia, Life with My Father (La Vie avec mon père) and Café de Flore. She garnered a Genie Award nomination for Best Supporting Actress at the 32nd Genie Awards for her performance in Café de Flore. That film also got her nominated for a Satellite Award for Best Supporting Actress in 2012.
At the 24th Quebec Cinema Awards in 2022 she won both Best Actress for Drunken Birds (Les Oiseaux ivres) and Best Supporting Actress for Maria Chapdelaine, becoming the first actress in the history of the awards to win both categories in the same year.
At the 25th Quebec Cinema Awards in 2023, she received a Best Actress nomination for A Respectable Woman (Une femme respectable).

## Selected filmography

* Blind Spot (Lucidité passagère) - 2009
* Sarah Prefers to Run (Sarah préfère la course) - 2013
* Maria Chapdelaine - 2021
* Drunken Birds (Les Oiseaux ivres) - 2021
* A Respectable Woman (Une femme respectable) - 2023
# Columbus and Rome Railway

The Columbus and Rome Railway is a historic, 3 ft (914 mm) narrow gauge railroad that operated in the U.S. state of Georgia.
Chartered in 1871 as the North and South Railroad of Georgia, the Columbus and Rome Railway opened in 1873 with a 20-mile (32 km) line going north out of Columbus, Georgia. The railroad was eventually extended to Hamilton, Georgia, and by 1888 was operating as far as Greenville. At some time during the final construction to Greenville, the railroad was acquired by and consolidated into the Savannah and Western Railroad, a subsidiary of the Central of Georgia Railway.
# Dayton District

The Dayton District is a railroad line owned and operated by the Norfolk Southern Railway in the U.S. state of Ohio. The line runs from Columbus southwest to Cincinnati along former Pennsylvania Railroad and New York Central Railroad lines. Its east end is at or near the Columbus District, Sandusky District, and West Virginia Secondary; its south end is in Ivorydale, where it meets the Indiana and Ohio Railway's Midland Subdivision, and just past that in Winton Place, where it meets CSX Transportation's Cincinnati Terminal Subdivision. Along the way, it junctions the New Castle District at Evendale.

## History

The oldest part of the line is from Columbus west to London, was opened in 1850 by the Columbus and Xenia Railroad. In 1851, the Springfield and Dayton Railroad opened from Springfield southwest to Dayton. The Springfield and Columbus Railroad opened in 1853 from London west to Springfield. The Cincinnati and Springfield Railway opened the final piece, between Dayton and Bond Hill (part of Cincinnati), in 1872. The Columbus and Xenia Railroad became part of the Pennsylvania Railroad system, while the rest became New York Central Railroad lines. The two companies merged to form Penn Central Transportation in 1968 and were taken over by Conrail in 1976. What was then known as the Cincinnati Line was assigned to Norfolk Southern in the 1999 breakup of Conrail.
# Daichi Taniguchi

Daichi Taniguchi (born April 15, 1990) is a Japanese professional basketball player for Shimane Susanoo Magic of the B.League in Japan. He stood six feet, three inches tall as a 12-year-old boy. In 2009 Taniguchi won the "Slam Dunk Scholarship" funded by Takehiko Inoue, and played for the American colleges. He rejected the offers from the Kansai-area clubs and signed with the Akita Happinets in 2015. Due to the B.League's foreign player regulations, he receives significantly more playing time in 2016–17. He has been named the new Akita captain after Toshino's departure in November 2018. He is a Starbucks mug cup collector and a tropical fish addict. Use of the moyai emoji is usually meant to imply strength or determination, and it's also used frequently in Taniguchi's posts. He signed with Hiroshima Dragonflies on June 24, 2019.

## College statistics

| Year | Team | GP | GS | MPG | FG% | 3P% | FT% | RPG | APG | SPG | BPG | PPG |
| 2010–11 | Arizona Western | 32 | | | .450 | .380 | .810 | 2.063 | 0.313 | 0.375 | 0.344 | 6.4 |
| 2011–12 | Arizona Western | 29 | | | .350 | .200 | .570 | 1.828 | 0.448 | 0.103 | 0.310 | 3.8 |
| 2013–14 | SE OK State | 27 | 16 | 24.3 | .372 | .351 | .667 | 2.67 | 1.74 | 0.52 | 0.37 | 5.52 |
| 2014–15 | SE OK State | 9 | 2 | 6.4 | .100 | .111 | .000 | 0.22 | 0.33 | 0 | 0 | 0.33 |

## Career statistics
### Regular season

| Year | Team | GP | GS | MPG | FG% | 3P% | FT% | RPG | APG | SPG | BPG | PPG |
| bj League 2015–16 | Akita | 24 | | 6.4 | 43.4 | 0 | 50 | 1.2 | 0.2 | 0.1 | 0.2 | 2.1 |
| B League 2016-17 | Akita | 58 | 37 | 18.1 | 36.1 | 31.6 | 25 | 2.4 | 0.7 | 0.5 | 0.5 | 5.4 |
| B League 2017-18 | Akita | 60 | 35 | 15.3 | 36.5 | 31.8 | 64 | 2.9 | 1.2 | 1 | 0.2 | 5.8 |
| B League 2018-19 | Akita | 58 | | 8.4 | 35.0 | 34.2 | 50.0 | 1.1 | 0.7 | 0.3 | 0.1 | 3.4 |
| B League 2019-20 | Hiroshima | 45 | | 9.0 | 43.1 | 39.0 | 72.2 | 1.9 | 0.6 | 0.3 | 0.2 | 3.4 |
| B League 2020-21 | Hiroshima | 31 | | 7.1 | .367 | .375 | .923 | 0.8 | 0.3 | 0.3 | 0.1 | 2.2 |

### Playoffs

| Year | Team | GP | GS | MPG | FG% | 3P% | FT% | RPG | APG | SPG | BPG | PPG |
| 2016-17 | Akita | 2 | | 20.00 | .118 | .133 | .500 | 3.5 | 0.5 | 0.0 | 0.5 | 3.5 |
| 2017-18 | Akita | 5 | 4 | 9.39 | .435 | .421 | 1.000 | 1.4 | 0.6 | 0.4 | 0 | 6.0 |

### Early cup games

| Year | Team | GP | GS | MPG | FG% | 3P% | FT% | RPG | APG | SPG | BPG | PPG |
| 2017 | Akita | 2 | 2 | 18:04 | .500 | .571 | .000 | 2.5 | 3.0 | 0.0 | 0.0 | 9.0 |
| 2018 | Akita | 2 | 1 | 7:55 | .143 | .143 | .500 | 0.5 | 1.5 | 0.0 | 0.0 | 2.0 |
| 2019 | Hiroshima | 3 | 0 | 14:03 | .231 | .000 | .500 | 1.7 | 1.3 | 1.3 | 0.3 | 3.0 |

### Preseason games

| Year | Team | GP | GS | MPG | FG% | 3P% | FT% | RPG | APG | SPG | BPG | PPG |
| 2018 | Akita | 2 | 1 | 8.5 | .333 | .200 | .000 | 1.5 | 1.0 | 0.0 | 0.0 | 2.5 |
Source: Changwon1Changwon2

## Personal

He is the son of Kimiya and Sachiko Taniguchi. His brother Hiroki plays for the Shiga Lakestars of the B.League.
# Twin Mound, Kansas

Twin Mound is a ghost town in western Douglas County, Kansas, United States. It was named for two natural mounds that rise gently from the landscape.

## History

Henry Hiatt was born in Dublin, Indiana, in 1816. In 1856, Hiatt, his wife and five children moved to Kansas Territory, settling in Bloomington. Shortly after his arrival, Hiatt and two other men operated a saw mill, but within a year Hiatt decided to move on and transported his family seven miles southwest. The two nearly identical mounds inspired Hiatt, for he settled in the area and founded his own community, Twin Mounds.
Hiatt gave no explanation as to why he left Bloomington, but Hiatt resented the power of organized church in American society, preferring Confucius' version of the Golden Rule and possibly objected to the regulations the Bloomington Town Company was imposing on the residents. Hiatt was, to a large degree, an anarchist. Hiatt died in 1900 and was buried in a homemade coffin in Twin Mound Cemetery, a cemetery he started in 1858 when his first wife died.
Eventually the s was dropped from the town name. The small farming community was growing steadily and Hiatt had big plans for the town. He began talking up the Twin Mounds Harmonic College which would teach science, facts and laws; not sect, doctrine, nature or creed. The college would also be open to all races, creeds and sexes. The reason Hiatt failed in this venture may possibly have been due to Hiatt's lack of experience and going up against stronger opposition, who wanted a university in Lawrence.
The Twin Mound post office, opened in 1858, was discontinued in 1903.
The townsite remains a small farming community. All that remains is the one-room schoolhouse, the cemetery and the two mounds.
# Government of Moldova

The government of Moldova (Romanian: Guvernul Republicii Moldova) is the government of the Republic of Moldova. It is housed in the Government House at the Great National Assembly Square in Chișinău, the capital of Moldova. Currently, the president of Moldova is Maia Sandu, while the prime minister of Moldova is Dorin Recean. The current ruling cabinet of Moldova is the cabinet of Dorin Recean, incumbent since 16 February 2023.
# Two Groups Islands

18°08′S 142°15′W﻿ / ﻿18.133°S 142.250°W﻿ / -18.133; -142.250
The Two Groups Islands (French: Îles Deux Groupes) is a minor subgroup of the Tuamotus in French Polynesia. It is formed by the atolls of Marokau to the north (populated by 100 people) and the uninhabited Ravahere to the south. The two atolls are separated by a 2 km (1 mi) wide sound.

## History

These two neighboring atolls were discovered by Louis Antoine de Bougainville in 1768. It was James Cook, however, who named them "Two Groups" the following year. He described Marokau and Revahere as a "chain of islands linked by reefs".

## Administration

Administratively the Two Groups Islands belong form the territory of the associated commune of Marokau, itself part of the commune of Hikueru, which consists of the two atolls of the Two Groups Islands (Marokau and Ravahere) and the three atolls of the associated commune of Hikueru (Hikueru, Reitoru and Tekokota).
# Vern McGrew

Vern McGrew (December 7, 1929 – January 9, 2012) was an American high jumper. He competed in the high jump event at the 1948 Summer Olympics at the age of eighteen. He used the western roll technique, which was common at the time, and in 1948 achieved a career best clearance of 2.04 meters (6 ft 8¼ in).
Born in Big Spring, Texas, he went on to attend Lamar High School in Houston, graduating in 1946. That year he won the Texan state championship with a state record jump. He gained a place at Rice University and competed for the Rice Owls athletic team under their coach Emmett Brunson. McGrew became the second Rice alumnus to take part in an Olympic event, after Claude Bracey in 1928.
The 1948 Olympics was his only major international appearance but he achieved some success at national level. While studying at Rice University he competed at the NCAA Championship, coming third in 1948 and finishing as runner-up in 1949. He completed this upward trend by winning the NCAA high jump title in 1950 with a jump of over two meters (6 ft 7 in). At the national-level AAU Championship meeting he was third in 1948 (where he gained Olympic selection), but managed only fifth place the year after.
McGrew undertook post-graduate study at the University of Texas and later the University of Texas Law School. He signed up for military service from 1954 to 1956. He did not take part in athletics in his later life and instead used his studies to gain a placement at Humble Oil, at which he spent 30 years of his working life. He retired in the 1980s and lived until the age of 82. He died at Methodist Hospital in Houston.
# Acheilognathus fasciodorsalis

Acheilognathus fasciodorsalis is a species of freshwater ray-finned fish in the genus Acheilognathus, a bitterling. This fish is endemic to Vietnam.
# South West Coast Path Association

The South West Coast Path Association (SWCPA) is a United Kingdom charitable incorporated organisation (before 2015 a registered charity) which exists to promote the interests of users of the South West Coast Path, the longest National Trail in Britain at 630 miles (1014 km).
The Objects of the SWCPA as set out in its constitution are:
   1: To secure the protection, improvement and conservation of the South West Coast Path and public access to it in order to improve the health and wellbeing of the general public.
   2: To educate the general public to a greater knowledge of, respect and care for, the coast and countryside by promoting the South West Coast Path.
The SWCPA was founded in 1973 as the South West Way Association and renamed in 1999 when the path itself was renamed. In September 2015 it changed its status to become a Charitable incorporated organisation. As of 31 December 2016 it had 6,679 personal members, who receive twice-yearly newsletters and an annual guide to the path (available for sale to non-members), and 503 business members.
Over the years the SWCPA has worked with local authorities and the National Trust to improve the alignment and condition of the path. It contributed funds towards the sculptures erected at Minehead and Poole to mark the ends of the path, and a half-way marker.

## Publications

* South West Coast Path Association (2017). Complete Guide. SWCPA. ISBN 978-0-907055-24-2. (new edition published in January every year; free to members)
* South West Coast Path Association (2006). Reverse Guide. SWCPA. (describes route from Poole to Minehead; available from the Association)
* Carter, Philip (2005). The South West Coast Path, an illustrated history. SWCPA.
# Haddam, Iran

Haddam (Persian: هدام), in Iran, may refer to:
* Haddam-e Yek
* Haddam-e Do
# WCAP (Washington, D.C.)

WCAP was a short-lived radio station located in Washington, D.C. during the mid-1920s. It was initially licensed in mid-1923 to the Chesapeake and Potomac Telephone Company (C&P), and its call letters were chosen to reflect the station owner. C&P was controlled by the American Telephone & Telegraph Company (AT&T), and the station was the second of two, following WEAF (now WFAN) in New York City, that would be established by AT&T. WCAP was high-powered "Class B" station, and it shared time on the 640 AM frequency with WRC (now WTEM), owned by the Radio Corporation of America (RCA).
On May 11, 1926, AT&T announced that a subsidiary, the Broadcasting Company of America (BCA), had been formed to take over its radio broadcasting assets, including WCAP. Two months later AT&T signed an agreement to sell its BCA subsidiary to RCA for $1 million. Because there was no need for RCA to continue operation of two Washington stations, WCAP ceased broadcasting on July 31, 1926, with its hours ceded to WRC.
# Cahide Sonku

Cahide Sonku (born Cahide Serap; 27 December 1919 – 18 March 1981) was a Turkish actress, model, writer and the first female film director in Turkey. Sonku was the founder of her own movie production company, Sonku Film, in 1950. She was thrice married and divorced.

## Life

Sonku' first theater and cinema experience was during her secondary school education. She was accepted into Darülbedayi when she was only 16 years old, and in time she took her place among the most popular actors of Istanbul City Theatres. She started acting with "Seven Village Zeynebi" first at the People's Houses Theater, then at the Istanbul Municipality Conservatory, and then at Darülbedayi (1932-City Theaters), discovered by Muhsin Ertuğrul who was an important figure in Sonku's career.
Sonku founded the production company "Sonku Film" in 1950 and however went bankrupt in 1963 due to a fire that burned down the company building. She continued working at the City Theater through Muhsin Ertuğrul's influence, then left and struggled with alcohol addiction in the last years of her life.
Sonku received the Turkish Film Critics Association service award in 1979 and died in 1981 at the Alkazar Cinema in Istanbul, at the age of 61. She was buried in Zincirlikuyu Cemetery. Cahide Sonku Prize is awarded in her memory at the annual Antalya Golden Orange Film Festival.

## Cultural depictions

* In 1989, the series Cahide is based from life of Cahide Sonku. It starring Hale Soygazi as Cahide.
* In 2013, the short film "Kayıkçı" starring Merih Fırat as Cahide.
* In 2014, the short film "100-5=Cahide" starring Farah Zeynep Abdullah as Cahide.
* In 2016, the short film "Cahide" starring İpek Bilgin as Cahide.

## Filmography

| Year | Film | Duty | Duty | Duty | Duty | Notes |
| Year | Film | Actor | Director | Producer | Role | Notes |
| 1933 | Söz Bir Allah Bir | Yes | | | | |
| 1934 | Bataklı Damın Kızı Aysel | Yes | | | Aysel | |
| 1940 | Şehvet Kurbanı | Yes | | | | |
| 1940 | Akasya Palas | Yes | | | | |
| 1942 | Kıskanç | Yes | | | | |
| 1945 | Yayla Kartalı | Yes | | | Nermin | |
| 1946 | Senede Bir Gün | Yes | | | Nazlı | |
| 1947 | Yuvamı Yıkamazsın | Yes | | | | |
| 1949 | Fedakar Ana | Yes | Yes | | | |
| 1951 | Vatan ve Namık Kemal | Yes | Yes | | | Co-directed with Talat Artemel and Sami Ayanoğlu. |
| 1952 | Günahını Ödeyen Adam | Yes | | | | |
| 1953 | Beklenen Şarkı | Yes | Yes | Yes | | |
| 1955 | İlk ve Son | Yes | | | | |
| 1956 | Büyük Sır | Yes | | | | |
| 1962 | Ayşecik Yavru Melek | Yes | | | | |
| 1965 | Yahya Peygamber | Yes | | | | |
| 1965 | Korkusuzlar | Yes | | | | |
| 1965 | Düşman Kardeşler | Yes | | | | |
| 1965 | Beyaz Atlı Adam | Yes | | | | |
| 1965 | Sevgim ve Gururum | Yes | | | | |
| 1966 | Sevda Çiçeğim | Yes | | | | |
| 1966 | Kovboy Ali | Yes | | | | |
| 1966 | El Kızı | Yes | | | | |
| 1966 | Çalıkuşu | Yes | | | | |
| 1966 | At Avrat Silah | Yes | | | | |
| 1966 | Sokak Kızı | Yes | | | | |
| 1967 | Serseriler Kralı | Yes | | | | |
| 1967 | Bizansı Titreten Yiğit | Yes | | | | |
| 1971 | Mıstık | Yes | | | | |
# Herman Schroeder House and Livery

The Herman Schroeder House and Livery is a historic residence in Shakopee, Minnesota, United States. The house and outbuilding were constructed in 1880 for Herman Schroeder (1854–1922), the longtime owner of Shakopee's most successful brickyard and an influential civic leader. Both buildings feature ornate brick detailing, including on an outhouse addition to the livery. The property was listed on the National Register of Historic Places in 2023 for its significance in the theme of art. It was nominated for its association with Schroeder, a German immigrant whose signature red "Shakopee" bricks were used in numerous buildings throughout the region.